locus-tag	class	description
ISN36_00030	COG1064	alcohol dehydrogenase
ISN36_00035	COG2234	aminopeptidase activity
ISN36_00045	COG4942	peptidase
ISN36_00050	COG0793	Belongs to the peptidase S41A family
ISN36_00080	COG0531	amino acid
ISN36_00105	COG1565	acr, cog1565
ISN36_00105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN36_00110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN36_00115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN36_00145	COG0109	protoheme IX farnesyltransferase activity
ISN36_00160	COG0358	DNA primase activity
ISN36_00165	COG1295	ribonuclease BN
ISN36_00185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN36_00190	COG2308	Evidence 4 Homologs of previously reported genes of
ISN36_00205	COG2133	pyrroloquinoline quinone binding
ISN36_00225	COG0531	amino acid
ISN36_00235	COG4948	Mandelate Racemase Muconate Lactonizing
ISN36_00245	COG4771	TonB-dependent receptor
ISN36_00250	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISN36_00300	COG5383	Protein conserved in bacteria
ISN36_00315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN36_00320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN36_00335	COG1652	LysM domain
ISN36_00345	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN36_00350	COG1518	maintenance of DNA repeat elements
ISN36_00395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN36_00425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN36_00430	COG3118	belongs to the thioredoxin family
ISN36_00440	COG2884	Cell division ATP-binding protein ftsE
ISN36_00445	COG2177	Part of the ABC transporter FtsEX involved in
ISN36_00450	COG2201	protein-glutamate methylesterase activity
ISN36_00455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN36_00460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN36_00465	COG2860	membrane
ISN36_00470	COG1252	NADH dehydrogenase
ISN36_00480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN36_00490	COG0534	Mate efflux family protein
ISN36_00495	COG0616	signal peptide processing
ISN36_00505	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_00525	COG0009	L-threonylcarbamoyladenylate synthase
ISN36_00530	COG1754	DNA topoisomerase type I activity
ISN36_00530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN36_00535	COG1714	RDD family
ISN36_00550	COG0758	DNA mediated transformation
ISN36_00555	COG1652	LysM domain
ISN36_00560	COG0242	peptide deformylase activity
ISN36_00565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN36_00570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN36_00570	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN36_00575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN36_00610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN36_00615	COG1247	-acetyltransferase
ISN36_00625	COG1490	D-aminoacyl-tRNA deacylase activity
ISN36_00630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN36_00660	COG1609	Transcriptional regulator
ISN36_00670	COG0366	Alpha amylase catalytic
ISN36_00675	COG0366	Alpha amylase catalytic
ISN36_00725	COG1309	transcriptional regulator
ISN36_00765	COG0840	transmembrane signaling receptor activity
ISN36_00780	COG3546	catalase activity
ISN36_00785	COG3685	Protein conserved in bacteria
ISN36_00790	COG3685	Protein conserved in bacteria
ISN36_00795	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_00805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN36_00820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN36_00835	COG0028	Belongs to the TPP enzyme family
ISN36_00840	COG4191	Histidine kinase
ISN36_00870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN36_00875	COG0732	type I restriction modification DNA specificity domain
ISN36_00900	COG1648	precorrin-2 dehydrogenase activity
ISN36_00900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN36_00910	COG1116	anion transmembrane transporter activity
ISN36_00910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN36_00915	COG2223	nitrite transmembrane transporter activity
ISN36_00920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN36_00925	COG2146	nitrite reductase [NAD(P)H] activity
ISN36_00930	COG0243	molybdopterin cofactor binding
ISN36_00955	COG1640	4-alpha-glucanotransferase
ISN36_00960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN36_00980	COG0745	RESPONSE REGULATOR receiver
ISN36_01005	COG0181	hydroxymethylbilane synthase activity
ISN36_01020	COG1733	regulation of RNA biosynthetic process
ISN36_01035	COG1505	serine-type exopeptidase activity
ISN36_01050	COG0436	Aminotransferase
ISN36_01060	COG2832	Protein of unknown function (DUF454)
ISN36_01070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN36_01090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISN36_01115	COG2226	methyltransferase
ISN36_01120	COG0308	aminopeptidase N
ISN36_01125	COG0596	Alpha beta hydrolase
