locus-tag	class	description
ISN37_00030	COG1064	alcohol dehydrogenase
ISN37_00035	COG2234	aminopeptidase activity
ISN37_00045	COG4942	peptidase
ISN37_00050	COG0793	Belongs to the peptidase S41A family
ISN37_00105	COG1565	acr, cog1565
ISN37_00105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN37_00110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN37_00115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN37_00150	COG0109	protoheme IX farnesyltransferase activity
ISN37_00165	COG0358	DNA primase activity
ISN37_00170	COG1295	ribonuclease BN
ISN37_00190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN37_00195	COG2308	Evidence 4 Homologs of previously reported genes of
ISN37_00210	COG2133	pyrroloquinoline quinone binding
ISN37_00230	COG0531	amino acid
ISN37_00240	COG4948	Mandelate Racemase Muconate Lactonizing
ISN37_00250	COG4771	TonB-dependent receptor
ISN37_00255	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISN37_00305	COG5383	Protein conserved in bacteria
ISN37_00320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN37_00325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN37_00340	COG1652	LysM domain
ISN37_00350	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN37_00355	COG1518	maintenance of DNA repeat elements
ISN37_00405	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN37_00415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN37_00420	COG3118	belongs to the thioredoxin family
ISN37_00430	COG2884	Cell division ATP-binding protein ftsE
ISN37_00435	COG2177	Part of the ABC transporter FtsEX involved in
ISN37_00440	COG2201	protein-glutamate methylesterase activity
ISN37_00445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN37_00450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN37_00455	COG2860	membrane
ISN37_00460	COG1252	NADH dehydrogenase
ISN37_00470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN37_00480	COG0534	Mate efflux family protein
ISN37_00485	COG0616	signal peptide processing
ISN37_00495	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_00510	COG0009	L-threonylcarbamoyladenylate synthase
ISN37_00515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN37_00515	COG1754	DNA topoisomerase type I activity
ISN37_00520	COG1714	RDD family
ISN37_00535	COG0758	DNA mediated transformation
ISN37_00540	COG1652	LysM domain
ISN37_00545	COG0242	peptide deformylase activity
ISN37_00550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN37_00555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN37_00555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN37_00560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN37_00595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN37_00600	COG1247	-acetyltransferase
ISN37_00610	COG1490	D-aminoacyl-tRNA deacylase activity
ISN37_00615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN37_00645	COG1609	Transcriptional regulator
ISN37_00655	COG0366	Alpha amylase catalytic
ISN37_00660	COG0366	Alpha amylase catalytic
ISN37_00710	COG1309	transcriptional regulator
ISN37_00750	COG0840	transmembrane signaling receptor activity
ISN37_00765	COG3546	catalase activity
ISN37_00770	COG3685	Protein conserved in bacteria
ISN37_00775	COG3685	Protein conserved in bacteria
ISN37_00780	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_00790	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN37_00805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN37_00820	COG0028	Belongs to the TPP enzyme family
ISN37_00825	COG4191	Histidine kinase
ISN37_00830	COG2204	response regulator
ISN37_00860	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN37_00865	COG0732	type I restriction modification DNA specificity domain
ISN37_00890	COG1648	precorrin-2 dehydrogenase activity
ISN37_00890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN37_00900	COG1116	anion transmembrane transporter activity
ISN37_00900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN37_00905	COG2223	nitrite transmembrane transporter activity
ISN37_00910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN37_00915	COG2146	nitrite reductase [NAD(P)H] activity
ISN37_00920	COG0243	molybdopterin cofactor binding
ISN37_00945	COG1640	4-alpha-glucanotransferase
ISN37_00950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN37_00995	COG0181	hydroxymethylbilane synthase activity
ISN37_01010	COG1733	regulation of RNA biosynthetic process
ISN37_01025	COG1505	serine-type exopeptidase activity
ISN37_01030	COG0436	Aminotransferase
ISN37_01040	COG2832	Protein of unknown function (DUF454)
ISN37_01050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN37_01070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISN37_01095	COG2226	methyltransferase
ISN37_01100	COG0308	aminopeptidase N
ISN37_01105	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN37_01105	COG0596	Alpha beta hydrolase
ISN37_01125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN37_01130	COG1077	Cell shape determining protein MreB Mrl
ISN37_01135	COG1792	Involved in formation and maintenance of cell shape
ISN37_01145	COG0768	penicillin binding
ISN37_01150	COG0772	Belongs to the SEDS family
ISN37_01165	COG2951	lytic endotransglycosylase activity
ISN37_01175	COG1686	Belongs to the peptidase S11 family
ISN37_01210	COG0321	lipoyl(octanoyl) transferase activity
ISN37_01215	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN37_01240	COG1056	cytidyltransferase-related domain
ISN37_01240	COG1051	belongs to the nudix hydrolase family
ISN37_01275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN37_01280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN37_01285	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN37_01290	COG1561	YicC-like family, N-terminal region
ISN37_01295	COG0194	GDP metabolic process
ISN37_01300	COG1758	RNA polymerase activity
ISN37_01305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN37_01325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN37_01340	COG0254	rRNA binding
ISN37_01345	COG0372	Belongs to the citrate synthase family
ISN37_01360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN37_01380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN37_01385	COG0667	Aldo Keto reductase
ISN37_01395	COG4771	TonB-dependent receptor
ISN37_01415	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN37_01420	COG4181	ATPase activity
ISN37_01435	COG0642	Histidine kinase
ISN37_01445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN37_01450	COG0861	Integral membrane protein TerC family
ISN37_01455	COG1704	LemA family
ISN37_01500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN37_01510	COG1215	transferase activity, transferring glycosyl groups
ISN37_01535	COG0242	peptide deformylase activity
ISN37_01545	COG0488	(ABC) transporter
ISN37_01550	COG0477	Major facilitator Superfamily
ISN37_01580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN37_01590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN37_01590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN37_01605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN37_01610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN37_01615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN37_01640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN37_01645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN37_01655	COG2205	protein histidine kinase activity
ISN37_01660	COG0745	RESPONSE REGULATOR receiver
ISN37_01665	COG0277	FAD linked oxidase domain protein
ISN37_01675	COG0792	nuclease activity
ISN37_01710	COG2001	Belongs to the MraZ family
ISN37_01715	COG0275	rRNA processing
ISN37_01720	COG3116	cell division
ISN37_01735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN37_01760	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN37_01765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN37_01775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN37_01780	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN37_01790	COG0739	heme binding
ISN37_01805	COG0494	nUDIX hydrolase
ISN37_01815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN37_01840	COG2226	methyltransferase
ISN37_01880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN37_01895	COG1090	epimerase
ISN37_01910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN37_01915	COG0673	inositol 2-dehydrogenase activity
ISN37_01920	COG2823	Periplasmic or secreted lipoprotein
ISN37_01930	COG2205	protein histidine kinase activity
ISN37_01930	COG2202	Pas domain
ISN37_01935	COG0784	Response regulator, receiver
ISN37_01940	COG4191	Histidine kinase
ISN37_01950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN37_01985	COG3250	beta-galactosidase activity
ISN37_02000	COG2188	Transcriptional regulator
ISN37_02005	COG0738	Major facilitator superfamily
ISN37_02010	COG1609	Transcriptional regulator
ISN37_02015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN37_02020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN37_02025	COG0617	tRNA 3'-terminal CCA addition
ISN37_02100	COG2205	protein histidine kinase activity
ISN37_02115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN37_02120	COG3791	Glutathione-dependent formaldehyde-activating
ISN37_02160	COG0804	urea catabolic process
ISN37_02165	COG1228	amidohydrolase
ISN37_02185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN37_02210	COG0436	Aminotransferase
ISN37_02215	COG1162	GTPase activity
ISN37_02240	COG2211	Major facilitator Superfamily
ISN37_02250	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_02255	COG2851	Citrate transporter
ISN37_02270	COG0642	Histidine kinase
ISN37_02290	COG4191	Histidine kinase
