locus-tag	class	description
ISN35_00015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN35_00020	COG1295	ribonuclease BN
ISN35_00040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISN35_00050	COG1404	Belongs to the peptidase S8 family
ISN35_00055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN35_00095	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISN35_00115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN35_00115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN35_00175	COG4651	solute:proton antiporter activity
ISN35_00175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN35_00185	COG4772	TonB-dependent receptor
ISN35_00195	COG4264	IucA IucC family
ISN35_00200	COG2814	Major facilitator Superfamily
ISN35_00205	COG4264	IucA IucC family
ISN35_00210	COG0019	diaminopimelate decarboxylase activity
ISN35_00235	COG0542	response to heat
ISN35_00285	COG3387	PFAM Glycoside hydrolase 15-related
ISN35_00300	COG4993	Dehydrogenase
ISN35_00320	COG0564	pseudouridine synthase activity
ISN35_00325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN35_00335	COG1125	glycine betaine transport
ISN35_00340	COG1174	glycine betaine transport
ISN35_00360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN35_00370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN35_00370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN35_00440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN35_00455	COG0745	RESPONSE REGULATOR receiver
ISN35_00465	COG0189	ligase activity
ISN35_00475	COG3511	phospholipase C
ISN35_00495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN35_00510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN35_00520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN35_00525	COG0174	glutamine synthetase
ISN35_00550	COG0084	hydrolase, TatD family'
ISN35_00585	COG2003	Belongs to the UPF0758 family
ISN35_00665	COG2022	thiamine diphosphate biosynthetic process
ISN35_00675	COG3273	potassium ion transport
ISN35_00675	COG0471	metal ion transport
ISN35_00690	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN35_00705	COG1609	Transcriptional regulator
ISN35_00725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN35_00740	COG1115	amino acid carrier protein
ISN35_00760	COG0840	transmembrane signaling receptor activity
ISN35_00765	COG2895	sulfate adenylyltransferase (ATP) activity
ISN35_00765	COG0529	Catalyzes the synthesis of activated sulfate
ISN35_00775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN35_00780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN35_00785	COG0175	sulfate reduction
ISN35_00815	COG1393	Belongs to the ArsC family
ISN35_00820	COG2205	protein histidine kinase activity
ISN35_00820	COG0784	Response regulator, receiver
ISN35_00820	COG2198	Histidine kinase
ISN35_00835	COG1648	precorrin-2 dehydrogenase activity
ISN35_00835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN35_00850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN35_00890	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN35_00895	COG3588	fructose-bisphosphate aldolase
ISN35_00900	COG0469	pyruvate kinase activity
ISN35_00945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN35_00950	COG3047	cAMP biosynthetic process
ISN35_00970	COG0640	Transcriptional regulator
ISN35_00980	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN35_00985	COG4149	molybdate abc transporter
ISN35_00990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN35_01015	COG1376	ErfK ybiS ycfS ynhG family protein
ISN35_01020	COG0739	heme binding
ISN35_01045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN35_01050	COG1301	dicarboxylic acid transport
ISN35_01080	COG0714	Associated with various cellular activities
ISN35_01110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN35_01125	COG0006	proline dipeptidase activity
ISN35_01130	COG3079	Belongs to the UPF0149 family
ISN35_01155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN35_01165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN35_01185	COG1773	rubredoxin
ISN35_01200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN35_01215	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
ISN35_01235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN35_01245	COG1940	carbohydrate kinase activity
ISN35_01260	COG0671	phosphoesterase, PA-phosphatase related
ISN35_01270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN35_01290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN35_01300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN35_01320	COG0840	transmembrane signaling receptor activity
ISN35_01325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN35_01345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN35_01355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN35_01365	COG0066	3-isopropylmalate dehydratase activity
ISN35_01370	COG0473	3-isopropylmalate dehydrogenase activity
ISN35_01375	COG3706	GGDEF domain
ISN35_01385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN35_01390	COG1538	Outer membrane efflux protein
ISN35_01395	COG1519	Transferase
ISN35_01400	COG1560	Kdo2-lipid A biosynthetic process
ISN35_01470	COG0280	phosphate acetyltransferase
ISN35_01470	COG0281	malic enzyme
ISN35_01475	COG1301	dicarboxylic acid transport
ISN35_01485	COG4191	Histidine kinase
ISN35_01505	COG0642	Histidine kinase
ISN35_01520	COG2851	Citrate transporter
ISN35_01525	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_01535	COG2211	Major facilitator Superfamily
ISN35_01560	COG1162	GTPase activity
ISN35_01590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN35_01610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN35_01615	COG0804	urea catabolic process
ISN35_01655	COG3791	Glutathione-dependent formaldehyde-activating
ISN35_01660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN35_01675	COG2205	protein histidine kinase activity
ISN35_01745	COG0617	tRNA 3'-terminal CCA addition
ISN35_01750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN35_01755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN35_01760	COG1609	Transcriptional regulator
ISN35_01765	COG0738	Major facilitator superfamily
ISN35_01770	COG2188	Transcriptional regulator
ISN35_01785	COG3250	beta-galactosidase activity
ISN35_01815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN35_01825	COG4191	Histidine kinase
ISN35_01830	COG0784	Response regulator, receiver
ISN35_01835	COG2205	protein histidine kinase activity
ISN35_01835	COG2202	Pas domain
ISN35_01845	COG2823	Periplasmic or secreted lipoprotein
ISN35_01850	COG0673	inositol 2-dehydrogenase activity
ISN35_01855	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN35_01865	COG1090	epimerase
ISN35_01880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN35_01920	COG2226	methyltransferase
ISN35_01945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN35_01955	COG0494	nUDIX hydrolase
ISN35_01970	COG0739	heme binding
ISN35_01980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN35_01985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN35_01995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN35_02000	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN35_02010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISN35_02025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN35_02040	COG3116	cell division
ISN35_02045	COG0275	rRNA processing
ISN35_02050	COG2001	Belongs to the MraZ family
ISN35_02085	COG0792	nuclease activity
ISN35_02095	COG0277	FAD linked oxidase domain protein
ISN35_02100	COG0745	RESPONSE REGULATOR receiver
ISN35_02105	COG2205	protein histidine kinase activity
ISN35_02115	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN35_02120	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN35_02145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN35_02150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN35_02155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN35_02170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN35_02170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN35_02180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN35_02215	COG0477	Major facilitator Superfamily
ISN35_02220	COG0488	(ABC) transporter
ISN35_02225	COG0242	peptide deformylase activity
ISN35_02255	COG1215	transferase activity, transferring glycosyl groups
ISN35_02265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN35_02320	COG2188	Transcriptional regulator
ISN35_02330	COG1450	Type ii and iii secretion system protein
ISN35_02345	COG3166	PFAM Fimbrial assembly family protein
ISN35_02350	COG3156	type II secretion system protein K
ISN35_02355	COG4795	General secretion pathway protein
ISN35_02360	COG2165	general secretion pathway protein
ISN35_02365	COG4970	Tfp pilus assembly protein FimT
ISN35_02370	COG2165	general secretion pathway protein
ISN35_02375	COG1459	type II secretion system
ISN35_02380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN35_02385	COG1404	Belongs to the peptidase S8 family
ISN35_02390	COG5295	Hep Hag repeat protein
ISN35_02400	COG0840	transmembrane signaling receptor activity
ISN35_02405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN35_02405	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN35_02410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN35_02415	COG4974	Belongs to the 'phage' integrase family
ISN35_02440	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN35_02445	COG2927	DNA polymerase III (CHI subunit)
ISN35_02480	COG1183	phosphatidylcholine synthase activity
ISN35_02490	COG0442	prolyl-tRNA aminoacylation
ISN35_02505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN35_02510	COG1127	ABC transporter
