locus-tag	class	description
LTC53_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LTC53_00020	COG0187	DNA topoisomerase II activity
LTC53_00025	COG1266	CAAX protease self-immunity
LTC53_00030	COG0501	Belongs to the peptidase M48B family
LTC53_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LTC53_00100	COG1280	lysine exporter protein (LysE YggA)
LTC53_00115	COG4772	TonB-dependent receptor
LTC53_00125	COG3284	Transcriptional regulator
LTC53_00130	COG1012	belongs to the aldehyde dehydrogenase family
LTC53_00165	COG1304	FMN binding
LTC53_00195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LTC53_00270	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LTC53_00290	COG4771	TonB-dependent receptor
LTC53_00335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LTC53_00350	COG3507	Belongs to the glycosyl hydrolase 43 family
LTC53_00355	COG1609	Transcriptional regulator
LTC53_00365	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_00380	COG3186	Phenylalanine-4-hydroxylase
LTC53_00385	COG1522	sequence-specific DNA binding
LTC53_00410	COG1752	Esterase of the alpha-beta hydrolase superfamily
LTC53_00415	COG1473	amidohydrolase
LTC53_00420	COG1473	amidohydrolase
LTC53_00435	COG0671	phosphoesterase, PA-phosphatase related
LTC53_00450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LTC53_00485	COG1929	Belongs to the glycerate kinase type-1 family
LTC53_00495	COG0531	amino acid
LTC53_00500	COG4566	intracellular signal transduction
LTC53_00505	COG4191	Histidine kinase
LTC53_00525	COG1322	Protein conserved in bacteria
LTC53_00530	COG0386	Belongs to the glutathione peroxidase family
LTC53_00535	COG2853	Lipoprotein
LTC53_00550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LTC53_00555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LTC53_00560	COG1127	ABC transporter
LTC53_00565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LTC53_00575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LTC53_00595	COG0537	adenosine 5'-monophosphoramidase activity
LTC53_00665	COG0477	Major facilitator Superfamily
LTC53_00670	COG0302	gtp cyclohydrolase
LTC53_00695	COG0730	response to heat
LTC53_00710	COG2951	lytic endotransglycosylase activity
LTC53_00770	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LTC53_00775	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LTC53_00780	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LTC53_00785	COG0493	'glutamate synthase
LTC53_00790	COG0067	glutamate synthase
LTC53_00790	COG0069	glutamate synthase activity
LTC53_00790	COG0070	glutamate synthase
LTC53_00835	COG1205	dead DEAH box helicase
LTC53_00835	COG1111	helicase
LTC53_00870	COG2271	Major facilitator Superfamily
LTC53_00920	COG1192	Involved in chromosome partitioning
LTC53_00925	COG2062	phosphohistidine phosphatase, SixA
LTC53_00935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LTC53_00940	COG2050	protein possibly involved in aromatic compounds catabolism
LTC53_00950	COG2267	carboxylic ester hydrolase activity
LTC53_00965	COG1881	PFAM PEBP family protein
LTC53_00970	COG1968	undecaprenyl-diphosphatase activity
LTC53_00975	COG0174	glutamine synthetase
LTC53_00980	COG0347	Belongs to the P(II) protein family
LTC53_00985	COG0004	ammonium transporteR
LTC53_00990	COG3852	Histidine kinase
LTC53_00995	COG2204	response regulator
LTC53_01000	COG2032	superoxide dismutase activity
LTC53_01005	COG2032	superoxide dismutase activity
LTC53_01015	COG0183	Belongs to the thiolase family
LTC53_01055	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LTC53_01060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LTC53_01070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LTC53_01080	COG0612	Peptidase, M16
LTC53_01090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LTC53_01100	COG0596	Alpha beta hydrolase
LTC53_01110	COG0727	PFAM Uncharacterised protein family (UPF0153)
LTC53_01115	COG0318	PFAM AMP-dependent synthetase and ligase
LTC53_01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LTC53_01140	COG1181	Belongs to the D-alanine--D-alanine ligase family
LTC53_01155	COG4232	protein-disulfide reductase activity
LTC53_01160	COG0564	pseudouridine synthase activity
LTC53_01180	COG0339	signal peptide processing
LTC53_01200	COG0583	DNA-binding transcription factor activity
LTC53_01205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LTC53_01210	COG2224	Isocitrate lyase
LTC53_01245	COG0659	secondary active sulfate transmembrane transporter activity
LTC53_01280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LTC53_01285	COG2130	NADP-dependent
LTC53_01300	COG1187	pseudouridine synthase activity
LTC53_01310	COG1643	Atp-dependent helicase
LTC53_01315	COG0084	hydrolase, TatD family'
LTC53_01330	COG0842	Transport permease protein
LTC53_01335	COG1131	(ABC) transporter
LTC53_01340	COG0543	2 iron, 2 sulfur cluster binding
LTC53_01340	COG0633	Ferredoxin
LTC53_01350	COG1476	TRANSCRIPTIONal
LTC53_01360	COG4555	ABC transporter
LTC53_01380	COG0625	glutathione transferase activity
LTC53_01455	COG1199	ATP-dependent helicase activity
LTC53_01500	COG0628	permease
LTC53_01515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LTC53_01535	COG0628	permease
LTC53_01545	COG2133	pyrroloquinoline quinone binding
LTC53_01595	COG0754	glutathionylspermidine amidase activity
LTC53_01605	COG0714	Associated with various cellular activities
LTC53_01650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LTC53_01665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LTC53_01670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LTC53_01695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LTC53_01715	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_01730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LTC53_01740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LTC53_01755	COG0582	viral genome integration into host DNA
LTC53_01800	COG0484	heat shock protein binding
LTC53_01925	COG0606	chelatase, subunit chli
LTC53_01930	COG2960	long-chain fatty acid transporting porin activity
LTC53_01955	COG1166	arginine decarboxylase activity
LTC53_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LTC53_01975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LTC53_01975	COG2755	lipolytic protein G-D-S-L family
LTC53_01980	COG0583	DNA-binding transcription factor activity
LTC53_02000	COG4221	oxidoreductase activity
LTC53_02020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LTC53_02040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LTC53_02050	COG2814	Major facilitator Superfamily
LTC53_02065	COG0739	heme binding
LTC53_02070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LTC53_02100	COG1064	alcohol dehydrogenase
LTC53_02105	COG2234	aminopeptidase activity
LTC53_02115	COG4942	peptidase
LTC53_02120	COG0793	Belongs to the peptidase S41A family
LTC53_02150	COG0531	amino acid
LTC53_02170	COG1565	acr, cog1565
LTC53_02170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LTC53_02175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LTC53_02180	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LTC53_02215	COG0109	protoheme IX farnesyltransferase activity
LTC53_02230	COG0358	DNA primase activity
LTC53_02235	COG1295	ribonuclease BN
LTC53_02255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LTC53_02260	COG2308	Evidence 4 Homologs of previously reported genes of
LTC53_02275	COG2133	pyrroloquinoline quinone binding
LTC53_02295	COG0531	amino acid
LTC53_02305	COG4948	Mandelate Racemase Muconate Lactonizing
LTC53_02315	COG4771	TonB-dependent receptor
LTC53_02320	COG3023	N-Acetylmuramoyl-L-alanine amidase
LTC53_02370	COG5383	Protein conserved in bacteria
LTC53_02385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LTC53_02390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LTC53_02405	COG1652	LysM domain
LTC53_02415	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LTC53_02420	COG1518	maintenance of DNA repeat elements
LTC53_02465	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LTC53_02475	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LTC53_02480	COG3118	belongs to the thioredoxin family
LTC53_02490	COG2884	Cell division ATP-binding protein ftsE
LTC53_02495	COG2177	Part of the ABC transporter FtsEX involved in
LTC53_02500	COG2201	protein-glutamate methylesterase activity
LTC53_02505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LTC53_02510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LTC53_02520	COG1252	NADH dehydrogenase
LTC53_02530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LTC53_02540	COG0534	Mate efflux family protein
LTC53_02545	COG0616	signal peptide processing
LTC53_02555	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_02570	COG0009	L-threonylcarbamoyladenylate synthase
LTC53_02575	COG1754	DNA topoisomerase type I activity
LTC53_02575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LTC53_02580	COG1714	RDD family
LTC53_02600	COG0758	DNA mediated transformation
LTC53_02605	COG1652	LysM domain
LTC53_02610	COG0242	peptide deformylase activity
LTC53_02615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LTC53_02620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LTC53_02620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LTC53_02625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LTC53_02660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LTC53_02665	COG1247	-acetyltransferase
LTC53_02675	COG1490	D-aminoacyl-tRNA deacylase activity
LTC53_02680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LTC53_02715	COG1609	Transcriptional regulator
LTC53_02725	COG0366	Alpha amylase catalytic
LTC53_02730	COG0366	Alpha amylase catalytic
LTC53_02780	COG1309	transcriptional regulator
LTC53_02830	COG0840	transmembrane signaling receptor activity