ISN37_02300	COG1301	dicarboxylic acid transport
ISN37_02305	COG0281	malic enzyme
ISN37_02305	COG0280	phosphate acetyltransferase
ISN37_02390	COG1560	Kdo2-lipid A biosynthetic process
ISN37_02395	COG1519	Transferase
ISN37_02400	COG1538	Outer membrane efflux protein
ISN37_02405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN37_02415	COG3706	GGDEF domain
ISN37_02420	COG0473	3-isopropylmalate dehydrogenase activity
ISN37_02425	COG0066	3-isopropylmalate dehydratase activity
ISN37_02435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN37_02445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN37_02465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN37_02470	COG0840	transmembrane signaling receptor activity
ISN37_02490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN37_02500	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN37_02520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN37_02530	COG0671	phosphoesterase, PA-phosphatase related
ISN37_02545	COG1940	carbohydrate kinase activity
ISN37_02555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN37_02595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN37_02610	COG1773	rubredoxin
ISN37_02625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN37_02635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN37_02660	COG3079	Belongs to the UPF0149 family
ISN37_02665	COG0006	proline dipeptidase activity
ISN37_02685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN37_02715	COG0714	Associated with various cellular activities
ISN37_02750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN37_02775	COG0739	heme binding
ISN37_02780	COG1376	ErfK ybiS ycfS ynhG family protein
ISN37_02805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN37_02810	COG4149	molybdate abc transporter
ISN37_02815	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN37_02825	COG0640	Transcriptional regulator
ISN37_02845	COG3047	cAMP biosynthetic process
ISN37_02850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN37_02895	COG0469	pyruvate kinase activity
ISN37_02900	COG3588	fructose-bisphosphate aldolase
ISN37_02905	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN37_02945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN37_02960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN37_02960	COG1648	precorrin-2 dehydrogenase activity
ISN37_02975	COG2205	protein histidine kinase activity
ISN37_02975	COG0784	Response regulator, receiver
ISN37_02975	COG2198	Histidine kinase
ISN37_02980	COG1393	Belongs to the ArsC family
ISN37_03010	COG0175	sulfate reduction
ISN37_03015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN37_03020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN37_03030	COG2895	sulfate adenylyltransferase (ATP) activity
ISN37_03030	COG0529	Catalyzes the synthesis of activated sulfate
ISN37_03035	COG0840	transmembrane signaling receptor activity
ISN37_03075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN37_03095	COG1609	Transcriptional regulator
ISN37_03110	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN37_03125	COG0471	metal ion transport
ISN37_03125	COG3273	potassium ion transport
ISN37_03135	COG2022	thiamine diphosphate biosynthetic process
ISN37_03160	COG0174	glutamine synthetase
ISN37_03165	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN37_03175	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN37_03190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN37_03215	COG3511	phospholipase C
ISN37_03225	COG0189	ligase activity
ISN37_03235	COG0745	RESPONSE REGULATOR receiver
ISN37_03250	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN37_03315	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN37_03315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN37_03325	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN37_03340	COG1174	glycine betaine transport
ISN37_03345	COG1125	glycine betaine transport
ISN37_03355	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN37_03360	COG0564	pseudouridine synthase activity
ISN37_03380	COG4993	Dehydrogenase
ISN37_03395	COG3387	PFAM Glycoside hydrolase 15-related
ISN37_03420	COG0454	-acetyltransferase
ISN37_03445	COG0542	response to heat
ISN37_03470	COG0019	diaminopimelate decarboxylase activity
ISN37_03475	COG4264	IucA IucC family
ISN37_03480	COG2814	Major facilitator Superfamily
ISN37_03485	COG4264	IucA IucC family
ISN37_03495	COG4772	TonB-dependent receptor
ISN37_03505	COG4651	solute:proton antiporter activity
ISN37_03505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN37_03555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN37_03555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN37_03575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN37_03615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN37_03620	COG1404	Belongs to the peptidase S8 family
ISN37_03655	COG1295	ribonuclease BN
ISN37_03660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN37_03680	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN37_03785	COG3209	COG3209 Rhs family protein
ISN37_03840	COG4682	membrane
ISN37_03930	COG3179	chitinase
ISN37_04085	COG3537	Alpha-1,2-mannosidase
ISN37_04105	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN37_04115	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN37_04120	COG1388	LysM domain
ISN37_04120	COG3858	chitin binding
ISN37_04140	COG0837	glucose binding
ISN37_04150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN37_04160	COG0494	nUDIX hydrolase
ISN37_04165	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN37_04170	COG3956	TIGRFAM MazG family protein
ISN37_04175	COG1742	UPF0060 membrane protein
ISN37_04185	COG0330	HflC and HflK could
ISN37_04260	COG2124	cytochrome p450
ISN37_04265	COG2124	cytochrome p450
ISN37_04270	COG1141	Ferredoxin
ISN37_04275	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_04280	COG2124	cytochrome p450
ISN37_04285	COG0142	geranyltranstransferase activity
ISN37_04290	COG1657	PFAM Prenyltransferase squalene oxidase
ISN37_04300	COG1304	FMN binding
ISN37_04335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN37_04340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN37_04345	COG0463	Glycosyl transferase, family 2
ISN37_04350	COG0517	IMP dehydrogenase activity
ISN37_04355	COG2982	Protein involved in outer membrane biogenesis
ISN37_04360	COG1272	protein, Hemolysin III
ISN37_04365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN37_04375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN37_04380	COG0626	cystathionine gamma-synthase activity
ISN37_04385	COG0460	homoserine dehydrogenase
ISN37_04385	COG0527	aspartate kinase activity
ISN37_04390	COG2267	carboxylic ester hydrolase activity
ISN37_04400	COG1760	l-serine dehydratase
ISN37_04415	COG3038	cytochrome b561
ISN37_04435	COG2814	Major facilitator Superfamily
ISN37_04440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN37_04450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN37_04470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN37_04475	COG0259	pyridoxamine-phosphate oxidase activity
ISN37_04515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISN37_04530	COG0519	Catalyzes the synthesis of GMP from XMP
ISN37_04545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN37_04570	COG0840	transmembrane signaling receptor activity
ISN37_04580	COG1113	amino acid transport
ISN37_04600	COG2239	Acts as a magnesium transporter
ISN37_04605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN37_04610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN37_04620	COG1660	Displays ATPase and GTPase activities
ISN37_04630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN37_04645	COG1137	ATPase activity
ISN37_04660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN37_04705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN37_04730	COG0628	permease
ISN37_04740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN37_04745	COG3178	'Phosphotransferase
ISN37_04760	COG1555	photosystem II stabilization
ISN37_04780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN37_04785	COG1477	protein flavinylation
ISN37_04810	COG4774	siderophore transport
ISN37_04815	COG2146	nitrite reductase [NAD(P)H] activity
ISN37_04825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN37_04830	COG0719	Fe-S assembly protein
ISN37_04835	COG0396	ATPase activity
ISN37_04840	COG0719	Fe-S assembly protein
ISN37_04855	COG0693	protein deglycase activity
ISN37_04870	COG0739	heme binding
ISN37_04885	COG1764	response to oxidative stress
ISN37_04895	COG0384	phenazine biosynthesis protein PhzF
ISN37_04900	COG0527	aspartate kinase activity
ISN37_04925	COG0142	geranyltranstransferase activity
ISN37_04930	COG0629	single-stranded DNA binding
ISN37_04950	COG3104	oligopeptide transport
ISN37_04955	COG1297	OPT oligopeptide transporter protein
ISN37_04960	COG1506	peptidase
ISN37_04960	COG0823	Involved in the tonB-independent uptake of proteins
ISN37_04985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN37_04990	COG2879	small protein
ISN37_04995	COG1966	Carbon starvation protein
ISN37_05030	COG2211	Major facilitator Superfamily
ISN37_05040	COG2801	Transposase and inactivated derivatives
ISN37_05065	COG0835	chemotaxis
ISN37_05070	COG0840	transmembrane signaling receptor activity
ISN37_05075	COG0840	transmembrane signaling receptor activity
ISN37_05080	COG0840	transmembrane signaling receptor activity
ISN37_05085	COG0643	Histidine kinase
ISN37_05085	COG2198	Histidine kinase
ISN37_05095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN37_05115	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN37_05125	COG2205	protein histidine kinase activity