ISN35_02515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN35_02515	COG3218	ABC-type transport auxiliary lipoprotein component
ISN35_02545	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN35_02550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN35_02555	COG0662	Cupin 2, conserved barrel domain protein
ISN35_02555	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN35_02580	COG2086	electron transfer activity
ISN35_02595	COG0546	phosphoglycolate phosphatase activity
ISN35_02595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN35_02600	COG0277	FAD linked oxidase domain protein
ISN35_02605	COG0300	oxidoreductase activity
ISN35_02630	COG0493	'glutamate synthase
ISN35_02670	COG0438	transferase activity, transferring glycosyl groups
ISN35_02670	COG1216	Glycosyl transferase, family 2
ISN35_02675	COG0438	transferase activity, transferring glycosyl groups
ISN35_02675	COG1216	Glycosyl transferase, family 2
ISN35_02680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN35_02695	COG0626	cystathionine gamma-synthase activity
ISN35_02730	COG0625	glutathione transferase activity
ISN35_02740	COG0513	Belongs to the DEAD box helicase family
ISN35_02745	COG0720	synthase
ISN35_02755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN35_02760	COG1956	GAF domain-containing protein
ISN35_02770	COG4206	TonB-dependent receptor
ISN35_02775	COG0546	phosphoglycolate phosphatase activity
ISN35_02780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISN35_02800	COG0339	signal peptide processing
ISN35_02815	COG2217	Heavy metal translocating P-type atpase
ISN35_02830	COG2132	Multicopper oxidase
ISN35_02845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN35_02855	COG1136	(ABC) transporter
ISN35_02860	COG1136	(ABC) transporter
ISN35_02860	COG0577	efflux transmembrane transporter activity
ISN35_02865	COG0577	efflux transmembrane transporter activity
ISN35_02865	COG1136	(ABC) transporter
ISN35_02870	COG1136	(ABC) transporter
ISN35_02870	COG0577	efflux transmembrane transporter activity
ISN35_02890	COG4191	Histidine kinase
ISN35_02900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN35_02915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN35_02930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN35_02940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN35_02950	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN35_02965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN35_02970	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN35_03005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN35_03010	COG0697	spore germination
ISN35_03015	COG1666	GTP binding
ISN35_03025	COG1187	pseudouridine synthase activity
ISN35_03050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN35_03050	COG2205	protein histidine kinase activity
ISN35_03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN35_03150	COG0842	Transport permease protein
ISN35_03155	COG1131	(ABC) transporter
ISN35_03160	COG0025	NhaP-type Na H and K H
ISN35_03170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN35_03175	COG1573	uracil-dna glycosylase
ISN35_03185	COG3384	dioxygenase
ISN35_03210	COG0667	Aldo Keto reductase
ISN35_03220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN35_03225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN35_03245	COG3706	GGDEF domain
ISN35_03250	COG2146	nitrite reductase [NAD(P)H] activity
ISN35_03255	COG5001	Diguanylate cyclase
ISN35_03285	COG4106	trans-aconitate 2-methyltransferase activity
ISN35_03295	COG2076	Multidrug Resistance protein
ISN35_03305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN35_03325	COG3279	Response regulator of the LytR AlgR family
ISN35_03330	COG3275	phosphorelay sensor kinase activity
ISN35_03335	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ISN35_03355	COG0531	amino acid
ISN35_03365	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN35_03365	COG5297	Belongs to the glycosyl hydrolase family 6
ISN35_03380	COG0741	lytic transglycosylase activity
ISN35_03400	COG2207	Transcriptional regulator
ISN35_03410	COG0598	Magnesium transport protein CorA
ISN35_03415	COG1113	amino acid transport
ISN35_03420	COG0697	spore germination
ISN35_03445	COG5520	Belongs to the glycosyl hydrolase 30 family
ISN35_03530	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN35_03550	COG0840	transmembrane signaling receptor activity
ISN35_03565	COG2353	YceI-like domain
ISN35_03595	COG0584	glycerophosphoryl diester phosphodiesterase
ISN35_03610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN35_03630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN35_03635	COG0459	protein refolding
ISN35_03650	COG1324	tolerance protein
ISN35_03660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN35_03670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN35_03675	COG0511	ligase activity, forming carbon-carbon bonds
ISN35_03680	COG0439	Biotin carboxylase
ISN35_03695	COG2264	protein methyltransferase activity
ISN35_03715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN35_03725	COG4589	Belongs to the CDS family
ISN35_03745	COG2267	carboxylic ester hydrolase activity
ISN35_03750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN35_03755	COG0138	bifunctional purine biosynthesis protein purh
ISN35_03760	COG0151	Belongs to the GarS family
ISN35_03765	COG1289	transmembrane transporter activity
ISN35_03770	COG2814	Major facilitator Superfamily
ISN35_03810	COG2816	NAD+ diphosphatase activity
ISN35_03850	COG2906	2 iron, 2 sulfur cluster binding
ISN35_03880	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN35_03895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN35_03900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN35_03905	COG0730	response to heat
ISN35_03920	COG0134	indole-3-glycerol-phosphate synthase activity
ISN35_03925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN35_03945	COG1597	lipid kinase activity
ISN35_03960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN35_03975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN35_03980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN35_03980	COG2111	Na H antiporter
ISN35_03985	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN35_03990	COG0651	ATP synthesis coupled electron transport
ISN35_03995	COG1863	multisubunit Na H antiporter MnhE subunit
ISN35_04000	COG2212	antiporter activity
ISN35_04005	COG1320	monovalent cation:proton antiporter activity
ISN35_04010	COG0530	calcium, potassium:sodium antiporter activity
ISN35_04030	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN35_04050	COG3104	oligopeptide transport
ISN35_04055	COG3483	tryptophan 2,3-dioxygenase activity
ISN35_04070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISN35_04085	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN35_04115	COG0513	Belongs to the DEAD box helicase family
ISN35_04130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN35_04140	COG2354	Protein conserved in bacteria
ISN35_04165	COG1196	nuclear chromosome segregation
ISN35_04165	COG3264	Mechanosensitive ion channel
ISN35_04170	COG0604	alcohol dehydrogenase
ISN35_04170	COG3321	synthase
ISN35_04170	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_04190	COG1595	DNA-templated transcription, initiation
ISN35_04205	COG1802	Transcriptional regulator
ISN35_04240	COG3052	prosthetic group binding
ISN35_04250	COG1414	Transcriptional regulator
ISN35_04255	COG0738	Major facilitator superfamily
ISN35_04260	COG3254	rhamnose metabolic process
ISN35_04270	COG4948	Mandelate Racemase Muconate Lactonizing
ISN35_04275	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN35_04280	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_04315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN35_04330	COG4807	Protein conserved in bacteria
ISN35_04350	COG4773	Receptor
ISN35_04370	COG0823	Involved in the tonB-independent uptake of proteins
ISN35_04370	COG1506	peptidase
ISN35_04420	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ISN35_04440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN35_04460	COG0628	permease
ISN35_04465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN35_04470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN35_04475	COG0753	catalase activity
ISN35_04505	COG0577	efflux transmembrane transporter activity
ISN35_04525	COG0697	spore germination
ISN35_04540	COG0180	Tryptophanyl-tRNA synthetase
ISN35_04575	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN35_04580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN35_04580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN35_04590	COG3228	Belongs to the MtfA family
ISN35_04625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN35_04650	COG2084	Dehydrogenase
ISN35_04655	COG1902	pentaerythritol trinitrate reductase activity
ISN35_04680	COG1404	Belongs to the peptidase S8 family
ISN35_04685	COG2814	Major facilitator Superfamily
ISN35_04690	COG0583	DNA-binding transcription factor activity
ISN35_04710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN35_04715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN35_04730	COG1764	response to oxidative stress
ISN35_04735	COG1846	Transcriptional regulator
ISN35_04740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN35_04750	COG0697	spore germination
ISN35_04760	COG0523	cobalamin synthesis protein
ISN35_04770	COG1742	UPF0060 membrane protein
ISN35_04780	COG3245	cytochrome
ISN35_04790	COG1960	acyl-CoA dehydrogenase activity
ISN35_04795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN35_04825	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN35_04830	COG3387	PFAM Glycoside hydrolase 15-related
ISN35_04835	COG0745	RESPONSE REGULATOR receiver
