locus-tag	class	description
ISN31_00040	COG0640	Transcriptional regulator
ISN31_00065	COG3047	cAMP biosynthetic process
ISN31_00070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN31_00120	COG3588	fructose-bisphosphate aldolase
ISN31_00165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_00200	COG1393	Belongs to the ArsC family
ISN31_00230	COG0175	sulfate reduction
ISN31_00235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN31_00240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN31_00250	COG0529	Catalyzes the synthesis of activated sulfate
ISN31_00250	COG2895	sulfate adenylyltransferase (ATP) activity
ISN31_00255	COG0840	transmembrane signaling receptor activity
ISN31_00285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN31_00300	COG1609	Transcriptional regulator
ISN31_00320	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN31_00335	COG3273	potassium ion transport
ISN31_00335	COG0471	metal ion transport
ISN31_00345	COG2022	thiamine diphosphate biosynthetic process
ISN31_00365	COG0174	glutamine synthetase
ISN31_00370	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN31_00380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN31_00395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_00420	COG3511	phospholipase C
ISN31_00430	COG0189	ligase activity
ISN31_00440	COG0745	RESPONSE REGULATOR receiver
ISN31_00460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN31_00485	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN31_00525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN31_00525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN31_00535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN31_00550	COG1174	glycine betaine transport
ISN31_00555	COG1125	glycine betaine transport
ISN31_00565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_00570	COG0564	pseudouridine synthase activity
ISN31_00595	COG3387	PFAM Glycoside hydrolase 15-related
ISN31_00645	COG0542	response to heat
ISN31_00670	COG0019	diaminopimelate decarboxylase activity
ISN31_00675	COG4264	IucA IucC family
ISN31_00680	COG2814	Major facilitator Superfamily
ISN31_00685	COG4264	IucA IucC family
ISN31_00695	COG4772	TonB-dependent receptor
ISN31_00705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN31_00705	COG4651	solute:proton antiporter activity
ISN31_00795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_00795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_00820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN31_00860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN31_00865	COG1404	Belongs to the peptidase S8 family
ISN31_00900	COG1295	ribonuclease BN
ISN31_00905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN31_00925	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN31_00930	COG5297	Belongs to the glycosyl hydrolase family 6
ISN31_01035	COG3537	Alpha-1,2-mannosidase
ISN31_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_01065	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN31_01070	COG3858	chitin binding
ISN31_01070	COG1388	LysM domain
ISN31_01085	COG0837	glucose binding
ISN31_01095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN31_01105	COG0494	nUDIX hydrolase
ISN31_01110	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN31_01115	COG3956	TIGRFAM MazG family protein
ISN31_01120	COG1742	UPF0060 membrane protein
ISN31_01125	COG0330	HflC and HflK could
ISN31_01185	COG2124	cytochrome p450
ISN31_01190	COG2124	cytochrome p450
ISN31_01195	COG1141	Ferredoxin
ISN31_01200	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_01205	COG2124	cytochrome p450
ISN31_01210	COG0142	geranyltranstransferase activity
ISN31_01215	COG1657	PFAM Prenyltransferase squalene oxidase
ISN31_01225	COG1304	FMN binding
ISN31_01245	COG4206	TonB-dependent receptor
ISN31_01255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN31_01260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN31_01265	COG0463	Glycosyl transferase, family 2
ISN31_01270	COG0517	IMP dehydrogenase activity
ISN31_01275	COG2982	Protein involved in outer membrane biogenesis
ISN31_01280	COG1272	protein, Hemolysin III
ISN31_01285	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN31_01295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN31_01300	COG0626	cystathionine gamma-synthase activity
ISN31_01305	COG0460	homoserine dehydrogenase
ISN31_01305	COG0527	aspartate kinase activity
ISN31_01310	COG2267	carboxylic ester hydrolase activity
ISN31_01320	COG1760	l-serine dehydratase
ISN31_01335	COG3038	cytochrome b561
ISN31_01355	COG2814	Major facilitator Superfamily
ISN31_01360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN31_01370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_01375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_01390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN31_01450	COG0519	Catalyzes the synthesis of GMP from XMP
ISN31_01465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN31_01485	COG0840	transmembrane signaling receptor activity
ISN31_01495	COG1113	amino acid transport
ISN31_01515	COG2239	Acts as a magnesium transporter
ISN31_01520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN31_01525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN31_01535	COG1660	Displays ATPase and GTPase activities
ISN31_01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN31_01560	COG1137	ATPase activity
ISN31_01575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN31_01620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN31_01645	COG0628	permease
ISN31_01655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN31_01660	COG3178	'Phosphotransferase
ISN31_01675	COG1555	photosystem II stabilization
ISN31_01700	COG1477	protein flavinylation
ISN31_01725	COG4774	siderophore transport
ISN31_01730	COG2146	nitrite reductase [NAD(P)H] activity
ISN31_01740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN31_01745	COG0719	Fe-S assembly protein
ISN31_01750	COG0396	ATPase activity
ISN31_01755	COG0719	Fe-S assembly protein
ISN31_01770	COG0693	protein deglycase activity
ISN31_01785	COG0739	heme binding
ISN31_01800	COG1764	response to oxidative stress
ISN31_01810	COG0384	phenazine biosynthesis protein PhzF
ISN31_01815	COG0527	aspartate kinase activity
ISN31_01840	COG0142	geranyltranstransferase activity
ISN31_01845	COG0629	single-stranded DNA binding
ISN31_01850	COG3550	peptidyl-serine autophosphorylation
ISN31_01865	COG3104	oligopeptide transport
ISN31_01870	COG1297	OPT oligopeptide transporter protein
ISN31_01875	COG0823	Involved in the tonB-independent uptake of proteins
ISN31_01875	COG1506	peptidase
ISN31_01895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN31_01900	COG2879	small protein
ISN31_01905	COG1966	Carbon starvation protein
ISN31_01925	COG0588	phosphoglycerate mutase activity
ISN31_01940	COG2211	Major facilitator Superfamily
ISN31_01970	COG2203	Gaf domain
ISN31_01970	COG3706	GGDEF domain
ISN31_01970	COG4251	negative regulation of phosphorylation
ISN31_01970	COG5001	Diguanylate cyclase
ISN31_01975	COG0835	chemotaxis
ISN31_01980	COG0840	transmembrane signaling receptor activity
ISN31_01985	COG0840	transmembrane signaling receptor activity
ISN31_01990	COG0840	transmembrane signaling receptor activity
ISN31_01995	COG2198	Histidine kinase
ISN31_01995	COG0643	Histidine kinase
ISN31_02005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN31_02025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN31_02035	COG2205	protein histidine kinase activity
ISN31_02065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN31_02070	COG0735	belongs to the Fur family
ISN31_02105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN31_02110	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN31_02115	COG2080	2 iron, 2 sulfur cluster binding
ISN31_02220	COG1187	pseudouridine synthase activity
ISN31_02245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN31_02265	COG1132	(ABC) transporter
ISN31_02285	COG0583	DNA-binding transcription factor activity
ISN31_02325	COG1981	membrane
ISN31_02350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_02355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_02365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_02370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_02375	COG0750	zinc metalloprotease
ISN31_02380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN31_02385	COG0575	Belongs to the CDS family
ISN31_02390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN31_02400	COG0528	UMP kinase activity
ISN31_02410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN31_02450	COG0024	Methionine aminopeptidase
ISN31_02465	COG1393	Belongs to the ArsC family
ISN31_02470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN31_02480	COG0367	asparagine synthase
ISN31_02515	COG1566	PFAM secretion protein HlyD family protein
ISN31_02520	COG2814	Major facilitator Superfamily
ISN31_02555	COG0557	exoribonuclease II activity
ISN31_02565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN31_02575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN31_02595	COG0704	Plays a role in the regulation of phosphate uptake
ISN31_02605	COG0581	inorganic phosphate transmembrane transporter activity
ISN31_02615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN31_02620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN31_02640	COG0659	secondary active sulfate transmembrane transporter activity
ISN31_02645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN31_02655	COG1024	Enoyl-CoA hydratase
ISN31_02715	COG0784	Response regulator, receiver
ISN31_02715	COG2205	protein histidine kinase activity
ISN31_02715	COG5002	protein histidine kinase activity
ISN31_02720	COG2733	membrane
ISN31_02740	COG0686	Belongs to the AlaDH PNT family
