locus-tag class description F0H33_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F0H33_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) F0H33_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0H33_00025 ENOG4108TYN CAAX amino terminal protease family protein F0H33_00030 ENOG4108K0D peptidase, M48 F0H33_00065 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) F0H33_00075 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F0H33_00095 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 F0H33_00100 ENOG4105CGF Aromatic amino acid aminotransferase F0H33_00105 ENOG4105CHB tonB-dependent Receptor F0H33_00115 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F0H33_00120 ENOG4105C26 Dehydrogenase F0H33_00150 ENOG4105DQE DNA ligase F0H33_00155 ENOG4105DMF Dehydrogenase F0H33_00175 ENOG4105RKW reductase (By F0H33_00185 ENOG4105D7K pfkb domain protein F0H33_00280 ENOG4105WPN DNA integration recombination invertion protein F0H33_00300 ENOG4107ZSV Receptor F0H33_00340 ENOG4105EBR Carboxylesterase F0H33_00355 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit F0H33_00365 ENOG4105CG6 trap dicarboxylate transporter dctm subunit F0H33_00370 ENOG4105DSG hydrolase family 43 F0H33_00375 ENOG4105ETE Transcriptional regulator (LacI family F0H33_00380 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) F0H33_00385 ENOG4105CHR reductase F0H33_00400 ENOG4105MIR Phenylalanine 4-monooxygenase F0H33_00405 ENOG4108YXU transcriptional regulator AsnC family F0H33_00420 ENOG4105D78 K07001 NTE family protein F0H33_00450 ENOG4105DU1 integral membrane protein, terc F0H33_00455 ENOG4105DR4 Methyltransferase F0H33_00490 ENOG4105BZW Glycerate kinase F0H33_00495 ENOG4105NRM Membrane F0H33_00500 ENOG4105CUB amino acid F0H33_00505 ENOG4108ZXC Two component transcriptional regulator, luxr family F0H33_00510 ENOG4105BZU Histidine kinase F0H33_00530 ENOG4107QSV RmuC domain protein F0H33_00535 ENOG4108V06 Glutathione peroxidase F0H33_00540 ENOG410903C (LipO)protein F0H33_00555 ENOG4107PE3 Mammalian cell entry related domain protein F0H33_00560 ENOG4105CY3 ABC transporter, permease F0H33_00565 ENOG4105DHJ ABC, transporter F0H33_00570 ENOG4105DSY exodeoxyribonuclease V, gamma F0H33_00575 ENOG4107QKA exodeoxyribonuclease V beta F0H33_00580 ENOG4107QYX exodeoxyribonuclease v alpha F0H33_00670 ENOG4105CSH Transporter F0H33_00675 ENOG4105EUJ GTP cyclohydrolase i F0H33_00700 ENOG4105EJ9 Membrane F0H33_00705 ENOG4105K5B UPF0225 protein F0H33_00715 ENOG4105CVE Lytic murein transglycosylase F0H33_00770 ENOG4108Z5K methylglyoxal synthase F0H33_00795 ENOG4105BZ8 glutamate synthase F0H33_00800 ENOG4105CBC glutamate synthase F0H33_00845 ENOG4108I5C dEAD DEAH box helicase F0H33_00850 ENOG4105VDM plasmid maintenance system antidote protein, xre family F0H33_00880 ENOG4105C54 Major Facilitator superfamily F0H33_00930 ENOG4107QJE Chromosome Partitioning Protein F0H33_00935 ENOG4105M4E phosphohistidine phosphatase, SixA F0H33_00945 ENOG4107RZC phospholipase d F0H33_00950 ENOG4105KA0 thioesterase Superfamily protein F0H33_00960 ENOG4105E5G Alpha beta hydrolase fold F0H33_00980 ENOG4108V1U phospholipid-binding protein F0H33_00985 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F0H33_00990 ENOG4105C5F glutamine synthetase F0H33_01000 ENOG4105BZU Histidine kinase F0H33_01005 ENOG4105CUX Signal transduction histidine kinase F0H33_01010 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0H33_01015 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0H33_01020 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0H33_01030 ENOG4105CHU acetyl-coa acetyltransferase F0H33_01070 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) F0H33_01075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase F0H33_01085 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F0H33_01105 ENOG4105E2T synthase III F0H33_01110 ENOG4107R3N Filamentation induced by cAMP protein fic F0H33_01115 ENOG4108J2P Alpha beta hydrolase fold F0H33_01125 ENOG4105PI0 Ferredoxin F0H33_01130 ENOG410680H amp-dependent synthetase and ligase F0H33_01140 ENOG4107S1E Beta-lactamase F0H33_01145 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F0H33_01155 ENOG4105CPF Cell wall formation (By similarity) F0H33_01165 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F0H33_01170 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) F0H33_01175 ENOG4105DR9 pseudouridine synthase F0H33_01185 ENOG4108YZN class I peptide chain release factor F0H33_01195 ENOG4105DGW oligopeptidase A F0H33_01220 ENOG4105DUM transcriptional regulator, lysR family F0H33_01225 ENOG4107QP3 malate synthase g F0H33_01235 ENOG4105BZU Histidine kinase F0H33_01265 ENOG4105CHH sulfate transporter F0H33_01305 ENOG4105F2Z 3-oxoadipate enol-lactonase F0H33_01310 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein F0H33_01325 ENOG4108R99 pseudouridine synthase F0H33_01345 ENOG4105F8V Hydrolase, tatD family F0H33_01360 ENOG4105E3A (ABC) transporter F0H33_01365 ENOG4105DA5 (ABC) transporter F0H33_01370 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein F0H33_01380 ENOG4105VZ8 Transcriptional regulator F0H33_01390 ENOG4108IUW ABC transporter F0H33_01405 ENOG4108TEB UPF0114 protein F0H33_01410 ENOG4105CYM Glutathione S-transferase F0H33_01450 ENOG4105D52 delta-aminolevulinic acid dehydratase F0H33_01475 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F0H33_01495 ENOG4105DVT helicase F0H33_01510 ENOG4105CH6 catalase F0H33_01560 ENOG4105C8Y Acetylornithine aminotransferase F0H33_01580 ENOG4105C02 permease F0H33_01595 ENOG4105D8V Glucose sorbosone dehydrogenase F0H33_01635 ENOG4106032 Glutathionylspermidine synthase F0H33_01645 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0H33_01680 ENOG4105D2S major facilitator superfamily F0H33_01690 ENOG4108Z0R Transferase F0H33_01705 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0H33_01710 ENOG4105BZS acriflavin resistance protein F0H33_01720 ENOG4105BZU Histidine kinase F0H33_01760 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) F0H33_01765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0H33_01770 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) F0H33_01780 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F0H33_01785 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) F0H33_01810 ENOG4105C0P Mg chelatase subunit ChlI F0H33_01815 ENOG4105W0Z cytoplasmic protein F0H33_01820 ENOG4108YZA Nitrogen regulatory protein pii F0H33_01835 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) F0H33_01840 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) F0H33_01845 ENOG4105CEY Amp-dependent synthetase and ligase F0H33_01855 ENOG4105EXC Acyl-transferase F0H33_01880 ENOG4105EMU Dehydrogenase F0H33_01890 ENOG4105C75 arginyL-tRNA synthetase F0H33_01895 ENOG4105W5Q DNA repair protein (RadC F0H33_01900 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F0H33_01920 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) F0H33_01930 ENOG4105EYM Major Facilitator superfamily F0H33_01940 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F0H33_01945 ENOG4105DR5 peptidase F0H33_01950 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F0H33_01980 ENOG4105DQ4 alcohol dehydrogenase F0H33_01985 ENOG4107VAM peptidase, m28 F0H33_01995 ENOG41063SB peptidase F0H33_02000 ENOG4105CN1 protease F0H33_02015 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation F0H33_02030 ENOG4107QHQ amino acid F0H33_02035 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) F0H33_02040 ENOG4105C26 Dehydrogenase F0H33_02050 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) F0H33_02055 ENOG4105BZ9 Cytochrome C oxidase, subunit I F0H33_02060 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) F0H33_02065 ENOG4107QS1 Cytochrome C Oxidase, Subunit III F0H33_02095 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) F0H33_02105 ENOG4105DHU Bile acid F0H33_02110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F0H33_02115 ENOG4107S2Z UPF0761 membrane protein F0H33_02125 ENOG4105VCC 30S ribosomal protein S21 F0H33_02130 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F0H33_02135 ENOG4107ZVW dihydroneopterin aldolase F0H33_02150 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F0H33_02175 ENOG4105D5Q Arginine ornithine antiporter F0H33_02185 ENOG4105DTQ mandelate racemase muconate lactonizing F0H33_02195 ENOG4105D05 Receptor F0H33_02200 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase F0H33_02250 ENOG4105E32 cytoplasmic protein F0H33_02260 ENOG4105BZS acriflavin resistance protein F0H33_02265 ENOG4105BZS acriflavin resistance protein F0H33_02270 ENOG4105ENT Efflux transporter rnd family, mfp subunit F0H33_02280 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) F0H33_02295 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) F0H33_02300 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) F0H33_02320 ENOG4105FB9 CRISPR-associated protein F0H33_02330 ENOG4105E9K Isocitrate dehydrogenase F0H33_02340 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0H33_02345 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) F0H33_02355 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F0H33_02360 ENOG4105K63 Thioredoxin F0H33_02365 ENOG4105C1J atp-dependent rna helicase F0H33_02370 ENOG4105CAK Cell division ATP-binding protein ftsE F0H33_02375 ENOG4105CRP Part of the ABC transporter FtsEX involved in F0H33_02380 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase F0H33_02385 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) F0H33_02390 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0H33_02395 ENOG4105EN6 Membrane F0H33_02410 ENOG4105C25 Primosomal protein n' F0H33_02420 ENOG4107QI1 Mate efflux family protein F0H33_02425 ENOG4105D07 Signal peptide peptidase, SppA F0H33_02435 ENOG4105CHR reductase F0H33_02450 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F0H33_02455 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F0H33_02470 ENOG4108RPN Protein smg homolog F0H33_02475 ENOG4105C79 DNA protecting protein DprA F0H33_02480 ENOG4108WZM domain protein F0H33_02485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F0H33_02490 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F0H33_02495 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F0H33_02500 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) F0H33_02515 ENOG4106WTF Glycosyl transferase, family 2 F0H33_02535 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) F0H33_02540 ENOG4108Z7F N-acetyltransferase F0H33_02550 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) F0H33_02555 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0H33_02590 ENOG4107P2S Transcriptional regulator F0H33_02600 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) F0H33_02605 ENOG4105CG3 alpha amylase, catalytic region F0H33_02655 ENOG4107Z3H Transcriptional regulator, TetR family F0H33_02690 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_02705 ENOG4105WEF catalase F0H33_02710 ENOG4108Z9Z response to DNA damage stimulus F0H33_02715 ENOG4108N8X transition metal ion binding F0H33_02725 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F0H33_02730 ENOG4105BZU Histidine kinase F0H33_02735 ENOG4105EHU Circadian clock protein KaiC F0H33_02745 ENOG4105EJ2 Transcriptional regulator F0H33_02750 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F0H33_02765 ENOG4105C7K acetolactate synthase F0H33_02770 ENOG4105BZU Histidine kinase F0H33_02775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0H33_02800 ENOG4105DZR Type I site-specific deoxyribonuclease F0H33_02815 ENOG4105F5P DNA-damage-inducible protein d F0H33_02835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0H33_02840 