ISN35_04850	COG1404	Belongs to the peptidase S8 family
ISN35_04860	COG3100	YcgL domain-containing protein
ISN35_04865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN35_04875	COG0463	Glycosyl transferase, family 2
ISN35_04910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN35_04925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN35_04950	COG1294	oxidase, subunit
ISN35_04955	COG1271	oxidase subunit
ISN35_04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN35_04975	COG0408	coproporphyrinogen oxidase activity
ISN35_04985	COG2323	membrane
ISN35_04990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN35_04990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN35_05005	COG0589	response to stress
ISN35_05025	COG0210	DNA helicase
ISN35_05075	COG0463	Glycosyl transferase, family 2
ISN35_05085	COG1475	DNA binding
ISN35_05090	COG1192	Involved in chromosome partitioning
ISN35_05095	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN35_05110	COG2091	lysine biosynthetic process via aminoadipic acid
ISN35_05135	COG0477	Major facilitator Superfamily
ISN35_05155	COG1971	Probably functions as a manganese efflux pump
ISN35_05160	COG2205	protein histidine kinase activity
ISN35_05170	COG3459	Glycosyltransferase 36 associated
ISN35_05175	COG2211	Major facilitator Superfamily
ISN35_05180	COG3265	gluconokinase activity
ISN35_05195	COG2911	Protein conserved in bacteria
ISN35_05200	COG0729	surface antigen
ISN35_05220	COG3132	Protein of unknown function, DUF480
ISN35_05275	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN35_05290	COG1609	Transcriptional regulator
ISN35_05300	COG2937	Belongs to the GPAT DAPAT family
ISN35_05325	COG2211	Major facilitator Superfamily
ISN35_05340	COG3693	PFAM glycoside hydrolase, family 10
ISN35_05360	COG3386	PFAM SMP-30 Gluconolaconase
ISN35_05375	COG0246	Mannitol dehydrogenase
ISN35_05380	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN35_05390	COG4948	Mandelate Racemase Muconate Lactonizing
ISN35_05400	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN35_05410	COG2115	Belongs to the xylose isomerase family
ISN35_05415	COG0037	tRNA processing
ISN35_05435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN35_05445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN35_05455	COG0805	protein transport
ISN35_05465	COG0519	Catalyzes the synthesis of GMP from XMP
ISN35_05465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN35_05470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN35_05490	COG0210	DNA helicase
ISN35_05495	COG1435	thymidine kinase activity
ISN35_05505	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN35_05530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN35_05545	COG1119	ATPase activity
ISN35_05560	COG0706	membrane insertase activity
ISN35_05565	COG0594	ribonuclease P activity
ISN35_05585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN35_05590	COG0187	DNA topoisomerase II activity
ISN35_05595	COG1266	CAAX protease self-immunity
ISN35_05600	COG0501	Belongs to the peptidase M48B family
ISN35_05640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN35_05655	COG1280	lysine exporter protein (LysE YggA)
ISN35_05670	COG4772	TonB-dependent receptor
ISN35_05680	COG3284	Transcriptional regulator
ISN35_05685	COG1012	belongs to the aldehyde dehydrogenase family
ISN35_05720	COG1304	FMN binding
ISN35_05755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN35_05830	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN35_05850	COG4771	TonB-dependent receptor
ISN35_05895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN35_05910	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN35_05915	COG1609	Transcriptional regulator
ISN35_05925	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_05940	COG3186	Phenylalanine-4-hydroxylase
ISN35_05945	COG1522	sequence-specific DNA binding
ISN35_05960	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN35_05980	COG0671	phosphoesterase, PA-phosphatase related
ISN35_05995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN35_06030	COG1929	Belongs to the glycerate kinase type-1 family
ISN35_06040	COG0531	amino acid
ISN35_06045	COG4566	intracellular signal transduction
ISN35_06050	COG4191	Histidine kinase
ISN35_06070	COG1322	Protein conserved in bacteria
ISN35_06075	COG0386	Belongs to the glutathione peroxidase family
ISN35_06080	COG2853	Lipoprotein
ISN35_06095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN35_06100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN35_06105	COG1127	ABC transporter
ISN35_06110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN35_06115	COG1074	ATP-dependent DNA helicase activity
ISN35_06120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN35_06140	COG0537	adenosine 5'-monophosphoramidase activity
ISN35_06215	COG0477	Major facilitator Superfamily
ISN35_06220	COG0302	gtp cyclohydrolase
ISN35_06245	COG0730	response to heat
ISN35_06260	COG2951	lytic endotransglycosylase activity
ISN35_06320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN35_06325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN35_06330	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN35_06335	COG0493	'glutamate synthase
ISN35_06340	COG0067	glutamate synthase
ISN35_06340	COG0069	glutamate synthase activity
ISN35_06340	COG0070	glutamate synthase
ISN35_06385	COG1111	helicase
ISN35_06385	COG1205	dead DEAH box helicase
ISN35_06420	COG2271	Major facilitator Superfamily
ISN35_06465	COG1192	Involved in chromosome partitioning
ISN35_06470	COG2062	phosphohistidine phosphatase, SixA
ISN35_06480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN35_06485	COG2050	protein possibly involved in aromatic compounds catabolism
ISN35_06495	COG2267	carboxylic ester hydrolase activity
ISN35_06510	COG1881	PFAM PEBP family protein
ISN35_06515	COG1968	undecaprenyl-diphosphatase activity
ISN35_06520	COG0174	glutamine synthetase
ISN35_06525	COG0347	Belongs to the P(II) protein family
ISN35_06530	COG0004	ammonium transporteR
ISN35_06535	COG3852	Histidine kinase
ISN35_06540	COG2204	response regulator
ISN35_06545	COG2032	superoxide dismutase activity
ISN35_06550	COG2032	superoxide dismutase activity
ISN35_06560	COG0183	Belongs to the thiolase family
ISN35_06600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN35_06605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN35_06615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN35_06625	COG0612	Peptidase, M16
ISN35_06635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN35_06645	COG0596	Alpha beta hydrolase
ISN35_06655	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN35_06660	COG0318	PFAM AMP-dependent synthetase and ligase
ISN35_06675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN35_06685	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN35_06700	COG4232	protein-disulfide reductase activity
ISN35_06705	COG0564	pseudouridine synthase activity
ISN35_06725	COG0339	signal peptide processing
ISN35_06745	COG0583	DNA-binding transcription factor activity
ISN35_06750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN35_06755	COG2224	Isocitrate lyase
ISN35_06790	COG0659	secondary active sulfate transmembrane transporter activity
ISN35_06825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN35_06830	COG2130	NADP-dependent
ISN35_06845	COG1187	pseudouridine synthase activity
ISN35_06865	COG0084	hydrolase, TatD family'
ISN35_06880	COG0842	Transport permease protein
ISN35_06885	COG1131	(ABC) transporter
ISN35_06890	COG0543	2 iron, 2 sulfur cluster binding
ISN35_06890	COG0633	Ferredoxin
ISN35_06900	COG1476	TRANSCRIPTIONal
ISN35_06910	COG4555	ABC transporter
ISN35_06930	COG0625	glutathione transferase activity
ISN35_07005	COG1199	ATP-dependent helicase activity
ISN35_07065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN35_07090	COG0628	permease
ISN35_07100	COG2133	pyrroloquinoline quinone binding
ISN35_07155	COG0754	glutathionylspermidine amidase activity
ISN35_07165	COG0714	Associated with various cellular activities
ISN35_07210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN35_07225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN35_07230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN35_07255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN35_07275	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_07290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN35_07300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN35_07330	COG0606	chelatase, subunit chli
ISN35_07335	COG2960	long-chain fatty acid transporting porin activity
ISN35_07365	COG1166	arginine decarboxylase activity
ISN35_07370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISN35_07380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN35_07380	COG2755	lipolytic protein G-D-S-L family
ISN35_07385	COG0583	DNA-binding transcription factor activity
ISN35_07405	COG4221	oxidoreductase activity
ISN35_07425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN35_07445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN35_07455	COG2814	Major facilitator Superfamily
ISN35_07470	COG0739	heme binding
ISN35_07475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN35_07505	COG1064	alcohol dehydrogenase
ISN35_07510	COG2234	aminopeptidase activity
ISN35_07520	COG4942	peptidase
ISN35_07525	COG0793	Belongs to the peptidase S41A family
ISN35_07555	COG0531	amino acid
ISN35_07580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN35_07580	COG1565	acr, cog1565
ISN35_07585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN35_07590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN35_07625	COG0109	protoheme IX farnesyltransferase activity