LTC53_02845	COG3546	catalase activity
LTC53_02850	COG3685	Protein conserved in bacteria
LTC53_02855	COG3685	Protein conserved in bacteria
LTC53_02860	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_02870	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LTC53_02885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LTC53_02900	COG0028	Belongs to the TPP enzyme family
LTC53_02905	COG4191	Histidine kinase
LTC53_02910	COG2204	response regulator
LTC53_02935	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LTC53_02965	COG1648	precorrin-2 dehydrogenase activity
LTC53_02965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LTC53_02975	COG1116	anion transmembrane transporter activity
LTC53_02975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LTC53_02980	COG2223	nitrite transmembrane transporter activity
LTC53_02985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LTC53_02990	COG2146	nitrite reductase [NAD(P)H] activity
LTC53_02995	COG0243	molybdopterin cofactor binding
LTC53_03020	COG1640	4-alpha-glucanotransferase
LTC53_03025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LTC53_03045	COG0745	RESPONSE REGULATOR receiver
LTC53_03070	COG0181	hydroxymethylbilane synthase activity
LTC53_03085	COG1733	regulation of RNA biosynthetic process
LTC53_03100	COG1505	serine-type exopeptidase activity
LTC53_03115	COG0436	Aminotransferase
LTC53_03125	COG2832	Protein of unknown function (DUF454)
LTC53_03135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LTC53_03155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LTC53_03180	COG2226	methyltransferase
LTC53_03185	COG0308	aminopeptidase N
LTC53_03190	COG0508	dehydrogenase complex catalyzes the overall conversion of
LTC53_03190	COG0596	Alpha beta hydrolase
LTC53_03210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LTC53_03215	COG1077	Cell shape determining protein MreB Mrl
LTC53_03220	COG1792	Involved in formation and maintenance of cell shape
LTC53_03230	COG0768	penicillin binding
LTC53_03235	COG0772	Belongs to the SEDS family
LTC53_03250	COG2951	lytic endotransglycosylase activity
LTC53_03260	COG1686	Belongs to the peptidase S11 family
LTC53_03290	COG0321	lipoyl(octanoyl) transferase activity
LTC53_03295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LTC53_03320	COG1051	belongs to the nudix hydrolase family
LTC53_03320	COG1056	cytidyltransferase-related domain
LTC53_03355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LTC53_03360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LTC53_03365	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LTC53_03370	COG1561	YicC-like family, N-terminal region
LTC53_03375	COG0194	GDP metabolic process
LTC53_03380	COG1758	RNA polymerase activity
LTC53_03385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LTC53_03410	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LTC53_03420	COG0254	rRNA binding
LTC53_03425	COG0372	Belongs to the citrate synthase family
LTC53_03440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LTC53_03460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LTC53_03465	COG0667	Aldo Keto reductase
LTC53_03475	COG4771	TonB-dependent receptor
LTC53_03495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LTC53_03500	COG4181	ATPase activity
LTC53_03515	COG0642	Histidine kinase
LTC53_03525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LTC53_03530	COG0861	Integral membrane protein TerC family
LTC53_03535	COG1704	LemA family
LTC53_03565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LTC53_03570	COG2967	ApaG domain
LTC53_03575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LTC53_03580	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LTC53_03585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LTC53_03590	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LTC53_03600	COG2096	Adenosyltransferase
LTC53_03610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LTC53_03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LTC53_03655	COG0697	spore germination
LTC53_03660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LTC53_03690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LTC53_03705	COG0583	DNA-binding transcription factor activity
LTC53_03710	COG3634	alkyl hydroperoxide reductase activity
LTC53_03750	COG0488	(ABC) transporter
LTC53_03795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LTC53_03800	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LTC53_03815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LTC53_03825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LTC53_03835	COG0193	aminoacyl-tRNA hydrolase activity
LTC53_03840	COG0012	GTP binding
LTC53_03860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LTC53_03870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LTC53_03875	COG0250	Participates in transcription elongation, termination and antitermination
LTC53_03880	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LTC53_03895	COG0222	ribosome binding
LTC53_03905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LTC53_03920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LTC53_03925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LTC53_03930	COG0051	transcription antitermination factor activity, RNA binding
LTC53_03940	COG0088	Forms part of the polypeptide exit tunnel
LTC53_03945	COG0089	rRNA binding
LTC53_03950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LTC53_03975	COG0255	Belongs to the universal ribosomal protein uL29 family
LTC53_03980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LTC53_03990	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LTC53_03995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LTC53_04025	COG1841	ribosomal large subunit assembly
LTC53_04035	COG0201	protein transport
LTC53_04060	COG0203	ribosomal protein L17
LTC53_04065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LTC53_04075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LTC53_04090	COG1217	gtp-binding protein TYPA
LTC53_04095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LTC53_04105	COG0039	L-malate dehydrogenase activity
LTC53_04130	COG0625	glutathione transferase activity
LTC53_04175	COG0446	pyridine nucleotide-disulphide oxidoreductase
LTC53_04175	COG1902	pentaerythritol trinitrate reductase activity
LTC53_04185	COG0667	Aldo Keto reductase
LTC53_04205	COG2885	chlorophyll binding
LTC53_04220	COG0156	8-amino-7-oxononanoate synthase activity
LTC53_04225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LTC53_04230	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LTC53_04235	COG4208	sulfate ABC transporter
LTC53_04240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LTC53_04260	COG0588	phosphoglycerate mutase activity
LTC53_04265	COG0285	dihydrofolate synthase activity
LTC53_04285	COG2833	Protein of unknown function (DUF455)
LTC53_04300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LTC53_04310	COG0438	transferase activity, transferring glycosyl groups
LTC53_04320	COG0248	Ppx GppA phosphatase
LTC53_04325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LTC53_04340	COG4783	chaperone-mediated protein folding
LTC53_04355	COG0473	3-isopropylmalate dehydrogenase activity
LTC53_04395	COG0544	peptidyl-prolyl cis-trans isomerase activity
LTC53_04405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LTC53_04440	COG1388	LysM domain
LTC53_04440	COG3942	CHAP domain
LTC53_04445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LTC53_04455	COG0328	RNA-DNA hybrid ribonuclease activity
LTC53_04460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LTC53_04465	COG0631	protein serine/threonine phosphatase activity
LTC53_04485	COG0859	PFAM glycosyl transferase family 9
LTC53_04495	COG1234	tRNA 3'-trailer cleavage
LTC53_04500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LTC53_04510	COG0315	cyclic pyranopterin monophosphate synthase activity
LTC53_04515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LTC53_04520	COG0314	molybdopterin synthase activity
LTC53_04545	COG2003	Belongs to the UPF0758 family
LTC53_04700	COG0537	adenosine 5'-monophosphoramidase activity
LTC53_04720	COG0714	Associated with various cellular activities
LTC53_04745	COG1399	metal-binding, possibly nucleic acid-binding protein
LTC53_04755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LTC53_04760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LTC53_04765	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_04770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LTC53_04780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LTC53_04785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LTC53_04790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LTC53_04820	COG4115	mRNA cleavage
LTC53_04825	COG2161	toxin-antitoxin pair type II binding
LTC53_04860	COG0587	DNA-directed DNA polymerase activity
LTC53_04875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LTC53_04880	COG0372	Belongs to the citrate synthase family
LTC53_04895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LTC53_04920	COG2373	Large extracellular alpha-helical protein
LTC53_04940	COG4953	penicillin-binding protein 1C
LTC53_04950	COG0678	peroxiredoxin activity
LTC53_04970	COG0604	alcohol dehydrogenase
LTC53_04975	COG0330	HflC and HflK could
LTC53_04980	COG0330	HflC and HflK could
LTC53_04990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LTC53_05015	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LTC53_05115	COG3459	Glycosyltransferase 36 associated
LTC53_05125	COG1063	alcohol dehydrogenase
LTC53_05140	COG4106	trans-aconitate 2-methyltransferase activity
LTC53_05150	COG0753	catalase activity
