locus-tag	class	description
ISN32_00030	COG1064	alcohol dehydrogenase
ISN32_00035	COG2234	aminopeptidase activity
ISN32_00045	COG4942	peptidase
ISN32_00050	COG0793	Belongs to the peptidase S41A family
ISN32_00095	COG1486	melibiose metabolic process
ISN32_00110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN32_00110	COG1565	acr, cog1565
ISN32_00115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN32_00120	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN32_00150	COG0109	protoheme IX farnesyltransferase activity
ISN32_00165	COG0358	DNA primase activity
ISN32_00170	COG1295	ribonuclease BN
ISN32_00190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN32_00210	COG2308	Evidence 4 Homologs of previously reported genes of
ISN32_00225	COG2133	pyrroloquinoline quinone binding
ISN32_00245	COG0531	amino acid
ISN32_00255	COG4948	Mandelate Racemase Muconate Lactonizing
ISN32_00265	COG4771	TonB-dependent receptor
ISN32_00295	COG3409	Peptidoglycan-binding domain 1 protein
ISN32_00295	COG3501	Rhs element vgr protein
ISN32_00330	COG5383	Protein conserved in bacteria
ISN32_00345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_00350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_00365	COG1652	LysM domain
ISN32_00375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN32_00380	COG1518	maintenance of DNA repeat elements
ISN32_00430	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN32_00460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN32_00465	COG3118	belongs to the thioredoxin family
ISN32_00475	COG2884	Cell division ATP-binding protein ftsE
ISN32_00480	COG2177	Part of the ABC transporter FtsEX involved in
ISN32_00485	COG2201	protein-glutamate methylesterase activity
ISN32_00490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN32_00495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN32_00500	COG2860	membrane
ISN32_00505	COG1252	NADH dehydrogenase
ISN32_00515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN32_00525	COG0534	Mate efflux family protein
ISN32_00530	COG0616	signal peptide processing
ISN32_00540	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_00555	COG0009	L-threonylcarbamoyladenylate synthase
ISN32_00560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN32_00560	COG1754	DNA topoisomerase type I activity
ISN32_00565	COG1714	RDD family
ISN32_00580	COG0758	DNA mediated transformation
ISN32_00585	COG1652	LysM domain
ISN32_00590	COG0242	peptide deformylase activity
ISN32_00595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN32_00600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN32_00600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN32_00605	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN32_00615	COG3307	-O-antigen
ISN32_00640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN32_00655	COG1490	D-aminoacyl-tRNA deacylase activity
ISN32_00660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN32_00690	COG1609	Transcriptional regulator
ISN32_00700	COG0366	Alpha amylase catalytic
ISN32_00705	COG0366	Alpha amylase catalytic
ISN32_00755	COG1309	transcriptional regulator
ISN32_00795	COG0840	transmembrane signaling receptor activity
ISN32_00815	COG3546	catalase activity
ISN32_00820	COG3685	Protein conserved in bacteria
ISN32_00825	COG3685	Protein conserved in bacteria
ISN32_00830	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_00840	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN32_00855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN32_00870	COG0028	Belongs to the TPP enzyme family
ISN32_00875	COG4191	Histidine kinase
ISN32_00880	COG2204	response regulator
ISN32_00910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN32_00915	COG0732	type I restriction modification DNA specificity domain
ISN32_00925	COG3645	SOS response
ISN32_00955	COG1116	anion transmembrane transporter activity
ISN32_00955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN32_00960	COG2223	nitrite transmembrane transporter activity
ISN32_00965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN32_00970	COG2146	nitrite reductase [NAD(P)H] activity
ISN32_00975	COG0243	molybdopterin cofactor binding
ISN32_01000	COG1640	4-alpha-glucanotransferase
ISN32_01005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN32_01050	COG0181	hydroxymethylbilane synthase activity
ISN32_01070	COG1733	regulation of RNA biosynthetic process
ISN32_01085	COG1505	serine-type exopeptidase activity
ISN32_01090	COG0436	Aminotransferase
ISN32_01100	COG2832	Protein of unknown function (DUF454)
ISN32_01110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN32_01155	COG2226	methyltransferase
ISN32_01165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN32_01170	COG0308	aminopeptidase N
ISN32_01175	COG0596	Alpha beta hydrolase
ISN32_01175	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN32_01200	COG2010	Cytochrome c
ISN32_01210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN32_01220	COG3284	Transcriptional regulator
ISN32_01225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN32_01230	COG1077	Cell shape determining protein MreB Mrl
ISN32_01235	COG1792	Involved in formation and maintenance of cell shape
ISN32_01245	COG0768	penicillin binding
ISN32_01250	COG0772	Belongs to the SEDS family
ISN32_01265	COG2951	lytic endotransglycosylase activity
ISN32_01275	COG1686	Belongs to the peptidase S11 family
ISN32_01310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN32_01340	COG1056	cytidyltransferase-related domain
ISN32_01340	COG1051	belongs to the nudix hydrolase family
ISN32_01360	COG1090	epimerase
ISN32_01370	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN32_01375	COG0673	inositol 2-dehydrogenase activity
ISN32_01380	COG2823	Periplasmic or secreted lipoprotein
ISN32_01390	COG2205	protein histidine kinase activity
ISN32_01390	COG2202	Pas domain
ISN32_01395	COG0784	Response regulator, receiver
ISN32_01400	COG4191	Histidine kinase
ISN32_01410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN32_01415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_01430	COG4305	rare lipoprotein A
ISN32_01450	COG3250	beta-galactosidase activity
ISN32_01465	COG2188	Transcriptional regulator
ISN32_01470	COG0738	Major facilitator superfamily
ISN32_01475	COG1609	Transcriptional regulator
ISN32_01480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN32_01485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN32_01495	COG0617	tRNA 3'-terminal CCA addition
ISN32_01515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN32_01565	COG2205	protein histidine kinase activity
ISN32_01580	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN32_01585	COG3791	Glutathione-dependent formaldehyde-activating
ISN32_01595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN32_01640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN32_01660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN32_01760	COG1162	GTPase activity
ISN32_01785	COG2211	Major facilitator Superfamily
ISN32_01795	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_01800	COG2851	Citrate transporter
ISN32_01815	COG0642	Histidine kinase
ISN32_01835	COG4191	Histidine kinase
ISN32_01845	COG1301	dicarboxylic acid transport
ISN32_01850	COG0281	malic enzyme
ISN32_01850	COG0280	phosphate acetyltransferase
ISN32_01915	COG1560	Kdo2-lipid A biosynthetic process
ISN32_01920	COG1519	Transferase
ISN32_01925	COG1538	Outer membrane efflux protein
ISN32_01930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN32_01935	COG1309	transcriptional regulator
ISN32_01940	COG3706	GGDEF domain
ISN32_01945	COG0473	3-isopropylmalate dehydrogenase activity
ISN32_01950	COG0066	3-isopropylmalate dehydratase activity
ISN32_01970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN32_01990	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN32_01995	COG0840	transmembrane signaling receptor activity
ISN32_02020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN32_02030	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN32_02050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN32_02060	COG0671	phosphoesterase, PA-phosphatase related
ISN32_02075	COG1940	carbohydrate kinase activity
ISN32_02085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN32_02105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN32_02130	COG1773	rubredoxin
ISN32_02145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN32_02155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN32_02180	COG3079	Belongs to the UPF0149 family
ISN32_02185	COG0006	proline dipeptidase activity
ISN32_02190	COG0006	proline dipeptidase activity
ISN32_02210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN32_02215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN32_02220	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN32_02225	COG1561	YicC-like family, N-terminal region
ISN32_02230	COG0194	GDP metabolic process
ISN32_02235	COG1758	RNA polymerase activity
ISN32_02240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN32_02250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN32_02260	COG0254	rRNA binding
ISN32_02265	COG0372	Belongs to the citrate synthase family
ISN32_02280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN32_02310	COG0714	Associated with various cellular activities
ISN32_02340	COG1301	dicarboxylic acid transport
ISN32_02345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN32_02375	COG0739	heme binding
ISN32_02380	COG1376	ErfK ybiS ycfS ynhG family protein
ISN32_02415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN32_02420	COG4149	molybdate abc transporter
ISN32_02425	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN32_02435	COG0640	Transcriptional regulator
ISN32_02460	COG3047	cAMP biosynthetic process
ISN32_02465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN32_02510	COG0469	pyruvate kinase activity
