locus-tag	class	description
ISN34_00030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN34_00035	COG0739	heme binding
ISN34_00040	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN34_00050	COG2814	Major facilitator Superfamily
ISN34_00060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN34_00080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN34_00100	COG4221	oxidoreductase activity
ISN34_00120	COG0583	DNA-binding transcription factor activity
ISN34_00125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN34_00125	COG2755	lipolytic protein G-D-S-L family
ISN34_00130	COG1819	glycosyl
ISN34_00135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN34_00140	COG1166	arginine decarboxylase activity
ISN34_00155	COG2960	long-chain fatty acid transporting porin activity
ISN34_00160	COG0606	chelatase, subunit chli
ISN34_00175	COG2267	carboxylic ester hydrolase activity
ISN34_00205	COG0076	glutamate decarboxylase activity
ISN34_00210	COG0457	Tetratricopeptide repeat
ISN34_00235	COG2224	Isocitrate lyase
ISN34_00255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN34_00265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN34_00270	COG0156	8-amino-7-oxononanoate synthase activity
ISN34_00300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN34_00315	COG5001	Diguanylate cyclase
ISN34_00315	COG4251	negative regulation of phosphorylation
ISN34_00315	COG3706	GGDEF domain
ISN34_00315	COG2203	Gaf domain
ISN34_00325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN34_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN34_00345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN34_00360	COG1522	sequence-specific DNA binding
ISN34_00395	COG0714	Associated with various cellular activities
ISN34_00405	COG0754	glutathionylspermidine amidase activity
ISN34_00435	COG2133	pyrroloquinoline quinone binding
ISN34_00465	COG2963	transposase activity
ISN34_00475	COG0628	permease
ISN34_00520	COG1199	ATP-dependent helicase activity
ISN34_00590	COG0625	glutathione transferase activity
ISN34_00610	COG4555	ABC transporter
ISN34_00620	COG1476	TRANSCRIPTIONal
ISN34_00630	COG0633	Ferredoxin
ISN34_00630	COG0543	2 iron, 2 sulfur cluster binding
ISN34_00635	COG1131	(ABC) transporter
ISN34_00640	COG0842	Transport permease protein
ISN34_00730	COG0084	hydrolase, TatD family'
ISN34_00735	COG1643	Atp-dependent helicase
ISN34_00745	COG1187	pseudouridine synthase activity
ISN34_00760	COG2130	NADP-dependent
ISN34_00765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN34_00795	COG0659	secondary active sulfate transmembrane transporter activity
ISN34_00830	COG2224	Isocitrate lyase
ISN34_00835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN34_00840	COG0583	DNA-binding transcription factor activity
ISN34_00860	COG0339	signal peptide processing
ISN34_00880	COG0564	pseudouridine synthase activity
ISN34_00885	COG4232	protein-disulfide reductase activity
ISN34_00900	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN34_00910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN34_00925	COG0318	PFAM AMP-dependent synthetase and ligase
ISN34_00930	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN34_00940	COG0596	Alpha beta hydrolase
ISN34_00955	COG3177	Filamentation induced by cAMP protein fic
ISN34_00960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN34_00970	COG0612	Peptidase, M16
ISN34_00980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN34_00990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN34_00995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN34_01035	COG0183	Belongs to the thiolase family
ISN34_01045	COG2032	superoxide dismutase activity
ISN34_01050	COG2032	superoxide dismutase activity
ISN34_01055	COG2204	response regulator
ISN34_01060	COG3852	Histidine kinase
ISN34_01065	COG0004	ammonium transporteR
ISN34_01070	COG0347	Belongs to the P(II) protein family
ISN34_01075	COG0174	glutamine synthetase
ISN34_01080	COG1968	undecaprenyl-diphosphatase activity
ISN34_01085	COG1881	PFAM PEBP family protein
ISN34_01095	COG2267	carboxylic ester hydrolase activity
ISN34_01105	COG2050	protein possibly involved in aromatic compounds catabolism
ISN34_01110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN34_01120	COG2062	phosphohistidine phosphatase, SixA
ISN34_01165	COG2271	Major facilitator Superfamily
ISN34_01195	COG1205	dead DEAH box helicase
ISN34_01195	COG1111	helicase
ISN34_01240	COG0069	glutamate synthase activity
ISN34_01240	COG0067	glutamate synthase
ISN34_01240	COG0070	glutamate synthase
ISN34_01245	COG0493	'glutamate synthase
ISN34_01250	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN34_01255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN34_01260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN34_01320	COG2951	lytic endotransglycosylase activity
ISN34_01340	COG0730	response to heat
ISN34_01365	COG0302	gtp cyclohydrolase
ISN34_01370	COG0477	Major facilitator Superfamily
ISN34_01420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISN34_01430	COG1074	ATP-dependent DNA helicase activity
ISN34_01435	COG0537	adenosine 5'-monophosphoramidase activity
ISN34_01455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN34_01460	COG1074	ATP-dependent DNA helicase activity
ISN34_01465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN34_01470	COG1127	ABC transporter
ISN34_01475	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN34_01480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN34_01495	COG2853	Lipoprotein
ISN34_01505	COG0386	Belongs to the glutathione peroxidase family
ISN34_01510	COG1322	Protein conserved in bacteria
ISN34_01530	COG4191	Histidine kinase
ISN34_01535	COG4566	intracellular signal transduction
ISN34_01540	COG0531	amino acid
ISN34_01550	COG1929	Belongs to the glycerate kinase type-1 family
ISN34_01585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN34_01600	COG0671	phosphoesterase, PA-phosphatase related
ISN34_01615	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN34_01655	COG1522	sequence-specific DNA binding
ISN34_01660	COG3186	Phenylalanine-4-hydroxylase
ISN34_01675	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_01680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ISN34_01690	COG1609	Transcriptional regulator
ISN34_01695	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN34_01710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN34_01760	COG4771	TonB-dependent receptor
ISN34_01780	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN34_01835	COG0246	Mannitol dehydrogenase
ISN34_01840	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN34_01850	COG4948	Mandelate Racemase Muconate Lactonizing
ISN34_01860	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN34_01875	COG0037	tRNA processing
ISN34_01895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN34_01905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN34_01915	COG0805	protein transport
ISN34_01925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN34_01925	COG0519	Catalyzes the synthesis of GMP from XMP
ISN34_01930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN34_01950	COG0210	DNA helicase
ISN34_01955	COG1435	thymidine kinase activity
ISN34_01965	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN34_01980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN34_01995	COG1119	ATPase activity
ISN34_02005	COG0706	membrane insertase activity
ISN34_02010	COG0594	ribonuclease P activity
ISN34_02025	COG0592	DNA-directed DNA polymerase activity
ISN34_02030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN34_02035	COG0187	DNA topoisomerase II activity
ISN34_02040	COG1266	CAAX protease self-immunity
ISN34_02045	COG0501	Belongs to the peptidase M48B family
ISN34_02075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISN34_02085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN34_02100	COG1280	lysine exporter protein (LysE YggA)
ISN34_02115	COG4772	TonB-dependent receptor
ISN34_02125	COG3284	Transcriptional regulator
ISN34_02130	COG1012	belongs to the aldehyde dehydrogenase family
ISN34_02165	COG1304	FMN binding
ISN34_02170	COG2186	Transcriptional regulator
ISN34_02190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN34_02240	COG3386	PFAM SMP-30 Gluconolaconase
ISN34_02255	COG1904	glucuronate isomerase
ISN34_02260	COG3693	PFAM glycoside hydrolase, family 10
ISN34_02275	COG2211	Major facilitator Superfamily
ISN34_02300	COG2937	Belongs to the GPAT DAPAT family
ISN34_02310	COG1609	Transcriptional regulator
ISN34_02325	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN34_02355	COG3132	Protein of unknown function, DUF480
ISN34_02375	COG0729	surface antigen
ISN34_02380	COG2911	Protein conserved in bacteria
ISN34_02400	COG2211	Major facilitator Superfamily
ISN34_02405	COG3459	Glycosyltransferase 36 associated
ISN34_02410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN34_02420	COG2205	protein histidine kinase activity
ISN34_02425	COG1971	Probably functions as a manganese efflux pump
ISN34_02445	COG0477	Major facilitator Superfamily
ISN34_02470	COG2091	lysine biosynthetic process via aminoadipic acid
ISN34_02480	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN34_02485	COG1192	Involved in chromosome partitioning
ISN34_02490	COG1475	DNA binding
ISN34_02500	COG0463	Glycosyl transferase, family 2
ISN34_02550	COG0210	DNA helicase
ISN34_02575	COG0589	response to stress
ISN34_02590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN34_02590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN34_02595	COG2323	membrane
ISN34_02605	COG0408	coproporphyrinogen oxidase activity
ISN34_02625	COG1271	oxidase subunit
ISN34_02630	COG1294	oxidase, subunit