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) F0H33_02845 ENOG4105D7T ABC transporter F0H33_02855 ENOG4108IFG nitrite reductase, (NAD(P)H) F0H33_02860 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit F0H33_02870 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0H33_02890 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) F0H33_02895 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F0H33_02900 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F0H33_02905 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) F0H33_02915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0H33_02925 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) F0H33_02935 ENOG4108NEV two component transcriptional regulator, LytTR family F0H33_02940 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) F0H33_02955 ENOG4105KVH Transcriptional regulator F0H33_02995 ENOG4105WD1 Membrane F0H33_03005 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) F0H33_03015 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F0H33_03020 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) F0H33_03025 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) F0H33_03050 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F0H33_03055 ENOG4105CD8 aminopeptidase N F0H33_03060 ENOG4107TTQ Alpha beta hydrolase fold F0H33_03085 ENOG4105DFF Rod shape-determining protein mreb F0H33_03090 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) F0H33_03100 ENOG4105CJN penicillin-binding protein F0H33_03105 ENOG4105CNI cell division protein FtsW F0H33_03120 ENOG4105CVE Lytic murein transglycosylase F0H33_03130 ENOG4105DZ1 carboxypeptidase F0H33_03160 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F0H33_03165 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) F0H33_03170 ENOG4105CN1 protease F0H33_03230 ENOG4105CSA Coproporphyrinogen iii oxidase F0H33_03235 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F0H33_03240 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) F0H33_03245 ENOG4105DSJ YicC domain protein F0H33_03250 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) F0H33_03255 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) F0H33_03260 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F0H33_03275 ENOG4105KME endoribonuclease L-psp F0H33_03280 ENOG4105CB5 ATP-dependent DNA helicase recG F0H33_03290 ENOG4105NRA 50s ribosomal protein l31 type b F0H33_03295 ENOG4105BZN citrate synthase F0H33_03310 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F0H33_03330 ENOG4105D9N nucleoside F0H33_03335 ENOG4105CPC Aldo Keto reductase F0H33_03345 ENOG4105D05 Receptor F0H33_03365 ENOG4105CV6 ABC transporter, permease F0H33_03370 ENOG4108I0Y (ABC) transporter F0H33_03375 ENOG4108UJV acyl-CoA thioesterase i F0H33_03380 ENOG4105ETX regulatoR F0H33_03385 ENOG4105DHQ Histidine kinase F0H33_03395 ENOG41080IJ Diacylglycerol kinase F0H33_03400 ENOG4105EE5 Membrane protein terC F0H33_03405 ENOG4108V0P LemA family F0H33_03420 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) F0H33_03425 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) F0H33_03435 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F0H33_03440 ENOG4105NWN ApaG protein F0H33_03445 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F0H33_03450 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) F0H33_03455 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) F0H33_03460 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) F0H33_03465 ENOG4105DGU Histone deacetylase F0H33_03470 ENOG4108WBT adenosyltransferase F0H33_03480 ENOG4105D0A hydroxylase F0H33_03485 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family F0H33_03510 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) F0H33_03530 ENOG4105DXC membrane F0H33_03535 ENOG4105CX6 glutaminyL-tRNA synthetase F0H33_03560 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) F0H33_03565 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F0H33_03570 ENOG4105NXH GreA GreB family elongation factor F0H33_03580 ENOG4105C5Q Transcriptional regulator F0H33_03610 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0H33_03615 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0H33_03620 ENOG4105C5H ABC transporter F0H33_03630 ENOG4105ETT transcriptional Regulator, LysR family F0H33_03645 ENOG4105HSS phospholipase C F0H33_03665 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) F0H33_03675 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein F0H33_03685 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) F0H33_03695 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F0H33_03705 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F0H33_03710 ENOG4105C3G gtp-binding protein F0H33_03730 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F0H33_03740 ENOG4105PM1 preprotein translocase subunit SecE F0H33_03745 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F0H33_03750 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) F0H33_03755 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) F0H33_03765 ENOG4108VZM 50s ribosomal protein L10 F0H33_03770 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) F0H33_03780 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F0H33_03785 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) F0H33_03790 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) F0H33_03795 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) F0H33_03800 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) F0H33_03805 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) F0H33_03810 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) F0H33_03820 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) F0H33_03825 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity F0H33_03830 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) F0H33_03835 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) F0H33_03845 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) F0H33_03855 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal F0H33_03860 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) F0H33_03865 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) F0H33_03870 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits F0H33_03875 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) F0H33_03885 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) F0H33_03890 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) F0H33_03895 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) F0H33_03900 ENOG41087MT 50S ribosomal protein L30 F0H33_03905 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) F0H33_03910 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F0H33_03915 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits F0H33_03920 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) F0H33_03925 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) F0H33_03930 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F0H33_03935 ENOG4108ZT0 50S ribosomal protein l17 F0H33_03940 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) F0H33_03950 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase F0H33_03965 ENOG4105CI3 gtp-binding protein typa F0H33_03970 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) F0H33_03980 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F0H33_03995 ENOG4108K3A Glutathione S-transferase F0H33_04045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0H33_04055 ENOG4105CPC Aldo Keto reductase F0H33_04075 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 F0H33_04085 ENOG4108R99 pseudouridine synthase F0H33_04090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0H33_04095 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F0H33_04100 ENOG4108I5D sulfate abc transporter F0H33_04110 ENOG4108IJ6 ABC transporter F0H33_04120 ENOG4105CPQ Dehydrogenase F0H33_04130 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F0H33_04135 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F0H33_04150 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase F0H33_04155 ENOG4105ED9 Protein of unknown function (DUF455) F0H33_04160 ENOG4108YP4 Metalloprotease, specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues (By similarity) F0H33_04170 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) F0H33_04180 ENOG4105BZF Glycosyl transferase (Group 1 F0H33_04190 ENOG4105C9X ppx gppa phosphatase F0H33_04195 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F0H33_04200 ENOG4105BZU Histidine kinase F0H33_04205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0H33_04210 ENOG4105ERG peptidase m48, ste24p F0H33_04215 ENOG4105VW4 glutaredoxin 3 F0H33_04225 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F0H33_04260 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation F0H33_04265 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F0H33_04270 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) F0H33_04300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F0H33_04305 ENOG41068JE domain protein F0H33_04310 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F0H33_04320 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F0H33_04325 ENOG4107RZZ dna polymerase iii epsilon subunit F0H33_04330 ENOG4108ZF3 Phosphatase F0H33_04350 ENOG4105DKP glycosyl transferase, family 9 F0H33_04355 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) F0H33_04360 ENOG4107UV6 ribonuclease Z F0H33_04365 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F0H33_04380 ENOG4105M00 molybdopterin converting factor, subunit 1 F0H33_04385 ENOG4108ZAF Molybdopterin F0H33_04410 ENOG4107QMP dna polymerase iii subunits gamma and tau F0H33_04415 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) F0H33_04425 ENOG4105K59 histidine triad (HIT) protein F0H33_04435 ENOG4105F8C transglutaminase domain-containing protein F0H33_04445 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0H33_04455 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 F0H33_04470 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein F0H33_04475 ENOG4105VGS 50s ribosomal protein l32 F0H33_04480 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F0H33_04485 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F0H33_04490 ENOG4105CHR reductase F0H33_04500 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0H33_04505 ENOG4105CRQ synthase (Component I) F0H33_04510 ENOG4105HHA aminodeoxychorismate lyase F0H33_04515 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) F0H33_04520 ENOG4107QRG dna polymerase iii F0H33_04535 ENOG4105KRQ Addiction module toxin, Txe YoeB family F0H33_04540 ENOG4105VTW prevent-host-death family F0H33_04575 ENOG4105C0B DNA polymerase III (alpha subunit) F0H33_04590 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) F0H33_04595 ENOG4105BZN citrate synthase F0H33_04600 ENOG4105CR4 methylisocitrate lyase F0H33_04605 ENOG4105BZN citrate synthase F0H33_04610 ENOG4108I0Z Aconitate hydratase F0H33_04620 ENOG4105C7F AcnD-accessory protein PrpF F0H33_04655 ENOG4105DN3 alpha-2-macroglobulin domain protein F0H33_04675 ENOG4108JQB penicillin-binding protein 1C F0H33_04705 ENOG4105M3Z response regulator F0H33_04715 ENOG4107QJR hflk protein F0H33_04720 ENOG4105EPW hflc protein F0H33_04800 ENOG4105E2A Dehydrogenase F0H33_04810 ENOG4108TN2 lmbE family F0H33_04835 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor F0H33_04850 ENOG4108JJA ABC, transporter F0H33_04855 ENOG4105C2C drug resistance transporter, Bcr CflA F0H33_04875 ENOG4105DIJ Phosphoethanolamine transferase F0H33_04885 ENOG4105ETX regulatoR F0H33_04890 ENOG4105C08 Histidine kinase F0H33_04900 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) F0H33_04905 ENOG4107QMS