ISN35_07640	COG0358	DNA primase activity
ISN35_07645	COG1295	ribonuclease BN
ISN35_07665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN35_07670	COG2308	Evidence 4 Homologs of previously reported genes of
ISN35_07685	COG2133	pyrroloquinoline quinone binding
ISN35_07705	COG0531	amino acid
ISN35_07715	COG4948	Mandelate Racemase Muconate Lactonizing
ISN35_07725	COG4771	TonB-dependent receptor
ISN35_07730	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISN35_07780	COG5383	Protein conserved in bacteria
ISN35_07795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN35_07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN35_07815	COG1652	LysM domain
ISN35_07825	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN35_07830	COG1518	maintenance of DNA repeat elements
ISN35_07875	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN35_07885	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN35_07890	COG3118	belongs to the thioredoxin family
ISN35_07900	COG2884	Cell division ATP-binding protein ftsE
ISN35_07905	COG2177	Part of the ABC transporter FtsEX involved in
ISN35_07910	COG2201	protein-glutamate methylesterase activity
ISN35_07915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN35_07920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN35_07925	COG2860	membrane
ISN35_07930	COG1252	NADH dehydrogenase
ISN35_07940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN35_07950	COG0534	Mate efflux family protein
ISN35_07955	COG0616	signal peptide processing
ISN35_07965	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_07980	COG0009	L-threonylcarbamoyladenylate synthase
ISN35_07985	COG1754	DNA topoisomerase type I activity
ISN35_07985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN35_07990	COG1714	RDD family
ISN35_08005	COG0758	DNA mediated transformation
ISN35_08010	COG1652	LysM domain
ISN35_08015	COG0242	peptide deformylase activity
ISN35_08020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN35_08025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN35_08025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN35_08030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN35_08065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN35_08070	COG1247	-acetyltransferase
ISN35_08080	COG1490	D-aminoacyl-tRNA deacylase activity
ISN35_08085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN35_08115	COG1609	Transcriptional regulator
ISN35_08125	COG0366	Alpha amylase catalytic
ISN35_08130	COG0366	Alpha amylase catalytic
ISN35_08180	COG1309	transcriptional regulator
ISN35_08220	COG0840	transmembrane signaling receptor activity
ISN35_08240	COG3546	catalase activity
ISN35_08245	COG3685	Protein conserved in bacteria
ISN35_08250	COG3685	Protein conserved in bacteria
ISN35_08260	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_08270	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN35_08285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN35_08300	COG0028	Belongs to the TPP enzyme family
ISN35_08305	COG4191	Histidine kinase
ISN35_08310	COG2204	response regulator
ISN35_08335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN35_08340	COG0732	type I restriction modification DNA specificity domain
ISN35_08365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN35_08365	COG1648	precorrin-2 dehydrogenase activity
ISN35_08375	COG1116	anion transmembrane transporter activity
ISN35_08375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN35_08380	COG2223	nitrite transmembrane transporter activity
ISN35_08385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN35_08390	COG2146	nitrite reductase [NAD(P)H] activity
ISN35_08395	COG0243	molybdopterin cofactor binding
ISN35_08420	COG1640	4-alpha-glucanotransferase
ISN35_08425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN35_08445	COG0745	RESPONSE REGULATOR receiver
ISN35_08470	COG0181	hydroxymethylbilane synthase activity
ISN35_08485	COG1733	regulation of RNA biosynthetic process
ISN35_08500	COG1505	serine-type exopeptidase activity
ISN35_08515	COG0436	Aminotransferase
ISN35_08530	COG2832	Protein of unknown function (DUF454)
ISN35_08540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN35_08560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISN35_08585	COG2226	methyltransferase
ISN35_08590	COG0308	aminopeptidase N
ISN35_08595	COG0596	Alpha beta hydrolase
ISN35_08595	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN35_08615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN35_08620	COG1077	Cell shape determining protein MreB Mrl
ISN35_08625	COG1792	Involved in formation and maintenance of cell shape
ISN35_08635	COG0768	penicillin binding
ISN35_08640	COG0772	Belongs to the SEDS family
ISN35_08655	COG2951	lytic endotransglycosylase activity
ISN35_08665	COG1686	Belongs to the peptidase S11 family
ISN35_08695	COG0321	lipoyl(octanoyl) transferase activity
ISN35_08700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN35_08725	COG1051	belongs to the nudix hydrolase family
ISN35_08725	COG1056	cytidyltransferase-related domain
ISN35_08760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN35_08765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN35_08770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN35_08775	COG1561	YicC-like family, N-terminal region
ISN35_08780	COG0194	GDP metabolic process
ISN35_08785	COG1758	RNA polymerase activity
ISN35_08790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN35_08815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN35_08825	COG0254	rRNA binding
ISN35_08830	COG0372	Belongs to the citrate synthase family
ISN35_08845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN35_08865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN35_08870	COG0667	Aldo Keto reductase
ISN35_08880	COG4771	TonB-dependent receptor
ISN35_08900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN35_08905	COG4181	ATPase activity
ISN35_08920	COG0642	Histidine kinase
ISN35_08930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN35_08935	COG0861	Integral membrane protein TerC family
ISN35_08940	COG1704	LemA family
ISN35_08975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN35_08980	COG2967	ApaG domain
ISN35_08985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN35_08990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN35_08995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN35_09000	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN35_09010	COG2096	Adenosyltransferase
ISN35_09020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN35_09025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN35_09065	COG0697	spore germination
ISN35_09070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN35_09100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN35_09105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN35_09115	COG0583	DNA-binding transcription factor activity
ISN35_09120	COG3634	alkyl hydroperoxide reductase activity
ISN35_09165	COG0488	(ABC) transporter
ISN35_09215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN35_09220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN35_09235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN35_09245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN35_09255	COG0193	aminoacyl-tRNA hydrolase activity
ISN35_09260	COG0012	GTP binding
ISN35_09280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN35_09290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN35_09295	COG0250	Participates in transcription elongation, termination and antitermination
ISN35_09300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN35_09315	COG0222	ribosome binding
ISN35_09325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN35_09340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN35_09345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN35_09350	COG0051	transcription antitermination factor activity, RNA binding
ISN35_09360	COG0088	Forms part of the polypeptide exit tunnel
ISN35_09365	COG0089	rRNA binding
ISN35_09370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN35_09395	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN35_09400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN35_09410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN35_09415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN35_09445	COG1841	ribosomal large subunit assembly
ISN35_09455	COG0201	protein transport
ISN35_09480	COG0203	ribosomal protein L17
ISN35_09485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN35_09495	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN35_09510	COG1217	gtp-binding protein TYPA
ISN35_09515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN35_09525	COG0039	L-malate dehydrogenase activity
ISN35_09540	COG0625	glutathione transferase activity
ISN35_09585	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN35_09585	COG1902	pentaerythritol trinitrate reductase activity
ISN35_09595	COG0667	Aldo Keto reductase
ISN35_09610	COG2814	Major facilitator Superfamily
ISN35_09620	COG2885	chlorophyll binding
ISN35_09635	COG0156	8-amino-7-oxononanoate synthase activity
ISN35_09640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN35_09645	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN35_09650	COG4208	sulfate ABC transporter
ISN35_09655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN35_09675	COG0588	phosphoglycerate mutase activity
ISN35_09680	COG0285	dihydrofolate synthase activity
ISN35_09700	COG2833	Protein of unknown function (DUF455)
ISN35_09705	COG3291	Pkd domain containing protein
ISN35_09715	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN35_09725	COG0438	transferase activity, transferring glycosyl groups