ISN34_02655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN34_02670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN34_02705	COG0463	Glycosyl transferase, family 2
ISN34_02715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN34_02720	COG3100	YcgL domain-containing protein
ISN34_02745	COG0745	RESPONSE REGULATOR receiver
ISN34_02750	COG3387	PFAM Glycoside hydrolase 15-related
ISN34_02755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN34_02770	COG1278	Cold shock
ISN34_02790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN34_02795	COG1960	acyl-CoA dehydrogenase activity
ISN34_02805	COG3245	cytochrome
ISN34_02815	COG1742	UPF0060 membrane protein
ISN34_02825	COG0523	cobalamin synthesis protein
ISN34_02830	COG0697	spore germination
ISN34_02840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN34_02845	COG1846	Transcriptional regulator
ISN34_02850	COG1764	response to oxidative stress
ISN34_02860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN34_02865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN34_02880	COG0583	DNA-binding transcription factor activity
ISN34_02885	COG2814	Major facilitator Superfamily
ISN34_02895	COG1902	pentaerythritol trinitrate reductase activity
ISN34_02900	COG2084	Dehydrogenase
ISN34_02925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN34_02955	COG3228	Belongs to the MtfA family
ISN34_02965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN34_02965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN34_02970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN34_03005	COG0180	Tryptophanyl-tRNA synthetase
ISN34_03020	COG0697	spore germination
ISN34_03040	COG0577	efflux transmembrane transporter activity
ISN34_03045	COG1136	(ABC) transporter
ISN34_03070	COG0753	catalase activity
ISN34_03075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN34_03080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN34_03105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN34_03190	COG1506	peptidase
ISN34_03190	COG0823	Involved in the tonB-independent uptake of proteins
ISN34_03205	COG4773	Receptor
ISN34_03225	COG4807	Protein conserved in bacteria
ISN34_03240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN34_03275	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_03280	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN34_03285	COG4948	Mandelate Racemase Muconate Lactonizing
ISN34_03290	COG3254	rhamnose metabolic process
ISN34_03295	COG0738	Major facilitator superfamily
ISN34_03300	COG1414	Transcriptional regulator
ISN34_03330	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ISN34_03345	COG1802	Transcriptional regulator
ISN34_03360	COG1595	DNA-templated transcription, initiation
ISN34_03380	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_03380	COG3321	synthase
ISN34_03380	COG0604	alcohol dehydrogenase
ISN34_03385	COG3264	Mechanosensitive ion channel
ISN34_03385	COG1196	nuclear chromosome segregation
ISN34_03405	COG2354	Protein conserved in bacteria
ISN34_03435	COG0513	Belongs to the DEAD box helicase family
ISN34_03455	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN34_03470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN34_03485	COG3483	tryptophan 2,3-dioxygenase activity
ISN34_03490	COG3104	oligopeptide transport
ISN34_03510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN34_03530	COG0530	calcium, potassium:sodium antiporter activity
ISN34_03535	COG1320	monovalent cation:proton antiporter activity
ISN34_03540	COG2212	antiporter activity
ISN34_03545	COG1863	multisubunit Na H antiporter MnhE subunit
ISN34_03550	COG0651	ATP synthesis coupled electron transport
ISN34_03555	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN34_03560	COG2111	Na H antiporter
ISN34_03560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN34_03565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN34_03580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN34_03595	COG1597	lipid kinase activity
ISN34_03615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN34_03620	COG0134	indole-3-glycerol-phosphate synthase activity
ISN34_03630	COG0730	response to heat
ISN34_03635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN34_03640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN34_03655	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN34_03680	COG1051	belongs to the nudix hydrolase family
ISN34_03685	COG2906	2 iron, 2 sulfur cluster binding
ISN34_03725	COG2816	NAD+ diphosphatase activity
ISN34_03765	COG2814	Major facilitator Superfamily
ISN34_03770	COG1289	transmembrane transporter activity
ISN34_03775	COG0151	Belongs to the GarS family
ISN34_03780	COG0138	bifunctional purine biosynthesis protein purh
ISN34_03785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN34_03790	COG2267	carboxylic ester hydrolase activity
ISN34_03810	COG4589	Belongs to the CDS family
ISN34_03815	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN34_03835	COG2264	protein methyltransferase activity
ISN34_03850	COG0439	Biotin carboxylase
ISN34_03855	COG0511	ligase activity, forming carbon-carbon bonds
ISN34_03860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN34_03870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN34_03875	COG4232	protein-disulfide reductase activity
ISN34_03880	COG1324	tolerance protein
ISN34_03895	COG0459	protein refolding
ISN34_03900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN34_03920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN34_03935	COG0584	glycerophosphoryl diester phosphodiesterase
ISN34_03965	COG2353	YceI-like domain
ISN34_03980	COG0840	transmembrane signaling receptor activity
ISN34_04110	COG2267	carboxylic ester hydrolase activity
ISN34_04135	COG0697	spore germination
ISN34_04140	COG1113	amino acid transport
ISN34_04145	COG0598	Magnesium transport protein CorA
ISN34_04155	COG2207	Transcriptional regulator
ISN34_04175	COG0741	lytic transglycosylase activity
ISN34_04190	COG5297	Belongs to the glycosyl hydrolase family 6
ISN34_04190	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN34_04200	COG0531	amino acid
ISN34_04220	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN34_04225	COG3275	phosphorelay sensor kinase activity
ISN34_04250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN34_04260	COG2076	Multidrug Resistance protein
ISN34_04270	COG4106	trans-aconitate 2-methyltransferase activity
ISN34_04300	COG5001	Diguanylate cyclase
ISN34_04310	COG3706	GGDEF domain
ISN34_04330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN34_04335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN34_04345	COG0667	Aldo Keto reductase
ISN34_04365	COG3384	dioxygenase
ISN34_04375	COG1573	uracil-dna glycosylase
ISN34_04380	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN34_04390	COG0025	NhaP-type Na H and K H
ISN34_04395	COG1131	(ABC) transporter
ISN34_04400	COG0842	Transport permease protein
ISN34_04460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN34_04485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN34_04485	COG2205	protein histidine kinase activity
ISN34_04510	COG1187	pseudouridine synthase activity
ISN34_04520	COG1666	GTP binding
ISN34_04525	COG0697	spore germination
ISN34_04530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN34_04565	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN34_04570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN34_04585	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN34_04595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN34_04605	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN34_04620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN34_04635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN34_04645	COG4191	Histidine kinase
ISN34_04655	COG0577	efflux transmembrane transporter activity
ISN34_04655	COG1136	(ABC) transporter
ISN34_04660	COG0577	efflux transmembrane transporter activity
ISN34_04660	COG1136	(ABC) transporter
ISN34_04665	COG1136	(ABC) transporter
ISN34_04675	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN34_04695	COG2132	Multicopper oxidase
ISN34_04710	COG2217	Heavy metal translocating P-type atpase
ISN34_04725	COG0339	signal peptide processing
ISN34_04750	COG0546	phosphoglycolate phosphatase activity
ISN34_04760	COG4206	TonB-dependent receptor
ISN34_04770	COG1956	GAF domain-containing protein
ISN34_04775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN34_04785	COG0720	synthase
ISN34_04790	COG0513	Belongs to the DEAD box helicase family
ISN34_04800	COG0625	glutathione transferase activity
ISN34_04830	COG0626	cystathionine gamma-synthase activity
ISN34_04845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN34_04850	COG1216	Glycosyl transferase, family 2
ISN34_04850	COG0438	transferase activity, transferring glycosyl groups
ISN34_04855	COG0438	transferase activity, transferring glycosyl groups
ISN34_04855	COG1216	Glycosyl transferase, family 2
ISN34_04890	COG0493	'glutamate synthase
ISN34_04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN34_04915	COG0300	oxidoreductase activity
ISN34_04920	COG0277	FAD linked oxidase domain protein
ISN34_04925	COG0546	phosphoglycolate phosphatase activity
ISN34_04925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN34_04940	COG2086	electron transfer activity
ISN34_04965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN34_04965	COG0662	Cupin 2, conserved barrel domain protein
ISN34_04970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN34_04975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN34_05005	COG3218	ABC-type transport auxiliary lipoprotein component
ISN34_05005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN34_05010	COG1127	ABC transporter
ISN34_05015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN34_05030	COG0442	prolyl-tRNA aminoacylation