ISN31_02745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN31_02750	COG1917	Cupin 2, conserved barrel domain protein
ISN31_02750	COG1396	sequence-specific DNA binding
ISN31_02755	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_02775	COG2223	nitrite transmembrane transporter activity
ISN31_02785	COG0243	molybdopterin cofactor binding
ISN31_02805	COG0477	Major facilitator Superfamily
ISN31_02815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_02820	COG0174	glutamine synthetase
ISN31_02825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN31_02830	COG0174	glutamine synthetase
ISN31_02840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN31_02865	COG3842	ATPase activity
ISN31_02870	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN31_02875	COG1177	transmembrane transport
ISN31_02885	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_02900	COG4535	Mg2 and Co2 transporter CorC
ISN31_02915	COG1702	phosphate starvation-inducible protein PhoH
ISN31_02930	COG0741	lytic transglycosylase activity
ISN31_02935	COG0723	plastoquinol--plastocyanin reductase activity
ISN31_02940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN31_02950	COG2857	Cytochrome c1
ISN31_02955	COG0625	glutathione transferase activity
ISN31_02960	COG2969	positive regulation of protein catabolic process
ISN31_03000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN31_03005	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_03010	COG2095	MarC family integral membrane protein
ISN31_03020	COG1611	Belongs to the LOG family
ISN31_03025	COG3275	phosphorelay sensor kinase activity
ISN31_03070	COG0556	nucleotide-excision repair
ISN31_03105	COG2948	multi-organism process
ISN31_03205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN31_03215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN31_03220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN31_03400	COG0305	Participates in initiation and elongation during chromosome replication
ISN31_03415	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN31_03475	COG3728	DNA packaging
ISN31_03475	COG5484	DNA packaging
ISN31_03555	COG1196	nuclear chromosome segregation
ISN31_03640	COG0438	transferase activity, transferring glycosyl groups
ISN31_03645	COG0438	transferase activity, transferring glycosyl groups
ISN31_03655	COG0438	transferase activity, transferring glycosyl groups
ISN31_03675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN31_03685	COG1960	acyl-CoA dehydrogenase activity
ISN31_03720	COG1570	exodeoxyribonuclease VII activity
ISN31_03725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN31_03730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN31_03730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN31_03735	COG0802	atpase or kinase
ISN31_03740	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN31_03745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN31_03765	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_03785	COG2081	HI0933 family
ISN31_03790	COG4681	YaeQ
ISN31_03795	COG0564	pseudouridine synthase activity
ISN31_03805	COG0625	glutathione transferase activity
ISN31_03810	COG0657	acetylesterase activity
ISN31_03815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN31_03840	COG0513	Belongs to the DEAD box helicase family
ISN31_03845	COG0488	(ABC) transporter
ISN31_03860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN31_03870	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_03910	COG1846	Transcriptional regulator
ISN31_03925	COG0386	Belongs to the glutathione peroxidase family
ISN31_04000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN31_04005	COG0084	hydrolase, TatD family'
ISN31_04020	COG1960	acyl-CoA dehydrogenase activity
ISN31_04030	COG0305	Participates in initiation and elongation during chromosome replication
ISN31_04035	COG0415	Belongs to the DNA photolyase family
ISN31_04050	COG0583	DNA-binding transcription factor activity
ISN31_04065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_04105	COG1404	Belongs to the peptidase S8 family
ISN31_04110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN31_04115	COG2867	negative regulation of translational initiation
ISN31_04125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_04130	COG0735	belongs to the Fur family
ISN31_04135	COG0497	DNA recombination
ISN31_04140	COG1420	regulation of RNA biosynthetic process
ISN31_04145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN31_04150	COG0443	Heat shock 70 kDa protein
ISN31_04155	COG0484	heat shock protein binding
ISN31_04160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN31_04165	COG0287	Prephenate dehydrogenase
ISN31_04165	COG1605	Chorismate mutase
ISN31_04175	COG1132	(ABC) transporter
ISN31_04225	COG2850	peptidyl-arginine hydroxylation
ISN31_04265	COG1194	a g-specific adenine glycosylase
ISN31_04270	COG0552	protein localization to endoplasmic reticulum
ISN31_04280	COG3938	Belongs to the proline racemase family
ISN31_04285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_04300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN31_04310	COG0006	proline dipeptidase activity
ISN31_04325	COG0531	amino acid
ISN31_04350	COG4206	TonB-dependent receptor
ISN31_04360	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN31_04370	COG4771	TonB-dependent receptor
ISN31_04395	COG0742	ribosomal rna small subunit methyltransferase
ISN31_04410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN31_04415	COG0405	Gamma-glutamyltransferase
ISN31_04420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN31_04425	COG3291	Pkd domain containing protein
ISN31_04430	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN31_04440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN31_04450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN31_04460	COG1862	Preprotein translocase
ISN31_04465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN31_04490	COG3706	GGDEF domain
ISN31_04490	COG5001	Diguanylate cyclase
ISN31_04490	COG4251	negative regulation of phosphorylation
ISN31_04490	COG2203	Gaf domain
ISN31_04495	COG1509	lysine 2,3-aminomutase activity
ISN31_04505	COG3548	integral membrane protein
ISN31_04510	COG0402	S-adenosylhomocysteine deaminase activity
ISN31_04540	COG4677	pectinesterase activity
ISN31_04555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN31_04585	COG2166	iron-sulfur cluster assembly
ISN31_04600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN31_04605	COG0137	argininosuccinate synthase activity
ISN31_04610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN31_04615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN31_04625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN31_04630	COG0165	Argininosuccinate lyase
ISN31_04650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN31_04680	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN31_04690	COG1070	Carbohydrate kinase
ISN31_04695	COG2115	Belongs to the xylose isomerase family
ISN31_04700	COG0477	Major facilitator Superfamily
ISN31_04705	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN31_04725	COG0617	tRNA 3'-terminal CCA addition
ISN31_04735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN31_04750	COG0166	Belongs to the GPI family
ISN31_04770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN31_04785	COG0671	phosphoesterase, PA-phosphatase related
ISN31_04810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN31_04815	COG0167	dihydroorotate dehydrogenase activity
ISN31_04830	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_04845	COG0527	aspartate kinase activity
ISN31_04845	COG0460	homoserine dehydrogenase
ISN31_04855	COG2951	lytic endotransglycosylase activity
ISN31_04865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN31_04875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN31_04880	COG0124	histidyl-tRNA synthetase
ISN31_04890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN31_04895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN31_04900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN31_04910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN31_04925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN31_04925	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN31_04940	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN31_04945	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN31_04950	COG0235	Class ii aldolase
ISN31_04955	COG0531	amino acid
ISN31_04960	COG0531	amino acid
ISN31_04975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN31_04980	COG0277	FAD linked oxidase domain protein
ISN31_05000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN31_05015	COG1024	Enoyl-CoA hydratase
ISN31_05060	COG1741	Belongs to the pirin family
ISN31_05065	COG0583	DNA-binding transcription factor activity
ISN31_05085	COG0351	phosphomethylpyrimidine kinase
ISN31_05100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN31_05105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN31_05115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN31_05125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN31_05130	COG3734	2-keto-3-deoxy-galactonokinase
ISN31_05145	COG0800	Aldolase
ISN31_05180	COG2205	protein histidine kinase activity
ISN31_05180	COG2198	Histidine kinase
ISN31_05180	COG0784	Response regulator, receiver
ISN31_05185	COG1024	Enoyl-CoA hydratase
ISN31_05190	COG0318	PFAM AMP-dependent synthetase and ligase
ISN31_05245	COG0840	transmembrane signaling receptor activity
ISN31_05255	COG0840	transmembrane signaling receptor activity
ISN31_05265	COG0835	chemotaxis
ISN31_05275	COG0840	transmembrane signaling receptor activity
ISN31_05285	COG0840	transmembrane signaling receptor activity
ISN31_05290	COG0840	transmembrane signaling receptor activity
ISN31_05295	COG0840	transmembrane signaling receptor activity