ISN32_02515	COG3588	fructose-bisphosphate aldolase
ISN32_02520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN32_02555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN32_02570	COG1648	precorrin-2 dehydrogenase activity
ISN32_02570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN32_02585	COG2205	protein histidine kinase activity
ISN32_02585	COG2198	Histidine kinase
ISN32_02585	COG0784	Response regulator, receiver
ISN32_02590	COG1393	Belongs to the ArsC family
ISN32_02620	COG0175	sulfate reduction
ISN32_02625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN32_02630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN32_02640	COG2895	sulfate adenylyltransferase (ATP) activity
ISN32_02640	COG0529	Catalyzes the synthesis of activated sulfate
ISN32_02645	COG0840	transmembrane signaling receptor activity
ISN32_02665	COG1115	amino acid carrier protein
ISN32_02675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN32_02690	COG1609	Transcriptional regulator
ISN32_02710	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN32_02725	COG3273	potassium ion transport
ISN32_02725	COG0471	metal ion transport
ISN32_02735	COG2022	thiamine diphosphate biosynthetic process
ISN32_02755	COG0174	glutamine synthetase
ISN32_02760	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN32_02770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN32_02785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN32_02810	COG3511	phospholipase C
ISN32_02820	COG0189	ligase activity
ISN32_02830	COG0745	RESPONSE REGULATOR receiver
ISN32_02845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN32_02905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN32_02905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN32_02915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN32_02930	COG1174	glycine betaine transport
ISN32_02935	COG1125	glycine betaine transport
ISN32_02945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_02950	COG0564	pseudouridine synthase activity
ISN32_02975	COG3387	PFAM Glycoside hydrolase 15-related
ISN32_03025	COG0542	response to heat
ISN32_03050	COG0019	diaminopimelate decarboxylase activity
ISN32_03055	COG4264	IucA IucC family
ISN32_03060	COG2814	Major facilitator Superfamily
ISN32_03065	COG4264	IucA IucC family
ISN32_03075	COG4772	TonB-dependent receptor
ISN32_03085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN32_03085	COG4651	solute:proton antiporter activity
ISN32_03145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_03145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_03165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN32_03205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN32_03210	COG1404	Belongs to the peptidase S8 family
ISN32_03245	COG1295	ribonuclease BN
ISN32_03250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN32_03270	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN32_03275	COG5297	Belongs to the glycosyl hydrolase family 6
ISN32_03365	COG3537	Alpha-1,2-mannosidase
ISN32_03390	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_03400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN32_03405	COG3858	chitin binding
ISN32_03405	COG1388	LysM domain
ISN32_03420	COG0837	glucose binding
ISN32_03430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN32_03440	COG0494	nUDIX hydrolase
ISN32_03445	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN32_03450	COG3956	TIGRFAM MazG family protein
ISN32_03455	COG1742	UPF0060 membrane protein
ISN32_03460	COG0330	HflC and HflK could
ISN32_03495	COG0697	spore germination
ISN32_03525	COG2124	cytochrome p450
ISN32_03530	COG2124	cytochrome p450
ISN32_03535	COG1141	Ferredoxin
ISN32_03540	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_03545	COG2124	cytochrome p450
ISN32_03550	COG0142	geranyltranstransferase activity
ISN32_03555	COG1657	PFAM Prenyltransferase squalene oxidase
ISN32_03565	COG1304	FMN binding
ISN32_03585	COG4206	TonB-dependent receptor
ISN32_03595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN32_03600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN32_03605	COG0463	Glycosyl transferase, family 2
ISN32_03610	COG0517	IMP dehydrogenase activity
ISN32_03615	COG2982	Protein involved in outer membrane biogenesis
ISN32_03620	COG1272	protein, Hemolysin III
ISN32_03625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN32_03635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN32_03640	COG0626	cystathionine gamma-synthase activity
ISN32_03645	COG0527	aspartate kinase activity
ISN32_03645	COG0460	homoserine dehydrogenase
ISN32_03650	COG2267	carboxylic ester hydrolase activity
ISN32_03660	COG1760	l-serine dehydratase
ISN32_03675	COG3038	cytochrome b561
ISN32_03695	COG2814	Major facilitator Superfamily
ISN32_03700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN32_03710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_03715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_03790	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_03805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN32_03825	COG0840	transmembrane signaling receptor activity
ISN32_03835	COG1113	amino acid transport
ISN32_03855	COG2239	Acts as a magnesium transporter
ISN32_03860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN32_03865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN32_03875	COG1660	Displays ATPase and GTPase activities
ISN32_03885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN32_03900	COG1137	ATPase activity
ISN32_03915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN32_03960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN32_03985	COG0628	permease
ISN32_03995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN32_04000	COG3178	'Phosphotransferase
ISN32_04015	COG1555	photosystem II stabilization
ISN32_04035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN32_04040	COG1477	protein flavinylation
ISN32_04065	COG4774	siderophore transport
ISN32_04070	COG2146	nitrite reductase [NAD(P)H] activity
ISN32_04080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN32_04085	COG0719	Fe-S assembly protein
ISN32_04090	COG0396	ATPase activity
ISN32_04095	COG0719	Fe-S assembly protein
ISN32_04110	COG0693	protein deglycase activity
ISN32_04125	COG0739	heme binding
ISN32_04140	COG1764	response to oxidative stress
ISN32_04150	COG0384	phenazine biosynthesis protein PhzF
ISN32_04155	COG0527	aspartate kinase activity
ISN32_04180	COG0142	geranyltranstransferase activity
ISN32_04185	COG0629	single-stranded DNA binding
ISN32_04190	COG3550	peptidyl-serine autophosphorylation
ISN32_04205	COG3104	oligopeptide transport
ISN32_04210	COG1297	OPT oligopeptide transporter protein
ISN32_04215	COG1506	peptidase
ISN32_04215	COG0823	Involved in the tonB-independent uptake of proteins
ISN32_04235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN32_04240	COG2879	small protein
ISN32_04245	COG1966	Carbon starvation protein
ISN32_04280	COG2211	Major facilitator Superfamily
ISN32_04310	COG5001	Diguanylate cyclase
ISN32_04310	COG4251	negative regulation of phosphorylation
ISN32_04310	COG2203	Gaf domain
ISN32_04310	COG3706	GGDEF domain
ISN32_04315	COG0835	chemotaxis
ISN32_04320	COG0840	transmembrane signaling receptor activity
ISN32_04325	COG0840	transmembrane signaling receptor activity
ISN32_04330	COG0840	transmembrane signaling receptor activity
ISN32_04335	COG0643	Histidine kinase
ISN32_04335	COG2198	Histidine kinase
ISN32_04345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN32_04365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN32_04375	COG2205	protein histidine kinase activity
ISN32_04415	COG0735	belongs to the Fur family
ISN32_04450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN32_04455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN32_04460	COG2080	2 iron, 2 sulfur cluster binding
ISN32_04545	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_04570	COG1187	pseudouridine synthase activity
ISN32_04595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN32_04620	COG1132	(ABC) transporter
ISN32_04645	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_04650	COG0583	DNA-binding transcription factor activity
ISN32_04690	COG1981	membrane
ISN32_04715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_04720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_04730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_04735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_04740	COG0750	zinc metalloprotease
ISN32_04745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN32_04750	COG0575	Belongs to the CDS family
ISN32_04755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN32_04765	COG0528	UMP kinase activity
ISN32_04775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN32_04815	COG0024	Methionine aminopeptidase
ISN32_04830	COG1393	Belongs to the ArsC family
ISN32_04835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN32_04845	COG0367	asparagine synthase
ISN32_04880	COG1566	PFAM secretion protein HlyD family protein
ISN32_04885	COG2814	Major facilitator Superfamily
ISN32_04920	COG0557	exoribonuclease II activity
ISN32_04930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN32_04940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN32_04960	COG0704	Plays a role in the regulation of phosphate uptake
ISN32_04970	COG0581	inorganic phosphate transmembrane transporter activity
ISN32_04980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN32_04985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN32_05005	COG0659	secondary active sulfate transmembrane transporter activity
ISN32_05010	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN32_05020	COG1024	Enoyl-CoA hydratase
ISN32_05075	COG5002	protein histidine kinase activity
ISN32_05075	COG0784	Response regulator, receiver