LTC53_05160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LTC53_05160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LTC53_05185	COG2814	Major facilitator Superfamily
LTC53_05205	COG2194	sulfuric ester hydrolase activity
LTC53_05215	COG0745	RESPONSE REGULATOR receiver
LTC53_05220	COG2205	protein histidine kinase activity
LTC53_05230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LTC53_05235	COG2894	cell division
LTC53_05240	COG0850	regulation of cytokinetic process
LTC53_05250	COG4585	Histidine kinase
LTC53_05270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LTC53_05275	COG1216	Glycosyl transferase, family 2
LTC53_05280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LTC53_05290	COG1199	ATP-dependent helicase activity
LTC53_05310	COG0189	ligase activity
LTC53_05325	COG0835	chemotaxis
LTC53_05330	COG0840	transmembrane signaling receptor activity
LTC53_05335	COG2198	Histidine kinase
LTC53_05335	COG0784	Response regulator, receiver
LTC53_05335	COG0643	Histidine kinase
LTC53_05340	COG2201	protein-glutamate methylesterase activity
LTC53_05355	COG1446	asparaginase
LTC53_05360	COG3142	Participates in the control of copper homeostasis
LTC53_05380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LTC53_05400	COG0217	transcriptional regulatory protein
LTC53_05410	COG0632	four-way junction helicase activity
LTC53_05415	COG3158	transport of potassium into the cell
LTC53_05420	COG2255	four-way junction helicase activity
LTC53_05425	COG0824	Thioesterase
LTC53_05435	COG0848	biopolymer transport protein
LTC53_05450	COG2885	chlorophyll binding
LTC53_05460	COG0602	queuosine metabolic process
LTC53_05465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LTC53_05485	COG0514	ATP-dependent DNA helicase (RecQ)
LTC53_05490	COG0783	Belongs to the Dps family
LTC53_05495	COG1643	Atp-dependent helicase
LTC53_05540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LTC53_05585	COG4638	Rieske (2fe-2S)
LTC53_05600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LTC53_05605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LTC53_05615	COG1946	Acyl-CoA thioesterase
LTC53_05620	COG1024	Enoyl-CoA hydratase
LTC53_05630	COG0824	Thioesterase
LTC53_05635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LTC53_05640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LTC53_05645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LTC53_05665	COG0728	peptidoglycan biosynthetic process
LTC53_05690	COG0196	riboflavin kinase activity
LTC53_05705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LTC53_05725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LTC53_05730	COG1845	cytochrome c oxidase, subunit III
LTC53_05735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LTC53_05745	COG0156	8-amino-7-oxononanoate synthase activity
LTC53_05755	COG3152	Membrane
LTC53_05785	COG0745	RESPONSE REGULATOR receiver
LTC53_05815	COG4794	Type iii secretion
LTC53_05840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LTC53_05865	COG1317	bacterial-type flagellum organization
LTC53_05885	COG2207	Transcriptional regulator
LTC53_05910	COG0129	dihydroxy-acid dehydratase activity
LTC53_05930	COG1012	belongs to the aldehyde dehydrogenase family
LTC53_05935	COG1879	ABC-type sugar transport system periplasmic component
LTC53_05940	COG1129	ABC transporter
LTC53_05945	COG1172	Belongs to the binding-protein-dependent transport system permease family
LTC53_05950	COG1172	Belongs to the binding-protein-dependent transport system permease family
LTC53_05960	COG1082	Xylose isomerase domain protein TIM barrel
LTC53_05965	COG0625	glutathione transferase activity
LTC53_05975	COG0475	glutathione-regulated potassium exporter activity
LTC53_06000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LTC53_06005	COG2070	2-Nitropropane dioxygenase
LTC53_06020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LTC53_06025	COG0336	Belongs to the RNA methyltransferase TrmD family
LTC53_06030	COG0335	large ribosomal subunit rRNA binding
LTC53_06035	COG0534	Mate efflux family protein
LTC53_06045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LTC53_06065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LTC53_06080	COG2855	membrane
LTC53_06110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LTC53_06115	COG0481	GTPase activity
LTC53_06120	COG0681	Belongs to the peptidase S26 family
LTC53_06135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LTC53_06140	COG1381	Involved in DNA repair and RecF pathway recombination
LTC53_06145	COG0745	RESPONSE REGULATOR receiver
LTC53_06155	COG2954	triphosphatase activity
LTC53_06165	COG1472	Belongs to the glycosyl hydrolase 3 family
LTC53_06170	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LTC53_06175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LTC53_06180	COG1278	Cold shock
LTC53_06185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LTC53_06195	COG1201	RNA secondary structure unwinding
LTC53_06200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LTC53_06200	COG1793	dna ligase
LTC53_06205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LTC53_06205	COG1793	dna ligase
LTC53_06235	COG0443	Heat shock 70 kDa protein
LTC53_06245	COG0183	Belongs to the thiolase family
LTC53_06275	COG1703	isobutyryl-CoA mutase activity
LTC53_06275	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LTC53_06275	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LTC53_06335	COG3250	beta-galactosidase activity
LTC53_06340	COG2186	Transcriptional regulator
LTC53_06350	COG2198	Histidine kinase
LTC53_06350	COG2205	protein histidine kinase activity
LTC53_06350	COG0784	Response regulator, receiver
LTC53_06375	COG1451	nucleotide metabolic process
LTC53_06385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LTC53_06420	COG1077	Cell shape determining protein MreB Mrl
LTC53_06425	COG1047	Peptidyl-prolyl cis-trans
LTC53_06430	COG2824	Alkylphosphonate utilization operon protein PhnA
LTC53_06435	COG1902	pentaerythritol trinitrate reductase activity
LTC53_06445	COG2814	Major facilitator Superfamily
LTC53_06475	COG0392	lysyltransferase activity
LTC53_06475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LTC53_06485	COG0251	oxidation-reduction process
LTC53_06505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LTC53_06530	COG1595	DNA-templated transcription, initiation
LTC53_06545	COG2878	Part of a membrane complex involved in electron transport
LTC53_06555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LTC53_06555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LTC53_06570	COG0346	lactoylglutathione lyase activity
LTC53_06580	COG0833	amino acid
LTC53_06585	COG2040	homocysteine
LTC53_06595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LTC53_06610	COG3118	belongs to the thioredoxin family
LTC53_06620	COG0495	leucyl-tRNA aminoacylation
LTC53_06635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LTC53_06650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LTC53_06665	COG2968	Membrane
LTC53_06685	COG0312	modulator of DNA gyrase
LTC53_06695	COG0312	modulator of DNA gyrase
LTC53_06785	COG0631	protein serine/threonine phosphatase activity
LTC53_06790	COG2815	serine threonine protein kinase
LTC53_06790	COG0515	serine threonine protein kinase
LTC53_06815	COG1858	cytochrome C peroxidase
LTC53_06825	COG0142	geranyltranstransferase activity
LTC53_06830	COG1722	exodeoxyribonuclease VII activity
LTC53_06835	COG0037	tRNA processing
LTC53_06845	COG1785	Belongs to the alkaline phosphatase family
LTC53_06850	COG1301	dicarboxylic acid transport
LTC53_06860	COG1607	acyl-coa hydrolase
LTC53_06875	COG0791	NLP P60 protein
LTC53_06880	COG0791	NLP P60 protein
LTC53_06885	COG1047	Peptidyl-prolyl cis-trans
LTC53_06890	COG2311	Membrane
LTC53_06895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LTC53_06965	COG3590	peptidase
LTC53_06980	COG0457	Tetratricopeptide repeat
LTC53_06985	COG4771	TonB-dependent receptor
LTC53_06990	COG4771	TonB-dependent receptor
LTC53_07000	COG0489	protein tyrosine kinase activity
LTC53_07005	COG0717	Belongs to the dCTP deaminase family
LTC53_07010	COG1714	RDD family
LTC53_07030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LTC53_07045	COG0494	nUDIX hydrolase
LTC53_07050	COG0433	COG0433 Predicted ATPase
LTC53_07055	COG0741	lytic transglycosylase activity
LTC53_07060	COG0688	phosphatidylethanolamine metabolic process
LTC53_07070	COG2890	protein-(glutamine-N5) methyltransferase activity
LTC53_07085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LTC53_07135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LTC53_07155	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_07175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LTC53_07185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LTC53_07190	COG0649	NAD binding
LTC53_07195	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LTC53_07200	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LTC53_07205	COG1034	ATP synthesis coupled electron transport
LTC53_07225	COG0713	ATP synthesis coupled electron transport
LTC53_07240	COG1007	ATP synthesis coupled electron transport
LTC53_07255	COG0195	Participates in both transcription termination and antitermination
LTC53_07280	COG1185	polyribonucleotide nucleotidyltransferase activity
LTC53_07285	COG3300	MHYT domain
LTC53_07285	COG5001	Diguanylate cyclase
LTC53_07305	COG0840	transmembrane signaling receptor activity
LTC53_07320	COG0835	chemotaxis
LTC53_07365	COG1194	a g-specific adenine glycosylase
LTC53_07370	COG0552	protein localization to endoplasmic reticulum
LTC53_07380	COG3938	Belongs to the proline racemase family
LTC53_07385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LTC53_07400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LTC53_07410	COG0006	proline dipeptidase activity