ISN31_05305	COG0840	transmembrane signaling receptor activity
ISN31_05315	COG0840	transmembrane signaling receptor activity
ISN31_05320	COG0840	transmembrane signaling receptor activity
ISN31_05325	COG0840	transmembrane signaling receptor activity
ISN31_05330	COG0840	transmembrane signaling receptor activity
ISN31_05345	COG0745	RESPONSE REGULATOR receiver
ISN31_05360	COG1192	Involved in chromosome partitioning
ISN31_05370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN31_05375	COG2198	Histidine kinase
ISN31_05375	COG0643	Histidine kinase
ISN31_05375	COG0784	Response regulator, receiver
ISN31_05380	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN31_05425	COG1684	flagellar biosynthetic protein fliR
ISN31_05430	COG1987	bacterial-type flagellum assembly
ISN31_05440	COG3190	flagellar
ISN31_05490	COG1677	Flagellar hook-basal body complex protein FliE
ISN31_05535	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_05540	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_05545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_05565	COG2201	protein-glutamate methylesterase activity
ISN31_05570	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISN31_05575	COG2197	response regulator
ISN31_05595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN31_05600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN31_05605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN31_05610	COG4786	Flagellar basal body rod
ISN31_05610	COG1256	bacterial-type flagellum assembly
ISN31_05610	COG4786	Flagellar basal body rod
ISN31_05610	COG1256	bacterial-type flagellum assembly
ISN31_05625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN31_05640	COG1749	Flagellar hook protein flgE
ISN31_05650	COG1558	bacterial-type flagellum-dependent cell motility
ISN31_05660	COG0784	Response regulator, receiver
ISN31_05660	COG0835	chemotaxis
ISN31_05720	COG2915	High frequency lysogenization protein hflD homolog
ISN31_05725	COG0482	sulfurtransferase activity
ISN31_05745	COG0542	response to heat
ISN31_05765	COG0492	ferredoxin-NADP+ reductase activity
ISN31_05770	COG1674	ftsk spoiiie
ISN31_05790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN31_05795	COG0038	chloride channel
ISN31_05850	COG1595	DNA-templated transcription, initiation
ISN31_05870	COG3038	cytochrome b561
ISN31_05900	COG2244	polysaccharide biosynthetic process
ISN31_05920	COG4106	trans-aconitate 2-methyltransferase activity
ISN31_05940	COG0438	transferase activity, transferring glycosyl groups
ISN31_05945	COG0438	transferase activity, transferring glycosyl groups
ISN31_05965	COG1132	(ABC) transporter
ISN31_06000	COG1022	Amp-dependent synthetase and ligase
ISN31_06035	COG0512	Glutamine amidotransferase of anthranilate synthase
ISN31_06050	COG2801	Transposase and inactivated derivatives
ISN31_06075	COG1530	ribonuclease E activity
ISN31_06090	COG0428	transporter
ISN31_06105	COG0316	Belongs to the HesB IscA family
ISN31_06105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN31_06125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_06145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN31_06150	COG2957	Belongs to the agmatine deiminase family
ISN31_06160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN31_06165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN31_06170	COG0539	negative regulation of cytoplasmic translation
ISN31_06175	COG0776	regulation of translation
ISN31_06185	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN31_06190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN31_06200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN31_06205	COG0183	Belongs to the thiolase family
ISN31_06210	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN31_06210	COG1024	Enoyl-CoA hydratase
ISN31_06225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN31_06235	COG1426	Protein conserved in bacteria
ISN31_06245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN31_06255	COG0746	molybdenum cofactor guanylyltransferase activity
ISN31_06265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN31_06270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN31_06270	COG0475	glutathione-regulated potassium exporter activity
ISN31_06285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN31_06295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN31_06295	COG0519	Catalyzes the synthesis of GMP from XMP
ISN31_06355	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN31_06360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN31_06370	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN31_06385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN31_06390	COG0668	transmembrane transport
ISN31_06400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN31_06415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_06420	COG1183	phosphatidylcholine synthase activity
ISN31_06430	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN31_06460	COG4191	Histidine kinase
ISN31_06460	COG0784	Response regulator, receiver
ISN31_06465	COG2183	response to ionizing radiation
ISN31_06470	COG0784	Response regulator, receiver
ISN31_06470	COG2205	protein histidine kinase activity
ISN31_06535	COG1649	PFAM Uncharacterised BCR, COG1649
ISN31_06545	COG1304	FMN binding
ISN31_06555	COG0346	lactoylglutathione lyase activity
ISN31_06570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN31_06595	COG1024	Enoyl-CoA hydratase
ISN31_06600	COG1024	Enoyl-CoA hydratase
ISN31_06610	COG1024	Enoyl-CoA hydratase
ISN31_06630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN31_06775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISN31_06785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN31_06790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN31_06800	COG0505	Belongs to the CarA family
ISN31_06810	COG2258	MOSC domain
ISN31_06815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN31_06845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN31_06855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN31_06860	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN31_06905	COG0464	growth
ISN31_06935	COG0494	nUDIX hydrolase
ISN31_06945	COG2814	Major facilitator Superfamily
ISN31_06995	COG0629	single-stranded DNA binding
ISN31_07000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN31_07010	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN31_07290	COG0583	DNA-binding transcription factor activity
ISN31_07295	COG0582	viral genome integration into host DNA
ISN31_07305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN31_07320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN31_07330	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN31_07335	COG1132	(ABC) transporter
ISN31_07345	COG0811	peptide transport
ISN31_07370	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN31_07380	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN31_07395	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN31_07400	COG2009	succinate dehydrogenase
ISN31_07415	COG3842	ATPase activity
ISN31_07420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN31_07435	COG0129	dihydroxy-acid dehydratase activity
ISN31_07450	COG0395	ABC-type sugar transport system, permease component
ISN31_07485	COG2350	Protein conserved in bacteria
ISN31_07490	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN31_07495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN31_07500	COG1187	pseudouridine synthase activity
ISN31_07525	COG0436	Aminotransferase
ISN31_07530	COG4133	protoheme IX ABC transporter activity
ISN31_07575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN31_07580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN31_07585	COG4988	ABC transporter
ISN31_07595	COG1294	oxidase, subunit
ISN31_07645	COG2137	regulation of response to DNA damage stimulus
ISN31_07650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN31_07655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN31_07660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN31_07665	COG1546	Belongs to the CinA family
ISN31_07670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN31_07680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN31_07685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN31_07695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN31_07700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN31_07705	COG1534	Rna-binding protein
ISN31_07720	COG1238	metal cluster binding
ISN31_07730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN31_07745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN31_07750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN31_07755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISN31_07770	COG0504	CTP synthase activity
ISN31_07790	COG0306	phosphate transporter
ISN31_07800	COG1253	flavin adenine dinucleotide binding
ISN31_07815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN31_07850	COG0069	glutamate synthase activity
ISN31_07855	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN31_07865	COG1609	Transcriptional regulator
ISN31_07870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN31_07870	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN31_07875	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN31_07880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN31_07880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN31_07910	COG0577	efflux transmembrane transporter activity
ISN31_07910	COG1136	(ABC) transporter
ISN31_07955	COG0583	DNA-binding transcription factor activity
ISN31_07980	COG0077	Prephenate dehydratase
ISN31_07980	COG1605	Chorismate mutase
ISN31_07985	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN31_07990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN31_08030	COG4221	oxidoreductase activity