ISN36_01125	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN36_01140	COG3284	Transcriptional regulator
ISN36_01145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN36_01150	COG1077	Cell shape determining protein MreB Mrl
ISN36_01155	COG1792	Involved in formation and maintenance of cell shape
ISN36_01165	COG0768	penicillin binding
ISN36_01170	COG0772	Belongs to the SEDS family
ISN36_01190	COG2951	lytic endotransglycosylase activity
ISN36_01200	COG1686	Belongs to the peptidase S11 family
ISN36_01235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN36_01260	COG1056	cytidyltransferase-related domain
ISN36_01260	COG1051	belongs to the nudix hydrolase family
ISN36_01295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN36_01300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN36_01305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN36_01310	COG1561	YicC-like family, N-terminal region
ISN36_01315	COG0194	GDP metabolic process
ISN36_01320	COG1758	RNA polymerase activity
ISN36_01325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN36_01345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN36_01355	COG0254	rRNA binding
ISN36_01360	COG0372	Belongs to the citrate synthase family
ISN36_01375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN36_01395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN36_01400	COG0667	Aldo Keto reductase
ISN36_01410	COG4771	TonB-dependent receptor
ISN36_01430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN36_01435	COG4181	ATPase activity
ISN36_01450	COG0642	Histidine kinase
ISN36_01460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN36_01465	COG0861	Integral membrane protein TerC family
ISN36_01470	COG1704	LemA family
ISN36_01500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN36_01505	COG2967	ApaG domain
ISN36_01510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN36_01515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN36_01520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN36_01525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN36_01535	COG2096	Adenosyltransferase
ISN36_01545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN36_01550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN36_01590	COG0697	spore germination
ISN36_01595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN36_01625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN36_01630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN36_01640	COG0583	DNA-binding transcription factor activity
ISN36_01645	COG3634	alkyl hydroperoxide reductase activity
ISN36_01685	COG0488	(ABC) transporter
ISN36_01735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN36_01740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN36_01755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN36_01765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN36_01775	COG0193	aminoacyl-tRNA hydrolase activity
ISN36_01780	COG0012	GTP binding
ISN36_01800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN36_01810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN36_01815	COG0250	Participates in transcription elongation, termination and antitermination
ISN36_01820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN36_01835	COG0222	ribosome binding
ISN36_01845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN36_01860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN36_01870	COG0051	transcription antitermination factor activity, RNA binding
ISN36_01880	COG0088	Forms part of the polypeptide exit tunnel
ISN36_01885	COG0089	rRNA binding
ISN36_01890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN36_01915	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN36_01920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN36_01930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN36_01935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN36_01965	COG1841	ribosomal large subunit assembly
ISN36_01975	COG0201	protein transport
ISN36_02000	COG0203	ribosomal protein L17
ISN36_02005	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN36_02015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN36_02030	COG1217	gtp-binding protein TYPA
ISN36_02035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN36_02045	COG0039	L-malate dehydrogenase activity
ISN36_02060	COG0625	glutathione transferase activity
ISN36_02105	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN36_02105	COG1902	pentaerythritol trinitrate reductase activity
ISN36_02115	COG0667	Aldo Keto reductase
ISN36_02130	COG2814	Major facilitator Superfamily
ISN36_02140	COG2885	chlorophyll binding
ISN36_02155	COG0156	8-amino-7-oxononanoate synthase activity
ISN36_02160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN36_02165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN36_02170	COG4208	sulfate ABC transporter
ISN36_02175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN36_02195	COG0588	phosphoglycerate mutase activity