ISN34_05040	COG1183	phosphatidylcholine synthase activity
ISN34_05080	COG2927	DNA polymerase III (CHI subunit)
ISN34_05085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN34_05110	COG4974	Belongs to the 'phage' integrase family
ISN34_05115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN34_05120	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN34_05120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN34_05125	COG0840	transmembrane signaling receptor activity
ISN34_05135	COG5295	Hep Hag repeat protein
ISN34_05140	COG1404	Belongs to the peptidase S8 family
ISN34_05145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN34_05150	COG1459	type II secretion system
ISN34_05155	COG2165	general secretion pathway protein
ISN34_05160	COG4970	Tfp pilus assembly protein FimT
ISN34_05165	COG2165	general secretion pathway protein
ISN34_05170	COG4795	General secretion pathway protein
ISN34_05175	COG3156	type II secretion system protein K
ISN34_05180	COG3166	PFAM Fimbrial assembly family protein
ISN34_05195	COG1450	Type ii and iii secretion system protein
ISN34_05205	COG2188	Transcriptional regulator
ISN34_05260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN34_05270	COG1215	transferase activity, transferring glycosyl groups
ISN34_05290	COG1696	Membrane protein involved in D-alanine export
ISN34_05300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN34_05310	COG1960	acyl-CoA dehydrogenase activity
ISN34_05325	COG0242	peptide deformylase activity
ISN34_05330	COG0488	(ABC) transporter
ISN34_05350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN34_05360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN34_05360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN34_05375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN34_05380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN34_05385	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN34_05410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN34_05415	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN34_05425	COG2205	protein histidine kinase activity
ISN34_05430	COG0745	RESPONSE REGULATOR receiver
ISN34_05435	COG0277	FAD linked oxidase domain protein
ISN34_05440	COG1988	membrane-bound metal-dependent
ISN34_05445	COG0792	nuclease activity
ISN34_05475	COG2001	Belongs to the MraZ family
ISN34_05480	COG0275	rRNA processing
ISN34_05485	COG3116	cell division
ISN34_05500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN34_05525	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN34_05530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN34_05540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN34_05545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN34_05555	COG0739	heme binding
ISN34_05570	COG0494	nUDIX hydrolase
ISN34_05580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN34_05605	COG2226	methyltransferase
ISN34_05645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN34_05670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN34_05690	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN34_05695	COG0667	Aldo Keto reductase
ISN34_05705	COG4771	TonB-dependent receptor
ISN34_05725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN34_05730	COG4181	ATPase activity
ISN34_05745	COG0642	Histidine kinase
ISN34_05755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN34_05760	COG0861	Integral membrane protein TerC family
ISN34_05765	COG1704	LemA family
ISN34_05795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN34_05800	COG2967	ApaG domain
ISN34_05805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN34_05810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN34_05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN34_05820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN34_05835	COG2096	Adenosyltransferase
ISN34_05845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN34_05850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN34_05895	COG0697	spore germination
ISN34_05900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN34_05930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN34_05945	COG0583	DNA-binding transcription factor activity
ISN34_05950	COG3634	alkyl hydroperoxide reductase activity
ISN34_06015	COG0488	(ABC) transporter
ISN34_06065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN34_06070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN34_06085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN34_06095	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN34_06105	COG0193	aminoacyl-tRNA hydrolase activity
ISN34_06110	COG0012	GTP binding
ISN34_06130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN34_06140	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN34_06145	COG0250	Participates in transcription elongation, termination and antitermination
ISN34_06150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN34_06165	COG0222	ribosome binding
ISN34_06175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN34_06190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN34_06195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN34_06200	COG0051	transcription antitermination factor activity, RNA binding
ISN34_06210	COG0088	Forms part of the polypeptide exit tunnel
ISN34_06215	COG0089	rRNA binding
ISN34_06220	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN34_06245	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN34_06250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN34_06260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN34_06265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN34_06270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISN34_06295	COG1841	ribosomal large subunit assembly
ISN34_06305	COG0201	protein transport
ISN34_06330	COG0203	ribosomal protein L17
ISN34_06335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN34_06345	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN34_06360	COG1217	gtp-binding protein TYPA
ISN34_06365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN34_06375	COG0039	L-malate dehydrogenase activity
ISN34_06385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISN34_06390	COG0625	glutathione transferase activity
ISN34_06435	COG1902	pentaerythritol trinitrate reductase activity
ISN34_06435	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN34_06445	COG0667	Aldo Keto reductase
ISN34_06465	COG2885	chlorophyll binding
ISN34_06485	COG0156	8-amino-7-oxononanoate synthase activity
ISN34_06490	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN34_06495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN34_06500	COG4208	sulfate ABC transporter
ISN34_06505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN34_06525	COG0588	phosphoglycerate mutase activity
ISN34_06530	COG0285	dihydrofolate synthase activity
ISN34_06550	COG2833	Protein of unknown function (DUF455)
ISN34_06555	COG3291	Pkd domain containing protein
ISN34_06565	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN34_06575	COG0438	transferase activity, transferring glycosyl groups
ISN34_06585	COG0248	Ppx GppA phosphatase
ISN34_06590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN34_06605	COG4783	chaperone-mediated protein folding
ISN34_06620	COG0473	3-isopropylmalate dehydrogenase activity
ISN34_06670	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN34_06680	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN34_06715	COG1388	LysM domain
ISN34_06715	COG3942	CHAP domain
ISN34_06720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN34_06730	COG0328	RNA-DNA hybrid ribonuclease activity
ISN34_06735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN34_06740	COG0631	protein serine/threonine phosphatase activity
ISN34_06760	COG0859	PFAM glycosyl transferase family 9
ISN34_06770	COG1234	tRNA 3'-trailer cleavage
ISN34_06775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN34_06785	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN34_06790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN34_06795	COG0314	molybdopterin synthase activity
ISN34_06825	COG0537	adenosine 5'-monophosphoramidase activity
ISN34_06845	COG0714	Associated with various cellular activities
ISN34_06870	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN34_06880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN34_06885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN34_06890	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_06895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN34_06905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN34_06910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN34_06915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN34_06935	COG4115	mRNA cleavage
ISN34_06940	COG2161	toxin-antitoxin pair type II binding
ISN34_06965	COG0372	Belongs to the citrate synthase family
ISN34_06980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN34_07035	COG2373	Large extracellular alpha-helical protein
ISN34_07055	COG4953	penicillin-binding protein 1C
ISN34_07065	COG0678	peroxiredoxin activity
ISN34_07085	COG0604	alcohol dehydrogenase
ISN34_07090	COG0330	HflC and HflK could
ISN34_07095	COG0330	HflC and HflK could
ISN34_07105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN34_07215	COG3459	Glycosyltransferase 36 associated
ISN34_07225	COG1063	alcohol dehydrogenase
ISN34_07250	COG0753	catalase activity
ISN34_07265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN34_07265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN34_07290	COG2814	Major facilitator Superfamily
ISN34_07375	COG2194	sulfuric ester hydrolase activity
ISN34_07385	COG0745	RESPONSE REGULATOR receiver
ISN34_07390	COG2205	protein histidine kinase activity
ISN34_07400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN34_07405	COG2894	cell division