ISN37_05160	COG0735	belongs to the Fur family
ISN37_05200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN37_05205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN37_05210	COG2080	2 iron, 2 sulfur cluster binding
ISN37_05320	COG1187	pseudouridine synthase activity
ISN37_05345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN37_05365	COG1132	(ABC) transporter
ISN37_05460	COG1981	membrane
ISN37_05485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN37_05490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN37_05500	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN37_05510	COG0750	zinc metalloprotease
ISN37_05515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN37_05520	COG0575	Belongs to the CDS family
ISN37_05525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN37_05535	COG0528	UMP kinase activity
ISN37_05545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN37_05585	COG0024	Methionine aminopeptidase
ISN37_05600	COG1393	Belongs to the ArsC family
ISN37_05605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN37_05615	COG0367	asparagine synthase
ISN37_05655	COG1566	PFAM secretion protein HlyD family protein
ISN37_05660	COG2814	Major facilitator Superfamily
ISN37_05695	COG0557	exoribonuclease II activity
ISN37_05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN37_05725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN37_05745	COG0704	Plays a role in the regulation of phosphate uptake
ISN37_05755	COG0581	inorganic phosphate transmembrane transporter activity
ISN37_05765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN37_05770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN37_05790	COG0659	secondary active sulfate transmembrane transporter activity
ISN37_05800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN37_05810	COG1024	Enoyl-CoA hydratase
ISN37_05870	COG2205	protein histidine kinase activity
ISN37_05870	COG5002	protein histidine kinase activity
ISN37_05870	COG0784	Response regulator, receiver
ISN37_05875	COG2733	membrane
ISN37_05895	COG0686	Belongs to the AlaDH PNT family
ISN37_05900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN37_05905	COG1917	Cupin 2, conserved barrel domain protein
ISN37_05905	COG1396	sequence-specific DNA binding
ISN37_05910	COG1012	belongs to the aldehyde dehydrogenase family
ISN37_05930	COG2223	nitrite transmembrane transporter activity
ISN37_05940	COG0243	molybdopterin cofactor binding
ISN37_05965	COG0477	Major facilitator Superfamily
ISN37_05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN37_05980	COG0174	glutamine synthetase
ISN37_05985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN37_05990	COG0174	glutamine synthetase
ISN37_06005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN37_06025	COG3842	ATPase activity
ISN37_06030	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN37_06035	COG1177	transmembrane transport
ISN37_06040	COG1012	belongs to the aldehyde dehydrogenase family
ISN37_06055	COG4535	Mg2 and Co2 transporter CorC
ISN37_06070	COG1702	phosphate starvation-inducible protein PhoH
ISN37_06085	COG0741	lytic transglycosylase activity
ISN37_06090	COG0723	plastoquinol--plastocyanin reductase activity
ISN37_06095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN37_06105	COG2857	Cytochrome c1
ISN37_06110	COG0625	glutathione transferase activity
ISN37_06115	COG2969	positive regulation of protein catabolic process
ISN37_06155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN37_06160	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_06165	COG2095	MarC family integral membrane protein
ISN37_06175	COG1611	Belongs to the LOG family
ISN37_06180	COG3275	phosphorelay sensor kinase activity
ISN37_06225	COG0556	nucleotide-excision repair
ISN37_06240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN37_06245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN37_06255	COG2902	Dehydrogenase
ISN37_06310	COG2925	Exonuclease
ISN37_06320	COG3844	kynureninase activity
ISN37_06330	COG0662	Cupin 2, conserved barrel domain protein
ISN37_06335	COG0288	reversible hydration of carbon dioxide
ISN37_06380	COG2197	response regulator
ISN37_06405	COG0316	Belongs to the HesB IscA family
ISN37_06440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN37_06445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN37_06450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN37_06460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN37_06480	COG1309	transcriptional regulator
ISN37_06495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN37_06510	COG1228	amidohydrolase
ISN37_06525	COG4221	oxidoreductase activity
ISN37_06565	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN37_06570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN37_06575	COG1605	Chorismate mutase
ISN37_06575	COG0077	Prephenate dehydratase
ISN37_06600	COG0583	DNA-binding transcription factor activity
ISN37_06650	COG1136	(ABC) transporter
ISN37_06650	COG0577	efflux transmembrane transporter activity
ISN37_06680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN37_06680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN37_06685	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN37_06690	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN37_06690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN37_06695	COG1609	Transcriptional regulator
ISN37_06705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN37_06710	COG0069	glutamate synthase activity
ISN37_06745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN37_06760	COG1253	flavin adenine dinucleotide binding
ISN37_06770	COG0306	phosphate transporter
ISN37_06815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN37_06820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN37_06835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN37_06845	COG1238	metal cluster binding
ISN37_06860	COG1534	Rna-binding protein
ISN37_06865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN37_06870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN37_06875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN37_06880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN37_06890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN37_06895	COG1546	Belongs to the CinA family
ISN37_06900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN37_06905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN37_06910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN37_06915	COG2137	regulation of response to DNA damage stimulus
ISN37_06925	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISN37_06950	COG1741	Belongs to the pirin family
ISN37_06955	COG0583	DNA-binding transcription factor activity
ISN37_06975	COG0351	phosphomethylpyrimidine kinase
ISN37_06975	COG0352	thiamine-phosphate diphosphorylase activity
ISN37_07020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN37_07025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN37_07035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN37_07045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN37_07050	COG3734	2-keto-3-deoxy-galactonokinase
ISN37_07065	COG0800	Aldolase
ISN37_07100	COG2205	protein histidine kinase activity
ISN37_07100	COG2198	Histidine kinase
ISN37_07100	COG0784	Response regulator, receiver
ISN37_07105	COG1024	Enoyl-CoA hydratase
ISN37_07110	COG0318	PFAM AMP-dependent synthetase and ligase
ISN37_07175	COG0840	transmembrane signaling receptor activity
ISN37_07185	COG0840	transmembrane signaling receptor activity
ISN37_07195	COG0835	chemotaxis
ISN37_07205	COG0840	transmembrane signaling receptor activity
ISN37_07215	COG0840	transmembrane signaling receptor activity
ISN37_07220	COG0840	transmembrane signaling receptor activity
ISN37_07225	COG0840	transmembrane signaling receptor activity
ISN37_07235	COG0840	transmembrane signaling receptor activity
ISN37_07245	COG0840	transmembrane signaling receptor activity
ISN37_07250	COG0840	transmembrane signaling receptor activity
ISN37_07255	COG0840	transmembrane signaling receptor activity
ISN37_07260	COG0840	transmembrane signaling receptor activity
ISN37_07270	COG0745	RESPONSE REGULATOR receiver
ISN37_07280	COG0835	chemotaxis
ISN37_07285	COG1192	Involved in chromosome partitioning
ISN37_07295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN37_07300	COG0643	Histidine kinase
ISN37_07300	COG2198	Histidine kinase
ISN37_07300	COG0784	Response regulator, receiver
ISN37_07305	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN37_07350	COG1684	flagellar biosynthetic protein fliR
ISN37_07355	COG1987	bacterial-type flagellum assembly
ISN37_07365	COG3190	flagellar
ISN37_07415	COG1677	Flagellar hook-basal body complex protein FliE
ISN37_07450	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_07460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN37_07480	COG2201	protein-glutamate methylesterase activity
ISN37_07490	COG2197	response regulator
ISN37_07510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN37_07515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN37_07525	COG4786	Flagellar basal body rod
ISN37_07525	COG1256	bacterial-type flagellum assembly
ISN37_07525	COG1256	bacterial-type flagellum assembly
ISN37_07525	COG4786	Flagellar basal body rod
ISN37_07540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN37_07555	COG1749	Flagellar hook protein flgE
ISN37_07565	COG1558	bacterial-type flagellum-dependent cell motility
ISN37_07575	COG0784	Response regulator, receiver
ISN37_07575	COG0835	chemotaxis
ISN37_07635	COG2915	High frequency lysogenization protein hflD homolog