ISN31_08045	COG1228	amidohydrolase
ISN31_08060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN31_08095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN31_08105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN31_08110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN31_08115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN31_08150	COG0316	Belongs to the HesB IscA family
ISN31_08220	COG0288	reversible hydration of carbon dioxide
ISN31_08235	COG3844	kynureninase activity
ISN31_08245	COG2925	Exonuclease
ISN31_08305	COG2902	Dehydrogenase
ISN31_08315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_08320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_08350	COG1960	acyl-CoA dehydrogenase activity
ISN31_08355	COG2226	methyltransferase
ISN31_08360	COG1410	methionine synthase
ISN31_08360	COG0646	methionine synthase
ISN31_08365	COG0646	methionine synthase
ISN31_08365	COG1410	methionine synthase
ISN31_08375	COG2755	lipolytic protein G-D-S-L family
ISN31_08375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN31_08385	COG2900	Belongs to the SlyX family
ISN31_08400	COG0386	Belongs to the glutathione peroxidase family
ISN31_08410	COG1725	Transcriptional regulator
ISN31_08415	COG1131	(ABC) transporter
ISN31_08480	COG0835	chemotaxis
ISN31_08485	COG0840	transmembrane signaling receptor activity
ISN31_08490	COG0840	transmembrane signaling receptor activity
ISN31_08505	COG3300	MHYT domain
ISN31_08505	COG5001	Diguanylate cyclase
ISN31_08515	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN31_08540	COG0195	Participates in both transcription termination and antitermination
ISN31_08555	COG1007	ATP synthesis coupled electron transport
ISN31_08595	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN31_08600	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN31_08605	COG0649	NAD binding
ISN31_08610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN31_08620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN31_08650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN31_08710	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN31_08720	COG0688	phosphatidylethanolamine metabolic process
ISN31_08725	COG0741	lytic transglycosylase activity
ISN31_08730	COG0433	COG0433 Predicted ATPase
ISN31_08735	COG0494	nUDIX hydrolase
ISN31_08750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN31_08775	COG0717	Belongs to the dCTP deaminase family
ISN31_08780	COG0489	protein tyrosine kinase activity
ISN31_08790	COG4771	TonB-dependent receptor
ISN31_08800	COG4771	TonB-dependent receptor
ISN31_08805	COG0457	Tetratricopeptide repeat
ISN31_08820	COG3590	peptidase
ISN31_08860	COG0697	spore germination
ISN31_08880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_08885	COG2311	Membrane
ISN31_08890	COG1047	Peptidyl-prolyl cis-trans
ISN31_08895	COG0791	NLP P60 protein
ISN31_08900	COG0791	NLP P60 protein
ISN31_08915	COG1607	acyl-coa hydrolase
ISN31_08925	COG1301	dicarboxylic acid transport
ISN31_08930	COG1785	Belongs to the alkaline phosphatase family
ISN31_08940	COG0037	tRNA processing
ISN31_08945	COG1722	exodeoxyribonuclease VII activity
ISN31_08950	COG0142	geranyltranstransferase activity
ISN31_08960	COG1858	cytochrome C peroxidase
ISN31_08985	COG0515	serine threonine protein kinase
ISN31_08985	COG2815	serine threonine protein kinase
ISN31_08990	COG0631	protein serine/threonine phosphatase activity
ISN31_09085	COG0312	modulator of DNA gyrase
ISN31_09095	COG0312	modulator of DNA gyrase
ISN31_09115	COG2968	Membrane
ISN31_09130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN31_09145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN31_09160	COG0495	leucyl-tRNA aminoacylation
ISN31_09170	COG3118	belongs to the thioredoxin family
ISN31_09185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN31_09195	COG2040	homocysteine
ISN31_09200	COG0833	amino acid
ISN31_09210	COG0346	lactoylglutathione lyase activity
ISN31_09230	COG2878	Part of a membrane complex involved in electron transport
ISN31_09245	COG1595	DNA-templated transcription, initiation
ISN31_09270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN31_09290	COG0251	oxidation-reduction process
ISN31_09300	COG0392	lysyltransferase activity
ISN31_09300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN31_09330	COG2814	Major facilitator Superfamily
ISN31_09335	COG1902	pentaerythritol trinitrate reductase activity
ISN31_09340	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN31_09345	COG1047	Peptidyl-prolyl cis-trans
ISN31_09350	COG1077	Cell shape determining protein MreB Mrl
ISN31_09385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN31_09395	COG1451	nucleotide metabolic process
ISN31_09415	COG0784	Response regulator, receiver
ISN31_09415	COG2198	Histidine kinase
ISN31_09415	COG2205	protein histidine kinase activity
ISN31_09425	COG2186	Transcriptional regulator
ISN31_09430	COG3250	beta-galactosidase activity
ISN31_09495	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN31_09495	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN31_09495	COG1703	isobutyryl-CoA mutase activity
ISN31_09525	COG0183	Belongs to the thiolase family
ISN31_09535	COG0443	Heat shock 70 kDa protein
ISN31_09565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN31_09565	COG1793	dna ligase
ISN31_09570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN31_09570	COG1793	dna ligase
ISN31_09575	COG1201	RNA secondary structure unwinding
ISN31_09585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN31_09590	COG1278	Cold shock
ISN31_09595	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN31_09600	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN31_09605	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_09615	COG2954	triphosphatase activity
ISN31_09625	COG0745	RESPONSE REGULATOR receiver
ISN31_09635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN31_09650	COG0681	Belongs to the peptidase S26 family
ISN31_09655	COG0481	GTPase activity
ISN31_09660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN31_09675	COG1024	Enoyl-CoA hydratase
ISN31_09675	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN31_09695	COG2855	membrane
ISN31_09710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN31_09730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN31_09740	COG0534	Mate efflux family protein
ISN31_09745	COG0335	large ribosomal subunit rRNA binding
ISN31_09750	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN31_09755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN31_09760	COG0228	four-way junction DNA binding
ISN31_09770	COG2070	2-Nitropropane dioxygenase
ISN31_09775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN31_09800	COG0475	glutathione-regulated potassium exporter activity
ISN31_09810	COG0625	glutathione transferase activity
ISN31_09815	COG1082	Xylose isomerase domain protein TIM barrel
ISN31_09825	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN31_09830	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN31_09835	COG1129	ABC transporter
ISN31_09840	COG1879	ABC-type sugar transport system periplasmic component
ISN31_09845	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_09865	COG0129	dihydroxy-acid dehydratase activity
ISN31_09895	COG2207	Transcriptional regulator
ISN31_09940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN31_09965	COG4794	Type iii secretion
ISN31_09995	COG0745	RESPONSE REGULATOR receiver
ISN31_10020	COG1595	DNA-templated transcription, initiation
ISN31_10045	COG0156	8-amino-7-oxononanoate synthase activity
ISN31_10055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN31_10060	COG1845	cytochrome c oxidase, subunit III
ISN31_10065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN31_10115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN31_10115	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ISN31_10205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN31_10220	COG0196	riboflavin kinase activity
ISN31_10235	COG0728	peptidoglycan biosynthetic process
ISN31_10245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISN31_10250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN31_10255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN31_10260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN31_10265	COG0824	Thioesterase
ISN31_10275	COG1024	Enoyl-CoA hydratase
ISN31_10280	COG1946	Acyl-CoA thioesterase
ISN31_10295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN31_10360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN31_10405	COG1643	Atp-dependent helicase
ISN31_10410	COG0783	Belongs to the Dps family
ISN31_10415	COG0514	ATP-dependent DNA helicase (RecQ)
ISN31_10435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN31_10440	COG0602	queuosine metabolic process
ISN31_10450	COG2885	chlorophyll binding
ISN31_10465	COG0848	biopolymer transport protein
ISN31_10475	COG0824	Thioesterase
ISN31_10480	COG2255	four-way junction helicase activity
ISN31_10485	COG3158	transport of potassium into the cell
ISN31_10490	COG0632	four-way junction helicase activity
ISN31_10500	COG0217	transcriptional regulatory protein
ISN31_10540	COG3142	Participates in the control of copper homeostasis
ISN31_10545	COG1446	asparaginase
ISN31_10585	COG2201	protein-glutamate methylesterase activity
ISN31_10590	COG0784	Response regulator, receiver
ISN31_10590	COG0643	Histidine kinase
ISN31_10590	COG2198	Histidine kinase
ISN31_10595	COG0840	transmembrane signaling receptor activity
ISN31_10600	COG0835	chemotaxis
ISN31_10615	COG0189	ligase activity
ISN31_10635	COG1199	ATP-dependent helicase activity
ISN31_10645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN31_10650	COG1216	Glycosyl transferase, family 2
ISN31_10675	COG4585	Histidine kinase
ISN31_10685	COG0850	regulation of cytokinetic process
ISN31_10690	COG2894	cell division