site-determining protein F0H33_04910 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) F0H33_04920 ENOG4105BZU Histidine kinase F0H33_04950 ENOG4105K64 Glycosyl transferase, family 2 F0H33_04955 ENOG4105BZ4 penicillin-binding protein F0H33_04965 ENOG4105DVT helicase F0H33_04970 ENOG41072GX Peptidase M22 Glycoprotease F0H33_04985 ENOG4105D7Z glutathione synthase F0H33_04990 ENOG4108UNF response regulator F0H33_04995 ENOG4105M3Z response regulator F0H33_05000 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis F0H33_05005 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_05010 ENOG4105CBS Chea signal transduction histidine kinase F0H33_05015 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) F0H33_05055 ENOG4106N3A copper homeostasis protein cutc F0H33_05075 ENOG4105C9M aspartyl-trna synthetase F0H33_05095 ENOG4105CDY transcriptional regulatory protein F0H33_05100 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) F0H33_05105 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) F0H33_05110 ENOG4105DFH Transport of potassium into the cell (By similarity) F0H33_05120 ENOG4107YD3 Thioesterase F0H33_05125 ENOG4105E02 MotA TolQ exbB proton channel F0H33_05130 ENOG4105M8F Biopolymer transport protein exbD tolR F0H33_05140 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) F0H33_05145 ENOG4105KCK Peptidoglycan-associated lipoprotein F0H33_05155 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F0H33_05180 ENOG4105C9U ATP-dependent DNA helicase RecQ F0H33_05190 ENOG4105CQ7 ATP-dependent helicase F0H33_05205 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E F0H33_05220 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) F0H33_05235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F0H33_05285 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR F0H33_05295 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate F0H33_05300 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F0H33_05310 ENOG4105C29 acyl-CoA thioesterase F0H33_05315 ENOG4105E39 Enoyl-CoA hydratase F0H33_05325 ENOG4108TGP Thioesterase superfamily protein F0H33_05330 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F0H33_05335 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) F0H33_05350 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control F0H33_05355 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) F0H33_05360 ENOG4105CJR Integral membrane protein (MviN F0H33_05385 ENOG4105DTN riboflavin biosynthesis protein ribF F0H33_05390 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F0H33_05395 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) F0H33_05400 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) F0H33_05415 ENOG4105E2S oxidase) subunit II F0H33_05420 ENOG4105BZ9 Cytochrome C oxidase, subunit I F0H33_05425 ENOG4105CCU oxidase (Subunit III) F0H33_05430 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) F0H33_05440 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0H33_05445 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F0H33_05450 ENOG4105KAF membrAne F0H33_05530 ENOG4108HR8 type iii secretion F0H33_05550 ENOG4107Y59 type iii secretion F0H33_05565 ENOG4108JIR Flagellum-specific ATP synthase F0H33_05585 ENOG4105K44 type iii secretion F0H33_05600 ENOG4105FTC Lytic transglycosylase catalytic F0H33_05605 ENOG4105C01 Dihydroxy-acid dehydratase F0H33_05625 ENOG4105C26 Dehydrogenase F0H33_05630 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator F0H33_05635 ENOG4105C2J ABC transporter F0H33_05640 ENOG4107R9N ABC transporter F0H33_05645 ENOG41062B0 ABC transporter, permease F0H33_05655 ENOG4105CGS Alpha-glucosidase F0H33_05660 ENOG4108TGY Glutathione S-transferase F0H33_05680 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) F0H33_05685 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) F0H33_05695 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY F0H33_05700 ENOG4105EA8 2-Nitropropane dioxygenase F0H33_05710 ENOG4105K5M 30s ribosomal protein S16 F0H33_05715 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) F0H33_05720 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) F0H33_05725 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) F0H33_05730 ENOG4107QJQ Mate efflux family protein F0H33_05740 ENOG4105VEJ Heat shock protein F0H33_05745 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) F0H33_05760 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) F0H33_05775 ENOG4105HMI Membrane F0H33_05795 ENOG4105EMN RNA polymerase sigma factor F0H33_05805 ENOG4105C0H protease F0H33_05815 ENOG4105C3F Signal peptidase i F0H33_05825 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) F0H33_05830 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F0H33_05845 ENOG4105EFQ Two component transcriptional regulator (Winged helix family F0H33_05850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F0H33_05855 ENOG41080ZE Adenylate cyclase F0H33_05865 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) F0H33_05870 ENOG4108UGV hypoxanthine phosphoribosyltransferase F0H33_05875 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) F0H33_05880 ENOG4105VEQ Cold shock protein F0H33_05885 ENOG41061H0 Monooxygenase F0H33_05895 ENOG4107QRT dEAD DEAH box helicase F0H33_05900 ENOG4107T0X DNA ligase F0H33_05905 ENOG4107T0X DNA ligase F0H33_05920 ENOG4105BZU Histidine kinase F0H33_05935 ENOG4105F7F Chaperone F0H33_05945 ENOG4105CHU acetyl-coa acetyltransferase F0H33_05975 ENOG4105D5P Methylmalonyl-coA mutase F0H33_06005 ENOG4108MHS Lysyl endopeptidase F0H33_06030 ENOG4105CNT hydrolase family 2 F0H33_06035 ENOG4107EJG GntR family transcriptional regulator F0H33_06045 ENOG4105BZU Histidine kinase F0H33_06070 ENOG4108VKG metal-dependent hydrolase F0H33_06080 ENOG4105KSC Transcriptional regulator, TraR DksA family F0H33_06110 ENOG4108MIC Mg-protoporphyrin IX methyl transferase F0H33_06120 ENOG4108YZY peptidylprolyl cis-trans isomerase F0H33_06125 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F0H33_06130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0H33_06135 ENOG4105F27 Major Facilitator F0H33_06175 ENOG4105M4H endoribonuclease L-psp F0H33_06200 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F0H33_06225 ENOG4105K6V RNA polymerase F0H33_06240 ENOG4108R3D Electron transport complex F0H33_06265 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F0H33_06275 ENOG4108IQI permease F0H33_06280 ENOG4107QK5 Homocysteine s-methyltransferase F0H33_06310 ENOG4105K63 Thioredoxin F0H33_06320 ENOG4105C8T Leucyl-tRNA synthetase F0H33_06335 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) F0H33_06365 ENOG4105MPN Membrane F0H33_06370 ENOG4108Z03 MAF-like protein F0H33_06375 ENOG4105C03 ribonuclease F0H33_06385 ENOG4105D1U peptidase U62 modulator of DNA gyrase F0H33_06390 ENOG4105N42 UPF0307 protein F0H33_06395 ENOG4105CMS peptidase U62, modulator of DNA gyrase F0H33_06415 ENOG4108WC9 type VI secretion system effector, hcp1 family F0H33_06440 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0H33_06455 ENOG4105CS6 Rhs element vgr protein F0H33_06490 ENOG4108ZF3 Phosphatase F0H33_06495 ENOG4105D9P serine threonine protein kinase F0H33_06520 ENOG4105CA0 peroxidase F0H33_06530 ENOG4105CTB Polyprenyl synthetase F0H33_06535 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) F0H33_06540 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F0H33_06550 ENOG4105G6Z alkaline phosphatase F0H33_06555 ENOG4105CK2 sodium dicarboxylate symporter F0H33_06580 ENOG4105K4H Nlp p60 protein F0H33_06585 ENOG4105K4H Nlp p60 protein F0H33_06590 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase F0H33_06600 ENOG4105MWK D-amino acid dehydrogenase, small subunit F0H33_06610 ENOG41075CH type III effector F0H33_06615 ENOG41075CH type III effector F0H33_06620 ENOG4108UZ3 Transporter F0H33_06650 ENOG4105C9K Endothelin-converting enzyme 1 F0H33_06665 ENOG4107RDJ Sulfotransferase F0H33_06670 ENOG4105D05 Receptor F0H33_06675 ENOG4105D05 Receptor F0H33_06690 ENOG4105DHP deoxycytidine triphosphate deaminase F0H33_06715 ENOG4108RRZ Transcription elongation factor GreB F0H33_06730 ENOG4107VIJ nudix hydrolase F0H33_06735 ENOG4105D7A ATP-binding protein F0H33_06740 ENOG4106770 Is able to cleave peptidoglycan (By similarity) F0H33_06745 ENOG4105DJ4 phosphatidylserine decarboxylase F0H33_06755 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) F0H33_06760 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F0H33_06770 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F0H33_06780 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F0H33_06785 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase F0H33_06800 ENOG4108MGI Transcriptional regulator F0H33_06805 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F0H33_06820 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) F0H33_06825 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) F0H33_06845 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr F0H33_06850 ENOG4105CP7 Triose-phosphate isomerase F0H33_06865 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F0H33_06870 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0H33_06875 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F0H33_06885 ENOG4105GKE subunit e F0H33_06890 ENOG4107QIZ NADH dehydrogenase F0H33_06895 ENOG4108IEH NADH dehydrogenase subunit g F0H33_06900 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) F0H33_06905 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0H33_06910 ENOG4105DF2 NADH dehydrogenase subunit j F0H33_06915 ENOG41080FQ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0H33_06920 ENOG4105D65 subunit l F0H33_06925 ENOG4105C8S subunit m F0H33_06930 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0H33_06945 ENOG4105CHV Transcription elongation factor NusA F0H33_06950 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) F0H33_06965 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) F0H33_06970 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) F0H33_06975 ENOG4105BZU Histidine kinase F0H33_06995 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_07000 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_07005 ENOG4108V3W Chemotaxis protein, CheW F0H33_07045 ENOG4105DFP Integrase F0H33_07085 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) F0H33_07090 ENOG4105CEN a g-specific adenine glycosylase F0H33_07095 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F0H33_07105 ENOG4105CTU Proline racemase F0H33_07110 ENOG41080HI glycine oxidase F0H33_07125 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F0H33_07135 ENOG4105DC7 peptidase M24 F0H33_07150 ENOG4107QTZ amino acid F0H33_07175 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0H33_07195 ENOG4105D05 Receptor F0H33_07210 ENOG4105DG4 malate L-lactate dehydrogenase F0H33_07215 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) F0H33_07220 ENOG4106H78 methyltransferase F0H33_07235 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding F0H33_07240 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) F0H33_07245 ENOG4105C8F Beta-lactamase domain protein F0H33_07250 ENOG4105E08 Glycoside hydrolase, family 9 F0H33_07255 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) F0H33_07270 ENOG4105C8Y Acetylornithine aminotransferase F0H33_07280 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) F0H33_07290 ENOG4105VIE preprotein translocase, subunit YajC F0H33_07295 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F0H33_07300 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F0H33_07325 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F0H33_07340 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) F0H33_07345 