ISN32_05075	COG2205	protein histidine kinase activity
ISN32_05080	COG2733	membrane
ISN32_05100	COG0686	Belongs to the AlaDH PNT family
ISN32_05105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN32_05110	COG1917	Cupin 2, conserved barrel domain protein
ISN32_05110	COG1396	sequence-specific DNA binding
ISN32_05115	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_05135	COG2223	nitrite transmembrane transporter activity
ISN32_05145	COG0243	molybdopterin cofactor binding
ISN32_05160	COG0477	Major facilitator Superfamily
ISN32_05170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_05175	COG0174	glutamine synthetase
ISN32_05180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN32_05185	COG0174	glutamine synthetase
ISN32_05195	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN32_05220	COG3842	ATPase activity
ISN32_05225	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN32_05230	COG1177	transmembrane transport
ISN32_05235	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_05250	COG4535	Mg2 and Co2 transporter CorC
ISN32_05265	COG1702	phosphate starvation-inducible protein PhoH
ISN32_05280	COG0741	lytic transglycosylase activity
ISN32_05285	COG0723	plastoquinol--plastocyanin reductase activity
ISN32_05290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN32_05300	COG2857	Cytochrome c1
ISN32_05305	COG0625	glutathione transferase activity
ISN32_05310	COG2969	positive regulation of protein catabolic process
ISN32_05350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN32_05355	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_05360	COG2095	MarC family integral membrane protein
ISN32_05370	COG1611	Belongs to the LOG family
ISN32_05375	COG3275	phosphorelay sensor kinase activity
ISN32_05600	COG3179	chitinase
ISN32_05645	COG4695	Portal protein
ISN32_05710	COG0556	nucleotide-excision repair
ISN32_05740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN32_05750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN32_05755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN32_05805	COG0438	transferase activity, transferring glycosyl groups
ISN32_05810	COG0438	transferase activity, transferring glycosyl groups
ISN32_05820	COG0438	transferase activity, transferring glycosyl groups
ISN32_05840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN32_05850	COG1960	acyl-CoA dehydrogenase activity
ISN32_05885	COG1570	exodeoxyribonuclease VII activity
ISN32_05890	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN32_05895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN32_05895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN32_05900	COG0802	atpase or kinase
ISN32_05905	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN32_05910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN32_05930	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_05950	COG2081	HI0933 family
ISN32_05955	COG4681	YaeQ
ISN32_05960	COG0564	pseudouridine synthase activity
ISN32_05970	COG0625	glutathione transferase activity
ISN32_05975	COG0657	acetylesterase activity
ISN32_05980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN32_06005	COG0513	Belongs to the DEAD box helicase family
ISN32_06010	COG0488	(ABC) transporter
ISN32_06025	COG4290	ribonuclease
ISN32_06030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN32_06040	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_06080	COG1846	Transcriptional regulator
ISN32_06095	COG0386	Belongs to the glutathione peroxidase family
ISN32_06120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISN32_06170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN32_06175	COG0084	hydrolase, TatD family'
ISN32_06190	COG1960	acyl-CoA dehydrogenase activity
ISN32_06200	COG0305	Participates in initiation and elongation during chromosome replication
ISN32_06205	COG0415	Belongs to the DNA photolyase family
ISN32_06220	COG0583	DNA-binding transcription factor activity
ISN32_06235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_06275	COG1404	Belongs to the peptidase S8 family
ISN32_06280	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN32_06285	COG2867	negative regulation of translational initiation
ISN32_06295	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_06300	COG0735	belongs to the Fur family
ISN32_06305	COG0497	DNA recombination
ISN32_06310	COG1420	regulation of RNA biosynthetic process
ISN32_06315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN32_06320	COG0443	Heat shock 70 kDa protein
ISN32_06325	COG0484	heat shock protein binding
ISN32_06330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN32_06335	COG1605	Chorismate mutase
ISN32_06335	COG0287	Prephenate dehydrogenase
ISN32_06345	COG1132	(ABC) transporter
ISN32_06370	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_06380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN32_06410	COG2166	iron-sulfur cluster assembly
ISN32_06425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN32_06430	COG0137	argininosuccinate synthase activity
ISN32_06435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN32_06440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN32_06450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN32_06455	COG0165	Argininosuccinate lyase
ISN32_06475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN32_06500	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN32_06510	COG1070	Carbohydrate kinase
ISN32_06515	COG2115	Belongs to the xylose isomerase family
ISN32_06520	COG0477	Major facilitator Superfamily
ISN32_06525	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN32_06545	COG0617	tRNA 3'-terminal CCA addition
ISN32_06555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN32_06570	COG0166	Belongs to the GPI family
ISN32_06645	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN32_06660	COG0671	phosphoesterase, PA-phosphatase related
ISN32_06685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN32_06690	COG0167	dihydroorotate dehydrogenase activity
ISN32_06705	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_06720	COG0527	aspartate kinase activity
ISN32_06720	COG0460	homoserine dehydrogenase
ISN32_06730	COG2951	lytic endotransglycosylase activity
ISN32_06740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN32_06755	COG0124	histidyl-tRNA synthetase
ISN32_06765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN32_06770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN32_06775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN32_06785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN32_06800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN32_06800	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN32_06815	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN32_06820	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN32_06825	COG0235	Class ii aldolase
ISN32_06830	COG0531	amino acid
ISN32_06835	COG0531	amino acid
ISN32_06850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN32_06855	COG0277	FAD linked oxidase domain protein
ISN32_06875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN32_06890	COG1024	Enoyl-CoA hydratase
ISN32_06945	COG1741	Belongs to the pirin family
ISN32_06950	COG0583	DNA-binding transcription factor activity
ISN32_06970	COG0352	thiamine-phosphate diphosphorylase activity
ISN32_06970	COG0351	phosphomethylpyrimidine kinase
ISN32_06985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN32_06990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN32_07000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN32_07010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN32_07015	COG3734	2-keto-3-deoxy-galactonokinase
ISN32_07030	COG0800	Aldolase
ISN32_07065	COG2198	Histidine kinase
ISN32_07065	COG0784	Response regulator, receiver
ISN32_07065	COG2205	protein histidine kinase activity
ISN32_07070	COG1024	Enoyl-CoA hydratase
ISN32_07075	COG0318	PFAM AMP-dependent synthetase and ligase
ISN32_07130	COG0840	transmembrane signaling receptor activity
ISN32_07140	COG0840	transmembrane signaling receptor activity
ISN32_07150	COG0835	chemotaxis
ISN32_07160	COG0840	transmembrane signaling receptor activity
ISN32_07170	COG0840	transmembrane signaling receptor activity
ISN32_07175	COG0840	transmembrane signaling receptor activity
ISN32_07180	COG0840	transmembrane signaling receptor activity
ISN32_07185	COG0840	transmembrane signaling receptor activity
ISN32_07195	COG0840	transmembrane signaling receptor activity
ISN32_07200	COG0840	transmembrane signaling receptor activity
ISN32_07205	COG0840	transmembrane signaling receptor activity
ISN32_07210	COG0840	transmembrane signaling receptor activity
ISN32_07225	COG0745	RESPONSE REGULATOR receiver
ISN32_07235	COG0835	chemotaxis
ISN32_07240	COG1192	Involved in chromosome partitioning
ISN32_07250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN32_07255	COG0784	Response regulator, receiver
ISN32_07255	COG0643	Histidine kinase
ISN32_07255	COG2198	Histidine kinase
ISN32_07260	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN32_07305	COG1684	flagellar biosynthetic protein fliR
ISN32_07310	COG1987	bacterial-type flagellum assembly
ISN32_07320	COG3190	flagellar
ISN32_07370	COG1677	Flagellar hook-basal body complex protein FliE
ISN32_07415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_07420	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_07425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_07445	COG2201	protein-glutamate methylesterase activity
ISN32_07450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISN32_07455	COG2197	response regulator
ISN32_07475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN32_07480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN32_07485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN32_07490	COG1256	bacterial-type flagellum assembly