ISN35_09730	COG0248	Ppx GppA phosphatase
ISN35_09735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN35_09750	COG4783	chaperone-mediated protein folding
ISN35_09765	COG0473	3-isopropylmalate dehydrogenase activity
ISN35_09805	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN35_09815	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN35_09850	COG3942	CHAP domain
ISN35_09850	COG1388	LysM domain
ISN35_09855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN35_09865	COG0328	RNA-DNA hybrid ribonuclease activity
ISN35_09870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN35_09875	COG0631	protein serine/threonine phosphatase activity
ISN35_09895	COG0859	PFAM glycosyl transferase family 9
ISN35_09905	COG1234	tRNA 3'-trailer cleavage
ISN35_09910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN35_09920	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN35_09925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN35_09930	COG0314	molybdopterin synthase activity
ISN35_09970	COG0537	adenosine 5'-monophosphoramidase activity
ISN35_09990	COG0714	Associated with various cellular activities
ISN35_10015	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN35_10025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN35_10030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN35_10035	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_10040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN35_10050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN35_10055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN35_10060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN35_10090	COG4115	mRNA cleavage
ISN35_10095	COG2161	toxin-antitoxin pair type II binding
ISN35_10130	COG0587	DNA-directed DNA polymerase activity
ISN35_10145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN35_10150	COG0372	Belongs to the citrate synthase family
ISN35_10190	COG2373	Large extracellular alpha-helical protein
ISN35_10210	COG4953	penicillin-binding protein 1C
ISN35_10220	COG0678	peroxiredoxin activity
ISN35_10245	COG0604	alcohol dehydrogenase
ISN35_10250	COG0330	HflC and HflK could
ISN35_10255	COG0330	HflC and HflK could
ISN35_10265	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN35_10280	COG2801	Transposase and inactivated derivatives
ISN35_10320	COG3459	Glycosyltransferase 36 associated
ISN35_10330	COG1063	alcohol dehydrogenase
ISN35_10345	COG4106	trans-aconitate 2-methyltransferase activity
ISN35_10355	COG0753	catalase activity
ISN35_10365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN35_10365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN35_10385	COG2814	Major facilitator Superfamily
ISN35_10405	COG2194	sulfuric ester hydrolase activity
ISN35_10415	COG0745	RESPONSE REGULATOR receiver
ISN35_10420	COG2205	protein histidine kinase activity
ISN35_10430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN35_10435	COG2894	cell division
ISN35_10440	COG0850	regulation of cytokinetic process
ISN35_10450	COG4585	Histidine kinase
ISN35_10470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISN35_10475	COG1216	Glycosyl transferase, family 2
ISN35_10480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN35_10490	COG1199	ATP-dependent helicase activity
ISN35_10510	COG0189	ligase activity
ISN35_10525	COG0835	chemotaxis
ISN35_10530	COG0840	transmembrane signaling receptor activity
ISN35_10535	COG0784	Response regulator, receiver
ISN35_10535	COG2198	Histidine kinase
ISN35_10535	COG0643	Histidine kinase
ISN35_10540	COG2201	protein-glutamate methylesterase activity
ISN35_10550	COG3209	COG3209 Rhs family protein
ISN35_10555	COG1446	asparaginase
ISN35_10560	COG3142	Participates in the control of copper homeostasis
ISN35_10580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISN35_10600	COG0217	transcriptional regulatory protein
ISN35_10610	COG0632	four-way junction helicase activity
ISN35_10615	COG3158	transport of potassium into the cell
ISN35_10620	COG2255	four-way junction helicase activity
ISN35_10625	COG0824	Thioesterase
ISN35_10635	COG0848	biopolymer transport protein
ISN35_10650	COG2885	chlorophyll binding
ISN35_10660	COG0602	queuosine metabolic process
ISN35_10665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN35_10685	COG0514	ATP-dependent DNA helicase (RecQ)
ISN35_10690	COG0783	Belongs to the Dps family
ISN35_10695	COG1643	Atp-dependent helicase
ISN35_10740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN35_10785	COG4638	Rieske (2fe-2S)
ISN35_10800	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN35_10805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN35_10815	COG1946	Acyl-CoA thioesterase
ISN35_10820	COG1024	Enoyl-CoA hydratase
ISN35_10830	COG0824	Thioesterase
ISN35_10835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN35_10840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN35_10845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN35_10865	COG0728	peptidoglycan biosynthetic process
ISN35_10890	COG0196	riboflavin kinase activity
ISN35_10905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN35_10930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN35_10935	COG1845	cytochrome c oxidase, subunit III
ISN35_10940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN35_10950	COG0156	8-amino-7-oxononanoate synthase activity
ISN35_10960	COG3152	Membrane
ISN35_10990	COG0745	RESPONSE REGULATOR receiver
ISN35_11020	COG4794	Type iii secretion
ISN35_11045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN35_11070	COG1317	bacterial-type flagellum organization
ISN35_11090	COG2207	Transcriptional regulator
ISN35_11115	COG0129	dihydroxy-acid dehydratase activity
ISN35_11135	COG1012	belongs to the aldehyde dehydrogenase family
ISN35_11140	COG1879	ABC-type sugar transport system periplasmic component
ISN35_11145	COG1129	ABC transporter
ISN35_11150	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN35_11155	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN35_11165	COG1082	Xylose isomerase domain protein TIM barrel
ISN35_11170	COG0625	glutathione transferase activity
ISN35_11185	COG0475	glutathione-regulated potassium exporter activity
ISN35_11210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN35_11215	COG2070	2-Nitropropane dioxygenase
ISN35_11230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN35_11235	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN35_11240	COG0335	large ribosomal subunit rRNA binding
ISN35_11245	COG0534	Mate efflux family protein
ISN35_11255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN35_11275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN35_11290	COG2855	membrane
ISN35_11320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN35_11325	COG0481	GTPase activity
ISN35_11330	COG0681	Belongs to the peptidase S26 family
ISN35_11345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN35_11355	COG0745	RESPONSE REGULATOR receiver
ISN35_11365	COG2954	triphosphatase activity
ISN35_11375	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN35_11380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN35_11385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN35_11390	COG1278	Cold shock
ISN35_11395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN35_11405	COG1201	RNA secondary structure unwinding
ISN35_11410	COG1793	dna ligase
ISN35_11410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN35_11415	COG1793	dna ligase
ISN35_11415	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN35_11450	COG0443	Heat shock 70 kDa protein
ISN35_11460	COG0183	Belongs to the thiolase family
ISN35_11490	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN35_11490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN35_11490	COG1703	isobutyryl-CoA mutase activity
ISN35_11555	COG3250	beta-galactosidase activity
ISN35_11560	COG2186	Transcriptional regulator
ISN35_11570	COG0784	Response regulator, receiver
ISN35_11570	COG2198	Histidine kinase
ISN35_11570	COG2205	protein histidine kinase activity
ISN35_11595	COG1451	nucleotide metabolic process
ISN35_11605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN35_11640	COG1077	Cell shape determining protein MreB Mrl
ISN35_11645	COG1047	Peptidyl-prolyl cis-trans
ISN35_11650	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN35_11655	COG1902	pentaerythritol trinitrate reductase activity
ISN35_11665	COG2814	Major facilitator Superfamily
ISN35_11695	COG0392	lysyltransferase activity
ISN35_11695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN35_11705	COG0251	oxidation-reduction process
ISN35_11725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN35_11750	COG1595	DNA-templated transcription, initiation
ISN35_11765	COG2878	Part of a membrane complex involved in electron transport
ISN35_11785	COG0346	lactoylglutathione lyase activity
ISN35_11795	COG0833	amino acid
ISN35_11800	COG2040	homocysteine
ISN35_11810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN35_11830	COG3118	belongs to the thioredoxin family
ISN35_11840	COG0495	leucyl-tRNA aminoacylation
ISN35_11855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN35_11870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN35_11885	COG2968	Membrane
ISN35_11905	COG0312	modulator of DNA gyrase
ISN35_11915	COG0312	modulator of DNA gyrase
ISN35_12015	COG0631	protein serine/threonine phosphatase activity
ISN35_12020	COG0515	serine threonine protein kinase
ISN35_12020	COG2815	serine threonine protein kinase
ISN35_12045	COG1858	cytochrome C peroxidase
ISN35_12055	COG0142	geranyltranstransferase activity
ISN35_12060	COG1722	exodeoxyribonuclease VII activity