ISN34_07410	COG0850	regulation of cytokinetic process
ISN34_07420	COG4585	Histidine kinase
ISN34_07445	COG1216	Glycosyl transferase, family 2
ISN34_07450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN34_07460	COG1199	ATP-dependent helicase activity
ISN34_07480	COG0189	ligase activity
ISN34_07495	COG0835	chemotaxis
ISN34_07500	COG0840	transmembrane signaling receptor activity
ISN34_07505	COG2198	Histidine kinase
ISN34_07505	COG0784	Response regulator, receiver
ISN34_07505	COG0643	Histidine kinase
ISN34_07510	COG2201	protein-glutamate methylesterase activity
ISN34_07555	COG1446	asparaginase
ISN34_07560	COG3142	Participates in the control of copper homeostasis
ISN34_07600	COG0217	transcriptional regulatory protein
ISN34_07610	COG0632	four-way junction helicase activity
ISN34_07615	COG3158	transport of potassium into the cell
ISN34_07620	COG2255	four-way junction helicase activity
ISN34_07625	COG0824	Thioesterase
ISN34_07635	COG0848	biopolymer transport protein
ISN34_07650	COG2885	chlorophyll binding
ISN34_07660	COG0602	queuosine metabolic process
ISN34_07665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN34_07685	COG0514	ATP-dependent DNA helicase (RecQ)
ISN34_07690	COG0783	Belongs to the Dps family
ISN34_07695	COG1643	Atp-dependent helicase
ISN34_07745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN34_07810	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN34_07825	COG1946	Acyl-CoA thioesterase
ISN34_07830	COG1024	Enoyl-CoA hydratase
ISN34_07840	COG0824	Thioesterase
ISN34_07845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN34_07850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN34_07855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN34_07865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISN34_07875	COG0728	peptidoglycan biosynthetic process
ISN34_07895	COG0196	riboflavin kinase activity
ISN34_07910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN34_08005	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ISN34_08005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN34_08055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN34_08060	COG1845	cytochrome c oxidase, subunit III
ISN34_08065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN34_08075	COG0156	8-amino-7-oxononanoate synthase activity
ISN34_08100	COG1595	DNA-templated transcription, initiation
ISN34_08125	COG0745	RESPONSE REGULATOR receiver
ISN34_08155	COG4794	Type iii secretion
ISN34_08180	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN34_08225	COG2207	Transcriptional regulator
ISN34_08255	COG0129	dihydroxy-acid dehydratase activity
ISN34_08275	COG1012	belongs to the aldehyde dehydrogenase family
ISN34_08280	COG1879	ABC-type sugar transport system periplasmic component
ISN34_08285	COG1129	ABC transporter
ISN34_08290	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN34_08295	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN34_08305	COG1082	Xylose isomerase domain protein TIM barrel
ISN34_08310	COG0625	glutathione transferase activity
ISN34_08320	COG0475	glutathione-regulated potassium exporter activity
ISN34_08345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN34_08350	COG2070	2-Nitropropane dioxygenase
ISN34_08360	COG0228	four-way junction DNA binding
ISN34_08365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN34_08370	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN34_08375	COG0335	large ribosomal subunit rRNA binding
ISN34_08380	COG0534	Mate efflux family protein
ISN34_08390	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN34_08410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN34_08425	COG2855	membrane
ISN34_08460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN34_08465	COG0481	GTPase activity
ISN34_08470	COG0681	Belongs to the peptidase S26 family
ISN34_08485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN34_08495	COG0745	RESPONSE REGULATOR receiver
ISN34_08505	COG2954	triphosphatase activity
ISN34_08515	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN34_08520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN34_08525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN34_08530	COG1278	Cold shock
ISN34_08535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN34_08545	COG1201	RNA secondary structure unwinding
ISN34_08550	COG1793	dna ligase
ISN34_08550	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN34_08555	COG1793	dna ligase
ISN34_08555	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN34_08585	COG0443	Heat shock 70 kDa protein
ISN34_08595	COG0183	Belongs to the thiolase family
ISN34_08625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN34_08625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN34_08625	COG1703	isobutyryl-CoA mutase activity
ISN34_08690	COG3250	beta-galactosidase activity
ISN34_08695	COG2186	Transcriptional regulator
ISN34_08705	COG2205	protein histidine kinase activity
ISN34_08705	COG2198	Histidine kinase
ISN34_08705	COG0784	Response regulator, receiver
ISN34_08725	COG1451	nucleotide metabolic process
ISN34_08735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN34_08770	COG1077	Cell shape determining protein MreB Mrl
ISN34_08775	COG1047	Peptidyl-prolyl cis-trans
ISN34_08780	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN34_08785	COG1902	pentaerythritol trinitrate reductase activity
ISN34_08790	COG2814	Major facilitator Superfamily
ISN34_08820	COG0392	lysyltransferase activity
ISN34_08820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN34_08830	COG0251	oxidation-reduction process
ISN34_08855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN34_08880	COG1595	DNA-templated transcription, initiation
ISN34_08895	COG2878	Part of a membrane complex involved in electron transport
ISN34_08915	COG0346	lactoylglutathione lyase activity
ISN34_08925	COG0833	amino acid
ISN34_08930	COG2040	homocysteine
ISN34_08940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN34_08955	COG3118	belongs to the thioredoxin family
ISN34_08965	COG0495	leucyl-tRNA aminoacylation
ISN34_08980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN34_08995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN34_09010	COG2968	Membrane
ISN34_09030	COG0312	modulator of DNA gyrase
ISN34_09040	COG0312	modulator of DNA gyrase
ISN34_09135	COG0631	protein serine/threonine phosphatase activity
ISN34_09140	COG2815	serine threonine protein kinase
ISN34_09140	COG0515	serine threonine protein kinase
ISN34_09165	COG1858	cytochrome C peroxidase
ISN34_09175	COG0142	geranyltranstransferase activity
ISN34_09180	COG1722	exodeoxyribonuclease VII activity
ISN34_09185	COG0037	tRNA processing
ISN34_09195	COG1785	Belongs to the alkaline phosphatase family
ISN34_09200	COG1301	dicarboxylic acid transport
ISN34_09210	COG1607	acyl-coa hydrolase
ISN34_09225	COG0791	NLP P60 protein
ISN34_09230	COG0791	NLP P60 protein
ISN34_09235	COG1047	Peptidyl-prolyl cis-trans
ISN34_09240	COG2311	Membrane
ISN34_09245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN34_09265	COG0697	spore germination
ISN34_09305	COG3590	peptidase
ISN34_09320	COG0457	Tetratricopeptide repeat
ISN34_09325	COG4771	TonB-dependent receptor
ISN34_09335	COG4771	TonB-dependent receptor
ISN34_09345	COG0489	protein tyrosine kinase activity
ISN34_09350	COG0717	Belongs to the dCTP deaminase family
ISN34_09355	COG1714	RDD family
ISN34_09375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN34_09390	COG0494	nUDIX hydrolase
ISN34_09395	COG0433	COG0433 Predicted ATPase
ISN34_09400	COG0741	lytic transglycosylase activity
ISN34_09405	COG0688	phosphatidylethanolamine metabolic process
ISN34_09415	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN34_09475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN34_09505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN34_09515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN34_09520	COG0649	NAD binding
ISN34_09525	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN34_09530	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN34_09570	COG1007	ATP synthesis coupled electron transport
ISN34_09585	COG0195	Participates in both transcription termination and antitermination
ISN34_09610	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN34_09620	COG3300	MHYT domain
ISN34_09620	COG5001	Diguanylate cyclase
ISN34_09645	COG0840	transmembrane signaling receptor activity
ISN34_09650	COG0840	transmembrane signaling receptor activity
ISN34_09655	COG0835	chemotaxis
ISN34_09705	COG1194	a g-specific adenine glycosylase
ISN34_09710	COG0552	protein localization to endoplasmic reticulum
ISN34_09720	COG3938	Belongs to the proline racemase family
ISN34_09725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN34_09740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN34_09750	COG0006	proline dipeptidase activity
ISN34_09765	COG0531	amino acid
ISN34_09800	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN34_09810	COG4771	TonB-dependent receptor
ISN34_09830	COG0326	Molecular chaperone. Has ATPase activity
ISN34_09835	COG0742	ribosomal rna small subunit methyltransferase
ISN34_09850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN34_09855	COG0405	Gamma-glutamyltransferase
ISN34_09860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN34_09865	COG3291	Pkd domain containing protein
ISN34_09870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN34_09880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN34_09890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN34_09900	COG1862	Preprotein translocase
ISN34_09905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN34_09930	COG2203	Gaf domain
ISN34_09930	COG3706	GGDEF domain
ISN34_09930	COG4251	negative regulation of phosphorylation