LTC53_07425	COG0531	amino acid
LTC53_07460	COG3507	Belongs to the glycosyl hydrolase 43 family
LTC53_07470	COG4771	TonB-dependent receptor
LTC53_07495	COG0742	ribosomal rna small subunit methyltransferase
LTC53_07510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LTC53_07515	COG0405	Gamma-glutamyltransferase
LTC53_07520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LTC53_07525	COG3291	Pkd domain containing protein
LTC53_07530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LTC53_07545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LTC53_07555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LTC53_07565	COG1862	Preprotein translocase
LTC53_07570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LTC53_07595	COG3706	GGDEF domain
LTC53_07595	COG4251	negative regulation of phosphorylation
LTC53_07595	COG5001	Diguanylate cyclase
LTC53_07595	COG2203	Gaf domain
LTC53_07600	COG1509	lysine 2,3-aminomutase activity
LTC53_07610	COG3548	integral membrane protein
LTC53_07615	COG0402	S-adenosylhomocysteine deaminase activity
LTC53_07655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LTC53_07730	COG2166	iron-sulfur cluster assembly
LTC53_07745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LTC53_07750	COG0137	argininosuccinate synthase activity
LTC53_07755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LTC53_07760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LTC53_07770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LTC53_07775	COG0165	Argininosuccinate lyase
LTC53_07795	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LTC53_07815	COG1070	Carbohydrate kinase
LTC53_07820	COG2115	Belongs to the xylose isomerase family
LTC53_07825	COG0477	Major facilitator Superfamily
LTC53_07830	COG0860	N-Acetylmuramoyl-L-alanine amidase
LTC53_07850	COG0617	tRNA 3'-terminal CCA addition
LTC53_07860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LTC53_07875	COG0166	Belongs to the GPI family
LTC53_07945	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LTC53_07960	COG0671	phosphoesterase, PA-phosphatase related
LTC53_07985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LTC53_07990	COG0167	dihydroorotate dehydrogenase activity
LTC53_08005	COG1012	belongs to the aldehyde dehydrogenase family
LTC53_08020	COG0460	homoserine dehydrogenase
LTC53_08020	COG0527	aspartate kinase activity
LTC53_08025	COG0083	homoserine kinase activity
LTC53_08030	COG2951	lytic endotransglycosylase activity
LTC53_08040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LTC53_08050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LTC53_08055	COG0124	histidyl-tRNA synthetase
LTC53_08065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LTC53_08070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LTC53_08085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LTC53_08100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LTC53_08100	COG0140	phosphoribosyl-ATP diphosphatase activity
LTC53_08120	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LTC53_08125	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LTC53_08130	COG0235	Class ii aldolase
LTC53_08135	COG0531	amino acid
LTC53_08140	COG0531	amino acid
LTC53_08155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LTC53_08160	COG0277	FAD linked oxidase domain protein
LTC53_08180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LTC53_08195	COG1024	Enoyl-CoA hydratase
LTC53_08225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LTC53_08235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LTC53_08240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LTC53_08290	COG0438	transferase activity, transferring glycosyl groups
LTC53_08295	COG0438	transferase activity, transferring glycosyl groups
LTC53_08305	COG0438	transferase activity, transferring glycosyl groups
LTC53_08330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LTC53_08340	COG1960	acyl-CoA dehydrogenase activity
LTC53_08385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LTC53_08390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LTC53_08390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LTC53_08395	COG0802	atpase or kinase
LTC53_08400	COG0860	N-Acetylmuramoyl-L-alanine amidase
LTC53_08405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LTC53_08425	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_08445	COG2081	HI0933 family
LTC53_08450	COG4681	YaeQ
LTC53_08455	COG0564	pseudouridine synthase activity
LTC53_08465	COG0625	glutathione transferase activity
LTC53_08470	COG0657	acetylesterase activity
LTC53_08475	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LTC53_08500	COG0513	Belongs to the DEAD box helicase family
LTC53_08505	COG0488	(ABC) transporter
LTC53_08520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LTC53_08530	COG1472	Belongs to the glycosyl hydrolase 3 family
LTC53_08575	COG1846	Transcriptional regulator
LTC53_08590	COG0386	Belongs to the glutathione peroxidase family
LTC53_08615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LTC53_08665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LTC53_08670	COG0084	hydrolase, TatD family'
LTC53_08685	COG1960	acyl-CoA dehydrogenase activity
LTC53_08695	COG0305	Participates in initiation and elongation during chromosome replication
LTC53_08700	COG0415	Belongs to the DNA photolyase family
LTC53_08715	COG0583	DNA-binding transcription factor activity
LTC53_08730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LTC53_08770	COG1404	Belongs to the peptidase S8 family
LTC53_08775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LTC53_08780	COG2867	negative regulation of translational initiation
LTC53_08790	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LTC53_08795	COG0735	belongs to the Fur family
LTC53_08800	COG0497	DNA recombination
LTC53_08805	COG1420	regulation of RNA biosynthetic process
LTC53_08810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LTC53_08815	COG0443	Heat shock 70 kDa protein
LTC53_08820	COG0484	heat shock protein binding
LTC53_08830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LTC53_08835	COG1605	Chorismate mutase
LTC53_08835	COG0287	Prephenate dehydrogenase
LTC53_08845	COG1132	(ABC) transporter
LTC53_08895	COG2850	peptidyl-arginine hydroxylation
LTC53_08900	COG2885	chlorophyll binding
LTC53_08945	COG1131	(ABC) transporter
LTC53_08950	COG1725	Transcriptional regulator
LTC53_08960	COG0386	Belongs to the glutathione peroxidase family
LTC53_08975	COG2900	Belongs to the SlyX family
LTC53_08985	COG2755	lipolytic protein G-D-S-L family
LTC53_08985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LTC53_08995	COG1410	methionine synthase
LTC53_08995	COG0646	methionine synthase
LTC53_09000	COG0646	methionine synthase
LTC53_09000	COG1410	methionine synthase
LTC53_09005	COG2226	methyltransferase
LTC53_09010	COG1960	acyl-CoA dehydrogenase activity
LTC53_09075	COG0577	efflux transmembrane transporter activity
LTC53_09075	COG1136	(ABC) transporter
LTC53_09105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LTC53_09105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LTC53_09110	COG1105	Belongs to the carbohydrate kinase PfkB family
LTC53_09115	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LTC53_09115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LTC53_09120	COG1609	Transcriptional regulator
LTC53_09130	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LTC53_09135	COG0069	glutamate synthase activity
LTC53_09170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LTC53_09185	COG1253	flavin adenine dinucleotide binding
LTC53_09195	COG0306	phosphate transporter
LTC53_09215	COG0504	CTP synthase activity
LTC53_09235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LTC53_09240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LTC53_09255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LTC53_09265	COG1238	metal cluster binding
LTC53_09280	COG1534	Rna-binding protein
LTC53_09285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LTC53_09290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LTC53_09295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LTC53_09300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LTC53_09310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LTC53_09315	COG1546	Belongs to the CinA family
LTC53_09320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LTC53_09325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LTC53_09330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LTC53_09335	COG2137	regulation of response to DNA damage stimulus
LTC53_09345	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LTC53_09375	COG1741	Belongs to the pirin family
LTC53_09380	COG0583	DNA-binding transcription factor activity
LTC53_09400	COG0351	phosphomethylpyrimidine kinase
LTC53_09400	COG0352	thiamine-phosphate diphosphorylase activity
LTC53_09435	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LTC53_09440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LTC53_09450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LTC53_09465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LTC53_09470	COG3734	2-keto-3-deoxy-galactonokinase
LTC53_09485	COG0800	Aldolase
LTC53_09520	COG2205	protein histidine kinase activity
LTC53_09520	COG2198	Histidine kinase
LTC53_09520	COG0784	Response regulator, receiver
LTC53_09525	COG1024	Enoyl-CoA hydratase
LTC53_09530	COG0318	PFAM AMP-dependent synthetase and ligase
LTC53_09590	COG0840	transmembrane signaling receptor activity
LTC53_09600	COG0840	transmembrane signaling receptor activity
LTC53_09610	COG0835	chemotaxis
LTC53_09625	COG0840	transmembrane signaling receptor activity
LTC53_09635	COG0840	transmembrane signaling receptor activity