ISN31_10695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN31_10705	COG2205	protein histidine kinase activity
ISN31_10710	COG0745	RESPONSE REGULATOR receiver
ISN31_10720	COG2194	sulfuric ester hydrolase activity
ISN31_10835	COG2814	Major facilitator Superfamily
ISN31_10860	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN31_10860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN31_10875	COG0753	catalase activity
ISN31_10900	COG1063	alcohol dehydrogenase
ISN31_10910	COG3459	Glycosyltransferase 36 associated
ISN31_11020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN31_11030	COG0330	HflC and HflK could
ISN31_11035	COG0330	HflC and HflK could
ISN31_11040	COG0604	alcohol dehydrogenase
ISN31_11060	COG0678	peroxiredoxin activity
ISN31_11070	COG4953	penicillin-binding protein 1C
ISN31_11090	COG2373	Large extracellular alpha-helical protein
ISN31_11145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN31_11160	COG0372	Belongs to the citrate synthase family
ISN31_11185	COG2161	toxin-antitoxin pair type II binding
ISN31_11190	COG4115	mRNA cleavage
ISN31_11210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN31_11215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN31_11220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN31_11230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN31_11235	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_11240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN31_11245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_11255	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN31_11280	COG0714	Associated with various cellular activities
ISN31_11300	COG0537	adenosine 5'-monophosphoramidase activity
ISN31_11330	COG0314	molybdopterin synthase activity
ISN31_11335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN31_11340	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN31_11350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN31_11355	COG1234	tRNA 3'-trailer cleavage
ISN31_11365	COG0859	PFAM glycosyl transferase family 9
ISN31_11385	COG0631	protein serine/threonine phosphatase activity
ISN31_11390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN31_11395	COG0328	RNA-DNA hybrid ribonuclease activity
ISN31_11405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN31_11410	COG3942	CHAP domain
ISN31_11410	COG1388	LysM domain
ISN31_11445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN31_11455	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN31_11500	COG0473	3-isopropylmalate dehydrogenase activity
ISN31_11515	COG4783	chaperone-mediated protein folding
ISN31_11530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN31_11535	COG0248	Ppx GppA phosphatase
ISN31_11540	COG0438	transferase activity, transferring glycosyl groups
ISN31_11550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN31_11560	COG3291	Pkd domain containing protein
ISN31_11565	COG2833	Protein of unknown function (DUF455)
ISN31_11585	COG0285	dihydrofolate synthase activity
ISN31_11590	COG0588	phosphoglycerate mutase activity
ISN31_11610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN31_11615	COG4208	sulfate ABC transporter
ISN31_11620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN31_11625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN31_11630	COG0156	8-amino-7-oxononanoate synthase activity
ISN31_11650	COG2885	chlorophyll binding
ISN31_11670	COG0667	Aldo Keto reductase
ISN31_11685	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN31_11685	COG1902	pentaerythritol trinitrate reductase activity
ISN31_11730	COG0625	glutathione transferase activity
ISN31_11745	COG0039	L-malate dehydrogenase activity
ISN31_11755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN31_11760	COG1217	gtp-binding protein TYPA
ISN31_11775	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN31_11785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN31_11790	COG0203	ribosomal protein L17
ISN31_11815	COG0201	protein transport
ISN31_11825	COG1841	ribosomal large subunit assembly
ISN31_11850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISN31_11855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN31_11860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN31_11870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN31_11875	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN31_11900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN31_11905	COG0089	rRNA binding
ISN31_11910	COG0088	Forms part of the polypeptide exit tunnel
ISN31_11920	COG0051	transcription antitermination factor activity, RNA binding
ISN31_11925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN31_11930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN31_11945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN31_11955	COG0222	ribosome binding
ISN31_11970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN31_11975	COG0250	Participates in transcription elongation, termination and antitermination
ISN31_11980	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN31_11990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN31_12010	COG0012	GTP binding
ISN31_12015	COG0193	aminoacyl-tRNA hydrolase activity
ISN31_12025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN31_12035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN31_12050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN31_12055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN31_12095	COG0488	(ABC) transporter
ISN31_12175	COG3634	alkyl hydroperoxide reductase activity
ISN31_12180	COG0583	DNA-binding transcription factor activity
ISN31_12195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN31_12225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN31_12230	COG0697	spore germination
ISN31_12275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN31_12280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN31_12290	COG2096	Adenosyltransferase
ISN31_12305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN31_12310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN31_12315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN31_12320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN31_12325	COG2967	ApaG domain
ISN31_12330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN31_12360	COG1704	LemA family
ISN31_12365	COG0861	Integral membrane protein TerC family
ISN31_12370	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN31_12380	COG0642	Histidine kinase
ISN31_12395	COG4181	ATPase activity
ISN31_12400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN31_12420	COG4771	TonB-dependent receptor
ISN31_12430	COG0667	Aldo Keto reductase
ISN31_12435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN31_12455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN31_12480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN31_12520	COG2226	methyltransferase
ISN31_12545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN31_12555	COG0494	nUDIX hydrolase
ISN31_12570	COG0739	heme binding
ISN31_12580	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN31_12585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN31_12595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN31_12600	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN31_12625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN31_12640	COG3116	cell division
ISN31_12645	COG0275	rRNA processing
ISN31_12650	COG2001	Belongs to the MraZ family
ISN31_12685	COG0792	nuclease activity
ISN31_12695	COG0277	FAD linked oxidase domain protein
ISN31_12700	COG0745	RESPONSE REGULATOR receiver
ISN31_12705	COG2205	protein histidine kinase activity
ISN31_12715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN31_12720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN31_12740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN31_12745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN31_12750	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN31_12765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN31_12765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN31_12775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN31_12795	COG0488	(ABC) transporter
ISN31_12800	COG0242	peptide deformylase activity
ISN31_12815	COG1960	acyl-CoA dehydrogenase activity
ISN31_12825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN31_12835	COG1696	Membrane protein involved in D-alanine export
ISN31_12855	COG1215	transferase activity, transferring glycosyl groups
ISN31_12865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN31_12920	COG2188	Transcriptional regulator
ISN31_12930	COG1450	Type ii and iii secretion system protein
ISN31_12945	COG3166	PFAM Fimbrial assembly family protein
ISN31_12950	COG3156	type II secretion system protein K
ISN31_12955	COG4795	General secretion pathway protein
ISN31_12960	COG2165	general secretion pathway protein
ISN31_12965	COG4970	Tfp pilus assembly protein FimT
ISN31_12970	COG2165	general secretion pathway protein
ISN31_12975	COG1459	type II secretion system
ISN31_12980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN31_12985	COG1404	Belongs to the peptidase S8 family
ISN31_12990	COG5295	Hep Hag repeat protein
ISN31_13000	COG0840	transmembrane signaling receptor activity
ISN31_13005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN31_13005	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN31_13010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN31_13015	COG4974	Belongs to the 'phage' integrase family
ISN31_13040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN31_13045	COG2927	DNA polymerase III (CHI subunit)
ISN31_13085	COG1183	phosphatidylcholine synthase activity
ISN31_13095	COG0442	prolyl-tRNA aminoacylation
ISN31_13110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN31_13115	COG1127	ABC transporter