ISN32_07490	COG4786	Flagellar basal body rod
ISN32_07490	COG1256	bacterial-type flagellum assembly
ISN32_07490	COG4786	Flagellar basal body rod
ISN32_07505	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN32_07520	COG1749	Flagellar hook protein flgE
ISN32_07530	COG1558	bacterial-type flagellum-dependent cell motility
ISN32_07540	COG0835	chemotaxis
ISN32_07540	COG0784	Response regulator, receiver
ISN32_07605	COG2915	High frequency lysogenization protein hflD homolog
ISN32_07610	COG0482	sulfurtransferase activity
ISN32_07630	COG0542	response to heat
ISN32_07650	COG0492	ferredoxin-NADP+ reductase activity
ISN32_07655	COG1674	ftsk spoiiie
ISN32_07675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN32_07680	COG0038	chloride channel
ISN32_07735	COG1595	DNA-templated transcription, initiation
ISN32_07755	COG3038	cytochrome b561
ISN32_07785	COG2244	polysaccharide biosynthetic process
ISN32_07805	COG4106	trans-aconitate 2-methyltransferase activity
ISN32_07825	COG0438	transferase activity, transferring glycosyl groups
ISN32_07830	COG0438	transferase activity, transferring glycosyl groups
ISN32_07850	COG1132	(ABC) transporter
ISN32_07880	COG2801	Transposase and inactivated derivatives
ISN32_07885	COG1022	Amp-dependent synthetase and ligase
ISN32_07920	COG0512	Glutamine amidotransferase of anthranilate synthase
ISN32_07940	COG2801	Transposase and inactivated derivatives
ISN32_07965	COG1530	ribonuclease E activity
ISN32_07980	COG0428	transporter
ISN32_07995	COG0316	Belongs to the HesB IscA family
ISN32_07995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN32_08015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_08035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN32_08040	COG2957	Belongs to the agmatine deiminase family
ISN32_08050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN32_08055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN32_08060	COG0539	negative regulation of cytoplasmic translation
ISN32_08065	COG0776	regulation of translation
ISN32_08075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN32_08080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN32_08090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN32_08095	COG0183	Belongs to the thiolase family
ISN32_08100	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN32_08100	COG1024	Enoyl-CoA hydratase
ISN32_08115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN32_08125	COG1426	Protein conserved in bacteria
ISN32_08135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN32_08145	COG0746	molybdenum cofactor guanylyltransferase activity
ISN32_08155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN32_08160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN32_08160	COG0475	glutathione-regulated potassium exporter activity
ISN32_08180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN32_08190	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_08190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_08220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_08220	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_08220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_08220	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_08295	COG1487	ribonuclease activity
ISN32_08300	COG4691	Plasmid stability protein
ISN32_08355	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN32_08360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN32_08370	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN32_08385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN32_08390	COG0668	transmembrane transport
ISN32_08400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN32_08415	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_08420	COG1183	phosphatidylcholine synthase activity
ISN32_08430	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN32_08450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_08450	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN32_08460	COG0784	Response regulator, receiver
ISN32_08460	COG4191	Histidine kinase
ISN32_08465	COG2183	response to ionizing radiation
ISN32_08540	COG1649	PFAM Uncharacterised BCR, COG1649
ISN32_08545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN32_08550	COG1304	FMN binding
ISN32_08560	COG0346	lactoylglutathione lyase activity
ISN32_08575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN32_08600	COG1024	Enoyl-CoA hydratase
ISN32_08605	COG1024	Enoyl-CoA hydratase
ISN32_08615	COG1024	Enoyl-CoA hydratase
ISN32_08635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN32_08650	COG1247	-acetyltransferase
ISN32_08660	COG0653	protein targeting
ISN32_08675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN32_08680	COG1393	Belongs to the ArsC family
ISN32_08685	COG0431	NADPH-dependent FMN reductase
ISN32_08690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISN32_08710	COG4644	lycopene metabolic process
ISN32_08785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISN32_08795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN32_08800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN32_08810	COG0505	Belongs to the CarA family
ISN32_08820	COG2258	MOSC domain
ISN32_08825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN32_08855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN32_08865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN32_08870	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN32_09025	COG3179	chitinase
ISN32_09180	COG2801	Transposase and inactivated derivatives
ISN32_09190	COG2963	transposase activity
ISN32_09205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN32_09220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN32_09230	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN32_09235	COG1132	(ABC) transporter
ISN32_09245	COG0811	peptide transport
ISN32_09265	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN32_09275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN32_09290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN32_09295	COG2009	succinate dehydrogenase
ISN32_09310	COG3842	ATPase activity
ISN32_09315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN32_09330	COG0129	dihydroxy-acid dehydratase activity
ISN32_09345	COG0395	ABC-type sugar transport system, permease component
ISN32_09380	COG2350	Protein conserved in bacteria
ISN32_09385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN32_09390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN32_09395	COG1187	pseudouridine synthase activity
ISN32_09420	COG0436	Aminotransferase
ISN32_09425	COG4133	protoheme IX ABC transporter activity
ISN32_09475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN32_09480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN32_09485	COG4988	ABC transporter
ISN32_09495	COG1294	oxidase, subunit
ISN32_09545	COG2137	regulation of response to DNA damage stimulus
ISN32_09550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN32_09555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN32_09560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN32_09565	COG1546	Belongs to the CinA family
ISN32_09570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN32_09580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN32_09585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN32_09590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN32_09595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN32_09600	COG1534	Rna-binding protein
ISN32_09615	COG1238	metal cluster binding
ISN32_09625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN32_09640	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN32_09645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN32_09650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISN32_09665	COG0504	CTP synthase activity
ISN32_09685	COG0306	phosphate transporter
ISN32_09695	COG1253	flavin adenine dinucleotide binding
ISN32_09710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN32_09745	COG0069	glutamate synthase activity
ISN32_09750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN32_09760	COG1609	Transcriptional regulator
ISN32_09765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN32_09765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN32_09770	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN32_09775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN32_09775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN32_09805	COG0577	efflux transmembrane transporter activity
ISN32_09805	COG1136	(ABC) transporter
ISN32_09865	COG0583	DNA-binding transcription factor activity
ISN32_09890	COG0077	Prephenate dehydratase
ISN32_09890	COG1605	Chorismate mutase
ISN32_09895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN32_09900	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN32_09940	COG4221	oxidoreductase activity
ISN32_09955	COG1228	amidohydrolase
ISN32_09970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN32_10005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN32_10015	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN32_10025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN32_10060	COG0316	Belongs to the HesB IscA family
ISN32_10130	COG0288	reversible hydration of carbon dioxide
ISN32_10140	COG1289	transmembrane transporter activity
ISN32_10145	COG3844	kynureninase activity
ISN32_10155	COG2925	Exonuclease
ISN32_10205	COG2902	Dehydrogenase
ISN32_10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_10220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_10225	COG1960	acyl-CoA dehydrogenase activity
ISN32_10230	COG2226	methyltransferase
ISN32_10235	COG0646	methionine synthase
ISN32_10235	COG1410	methionine synthase
ISN32_10240	COG0646	methionine synthase
ISN32_10240	COG1410	methionine synthase
ISN32_10250	COG2755	lipolytic protein G-D-S-L family