ISN34_09930	COG5001	Diguanylate cyclase
ISN34_09935	COG1509	lysine 2,3-aminomutase activity
ISN34_09945	COG3548	integral membrane protein
ISN34_09950	COG0402	S-adenosylhomocysteine deaminase activity
ISN34_09980	COG4677	pectinesterase activity
ISN34_09995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN34_10025	COG2166	iron-sulfur cluster assembly
ISN34_10040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN34_10045	COG0137	argininosuccinate synthase activity
ISN34_10050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN34_10055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN34_10065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN34_10070	COG0165	Argininosuccinate lyase
ISN34_10090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN34_10120	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN34_10130	COG1070	Carbohydrate kinase
ISN34_10135	COG2115	Belongs to the xylose isomerase family
ISN34_10140	COG0477	Major facilitator Superfamily
ISN34_10145	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN34_10165	COG0617	tRNA 3'-terminal CCA addition
ISN34_10175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN34_10190	COG0166	Belongs to the GPI family
ISN34_10210	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN34_10225	COG0671	phosphoesterase, PA-phosphatase related
ISN34_10250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN34_10255	COG0167	dihydroorotate dehydrogenase activity
ISN34_10270	COG1012	belongs to the aldehyde dehydrogenase family
ISN34_10285	COG0527	aspartate kinase activity
ISN34_10285	COG0460	homoserine dehydrogenase
ISN34_10295	COG2951	lytic endotransglycosylase activity
ISN34_10305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN34_10315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN34_10320	COG0124	histidyl-tRNA synthetase
ISN34_10330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN34_10335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN34_10340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN34_10350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN34_10365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN34_10365	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN34_10380	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN34_10385	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN34_10395	COG0531	amino acid
ISN34_10400	COG0531	amino acid
ISN34_10415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN34_10420	COG0277	FAD linked oxidase domain protein
ISN34_10440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN34_10455	COG1024	Enoyl-CoA hydratase
ISN34_10505	COG1741	Belongs to the pirin family
ISN34_10510	COG0583	DNA-binding transcription factor activity
ISN34_10530	COG0351	phosphomethylpyrimidine kinase
ISN34_10545	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN34_10550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN34_10560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN34_10570	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN34_10575	COG3734	2-keto-3-deoxy-galactonokinase
ISN34_10590	COG0800	Aldolase
ISN34_10625	COG0784	Response regulator, receiver
ISN34_10625	COG2198	Histidine kinase
ISN34_10625	COG2205	protein histidine kinase activity
ISN34_10630	COG1024	Enoyl-CoA hydratase
ISN34_10635	COG0318	PFAM AMP-dependent synthetase and ligase
ISN34_10690	COG0840	transmembrane signaling receptor activity
ISN34_10700	COG0840	transmembrane signaling receptor activity
ISN34_10710	COG0835	chemotaxis
ISN34_10720	COG0840	transmembrane signaling receptor activity
ISN34_10730	COG0840	transmembrane signaling receptor activity
ISN34_10735	COG0840	transmembrane signaling receptor activity
ISN34_10740	COG0840	transmembrane signaling receptor activity
ISN34_10745	COG0840	transmembrane signaling receptor activity
ISN34_10755	COG0840	transmembrane signaling receptor activity
ISN34_10755	COG0840	transmembrane signaling receptor activity
ISN34_10760	COG0840	transmembrane signaling receptor activity
ISN34_10765	COG0840	transmembrane signaling receptor activity
ISN34_10770	COG0840	transmembrane signaling receptor activity
ISN34_10785	COG0745	RESPONSE REGULATOR receiver
ISN34_10800	COG1192	Involved in chromosome partitioning
ISN34_10810	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN34_10815	COG2198	Histidine kinase
ISN34_10815	COG0784	Response regulator, receiver
ISN34_10815	COG0643	Histidine kinase
ISN34_10820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN34_10865	COG1684	flagellar biosynthetic protein fliR
ISN34_10870	COG1987	bacterial-type flagellum assembly
ISN34_10880	COG3190	flagellar
ISN34_10930	COG1677	Flagellar hook-basal body complex protein FliE
ISN34_10970	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_10975	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_10980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN34_11000	COG2201	protein-glutamate methylesterase activity
ISN34_11005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISN34_11010	COG2197	response regulator
ISN34_11030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN34_11035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN34_11040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN34_11045	COG4786	Flagellar basal body rod
ISN34_11045	COG1256	bacterial-type flagellum assembly
ISN34_11045	COG1256	bacterial-type flagellum assembly
ISN34_11045	COG4786	Flagellar basal body rod
ISN34_11060	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN34_11075	COG1749	Flagellar hook protein flgE
ISN34_11085	COG1558	bacterial-type flagellum-dependent cell motility
ISN34_11095	COG0784	Response regulator, receiver
ISN34_11095	COG0835	chemotaxis
ISN34_11155	COG2915	High frequency lysogenization protein hflD homolog
ISN34_11160	COG0482	sulfurtransferase activity
ISN34_11180	COG0542	response to heat
ISN34_11200	COG0492	ferredoxin-NADP+ reductase activity
ISN34_11205	COG1674	ftsk spoiiie
ISN34_11225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN34_11230	COG0038	chloride channel
ISN34_11275	COG1404	Belongs to the peptidase S8 family
ISN34_11285	COG1595	DNA-templated transcription, initiation
ISN34_11305	COG3038	cytochrome b561
ISN34_11335	COG2244	polysaccharide biosynthetic process
ISN34_11355	COG4106	trans-aconitate 2-methyltransferase activity
ISN34_11375	COG0438	transferase activity, transferring glycosyl groups
ISN34_11380	COG0438	transferase activity, transferring glycosyl groups
ISN34_11400	COG1132	(ABC) transporter
ISN34_11435	COG1022	Amp-dependent synthetase and ligase
ISN34_11460	COG0512	Glutamine amidotransferase of anthranilate synthase
ISN34_11475	COG2801	Transposase and inactivated derivatives
ISN34_11500	COG1530	ribonuclease E activity
ISN34_11515	COG0428	transporter
ISN34_11530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN34_11530	COG0316	Belongs to the HesB IscA family
ISN34_11550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN34_11570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN34_11575	COG2957	Belongs to the agmatine deiminase family
ISN34_11585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN34_11590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN34_11595	COG0539	negative regulation of cytoplasmic translation
ISN34_11600	COG0776	regulation of translation
ISN34_11610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN34_11615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN34_11625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN34_11630	COG0183	Belongs to the thiolase family
ISN34_11635	COG1024	Enoyl-CoA hydratase
ISN34_11635	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN34_11650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN34_11660	COG1426	Protein conserved in bacteria
ISN34_11670	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN34_11680	COG0746	molybdenum cofactor guanylyltransferase activity
ISN34_11690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN34_11695	COG0475	glutathione-regulated potassium exporter activity
ISN34_11695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN34_11710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN34_11720	COG0519	Catalyzes the synthesis of GMP from XMP
ISN34_11720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN34_11780	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN34_11785	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN34_11795	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN34_11810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN34_11815	COG0668	transmembrane transport
ISN34_11825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN34_11840	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_11845	COG1183	phosphatidylcholine synthase activity
ISN34_11855	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN34_11885	COG0784	Response regulator, receiver
ISN34_11885	COG4191	Histidine kinase
ISN34_11890	COG2183	response to ionizing radiation
ISN34_11895	COG2205	protein histidine kinase activity
ISN34_11895	COG0784	Response regulator, receiver
ISN34_11960	COG1649	PFAM Uncharacterised BCR, COG1649
ISN34_11965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN34_11970	COG1304	FMN binding
ISN34_11980	COG0346	lactoylglutathione lyase activity
ISN34_11995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN34_12020	COG1024	Enoyl-CoA hydratase
ISN34_12025	COG1024	Enoyl-CoA hydratase
ISN34_12035	COG1024	Enoyl-CoA hydratase
ISN34_12055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN34_12200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISN34_12210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN34_12215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN34_12225	COG0505	Belongs to the CarA family