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F0H33_07350 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F0H33_07380 ENOG4105CD3 dihydroorotase F0H33_07385 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) F0H33_07390 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters F0H33_07450 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) F0H33_07455 ENOG4105C8N cysteinyl-tRNA synthetase F0H33_07465 ENOG4105DBV ornithine carbamoyltransferase F0H33_07470 ENOG4105CDH Citrulline--aspartate ligase F0H33_07480 ENOG4105CAS nag kinase F0H33_07490 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase F0H33_07495 ENOG4105CH7 arginosuccinase F0H33_07510 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) F0H33_07515 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) F0H33_07535 ENOG4105CMG Carbohydrate kinase F0H33_07540 ENOG4105C93 Xylose Isomerase F0H33_07550 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F0H33_07555 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) F0H33_07570 ENOG4105DJ0 Poly(A) Polymerase F0H33_07580 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) F0H33_07585 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) F0H33_07595 ENOG4107QP8 phosphohexose isomerase F0H33_07635 ENOG4105CS6 Rhs element vgr protein F0H33_07640 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F0H33_07650 ENOG4105BZU Histidine kinase F0H33_07665 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) F0H33_07670 ENOG410841Q phosphoesterase PA-phosphatase related protein F0H33_07695 ENOG4105D4A Cell wall formation (By similarity) F0H33_07700 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) F0H33_07715 ENOG4105C26 Dehydrogenase F0H33_07730 ENOG4105CFH Aspartokinase F0H33_07740 ENOG4105CVE Lytic murein transglycosylase F0H33_07745 ENOG4105R0I Feruloyl esterase F0H33_07750 ENOG4105D98 threonine synthase F0H33_07760 ENOG4105DS0 Transcriptional regulator, Crp Fnr family F0H33_07775 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F0H33_07780 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F0H33_07785 ENOG4105CIH Imidazole acetol-phosphate transaminase F0H33_07795 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F0H33_07800 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase F0H33_07805 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) F0H33_07810 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase F0H33_07830 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) F0H33_07835 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) F0H33_07840 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) F0H33_07845 ENOG4105CUB amino acid F0H33_07850 ENOG4105CUB amino acid F0H33_07865 ENOG4108JQ1 Dehydrogenase F0H33_07870 ENOG4105CQB FAD linked oxidase domain protein F0H33_07890 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) F0H33_07900 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase F0H33_07905 ENOG4105E39 Enoyl-CoA hydratase F0H33_07915 ENOG4105CE1 Ferrous iron transport protein b F0H33_07930 ENOG4105C22 threonyL-tRNA synthetase F0H33_07935 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F0H33_07940 ENOG41082NX 50s ribosomal protein l35 F0H33_07945 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) F0H33_07950 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) F0H33_07955 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F0H33_07960 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) F0H33_07965 ENOG4105WJX transcriptional regulator MERR family F0H33_07985 ENOG4105D3Q Sugar transferase F0H33_08005 ENOG4107Y2G Glycosyl transferase (Group 1 F0H33_08015 ENOG4108NQK Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a F0H33_08040 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) F0H33_08050 ENOG4105CSU acyl-Coa dehydrogenase F0H33_08085 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) F0H33_08090 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F0H33_08095 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) F0H33_08100 ENOG4105K8N protein family UPF0079, ATPase F0H33_08105 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F0H33_08110 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) F0H33_08130 ENOG4105CHR reductase F0H33_08135 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) F0H33_08140 ENOG4105D0M Protease HtpX homolog F0H33_08150 ENOG4105CBX hi0933 family F0H33_08155 ENOG4108VWS Yaeq family F0H33_08165 ENOG4105VEQ Cold shock protein F0H33_08170 ENOG4108K3A Glutathione S-transferase F0H33_08180 ENOG4105CNG UPF0061 protein F0H33_08190 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0H33_08200 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) F0H33_08205 ENOG4105C1J atp-dependent rna helicase F0H33_08210 ENOG4105C5H ABC transporter F0H33_08225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0H33_08235 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F0H33_08245 ENOG4105DUX Transporter F0H33_08275 ENOG41090MY MarR family Transcriptional regulator F0H33_08290 ENOG4105DP0 ferredoxin-NADP reductase F0H33_08310 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F0H33_08320 ENOG4107GFK fumarate F0H33_08335 ENOG4105HDD phospholipase F0H33_08345 ENOG4105VEQ Cold shock protein F0H33_08360 ENOG4105CUZ uba thif-type nad fad binding protein F0H33_08365 ENOG4105F8V Hydrolase, tatD family F0H33_08380 ENOG4105C1G acyl-Coa dehydrogenase F0H33_08390 ENOG4105CDU Replicative dna helicase F0H33_08395 ENOG4105CVP deoxyribo-dipyrimidine photolyase F0H33_08405 ENOG4105CDV Ompa motb domain protein F0H33_08410 ENOG4105EJC lysr family transcriptional regulator F0H33_08425 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0H33_08470 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) F0H33_08475 ENOG4108Z1B Cyclase dehydrase F0H33_08485 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F0H33_08490 ENOG41090R7 Ferric uptake F0H33_08495 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F0H33_08500 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) F0H33_08505 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ F0H33_08510 ENOG4105CFG Acts as a chaperone (By similarity) F0H33_08515 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F0H33_08530 ENOG4105EHE chorismate mutase- prephenate dehydrogenase F0H33_08540 ENOG4105BZ1 (ABC) transporter F0H33_08560 ENOG4105BZU Histidine kinase F0H33_08575 ENOG4105C7S Dehydrogenase F0H33_08580 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F0H33_08590 ENOG4105EZE Cupin 4 family protein F0H33_08595 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 F0H33_08605 ENOG4107QTF adenylosuccinate lyase F0H33_08645 ENOG4105CZV ABC transporter F0H33_08650 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F0H33_08660 ENOG4108V06 Glutathione peroxidase F0H33_08665 ENOG4108V1T peptidylprolyl cis-trans isomerase F0H33_08670 ENOG4105C6Y Udp-glucose 6-dehydrogenase F0H33_08675 ENOG41069P5 Protein slyX homolog F0H33_08685 ENOG4105EXC Acyl-transferase F0H33_08695 ENOG4105C3R Methionine synthase F0H33_08700 ENOG4105C3R Methionine synthase F0H33_08710 ENOG4105C1G acyl-Coa dehydrogenase F0H33_08715 ENOG4105F2I Transposase F0H33_08770 ENOG4108781 Fimbrial protein F0H33_08775 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F0H33_08790 ENOG4105BZS acriflavin resistance protein F0H33_08795 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0H33_08805 ENOG4105C7I Dehydrogenase F0H33_08835 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F0H33_08840 ENOG4105C4M (Ubiquinol oxidase) subunit I F0H33_08845 ENOG4108JJ9 ABC, transporter F0H33_08850 ENOG4108JJ8 (ABC) transporter F0H33_08855 ENOG4105DWV Homoserine O-trans-acetylase F0H33_08865 ENOG4105KWW Biogenesis protein F0H33_08875 ENOG4105DA4 cytochrome c-type biogenesis protein F0H33_08880 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) F0H33_08890 ENOG41060IM Heme exporter protein F0H33_08895 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) F0H33_08900 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) F0H33_08905 ENOG4105CHM Aminotransferase F0H33_08930 ENOG4105FE9 pseudouridine synthase F0H33_08935 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) F0H33_08940 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) F0H33_08945 ENOG4105K9H YciI-like protein F0H33_08980 ENOG4105DRS transport system, permease F0H33_08990 ENOG4108UHU Aldolase F0H33_08995 ENOG4105C01 Dihydroxy-acid dehydratase F0H33_09020 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) F0H33_09030 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) F0H33_09045 ENOG4105E33 succinate dehydrogenase F0H33_09050 ENOG410681N tpr repeat protein F0H33_09060 ENOG4105D60 lipoprotein releasing system transmembrane protein F0H33_09080 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 F0H33_09095 ENOG4105BZ1 (ABC) transporter F0H33_09120 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) F0H33_09125 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase F0H33_09160 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) F0H33_09165 ENOG4108JPW Aminotransferase F0H33_09175 ENOG4105J3Q acyl carrier protein F0H33_09215 ENOG4105BZ1 (ABC) transporter F0H33_09235 ENOG4105WH1 Two component transcriptional regulator luxr family F0H33_09245 ENOG4105C03 ribonuclease F0H33_09250 ENOG4105EI2 Pseudouridine synthase F0H33_09260 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) F0H33_09275 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) F0H33_09290 ENOG4106RE7 Cytochrome F0H33_09295 ENOG4105C1P efflux transporter, rnd family, mfp subunit F0H33_09320 ENOG4105DWY Agmatine deiminase F0H33_09330 ENOG4105YK5 50S ribosomal protein L36 F0H33_09335 ENOG4105CAT Cytidine monophosphate kinase F0H33_09340 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) F0H33_09345 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) F0H33_09355 ENOG4105CFV Tetratricopeptide repeat protein F0H33_09360 ENOG4105ESV Glycosyl transferase, family 4 F0H33_09370 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F0H33_09375 ENOG4105CHU acetyl-coa acetyltransferase F0H33_09390 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F0H33_09405 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) F0H33_09415 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) F0H33_09420 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) F0H33_09425 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) F0H33_09430 ENOG4105CVM Molybdenum cofactor synthesis domain protein F0H33_09435 ENOG4105D06 uba thif-type nad fad binding protein F0H33_09440 ENOG4105CKD glutathione-regulated potassium-efflux system protein F0H33_09460 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F0H33_09465 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F0H33_09470 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F0H33_09490 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F0H33_09495 ENOG4105KST dependent repressor F0H33_09500 ENOG4108Z6B deaminase F0H33_09520 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) F0H33_09540 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F0H33_09550 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class F0H33_09570 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) F0H33_09580 ENOG4105CQZ Histidine kinase F0H33_09585 ENOG4105BZM domain protein F0H33_09590 ENOG4105BZU Histidine kinase F0H33_09745 ENOG4105CDU Replicative dna helicase F0H33_09760 ENOG4105NI8 Cytosine-specific methyltransferase F0H33_09825 ENOG4108TFU terminase (Small subunit) F0H33_10035 ENOG4105F32 YngK protein F0H33_10045 ENOG4105DMF Dehydrogenase F0H33_10125 ENOG4105IBP Cyclic peptide transporter F0H33_10190 ENOG4107QKA exodeoxyribonuclease V beta F0H33_10275 