ISN32_10250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN32_10260	COG2900	Belongs to the SlyX family
ISN32_10275	COG0386	Belongs to the glutathione peroxidase family
ISN32_10285	COG1725	Transcriptional regulator
ISN32_10290	COG1131	(ABC) transporter
ISN32_10330	COG2850	peptidyl-arginine hydroxylation
ISN32_10360	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_10365	COG4677	pectinesterase activity
ISN32_10395	COG0402	S-adenosylhomocysteine deaminase activity
ISN32_10400	COG3548	integral membrane protein
ISN32_10410	COG1509	lysine 2,3-aminomutase activity
ISN32_10415	COG3706	GGDEF domain
ISN32_10415	COG4251	negative regulation of phosphorylation
ISN32_10415	COG5001	Diguanylate cyclase
ISN32_10415	COG2203	Gaf domain
ISN32_10440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN32_10445	COG1862	Preprotein translocase
ISN32_10455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN32_10465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN32_10475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN32_10480	COG3291	Pkd domain containing protein
ISN32_10485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN32_10490	COG0405	Gamma-glutamyltransferase
ISN32_10495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN32_10510	COG0742	ribosomal rna small subunit methyltransferase
ISN32_10535	COG4771	TonB-dependent receptor
ISN32_10545	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN32_10580	COG0531	amino acid
ISN32_10595	COG0006	proline dipeptidase activity
ISN32_10605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN32_10620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_10625	COG3938	Belongs to the proline racemase family
ISN32_10635	COG0552	protein localization to endoplasmic reticulum
ISN32_10640	COG1194	a g-specific adenine glycosylase
ISN32_10685	COG0835	chemotaxis
ISN32_10690	COG0840	transmembrane signaling receptor activity
ISN32_10695	COG0840	transmembrane signaling receptor activity
ISN32_10715	COG5001	Diguanylate cyclase
ISN32_10715	COG3300	MHYT domain
ISN32_10720	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN32_10730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISN32_10745	COG0195	Participates in both transcription termination and antitermination
ISN32_10760	COG1007	ATP synthesis coupled electron transport
ISN32_10800	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN32_10805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN32_10810	COG0649	NAD binding
ISN32_10815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN32_10825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN32_10855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN32_10920	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN32_10930	COG0688	phosphatidylethanolamine metabolic process
ISN32_10935	COG0741	lytic transglycosylase activity
ISN32_10940	COG0433	COG0433 Predicted ATPase
ISN32_10945	COG0494	nUDIX hydrolase
ISN32_10960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN32_10980	COG1714	RDD family
ISN32_10985	COG0717	Belongs to the dCTP deaminase family
ISN32_10990	COG0489	protein tyrosine kinase activity
ISN32_11000	COG4771	TonB-dependent receptor
ISN32_11010	COG4771	TonB-dependent receptor
ISN32_11015	COG0457	Tetratricopeptide repeat
ISN32_11030	COG3590	peptidase
ISN32_11070	COG0697	spore germination
ISN32_11090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_11095	COG2311	Membrane
ISN32_11100	COG1047	Peptidyl-prolyl cis-trans
ISN32_11105	COG0791	NLP P60 protein
ISN32_11110	COG0791	NLP P60 protein
ISN32_11125	COG1607	acyl-coa hydrolase
ISN32_11135	COG1301	dicarboxylic acid transport
ISN32_11140	COG1785	Belongs to the alkaline phosphatase family
ISN32_11150	COG0037	tRNA processing
ISN32_11155	COG1722	exodeoxyribonuclease VII activity
ISN32_11160	COG0142	geranyltranstransferase activity
ISN32_11170	COG1858	cytochrome C peroxidase
ISN32_11195	COG0515	serine threonine protein kinase
ISN32_11195	COG2815	serine threonine protein kinase
ISN32_11200	COG0631	protein serine/threonine phosphatase activity
ISN32_11290	COG0312	modulator of DNA gyrase
ISN32_11300	COG0312	modulator of DNA gyrase
ISN32_11320	COG2968	Membrane
ISN32_11335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN32_11350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN32_11365	COG0495	leucyl-tRNA aminoacylation
ISN32_11375	COG3118	belongs to the thioredoxin family
ISN32_11390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN32_11400	COG2040	homocysteine
ISN32_11405	COG0833	amino acid
ISN32_11415	COG0346	lactoylglutathione lyase activity
ISN32_11435	COG2878	Part of a membrane complex involved in electron transport
ISN32_11450	COG1595	DNA-templated transcription, initiation
ISN32_11475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN32_11495	COG0251	oxidation-reduction process
ISN32_11505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN32_11505	COG0392	lysyltransferase activity
ISN32_11535	COG2814	Major facilitator Superfamily
ISN32_11540	COG1902	pentaerythritol trinitrate reductase activity
ISN32_11545	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN32_11550	COG1047	Peptidyl-prolyl cis-trans
ISN32_11555	COG1077	Cell shape determining protein MreB Mrl
ISN32_11590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN32_11600	COG1451	nucleotide metabolic process
ISN32_11620	COG0784	Response regulator, receiver
ISN32_11620	COG2205	protein histidine kinase activity
ISN32_11620	COG2198	Histidine kinase
ISN32_11630	COG2186	Transcriptional regulator
ISN32_11635	COG3250	beta-galactosidase activity
ISN32_11700	COG1703	isobutyryl-CoA mutase activity
ISN32_11700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN32_11700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN32_11730	COG0183	Belongs to the thiolase family
ISN32_11740	COG0443	Heat shock 70 kDa protein
ISN32_11770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN32_11770	COG1793	dna ligase
ISN32_11775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN32_11775	COG1793	dna ligase
ISN32_11780	COG1201	RNA secondary structure unwinding
ISN32_11790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN32_11795	COG1278	Cold shock
ISN32_11800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN32_11805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN32_11810	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_11820	COG2954	triphosphatase activity
ISN32_11830	COG0745	RESPONSE REGULATOR receiver
ISN32_11840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN32_11855	COG0681	Belongs to the peptidase S26 family
ISN32_11860	COG0481	GTPase activity
ISN32_11865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN32_11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN32_11880	COG1024	Enoyl-CoA hydratase
ISN32_11900	COG2855	membrane
ISN32_11915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN32_11945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN32_11955	COG0534	Mate efflux family protein
ISN32_11960	COG0335	large ribosomal subunit rRNA binding
ISN32_11965	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN32_11970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN32_11985	COG2070	2-Nitropropane dioxygenase
ISN32_11990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN32_12015	COG0475	glutathione-regulated potassium exporter activity
ISN32_12025	COG0625	glutathione transferase activity
ISN32_12030	COG1082	Xylose isomerase domain protein TIM barrel
ISN32_12040	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN32_12045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN32_12050	COG1129	ABC transporter
ISN32_12055	COG1879	ABC-type sugar transport system periplasmic component
ISN32_12060	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_12080	COG0129	dihydroxy-acid dehydratase activity
ISN32_12110	COG2207	Transcriptional regulator
ISN32_12155	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN32_12180	COG4794	Type iii secretion
ISN32_12210	COG0745	RESPONSE REGULATOR receiver
ISN32_12235	COG1595	DNA-templated transcription, initiation
ISN32_12265	COG0156	8-amino-7-oxononanoate synthase activity
ISN32_12275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN32_12280	COG1845	cytochrome c oxidase, subunit III
ISN32_12285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN32_12320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN32_12335	COG0196	riboflavin kinase activity
ISN32_12350	COG0728	peptidoglycan biosynthetic process
ISN32_12360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISN32_12365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN32_12370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN32_12375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN32_12380	COG0824	Thioesterase
ISN32_12390	COG1024	Enoyl-CoA hydratase
ISN32_12395	COG1946	Acyl-CoA thioesterase
ISN32_12410	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN32_12475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN32_12520	COG1643	Atp-dependent helicase
ISN32_12525	COG0783	Belongs to the Dps family
ISN32_12530	COG0514	ATP-dependent DNA helicase (RecQ)
ISN32_12550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN32_12555	COG0602	queuosine metabolic process
ISN32_12565	COG2885	chlorophyll binding
ISN32_12580	COG0848	biopolymer transport protein
ISN32_12590	COG0824	Thioesterase
ISN32_12595	COG2255	four-way junction helicase activity
ISN32_12600	COG3158	transport of potassium into the cell
ISN32_12605	COG0632	four-way junction helicase activity
ISN32_12615	COG0217	transcriptional regulatory protein
ISN32_12655	COG3142	Participates in the control of copper homeostasis
ISN32_12660	COG1446	asparaginase
ISN32_12690	COG2201	protein-glutamate methylesterase activity
ISN32_12695	COG0643	Histidine kinase
ISN32_12695	COG2198	Histidine kinase
ISN32_12695	COG0784	Response regulator, receiver