ISN34_12235	COG2258	MOSC domain
ISN34_12240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN34_12270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN34_12280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN34_12285	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN34_12330	COG0464	growth
ISN34_12365	COG0494	nUDIX hydrolase
ISN34_12375	COG2814	Major facilitator Superfamily
ISN34_12430	COG0629	single-stranded DNA binding
ISN34_12435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN34_12690	COG0583	DNA-binding transcription factor activity
ISN34_12695	COG0582	viral genome integration into host DNA
ISN34_12705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN34_12720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN34_12730	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN34_12735	COG1132	(ABC) transporter
ISN34_12745	COG0811	peptide transport
ISN34_12770	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN34_12780	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN34_12795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN34_12800	COG2009	succinate dehydrogenase
ISN34_12815	COG3842	ATPase activity
ISN34_12820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN34_12835	COG0129	dihydroxy-acid dehydratase activity
ISN34_12850	COG0395	ABC-type sugar transport system, permease component
ISN34_12885	COG2350	Protein conserved in bacteria
ISN34_12890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN34_12895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN34_12900	COG1187	pseudouridine synthase activity
ISN34_12925	COG0436	Aminotransferase
ISN34_12930	COG4133	protoheme IX ABC transporter activity
ISN34_12975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN34_12980	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN34_12985	COG4988	ABC transporter
ISN34_12995	COG1294	oxidase, subunit
ISN34_13050	COG2137	regulation of response to DNA damage stimulus
ISN34_13055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN34_13060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN34_13065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN34_13070	COG1546	Belongs to the CinA family
ISN34_13075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN34_13085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN34_13090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN34_13095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN34_13100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN34_13105	COG1534	Rna-binding protein
ISN34_13120	COG1238	metal cluster binding
ISN34_13130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN34_13145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN34_13150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN34_13155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ISN34_13170	COG0504	CTP synthase activity
ISN34_13190	COG0306	phosphate transporter
ISN34_13200	COG1253	flavin adenine dinucleotide binding
ISN34_13215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN34_13250	COG0069	glutamate synthase activity
ISN34_13255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN34_13265	COG1609	Transcriptional regulator
ISN34_13270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN34_13270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN34_13275	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN34_13280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN34_13280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN34_13310	COG0577	efflux transmembrane transporter activity
ISN34_13310	COG1136	(ABC) transporter
ISN34_13350	COG0583	DNA-binding transcription factor activity
ISN34_13375	COG1605	Chorismate mutase
ISN34_13375	COG0077	Prephenate dehydratase
ISN34_13380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN34_13385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN34_13425	COG4221	oxidoreductase activity
ISN34_13440	COG1228	amidohydrolase
ISN34_13455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN34_13490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN34_13500	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN34_13510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN34_13545	COG0316	Belongs to the HesB IscA family
ISN34_13620	COG0288	reversible hydration of carbon dioxide
ISN34_13630	COG1289	transmembrane transporter activity
ISN34_13635	COG3844	kynureninase activity
ISN34_13645	COG2925	Exonuclease
ISN34_13695	COG2902	Dehydrogenase
ISN34_13705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN34_13710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN34_13740	COG1960	acyl-CoA dehydrogenase activity
ISN34_13745	COG2226	methyltransferase
ISN34_13750	COG0646	methionine synthase
ISN34_13750	COG1410	methionine synthase
ISN34_13755	COG0646	methionine synthase
ISN34_13755	COG1410	methionine synthase
ISN34_13775	COG2900	Belongs to the SlyX family
ISN34_13790	COG0386	Belongs to the glutathione peroxidase family
ISN34_13800	COG1725	Transcriptional regulator
ISN34_13805	COG1131	(ABC) transporter
ISN34_13860	COG2850	peptidyl-arginine hydroxylation
ISN34_13910	COG1132	(ABC) transporter
ISN34_13920	COG1605	Chorismate mutase
ISN34_13920	COG0287	Prephenate dehydrogenase
ISN34_13925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN34_13935	COG0484	heat shock protein binding
ISN34_13940	COG0443	Heat shock 70 kDa protein
ISN34_13945	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN34_13950	COG1420	regulation of RNA biosynthetic process
ISN34_13955	COG0497	DNA recombination
ISN34_13960	COG0735	belongs to the Fur family
ISN34_13965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN34_13975	COG2867	negative regulation of translational initiation
ISN34_13980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN34_13990	COG1404	Belongs to the peptidase S8 family
ISN34_14030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN34_14045	COG0583	DNA-binding transcription factor activity
ISN34_14060	COG0415	Belongs to the DNA photolyase family
ISN34_14065	COG0305	Participates in initiation and elongation during chromosome replication
ISN34_14075	COG1960	acyl-CoA dehydrogenase activity
ISN34_14090	COG0084	hydrolase, TatD family'
ISN34_14095	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN34_14170	COG0386	Belongs to the glutathione peroxidase family
ISN34_14185	COG1846	Transcriptional regulator
ISN34_14225	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN34_14235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN34_14255	COG0488	(ABC) transporter
ISN34_14260	COG0513	Belongs to the DEAD box helicase family
ISN34_14285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN34_14290	COG0657	acetylesterase activity
ISN34_14295	COG0625	glutathione transferase activity
ISN34_14305	COG0564	pseudouridine synthase activity
ISN34_14310	COG4681	YaeQ
ISN34_14315	COG2081	HI0933 family
ISN34_14335	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_14360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN34_14365	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN34_14370	COG0802	atpase or kinase
ISN34_14375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN34_14375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN34_14380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN34_14385	COG1570	exodeoxyribonuclease VII activity
ISN34_14420	COG1960	acyl-CoA dehydrogenase activity
ISN34_14430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN34_14450	COG0438	transferase activity, transferring glycosyl groups
ISN34_14460	COG0438	transferase activity, transferring glycosyl groups
ISN34_14465	COG0438	transferase activity, transferring glycosyl groups
ISN34_14515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN34_14520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN34_14530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN34_14630	COG2948	multi-organism process
ISN34_14665	COG0556	nucleotide-excision repair
ISN34_14710	COG3275	phosphorelay sensor kinase activity
ISN34_14715	COG1611	Belongs to the LOG family
ISN34_14725	COG2095	MarC family integral membrane protein
ISN34_14730	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_14735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN34_14775	COG2969	positive regulation of protein catabolic process
ISN34_14780	COG0625	glutathione transferase activity
ISN34_14785	COG2857	Cytochrome c1
ISN34_14795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN34_14800	COG0723	plastoquinol--plastocyanin reductase activity
ISN34_14805	COG0741	lytic transglycosylase activity
ISN34_14820	COG1702	phosphate starvation-inducible protein PhoH
ISN34_14835	COG4535	Mg2 and Co2 transporter CorC
ISN34_14850	COG1012	belongs to the aldehyde dehydrogenase family
ISN34_14860	COG1177	transmembrane transport
ISN34_14865	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN34_14870	COG3842	ATPase activity
ISN34_14890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN34_14895	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN34_14905	COG0174	glutamine synthetase
ISN34_14910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN34_14915	COG0174	glutamine synthetase
ISN34_14920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN34_14930	COG0477	Major facilitator Superfamily
ISN34_14950	COG0243	molybdopterin cofactor binding
ISN34_14960	COG2223	nitrite transmembrane transporter activity
ISN34_14980	COG1012	belongs to the aldehyde dehydrogenase family
ISN34_14985	COG1917	Cupin 2, conserved barrel domain protein
ISN34_14985	COG1396	sequence-specific DNA binding
ISN34_14990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN34_14995	COG0686	Belongs to the AlaDH PNT family
ISN34_15015	COG2733	membrane