ISN35_12065	COG0037	tRNA processing
ISN35_12075	COG1785	Belongs to the alkaline phosphatase family
ISN35_12080	COG1301	dicarboxylic acid transport
ISN35_12090	COG1607	acyl-coa hydrolase
ISN35_12105	COG0791	NLP P60 protein
ISN35_12110	COG0791	NLP P60 protein
ISN35_12115	COG1047	Peptidyl-prolyl cis-trans
ISN35_12120	COG2311	Membrane
ISN35_12125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN35_12145	COG0697	spore germination
ISN35_12175	COG3590	peptidase
ISN35_12190	COG0457	Tetratricopeptide repeat
ISN35_12195	COG4771	TonB-dependent receptor
ISN35_12200	COG4771	TonB-dependent receptor
ISN35_12210	COG0489	protein tyrosine kinase activity
ISN35_12215	COG0717	Belongs to the dCTP deaminase family
ISN35_12220	COG1714	RDD family
ISN35_12240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN35_12255	COG0494	nUDIX hydrolase
ISN35_12260	COG0433	COG0433 Predicted ATPase
ISN35_12265	COG0741	lytic transglycosylase activity
ISN35_12270	COG0688	phosphatidylethanolamine metabolic process
ISN35_12280	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN35_12295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISN35_12340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN35_12365	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_12385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN35_12395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN35_12400	COG0649	NAD binding
ISN35_12405	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN35_12410	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN35_12415	COG1034	ATP synthesis coupled electron transport
ISN35_12435	COG0713	ATP synthesis coupled electron transport
ISN35_12450	COG1007	ATP synthesis coupled electron transport
ISN35_12465	COG0195	Participates in both transcription termination and antitermination
ISN35_12490	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN35_12495	COG3300	MHYT domain
ISN35_12495	COG5001	Diguanylate cyclase
ISN35_12515	COG0840	transmembrane signaling receptor activity
ISN35_12520	COG0840	transmembrane signaling receptor activity
ISN35_12525	COG0835	chemotaxis
ISN35_12570	COG1194	a g-specific adenine glycosylase
ISN35_12575	COG0552	protein localization to endoplasmic reticulum
ISN35_12585	COG3938	Belongs to the proline racemase family
ISN35_12590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN35_12605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN35_12615	COG0006	proline dipeptidase activity
ISN35_12630	COG0531	amino acid
ISN35_12665	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN35_12675	COG4771	TonB-dependent receptor
ISN35_12700	COG0742	ribosomal rna small subunit methyltransferase
ISN35_12715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN35_12720	COG0405	Gamma-glutamyltransferase
ISN35_12725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN35_12730	COG3291	Pkd domain containing protein
ISN35_12735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN35_12745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN35_12755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN35_12765	COG1862	Preprotein translocase
ISN35_12770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN35_12795	COG3706	GGDEF domain
ISN35_12795	COG4251	negative regulation of phosphorylation
ISN35_12795	COG5001	Diguanylate cyclase
ISN35_12795	COG2203	Gaf domain
ISN35_12800	COG1509	lysine 2,3-aminomutase activity
ISN35_12810	COG3548	integral membrane protein
ISN35_12815	COG0402	S-adenosylhomocysteine deaminase activity
ISN35_12835	COG4677	pectinesterase activity
ISN35_12845	COG4677	pectinesterase activity
ISN35_12855	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN35_12925	COG2166	iron-sulfur cluster assembly
ISN35_12940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN35_12945	COG0137	argininosuccinate synthase activity
ISN35_12950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN35_12955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN35_12965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN35_12970	COG0165	Argininosuccinate lyase
ISN35_12990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN35_12995	COG2801	Transposase and inactivated derivatives
ISN35_13010	COG1070	Carbohydrate kinase
ISN35_13015	COG2115	Belongs to the xylose isomerase family
ISN35_13020	COG0477	Major facilitator Superfamily
ISN35_13025	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN35_13045	COG0617	tRNA 3'-terminal CCA addition
ISN35_13055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN35_13070	COG0166	Belongs to the GPI family
ISN35_13135	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN35_13150	COG0671	phosphoesterase, PA-phosphatase related
ISN35_13175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN35_13180	COG0167	dihydroorotate dehydrogenase activity
ISN35_13195	COG1012	belongs to the aldehyde dehydrogenase family
ISN35_13210	COG0527	aspartate kinase activity
ISN35_13210	COG0460	homoserine dehydrogenase
ISN35_13215	COG0083	homoserine kinase activity
ISN35_13220	COG2951	lytic endotransglycosylase activity
ISN35_13230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN35_13240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN35_13245	COG0124	histidyl-tRNA synthetase
ISN35_13255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN35_13260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN35_13275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN35_13290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN35_13290	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN35_13305	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN35_13310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN35_13315	COG0235	Class ii aldolase
ISN35_13320	COG0531	amino acid
ISN35_13325	COG0531	amino acid
ISN35_13340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN35_13345	COG0277	FAD linked oxidase domain protein
ISN35_13365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN35_13380	COG1024	Enoyl-CoA hydratase
ISN35_13410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN35_13420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN35_13425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN35_13475	COG0438	transferase activity, transferring glycosyl groups
ISN35_13480	COG0438	transferase activity, transferring glycosyl groups
ISN35_13490	COG0438	transferase activity, transferring glycosyl groups
ISN35_13510	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN35_13520	COG1960	acyl-CoA dehydrogenase activity
ISN35_13570	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN35_13575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN35_13575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN35_13580	COG0802	atpase or kinase
ISN35_13585	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN35_13590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN35_13610	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_13630	COG2081	HI0933 family
ISN35_13635	COG4681	YaeQ
ISN35_13640	COG0564	pseudouridine synthase activity
ISN35_13650	COG0625	glutathione transferase activity
ISN35_13660	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN35_13685	COG0513	Belongs to the DEAD box helicase family
ISN35_13690	COG0488	(ABC) transporter
ISN35_13700	COG4290	ribonuclease
ISN35_13705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN35_13755	COG1846	Transcriptional regulator
ISN35_13770	COG0386	Belongs to the glutathione peroxidase family
ISN35_13795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISN35_13845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN35_13850	COG0084	hydrolase, TatD family'
ISN35_13865	COG1960	acyl-CoA dehydrogenase activity
ISN35_13875	COG0305	Participates in initiation and elongation during chromosome replication
ISN35_13880	COG0415	Belongs to the DNA photolyase family
ISN35_13895	COG0583	DNA-binding transcription factor activity
ISN35_13910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN35_13945	COG1404	Belongs to the peptidase S8 family
ISN35_13955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN35_13960	COG2867	negative regulation of translational initiation
ISN35_13970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN35_13975	COG0735	belongs to the Fur family
ISN35_13980	COG0497	DNA recombination
ISN35_13985	COG1420	regulation of RNA biosynthetic process
ISN35_13990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN35_13995	COG0443	Heat shock 70 kDa protein
ISN35_14000	COG0484	heat shock protein binding
ISN35_14005	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN35_14010	COG1605	Chorismate mutase
ISN35_14010	COG0287	Prephenate dehydrogenase
ISN35_14020	COG1132	(ABC) transporter
ISN35_14070	COG2850	peptidyl-arginine hydroxylation
ISN35_14075	COG2885	chlorophyll binding
ISN35_14120	COG1131	(ABC) transporter
ISN35_14125	COG1725	Transcriptional regulator
ISN35_14135	COG0386	Belongs to the glutathione peroxidase family
ISN35_14150	COG2900	Belongs to the SlyX family
ISN35_14160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN35_14160	COG2755	lipolytic protein G-D-S-L family
ISN35_14170	COG1410	methionine synthase
ISN35_14170	COG0646	methionine synthase
ISN35_14175	COG1410	methionine synthase
ISN35_14175	COG0646	methionine synthase
ISN35_14180	COG2226	methyltransferase
ISN35_14185	COG1960	acyl-CoA dehydrogenase activity
ISN35_14240	COG0556	nucleotide-excision repair
ISN35_14255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN35_14260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN35_14270	COG2902	Dehydrogenase
ISN35_14295	COG1294	oxidase, subunit
ISN35_14305	COG4988	ABC transporter