ISN32_12700	COG0840	transmembrane signaling receptor activity
ISN32_12705	COG0835	chemotaxis
ISN32_12720	COG0189	ligase activity
ISN32_12745	COG1199	ATP-dependent helicase activity
ISN32_12755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN32_12760	COG1216	Glycosyl transferase, family 2
ISN32_12770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISN32_12790	COG4585	Histidine kinase
ISN32_12800	COG0850	regulation of cytokinetic process
ISN32_12805	COG2894	cell division
ISN32_12810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN32_12820	COG2205	protein histidine kinase activity
ISN32_12825	COG0745	RESPONSE REGULATOR receiver
ISN32_12835	COG2194	sulfuric ester hydrolase activity
ISN32_12880	COG2814	Major facilitator Superfamily
ISN32_12905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN32_12905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN32_12920	COG0753	catalase activity
ISN32_12945	COG1063	alcohol dehydrogenase
ISN32_12955	COG3459	Glycosyltransferase 36 associated
ISN32_13070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN32_13080	COG0330	HflC and HflK could
ISN32_13085	COG0330	HflC and HflK could
ISN32_13090	COG0604	alcohol dehydrogenase
ISN32_13110	COG0678	peroxiredoxin activity
ISN32_13120	COG4953	penicillin-binding protein 1C
ISN32_13140	COG2373	Large extracellular alpha-helical protein
ISN32_13190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN32_13210	COG0372	Belongs to the citrate synthase family
ISN32_13260	COG2161	toxin-antitoxin pair type II binding
ISN32_13265	COG4115	mRNA cleavage
ISN32_13285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN32_13290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN32_13295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN32_13305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN32_13310	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_13315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN32_13320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_13330	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN32_13355	COG0714	Associated with various cellular activities
ISN32_13375	COG0537	adenosine 5'-monophosphoramidase activity
ISN32_13490	COG0314	molybdopterin synthase activity
ISN32_13495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN32_13500	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN32_13510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN32_13515	COG1234	tRNA 3'-trailer cleavage
ISN32_13525	COG0859	PFAM glycosyl transferase family 9
ISN32_13545	COG0631	protein serine/threonine phosphatase activity
ISN32_13550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN32_13555	COG0328	RNA-DNA hybrid ribonuclease activity
ISN32_13565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN32_13570	COG1388	LysM domain
ISN32_13570	COG3942	CHAP domain
ISN32_13605	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN32_13615	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN32_13660	COG0473	3-isopropylmalate dehydrogenase activity
ISN32_13675	COG4783	chaperone-mediated protein folding
ISN32_13690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN32_13695	COG0248	Ppx GppA phosphatase
ISN32_13700	COG0438	transferase activity, transferring glycosyl groups
ISN32_13710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN32_13720	COG2833	Protein of unknown function (DUF455)
ISN32_13740	COG0285	dihydrofolate synthase activity
ISN32_13745	COG0588	phosphoglycerate mutase activity
ISN32_13765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN32_13770	COG4208	sulfate ABC transporter
ISN32_13775	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN32_13780	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN32_13785	COG0156	8-amino-7-oxononanoate synthase activity
ISN32_13790	COG1187	pseudouridine synthase activity
ISN32_13800	COG2885	chlorophyll binding
ISN32_13820	COG0667	Aldo Keto reductase
ISN32_13830	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN32_13830	COG1902	pentaerythritol trinitrate reductase activity
ISN32_13875	COG0625	glutathione transferase activity
ISN32_13890	COG0039	L-malate dehydrogenase activity
ISN32_13900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN32_13905	COG1217	gtp-binding protein TYPA
ISN32_13920	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN32_13930	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN32_13935	COG0203	ribosomal protein L17
ISN32_13960	COG0201	protein transport
ISN32_13970	COG1841	ribosomal large subunit assembly
ISN32_13995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISN32_14000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN32_14005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN32_14015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN32_14020	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN32_14045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN32_14050	COG0089	rRNA binding
ISN32_14055	COG0088	Forms part of the polypeptide exit tunnel
ISN32_14065	COG0051	transcription antitermination factor activity, RNA binding
ISN32_14070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN32_14075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN32_14090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN32_14100	COG0222	ribosome binding
ISN32_14115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN32_14120	COG0250	Participates in transcription elongation, termination and antitermination
ISN32_14125	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN32_14135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN32_14155	COG0012	GTP binding
ISN32_14160	COG0193	aminoacyl-tRNA hydrolase activity
ISN32_14170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN32_14180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN32_14195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN32_14200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN32_14255	COG0488	(ABC) transporter
ISN32_14325	COG3634	alkyl hydroperoxide reductase activity
ISN32_14330	COG0583	DNA-binding transcription factor activity
ISN32_14345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN32_14375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN32_14380	COG0697	spore germination
ISN32_14420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN32_14425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN32_14435	COG2096	Adenosyltransferase
ISN32_14445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN32_14450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN32_14455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN32_14460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN32_14465	COG2967	ApaG domain
ISN32_14470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN32_14505	COG1704	LemA family
ISN32_14510	COG0861	Integral membrane protein TerC family
ISN32_14515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN32_14525	COG0642	Histidine kinase
ISN32_14540	COG4181	ATPase activity
ISN32_14545	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN32_14565	COG4771	TonB-dependent receptor
ISN32_14575	COG0667	Aldo Keto reductase
ISN32_14580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN32_14600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN32_14620	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN32_14685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN32_14695	COG0494	nUDIX hydrolase
ISN32_14710	COG0739	heme binding
ISN32_14720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN32_14725	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN32_14735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN32_14740	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN32_14765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN32_14780	COG3116	cell division
ISN32_14785	COG0275	rRNA processing
ISN32_14790	COG2001	Belongs to the MraZ family
ISN32_14825	COG0792	nuclease activity
ISN32_14835	COG0277	FAD linked oxidase domain protein
ISN32_14840	COG0745	RESPONSE REGULATOR receiver
ISN32_14845	COG2205	protein histidine kinase activity
ISN32_14855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN32_14860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN32_14880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN32_14885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN32_14890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN32_14905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN32_14905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN32_14915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN32_14935	COG0488	(ABC) transporter
ISN32_14940	COG0242	peptide deformylase activity
ISN32_14955	COG1960	acyl-CoA dehydrogenase activity
ISN32_14965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN32_14975	COG1696	Membrane protein involved in D-alanine export
ISN32_14995	COG1215	transferase activity, transferring glycosyl groups
ISN32_15005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN32_15055	COG2188	Transcriptional regulator
ISN32_15065	COG1450	Type ii and iii secretion system protein
ISN32_15080	COG3166	PFAM Fimbrial assembly family protein
ISN32_15085	COG3156	type II secretion system protein K
ISN32_15090	COG4795	General secretion pathway protein
ISN32_15095	COG2165	general secretion pathway protein
ISN32_15100	COG4970	Tfp pilus assembly protein FimT
ISN32_15105	COG2165	general secretion pathway protein
ISN32_15110	COG1459	type II secretion system
ISN32_15115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN32_15120	COG1404	Belongs to the peptidase S8 family
ISN32_15125	COG5295	Hep Hag repeat protein
ISN32_15135	COG0840	transmembrane signaling receptor activity
ISN32_15140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN32_15140	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN32_15145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN32_15150	COG4974	Belongs to the 'phage' integrase family