LTC53_09640	COG0840	transmembrane signaling receptor activity
LTC53_09645	COG0840	transmembrane signaling receptor activity
LTC53_09655	COG0840	transmembrane signaling receptor activity
LTC53_09665	COG0840	transmembrane signaling receptor activity
LTC53_09670	COG0840	transmembrane signaling receptor activity
LTC53_09680	COG0840	transmembrane signaling receptor activity
LTC53_09685	COG0840	transmembrane signaling receptor activity
LTC53_09700	COG0745	RESPONSE REGULATOR receiver
LTC53_09710	COG0835	chemotaxis
LTC53_09715	COG1192	Involved in chromosome partitioning
LTC53_09725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LTC53_09730	COG0784	Response regulator, receiver
LTC53_09730	COG2198	Histidine kinase
LTC53_09730	COG0643	Histidine kinase
LTC53_09735	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LTC53_09785	COG1684	flagellar biosynthetic protein fliR
LTC53_09790	COG1987	bacterial-type flagellum assembly
LTC53_09800	COG3190	flagellar
LTC53_09850	COG1677	Flagellar hook-basal body complex protein FliE
LTC53_09885	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_09895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LTC53_09915	COG2201	protein-glutamate methylesterase activity
LTC53_09925	COG2197	response regulator
LTC53_09945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LTC53_09950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LTC53_09955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LTC53_09960	COG4786	Flagellar basal body rod
LTC53_09960	COG1256	bacterial-type flagellum assembly
LTC53_09960	COG4786	Flagellar basal body rod
LTC53_09960	COG1256	bacterial-type flagellum assembly
LTC53_09975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LTC53_09990	COG1749	Flagellar hook protein flgE
LTC53_10000	COG1558	bacterial-type flagellum-dependent cell motility
LTC53_10010	COG0784	Response regulator, receiver
LTC53_10010	COG0835	chemotaxis
LTC53_10070	COG2915	High frequency lysogenization protein hflD homolog
LTC53_10075	COG0482	sulfurtransferase activity
LTC53_10095	COG0542	response to heat
LTC53_10105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LTC53_10115	COG0492	ferredoxin-NADP+ reductase activity
LTC53_10120	COG1674	ftsk spoiiie
LTC53_10140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LTC53_10145	COG0038	chloride channel
LTC53_10200	COG1595	DNA-templated transcription, initiation
LTC53_10220	COG3038	cytochrome b561
LTC53_10250	COG2244	polysaccharide biosynthetic process
LTC53_10270	COG4106	trans-aconitate 2-methyltransferase activity
LTC53_10290	COG0438	transferase activity, transferring glycosyl groups
LTC53_10295	COG0438	transferase activity, transferring glycosyl groups
LTC53_10310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LTC53_10315	COG2258	MOSC domain
LTC53_10325	COG0505	Belongs to the CarA family
LTC53_10335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LTC53_10340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LTC53_10440	COG1074	ATP-dependent DNA helicase activity
LTC53_10460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LTC53_10465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LTC53_10480	COG1024	Enoyl-CoA hydratase
LTC53_10490	COG1024	Enoyl-CoA hydratase
LTC53_10495	COG1024	Enoyl-CoA hydratase
LTC53_10530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LTC53_10540	COG0346	lactoylglutathione lyase activity
LTC53_10550	COG1304	FMN binding
LTC53_10565	COG1649	PFAM Uncharacterised BCR, COG1649
LTC53_10630	COG2205	protein histidine kinase activity
LTC53_10630	COG0784	Response regulator, receiver
LTC53_10635	COG2183	response to ionizing radiation
LTC53_10640	COG4191	Histidine kinase
LTC53_10640	COG0784	Response regulator, receiver
LTC53_10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LTC53_10650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LTC53_10670	COG3243	poly(R)-hydroxyalkanoic acid synthase
LTC53_10680	COG1183	phosphatidylcholine synthase activity
LTC53_10685	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_10700	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LTC53_10710	COG0668	transmembrane transport
LTC53_10715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LTC53_10730	COG1914	H( )-stimulated, divalent metal cation uptake system
LTC53_10740	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
LTC53_10745	COG1501	Belongs to the glycosyl hydrolase 31 family
LTC53_10750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LTC53_10750	COG0519	Catalyzes the synthesis of GMP from XMP
LTC53_10760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LTC53_10775	COG0475	glutathione-regulated potassium exporter activity
LTC53_10775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LTC53_10780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LTC53_10790	COG0746	molybdenum cofactor guanylyltransferase activity
LTC53_10800	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LTC53_10810	COG1426	Protein conserved in bacteria
LTC53_10820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LTC53_10835	COG1024	Enoyl-CoA hydratase
LTC53_10835	COG1250	3-hydroxyacyl-CoA dehydrogenase
LTC53_10840	COG0183	Belongs to the thiolase family
LTC53_10845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LTC53_10855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LTC53_10860	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LTC53_10870	COG0776	regulation of translation
LTC53_10875	COG0539	negative regulation of cytoplasmic translation
LTC53_10880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LTC53_10885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LTC53_10895	COG2957	Belongs to the agmatine deiminase family
LTC53_10900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LTC53_10940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LTC53_10940	COG0316	Belongs to the HesB IscA family
LTC53_10955	COG0428	transporter
LTC53_10970	COG1530	ribonuclease E activity
LTC53_11005	COG1132	(ABC) transporter
LTC53_11045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LTC53_11055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LTC53_11060	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
LTC53_11095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LTC53_11110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LTC53_11120	COG1663	tetraacyldisaccharide 4'-kinase activity
LTC53_11125	COG1132	(ABC) transporter
LTC53_11135	COG0811	peptide transport
LTC53_11160	COG4591	ABC-type transport system involved in lipoprotein release permease component
LTC53_11185	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LTC53_11190	COG2009	succinate dehydrogenase
LTC53_11210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LTC53_11225	COG0129	dihydroxy-acid dehydratase activity
LTC53_11240	COG0395	ABC-type sugar transport system, permease component
LTC53_11275	COG2350	Protein conserved in bacteria
LTC53_11280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LTC53_11285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LTC53_11290	COG1187	pseudouridine synthase activity
LTC53_11315	COG0436	Aminotransferase
LTC53_11320	COG4133	protoheme IX ABC transporter activity
LTC53_11365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LTC53_11370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LTC53_11375	COG4988	ABC transporter
LTC53_11385	COG1294	oxidase, subunit
LTC53_11425	COG2902	Dehydrogenase
LTC53_11435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LTC53_11440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LTC53_11460	COG0556	nucleotide-excision repair
LTC53_11510	COG0583	DNA-binding transcription factor activity
LTC53_11540	COG1605	Chorismate mutase
LTC53_11540	COG0077	Prephenate dehydratase
LTC53_11545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LTC53_11550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LTC53_11590	COG4221	oxidoreductase activity
LTC53_11605	COG1228	amidohydrolase
LTC53_11620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LTC53_11635	COG1309	transcriptional regulator
LTC53_11655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LTC53_11665	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LTC53_11670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LTC53_11675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LTC53_11710	COG0316	Belongs to the HesB IscA family
LTC53_11735	COG2197	response regulator
LTC53_11780	COG0288	reversible hydration of carbon dioxide
LTC53_11795	COG3844	kynureninase activity
LTC53_11805	COG2925	Exonuclease
LTC53_11900	COG3275	phosphorelay sensor kinase activity
LTC53_11905	COG1611	Belongs to the LOG family
LTC53_11915	COG2095	MarC family integral membrane protein
LTC53_11920	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_11925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LTC53_11965	COG2969	positive regulation of protein catabolic process
LTC53_11970	COG0625	glutathione transferase activity
LTC53_11975	COG2857	Cytochrome c1
LTC53_11985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LTC53_11990	COG0723	plastoquinol--plastocyanin reductase activity
LTC53_11995	COG0741	lytic transglycosylase activity
LTC53_12010	COG1702	phosphate starvation-inducible protein PhoH
LTC53_12025	COG4535	Mg2 and Co2 transporter CorC
LTC53_12040	COG1012	belongs to the aldehyde dehydrogenase family
LTC53_12045	COG1177	transmembrane transport
LTC53_12050	COG1176	ABC-type spermidine putrescine transport system, permease component I
LTC53_12055	COG3842	ATPase activity
LTC53_12090	COG0174	glutamine synthetase
LTC53_12095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LTC53_12100	COG0174	glutamine synthetase
LTC53_12105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LTC53_12115	COG0477	Major facilitator Superfamily