ISN37_07640	COG0482	sulfurtransferase activity
ISN37_07660	COG0542	response to heat
ISN37_07670	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISN37_07680	COG0492	ferredoxin-NADP+ reductase activity
ISN37_07685	COG1674	ftsk spoiiie
ISN37_07705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN37_07710	COG0038	chloride channel
ISN37_07765	COG1595	DNA-templated transcription, initiation
ISN37_07785	COG3038	cytochrome b561
ISN37_07815	COG2244	polysaccharide biosynthetic process
ISN37_07835	COG4106	trans-aconitate 2-methyltransferase activity
ISN37_07855	COG0438	transferase activity, transferring glycosyl groups
ISN37_07860	COG0438	transferase activity, transferring glycosyl groups
ISN37_07885	COG1132	(ABC) transporter
ISN37_07910	COG1530	ribonuclease E activity
ISN37_07925	COG0428	transporter
ISN37_07940	COG0316	Belongs to the HesB IscA family
ISN37_07940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN37_07960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN37_07980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN37_07985	COG2957	Belongs to the agmatine deiminase family
ISN37_07995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN37_08000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN37_08005	COG0539	negative regulation of cytoplasmic translation
ISN37_08010	COG0776	regulation of translation
ISN37_08020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN37_08025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN37_08035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN37_08040	COG0183	Belongs to the thiolase family
ISN37_08045	COG1024	Enoyl-CoA hydratase
ISN37_08045	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN37_08060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN37_08070	COG1426	Protein conserved in bacteria
ISN37_08080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN37_08090	COG0746	molybdenum cofactor guanylyltransferase activity
ISN37_08100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN37_08105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN37_08105	COG0475	glutathione-regulated potassium exporter activity
ISN37_08125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN37_08135	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN37_08135	COG0519	Catalyzes the synthesis of GMP from XMP
ISN37_08140	COG0582	viral genome integration into host DNA
ISN37_08170	COG2801	Transposase and inactivated derivatives
ISN37_08255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN37_08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN37_08270	COG0505	Belongs to the CarA family
ISN37_08280	COG2258	MOSC domain
ISN37_08285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN37_08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN37_08315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN37_08320	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN37_08355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN37_08370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN37_08380	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN37_08385	COG1132	(ABC) transporter
ISN37_08395	COG0811	peptide transport
ISN37_08415	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN37_08425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN37_08430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISN37_08440	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN37_08445	COG2009	succinate dehydrogenase
ISN37_08465	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN37_08480	COG0129	dihydroxy-acid dehydratase activity
ISN37_08495	COG0395	ABC-type sugar transport system, permease component
ISN37_08530	COG2350	Protein conserved in bacteria
ISN37_08535	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN37_08540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN37_08545	COG1187	pseudouridine synthase activity
ISN37_08570	COG0436	Aminotransferase
ISN37_08575	COG4133	protoheme IX ABC transporter activity
ISN37_08620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN37_08625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN37_08630	COG4988	ABC transporter
ISN37_08640	COG1294	oxidase, subunit
ISN37_08670	COG2801	Transposase and inactivated derivatives
ISN37_08675	COG2963	transposase activity
ISN37_08690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN37_08695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN37_08710	COG1024	Enoyl-CoA hydratase
ISN37_08720	COG1024	Enoyl-CoA hydratase
ISN37_08725	COG1024	Enoyl-CoA hydratase
ISN37_08765	COG0346	lactoylglutathione lyase activity
ISN37_08775	COG1304	FMN binding
ISN37_08780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN37_08785	COG1649	PFAM Uncharacterised BCR, COG1649
ISN37_08915	COG1196	nuclear chromosome segregation
ISN37_08990	COG5410	chromosome segregation
ISN37_08995	COG5484	DNA packaging
ISN37_08995	COG3728	DNA packaging
ISN37_09065	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN37_09080	COG0305	Participates in initiation and elongation during chromosome replication
ISN37_09245	COG2205	protein histidine kinase activity
ISN37_09245	COG0784	Response regulator, receiver
ISN37_09250	COG2183	response to ionizing radiation
ISN37_09255	COG0784	Response regulator, receiver
ISN37_09255	COG4191	Histidine kinase
ISN37_09265	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN37_09265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN37_09285	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN37_09295	COG1183	phosphatidylcholine synthase activity
ISN37_09300	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_09315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN37_09325	COG0668	transmembrane transport
ISN37_09330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN37_09345	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN37_09355	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN37_09360	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN37_09365	COG2963	transposase activity
ISN37_09420	COG1487	ribonuclease activity
ISN37_09425	COG4691	Plasmid stability protein
ISN37_09455	COG1960	acyl-CoA dehydrogenase activity
ISN37_09460	COG2226	methyltransferase
ISN37_09465	COG0646	methionine synthase
ISN37_09465	COG1410	methionine synthase
ISN37_09470	COG0646	methionine synthase
ISN37_09470	COG1410	methionine synthase
ISN37_09490	COG2900	Belongs to the SlyX family
ISN37_09505	COG0386	Belongs to the glutathione peroxidase family
ISN37_09515	COG1725	Transcriptional regulator
ISN37_09520	COG1131	(ABC) transporter
ISN37_09565	COG2885	chlorophyll binding
ISN37_09570	COG2850	peptidyl-arginine hydroxylation
ISN37_09620	COG1132	(ABC) transporter
ISN37_09630	COG0287	Prephenate dehydrogenase
ISN37_09630	COG1605	Chorismate mutase
ISN37_09635	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN37_09640	COG0484	heat shock protein binding
ISN37_09645	COG0443	Heat shock 70 kDa protein
ISN37_09650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN37_09655	COG1420	regulation of RNA biosynthetic process
ISN37_09660	COG0497	DNA recombination
ISN37_09665	COG0735	belongs to the Fur family
ISN37_09670	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN37_09680	COG2867	negative regulation of translational initiation
ISN37_09685	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN37_09690	COG1404	Belongs to the peptidase S8 family
ISN37_09725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN37_09740	COG0583	DNA-binding transcription factor activity
ISN37_09755	COG0415	Belongs to the DNA photolyase family
ISN37_09760	COG0305	Participates in initiation and elongation during chromosome replication
ISN37_09770	COG1960	acyl-CoA dehydrogenase activity
ISN37_09785	COG0084	hydrolase, TatD family'
ISN37_09790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN37_09840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISN37_09865	COG0386	Belongs to the glutathione peroxidase family
ISN37_09880	COG1846	Transcriptional regulator
ISN37_09920	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN37_09930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN37_09935	COG4290	ribonuclease
ISN37_09945	COG0488	(ABC) transporter
ISN37_09950	COG0513	Belongs to the DEAD box helicase family
ISN37_09975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN37_09980	COG0657	acetylesterase activity
ISN37_09985	COG0625	glutathione transferase activity
ISN37_09995	COG0564	pseudouridine synthase activity
ISN37_10000	COG4681	YaeQ
ISN37_10005	COG2081	HI0933 family
ISN37_10025	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_10045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN37_10050	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN37_10055	COG0802	atpase or kinase
ISN37_10060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN37_10060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN37_10065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN37_10110	COG1960	acyl-CoA dehydrogenase activity
ISN37_10120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN37_10140	COG0438	transferase activity, transferring glycosyl groups
ISN37_10150	COG0438	transferase activity, transferring glycosyl groups
ISN37_10155	COG0438	transferase activity, transferring glycosyl groups
ISN37_10205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN37_10210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN37_10220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN37_10255	COG1024	Enoyl-CoA hydratase
ISN37_10270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN37_10290	COG0277	FAD linked oxidase domain protein
ISN37_10295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN37_10310	COG0531	amino acid