ISN32_15175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN32_15180	COG2927	DNA polymerase III (CHI subunit)
ISN32_15215	COG1183	phosphatidylcholine synthase activity
ISN32_15225	COG0442	prolyl-tRNA aminoacylation
ISN32_15240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN32_15245	COG1127	ABC transporter
ISN32_15250	COG3218	ABC-type transport auxiliary lipoprotein component
ISN32_15250	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN32_15280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN32_15285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN32_15290	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN32_15290	COG0662	Cupin 2, conserved barrel domain protein
ISN32_15315	COG2086	electron transfer activity
ISN32_15330	COG0546	phosphoglycolate phosphatase activity
ISN32_15330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN32_15335	COG0277	FAD linked oxidase domain protein
ISN32_15340	COG0300	oxidoreductase activity
ISN32_15345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_15360	COG0493	'glutamate synthase
ISN32_15395	COG0438	transferase activity, transferring glycosyl groups
ISN32_15395	COG1216	Glycosyl transferase, family 2
ISN32_15400	COG0438	transferase activity, transferring glycosyl groups
ISN32_15400	COG1216	Glycosyl transferase, family 2
ISN32_15405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN32_15420	COG0626	cystathionine gamma-synthase activity
ISN32_15450	COG0625	glutathione transferase activity
ISN32_15460	COG0513	Belongs to the DEAD box helicase family
ISN32_15465	COG0720	synthase
ISN32_15475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN32_15480	COG1956	GAF domain-containing protein
ISN32_15490	COG4206	TonB-dependent receptor
ISN32_15500	COG0546	phosphoglycolate phosphatase activity
ISN32_15525	COG0339	signal peptide processing
ISN32_15530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISN32_15540	COG2217	Heavy metal translocating P-type atpase
ISN32_15555	COG2132	Multicopper oxidase
ISN32_15570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN32_15580	COG1136	(ABC) transporter
ISN32_15585	COG1136	(ABC) transporter
ISN32_15585	COG0577	efflux transmembrane transporter activity
ISN32_15590	COG0577	efflux transmembrane transporter activity
ISN32_15590	COG1136	(ABC) transporter
ISN32_15615	COG4191	Histidine kinase
ISN32_15625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN32_15640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN32_15655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN32_15665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN32_15675	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN32_15690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN32_15695	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN32_15730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN32_15735	COG0697	spore germination
ISN32_15740	COG1666	GTP binding
ISN32_15750	COG1187	pseudouridine synthase activity
ISN32_15775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN32_15775	COG2205	protein histidine kinase activity
ISN32_15800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN32_15865	COG0842	Transport permease protein
ISN32_15870	COG1131	(ABC) transporter
ISN32_15875	COG0025	NhaP-type Na H and K H
ISN32_15885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN32_15890	COG1573	uracil-dna glycosylase
ISN32_15900	COG3384	dioxygenase
ISN32_15920	COG0667	Aldo Keto reductase
ISN32_15930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_15935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_15960	COG2146	nitrite reductase [NAD(P)H] activity
ISN32_15965	COG5001	Diguanylate cyclase
ISN32_15965	COG3300	MHYT domain
ISN32_15995	COG4106	trans-aconitate 2-methyltransferase activity
ISN32_16005	COG2076	Multidrug Resistance protein
ISN32_16040	COG3275	phosphorelay sensor kinase activity
ISN32_16045	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN32_16065	COG0531	amino acid
ISN32_16075	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_16075	COG5297	Belongs to the glycosyl hydrolase family 6
ISN32_16090	COG0741	lytic transglycosylase activity
ISN32_16105	COG2207	Transcriptional regulator
ISN32_16115	COG0598	Magnesium transport protein CorA
ISN32_16120	COG1113	amino acid transport
ISN32_16125	COG0697	spore germination
ISN32_16150	COG2267	carboxylic ester hydrolase activity
ISN32_16230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN32_16255	COG2353	YceI-like domain
ISN32_16280	COG0584	glycerophosphoryl diester phosphodiesterase
ISN32_16285	COG3547	Transposase (IS116 IS110 IS902 family)
ISN32_16300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN32_16325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN32_16330	COG0459	protein refolding
ISN32_16340	COG1324	tolerance protein
ISN32_16350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN32_16360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN32_16365	COG0511	ligase activity, forming carbon-carbon bonds
ISN32_16370	COG0439	Biotin carboxylase
ISN32_16385	COG2264	protein methyltransferase activity
ISN32_16405	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN32_16410	COG4589	Belongs to the CDS family
ISN32_16430	COG2267	carboxylic ester hydrolase activity
ISN32_16435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN32_16440	COG0138	bifunctional purine biosynthesis protein purh
ISN32_16445	COG0151	Belongs to the GarS family
ISN32_16450	COG1289	transmembrane transporter activity
ISN32_16455	COG2814	Major facilitator Superfamily
ISN32_16495	COG2816	NAD+ diphosphatase activity
ISN32_16540	COG2906	2 iron, 2 sulfur cluster binding
ISN32_16545	COG1051	belongs to the nudix hydrolase family
ISN32_16570	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN32_16585	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN32_16590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN32_16595	COG0730	response to heat
ISN32_16605	COG0134	indole-3-glycerol-phosphate synthase activity
ISN32_16610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN32_16635	COG1597	lipid kinase activity
ISN32_16650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN32_16665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_16670	COG2111	Na H antiporter
ISN32_16670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN32_16675	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN32_16680	COG0651	ATP synthesis coupled electron transport
ISN32_16685	COG1863	multisubunit Na H antiporter MnhE subunit
ISN32_16690	COG2212	antiporter activity
ISN32_16695	COG1320	monovalent cation:proton antiporter activity
ISN32_16700	COG0530	calcium, potassium:sodium antiporter activity
ISN32_16745	COG0625	glutathione transferase activity
ISN32_16765	COG4555	ABC transporter
ISN32_16775	COG1476	TRANSCRIPTIONal
ISN32_16785	COG0543	2 iron, 2 sulfur cluster binding
ISN32_16785	COG0633	Ferredoxin
ISN32_16790	COG1131	(ABC) transporter
ISN32_16795	COG0842	Transport permease protein
ISN32_16835	COG0084	hydrolase, TatD family'
ISN32_16840	COG1643	Atp-dependent helicase
ISN32_16855	COG1187	pseudouridine synthase activity
ISN32_16870	COG2130	NADP-dependent
ISN32_16875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN32_16905	COG0659	secondary active sulfate transmembrane transporter activity
ISN32_16940	COG2224	Isocitrate lyase
ISN32_16945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN32_16950	COG0583	DNA-binding transcription factor activity
ISN32_16970	COG0339	signal peptide processing
ISN32_16990	COG0564	pseudouridine synthase activity
ISN32_16995	COG4232	protein-disulfide reductase activity
ISN32_17010	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN32_17020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN32_17035	COG0318	PFAM AMP-dependent synthetase and ligase
ISN32_17040	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN32_17050	COG0596	Alpha beta hydrolase
ISN32_17065	COG3177	Filamentation induced by cAMP protein fic
ISN32_17070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN32_17080	COG0612	Peptidase, M16
ISN32_17090	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN32_17100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN32_17105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN32_17145	COG0183	Belongs to the thiolase family
ISN32_17155	COG2032	superoxide dismutase activity
ISN32_17160	COG2032	superoxide dismutase activity
ISN32_17165	COG2204	response regulator
ISN32_17170	COG3852	Histidine kinase
ISN32_17175	COG0004	ammonium transporteR
ISN32_17180	COG0347	Belongs to the P(II) protein family
ISN32_17185	COG0174	glutamine synthetase
ISN32_17190	COG1968	undecaprenyl-diphosphatase activity
ISN32_17195	COG1881	PFAM PEBP family protein
ISN32_17205	COG2267	carboxylic ester hydrolase activity
ISN32_17215	COG2050	protein possibly involved in aromatic compounds catabolism
ISN32_17220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN32_17230	COG2062	phosphohistidine phosphatase, SixA
ISN32_17275	COG2271	Major facilitator Superfamily
ISN32_17305	COG1205	dead DEAH box helicase
ISN32_17305	COG1111	helicase
ISN32_17350	COG0069	glutamate synthase activity
ISN32_17350	COG0067	glutamate synthase
ISN32_17350	COG0070	glutamate synthase
ISN32_17355	COG0493	'glutamate synthase
ISN32_17360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_17365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_17370	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN32_17430	COG2951	lytic endotransglycosylase activity
ISN32_17445	COG0730	response to heat
ISN32_17470	COG0302	gtp cyclohydrolase
ISN32_17475	COG0477	Major facilitator Superfamily
ISN32_17525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISN32_17535	COG1074	ATP-dependent DNA helicase activity