ISN35_14310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN35_14315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN35_14360	COG4133	protoheme IX ABC transporter activity
ISN35_14365	COG0436	Aminotransferase
ISN35_14390	COG1187	pseudouridine synthase activity
ISN35_14395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN35_14400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN35_14405	COG2350	Protein conserved in bacteria
ISN35_14440	COG0395	ABC-type sugar transport system, permease component
ISN35_14455	COG0129	dihydroxy-acid dehydratase activity
ISN35_14470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN35_14490	COG2009	succinate dehydrogenase
ISN35_14495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN35_14505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISN35_14510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN35_14520	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN35_14540	COG0811	peptide transport
ISN35_14550	COG1132	(ABC) transporter
ISN35_14555	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN35_14565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN35_14580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN35_14615	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN35_14620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN35_14630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN35_14670	COG1132	(ABC) transporter
ISN35_14695	COG1530	ribonuclease E activity
ISN35_14710	COG0428	transporter
ISN35_14725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN35_14725	COG0316	Belongs to the HesB IscA family
ISN35_14745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN35_14765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN35_14770	COG2957	Belongs to the agmatine deiminase family
ISN35_14780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN35_14785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN35_14790	COG0539	negative regulation of cytoplasmic translation
ISN35_14795	COG0776	regulation of translation
ISN35_14805	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN35_14810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN35_14820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN35_14825	COG0183	Belongs to the thiolase family
ISN35_14830	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN35_14830	COG1024	Enoyl-CoA hydratase
ISN35_14845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN35_14855	COG1426	Protein conserved in bacteria
ISN35_14865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN35_14875	COG0746	molybdenum cofactor guanylyltransferase activity
ISN35_14885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN35_14890	COG0475	glutathione-regulated potassium exporter activity
ISN35_14890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN35_14910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN35_14920	COG0519	Catalyzes the synthesis of GMP from XMP
ISN35_14920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN35_14925	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN35_14930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN35_14940	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN35_14955	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN35_14960	COG0668	transmembrane transport
ISN35_14970	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN35_14985	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_14990	COG1183	phosphatidylcholine synthase activity
ISN35_15000	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN35_15020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN35_15020	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN35_15030	COG0784	Response regulator, receiver
ISN35_15030	COG4191	Histidine kinase
ISN35_15035	COG2183	response to ionizing radiation
ISN35_15040	COG2205	protein histidine kinase activity
ISN35_15040	COG0784	Response regulator, receiver
ISN35_15110	COG1649	PFAM Uncharacterised BCR, COG1649
ISN35_15120	COG1304	FMN binding
ISN35_15130	COG0346	lactoylglutathione lyase activity
ISN35_15175	COG1024	Enoyl-CoA hydratase
ISN35_15180	COG1024	Enoyl-CoA hydratase
ISN35_15190	COG1024	Enoyl-CoA hydratase
ISN35_15205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN35_15210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN35_15420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN35_15425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN35_15435	COG0505	Belongs to the CarA family
ISN35_15445	COG2258	MOSC domain
ISN35_15450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN35_15460	COG0438	transferase activity, transferring glycosyl groups
ISN35_15465	COG0438	transferase activity, transferring glycosyl groups
ISN35_15485	COG4106	trans-aconitate 2-methyltransferase activity
ISN35_15505	COG2244	polysaccharide biosynthetic process
ISN35_15535	COG3038	cytochrome b561
ISN35_15555	COG1595	DNA-templated transcription, initiation
ISN35_15610	COG0038	chloride channel
ISN35_15615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN35_15635	COG1674	ftsk spoiiie
ISN35_15640	COG0492	ferredoxin-NADP+ reductase activity
ISN35_15650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISN35_15660	COG0542	response to heat
ISN35_15680	COG0482	sulfurtransferase activity
ISN35_15685	COG2915	High frequency lysogenization protein hflD homolog
ISN35_15750	COG0784	Response regulator, receiver
ISN35_15750	COG0835	chemotaxis
ISN35_15760	COG1558	bacterial-type flagellum-dependent cell motility
ISN35_15770	COG1749	Flagellar hook protein flgE
ISN35_15785	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN35_15800	COG4786	Flagellar basal body rod
ISN35_15800	COG1256	bacterial-type flagellum assembly
ISN35_15800	COG4786	Flagellar basal body rod
ISN35_15800	COG1256	bacterial-type flagellum assembly
ISN35_15805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN35_15810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN35_15815	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN35_15835	COG2197	response regulator
ISN35_15845	COG2201	protein-glutamate methylesterase activity
ISN35_15865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN35_15875	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_15910	COG1677	Flagellar hook-basal body complex protein FliE
ISN35_15960	COG3190	flagellar
ISN35_15970	COG1987	bacterial-type flagellum assembly
ISN35_15975	COG1684	flagellar biosynthetic protein fliR
ISN35_16020	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN35_16025	COG2198	Histidine kinase
ISN35_16025	COG0784	Response regulator, receiver
ISN35_16025	COG0643	Histidine kinase
ISN35_16030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN35_16040	COG1192	Involved in chromosome partitioning
ISN35_16045	COG0835	chemotaxis
ISN35_16055	COG0745	RESPONSE REGULATOR receiver
ISN35_16070	COG0840	transmembrane signaling receptor activity
ISN35_16075	COG0840	transmembrane signaling receptor activity
ISN35_16080	COG0840	transmembrane signaling receptor activity
ISN35_16085	COG0840	transmembrane signaling receptor activity
ISN35_16095	COG0840	transmembrane signaling receptor activity
ISN35_16105	COG0840	transmembrane signaling receptor activity
ISN35_16110	COG0840	transmembrane signaling receptor activity
ISN35_16115	COG0840	transmembrane signaling receptor activity
ISN35_16125	COG0840	transmembrane signaling receptor activity
ISN35_16135	COG0835	chemotaxis
ISN35_16145	COG0840	transmembrane signaling receptor activity
ISN35_16155	COG0840	transmembrane signaling receptor activity
ISN35_16215	COG0318	PFAM AMP-dependent synthetase and ligase
ISN35_16220	COG1024	Enoyl-CoA hydratase
ISN35_16225	COG0784	Response regulator, receiver
ISN35_16225	COG2198	Histidine kinase
ISN35_16225	COG2205	protein histidine kinase activity
ISN35_16260	COG0800	Aldolase
ISN35_16275	COG3734	2-keto-3-deoxy-galactonokinase
ISN35_16280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN35_16295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN35_16305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN35_16310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN35_16350	COG0351	phosphomethylpyrimidine kinase
ISN35_16350	COG0352	thiamine-phosphate diphosphorylase activity
ISN35_16370	COG0583	DNA-binding transcription factor activity
ISN35_16375	COG1741	Belongs to the pirin family
ISN35_16400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISN35_16410	COG2137	regulation of response to DNA damage stimulus
ISN35_16415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN35_16420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN35_16425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN35_16430	COG1546	Belongs to the CinA family
ISN35_16435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN35_16445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN35_16450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN35_16455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN35_16460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN35_16465	COG1534	Rna-binding protein
ISN35_16480	COG1238	metal cluster binding
ISN35_16490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN35_16505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN35_16510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN35_16530	COG0504	CTP synthase activity
ISN35_16550	COG0306	phosphate transporter
ISN35_16560	COG1253	flavin adenine dinucleotide binding
ISN35_16575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN35_16610	COG0069	glutamate synthase activity
ISN35_16615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN35_16625	COG1609	Transcriptional regulator