ISN34_15020	COG5002	protein histidine kinase activity
ISN34_15020	COG0784	Response regulator, receiver
ISN34_15020	COG2205	protein histidine kinase activity
ISN34_15080	COG1024	Enoyl-CoA hydratase
ISN34_15090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN34_15095	COG0659	secondary active sulfate transmembrane transporter activity
ISN34_15115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN34_15120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN34_15130	COG0581	inorganic phosphate transmembrane transporter activity
ISN34_15140	COG0704	Plays a role in the regulation of phosphate uptake
ISN34_15160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN34_15170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN34_15180	COG0557	exoribonuclease II activity
ISN34_15215	COG2814	Major facilitator Superfamily
ISN34_15220	COG1566	PFAM secretion protein HlyD family protein
ISN34_15255	COG0367	asparagine synthase
ISN34_15265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN34_15270	COG1393	Belongs to the ArsC family
ISN34_15285	COG0024	Methionine aminopeptidase
ISN34_15325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN34_15335	COG0528	UMP kinase activity
ISN34_15345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN34_15350	COG0575	Belongs to the CDS family
ISN34_15355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN34_15360	COG0750	zinc metalloprotease
ISN34_15365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN34_15370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN34_15380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN34_15385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN34_15410	COG1981	membrane
ISN34_15450	COG0583	DNA-binding transcription factor activity
ISN34_15475	COG1132	(ABC) transporter
ISN34_15525	COG1187	pseudouridine synthase activity
ISN34_15630	COG2080	2 iron, 2 sulfur cluster binding
ISN34_15635	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN34_15640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN34_15675	COG0735	belongs to the Fur family
ISN34_15680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN34_15710	COG2205	protein histidine kinase activity
ISN34_15720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN34_15725	COG3878	Protein conserved in bacteria
ISN34_15740	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN34_15750	COG0643	Histidine kinase
ISN34_15750	COG2198	Histidine kinase
ISN34_15755	COG0840	transmembrane signaling receptor activity
ISN34_15760	COG0840	transmembrane signaling receptor activity
ISN34_15765	COG0840	transmembrane signaling receptor activity
ISN34_15770	COG0835	chemotaxis
ISN34_15775	COG4251	negative regulation of phosphorylation
ISN34_15775	COG5001	Diguanylate cyclase
ISN34_15775	COG3706	GGDEF domain
ISN34_15775	COG2203	Gaf domain
ISN34_15805	COG2211	Major facilitator Superfamily
ISN34_15820	COG0588	phosphoglycerate mutase activity
ISN34_15840	COG1966	Carbon starvation protein
ISN34_15845	COG2879	small protein
ISN34_15850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN34_15870	COG0823	Involved in the tonB-independent uptake of proteins
ISN34_15870	COG1506	peptidase
ISN34_15875	COG1297	OPT oligopeptide transporter protein
ISN34_15880	COG3104	oligopeptide transport
ISN34_15895	COG3550	peptidyl-serine autophosphorylation
ISN34_15900	COG0629	single-stranded DNA binding
ISN34_15905	COG0142	geranyltranstransferase activity
ISN34_15930	COG0527	aspartate kinase activity
ISN34_15935	COG0384	phenazine biosynthesis protein PhzF
ISN34_15945	COG1764	response to oxidative stress
ISN34_15960	COG0739	heme binding
ISN34_15975	COG0693	protein deglycase activity
ISN34_15990	COG0719	Fe-S assembly protein
ISN34_15995	COG0396	ATPase activity
ISN34_16000	COG0719	Fe-S assembly protein
ISN34_16005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN34_16015	COG2146	nitrite reductase [NAD(P)H] activity
ISN34_16020	COG4774	siderophore transport
ISN34_16045	COG1477	protein flavinylation
ISN34_16050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN34_16070	COG1555	photosystem II stabilization
ISN34_16085	COG3178	'Phosphotransferase
ISN34_16090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN34_16100	COG0628	permease
ISN34_16125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN34_16170	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN34_16185	COG1137	ATPase activity
ISN34_16200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN34_16210	COG1660	Displays ATPase and GTPase activities
ISN34_16220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN34_16225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN34_16230	COG2239	Acts as a magnesium transporter
ISN34_16250	COG1113	amino acid transport
ISN34_16260	COG0840	transmembrane signaling receptor activity
ISN34_16280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN34_16295	COG0519	Catalyzes the synthesis of GMP from XMP
ISN34_16375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN34_16380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN34_16390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN34_16395	COG2814	Major facilitator Superfamily
ISN34_16415	COG3038	cytochrome b561
ISN34_16430	COG1760	l-serine dehydratase
ISN34_16440	COG2267	carboxylic ester hydrolase activity
ISN34_16445	COG0527	aspartate kinase activity
ISN34_16445	COG0460	homoserine dehydrogenase
ISN34_16450	COG0626	cystathionine gamma-synthase activity
ISN34_16455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN34_16465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN34_16470	COG1272	protein, Hemolysin III
ISN34_16475	COG2982	Protein involved in outer membrane biogenesis
ISN34_16480	COG0517	IMP dehydrogenase activity
ISN34_16485	COG0463	Glycosyl transferase, family 2
ISN34_16490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN34_16495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN34_16505	COG4206	TonB-dependent receptor
ISN34_16525	COG1304	FMN binding
ISN34_16535	COG1657	PFAM Prenyltransferase squalene oxidase
ISN34_16540	COG0142	geranyltranstransferase activity
ISN34_16545	COG2124	cytochrome p450
ISN34_16550	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_16555	COG1141	Ferredoxin
ISN34_16560	COG2124	cytochrome p450
ISN34_16565	COG2124	cytochrome p450
ISN34_16625	COG0330	HflC and HflK could
ISN34_16630	COG1742	UPF0060 membrane protein
ISN34_16635	COG3956	TIGRFAM MazG family protein
ISN34_16640	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN34_16645	COG0494	nUDIX hydrolase
ISN34_16655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN34_16665	COG0837	glucose binding
ISN34_16680	COG3858	chitin binding
ISN34_16680	COG1388	LysM domain
ISN34_16685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN34_16695	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN34_16715	COG3537	Alpha-1,2-mannosidase
ISN34_16820	COG5297	Belongs to the glycosyl hydrolase family 6
ISN34_16825	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN34_16845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN34_16850	COG1295	ribonuclease BN
ISN34_16900	COG1404	Belongs to the peptidase S8 family
ISN34_16905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN34_16945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN34_17055	COG4651	solute:proton antiporter activity
ISN34_17055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN34_17065	COG4772	TonB-dependent receptor
ISN34_17075	COG4264	IucA IucC family
ISN34_17080	COG2814	Major facilitator Superfamily
ISN34_17085	COG4264	IucA IucC family
ISN34_17090	COG0019	diaminopimelate decarboxylase activity
ISN34_17120	COG0542	response to heat
ISN34_17170	COG3387	PFAM Glycoside hydrolase 15-related
ISN34_17195	COG0564	pseudouridine synthase activity
ISN34_17200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN34_17210	COG1125	glycine betaine transport
ISN34_17215	COG1174	glycine betaine transport
ISN34_17230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN34_17240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN34_17240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN34_17280	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN34_17305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN34_17325	COG0745	RESPONSE REGULATOR receiver
ISN34_17335	COG0189	ligase activity
ISN34_17345	COG3511	phospholipase C
ISN34_17370	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN34_17385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN34_17395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN34_17400	COG0174	glutamine synthetase
ISN34_17420	COG2022	thiamine diphosphate biosynthetic process
ISN34_17430	COG3273	potassium ion transport
ISN34_17430	COG0471	metal ion transport
ISN34_17445	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN34_17465	COG1609	Transcriptional regulator
ISN34_17480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN34_17510	COG0840	transmembrane signaling receptor activity
ISN34_17515	COG0529	Catalyzes the synthesis of activated sulfate
ISN34_17515	COG2895	sulfate adenylyltransferase (ATP) activity
ISN34_17525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN34_17530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN34_17535	COG0175	sulfate reduction
ISN34_17565	COG1393	Belongs to the ArsC family
ISN34_17570	COG2205	protein histidine kinase activity
ISN34_17570	COG0784	Response regulator, receiver
ISN34_17570	COG2198	Histidine kinase
ISN34_17600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN34_17635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN34_17640	COG3588	fructose-bisphosphate aldolase
ISN34_17645	COG0469	pyruvate kinase activity
ISN34_17690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN34_17695	COG3047	cAMP biosynthetic process