ISN32_17540	COG0537	adenosine 5'-monophosphoramidase activity
ISN32_17560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN32_17565	COG1074	ATP-dependent DNA helicase activity
ISN32_17570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN32_17575	COG1127	ABC transporter
ISN32_17580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN32_17585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN32_17600	COG2853	Lipoprotein
ISN32_17605	COG0386	Belongs to the glutathione peroxidase family
ISN32_17610	COG1322	Protein conserved in bacteria
ISN32_17630	COG4191	Histidine kinase
ISN32_17635	COG4566	intracellular signal transduction
ISN32_17640	COG0531	amino acid
ISN32_17650	COG1929	Belongs to the glycerate kinase type-1 family
ISN32_17685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN32_17700	COG0671	phosphoesterase, PA-phosphatase related
ISN32_17715	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN32_17750	COG1522	sequence-specific DNA binding
ISN32_17755	COG3186	Phenylalanine-4-hydroxylase
ISN32_17770	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_17775	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISN32_17785	COG1609	Transcriptional regulator
ISN32_17790	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN32_17805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN32_17850	COG4771	TonB-dependent receptor
ISN32_17870	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN32_17920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN32_17940	COG2186	Transcriptional regulator
ISN32_17945	COG1304	FMN binding
ISN32_17985	COG1012	belongs to the aldehyde dehydrogenase family
ISN32_17990	COG3284	Transcriptional regulator
ISN32_18000	COG4772	TonB-dependent receptor
ISN32_18015	COG1280	lysine exporter protein (LysE YggA)
ISN32_18030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN32_18040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISN32_18070	COG0501	Belongs to the peptidase M48B family
ISN32_18075	COG1266	CAAX protease self-immunity
ISN32_18080	COG0187	DNA topoisomerase II activity
ISN32_18085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN32_18090	COG0592	DNA-directed DNA polymerase activity
ISN32_18105	COG0594	ribonuclease P activity
ISN32_18110	COG0706	membrane insertase activity
ISN32_18125	COG1119	ATPase activity
ISN32_18140	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN32_18155	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN32_18165	COG1435	thymidine kinase activity
ISN32_18170	COG0210	DNA helicase
ISN32_18190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN32_18195	COG0519	Catalyzes the synthesis of GMP from XMP
ISN32_18195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN32_18205	COG0805	protein transport
ISN32_18215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN32_18225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN32_18245	COG0037	tRNA processing
ISN32_18250	COG2115	Belongs to the xylose isomerase family
ISN32_18260	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN32_18270	COG4948	Mandelate Racemase Muconate Lactonizing
ISN32_18280	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN32_18285	COG0246	Mannitol dehydrogenase
ISN32_18300	COG3386	PFAM SMP-30 Gluconolaconase
ISN32_18315	COG1904	glucuronate isomerase
ISN32_18320	COG3693	PFAM glycoside hydrolase, family 10
ISN32_18335	COG2211	Major facilitator Superfamily
ISN32_18360	COG2937	Belongs to the GPAT DAPAT family
ISN32_18370	COG1609	Transcriptional regulator
ISN32_18385	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN32_18450	COG3132	Protein of unknown function, DUF480
ISN32_18470	COG0729	surface antigen
ISN32_18475	COG2911	Protein conserved in bacteria
ISN32_18490	COG3265	gluconokinase activity
ISN32_18495	COG2211	Major facilitator Superfamily
ISN32_18500	COG3459	Glycosyltransferase 36 associated
ISN32_18505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN32_18515	COG2205	protein histidine kinase activity
ISN32_18520	COG1971	Probably functions as a manganese efflux pump
ISN32_18540	COG0477	Major facilitator Superfamily
ISN32_18565	COG2091	lysine biosynthetic process via aminoadipic acid
ISN32_18575	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN32_18580	COG1192	Involved in chromosome partitioning
ISN32_18585	COG1475	DNA binding
ISN32_18595	COG0463	Glycosyl transferase, family 2
ISN32_18645	COG0210	DNA helicase
ISN32_18670	COG0589	response to stress
ISN32_18685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_18685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN32_18690	COG2323	membrane
ISN32_18700	COG0408	coproporphyrinogen oxidase activity
ISN32_18720	COG1271	oxidase subunit
ISN32_18725	COG1294	oxidase, subunit
ISN32_18750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN32_18765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN32_18800	COG0463	Glycosyl transferase, family 2
ISN32_18810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN32_18815	COG3100	YcgL domain-containing protein
ISN32_18825	COG1404	Belongs to the peptidase S8 family
ISN32_18840	COG0745	RESPONSE REGULATOR receiver
ISN32_18845	COG3387	PFAM Glycoside hydrolase 15-related
ISN32_18850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN32_18865	COG1278	Cold shock
ISN32_18885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN32_18890	COG1960	acyl-CoA dehydrogenase activity
ISN32_18900	COG3245	cytochrome
ISN32_18910	COG1742	UPF0060 membrane protein
ISN32_18920	COG0523	cobalamin synthesis protein
ISN32_18925	COG0697	spore germination
ISN32_18935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN32_18940	COG1846	Transcriptional regulator
ISN32_18945	COG1764	response to oxidative stress
ISN32_18955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN32_18960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN32_18985	COG0583	DNA-binding transcription factor activity
ISN32_18990	COG2814	Major facilitator Superfamily
ISN32_19000	COG1902	pentaerythritol trinitrate reductase activity
ISN32_19005	COG2084	Dehydrogenase
ISN32_19030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN32_19060	COG3228	Belongs to the MtfA family
ISN32_19070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN32_19070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN32_19075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN32_19110	COG0180	Tryptophanyl-tRNA synthetase
ISN32_19125	COG0697	spore germination
ISN32_19145	COG0577	efflux transmembrane transporter activity
ISN32_19150	COG1136	(ABC) transporter
ISN32_19175	COG0753	catalase activity
ISN32_19180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN32_19185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN32_19210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN32_19295	COG1506	peptidase
ISN32_19295	COG0823	Involved in the tonB-independent uptake of proteins
ISN32_19310	COG4773	Receptor
ISN32_19330	COG4807	Protein conserved in bacteria
ISN32_19345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN32_19375	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_19380	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN32_19385	COG4948	Mandelate Racemase Muconate Lactonizing
ISN32_19390	COG3254	rhamnose metabolic process
ISN32_19395	COG0738	Major facilitator superfamily
ISN32_19400	COG1414	Transcriptional regulator
ISN32_19445	COG1802	Transcriptional regulator
ISN32_19450	COG0477	Major facilitator Superfamily
ISN32_19465	COG1595	DNA-templated transcription, initiation
ISN32_19485	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_19485	COG0604	alcohol dehydrogenase
ISN32_19485	COG3321	synthase
ISN32_19495	COG3264	Mechanosensitive ion channel
ISN32_19495	COG1196	nuclear chromosome segregation
ISN32_19515	COG2354	Protein conserved in bacteria
ISN32_19545	COG0513	Belongs to the DEAD box helicase family
ISN32_19560	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN32_19575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN32_19600	COG3104	oligopeptide transport
ISN32_19625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN32_19685	COG1199	ATP-dependent helicase activity
ISN32_19750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN32_19770	COG0628	permease
ISN32_19780	COG2133	pyrroloquinoline quinone binding
ISN32_19825	COG0754	glutathionylspermidine amidase activity
ISN32_19835	COG0714	Associated with various cellular activities
ISN32_19880	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN32_19895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN32_19900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN32_19910	COG2203	Gaf domain
ISN32_19910	COG3706	GGDEF domain
ISN32_19910	COG4251	negative regulation of phosphorylation
ISN32_19910	COG5001	Diguanylate cyclase
ISN32_19925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN32_19945	COG1028	Short-chain dehydrogenase reductase Sdr
ISN32_19960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN32_19970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN32_20005	COG0606	chelatase, subunit chli
ISN32_20010	COG2960	long-chain fatty acid transporting porin activity
ISN32_20025	COG1166	arginine decarboxylase activity
ISN32_20030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN32_20035	COG1819	glycosyl
ISN32_20040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN32_20040	COG2755	lipolytic protein G-D-S-L family
ISN32_20045	COG0583	DNA-binding transcription factor activity
ISN32_20065	COG4221	oxidoreductase activity
ISN32_20085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN32_20105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN32_20115	COG2814	Major facilitator Superfamily
ISN32_20125	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN32_20130	COG0739	heme binding
ISN32_20135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)