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F0H33_10285 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F0H33_10290 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F0H33_10300 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain F0H33_10305 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) F0H33_10310 ENOG4108RPX mosc domain containing protein F0H33_10315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0H33_10330 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F0H33_10335 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F0H33_10355 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) F0H33_10375 ENOG4105EGZ biosynthesis protein F0H33_10405 ENOG4108VKM cytochrome b561 F0H33_10425 ENOG4105EMN RNA polymerase sigma factor F0H33_10440 ENOG41060IM Heme exporter protein F0H33_10455 ENOG4105DA4 cytochrome c-type biogenesis protein F0H33_10460 ENOG4107QX9 Thiol disulfide interChange protein F0H33_10465 ENOG4105KWW Biogenesis protein F0H33_10480 ENOG4107R4J Chloride channel F0H33_10485 ENOG4105D1H recombination factor protein RarA F0H33_10495 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) F0H33_10505 ENOG4105CNU cell division protein FtsK F0H33_10510 ENOG4105C3M thioredoxin reductase F0H33_10520 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) F0H33_10525 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) F0H33_10530 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0H33_10535 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) F0H33_10550 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F0H33_10580 ENOG4105BZU Histidine kinase F0H33_10590 ENOG4105BZU Histidine kinase F0H33_10615 ENOG4107R88 Chemotaxis protein (CheV) F0H33_10625 ENOG4108ZC9 flagellar basal-body rod protein flgc F0H33_10630 ENOG4105W00 Flagellar hook capping protein F0H33_10635 ENOG4105BZE flagellar hook protein, FlgE F0H33_10640 ENOG4108KPB Flagellar basal-body rod protein FlgF F0H33_10645 ENOG4105CGA flagellar basal-body rod protein FlgG F0H33_10650 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) F0H33_10660 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj F0H33_10665 ENOG4105E1Q flagellar hook-associated protein F0H33_10665 ENOG4105E1Q flagellar hook-associated protein F0H33_10670 ENOG4105DTJ flagellar hook-associated protein F0H33_10680 ENOG4107W9T flagellar hook-associated F0H33_10685 ENOG4105MQ3 flagellar protein FliS F0H33_10700 ENOG4105WH1 Two component transcriptional regulator luxr family F0H33_10705 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0H33_10710 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) F0H33_10715 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0H33_10730 ENOG4108P1X synthase F0H33_10740 ENOG4105CHR reductase F0H33_10770 ENOG4107RGC Glycosyl transferase, family 2 F0H33_10775 ENOG4105VQ0 flagellar hook-basal body complex protein fliE F0H33_10780 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) F0H33_10785 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F0H33_10795 ENOG4108JIR Flagellum-specific ATP synthase F0H33_10815 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F0H33_10820 ENOG4105DD5 Flagellar motor switch protein F0H33_10825 ENOG4105K0P flagellar biosynthesis protein F0H33_10830 ENOG4105CN7 Flagellar biosynthetic protein FliP F0H33_10835 ENOG4105VS8 Flagellar biosynthetic protein fliq F0H33_10840 ENOG4105D19 Role in flagellar biosynthesis (By similarity) F0H33_10845 ENOG4105BZU Histidine kinase F0H33_10850 ENOG4105BZU Histidine kinase F0H33_10855 ENOG4105D00 flagellar biosynthetic protein flhB F0H33_10860 ENOG4105D7B Flagellar biosynthesis protein flha F0H33_10865 ENOG4105FZW flagellar biosynthesis regulator FlhF F0H33_10870 ENOG4107R21 site-determining protein F0H33_10875 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0H33_10880 ENOG4108VYJ response regulator receiver protein F0H33_10885 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) F0H33_10890 ENOG4105CBS Chea signal transduction histidine kinase F0H33_10895 ENOG4105E14 MotA TolQ exbB proton channel F0H33_10900 ENOG4106VK6 Flagellar motor protein F0H33_10905 ENOG4107QJE Chromosome Partitioning Protein F0H33_10910 ENOG4108V3W Chemotaxis protein, CheW F0H33_10920 ENOG4108VYJ response regulator receiver protein F0H33_10925 ENOG4105CBS Chea signal transduction histidine kinase F0H33_10930 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10935 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10940 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10945 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10955 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10960 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10965 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10970 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10980 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_10990 ENOG4108V3W Chemotaxis protein, CheW F0H33_11000 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_11010 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_11015 ENOG4105BZU Histidine kinase F0H33_11020 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) F0H33_11025 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) F0H33_11030 ENOG4105BZU Histidine kinase F0H33_11040 ENOG4107QIJ Aconitate hydratase 2 F0H33_11055 ENOG4107QM5 aconitate hydratase F0H33_11065 ENOG4105CEY Amp-dependent synthetase and ligase F0H33_11070 ENOG41060WC Enoyl-CoA hydratase F0H33_11075 ENOG4105BZU Histidine kinase F0H33_11080 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase F0H33_11110 ENOG4108RTU Aldolase F0H33_11115 ENOG4105CXK mandelate racemase muconate lactonizing F0H33_11125 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 F0H33_11130 ENOG4108Z4U Ferredoxin F0H33_11140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F0H33_11150 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F0H33_11155 ENOG4108IAB Phoh family F0H33_11190 ENOG4105DWF phosphomethylpyrimidine kinase F0H33_11210 ENOG4105F52 Transcriptional regulator F0H33_11240 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) F0H33_11255 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) F0H33_11260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) F0H33_11265 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F0H33_11270 ENOG4107TH8 cina domain protein F0H33_11275 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F0H33_11280 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F0H33_11285 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) F0H33_11290 ENOG4105EEI dihydropteroate synthase F0H33_11295 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F0H33_11300 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) F0H33_11305 ENOG4105HBR Rna-binding protein F0H33_11315 ENOG4108K5P (LipO)protein F0H33_11320 ENOG4108UM1 dedA family F0H33_11325 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) F0H33_11330 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) F0H33_11340 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) F0H33_11345 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) F0H33_11350 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) F0H33_11355 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F0H33_11360 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) F0H33_11365 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F0H33_11370 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F0H33_11380 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0H33_11390 ENOG4105CJ3 phosphate transporter F0H33_11410 ENOG4105DEN Luciferase family F0H33_11415 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F0H33_11420 ENOG4105C72 UPF0176 protein F0H33_11440 ENOG4105BZU Histidine kinase F0H33_11445 ENOG4105CBC glutamate synthase F0H33_11450 ENOG4107QQG Dehydrogenase F0H33_11460 ENOG4105ETE Transcriptional regulator (LacI family F0H33_11465 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F0H33_11470 ENOG4105DE4 1-phosphofructokinase F0H33_11475 ENOG4105DM4 PTS System F0H33_11485 ENOG4105XJC Two component transcriptional regulator (Winged helix family F0H33_11510 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F0H33_11595 ENOG4105CC0 LysR family Transcriptional regulator F0H33_11600 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) F0H33_11625 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) F0H33_11630 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) F0H33_11635 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) F0H33_11670 ENOG4105PDP Short chain dehydrogenase F0H33_11685 ENOG4105CI2 imidazolone-5-propionate hydrolase F0H33_11690 ENOG4105C84 Histidine ammonia-lyase F0H33_11700 ENOG4105CGP Urocanate hydratase F0H33_11715 ENOG41062JF Transcriptional regulator F0H33_11730 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0H33_11735 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) F0H33_11745 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) F0H33_11750 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F0H33_11755 ENOG4105CIH Imidazole acetol-phosphate transaminase F0H33_11760 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) F0H33_11770 ENOG4105K9Q Binds to the 23S rRNA (By similarity) F0H33_11775 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) F0H33_11780 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) F0H33_11790 ENOG4108Z4V iron-sulfur cluster assembly F0H33_11815 ENOG4105WH1 Two component transcriptional regulator luxr family F0H33_11860 ENOG41077A9 carbonic anhydrase F0H33_11865 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) F0H33_11875 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) F0H33_11880 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) F0H33_11885 ENOG4105CJB Exodeoxyribonuclease I F0H33_11910 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F0H33_11985 ENOG4108HRK Histidine kinase F0H33_11990 ENOG4105EWT decarboxylase family F0H33_11995 ENOG4108KPZ tonB-dependent Receptor F0H33_12000 ENOG41076UM multiple antibiotic resistance (MarC)-related protein F0H33_12005 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase F0H33_12010 ENOG4105M2J Glutaredoxin F0H33_12015 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0H33_12020 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F0H33_12025 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F0H33_12035 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F0H33_12050 ENOG4105KB2 stringent starvation protein b F0H33_12055 ENOG4107MKT Stringent starvation protein a F0H33_12060 ENOG4105EIX cytochrome c1 F0H33_12065 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F0H33_12070 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F0H33_12075 ENOG4105E4C Lytic transglycosylase catalytic F0H33_12080 ENOG4108K3A Glutathione S-transferase F0H33_12085 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F0H33_12090 ENOG4105C9A Phoh family F0H33_12105 ENOG4108JU5 Magnesium and cobalt efflux protein F0H33_12120 ENOG4105C26 Dehydrogenase F0H33_12125 ENOG4105D38 putrescine abc transporter F0H33_12130 ENOG4105F38 ABC transporter, permease F0H33_12135 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0H33_12165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0H33_12175 ENOG4105CFQ glutamine synthetase F0H33_12180 ENOG4108Z86 Glutamine amidotransferase F0H33_12185 ENOG4105CFQ glutamine synthetase F0H33_12190 ENOG4105CJP fad dependent oxidoreductase F0H33_12195 ENOG4105BZU Histidine kinase F0H33_12200 ENOG4105CSH Transporter F0H33_12215 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit F0H33_12220 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F0H33_12230 ENOG4105F4R Transcriptional regulator mode F0H33_12245 