LTC53_12140	COG0243	molybdopterin cofactor binding
LTC53_12150	COG2223	nitrite transmembrane transporter activity
LTC53_12175	COG1012	belongs to the aldehyde dehydrogenase family
LTC53_12180	COG1396	sequence-specific DNA binding
LTC53_12180	COG1917	Cupin 2, conserved barrel domain protein
LTC53_12185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LTC53_12190	COG0686	Belongs to the AlaDH PNT family
LTC53_12210	COG2733	membrane
LTC53_12215	COG2205	protein histidine kinase activity
LTC53_12215	COG0784	Response regulator, receiver
LTC53_12215	COG5002	protein histidine kinase activity
LTC53_12275	COG1024	Enoyl-CoA hydratase
LTC53_12285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LTC53_12290	COG0659	secondary active sulfate transmembrane transporter activity
LTC53_12310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LTC53_12315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LTC53_12325	COG0581	inorganic phosphate transmembrane transporter activity
LTC53_12335	COG0704	Plays a role in the regulation of phosphate uptake
LTC53_12355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LTC53_12375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LTC53_12385	COG0557	exoribonuclease II activity
LTC53_12420	COG2814	Major facilitator Superfamily
LTC53_12425	COG1566	PFAM secretion protein HlyD family protein
LTC53_12465	COG0367	asparagine synthase
LTC53_12475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LTC53_12485	COG1393	Belongs to the ArsC family
LTC53_12500	COG0024	Methionine aminopeptidase
LTC53_12540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LTC53_12550	COG0528	UMP kinase activity
LTC53_12560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LTC53_12565	COG0575	Belongs to the CDS family
LTC53_12570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LTC53_12575	COG0750	zinc metalloprotease
LTC53_12585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LTC53_12595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LTC53_12600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LTC53_12625	COG1981	membrane
LTC53_12695	COG1061	Type III restriction enzyme res subunit
LTC53_12740	COG1132	(ABC) transporter
LTC53_12760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LTC53_12785	COG1187	pseudouridine synthase activity
LTC53_12850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LTC53_12895	COG2080	2 iron, 2 sulfur cluster binding
LTC53_12900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LTC53_12905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LTC53_12945	COG0735	belongs to the Fur family
LTC53_12980	COG2205	protein histidine kinase activity
LTC53_12990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LTC53_13010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LTC53_13020	COG0643	Histidine kinase
LTC53_13020	COG2198	Histidine kinase
LTC53_13030	COG0840	transmembrane signaling receptor activity
LTC53_13035	COG0840	transmembrane signaling receptor activity
LTC53_13040	COG0835	chemotaxis
LTC53_13070	COG2211	Major facilitator Superfamily
LTC53_13105	COG1966	Carbon starvation protein
LTC53_13110	COG2879	small protein
LTC53_13120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LTC53_13145	COG1506	peptidase
LTC53_13145	COG0823	Involved in the tonB-independent uptake of proteins
LTC53_13150	COG1297	OPT oligopeptide transporter protein
LTC53_13155	COG3104	oligopeptide transport
LTC53_13170	COG3550	peptidyl-serine autophosphorylation
LTC53_13175	COG0629	single-stranded DNA binding
LTC53_13180	COG0142	geranyltranstransferase activity
LTC53_13205	COG0527	aspartate kinase activity
LTC53_13210	COG0384	phenazine biosynthesis protein PhzF
LTC53_13220	COG1764	response to oxidative stress
LTC53_13235	COG0739	heme binding
LTC53_13250	COG0693	protein deglycase activity
LTC53_13265	COG0719	Fe-S assembly protein
LTC53_13270	COG0396	ATPase activity
LTC53_13275	COG0719	Fe-S assembly protein
LTC53_13280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LTC53_13290	COG2146	nitrite reductase [NAD(P)H] activity
LTC53_13295	COG4774	siderophore transport
LTC53_13320	COG1477	protein flavinylation
LTC53_13325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LTC53_13345	COG1555	photosystem II stabilization
LTC53_13360	COG3178	'Phosphotransferase
LTC53_13365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LTC53_13375	COG0628	permease
LTC53_13400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LTC53_13445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LTC53_13460	COG1137	ATPase activity
LTC53_13475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LTC53_13485	COG1660	Displays ATPase and GTPase activities
LTC53_13495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LTC53_13500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LTC53_13505	COG2239	Acts as a magnesium transporter
LTC53_13525	COG1113	amino acid transport
LTC53_13535	COG0840	transmembrane signaling receptor activity
LTC53_13555	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LTC53_13570	COG0519	Catalyzes the synthesis of GMP from XMP
LTC53_13630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LTC53_13650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LTC53_13660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LTC53_13665	COG2814	Major facilitator Superfamily
LTC53_13685	COG3038	cytochrome b561
LTC53_13700	COG1760	l-serine dehydratase
LTC53_13715	COG0460	homoserine dehydrogenase
LTC53_13715	COG0527	aspartate kinase activity
LTC53_13720	COG0626	cystathionine gamma-synthase activity
LTC53_13725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LTC53_13735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LTC53_13740	COG1272	protein, Hemolysin III
LTC53_13745	COG2982	Protein involved in outer membrane biogenesis
LTC53_13750	COG0517	IMP dehydrogenase activity
LTC53_13755	COG0463	Glycosyl transferase, family 2
LTC53_13760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LTC53_13765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LTC53_13805	COG1304	FMN binding
LTC53_13815	COG1657	PFAM Prenyltransferase squalene oxidase
LTC53_13820	COG0142	geranyltranstransferase activity
LTC53_13825	COG2124	cytochrome p450
LTC53_13830	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_13835	COG1141	Ferredoxin
LTC53_13840	COG2124	cytochrome p450
LTC53_13845	COG2124	cytochrome p450
LTC53_13920	COG0330	HflC and HflK could
LTC53_13930	COG1742	UPF0060 membrane protein
LTC53_13935	COG3956	TIGRFAM MazG family protein
LTC53_13940	COG1218	3'(2'),5'-bisphosphate nucleotidase
LTC53_13945	COG0494	nUDIX hydrolase
LTC53_13955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LTC53_13965	COG0837	glucose binding
LTC53_13985	COG1388	LysM domain
LTC53_13985	COG3858	chitin binding
LTC53_13990	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LTC53_14000	COG1472	Belongs to the glycosyl hydrolase 3 family
LTC53_14020	COG3537	Alpha-1,2-mannosidase
LTC53_14295	COG4682	membrane
LTC53_14350	COG3209	COG3209 Rhs family protein
LTC53_14455	COG0521	Mo-molybdopterin cofactor biosynthetic process
LTC53_14475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LTC53_14480	COG1295	ribonuclease BN
LTC53_14510	COG1404	Belongs to the peptidase S8 family
LTC53_14515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LTC53_14555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LTC53_14575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LTC53_14575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LTC53_14630	COG4651	solute:proton antiporter activity
LTC53_14630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LTC53_14640	COG4772	TonB-dependent receptor
LTC53_14650	COG4264	IucA IucC family
LTC53_14655	COG2814	Major facilitator Superfamily
LTC53_14660	COG4264	IucA IucC family
LTC53_14665	COG0019	diaminopimelate decarboxylase activity
LTC53_14690	COG0542	response to heat
LTC53_14715	COG0454	-acetyltransferase
LTC53_14740	COG3387	PFAM Glycoside hydrolase 15-related
LTC53_14755	COG4993	Dehydrogenase
LTC53_14775	COG0564	pseudouridine synthase activity
LTC53_14780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LTC53_14790	COG1125	glycine betaine transport
LTC53_14795	COG1174	glycine betaine transport
LTC53_14810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LTC53_14820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LTC53_14820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LTC53_14835	COG4993	Dehydrogenase
LTC53_14895	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LTC53_14910	COG0745	RESPONSE REGULATOR receiver
LTC53_14920	COG0189	ligase activity
LTC53_14930	COG3511	phospholipase C
LTC53_14955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LTC53_14970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LTC53_14980	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LTC53_14985	COG0174	glutamine synthetase
LTC53_15015	COG2022	thiamine diphosphate biosynthetic process
LTC53_15025	COG0471	metal ion transport
LTC53_15025	COG3273	potassium ion transport
LTC53_15040	COG0179	Fumarylacetoacetate (FAA) hydrolase
LTC53_15055	COG1609	Transcriptional regulator
LTC53_15075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LTC53_15115	COG0840	transmembrane signaling receptor activity
LTC53_15120	COG2895	sulfate adenylyltransferase (ATP) activity
LTC53_15120	COG0529	Catalyzes the synthesis of activated sulfate
LTC53_15130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LTC53_15135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LTC53_15140	COG0175	sulfate reduction
LTC53_15170	COG1393	Belongs to the ArsC family
LTC53_15175	COG2205	protein histidine kinase activity
LTC53_15175	COG2198	Histidine kinase