ISN37_10315	COG0531	amino acid
ISN37_10320	COG0235	Class ii aldolase
ISN37_10325	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN37_10330	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN37_10350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN37_10350	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN37_10365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN37_10380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN37_10385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN37_10395	COG0124	histidyl-tRNA synthetase
ISN37_10400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN37_10410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN37_10420	COG2951	lytic endotransglycosylase activity
ISN37_10425	COG0083	homoserine kinase activity
ISN37_10430	COG0460	homoserine dehydrogenase
ISN37_10430	COG0527	aspartate kinase activity
ISN37_10445	COG1012	belongs to the aldehyde dehydrogenase family
ISN37_10460	COG0167	dihydroorotate dehydrogenase activity
ISN37_10465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN37_10490	COG0671	phosphoesterase, PA-phosphatase related
ISN37_10505	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN37_10575	COG0166	Belongs to the GPI family
ISN37_10590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN37_10600	COG0617	tRNA 3'-terminal CCA addition
ISN37_10620	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN37_10625	COG0477	Major facilitator Superfamily
ISN37_10630	COG2115	Belongs to the xylose isomerase family
ISN37_10635	COG1070	Carbohydrate kinase
ISN37_10655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN37_10675	COG0165	Argininosuccinate lyase
ISN37_10680	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN37_10690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN37_10695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN37_10700	COG0137	argininosuccinate synthase activity
ISN37_10705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN37_10720	COG2166	iron-sulfur cluster assembly
ISN37_10790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN37_10830	COG0402	S-adenosylhomocysteine deaminase activity
ISN37_10835	COG3548	integral membrane protein
ISN37_10845	COG1509	lysine 2,3-aminomutase activity
ISN37_10850	COG5001	Diguanylate cyclase
ISN37_10850	COG3706	GGDEF domain
ISN37_10850	COG2203	Gaf domain
ISN37_10850	COG4251	negative regulation of phosphorylation
ISN37_10875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN37_10880	COG1862	Preprotein translocase
ISN37_10890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN37_10900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN37_10910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN37_10915	COG3291	Pkd domain containing protein
ISN37_10920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN37_10925	COG0405	Gamma-glutamyltransferase
ISN37_10930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN37_10945	COG0742	ribosomal rna small subunit methyltransferase
ISN37_10970	COG4771	TonB-dependent receptor
ISN37_10980	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN37_11015	COG0531	amino acid
ISN37_11030	COG0006	proline dipeptidase activity
ISN37_11040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN37_11055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN37_11060	COG3938	Belongs to the proline racemase family
ISN37_11070	COG0552	protein localization to endoplasmic reticulum
ISN37_11075	COG1194	a g-specific adenine glycosylase
ISN37_11125	COG0835	chemotaxis
ISN37_11130	COG0840	transmembrane signaling receptor activity
ISN37_11135	COG0840	transmembrane signaling receptor activity
ISN37_11155	COG5001	Diguanylate cyclase
ISN37_11155	COG3300	MHYT domain
ISN37_11160	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN37_11185	COG0195	Participates in both transcription termination and antitermination
ISN37_11200	COG1007	ATP synthesis coupled electron transport
ISN37_11235	COG1034	ATP synthesis coupled electron transport
ISN37_11240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN37_11245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN37_11250	COG0649	NAD binding
ISN37_11255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN37_11265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN37_11285	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_11310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN37_11355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISN37_11370	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN37_11380	COG0688	phosphatidylethanolamine metabolic process
ISN37_11385	COG0741	lytic transglycosylase activity
ISN37_11390	COG0433	COG0433 Predicted ATPase
ISN37_11395	COG0494	nUDIX hydrolase
ISN37_11410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN37_11430	COG1714	RDD family
ISN37_11435	COG0717	Belongs to the dCTP deaminase family
ISN37_11440	COG0489	protein tyrosine kinase activity
ISN37_11450	COG4771	TonB-dependent receptor
ISN37_11455	COG4771	TonB-dependent receptor
ISN37_11460	COG0457	Tetratricopeptide repeat
ISN37_11475	COG3590	peptidase
ISN37_11525	COG0697	spore germination
ISN37_11545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN37_11550	COG2311	Membrane
ISN37_11555	COG1047	Peptidyl-prolyl cis-trans
ISN37_11560	COG0791	NLP P60 protein
ISN37_11565	COG0791	NLP P60 protein
ISN37_11580	COG1607	acyl-coa hydrolase
ISN37_11590	COG1301	dicarboxylic acid transport
ISN37_11595	COG1785	Belongs to the alkaline phosphatase family
ISN37_11605	COG0037	tRNA processing
ISN37_11610	COG1722	exodeoxyribonuclease VII activity
ISN37_11615	COG0142	geranyltranstransferase activity
ISN37_11625	COG1858	cytochrome C peroxidase
ISN37_11650	COG2815	serine threonine protein kinase
ISN37_11650	COG0515	serine threonine protein kinase
ISN37_11655	COG0631	protein serine/threonine phosphatase activity
ISN37_11745	COG0312	modulator of DNA gyrase
ISN37_11755	COG0312	modulator of DNA gyrase
ISN37_11775	COG2968	Membrane
ISN37_11790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN37_11805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN37_11820	COG0495	leucyl-tRNA aminoacylation
ISN37_11830	COG3118	belongs to the thioredoxin family
ISN37_11850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN37_11860	COG2040	homocysteine
ISN37_11865	COG0833	amino acid
ISN37_11875	COG0346	lactoylglutathione lyase activity
ISN37_11900	COG2878	Part of a membrane complex involved in electron transport
ISN37_11915	COG1595	DNA-templated transcription, initiation
ISN37_11940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN37_11960	COG0251	oxidation-reduction process
ISN37_11970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN37_11970	COG0392	lysyltransferase activity
ISN37_12000	COG2814	Major facilitator Superfamily
ISN37_12010	COG1902	pentaerythritol trinitrate reductase activity
ISN37_12015	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN37_12020	COG1047	Peptidyl-prolyl cis-trans
ISN37_12025	COG1077	Cell shape determining protein MreB Mrl
ISN37_12060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN37_12070	COG1451	nucleotide metabolic process
ISN37_12095	COG2205	protein histidine kinase activity
ISN37_12095	COG0784	Response regulator, receiver
ISN37_12095	COG2198	Histidine kinase
ISN37_12105	COG2186	Transcriptional regulator
ISN37_12110	COG3250	beta-galactosidase activity
ISN37_12175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN37_12175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN37_12175	COG1703	isobutyryl-CoA mutase activity
ISN37_12210	COG0183	Belongs to the thiolase family
ISN37_12220	COG0443	Heat shock 70 kDa protein
ISN37_12250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN37_12250	COG1793	dna ligase
ISN37_12255	COG1793	dna ligase
ISN37_12255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN37_12260	COG1201	RNA secondary structure unwinding
ISN37_12270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN37_12275	COG1278	Cold shock
ISN37_12280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN37_12285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN37_12290	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN37_12295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISN37_12300	COG2954	triphosphatase activity
ISN37_12310	COG0745	RESPONSE REGULATOR receiver
ISN37_12320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN37_12335	COG0681	Belongs to the peptidase S26 family
ISN37_12340	COG0481	GTPase activity
ISN37_12345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN37_12375	COG2855	membrane
ISN37_12390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN37_12410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN37_12420	COG0534	Mate efflux family protein
ISN37_12425	COG0335	large ribosomal subunit rRNA binding
ISN37_12430	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN37_12435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN37_12450	COG2070	2-Nitropropane dioxygenase
ISN37_12455	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN37_12480	COG0475	glutathione-regulated potassium exporter activity
ISN37_12490	COG0625	glutathione transferase activity
ISN37_12495	COG1082	Xylose isomerase domain protein TIM barrel
ISN37_12505	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN37_12510	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN37_12515	COG1129	ABC transporter
ISN37_12520	COG1879	ABC-type sugar transport system periplasmic component
ISN37_12525	COG1012	belongs to the aldehyde dehydrogenase family
ISN37_12545	COG0129	dihydroxy-acid dehydratase activity