ISN31_13120	COG3218	ABC-type transport auxiliary lipoprotein component
ISN31_13120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN31_13150	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN31_13155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN31_13160	COG0662	Cupin 2, conserved barrel domain protein
ISN31_13160	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN31_13185	COG2086	electron transfer activity
ISN31_13200	COG0546	phosphoglycolate phosphatase activity
ISN31_13200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN31_13205	COG0277	FAD linked oxidase domain protein
ISN31_13210	COG0300	oxidoreductase activity
ISN31_13215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_13235	COG0493	'glutamate synthase
ISN31_13270	COG1216	Glycosyl transferase, family 2
ISN31_13270	COG0438	transferase activity, transferring glycosyl groups
ISN31_13275	COG0438	transferase activity, transferring glycosyl groups
ISN31_13275	COG1216	Glycosyl transferase, family 2
ISN31_13280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN31_13295	COG0626	cystathionine gamma-synthase activity
ISN31_13325	COG0625	glutathione transferase activity
ISN31_13335	COG0513	Belongs to the DEAD box helicase family
ISN31_13340	COG0720	synthase
ISN31_13350	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN31_13355	COG1956	GAF domain-containing protein
ISN31_13365	COG4206	TonB-dependent receptor
ISN31_13375	COG0546	phosphoglycolate phosphatase activity
ISN31_13400	COG0339	signal peptide processing
ISN31_13405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISN31_13415	COG2217	Heavy metal translocating P-type atpase
ISN31_13430	COG2132	Multicopper oxidase
ISN31_13445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN31_13455	COG1136	(ABC) transporter
ISN31_13460	COG0577	efflux transmembrane transporter activity
ISN31_13460	COG1136	(ABC) transporter
ISN31_13465	COG0577	efflux transmembrane transporter activity
ISN31_13465	COG1136	(ABC) transporter
ISN31_13475	COG4191	Histidine kinase
ISN31_13485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN31_13500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN31_13515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN31_13525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN31_13535	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN31_13550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN31_13555	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN31_13590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN31_13595	COG0697	spore germination
ISN31_13600	COG1666	GTP binding
ISN31_13610	COG1187	pseudouridine synthase activity
ISN31_13635	COG2205	protein histidine kinase activity
ISN31_13635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN31_13660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN31_13725	COG0842	Transport permease protein
ISN31_13730	COG1131	(ABC) transporter
ISN31_13735	COG0025	NhaP-type Na H and K H
ISN31_13745	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN31_13750	COG1573	uracil-dna glycosylase
ISN31_13765	COG3384	dioxygenase
ISN31_13785	COG0667	Aldo Keto reductase
ISN31_13795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_13800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_13820	COG3706	GGDEF domain
ISN31_13830	COG5001	Diguanylate cyclase
ISN31_13860	COG4106	trans-aconitate 2-methyltransferase activity
ISN31_13870	COG2076	Multidrug Resistance protein
ISN31_13880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN31_13910	COG3275	phosphorelay sensor kinase activity
ISN31_13915	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN31_13935	COG0531	amino acid
ISN31_13945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_13945	COG5297	Belongs to the glycosyl hydrolase family 6
ISN31_13960	COG0741	lytic transglycosylase activity
ISN31_13980	COG2207	Transcriptional regulator
ISN31_13990	COG0598	Magnesium transport protein CorA
ISN31_13995	COG1113	amino acid transport
ISN31_14000	COG0697	spore germination
ISN31_14025	COG2267	carboxylic ester hydrolase activity
ISN31_14145	COG0840	transmembrane signaling receptor activity
ISN31_14160	COG2353	YceI-like domain
ISN31_14190	COG0584	glycerophosphoryl diester phosphodiesterase
ISN31_14205	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN31_14225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN31_14230	COG0459	protein refolding
ISN31_14245	COG1324	tolerance protein
ISN31_14250	COG4232	protein-disulfide reductase activity
ISN31_14255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN31_14265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN31_14270	COG0511	ligase activity, forming carbon-carbon bonds
ISN31_14275	COG0439	Biotin carboxylase
ISN31_14290	COG2264	protein methyltransferase activity
ISN31_14310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN31_14315	COG4589	Belongs to the CDS family
ISN31_14335	COG2267	carboxylic ester hydrolase activity
ISN31_14340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN31_14345	COG0138	bifunctional purine biosynthesis protein purh
ISN31_14350	COG0151	Belongs to the GarS family
ISN31_14355	COG1289	transmembrane transporter activity
ISN31_14360	COG2814	Major facilitator Superfamily
ISN31_14400	COG2816	NAD+ diphosphatase activity
ISN31_14440	COG2906	2 iron, 2 sulfur cluster binding
ISN31_14445	COG1051	belongs to the nudix hydrolase family
ISN31_14470	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN31_14485	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN31_14490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN31_14495	COG0730	response to heat
ISN31_14505	COG0134	indole-3-glycerol-phosphate synthase activity
ISN31_14510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN31_14530	COG1597	lipid kinase activity
ISN31_14545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN31_14560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_14565	COG2111	Na H antiporter
ISN31_14565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN31_14570	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN31_14575	COG0651	ATP synthesis coupled electron transport
ISN31_14580	COG1863	multisubunit Na H antiporter MnhE subunit
ISN31_14585	COG2212	antiporter activity
ISN31_14590	COG1320	monovalent cation:proton antiporter activity
ISN31_14595	COG0530	calcium, potassium:sodium antiporter activity
ISN31_14615	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN31_14635	COG3104	oligopeptide transport
ISN31_14655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN31_14670	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN31_14690	COG0513	Belongs to the DEAD box helicase family
ISN31_14720	COG2354	Protein conserved in bacteria
ISN31_14740	COG1196	nuclear chromosome segregation
ISN31_14740	COG3264	Mechanosensitive ion channel
ISN31_14745	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_14745	COG3321	synthase
ISN31_14745	COG0604	alcohol dehydrogenase
ISN31_14765	COG1595	DNA-templated transcription, initiation
ISN31_14780	COG1802	Transcriptional regulator
ISN31_14795	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ISN31_14825	COG1414	Transcriptional regulator
ISN31_14830	COG0738	Major facilitator superfamily
ISN31_14835	COG3254	rhamnose metabolic process
ISN31_14840	COG4948	Mandelate Racemase Muconate Lactonizing
ISN31_14845	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN31_14850	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_14885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN31_14900	COG4807	Protein conserved in bacteria
ISN31_14940	COG1506	peptidase
ISN31_14940	COG0823	Involved in the tonB-independent uptake of proteins
ISN31_15025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN31_15050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN31_15055	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN31_15060	COG0753	catalase activity
ISN31_15085	COG1136	(ABC) transporter
ISN31_15090	COG0577	efflux transmembrane transporter activity
ISN31_15110	COG0697	spore germination
ISN31_15125	COG0180	Tryptophanyl-tRNA synthetase
ISN31_15160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN31_15165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN31_15165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN31_15175	COG3228	Belongs to the MtfA family
ISN31_15205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN31_15230	COG2084	Dehydrogenase
ISN31_15235	COG1902	pentaerythritol trinitrate reductase activity
ISN31_15245	COG2814	Major facilitator Superfamily
ISN31_15250	COG0583	DNA-binding transcription factor activity
ISN31_15265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN31_15270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN31_15280	COG1764	response to oxidative stress
ISN31_15285	COG1846	Transcriptional regulator
ISN31_15290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN31_15300	COG0697	spore germination
ISN31_15305	COG0523	cobalamin synthesis protein
ISN31_15315	COG1742	UPF0060 membrane protein
ISN31_15325	COG3245	cytochrome
ISN31_15335	COG1960	acyl-CoA dehydrogenase activity
ISN31_15340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN31_15360	COG1278	Cold shock
ISN31_15380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN31_15385	COG3387	PFAM Glycoside hydrolase 15-related
ISN31_15390	COG0745	RESPONSE REGULATOR receiver
ISN31_15415	COG3100	YcgL domain-containing protein
ISN31_15420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN31_15430	COG0463	Glycosyl transferase, family 2
ISN31_15465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN31_15480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN31_15505	COG1294	oxidase, subunit
ISN31_15510	COG1271	oxidase subunit
ISN31_15530	COG0408	coproporphyrinogen oxidase activity