LTC53_15175	COG0784	Response regulator, receiver
LTC53_15190	COG1648	precorrin-2 dehydrogenase activity
LTC53_15190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LTC53_15205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LTC53_15245	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
LTC53_15250	COG3588	fructose-bisphosphate aldolase
LTC53_15255	COG0469	pyruvate kinase activity
LTC53_15300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LTC53_15305	COG3047	cAMP biosynthetic process
LTC53_15325	COG0640	Transcriptional regulator
LTC53_15335	COG0725	ABC transporter, periplasmic molybdate-binding protein
LTC53_15340	COG4149	molybdate abc transporter
LTC53_15345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LTC53_15370	COG1376	ErfK ybiS ycfS ynhG family protein
LTC53_15375	COG0739	heme binding
LTC53_15400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LTC53_15405	COG1301	dicarboxylic acid transport
LTC53_15435	COG0714	Associated with various cellular activities
LTC53_15465	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LTC53_15485	COG0006	proline dipeptidase activity
LTC53_15490	COG3079	Belongs to the UPF0149 family
LTC53_15515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LTC53_15525	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LTC53_15545	COG1773	rubredoxin
LTC53_15560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LTC53_15585	COG2010	Cytochrome c
LTC53_15595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LTC53_15605	COG1940	carbohydrate kinase activity
LTC53_15620	COG0671	phosphoesterase, PA-phosphatase related
LTC53_15630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LTC53_15655	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LTC53_15665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LTC53_15690	COG0840	transmembrane signaling receptor activity
LTC53_15695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LTC53_15715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LTC53_15725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LTC53_15735	COG0066	3-isopropylmalate dehydratase activity
LTC53_15740	COG0473	3-isopropylmalate dehydrogenase activity
LTC53_15745	COG3706	GGDEF domain
LTC53_15755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LTC53_15760	COG1538	Outer membrane efflux protein
LTC53_15765	COG1519	Transferase
LTC53_15770	COG1560	Kdo2-lipid A biosynthetic process
LTC53_15840	COG0280	phosphate acetyltransferase
LTC53_15840	COG0281	malic enzyme
LTC53_15845	COG1301	dicarboxylic acid transport
LTC53_15855	COG4191	Histidine kinase
LTC53_15875	COG0642	Histidine kinase
LTC53_15890	COG2851	Citrate transporter
LTC53_15895	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_15905	COG2211	Major facilitator Superfamily
LTC53_15930	COG1162	GTPase activity
LTC53_15960	COG0436	Aminotransferase
LTC53_15985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LTC53_16005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LTC53_16010	COG0804	urea catabolic process
LTC53_16040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LTC53_16050	COG3791	Glutathione-dependent formaldehyde-activating
LTC53_16055	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LTC53_16070	COG2205	protein histidine kinase activity
LTC53_16140	COG0617	tRNA 3'-terminal CCA addition
LTC53_16145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LTC53_16150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LTC53_16155	COG1609	Transcriptional regulator
LTC53_16160	COG0738	Major facilitator superfamily
LTC53_16165	COG2188	Transcriptional regulator
LTC53_16180	COG3250	beta-galactosidase activity
LTC53_16215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LTC53_16225	COG4191	Histidine kinase
LTC53_16230	COG0784	Response regulator, receiver
LTC53_16235	COG2205	protein histidine kinase activity
LTC53_16235	COG2202	Pas domain
LTC53_16245	COG2823	Periplasmic or secreted lipoprotein
LTC53_16250	COG0673	inositol 2-dehydrogenase activity
LTC53_16255	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LTC53_16270	COG1090	epimerase
LTC53_16285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LTC53_16325	COG2226	methyltransferase
LTC53_16350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LTC53_16360	COG0494	nUDIX hydrolase
LTC53_16375	COG0739	heme binding
LTC53_16385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LTC53_16390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LTC53_16400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LTC53_16405	COG1181	Belongs to the D-alanine--D-alanine ligase family
LTC53_16430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LTC53_16445	COG3116	cell division
LTC53_16450	COG0275	rRNA processing
LTC53_16455	COG2001	Belongs to the MraZ family
LTC53_16490	COG0792	nuclease activity
LTC53_16500	COG0277	FAD linked oxidase domain protein
LTC53_16505	COG0745	RESPONSE REGULATOR receiver
LTC53_16510	COG2205	protein histidine kinase activity
LTC53_16520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LTC53_16525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LTC53_16550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LTC53_16555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LTC53_16560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LTC53_16575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LTC53_16575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LTC53_16585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LTC53_16615	COG0477	Major facilitator Superfamily
LTC53_16620	COG0488	(ABC) transporter
LTC53_16630	COG0242	peptide deformylase activity
LTC53_16655	COG1215	transferase activity, transferring glycosyl groups
LTC53_16665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LTC53_16720	COG2188	Transcriptional regulator
LTC53_16730	COG1450	Type ii and iii secretion system protein
LTC53_16745	COG3166	PFAM Fimbrial assembly family protein
LTC53_16750	COG3156	type II secretion system protein K
LTC53_16755	COG4795	General secretion pathway protein
LTC53_16760	COG2165	general secretion pathway protein
LTC53_16765	COG4970	Tfp pilus assembly protein FimT
LTC53_16770	COG2165	general secretion pathway protein
LTC53_16775	COG1459	type II secretion system
LTC53_16780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LTC53_16785	COG1404	Belongs to the peptidase S8 family
LTC53_16790	COG5295	Hep Hag repeat protein
LTC53_16800	COG0840	transmembrane signaling receptor activity
LTC53_16805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LTC53_16805	COG0047	phosphoribosylformylglycinamidine synthase activity
LTC53_16810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LTC53_16815	COG4974	Belongs to the 'phage' integrase family
LTC53_16840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LTC53_16845	COG2927	DNA polymerase III (CHI subunit)
LTC53_16890	COG1183	phosphatidylcholine synthase activity
LTC53_16900	COG0442	prolyl-tRNA aminoacylation
LTC53_16915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LTC53_16920	COG1127	ABC transporter
LTC53_16925	COG3218	ABC-type transport auxiliary lipoprotein component
LTC53_16925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LTC53_16955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LTC53_16960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LTC53_16965	COG0662	Cupin 2, conserved barrel domain protein
LTC53_16965	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LTC53_16990	COG2086	electron transfer activity
LTC53_17005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LTC53_17005	COG0546	phosphoglycolate phosphatase activity
LTC53_17010	COG0277	FAD linked oxidase domain protein
LTC53_17015	COG0300	oxidoreductase activity
LTC53_17035	COG0493	'glutamate synthase
LTC53_17080	COG1216	Glycosyl transferase, family 2
LTC53_17080	COG0438	transferase activity, transferring glycosyl groups
LTC53_17085	COG0438	transferase activity, transferring glycosyl groups
LTC53_17085	COG1216	Glycosyl transferase, family 2
LTC53_17090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LTC53_17105	COG0626	cystathionine gamma-synthase activity
LTC53_17135	COG0625	glutathione transferase activity
LTC53_17150	COG0720	synthase
LTC53_17160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LTC53_17165	COG1956	GAF domain-containing protein
LTC53_17175	COG4206	TonB-dependent receptor
LTC53_17180	COG0546	phosphoglycolate phosphatase activity
LTC53_17185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LTC53_17205	COG0339	signal peptide processing
LTC53_17220	COG2217	Heavy metal translocating P-type atpase
LTC53_17235	COG2132	Multicopper oxidase
LTC53_17250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LTC53_17260	COG1136	(ABC) transporter
LTC53_17265	COG1136	(ABC) transporter
LTC53_17265	COG0577	efflux transmembrane transporter activity
LTC53_17270	COG1136	(ABC) transporter
LTC53_17270	COG0577	efflux transmembrane transporter activity
LTC53_17275	COG0577	efflux transmembrane transporter activity
LTC53_17275	COG1136	(ABC) transporter
LTC53_17295	COG4191	Histidine kinase
LTC53_17305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LTC53_17320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LTC53_17335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LTC53_17345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LTC53_17355	COG0356	it plays a direct role in the translocation of protons across the membrane
LTC53_17370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LTC53_17375	COG0508	dehydrogenase complex catalyzes the overall conversion of
LTC53_17410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LTC53_17415	COG0697	spore germination
LTC53_17420	COG1666	GTP binding
LTC53_17435	COG1187	pseudouridine synthase activity