ISN37_12570	COG2207	Transcriptional regulator
ISN37_12590	COG1317	bacterial-type flagellum organization
ISN37_12615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN37_12640	COG4794	Type iii secretion
ISN37_12670	COG0745	RESPONSE REGULATOR receiver
ISN37_12700	COG3152	Membrane
ISN37_12710	COG0156	8-amino-7-oxononanoate synthase activity
ISN37_12720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN37_12725	COG1845	cytochrome c oxidase, subunit III
ISN37_12730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN37_12750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN37_12765	COG0196	riboflavin kinase activity
ISN37_12790	COG0728	peptidoglycan biosynthetic process
ISN37_12810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN37_12815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN37_12820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN37_12825	COG0824	Thioesterase
ISN37_12835	COG1024	Enoyl-CoA hydratase
ISN37_12840	COG1946	Acyl-CoA thioesterase
ISN37_12850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN37_12855	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN37_12920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN37_12965	COG1643	Atp-dependent helicase
ISN37_12970	COG0783	Belongs to the Dps family
ISN37_12975	COG0514	ATP-dependent DNA helicase (RecQ)
ISN37_12995	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN37_13000	COG0602	queuosine metabolic process
ISN37_13010	COG2885	chlorophyll binding
ISN37_13025	COG0848	biopolymer transport protein
ISN37_13035	COG0824	Thioesterase
ISN37_13040	COG2255	four-way junction helicase activity
ISN37_13045	COG3158	transport of potassium into the cell
ISN37_13050	COG0632	four-way junction helicase activity
ISN37_13060	COG0217	transcriptional regulatory protein
ISN37_13100	COG3142	Participates in the control of copper homeostasis
ISN37_13105	COG1446	asparaginase
ISN37_13125	COG2201	protein-glutamate methylesterase activity
ISN37_13130	COG2198	Histidine kinase
ISN37_13130	COG0784	Response regulator, receiver
ISN37_13130	COG0643	Histidine kinase
ISN37_13135	COG0840	transmembrane signaling receptor activity
ISN37_13140	COG0835	chemotaxis
ISN37_13155	COG0189	ligase activity
ISN37_13175	COG1199	ATP-dependent helicase activity
ISN37_13185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN37_13190	COG1216	Glycosyl transferase, family 2
ISN37_13195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISN37_13215	COG4585	Histidine kinase
ISN37_13225	COG0850	regulation of cytokinetic process
ISN37_13230	COG2894	cell division
ISN37_13235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN37_13245	COG2205	protein histidine kinase activity
ISN37_13250	COG0745	RESPONSE REGULATOR receiver
ISN37_13260	COG2194	sulfuric ester hydrolase activity
ISN37_13280	COG2814	Major facilitator Superfamily
ISN37_13305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN37_13305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN37_13315	COG0753	catalase activity
ISN37_13325	COG4106	trans-aconitate 2-methyltransferase activity
ISN37_13340	COG1063	alcohol dehydrogenase
ISN37_13350	COG3459	Glycosyltransferase 36 associated
ISN37_13410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN37_13420	COG0330	HflC and HflK could
ISN37_13425	COG0330	HflC and HflK could
ISN37_13430	COG0604	alcohol dehydrogenase
ISN37_13455	COG0678	peroxiredoxin activity
ISN37_13465	COG4953	penicillin-binding protein 1C
ISN37_13485	COG2373	Large extracellular alpha-helical protein
ISN37_13510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN37_13525	COG0372	Belongs to the citrate synthase family
ISN37_13530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN37_13545	COG0587	DNA-directed DNA polymerase activity
ISN37_13580	COG2161	toxin-antitoxin pair type II binding
ISN37_13585	COG4115	mRNA cleavage
ISN37_13605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN37_13610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN37_13615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN37_13625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN37_13630	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_13635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN37_13640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN37_13650	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN37_13675	COG0714	Associated with various cellular activities
ISN37_13695	COG0537	adenosine 5'-monophosphoramidase activity
ISN37_13735	COG0314	molybdopterin synthase activity
ISN37_13740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN37_13745	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN37_13755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN37_13760	COG1234	tRNA 3'-trailer cleavage
ISN37_13770	COG0859	PFAM glycosyl transferase family 9
ISN37_13790	COG0631	protein serine/threonine phosphatase activity
ISN37_13810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN37_13815	COG1388	LysM domain
ISN37_13815	COG3942	CHAP domain
ISN37_13850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN37_13860	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN37_13900	COG0473	3-isopropylmalate dehydrogenase activity
ISN37_13915	COG4783	chaperone-mediated protein folding
ISN37_13930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN37_13935	COG0248	Ppx GppA phosphatase
ISN37_13940	COG0438	transferase activity, transferring glycosyl groups
ISN37_13955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN37_13965	COG3291	Pkd domain containing protein
ISN37_13970	COG2833	Protein of unknown function (DUF455)
ISN37_13990	COG0285	dihydrofolate synthase activity
ISN37_13995	COG0588	phosphoglycerate mutase activity
ISN37_14015	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN37_14020	COG4208	sulfate ABC transporter
ISN37_14025	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN37_14030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN37_14035	COG0156	8-amino-7-oxononanoate synthase activity
ISN37_14050	COG2885	chlorophyll binding
ISN37_14060	COG2814	Major facilitator Superfamily
ISN37_14075	COG0667	Aldo Keto reductase
ISN37_14085	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN37_14085	COG1902	pentaerythritol trinitrate reductase activity
ISN37_14130	COG0625	glutathione transferase activity
ISN37_14145	COG0039	L-malate dehydrogenase activity
ISN37_14155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN37_14160	COG1217	gtp-binding protein TYPA
ISN37_14175	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN37_14185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN37_14190	COG0203	ribosomal protein L17
ISN37_14215	COG0201	protein transport
ISN37_14225	COG1841	ribosomal large subunit assembly
ISN37_14255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN37_14260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN37_14270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN37_14275	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN37_14300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN37_14305	COG0089	rRNA binding
ISN37_14310	COG0088	Forms part of the polypeptide exit tunnel
ISN37_14320	COG0051	transcription antitermination factor activity, RNA binding
ISN37_14325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN37_14330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN37_14345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN37_14355	COG0222	ribosome binding
ISN37_14370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN37_14375	COG0250	Participates in transcription elongation, termination and antitermination
ISN37_14380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN37_14390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN37_14410	COG0012	GTP binding
ISN37_14415	COG0193	aminoacyl-tRNA hydrolase activity
ISN37_14425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN37_14435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN37_14450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN37_14455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN37_14505	COG0488	(ABC) transporter
ISN37_14550	COG3634	alkyl hydroperoxide reductase activity
ISN37_14555	COG0583	DNA-binding transcription factor activity
ISN37_14565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN37_14570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN37_14600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN37_14605	COG0697	spore germination
ISN37_14645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN37_14650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN37_14660	COG2096	Adenosyltransferase
ISN37_14670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN37_14675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN37_14680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN37_14685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN37_14690	COG2967	ApaG domain
ISN37_14695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN37_14755	COG2188	Transcriptional regulator
ISN37_14765	COG1450	Type ii and iii secretion system protein
ISN37_14780	COG3166	PFAM Fimbrial assembly family protein
ISN37_14785	COG3156	type II secretion system protein K
ISN37_14790	COG4795	General secretion pathway protein
ISN37_14795	COG2165	general secretion pathway protein
ISN37_14800	COG4970	Tfp pilus assembly protein FimT
ISN37_14805	COG2165	general secretion pathway protein
ISN37_14810	COG1459	type II secretion system
ISN37_14815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN37_14820	COG1404	Belongs to the peptidase S8 family
ISN37_14825	COG5295	Hep Hag repeat protein