ISN31_15540	COG2323	membrane
ISN31_15545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_15545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN31_15560	COG0589	response to stress
ISN31_15585	COG0210	DNA helicase
ISN31_15635	COG0463	Glycosyl transferase, family 2
ISN31_15645	COG1475	DNA binding
ISN31_15650	COG1192	Involved in chromosome partitioning
ISN31_15655	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN31_15665	COG2091	lysine biosynthetic process via aminoadipic acid
ISN31_15690	COG0477	Major facilitator Superfamily
ISN31_15710	COG1971	Probably functions as a manganese efflux pump
ISN31_15715	COG2205	protein histidine kinase activity
ISN31_15725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN31_15730	COG3459	Glycosyltransferase 36 associated
ISN31_15735	COG2211	Major facilitator Superfamily
ISN31_15755	COG2911	Protein conserved in bacteria
ISN31_15760	COG0729	surface antigen
ISN31_15780	COG3132	Protein of unknown function, DUF480
ISN31_15810	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN31_15825	COG1609	Transcriptional regulator
ISN31_15835	COG2937	Belongs to the GPAT DAPAT family
ISN31_15860	COG2211	Major facilitator Superfamily
ISN31_15875	COG3693	PFAM glycoside hydrolase, family 10
ISN31_15880	COG1904	glucuronate isomerase
ISN31_15895	COG3386	PFAM SMP-30 Gluconolaconase
ISN31_15925	COG0246	Mannitol dehydrogenase
ISN31_15930	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN31_15940	COG4948	Mandelate Racemase Muconate Lactonizing
ISN31_15950	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN31_15960	COG2115	Belongs to the xylose isomerase family
ISN31_15965	COG0037	tRNA processing
ISN31_15985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN31_15995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN31_16005	COG0805	protein transport
ISN31_16015	COG0519	Catalyzes the synthesis of GMP from XMP
ISN31_16015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN31_16020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN31_16040	COG0210	DNA helicase
ISN31_16045	COG1435	thymidine kinase activity
ISN31_16055	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN31_16070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN31_16085	COG1119	ATPase activity
ISN31_16095	COG0706	membrane insertase activity
ISN31_16100	COG0594	ribonuclease P activity
ISN31_16115	COG0592	DNA-directed DNA polymerase activity
ISN31_16120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN31_16125	COG0187	DNA topoisomerase II activity
ISN31_16130	COG1266	CAAX protease self-immunity
ISN31_16135	COG0501	Belongs to the peptidase M48B family
ISN31_16165	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISN31_16175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN31_16190	COG1280	lysine exporter protein (LysE YggA)
ISN31_16205	COG4772	TonB-dependent receptor
ISN31_16215	COG3284	Transcriptional regulator
ISN31_16220	COG1012	belongs to the aldehyde dehydrogenase family
ISN31_16255	COG1304	FMN binding
ISN31_16260	COG2186	Transcriptional regulator
ISN31_16280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN31_16365	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN31_16385	COG4771	TonB-dependent receptor
ISN31_16430	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN31_16445	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN31_16450	COG1609	Transcriptional regulator
ISN31_16460	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISN31_16465	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_16480	COG3186	Phenylalanine-4-hydroxylase
ISN31_16485	COG1522	sequence-specific DNA binding
ISN31_16525	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN31_16540	COG0671	phosphoesterase, PA-phosphatase related
ISN31_16555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN31_16590	COG1929	Belongs to the glycerate kinase type-1 family
ISN31_16600	COG0531	amino acid
ISN31_16605	COG4566	intracellular signal transduction
ISN31_16610	COG4191	Histidine kinase
ISN31_16630	COG1322	Protein conserved in bacteria
ISN31_16635	COG0386	Belongs to the glutathione peroxidase family
ISN31_16640	COG2853	Lipoprotein
ISN31_16655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN31_16660	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN31_16665	COG1127	ABC transporter
ISN31_16670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN31_16675	COG1074	ATP-dependent DNA helicase activity
ISN31_16680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN31_16700	COG0537	adenosine 5'-monophosphoramidase activity
ISN31_16725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISN31_16775	COG0477	Major facilitator Superfamily
ISN31_16780	COG0302	gtp cyclohydrolase
ISN31_16805	COG0730	response to heat
ISN31_16825	COG2951	lytic endotransglycosylase activity
ISN31_16885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_16890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_16895	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN31_16900	COG0493	'glutamate synthase
ISN31_16905	COG0067	glutamate synthase
ISN31_16905	COG0070	glutamate synthase
ISN31_16905	COG0069	glutamate synthase activity
ISN31_16950	COG1111	helicase
ISN31_16950	COG1205	dead DEAH box helicase
ISN31_16980	COG2271	Major facilitator Superfamily
ISN31_17030	COG2062	phosphohistidine phosphatase, SixA
ISN31_17040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN31_17045	COG2050	protein possibly involved in aromatic compounds catabolism
ISN31_17055	COG2267	carboxylic ester hydrolase activity
ISN31_17065	COG1881	PFAM PEBP family protein
ISN31_17070	COG1968	undecaprenyl-diphosphatase activity
ISN31_17075	COG0174	glutamine synthetase
ISN31_17080	COG0347	Belongs to the P(II) protein family
ISN31_17085	COG0004	ammonium transporteR
ISN31_17090	COG3852	Histidine kinase
ISN31_17095	COG2204	response regulator
ISN31_17100	COG2032	superoxide dismutase activity
ISN31_17105	COG2032	superoxide dismutase activity
ISN31_17115	COG0183	Belongs to the thiolase family
ISN31_17155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN31_17160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN31_17170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN31_17180	COG0612	Peptidase, M16
ISN31_17190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN31_17195	COG3177	Filamentation induced by cAMP protein fic
ISN31_17210	COG0596	Alpha beta hydrolase
ISN31_17220	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN31_17225	COG0318	PFAM AMP-dependent synthetase and ligase
ISN31_17240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN31_17250	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN31_17265	COG4232	protein-disulfide reductase activity
ISN31_17270	COG0564	pseudouridine synthase activity
ISN31_17290	COG0339	signal peptide processing
ISN31_17310	COG0583	DNA-binding transcription factor activity
ISN31_17315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN31_17320	COG2224	Isocitrate lyase
ISN31_17355	COG0659	secondary active sulfate transmembrane transporter activity
ISN31_17385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN31_17390	COG2130	NADP-dependent
ISN31_17405	COG1187	pseudouridine synthase activity
ISN31_17415	COG1643	Atp-dependent helicase
ISN31_17420	COG0084	hydrolase, TatD family'
ISN31_17510	COG0842	Transport permease protein
ISN31_17515	COG1131	(ABC) transporter
ISN31_17520	COG0633	Ferredoxin
ISN31_17520	COG0543	2 iron, 2 sulfur cluster binding
ISN31_17530	COG1476	TRANSCRIPTIONal
ISN31_17540	COG4555	ABC transporter
ISN31_17560	COG0625	glutathione transferase activity
ISN31_17635	COG1199	ATP-dependent helicase activity
ISN31_17680	COG0628	permease
ISN31_17690	COG2963	transposase activity
ISN31_17720	COG2133	pyrroloquinoline quinone binding
ISN31_17750	COG0754	glutathionylspermidine amidase activity
ISN31_17760	COG0714	Associated with various cellular activities
ISN31_17795	COG1522	sequence-specific DNA binding
ISN31_17810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN31_17825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_17830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_17855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN31_17890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN31_17900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN31_17920	COG2224	Isocitrate lyase
ISN31_17950	COG0076	glutamate decarboxylase activity
ISN31_17980	COG2267	carboxylic ester hydrolase activity
ISN31_17995	COG0606	chelatase, subunit chli
ISN31_18000	COG2960	long-chain fatty acid transporting porin activity
ISN31_18020	COG1166	arginine decarboxylase activity
ISN31_18025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN31_18030	COG1819	glycosyl
ISN31_18035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN31_18035	COG2755	lipolytic protein G-D-S-L family
ISN31_18040	COG0583	DNA-binding transcription factor activity
ISN31_18060	COG4221	oxidoreductase activity
ISN31_18080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN31_18100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN31_18110	COG2814	Major facilitator Superfamily
ISN31_18120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN31_18125	COG0739	heme binding
ISN31_18130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN31_18160	COG1064	alcohol dehydrogenase
ISN31_18165	COG2234	aminopeptidase activity
ISN31_18175	COG4942	peptidase
ISN31_18180	COG0793	Belongs to the peptidase S41A family
ISN31_18215	COG0531	amino acid
ISN31_18220	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ISN31_18220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ISN31_18225	COG1486	melibiose metabolic process
ISN31_18245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN31_18245	COG1565	acr, cog1565