ISN35_16630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN35_16630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN35_16635	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN35_16640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN35_16640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN35_16675	COG1136	(ABC) transporter
ISN35_16675	COG0577	efflux transmembrane transporter activity
ISN35_16745	COG0583	DNA-binding transcription factor activity
ISN35_16770	COG0077	Prephenate dehydratase
ISN35_16770	COG1605	Chorismate mutase
ISN35_16775	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN35_16780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN35_16820	COG4221	oxidoreductase activity
ISN35_16835	COG1228	amidohydrolase
ISN35_16850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN35_16865	COG1309	transcriptional regulator
ISN35_16885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN35_16895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN35_16900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN35_16905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN35_16940	COG0316	Belongs to the HesB IscA family
ISN35_16965	COG2197	response regulator
ISN35_17010	COG0288	reversible hydration of carbon dioxide
ISN35_17025	COG3844	kynureninase activity
ISN35_17035	COG2925	Exonuclease
ISN35_17120	COG3275	phosphorelay sensor kinase activity
ISN35_17125	COG1611	Belongs to the LOG family
ISN35_17135	COG2095	MarC family integral membrane protein
ISN35_17140	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_17145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN35_17185	COG2969	positive regulation of protein catabolic process
ISN35_17190	COG0625	glutathione transferase activity
ISN35_17195	COG2857	Cytochrome c1
ISN35_17205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN35_17210	COG0723	plastoquinol--plastocyanin reductase activity
ISN35_17215	COG0741	lytic transglycosylase activity
ISN35_17230	COG1702	phosphate starvation-inducible protein PhoH
ISN35_17245	COG4535	Mg2 and Co2 transporter CorC
ISN35_17260	COG1012	belongs to the aldehyde dehydrogenase family
ISN35_17265	COG1177	transmembrane transport
ISN35_17270	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN35_17275	COG3842	ATPase activity
ISN35_17300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISN35_17315	COG0174	glutamine synthetase
ISN35_17320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN35_17325	COG0174	glutamine synthetase
ISN35_17330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN35_17340	COG0477	Major facilitator Superfamily
ISN35_17355	COG0243	molybdopterin cofactor binding
ISN35_17365	COG2223	nitrite transmembrane transporter activity
ISN35_17390	COG1012	belongs to the aldehyde dehydrogenase family
ISN35_17395	COG1917	Cupin 2, conserved barrel domain protein
ISN35_17395	COG1396	sequence-specific DNA binding
ISN35_17400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN35_17405	COG0686	Belongs to the AlaDH PNT family
ISN35_17425	COG2733	membrane
ISN35_17430	COG0784	Response regulator, receiver
ISN35_17430	COG5002	protein histidine kinase activity
ISN35_17430	COG2205	protein histidine kinase activity
ISN35_17490	COG1024	Enoyl-CoA hydratase
ISN35_17500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN35_17505	COG0659	secondary active sulfate transmembrane transporter activity
ISN35_17525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN35_17530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN35_17540	COG0581	inorganic phosphate transmembrane transporter activity
ISN35_17550	COG0704	Plays a role in the regulation of phosphate uptake
ISN35_17570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN35_17590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN35_17600	COG0557	exoribonuclease II activity
ISN35_17635	COG2814	Major facilitator Superfamily
ISN35_17640	COG1566	PFAM secretion protein HlyD family protein
ISN35_17680	COG0367	asparagine synthase
ISN35_17690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN35_17695	COG1393	Belongs to the ArsC family
ISN35_17710	COG0024	Methionine aminopeptidase
ISN35_17750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN35_17760	COG0528	UMP kinase activity
ISN35_17770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN35_17775	COG0575	Belongs to the CDS family
ISN35_17780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN35_17785	COG0750	zinc metalloprotease
ISN35_17795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN35_17805	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN35_17810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN35_17835	COG1981	membrane
ISN35_17925	COG1132	(ABC) transporter
ISN35_17945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN35_17970	COG1187	pseudouridine synthase activity
ISN35_18080	COG2080	2 iron, 2 sulfur cluster binding
ISN35_18085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN35_18090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN35_18130	COG0735	belongs to the Fur family
ISN35_18170	COG2205	protein histidine kinase activity
ISN35_18180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN35_18200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN35_18210	COG0643	Histidine kinase
ISN35_18210	COG2198	Histidine kinase
ISN35_18215	COG0840	transmembrane signaling receptor activity
ISN35_18220	COG0840	transmembrane signaling receptor activity
ISN35_18225	COG0840	transmembrane signaling receptor activity
ISN35_18230	COG0835	chemotaxis
ISN35_18255	COG2801	Transposase and inactivated derivatives
ISN35_18265	COG2211	Major facilitator Superfamily
ISN35_18305	COG1966	Carbon starvation protein
ISN35_18310	COG2879	small protein
ISN35_18315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN35_18340	COG0823	Involved in the tonB-independent uptake of proteins
ISN35_18340	COG1506	peptidase
ISN35_18345	COG1297	OPT oligopeptide transporter protein
ISN35_18350	COG3104	oligopeptide transport
ISN35_18370	COG0629	single-stranded DNA binding
ISN35_18375	COG0142	geranyltranstransferase activity
ISN35_18400	COG0527	aspartate kinase activity
ISN35_18405	COG0384	phenazine biosynthesis protein PhzF
ISN35_18415	COG1764	response to oxidative stress
ISN35_18430	COG0739	heme binding
ISN35_18445	COG0693	protein deglycase activity
ISN35_18460	COG0719	Fe-S assembly protein
ISN35_18465	COG0396	ATPase activity
ISN35_18470	COG0719	Fe-S assembly protein
ISN35_18475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN35_18485	COG2146	nitrite reductase [NAD(P)H] activity
ISN35_18490	COG4774	siderophore transport
ISN35_18515	COG1477	protein flavinylation
ISN35_18520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN35_18540	COG1555	photosystem II stabilization
ISN35_18555	COG3178	'Phosphotransferase
ISN35_18560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN35_18570	COG0628	permease
ISN35_18595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN35_18640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN35_18655	COG1137	ATPase activity
ISN35_18670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN35_18680	COG1660	Displays ATPase and GTPase activities
ISN35_18690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN35_18695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN35_18700	COG2239	Acts as a magnesium transporter
ISN35_18720	COG1113	amino acid transport
ISN35_18730	COG0840	transmembrane signaling receptor activity
ISN35_18755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN35_18770	COG0519	Catalyzes the synthesis of GMP from XMP
ISN35_18785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISN35_18830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN35_18845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN35_18850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN35_18860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN35_18865	COG2814	Major facilitator Superfamily
ISN35_18885	COG3038	cytochrome b561
ISN35_18900	COG1760	l-serine dehydratase
ISN35_18915	COG0527	aspartate kinase activity
ISN35_18915	COG0460	homoserine dehydrogenase
ISN35_18920	COG0626	cystathionine gamma-synthase activity
ISN35_18925	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN35_18935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN35_18940	COG1272	protein, Hemolysin III
ISN35_18945	COG2982	Protein involved in outer membrane biogenesis
ISN35_18950	COG0517	IMP dehydrogenase activity
ISN35_18955	COG0463	Glycosyl transferase, family 2
ISN35_18960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN35_18965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN35_19000	COG1304	FMN binding
ISN35_19010	COG1657	PFAM Prenyltransferase squalene oxidase
ISN35_19015	COG0142	geranyltranstransferase activity
ISN35_19020	COG2124	cytochrome p450
ISN35_19025	COG1028	Short-chain dehydrogenase reductase Sdr
ISN35_19030	COG1141	Ferredoxin
ISN35_19035	COG2124	cytochrome p450
ISN35_19040	COG2124	cytochrome p450
ISN35_19110	COG0330	HflC and HflK could
ISN35_19120	COG1742	UPF0060 membrane protein
ISN35_19125	COG3956	TIGRFAM MazG family protein
ISN35_19130	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN35_19135	COG0494	nUDIX hydrolase
ISN35_19145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN35_19155	COG0837	glucose binding
ISN35_19170	COG3858	chitin binding
ISN35_19170	COG1388	LysM domain
ISN35_19175	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN35_19185	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN35_19205	COG3537	Alpha-1,2-mannosidase
ISN35_19375	COG3179	chitinase
ISN35_19450	COG4682	membrane
ISN35_19515	COG3209	COG3209 Rhs family protein
ISN35_19600	COG0521	Mo-molybdopterin cofactor biosynthetic process