ISN37_14835	COG0840	transmembrane signaling receptor activity
ISN37_14840	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN37_14840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN37_14845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN37_14850	COG4974	Belongs to the 'phage' integrase family
ISN37_14875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN37_14880	COG2927	DNA polymerase III (CHI subunit)
ISN37_14915	COG1183	phosphatidylcholine synthase activity
ISN37_14925	COG0442	prolyl-tRNA aminoacylation
ISN37_14940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN37_14945	COG1127	ABC transporter
ISN37_14950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN37_14950	COG3218	ABC-type transport auxiliary lipoprotein component
ISN37_14980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN37_14985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN37_14990	COG0662	Cupin 2, conserved barrel domain protein
ISN37_14990	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN37_15015	COG2086	electron transfer activity
ISN37_15030	COG0546	phosphoglycolate phosphatase activity
ISN37_15030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN37_15035	COG0277	FAD linked oxidase domain protein
ISN37_15040	COG0300	oxidoreductase activity
ISN37_15065	COG0493	'glutamate synthase
ISN37_15110	COG0438	transferase activity, transferring glycosyl groups
ISN37_15110	COG1216	Glycosyl transferase, family 2
ISN37_15115	COG1216	Glycosyl transferase, family 2
ISN37_15115	COG0438	transferase activity, transferring glycosyl groups
ISN37_15120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN37_15135	COG0626	cystathionine gamma-synthase activity
ISN37_15165	COG0625	glutathione transferase activity
ISN37_15175	COG0513	Belongs to the DEAD box helicase family
ISN37_15180	COG0720	synthase
ISN37_15190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN37_15195	COG1956	GAF domain-containing protein
ISN37_15205	COG4206	TonB-dependent receptor
ISN37_15210	COG0546	phosphoglycolate phosphatase activity
ISN37_15215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISN37_15235	COG0339	signal peptide processing
ISN37_15250	COG2217	Heavy metal translocating P-type atpase
ISN37_15265	COG2132	Multicopper oxidase
ISN37_15280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN37_15290	COG1136	(ABC) transporter
ISN37_15295	COG1136	(ABC) transporter
ISN37_15295	COG0577	efflux transmembrane transporter activity
ISN37_15300	COG1136	(ABC) transporter
ISN37_15300	COG0577	efflux transmembrane transporter activity
ISN37_15305	COG1136	(ABC) transporter
ISN37_15305	COG0577	efflux transmembrane transporter activity
ISN37_15325	COG4191	Histidine kinase
ISN37_15335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN37_15350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN37_15365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN37_15375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN37_15385	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN37_15400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN37_15405	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN37_15440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN37_15445	COG0697	spore germination
ISN37_15450	COG1666	GTP binding
ISN37_15460	COG1187	pseudouridine synthase activity
ISN37_15485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN37_15485	COG2205	protein histidine kinase activity
ISN37_15510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN37_15585	COG0842	Transport permease protein
ISN37_15590	COG1131	(ABC) transporter
ISN37_15595	COG0025	NhaP-type Na H and K H
ISN37_15605	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN37_15610	COG1573	uracil-dna glycosylase
ISN37_15620	COG3384	dioxygenase
ISN37_15645	COG0667	Aldo Keto reductase
ISN37_15655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN37_15660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN37_15680	COG3706	GGDEF domain
ISN37_15685	COG2146	nitrite reductase [NAD(P)H] activity
ISN37_15690	COG5001	Diguanylate cyclase
ISN37_15720	COG4106	trans-aconitate 2-methyltransferase activity
ISN37_15730	COG2076	Multidrug Resistance protein
ISN37_15740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN37_15760	COG3279	Response regulator of the LytR AlgR family
ISN37_15765	COG3275	phosphorelay sensor kinase activity
ISN37_15790	COG0531	amino acid
ISN37_15800	COG5297	Belongs to the glycosyl hydrolase family 6
ISN37_15800	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN37_15815	COG0741	lytic transglycosylase activity
ISN37_15830	COG2207	Transcriptional regulator
ISN37_15840	COG0598	Magnesium transport protein CorA
ISN37_15845	COG1113	amino acid transport
ISN37_15850	COG0697	spore germination
ISN37_15875	COG5520	Belongs to the glycosyl hydrolase 30 family
ISN37_15980	COG0840	transmembrane signaling receptor activity
ISN37_15995	COG2353	YceI-like domain
ISN37_16025	COG0584	glycerophosphoryl diester phosphodiesterase
ISN37_16040	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN37_16060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN37_16080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ISN37_16090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ISN37_16095	COG0459	protein refolding
ISN37_16110	COG1324	tolerance protein
ISN37_16120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN37_16130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN37_16135	COG0511	ligase activity, forming carbon-carbon bonds
ISN37_16140	COG0439	Biotin carboxylase
ISN37_16155	COG2264	protein methyltransferase activity
ISN37_16175	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN37_16180	COG4589	Belongs to the CDS family
ISN37_16200	COG2267	carboxylic ester hydrolase activity
ISN37_16205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN37_16210	COG0138	bifunctional purine biosynthesis protein purh
ISN37_16215	COG0151	Belongs to the GarS family
ISN37_16220	COG1289	transmembrane transporter activity
ISN37_16225	COG2814	Major facilitator Superfamily
ISN37_16265	COG2816	NAD+ diphosphatase activity
ISN37_16305	COG2906	2 iron, 2 sulfur cluster binding
ISN37_16335	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN37_16350	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN37_16355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN37_16360	COG0730	response to heat
ISN37_16375	COG0134	indole-3-glycerol-phosphate synthase activity
ISN37_16380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN37_16400	COG1597	lipid kinase activity
ISN37_16415	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN37_16430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN37_16435	COG2111	Na H antiporter
ISN37_16435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN37_16440	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN37_16445	COG0651	ATP synthesis coupled electron transport
ISN37_16450	COG1863	multisubunit Na H antiporter MnhE subunit
ISN37_16455	COG2212	antiporter activity
ISN37_16460	COG1320	monovalent cation:proton antiporter activity
ISN37_16465	COG0530	calcium, potassium:sodium antiporter activity
ISN37_16480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN37_16500	COG3104	oligopeptide transport
ISN37_16535	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN37_16565	COG0513	Belongs to the DEAD box helicase family
ISN37_16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN37_16590	COG2354	Protein conserved in bacteria
ISN37_16615	COG1196	nuclear chromosome segregation
ISN37_16615	COG3264	Mechanosensitive ion channel
ISN37_16620	COG0604	alcohol dehydrogenase
ISN37_16620	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_16620	COG3321	synthase
ISN37_16640	COG1595	DNA-templated transcription, initiation
ISN37_16655	COG1802	Transcriptional regulator
ISN37_16690	COG3052	prosthetic group binding
ISN37_16700	COG1414	Transcriptional regulator
ISN37_16705	COG0738	Major facilitator superfamily
ISN37_16710	COG3254	rhamnose metabolic process
ISN37_16715	COG4948	Mandelate Racemase Muconate Lactonizing
ISN37_16720	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN37_16725	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_16760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN37_16775	COG4807	Protein conserved in bacteria
ISN37_16800	COG4773	Receptor
ISN37_16820	COG1506	peptidase
ISN37_16820	COG0823	Involved in the tonB-independent uptake of proteins
ISN37_16880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN37_16900	COG0628	permease
ISN37_16905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN37_16910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN37_16915	COG0753	catalase activity
ISN37_16940	COG1136	(ABC) transporter
ISN37_16945	COG0577	efflux transmembrane transporter activity
ISN37_16965	COG0697	spore germination
ISN37_16980	COG0180	Tryptophanyl-tRNA synthetase
ISN37_17015	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN37_17020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN37_17020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN37_17030	COG3228	Belongs to the MtfA family
ISN37_17060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN37_17085	COG2084	Dehydrogenase
ISN37_17090	COG1902	pentaerythritol trinitrate reductase activity
ISN37_17115	COG1404	Belongs to the peptidase S8 family
ISN37_17120	COG2814	Major facilitator Superfamily
ISN37_17125	COG0583	DNA-binding transcription factor activity
ISN37_17145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN37_17150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN37_17160	COG1764	response to oxidative stress
ISN37_17165	COG1846	Transcriptional regulator