ISN36_02200	COG0285	dihydrofolate synthase activity
ISN36_02220	COG2833	Protein of unknown function (DUF455)
ISN36_02225	COG3291	Pkd domain containing protein
ISN36_02235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN36_02245	COG0438	transferase activity, transferring glycosyl groups
ISN36_02250	COG0248	Ppx GppA phosphatase
ISN36_02255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN36_02270	COG4783	chaperone-mediated protein folding
ISN36_02285	COG0473	3-isopropylmalate dehydrogenase activity
ISN36_02325	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN36_02335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN36_02370	COG3942	CHAP domain
ISN36_02370	COG1388	LysM domain
ISN36_02375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN36_02385	COG0328	RNA-DNA hybrid ribonuclease activity
ISN36_02390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN36_02395	COG0631	protein serine/threonine phosphatase activity
ISN36_02415	COG0859	PFAM glycosyl transferase family 9
ISN36_02425	COG1234	tRNA 3'-trailer cleavage
ISN36_02430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN36_02440	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN36_02445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN36_02450	COG0314	molybdopterin synthase activity
ISN36_02490	COG0537	adenosine 5'-monophosphoramidase activity
ISN36_02510	COG0714	Associated with various cellular activities
ISN36_02535	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN36_02545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN36_02550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN36_02555	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_02560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN36_02570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN36_02575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN36_02580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN36_02600	COG4115	mRNA cleavage
ISN36_02605	COG2161	toxin-antitoxin pair type II binding
ISN36_02640	COG0587	DNA-directed DNA polymerase activity
ISN36_02655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN36_02660	COG0372	Belongs to the citrate synthase family
ISN36_02675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN36_02700	COG2373	Large extracellular alpha-helical protein
ISN36_02730	COG0678	peroxiredoxin activity
ISN36_02750	COG0604	alcohol dehydrogenase
ISN36_02755	COG0330	HflC and HflK could
ISN36_02760	COG0330	HflC and HflK could
ISN36_02770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN36_02825	COG3459	Glycosyltransferase 36 associated
ISN36_02835	COG1063	alcohol dehydrogenase
ISN36_02850	COG4106	trans-aconitate 2-methyltransferase activity
ISN36_02860	COG0753	catalase activity
ISN36_02870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN36_02870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN36_02895	COG2814	Major facilitator Superfamily
ISN36_02915	COG2194	sulfuric ester hydrolase activity
ISN36_02925	COG0745	RESPONSE REGULATOR receiver
ISN36_02930	COG2205	protein histidine kinase activity
ISN36_02940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN36_02945	COG2894	cell division
ISN36_02950	COG0850	regulation of cytokinetic process
ISN36_02960	COG4585	Histidine kinase
ISN36_02980	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISN36_02985	COG1216	Glycosyl transferase, family 2
ISN36_02990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN36_03000	COG1199	ATP-dependent helicase activity
ISN36_03020	COG0189	ligase activity
ISN36_03035	COG0835	chemotaxis
ISN36_03040	COG0840	transmembrane signaling receptor activity
ISN36_03045	COG0784	Response regulator, receiver
ISN36_03045	COG2198	Histidine kinase
ISN36_03045	COG0643	Histidine kinase
ISN36_03050	COG2201	protein-glutamate methylesterase activity
ISN36_03070	COG1446	asparaginase
ISN36_03075	COG3142	Participates in the control of copper homeostasis
ISN36_03095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISN36_03115	COG0217	transcriptional regulatory protein
ISN36_03125	COG0632	four-way junction helicase activity
ISN36_03130	COG3158	transport of potassium into the cell
ISN36_03135	COG2255	four-way junction helicase activity
ISN36_03140	COG0824	Thioesterase
ISN36_03150	COG0848	biopolymer transport protein
ISN36_03165	COG2885	chlorophyll binding
ISN36_03175	COG0602	queuosine metabolic process
ISN36_03180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN36_03200	COG0514	ATP-dependent DNA helicase (RecQ)
ISN36_03205	COG0783	Belongs to the Dps family
ISN36_03210	COG1643	Atp-dependent helicase
ISN36_03255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN36_03300	COG4638	Rieske (2fe-2S)
ISN36_03315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN36_03320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN36_03330	COG1946	Acyl-CoA thioesterase