ENOG4105C26 Dehydrogenase F0H33_12250 ENOG4107VRI Transcriptional regulator F0H33_12255 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0H33_12260 ENOG4105DCF alanine dehydrogenase F0H33_12265 ENOG4105C26 Dehydrogenase F0H33_12280 ENOG4106BRA Membrane F0H33_12285 ENOG4105BZU Histidine kinase F0H33_12290 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase F0H33_12295 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) F0H33_12330 ENOG4105KHC sulfurtransferase F0H33_12340 ENOG4108V1T peptidylprolyl cis-trans isomerase F0H33_12345 ENOG4105E39 Enoyl-CoA hydratase F0H33_12355 ENOG4105CSM endonuclease III F0H33_12360 ENOG4105CHH sulfate transporter F0H33_12365 ENOG4107B2H carbonic anhydrase F0H33_12380 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) F0H33_12385 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) F0H33_12390 ENOG4105C8U phosphate abc transporter F0H33_12395 ENOG4105E2Z phosphate ABC transporter (Permease F0H33_12400 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F0H33_12405 ENOG4108UTW Plays a role in the regulation of phosphate uptake F0H33_12415 ENOG4105E18 UPF0276 protein F0H33_12425 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) F0H33_12445 ENOG4105C2N RNA methyltransferase TrmH family group 3 F0H33_12455 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F0H33_12490 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0H33_12495 ENOG4105CW7 secretion protein, HlyD family F0H33_12515 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0H33_12520 ENOG4108UWD Iron-storage protein F0H33_12535 ENOG4105CAQ asparagine synthetase F0H33_12545 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) F0H33_12550 ENOG4105KUZ arsenate reductase F0H33_12560 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) F0H33_12565 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F0H33_12605 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) F0H33_12610 ENOG4105BZU Histidine kinase F0H33_12615 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F0H33_12620 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) F0H33_12625 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F0H33_12630 ENOG4105KNE Phosphatidate cytidylyltransferase F0H33_12640 ENOG4105DZP Membrane-associated zinc metalloprotease F0H33_12650 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0H33_12655 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) F0H33_12660 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0H33_12665 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0H33_12670 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F0H33_12680 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) F0H33_12695 ENOG4108YXA Membrane F0H33_12795 ENOG4105BZ1 (ABC) transporter F0H33_12815 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) F0H33_12825 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) F0H33_12835 ENOG4105BZU Histidine kinase F0H33_12840 ENOG4105FE9 pseudouridine synthase F0H33_12935 ENOG4105UGU tonB-dependent Receptor F0H33_12950 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit F0H33_12955 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding F0H33_12960 ENOG4105C7W Xanthine dehydrogenase F0H33_12985 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin F0H33_13000 ENOG4105MYN Zinc uptake regulation protein F0H33_13035 ENOG4105EB3 Histidine kinase F0H33_13045 ENOG4105D6S protein involved in catabolism of external DNA F0H33_13065 ENOG4108JA2 transcriptioN-repair coupling factor F0H33_13075 ENOG4105CBS Chea signal transduction histidine kinase F0H33_13080 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_13085 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_13090 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_13095 ENOG4108V3W Chemotaxis protein, CheW F0H33_13100 ENOG4105BZU Histidine kinase F0H33_13105 ENOG4105BZU Histidine kinase F0H33_13110 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) F0H33_13120 ENOG4105DQ6 Transposase F0H33_13130 ENOG4105CT4 transporter F0H33_13175 ENOG4105D22 carbon starvation protein F0H33_13180 ENOG4105VCD cytoplasmic protein F0H33_13185 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 F0H33_13205 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein F0H33_13210 ENOG4105EPD Oligopeptide transporter, Opt family F0H33_13215 ENOG4105DUX Transporter F0H33_13235 ENOG4108UUM single-stranded DNA-binding protein F0H33_13240 ENOG4105EAH synthase F0H33_13255 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) F0H33_13270 ENOG4105CFH Aspartokinase F0H33_13275 ENOG4105JAB phenazine biosynthesis protein, phzf family F0H33_13285 ENOG4108Z9K Osmotically inducible protein F0H33_13300 ENOG4105DR5 peptidase F0H33_13315 ENOG4107R7Y intracellular protease Pfpi family F0H33_13335 ENOG4105C3K feS assembly ATPase SufC F0H33_13340 ENOG4105JRK feS assembly protein SufD F0H33_13345 ENOG4105C9B Cysteine desulfurase F0H33_13355 ENOG4105VQD rieske 2fe-2S domain-containing protein F0H33_13360 ENOG4108ESX Receptor F0H33_13385 ENOG4105CJ2 (LipO)protein F0H33_13390 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F0H33_13400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0H33_13410 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein F0H33_13425 ENOG4105EHM Aminoglycoside phosphotransferase F0H33_13430 ENOG4108S0S Nucleotidyl transferase F0H33_13440 ENOG4105C02 permease F0H33_13450 ENOG4105CXB phosphoribosylaminoimidazole synthetase F0H33_13465 ENOG4108V3E phosphoribosylglycinamide formyltransferase F0H33_13490 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F0H33_13500 ENOG4105C2X Arabinose 5-phosphate isomerase F0H33_13505 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase F0H33_13520 ENOG4108IUZ ABC transporter F0H33_13525 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0H33_13530 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA F0H33_13535 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN F0H33_13540 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) F0H33_13545 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) F0H33_13560 ENOG41080Z8 PHOSPHOCARRIER protein F0H33_13565 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F0H33_13570 ENOG4105CJW magnesium transporter F0H33_13590 ENOG4105C85 amino acid F0H33_13600 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_13620 ENOG4105CXT aspartate transcarbamylase F0H33_13625 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) F0H33_13630 ENOG4108UJU UPF0301 protein F0H33_13640 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F0H33_13645 ENOG4105CZX twitching motility protein F0H33_13650 ENOG4105CZX twitching motility protein F0H33_13655 ENOG4105DFA alanine racemase domain protein F0H33_13665 ENOG4105II7 pyrroline-5-carboxylate reductase F0H33_13675 ENOG4108Z4X TRANSCRIPTIONal F0H33_13690 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) F0H33_13695 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) F0H33_13700 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F0H33_13705 ENOG4105D49 3-dehydroquinate synthase F0H33_13715 ENOG4105BZS acriflavin resistance protein F0H33_13730 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) F0H33_13735 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0H33_13740 ENOG4105BZU Histidine kinase F0H33_13745 ENOG4105BZU Histidine kinase F0H33_13755 ENOG4105DS1 cytochrome b561 F0H33_13770 ENOG4105EJQ L-serine dehydratase F0H33_13775 ENOG4105BZU Histidine kinase F0H33_13780 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F0H33_13785 ENOG4105CFH Aspartokinase F0H33_13790 ENOG4105C28 cystathionine F0H33_13795 ENOG4106TYC homoserine o-acetyltransferase (EC 2.3.1.31) F0H33_13805 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) F0H33_13810 ENOG4108UT2 hemolysin iii F0H33_13815 ENOG41066T0 asmA family F0H33_13820 ENOG41080XP Cbs domain F0H33_13830 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase F0H33_13835 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) F0H33_13885 ENOG4107QPN acyl-Coa dehydrogenase F0H33_13890 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) F0H33_13980 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) F0H33_13985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) F0H33_14000 ENOG4107QX8 SPFH domain, Band 7 family protein F0H33_14010 ENOG4105KK4 UPF0060 membrane protein F0H33_14015 ENOG4105DXN mazG family F0H33_14020 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase F0H33_14025 ENOG4107RK2 ADP-ribose diphosphatase NudE F0H33_14035 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F0H33_14045 ENOG4105CHC glucokinase (EC 2.7.1.2) F0H33_14060 ENOG4105VRS hydrolase family 18 F0H33_14065 ENOG4105E2D ec 3.2.1.52 F0H33_14095 ENOG4105CWX Alpha-1,2-mannosidase F0H33_14205 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0H33_14360 ENOG4108Z12 YiaAB two helix domain-containing protein F0H33_14425 ENOG4105CS6 Rhs element vgr protein F0H33_14510 ENOG4108RIR Molybdenum cofactor biosynthesis protein F0H33_14520 ENOG4105CSR polyphosphate kinase 2 F0H33_14530 ENOG4107QX9 Thiol disulfide interChange protein F0H33_14535 ENOG4107S2Z UPF0761 membrane protein F0H33_14540 ENOG4105CS1 NAD(P)H quinone oxidoreductase F0H33_14555 ENOG4108Z66 YbaK ebsC protein F0H33_14565 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F0H33_14570 ENOG4105CM2 brancheD-chain amino acid aminotransferase F0H33_14585 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F0H33_14590 ENOG4105W8H transhydrogenase (subunit alpha F0H33_14610 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) F0H33_14630 ENOG4105C2M dna polymerase I F0H33_14675 ENOG4107RNH Outer membrane receptor FepA F0H33_14690 ENOG4105CKD glutathione-regulated potassium-efflux system protein F0H33_14700 ENOG4105GAV receptor F0H33_14710 ENOG4105DJU Siderophore biosynthesis protein F0H33_14720 ENOG4105DBM Siderophore biosynthesis protein F0H33_14725 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) F0H33_14735 ENOG4105VIF phosphate starvation-inducible protein F0H33_14755 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0H33_14785 ENOG4108HF7 Gcn5-related n-acetyltransferase F0H33_14795 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0H33_14805 ENOG4108K4C ec 3.1.3.12 F0H33_14810 ENOG4105BZP glycoside hydrolase 15-related F0H33_14815 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase F0H33_14820 ENOG4105DZG Dehydrogenase F0H33_14835 ENOG4105C34 Pseudouridine synthase F0H33_14840 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane F0H33_14850 ENOG4108IJ8 ABC transporter F0H33_14855 ENOG4105E90 ABC transporter F0H33_14880 ENOG4105C4K Nad synthetase F0H33_14905 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F0H33_14915 ENOG4107TUY Histidine kinase F0H33_14920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0H33_14935 ENOG4107QHF type ii secretion system protein e F0H33_14955 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) F0H33_14965 ENOG4105BZU Histidine kinase F0H33_14970 ENOG4105ETX regulatoR F0H33_14980 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) F0H33_15015 ENOG4107STF Involved in phosphonate degradation (By similarity) F0H33_15030 ENOG4108Z86 Glutamine amidotransferase F0H33_15035 ENOG4108NIW Leucine export protein LeuE F0H33_15040 ENOG4105CVG Homoserine O-transsuccinylase F0H33_15045 ENOG4105CFQ glutamine synthetase F0H33_15070 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) F0H33_15075 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) F0H33_15080 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) F0H33_15100 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase F0H33_15115 ENOG4105ETE Transcriptional regulator (LacI family F0H33_15130 