ISN37_17170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN37_17180	COG0697	spore germination
ISN37_17185	COG0523	cobalamin synthesis protein
ISN37_17195	COG1742	UPF0060 membrane protein
ISN37_17210	COG1960	acyl-CoA dehydrogenase activity
ISN37_17215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN37_17245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN37_17250	COG3387	PFAM Glycoside hydrolase 15-related
ISN37_17255	COG0745	RESPONSE REGULATOR receiver
ISN37_17270	COG1404	Belongs to the peptidase S8 family
ISN37_17280	COG3100	YcgL domain-containing protein
ISN37_17285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN37_17295	COG0463	Glycosyl transferase, family 2
ISN37_17330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN37_17345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN37_17370	COG1294	oxidase, subunit
ISN37_17375	COG1271	oxidase subunit
ISN37_17395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN37_17400	COG0408	coproporphyrinogen oxidase activity
ISN37_17410	COG2323	membrane
ISN37_17415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN37_17415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN37_17430	COG0589	response to stress
ISN37_17450	COG0210	DNA helicase
ISN37_17500	COG0463	Glycosyl transferase, family 2
ISN37_17510	COG1475	DNA binding
ISN37_17515	COG1192	Involved in chromosome partitioning
ISN37_17520	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN37_17535	COG2091	lysine biosynthetic process via aminoadipic acid
ISN37_17560	COG0477	Major facilitator Superfamily
ISN37_17580	COG1971	Probably functions as a manganese efflux pump
ISN37_17585	COG2205	protein histidine kinase activity
ISN37_17595	COG3459	Glycosyltransferase 36 associated
ISN37_17600	COG2211	Major facilitator Superfamily
ISN37_17605	COG3265	gluconokinase activity
ISN37_17620	COG2911	Protein conserved in bacteria
ISN37_17625	COG0729	surface antigen
ISN37_17650	COG3132	Protein of unknown function, DUF480
ISN37_17695	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN37_17720	COG2937	Belongs to the GPAT DAPAT family
ISN37_17745	COG2211	Major facilitator Superfamily
ISN37_17760	COG3693	PFAM glycoside hydrolase, family 10
ISN37_17780	COG3386	PFAM SMP-30 Gluconolaconase
ISN37_17795	COG0246	Mannitol dehydrogenase
ISN37_17800	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN37_17810	COG4948	Mandelate Racemase Muconate Lactonizing
ISN37_17820	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN37_17830	COG2115	Belongs to the xylose isomerase family
ISN37_17835	COG0037	tRNA processing
ISN37_17855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN37_17865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN37_17875	COG0805	protein transport
ISN37_17885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN37_17885	COG0519	Catalyzes the synthesis of GMP from XMP
ISN37_17890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN37_17910	COG0210	DNA helicase
ISN37_17915	COG1435	thymidine kinase activity
ISN37_17925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN37_17950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN37_17965	COG1119	ATPase activity
ISN37_17980	COG0706	membrane insertase activity
ISN37_17985	COG0594	ribonuclease P activity
ISN37_18005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN37_18010	COG0187	DNA topoisomerase II activity
ISN37_18015	COG1266	CAAX protease self-immunity
ISN37_18020	COG0501	Belongs to the peptidase M48B family
ISN37_18060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN37_18075	COG1280	lysine exporter protein (LysE YggA)
ISN37_18090	COG4772	TonB-dependent receptor
ISN37_18100	COG3284	Transcriptional regulator
ISN37_18105	COG1012	belongs to the aldehyde dehydrogenase family
ISN37_18140	COG1304	FMN binding
ISN37_18175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN37_18250	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN37_18270	COG4771	TonB-dependent receptor
ISN37_18315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN37_18330	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN37_18335	COG1609	Transcriptional regulator
ISN37_18345	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_18360	COG3186	Phenylalanine-4-hydroxylase
ISN37_18365	COG1522	sequence-specific DNA binding
ISN37_18385	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN37_18405	COG0671	phosphoesterase, PA-phosphatase related
ISN37_18420	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN37_18455	COG1929	Belongs to the glycerate kinase type-1 family
ISN37_18465	COG0531	amino acid
ISN37_18470	COG4566	intracellular signal transduction
ISN37_18475	COG4191	Histidine kinase
ISN37_18495	COG1322	Protein conserved in bacteria
ISN37_18500	COG0386	Belongs to the glutathione peroxidase family
ISN37_18505	COG2853	Lipoprotein
ISN37_18520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN37_18525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN37_18530	COG1127	ABC transporter
ISN37_18535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN37_18540	COG1074	ATP-dependent DNA helicase activity
ISN37_18545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN37_18565	COG0537	adenosine 5'-monophosphoramidase activity
ISN37_18630	COG0477	Major facilitator Superfamily
ISN37_18635	COG0302	gtp cyclohydrolase
ISN37_18660	COG0730	response to heat
ISN37_18675	COG2951	lytic endotransglycosylase activity
ISN37_18735	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN37_18740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN37_18745	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN37_18750	COG0493	'glutamate synthase
ISN37_18755	COG0067	glutamate synthase
ISN37_18755	COG0070	glutamate synthase
ISN37_18755	COG0069	glutamate synthase activity
ISN37_18800	COG1111	helicase
ISN37_18800	COG1205	dead DEAH box helicase
ISN37_18835	COG2271	Major facilitator Superfamily
ISN37_18885	COG1192	Involved in chromosome partitioning
ISN37_18890	COG2062	phosphohistidine phosphatase, SixA
ISN37_18900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN37_18905	COG2050	protein possibly involved in aromatic compounds catabolism
ISN37_18915	COG2267	carboxylic ester hydrolase activity
ISN37_18930	COG1881	PFAM PEBP family protein
ISN37_18935	COG1968	undecaprenyl-diphosphatase activity
ISN37_18940	COG0174	glutamine synthetase
ISN37_18945	COG0347	Belongs to the P(II) protein family
ISN37_18950	COG0004	ammonium transporteR
ISN37_18955	COG3852	Histidine kinase
ISN37_18960	COG2204	response regulator
ISN37_18965	COG2032	superoxide dismutase activity
ISN37_18970	COG2032	superoxide dismutase activity
ISN37_18980	COG0183	Belongs to the thiolase family
ISN37_19020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN37_19025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN37_19035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN37_19045	COG0612	Peptidase, M16
ISN37_19055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN37_19065	COG0596	Alpha beta hydrolase
ISN37_19075	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN37_19080	COG0318	PFAM AMP-dependent synthetase and ligase
ISN37_19095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN37_19105	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN37_19120	COG4232	protein-disulfide reductase activity
ISN37_19125	COG0564	pseudouridine synthase activity
ISN37_19145	COG0339	signal peptide processing
ISN37_19165	COG0583	DNA-binding transcription factor activity
ISN37_19170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN37_19175	COG2224	Isocitrate lyase
ISN37_19210	COG0659	secondary active sulfate transmembrane transporter activity
ISN37_19245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN37_19250	COG2130	NADP-dependent
ISN37_19265	COG1187	pseudouridine synthase activity
ISN37_19290	COG0084	hydrolase, TatD family'
ISN37_19305	COG0842	Transport permease protein
ISN37_19310	COG1131	(ABC) transporter
ISN37_19315	COG0633	Ferredoxin
ISN37_19315	COG0543	2 iron, 2 sulfur cluster binding
ISN37_19325	COG1476	TRANSCRIPTIONal
ISN37_19335	COG4555	ABC transporter
ISN37_19355	COG0625	glutathione transferase activity
ISN37_19430	COG1199	ATP-dependent helicase activity
ISN37_19490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN37_19515	COG0628	permease
ISN37_19525	COG2133	pyrroloquinoline quinone binding
ISN37_19575	COG0754	glutathionylspermidine amidase activity
ISN37_19585	COG0714	Associated with various cellular activities
ISN37_19630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN37_19645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN37_19650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN37_19675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN37_19695	COG1028	Short-chain dehydrogenase reductase Sdr
ISN37_19710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN37_19720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN37_19755	COG0606	chelatase, subunit chli
ISN37_19760	COG2960	long-chain fatty acid transporting porin activity
ISN37_19790	COG1166	arginine decarboxylase activity
ISN37_19805	COG2755	lipolytic protein G-D-S-L family
ISN37_19805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN37_19810	COG0583	DNA-binding transcription factor activity
ISN37_19830	COG4221	oxidoreductase activity
ISN37_19850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN37_19870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN37_19880	COG2814	Major facilitator Superfamily
ISN37_19890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ISN37_19895	COG0739	heme binding
ISN37_19900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)