ISN36_03335	COG1024	Enoyl-CoA hydratase
ISN36_03345	COG0824	Thioesterase
ISN36_03350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN36_03355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN36_03360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN36_03375	COG0728	peptidoglycan biosynthetic process
ISN36_03395	COG0196	riboflavin kinase activity
ISN36_03410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN36_03430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN36_03435	COG1845	cytochrome c oxidase, subunit III
ISN36_03440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN36_03450	COG0156	8-amino-7-oxononanoate synthase activity
ISN36_03460	COG3152	Membrane
ISN36_03490	COG0745	RESPONSE REGULATOR receiver
ISN36_03520	COG4794	Type iii secretion
ISN36_03545	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN36_03570	COG1317	bacterial-type flagellum organization
ISN36_03590	COG2207	Transcriptional regulator
ISN36_03615	COG0129	dihydroxy-acid dehydratase activity
ISN36_03635	COG1012	belongs to the aldehyde dehydrogenase family
ISN36_03640	COG1879	ABC-type sugar transport system periplasmic component
ISN36_03645	COG1129	ABC transporter
ISN36_03650	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN36_03655	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN36_03665	COG1082	Xylose isomerase domain protein TIM barrel
ISN36_03670	COG0625	glutathione transferase activity
ISN36_03680	COG0475	glutathione-regulated potassium exporter activity
ISN36_03705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN36_03710	COG2070	2-Nitropropane dioxygenase
ISN36_03725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN36_03730	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN36_03735	COG0335	large ribosomal subunit rRNA binding
ISN36_03740	COG0534	Mate efflux family protein
ISN36_03750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN36_03770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN36_03785	COG2855	membrane
ISN36_03800	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN36_03800	COG1024	Enoyl-CoA hydratase
ISN36_03815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN36_03820	COG0481	GTPase activity
ISN36_03825	COG0681	Belongs to the peptidase S26 family
ISN36_03840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN36_03850	COG0745	RESPONSE REGULATOR receiver
ISN36_03860	COG2954	triphosphatase activity
ISN36_03870	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN36_03875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN36_03880	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN36_03885	COG1278	Cold shock
ISN36_03890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN36_03900	COG1201	RNA secondary structure unwinding
ISN36_03905	COG1793	dna ligase
ISN36_03905	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN36_03910	COG1793	dna ligase
ISN36_03910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN36_03940	COG0443	Heat shock 70 kDa protein
ISN36_03950	COG0183	Belongs to the thiolase family
ISN36_03980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN36_03980	COG1703	isobutyryl-CoA mutase activity
ISN36_03980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN36_04050	COG2186	Transcriptional regulator
ISN36_04060	COG0784	Response regulator, receiver
ISN36_04060	COG2205	protein histidine kinase activity
ISN36_04060	COG2198	Histidine kinase
ISN36_04085	COG1451	nucleotide metabolic process
ISN36_04095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN36_04130	COG1077	Cell shape determining protein MreB Mrl
ISN36_04135	COG1047	Peptidyl-prolyl cis-trans
ISN36_04140	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN36_04145	COG1902	pentaerythritol trinitrate reductase activity
ISN36_04155	COG2814	Major facilitator Superfamily
ISN36_04185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN36_04185	COG0392	lysyltransferase activity
ISN36_04195	COG0251	oxidation-reduction process
ISN36_04215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN36_04240	COG1595	DNA-templated transcription, initiation
ISN36_04255	COG2878	Part of a membrane complex involved in electron transport
ISN36_04275	COG0346	lactoylglutathione lyase activity
ISN36_04285	COG0833	amino acid
ISN36_04290	COG2040	homocysteine
ISN36_04300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN36_04320	COG3118	belongs to the thioredoxin family
ISN36_04330	COG0495	leucyl-tRNA aminoacylation
ISN36_04345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN36_04360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN36_04375	COG2968	Membrane
ISN36_04395	COG0312	modulator of DNA gyrase
ISN36_04405	COG0312	modulator of DNA gyrase
ISN36_04495	COG0631	protein serine/threonine phosphatase activity
ISN36_04500	COG0515	serine threonine protein kinase
ISN36_04500	COG2815	serine threonine protein kinase
ISN36_04525	COG1858	cytochrome C peroxidase