LTC53_17460	COG2205	protein histidine kinase activity
LTC53_17460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LTC53_17485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LTC53_17560	COG0842	Transport permease protein
LTC53_17565	COG1131	(ABC) transporter
LTC53_17570	COG0025	NhaP-type Na H and K H
LTC53_17580	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LTC53_17585	COG1573	uracil-dna glycosylase
LTC53_17595	COG3384	dioxygenase
LTC53_17615	COG0667	Aldo Keto reductase
LTC53_17620	COG0667	Aldo Keto reductase
LTC53_17630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LTC53_17635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LTC53_17655	COG3706	GGDEF domain
LTC53_17660	COG2146	nitrite reductase [NAD(P)H] activity
LTC53_17665	COG5001	Diguanylate cyclase
LTC53_17695	COG4106	trans-aconitate 2-methyltransferase activity
LTC53_17705	COG2076	Multidrug Resistance protein
LTC53_17715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LTC53_17735	COG3279	Response regulator of the LytR AlgR family
LTC53_17740	COG3275	phosphorelay sensor kinase activity
LTC53_17745	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LTC53_17765	COG0531	amino acid
LTC53_17775	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LTC53_17775	COG5297	Belongs to the glycosyl hydrolase family 6
LTC53_17790	COG0741	lytic transglycosylase activity
LTC53_17810	COG2207	Transcriptional regulator
LTC53_17820	COG0598	Magnesium transport protein CorA
LTC53_17825	COG1113	amino acid transport
LTC53_17830	COG0697	spore germination
LTC53_17860	COG5520	Belongs to the glycosyl hydrolase 30 family
LTC53_17945	COG0840	transmembrane signaling receptor activity
LTC53_17960	COG2353	YceI-like domain
LTC53_17990	COG0584	glycerophosphoryl diester phosphodiesterase
LTC53_18005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LTC53_18025	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LTC53_18030	COG0459	protein refolding
LTC53_18045	COG1324	tolerance protein
LTC53_18055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LTC53_18065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LTC53_18070	COG0511	ligase activity, forming carbon-carbon bonds
LTC53_18075	COG0439	Biotin carboxylase
LTC53_18090	COG2264	protein methyltransferase activity
LTC53_18110	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LTC53_18115	COG4589	Belongs to the CDS family
LTC53_18140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LTC53_18145	COG0138	bifunctional purine biosynthesis protein purh
LTC53_18150	COG0151	Belongs to the GarS family
LTC53_18155	COG1289	transmembrane transporter activity
LTC53_18160	COG2814	Major facilitator Superfamily
LTC53_18200	COG2816	NAD+ diphosphatase activity
LTC53_18240	COG2906	2 iron, 2 sulfur cluster binding
LTC53_18270	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LTC53_18285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LTC53_18290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LTC53_18295	COG0730	response to heat
LTC53_18310	COG0134	indole-3-glycerol-phosphate synthase activity
LTC53_18315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LTC53_18335	COG1597	lipid kinase activity
LTC53_18350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LTC53_18365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LTC53_18370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LTC53_18370	COG2111	Na H antiporter
LTC53_18375	COG1006	Multisubunit Na H antiporter MnhC subunit
LTC53_18380	COG0651	ATP synthesis coupled electron transport
LTC53_18385	COG1863	multisubunit Na H antiporter MnhE subunit
LTC53_18390	COG2212	antiporter activity
LTC53_18395	COG1320	monovalent cation:proton antiporter activity
LTC53_18400	COG0530	calcium, potassium:sodium antiporter activity
LTC53_18415	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LTC53_18435	COG3104	oligopeptide transport
LTC53_18440	COG3483	tryptophan 2,3-dioxygenase activity
LTC53_18455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LTC53_18470	COG0508	dehydrogenase complex catalyzes the overall conversion of
LTC53_18495	COG0513	Belongs to the DEAD box helicase family
LTC53_18520	COG2354	Protein conserved in bacteria
LTC53_18540	COG3264	Mechanosensitive ion channel
LTC53_18540	COG1196	nuclear chromosome segregation
LTC53_18545	COG3321	synthase
LTC53_18545	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_18545	COG0604	alcohol dehydrogenase
LTC53_18565	COG1595	DNA-templated transcription, initiation
LTC53_18580	COG1802	Transcriptional regulator
LTC53_18615	COG3052	prosthetic group binding
LTC53_18625	COG1414	Transcriptional regulator
LTC53_18630	COG0738	Major facilitator superfamily
LTC53_18635	COG3254	rhamnose metabolic process
LTC53_18640	COG4948	Mandelate Racemase Muconate Lactonizing
LTC53_18645	COG0179	Fumarylacetoacetate (FAA) hydrolase
LTC53_18650	COG1028	Short-chain dehydrogenase reductase Sdr
LTC53_18690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LTC53_18705	COG4807	Protein conserved in bacteria
LTC53_18745	COG1506	peptidase
LTC53_18745	COG0823	Involved in the tonB-independent uptake of proteins
LTC53_18815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LTC53_18835	COG0628	permease
LTC53_18840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LTC53_18845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LTC53_18855	COG0753	catalase activity
LTC53_18885	COG0577	efflux transmembrane transporter activity
LTC53_18905	COG0697	spore germination
LTC53_18920	COG0180	Tryptophanyl-tRNA synthetase
LTC53_18955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LTC53_18960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LTC53_18960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LTC53_18970	COG3228	Belongs to the MtfA family
LTC53_19000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LTC53_19025	COG2084	Dehydrogenase
LTC53_19030	COG1902	pentaerythritol trinitrate reductase activity
LTC53_19055	COG1404	Belongs to the peptidase S8 family
LTC53_19060	COG2814	Major facilitator Superfamily
LTC53_19065	COG0583	DNA-binding transcription factor activity
LTC53_19085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LTC53_19090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LTC53_19105	COG1764	response to oxidative stress
LTC53_19115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LTC53_19125	COG0697	spore germination
LTC53_19135	COG0523	cobalamin synthesis protein
LTC53_19145	COG1742	UPF0060 membrane protein
LTC53_19155	COG3245	cytochrome
LTC53_19165	COG1960	acyl-CoA dehydrogenase activity
LTC53_19170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LTC53_19200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LTC53_19205	COG3387	PFAM Glycoside hydrolase 15-related
LTC53_19210	COG0745	RESPONSE REGULATOR receiver
LTC53_19240	COG1404	Belongs to the peptidase S8 family
LTC53_19250	COG3100	YcgL domain-containing protein
LTC53_19255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LTC53_19265	COG0463	Glycosyl transferase, family 2
LTC53_19300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LTC53_19315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LTC53_19340	COG1294	oxidase, subunit
LTC53_19345	COG1271	oxidase subunit
LTC53_19360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LTC53_19365	COG0408	coproporphyrinogen oxidase activity
LTC53_19375	COG2323	membrane
LTC53_19380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LTC53_19380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LTC53_19400	COG0589	response to stress
LTC53_19420	COG0210	DNA helicase
LTC53_19470	COG0463	Glycosyl transferase, family 2
LTC53_19480	COG1475	DNA binding
LTC53_19485	COG1192	Involved in chromosome partitioning
LTC53_19490	COG0357	Ribosomal RNA small subunit methyltransferase G
LTC53_19505	COG2091	lysine biosynthetic process via aminoadipic acid
LTC53_19530	COG0477	Major facilitator Superfamily
LTC53_19550	COG1971	Probably functions as a manganese efflux pump
LTC53_19555	COG2205	protein histidine kinase activity
LTC53_19560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LTC53_19565	COG3459	Glycosyltransferase 36 associated
LTC53_19570	COG2211	Major facilitator Superfamily
LTC53_19575	COG3265	gluconokinase activity
LTC53_19590	COG2911	Protein conserved in bacteria
LTC53_19595	COG0729	surface antigen
LTC53_19615	COG3132	Protein of unknown function, DUF480
LTC53_19695	COG0284	orotidine-5'-phosphate decarboxylase activity
LTC53_19710	COG1609	Transcriptional regulator
LTC53_19720	COG2937	Belongs to the GPAT DAPAT family
LTC53_19745	COG2211	Major facilitator Superfamily
LTC53_19760	COG3693	PFAM glycoside hydrolase, family 10
LTC53_19780	COG3386	PFAM SMP-30 Gluconolaconase
LTC53_19800	COG0246	Mannitol dehydrogenase
LTC53_19805	COG1472	Belongs to the glycosyl hydrolase 3 family
LTC53_19815	COG4948	Mandelate Racemase Muconate Lactonizing
LTC53_19825	COG3661	Belongs to the glycosyl hydrolase 67 family
LTC53_19835	COG2115	Belongs to the xylose isomerase family
LTC53_19840	COG0037	tRNA processing
LTC53_19865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LTC53_19875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LTC53_19885	COG0805	protein transport
LTC53_19895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LTC53_19895	COG0519	Catalyzes the synthesis of GMP from XMP
LTC53_19900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LTC53_19920	COG0210	DNA helicase
LTC53_19925	COG1435	thymidine kinase activity
LTC53_19935	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LTC53_19960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LTC53_19975	COG1119	ATPase activity
LTC53_19995	COG0706	membrane insertase activity
LTC53_20000	COG0594	ribonuclease P activity