ENOG4105C2N RNA methyltransferase TrmH family group 3 F0H33_15155 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_15160 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) F0H33_15165 ENOG4105C11 sulfate adenylyltransferase), subunit 2 F0H33_15170 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F0H33_15175 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) F0H33_15180 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) F0H33_15210 ENOG4105K89 arsenate reductase F0H33_15215 ENOG4105BZU Histidine kinase F0H33_15225 ENOG4107R11 Transcriptional regulator F0H33_15230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0H33_15245 ENOG4105C5R Aminotransferase F0H33_15270 ENOG4105DU0 nucleoside hydrolase F0H33_15285 ENOG4108UVJ appr-1-p processing domain protein F0H33_15290 ENOG4107R1Y fructose-bisphosphate aldolase F0H33_15295 ENOG4105CA9 Pyruvate kinase F0H33_15305 ENOG4105BZA Phosphoglycerate kinase F0H33_15320 ENOG4108NVR Methyl-accepting chemotaxis F0H33_15340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F0H33_15345 ENOG4105EIF outer membrane protein W F0H33_15350 ENOG4105EIF outer membrane protein W F0H33_15365 ENOG41080HT Transcriptional regulator, arsr family F0H33_15375 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F0H33_15380 ENOG4105E0C molybdate abc transporter F0H33_15385 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) F0H33_15410 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein F0H33_15415 ENOG4105DR5 peptidase F0H33_15440 ENOG4105CV1 Transketolase (EC 2.2.1.1) F0H33_15445 ENOG4105CK2 sodium dicarboxylate symporter F0H33_15475 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0H33_15480 ENOG4105E4G Type IV pilus F0H33_15505 ENOG4108JQC penicillin-binding protein 1A F0H33_15520 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) F0H33_15525 ENOG4107RAQ aminopeptidase F0H33_15535 ENOG4105BZU Histidine kinase F0H33_15545 ENOG4105W8B Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) F0H33_15555 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F0H33_15565 ENOG4105E66 phosphoriboisomerase A F0H33_15585 ENOG4105VCQ rubredoxin F0H33_15590 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) F0H33_15600 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase F0H33_15615 ENOG41090JD Blue (Type 1) copper domain protein F0H33_15625 ENOG4107TJ9 Cytochrome F0H33_15635 ENOG4105C8Y Acetylornithine aminotransferase F0H33_15645 ENOG4105DKQ ROK family F0H33_15660 ENOG410841Q phosphoesterase PA-phosphatase related protein F0H33_15670 ENOG4105DFU Cell wall formation (By similarity) F0H33_15675 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) F0H33_15695 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for F0H33_15705 ENOG4105F0N pyrophosphate phospho-hydrolase F0H33_15720 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) F0H33_15730 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F0H33_15745 ENOG4105C7B Threonine dehydratase F0H33_15750 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) F0H33_15760 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F0H33_15765 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F0H33_15770 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) F0H33_15775 ENOG4105BZU Histidine kinase F0H33_15785 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) F0H33_15790 ENOG4105DFG type I secretion outer membrane protein F0H33_15795 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase F0H33_15800 ENOG4105D1S lipid A biosynthesis F0H33_15825 ENOG4108JJA ABC, transporter F0H33_15865 ENOG4105C6K Malic enzyme F0H33_15870 ENOG4105CK2 sodium dicarboxylate symporter F0H33_15895 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC F0H33_15900 ENOG4105DHQ Histidine kinase F0H33_15915 ENOG4105D4T Citrate transporter F0H33_15920 ENOG4105CHR reductase F0H33_15925 ENOG4105ETE Transcriptional regulator (LacI family F0H33_15940 ENOG4107QW3 Sucrose phosphorylase F0H33_15955 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F0H33_15960 ENOG4105CHM Aminotransferase F0H33_16005 ENOG4105CD3 dihydroorotase F0H33_16035 ENOG4105JAB phenazine biosynthesis protein, phzf family F0H33_16040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0H33_16050 ENOG4108QBQ Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity) F0H33_16065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0H33_16070 ENOG4105E0F Histidine kinase F0H33_16105 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) F0H33_16110 ENOG4106RE7 Cytochrome F0H33_16145 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate F0H33_16155 ENOG4105CE4 GlcNAc 6-P deacetylase F0H33_16160 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F0H33_16165 ENOG4107KJX Transcriptional regulator F0H33_16170 ENOG4105EDR glucose galactose transporter F0H33_16175 ENOG4105FDP GntR family transcriptional regulator F0H33_16190 ENOG4105CNT hydrolase family 2 F0H33_16230 ENOG4105BZU Histidine kinase F0H33_16240 ENOG4105BZU Histidine kinase F0H33_16250 ENOG4105W4M Transport-associated protein F0H33_16255 ENOG4105D9R oxidoreductase F0H33_16260 ENOG4108J5G 6-phosphogluconate dehydrogenase F0H33_16270 ENOG4105ECP epimerase F0H33_16285 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP F0H33_16290 ENOG4105D6F Phosphatase F0H33_16315 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) F0H33_16325 ENOG4105DXX methyltransferase F0H33_16350 ENOG4105SYT Methylenetetrahydrofolate reductase F0H33_16360 ENOG4105M6F mutator MutT protein F0H33_16375 ENOG4105DR5 peptidase F0H33_16385 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) F0H33_16390 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F0H33_16395 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F0H33_16400 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) F0H33_16405 ENOG4105CPF Cell wall formation (By similarity) F0H33_16410 ENOG4105DFU Cell wall formation (By similarity) F0H33_16415 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F0H33_16425 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) F0H33_16430 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) F0H33_16435 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F0H33_16440 ENOG4105CJN penicillin-binding protein F0H33_16445 ENOG4106932 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) F0H33_16450 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) F0H33_16455 ENOG4108V6E Cell division protein mraZ F0H33_16495 ENOG4105S2T inner membrane protein YbcI F0H33_16500 ENOG4105CQB FAD linked oxidase domain protein F0H33_16505 ENOG4105EEX Two component transcriptional regulator (Winged helix family F0H33_16510 ENOG4105C08 Histidine kinase F0H33_16515 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F0H33_16520 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F0H33_16525 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F0H33_16550 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) F0H33_16555 ENOG4107YIM Involved in the transcription termination process (By similarity) F0H33_16560 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) F0H33_16565 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F0H33_16575 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F0H33_16585 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) F0H33_16590 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) F0H33_16620 ENOG4105C5H ABC transporter F0H33_16625 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F0H33_16650 ENOG410802X bacteriophage n4 adsorption protein b F0H33_16660 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F0H33_16665 ENOG4105EJG cellulose synthase F0H33_16715 ENOG4108K85 Transcriptional regulator F0H33_16730 ENOG4105GVR general secretion pathway protein D F0H33_16740 ENOG410678M general secretion pathway protein M F0H33_16745 ENOG41090VX general secretion pathway protein L F0H33_16750 ENOG4105UV2 general secretion pathway protein K F0H33_16755 ENOG41069G9 General secretion pathway protein J F0H33_16765 ENOG4105WMT general secretion pathway protein h F0H33_16775 ENOG4105D7Q type ii secretion system F0H33_16780 ENOG4107QHF type ii secretion system protein e F0H33_16785 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F0H33_16800 ENOG4105C8Q Methyl-accepting chemotaxis F0H33_16805 ENOG4107QIK phosphoribosylformylglycinamidine synthase F0H33_16810 ENOG4105T95 Thiol disulfide interChange protein F0H33_16815 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F0H33_16840 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F0H33_16845 ENOG4105MYG DNA polymerase iii, chi subunit F0H33_16860 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F0H33_16880 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F0H33_16895 ENOG4108YX2 DNA-binding protein F0H33_16910 ENOG4105DHJ ABC, transporter F0H33_16915 ENOG4108SNX Mammalian cell entry related domain protein F0H33_16930 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase F0H33_16945 ENOG4107QP7 CoA-transferase subunit A F0H33_16950 ENOG4107QKV phosphomannomutase F0H33_16955 ENOG4105CJT Mannose-1-phosphate guanylyltransferase F0H33_16960 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase F0H33_16965 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase F0H33_16980 ENOG4105BZJ Electron transfer flavoprotein F0H33_16985 ENOG4105C10 Electron transfer flavoprotein F0H33_17000 ENOG4105IQ5 FAD linked oxidase domain protein F0H33_17005 ENOG4108RG3 short-chain dehydrogenase reductase F0H33_17030 ENOG4105BZ8 glutamate synthase F0H33_17080 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F0H33_17085 ENOG4105EY8 ABC transporter F0H33_17095 ENOG4105C28 cystathionine F0H33_17120 ENOG4105CZX twitching motility protein F0H33_17125 ENOG4108RXX maleylacetoacetate isomerase F0H33_17140 ENOG4105C1J atp-dependent rna helicase F0H33_17145 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F0H33_17170 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) F0H33_17175 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F0H33_17180 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F0H33_17185 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) F0H33_17200 ENOG4105DGW oligopeptidase A F0H33_17215 ENOG4105C59 p-type ATPase F0H33_17230 ENOG4105E3B Multicopper oxidase F0H33_17245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F0H33_17255 ENOG4105C19 ABC transporter F0H33_17265 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F0H33_17270 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F0H33_17275 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) F0H33_17285 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0H33_17290 ENOG4105BZU Histidine kinase F0H33_17300 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) F0H33_17315 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) F0H33_17320 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) F0H33_17325 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) F0H33_17330 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) F0H33_17335 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F0H33_17340 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F0H33_17345 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) F0H33_17350 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) F0H33_17365 ENOG4107QN2 dihydrolipoyl dehydrogenase F0H33_17370 ENOG4107QSN dihydrolipoamide acetyltransferase F0H33_17400 ENOG4105D01 (LipO)protein F0H33_17405 ENOG4108UMI ABC transporter, permease F0H33_17410 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F0H33_17415 ENOG4108EHX EamA-like transporter family F0H33_17420 ENOG4108VPT UPF0234 protein F0H33_17430 ENOG4105I08 Pseudouridine synthase F0H33_17435 