ISN36_04535	COG0142	geranyltranstransferase activity
ISN36_04540	COG1722	exodeoxyribonuclease VII activity
ISN36_04545	COG0037	tRNA processing
ISN36_04555	COG1785	Belongs to the alkaline phosphatase family
ISN36_04560	COG1301	dicarboxylic acid transport
ISN36_04570	COG1607	acyl-coa hydrolase
ISN36_04585	COG0791	NLP P60 protein
ISN36_04590	COG0791	NLP P60 protein
ISN36_04595	COG1047	Peptidyl-prolyl cis-trans
ISN36_04600	COG2311	Membrane
ISN36_04605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN36_04655	COG3590	peptidase
ISN36_04670	COG0457	Tetratricopeptide repeat
ISN36_04675	COG4771	TonB-dependent receptor
ISN36_04680	COG4771	TonB-dependent receptor
ISN36_04690	COG0489	protein tyrosine kinase activity
ISN36_04695	COG0717	Belongs to the dCTP deaminase family
ISN36_04700	COG1714	RDD family
ISN36_04720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN36_04735	COG0494	nUDIX hydrolase
ISN36_04740	COG0433	COG0433 Predicted ATPase
ISN36_04745	COG0741	lytic transglycosylase activity
ISN36_04750	COG0688	phosphatidylethanolamine metabolic process
ISN36_04760	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN36_04775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISN36_04820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN36_04845	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_04865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN36_04875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN36_04880	COG0649	NAD binding
ISN36_04885	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN36_04890	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN36_04915	COG0713	ATP synthesis coupled electron transport
ISN36_04930	COG1007	ATP synthesis coupled electron transport
ISN36_04945	COG0195	Participates in both transcription termination and antitermination
ISN36_04970	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN36_04975	COG5001	Diguanylate cyclase
ISN36_04975	COG3300	MHYT domain
ISN36_04995	COG0840	transmembrane signaling receptor activity
ISN36_05000	COG0840	transmembrane signaling receptor activity
ISN36_05005	COG0835	chemotaxis
ISN36_05050	COG1194	a g-specific adenine glycosylase
ISN36_05055	COG0552	protein localization to endoplasmic reticulum
ISN36_05065	COG3938	Belongs to the proline racemase family
ISN36_05070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN36_05085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN36_05095	COG0006	proline dipeptidase activity
ISN36_05110	COG0531	amino acid
ISN36_05145	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN36_05155	COG4771	TonB-dependent receptor
ISN36_05180	COG0742	ribosomal rna small subunit methyltransferase
ISN36_05195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN36_05200	COG0405	Gamma-glutamyltransferase
ISN36_05205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN36_05210	COG3291	Pkd domain containing protein
ISN36_05215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN36_05225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN36_05235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN36_05245	COG1862	Preprotein translocase
ISN36_05250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN36_05275	COG4251	negative regulation of phosphorylation
ISN36_05275	COG3706	GGDEF domain
ISN36_05275	COG2203	Gaf domain
ISN36_05275	COG5001	Diguanylate cyclase
ISN36_05280	COG1509	lysine 2,3-aminomutase activity
ISN36_05290	COG3548	integral membrane protein
ISN36_05295	COG0402	S-adenosylhomocysteine deaminase activity
ISN36_05315	COG4677	pectinesterase activity
ISN36_05325	COG4677	pectinesterase activity
ISN36_05335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN36_05405	COG2166	iron-sulfur cluster assembly
ISN36_05420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN36_05425	COG0137	argininosuccinate synthase activity
ISN36_05430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN36_05435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN36_05445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN36_05450	COG0165	Argininosuccinate lyase
ISN36_05470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN36_05475	COG2801	Transposase and inactivated derivatives
ISN36_05490	COG1070	Carbohydrate kinase
ISN36_05500	COG0477	Major facilitator Superfamily
ISN36_05505	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN36_05525	COG0617	tRNA 3'-terminal CCA addition
ISN36_05535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN36_05550	COG0166	Belongs to the GPI family
ISN36_05650	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN36_05665	COG0671	phosphoesterase, PA-phosphatase related
ISN36_05690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN36_05695	COG0167	dihydroorotate dehydrogenase activity
ISN36_05710	COG1012	belongs to the aldehyde dehydrogenase family
ISN36_05725	COG0527	aspartate kinase activity
ISN36_05725	COG0460	homoserine dehydrogenase