ISN34_17715	COG0640	Transcriptional regulator
ISN34_17725	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN34_17730	COG4149	molybdate abc transporter
ISN34_17735	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN34_17760	COG1376	ErfK ybiS ycfS ynhG family protein
ISN34_17765	COG0739	heme binding
ISN34_17800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN34_17805	COG1301	dicarboxylic acid transport
ISN34_17835	COG0714	Associated with various cellular activities
ISN34_17865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN34_17880	COG0372	Belongs to the citrate synthase family
ISN34_17885	COG0254	rRNA binding
ISN34_17900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN34_17915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN34_17920	COG1758	RNA polymerase activity
ISN34_17925	COG0194	GDP metabolic process
ISN34_17930	COG1561	YicC-like family, N-terminal region
ISN34_17935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN34_17940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN34_17945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN34_17965	COG0006	proline dipeptidase activity
ISN34_17970	COG0006	proline dipeptidase activity
ISN34_17975	COG3079	Belongs to the UPF0149 family
ISN34_18000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN34_18010	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN34_18030	COG1773	rubredoxin
ISN34_18050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN34_18060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN34_18070	COG1940	carbohydrate kinase activity
ISN34_18085	COG0671	phosphoesterase, PA-phosphatase related
ISN34_18100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN34_18120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN34_18130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN34_18150	COG0840	transmembrane signaling receptor activity
ISN34_18155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN34_18175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN34_18185	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN34_18195	COG0066	3-isopropylmalate dehydratase activity
ISN34_18200	COG0473	3-isopropylmalate dehydrogenase activity
ISN34_18205	COG3706	GGDEF domain
ISN34_18215	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN34_18220	COG1538	Outer membrane efflux protein
ISN34_18225	COG1519	Transferase
ISN34_18230	COG1560	Kdo2-lipid A biosynthetic process
ISN34_18295	COG0281	malic enzyme
ISN34_18295	COG0280	phosphate acetyltransferase
ISN34_18300	COG1301	dicarboxylic acid transport
ISN34_18310	COG4191	Histidine kinase
ISN34_18330	COG0642	Histidine kinase
ISN34_18345	COG2851	Citrate transporter
ISN34_18350	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_18360	COG2211	Major facilitator Superfamily
ISN34_18385	COG1162	GTPase activity
ISN34_18415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN34_18435	COG1228	amidohydrolase
ISN34_18485	COG3791	Glutathione-dependent formaldehyde-activating
ISN34_18490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN34_18505	COG2205	protein histidine kinase activity
ISN34_18530	COG2207	Transcriptional regulator
ISN34_18555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN34_18575	COG0617	tRNA 3'-terminal CCA addition
ISN34_18585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN34_18590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN34_18595	COG1609	Transcriptional regulator
ISN34_18600	COG0738	Major facilitator superfamily
ISN34_18605	COG2188	Transcriptional regulator
ISN34_18620	COG3250	beta-galactosidase activity
ISN34_18650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN34_18660	COG4191	Histidine kinase
ISN34_18665	COG0784	Response regulator, receiver
ISN34_18670	COG2202	Pas domain
ISN34_18670	COG2205	protein histidine kinase activity
ISN34_18680	COG2823	Periplasmic or secreted lipoprotein
ISN34_18685	COG0673	inositol 2-dehydrogenase activity
ISN34_18690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN34_18700	COG1090	epimerase
ISN34_18720	COG1051	belongs to the nudix hydrolase family
ISN34_18720	COG1056	cytidyltransferase-related domain
ISN34_18765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN34_18770	COG0321	lipoyl(octanoyl) transferase activity
ISN34_18820	COG1686	Belongs to the peptidase S11 family
ISN34_18830	COG2951	lytic endotransglycosylase activity
ISN34_18845	COG0772	Belongs to the SEDS family
ISN34_18850	COG0768	penicillin binding
ISN34_18860	COG1792	Involved in formation and maintenance of cell shape
ISN34_18865	COG1077	Cell shape determining protein MreB Mrl
ISN34_18870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN34_18875	COG3284	Transcriptional regulator
ISN34_18885	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN34_18895	COG2010	Cytochrome c
ISN34_18920	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN34_18920	COG0596	Alpha beta hydrolase
ISN34_18925	COG0308	aminopeptidase N
ISN34_18930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN34_18940	COG2226	methyltransferase
ISN34_18965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISN34_18985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN34_18995	COG2832	Protein of unknown function (DUF454)
ISN34_19005	COG0436	Aminotransferase
ISN34_19010	COG1505	serine-type exopeptidase activity
ISN34_19025	COG1733	regulation of RNA biosynthetic process
ISN34_19050	COG0181	hydroxymethylbilane synthase activity
ISN34_19075	COG0745	RESPONSE REGULATOR receiver
ISN34_19095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN34_19100	COG1640	4-alpha-glucanotransferase
ISN34_19130	COG0243	molybdopterin cofactor binding
ISN34_19135	COG2146	nitrite reductase [NAD(P)H] activity
ISN34_19140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN34_19145	COG2223	nitrite transmembrane transporter activity
ISN34_19180	COG3645	SOS response
ISN34_19195	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN34_19220	COG2204	response regulator
ISN34_19225	COG4191	Histidine kinase
ISN34_19230	COG0028	Belongs to the TPP enzyme family
ISN34_19245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN34_19260	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN34_19270	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_19275	COG3685	Protein conserved in bacteria
ISN34_19280	COG3685	Protein conserved in bacteria
ISN34_19285	COG3546	catalase activity
ISN34_19305	COG0840	transmembrane signaling receptor activity
ISN34_19345	COG1309	transcriptional regulator
ISN34_19420	COG0366	Alpha amylase catalytic
ISN34_19425	COG0366	Alpha amylase catalytic
ISN34_19435	COG1609	Transcriptional regulator
ISN34_19465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN34_19470	COG1490	D-aminoacyl-tRNA deacylase activity
ISN34_19485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN34_19510	COG3307	-O-antigen
ISN34_19520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN34_19525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN34_19525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN34_19530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN34_19535	COG0242	peptide deformylase activity
ISN34_19540	COG1652	LysM domain
ISN34_19545	COG0758	DNA mediated transformation
ISN34_19560	COG1714	RDD family
ISN34_19565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN34_19565	COG1754	DNA topoisomerase type I activity
ISN34_19570	COG0009	L-threonylcarbamoyladenylate synthase
ISN34_19585	COG1028	Short-chain dehydrogenase reductase Sdr
ISN34_19595	COG0616	signal peptide processing
ISN34_19600	COG0534	Mate efflux family protein
ISN34_19610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN34_19620	COG1252	NADH dehydrogenase
ISN34_19625	COG2860	membrane
ISN34_19630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN34_19635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN34_19640	COG2201	protein-glutamate methylesterase activity
ISN34_19645	COG2177	Part of the ABC transporter FtsEX involved in
ISN34_19650	COG2884	Cell division ATP-binding protein ftsE
ISN34_19660	COG3118	belongs to the thioredoxin family
ISN34_19665	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN34_19675	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN34_19685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN34_19725	COG1518	maintenance of DNA repeat elements
ISN34_19730	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN34_19740	COG1652	LysM domain
ISN34_19755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN34_19760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN34_19775	COG5383	Protein conserved in bacteria
ISN34_19810	COG3501	Rhs element vgr protein
ISN34_19810	COG3409	Peptidoglycan-binding domain 1 protein
ISN34_19840	COG4771	TonB-dependent receptor
ISN34_19850	COG4948	Mandelate Racemase Muconate Lactonizing
ISN34_19860	COG0531	amino acid
ISN34_19880	COG2133	pyrroloquinoline quinone binding
ISN34_19895	COG2308	Evidence 4 Homologs of previously reported genes of
ISN34_19910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN34_19930	COG1295	ribonuclease BN
ISN34_19935	COG0358	DNA primase activity
ISN34_19950	COG0109	protoheme IX farnesyltransferase activity
ISN34_19985	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN34_19990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN34_19995	COG1565	acr, cog1565
ISN34_19995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN34_20015	COG1486	melibiose metabolic process
ISN34_20020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ISN34_20020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ISN34_20025	COG0531	amino acid
ISN34_20060	COG0793	Belongs to the peptidase S41A family
ISN34_20065	COG4942	peptidase
ISN34_20075	COG2234	aminopeptidase activity
ISN34_20080	COG1064	alcohol dehydrogenase