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) F0H33_17455 ENOG4105BZU Histidine kinase F0H33_17475 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F0H33_17480 ENOG4105MWK D-amino acid dehydrogenase, small subunit F0H33_17485 ENOG4105EW9 transcriptional regulator AsnC family F0H33_17505 ENOG4107RD7 Flagellar Motor Protein, MotA F0H33_17510 ENOG4105ER2 Ompa motb domain protein F0H33_17555 ENOG4105E3A (ABC) transporter F0H33_17560 ENOG4105DA5 (ABC) transporter F0H33_17565 ENOG4105EEQ Na H antiporter F0H33_17580 ENOG4108UN4 phage SPO1 DNA polymerase-related protein F0H33_17595 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F0H33_17620 ENOG4108FN7 Aldo keto reductase F0H33_17630 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F0H33_17635 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F0H33_17655 ENOG4105BZU Histidine kinase F0H33_17705 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) F0H33_17715 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F0H33_17725 ENOG4105E0K tonB-dependent siderophore receptor F0H33_17735 ENOG4108VAC response regulator F0H33_17740 ENOG4108HRK Histidine kinase F0H33_17765 ENOG4107QTZ amino acid F0H33_17780 ENOG4106R7G Glycoside hydrolase family 5 F0H33_17795 ENOG4105E4C Lytic transglycosylase catalytic F0H33_17820 ENOG4105CF7 AraC family transcriptional regulator F0H33_17830 ENOG4107QUT magnesium and cobalt transport protein CorA F0H33_17840 ENOG4105DFI Membrane F0H33_17860 ENOG4107QS8 (LipO)protein F0H33_17870 ENOG4108MYR Secreted protein F0H33_17990 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) F0H33_17995 ENOG41069D7 Methyl-accepting chemotaxis F0H33_18010 ENOG4108YYC ycei family F0H33_18040 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase F0H33_18050 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) F0H33_18065 ENOG41082IR Excinuclease ABC C subunit domain protein F0H33_18070 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) F0H33_18075 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) F0H33_18080 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) F0H33_18090 ENOG4105VF7 tolerance protein F0H33_18095 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) F0H33_18100 ENOG4107USA Thioredoxin F0H33_18110 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) F0H33_18115 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein F0H33_18120 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F0H33_18135 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) F0H33_18155 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) F0H33_18165 ENOG4108HPI phosphatidate Cytidylyltransferase F0H33_18185 ENOG4105E8V Alpha Beta Hydrolase Fold protein F0H33_18190 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase F0H33_18195 ENOG4105DC1 bifunctional purine biosynthesis protein purh F0H33_18200 ENOG4105C12 Phosphoribosylglycinamide synthetase F0H33_18205 ENOG4105EM2 membrane F0H33_18210 ENOG4105EQ0 Major Facilitator superfamily F0H33_18250 ENOG4105E09 nadh pyrophosphatase F0H33_18255 ENOG4108YX9 iron--sulfur cluster insertion protein erpA F0H33_18280 ENOG4105BZU Histidine kinase F0H33_18285 ENOG4108UQY Iron-storage protein F0H33_18290 ENOG4105W53 bacterioferritin-associated ferredoxin F0H33_18295 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F0H33_18310 ENOG4108UJD 30S ribosomal protein S9 F0H33_18315 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) F0H33_18320 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) F0H33_18335 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F0H33_18340 ENOG4107RYR Transcriptional regulator, Crp Fnr family F0H33_18345 ENOG410635A Membrane F0H33_18360 ENOG4105DK0 Indole-3-glycerol phosphate synthase F0H33_18365 ENOG4108I0Q anthranilate phosphoribosyltransferase F0H33_18370 ENOG4105DDQ anthranilate synthase F0H33_18375 ENOG4105C5W Aldolase F0H33_18380 ENOG4105CRQ synthase (Component I) F0H33_18385 ENOG4107TE5 Lipid kinase F0H33_18400 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) F0H33_18405 ENOG4105C8V SAICAR synthetase F0H33_18415 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase F0H33_18420 ENOG4105D65 subunit l F0H33_18425 ENOG4108ZE9 Monovalent cation H antiporter subunit C F0H33_18430 ENOG4107R4Z monovalent cation h antiporter subunit d F0H33_18435 ENOG4105SC1 monovalent cation H antiporter subunit E F0H33_18440 ENOG4105W4C monovalent cation H antiporter subunit F F0H33_18445 ENOG4105KJM monovalent cation h antiporter subunit g F0H33_18450 ENOG4105FEU K -dependent Na -Ca exchanger F0H33_18490 ENOG4105DUX Transporter F0H33_18495 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) F0H33_18510 ENOG4107RUY (E1 component), alpha subunit F0H33_18515 ENOG4105CPP Dehydrogenase, E1 component F0H33_18525 ENOG4105C7S Dehydrogenase F0H33_18555 ENOG4105C1J atp-dependent rna helicase F0H33_18570 ENOG4105D7K pfkb domain protein F0H33_18575 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria F0H33_18580 ENOG4105CKW Inner membrane protein yedI F0H33_18605 ENOG4105EGS Mechanosensitive ion channel F0H33_18615 ENOG4105D6F Phosphatase F0H33_18630 ENOG4108KPJ rna polymerase sigma factor F0H33_18635 ENOG4105EUB pirin domain protein F0H33_18645 ENOG4105DRR Transcriptional regulator, GntR family F0H33_18660 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase F0H33_18665 ENOG41065ZS Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme- A to the apo- acyl-carrier-protein of the malonate decarboxylase to yield holo- acyl-carrier-protein (By similarity) F0H33_18685 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) F0H33_18695 ENOG4108K2P TRANSCRIPTIONal F0H33_18700 ENOG4105EDR glucose galactose transporter F0H33_18705 ENOG4105QJH Domain of unknown function (DUF718) F0H33_18710 ENOG4105DIA mandelate racemase muconate lactonizing F0H33_18715 ENOG4105ERH Fumarylacetoacetate hydrolase F0H33_18720 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr F0H33_18735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F0H33_18755 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F0H33_18760 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F0H33_18765 ENOG4105E98 transcriptional regulator DeoR family F0H33_18770 ENOG4108W15 Protein of unknown function (DUF1456) F0H33_18795 ENOG4105CNM Receptor F0H33_18800 ENOG4105CNM Receptor F0H33_18815 ENOG4105C5Z peptidase F0H33_18830 ENOG4105E0K tonB-dependent siderophore receptor F0H33_18875 ENOG4105C0H protease F0H33_18895 ENOG4105C02 permease F0H33_18900 ENOG4107URF beta-phospho-glucomutase F0H33_18905 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F0H33_18910 ENOG4107VGR Catalase F0H33_18935 ENOG4105C19 ABC transporter F0H33_18940 ENOG4107RBB ABC transporter, permease F0H33_18955 ENOG4105FR1 rard protein F0H33_18960 ENOG4105FDR Membrane F0H33_18975 ENOG4105C31 Tryptophanyl-tRNA synthetase F0H33_19015 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase F0H33_19025 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) F0H33_19045 ENOG4105EB3 Histidine kinase F0H33_19050 ENOG4105XJC Two component transcriptional regulator (Winged helix family F0H33_19060 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F0H33_19095 ENOG4106KE4 Dehydrogenase F0H33_19100 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0H33_19105 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) F0H33_19125 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F0H33_19130 ENOG4105D94 Major Facilitator Superfamily F0H33_19135 ENOG4106NZI LysR family Transcriptional regulator F0H33_19155 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F0H33_19160 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F0H33_19175 ENOG4108ZHJ Organic hydroperoxide resistance protein F0H33_19180 ENOG4105K56 Transcriptional regulator F0H33_19185 ENOG4105D6Z AFG1 family ATPase F0H33_19195 ENOG4108TZV Membrane F0H33_19205 ENOG4105CKI cobalamin synthesis protein F0H33_19215 ENOG4105KK4 UPF0060 membrane protein F0H33_19225 ENOG4105MPD Cytochrome F0H33_19235 ENOG4105C1G acyl-Coa dehydrogenase F0H33_19240 ENOG4107QX3 carboxylase F0H33_19270 ENOG4105CD5 CoA-binding domain protein F0H33_19275 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F0H33_19280 ENOG4105BZP glycoside hydrolase 15-related F0H33_19285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0H33_19300 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F0H33_19310 ENOG4105VNG YcgL domain-containing protein F0H33_19315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0H33_19325 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) F0H33_19335 ENOG4105C2D reductase F0H33_19360 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) F0H33_19375 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) F0H33_19400 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F0H33_19405 ENOG4105C4M (Ubiquinol oxidase) subunit I F0H33_19425 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) F0H33_19435 ENOG4107VMU Membrane F0H33_19440 ENOG4105C2M dna polymerase I F0H33_19455 ENOG4107YZX Universal stress protein F0H33_19475 ENOG4105C4R Atp-dependent dna helicase F0H33_19485 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F0H33_19490 ENOG4105W0E 50S ribosomal protein L33 F0H33_19495 ENOG4105KDC 50s ribosomal protein l28 F0H33_19525 ENOG4105CKK Glycosyl transferase, family 2 F0H33_19535 ENOG4105FA0 parb-like partition protein F0H33_19540 ENOG4107QJE Chromosome Partitioning Protein F0H33_19545 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) F0H33_19580 ENOG4107RGH Aldehyde dehydrogenase F0H33_19585 ENOG4105CSH Transporter F0H33_19595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F0H33_19605 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) F0H33_19610 ENOG4105BZU Histidine kinase F0H33_19625 ENOG4105E2V Glycosyltransferase 36 F0H33_19630 ENOG4105CT4 transporter F0H33_19640 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase F0H33_19650 ENOG4105MA0 exported protein F0H33_19655 ENOG4105CFU surface antigen F0H33_19675 ENOG4108YXG UPF0502 protein F0H33_19715 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) F0H33_19720 ENOG4105QV4 Tryptophan halogenase F0H33_19730 ENOG4105ETE Transcriptional regulator (LacI family F0H33_19740 ENOG4105E55 glycerol-3-phosphate acyltransferase F0H33_19760 ENOG4105DT9 hydrolase family 43 F0H33_19765 ENOG4105CT4 transporter F0H33_19790 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) F0H33_19825 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein F0H33_19840 ENOG4105DEI Mannitol dehydrogenase F0H33_19855 ENOG4105CXK mandelate racemase muconate lactonizing F0H33_19865 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) F0H33_19870 ENOG4105ETE Transcriptional regulator (LacI family F0H33_19875 ENOG4105C93 Xylose Isomerase F0H33_19880 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) F0H33_19885 ENOG4105DH7 May be involved in recombination (By similarity) F0H33_19905 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F0H33_19920 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) F0H33_19925 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F0H33_19935 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F0H33_19940 ENOG4107QHF type ii secretion system protein e F0H33_19945 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit F0H33_19960 ENOG4105C4R Atp-dependent dna helicase F0H33_19965 ENOG4107104 thymidine kinase F0H33_19975 ENOG4105DJ9 glucan biosynthesis protein F0H33_19985 ENOG4105D9P serine threonine protein kinase F0H33_20000 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) F0H33_20015 ENOG4105DKW ABC transporter F0H33_20030 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F0H33_20035 ENOG41067YR RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)