ISN31_18250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN31_18255	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN31_18285	COG0109	protoheme IX farnesyltransferase activity
ISN31_18300	COG0358	DNA primase activity
ISN31_18305	COG1295	ribonuclease BN
ISN31_18325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN31_18345	COG2308	Evidence 4 Homologs of previously reported genes of
ISN31_18360	COG2133	pyrroloquinoline quinone binding
ISN31_18380	COG0531	amino acid
ISN31_18390	COG4948	Mandelate Racemase Muconate Lactonizing
ISN31_18400	COG4771	TonB-dependent receptor
ISN31_18430	COG3409	Peptidoglycan-binding domain 1 protein
ISN31_18430	COG3501	Rhs element vgr protein
ISN31_18465	COG5383	Protein conserved in bacteria
ISN31_18480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN31_18485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN31_18500	COG1652	LysM domain
ISN31_18510	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN31_18515	COG1518	maintenance of DNA repeat elements
ISN31_18555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_18565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN31_18575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN31_18580	COG3118	belongs to the thioredoxin family
ISN31_18590	COG2884	Cell division ATP-binding protein ftsE
ISN31_18595	COG2177	Part of the ABC transporter FtsEX involved in
ISN31_18600	COG2201	protein-glutamate methylesterase activity
ISN31_18605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN31_18610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN31_18615	COG2860	membrane
ISN31_18620	COG1252	NADH dehydrogenase
ISN31_18630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN31_18640	COG0534	Mate efflux family protein
ISN31_18645	COG0616	signal peptide processing
ISN31_18655	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_18670	COG0009	L-threonylcarbamoyladenylate synthase
ISN31_18675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN31_18675	COG1754	DNA topoisomerase type I activity
ISN31_18680	COG1714	RDD family
ISN31_18695	COG0758	DNA mediated transformation
ISN31_18700	COG1652	LysM domain
ISN31_18705	COG0242	peptide deformylase activity
ISN31_18710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN31_18715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN31_18715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN31_18720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN31_18730	COG3307	-O-antigen
ISN31_18755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN31_18770	COG1490	D-aminoacyl-tRNA deacylase activity
ISN31_18775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN31_18805	COG1609	Transcriptional regulator
ISN31_18815	COG0366	Alpha amylase catalytic
ISN31_18820	COG0366	Alpha amylase catalytic
ISN31_18890	COG1309	transcriptional regulator
ISN31_18930	COG0840	transmembrane signaling receptor activity
ISN31_18950	COG3546	catalase activity
ISN31_18955	COG3685	Protein conserved in bacteria
ISN31_18960	COG3685	Protein conserved in bacteria
ISN31_18965	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_18975	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN31_18990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN31_19005	COG0028	Belongs to the TPP enzyme family
ISN31_19010	COG4191	Histidine kinase
ISN31_19015	COG2204	response regulator
ISN31_19040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN31_19045	COG0732	type I restriction modification DNA specificity domain
ISN31_19055	COG3645	SOS response
ISN31_19090	COG2223	nitrite transmembrane transporter activity
ISN31_19095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN31_19100	COG2146	nitrite reductase [NAD(P)H] activity
ISN31_19105	COG0243	molybdopterin cofactor binding
ISN31_19135	COG1640	4-alpha-glucanotransferase
ISN31_19140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN31_19160	COG0745	RESPONSE REGULATOR receiver
ISN31_19185	COG0181	hydroxymethylbilane synthase activity
ISN31_19210	COG1733	regulation of RNA biosynthetic process
ISN31_19225	COG1505	serine-type exopeptidase activity
ISN31_19230	COG0436	Aminotransferase
ISN31_19240	COG2832	Protein of unknown function (DUF454)
ISN31_19250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN31_19295	COG2226	methyltransferase
ISN31_19305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN31_19310	COG0308	aminopeptidase N
ISN31_19315	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN31_19315	COG0596	Alpha beta hydrolase
ISN31_19340	COG2010	Cytochrome c
ISN31_19350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN31_19360	COG3284	Transcriptional regulator
ISN31_19365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN31_19370	COG1077	Cell shape determining protein MreB Mrl
ISN31_19375	COG1792	Involved in formation and maintenance of cell shape
ISN31_19385	COG0768	penicillin binding
ISN31_19390	COG0772	Belongs to the SEDS family
ISN31_19405	COG2951	lytic endotransglycosylase activity
ISN31_19415	COG1686	Belongs to the peptidase S11 family
ISN31_19500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN31_19530	COG1056	cytidyltransferase-related domain
ISN31_19530	COG1051	belongs to the nudix hydrolase family
ISN31_19550	COG1090	epimerase
ISN31_19560	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN31_19565	COG0673	inositol 2-dehydrogenase activity
ISN31_19570	COG2823	Periplasmic or secreted lipoprotein
ISN31_19580	COG2205	protein histidine kinase activity
ISN31_19580	COG2202	Pas domain
ISN31_19585	COG0784	Response regulator, receiver
ISN31_19590	COG4191	Histidine kinase
ISN31_19600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN31_19605	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_19620	COG4305	rare lipoprotein A
ISN31_19630	COG3250	beta-galactosidase activity
ISN31_19645	COG2188	Transcriptional regulator
ISN31_19650	COG0738	Major facilitator superfamily
ISN31_19655	COG1609	Transcriptional regulator
ISN31_19660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN31_19665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN31_19675	COG0617	tRNA 3'-terminal CCA addition
ISN31_19695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN31_19745	COG2205	protein histidine kinase activity
ISN31_19760	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN31_19765	COG3791	Glutathione-dependent formaldehyde-activating
ISN31_19810	COG0804	urea catabolic process
ISN31_19815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN31_19835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN31_19865	COG1162	GTPase activity
ISN31_19890	COG2211	Major facilitator Superfamily
ISN31_19900	COG1028	Short-chain dehydrogenase reductase Sdr
ISN31_19905	COG2851	Citrate transporter
ISN31_19920	COG0642	Histidine kinase
ISN31_19940	COG4191	Histidine kinase
ISN31_19950	COG1301	dicarboxylic acid transport
ISN31_19955	COG0281	malic enzyme
ISN31_19955	COG0280	phosphate acetyltransferase
ISN31_20020	COG1560	Kdo2-lipid A biosynthetic process
ISN31_20025	COG1519	Transferase
ISN31_20030	COG1538	Outer membrane efflux protein
ISN31_20035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN31_20045	COG3706	GGDEF domain
ISN31_20050	COG0473	3-isopropylmalate dehydrogenase activity
ISN31_20055	COG0066	3-isopropylmalate dehydratase activity
ISN31_20065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN31_20075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN31_20095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN31_20100	COG0840	transmembrane signaling receptor activity
ISN31_20120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN31_20130	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN31_20150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN31_20165	COG0671	phosphoesterase, PA-phosphatase related
ISN31_20180	COG1940	carbohydrate kinase activity
ISN31_20190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN31_20200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN31_20225	COG1773	rubredoxin
ISN31_20240	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN31_20250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN31_20275	COG3079	Belongs to the UPF0149 family
ISN31_20280	COG0006	proline dipeptidase activity
ISN31_20285	COG0006	proline dipeptidase activity
ISN31_20305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN31_20310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN31_20315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN31_20320	COG1561	YicC-like family, N-terminal region
ISN31_20325	COG0194	GDP metabolic process
ISN31_20330	COG1758	RNA polymerase activity
ISN31_20335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN31_20345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN31_20355	COG0254	rRNA binding
ISN31_20360	COG0372	Belongs to the citrate synthase family
ISN31_20375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN31_20405	COG0714	Associated with various cellular activities
ISN31_20435	COG1301	dicarboxylic acid transport
ISN31_20440	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN31_20475	COG0739	heme binding
ISN31_20480	COG1376	ErfK ybiS ycfS ynhG family protein
ISN31_20505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN31_20510	COG4149	molybdate abc transporter
ISN31_20515	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN31_20525	COG0640	Transcriptional regulator
ISN31_20550	COG3047	cAMP biosynthetic process
ISN31_20555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN31_20605	COG3588	fructose-bisphosphate aldolase
ISN31_20610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN31_20645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN31_20675	COG2198	Histidine kinase
ISN31_20675	COG2205	protein histidine kinase activity
ISN31_20675	COG0784	Response regulator, receiver
ISN31_20680	COG1393	Belongs to the ArsC family
ISN31_20710	COG0175	sulfate reduction