ISN36_05730	COG0083	homoserine kinase activity
ISN36_05735	COG2951	lytic endotransglycosylase activity
ISN36_05745	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN36_05755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN36_05760	COG0124	histidyl-tRNA synthetase
ISN36_05770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN36_05775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN36_05790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN36_05805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN36_05805	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN36_05820	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN36_05825	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN36_05830	COG0235	Class ii aldolase
ISN36_05835	COG0531	amino acid
ISN36_05840	COG0531	amino acid
ISN36_05855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN36_05860	COG0277	FAD linked oxidase domain protein
ISN36_05880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN36_05895	COG1024	Enoyl-CoA hydratase
ISN36_05925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN36_05935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN36_05940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN36_05990	COG0438	transferase activity, transferring glycosyl groups
ISN36_05995	COG0438	transferase activity, transferring glycosyl groups
ISN36_06005	COG0438	transferase activity, transferring glycosyl groups
ISN36_06025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN36_06035	COG1960	acyl-CoA dehydrogenase activity
ISN36_06080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN36_06085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN36_06085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN36_06090	COG0802	atpase or kinase
ISN36_06095	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN36_06100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN36_06120	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_06140	COG2081	HI0933 family
ISN36_06145	COG4681	YaeQ
ISN36_06150	COG0564	pseudouridine synthase activity
ISN36_06160	COG0625	glutathione transferase activity
ISN36_06165	COG0657	acetylesterase activity
ISN36_06170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN36_06195	COG0513	Belongs to the DEAD box helicase family
ISN36_06200	COG0488	(ABC) transporter
ISN36_06215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN36_06225	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN36_06265	COG1846	Transcriptional regulator
ISN36_06280	COG0386	Belongs to the glutathione peroxidase family
ISN36_06305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISN36_06355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN36_06360	COG0084	hydrolase, TatD family'
ISN36_06375	COG1960	acyl-CoA dehydrogenase activity
ISN36_06385	COG0305	Participates in initiation and elongation during chromosome replication
ISN36_06390	COG0415	Belongs to the DNA photolyase family
ISN36_06405	COG0583	DNA-binding transcription factor activity
ISN36_06420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN36_06455	COG1404	Belongs to the peptidase S8 family
ISN36_06460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN36_06465	COG2867	negative regulation of translational initiation
ISN36_06475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN36_06480	COG0735	belongs to the Fur family
ISN36_06485	COG0497	DNA recombination
ISN36_06490	COG1420	regulation of RNA biosynthetic process
ISN36_06495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN36_06500	COG0443	Heat shock 70 kDa protein
ISN36_06505	COG0484	heat shock protein binding
ISN36_06510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN36_06515	COG0287	Prephenate dehydrogenase
ISN36_06515	COG1605	Chorismate mutase
ISN36_06525	COG1132	(ABC) transporter
ISN36_06575	COG2850	peptidyl-arginine hydroxylation
ISN36_06580	COG2885	chlorophyll binding
ISN36_06625	COG1131	(ABC) transporter
ISN36_06630	COG1725	Transcriptional regulator
ISN36_06640	COG0386	Belongs to the glutathione peroxidase family
ISN36_06655	COG2900	Belongs to the SlyX family
ISN36_06675	COG0646	methionine synthase
ISN36_06675	COG1410	methionine synthase
ISN36_06680	COG0646	methionine synthase
ISN36_06680	COG1410	methionine synthase
ISN36_06685	COG2226	methyltransferase
ISN36_06690	COG1960	acyl-CoA dehydrogenase activity
ISN36_06765	COG0556	nucleotide-excision repair
ISN36_06780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN36_06785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN36_06795	COG2902	Dehydrogenase
ISN36_06820	COG1294	oxidase, subunit
ISN36_06830	COG4988	ABC transporter
ISN36_06835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN36_06840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN36_06885	COG4133	protoheme IX ABC transporter activity
ISN36_06890	COG0436	Aminotransferase
ISN36_06930	COG1187	pseudouridine synthase activity
ISN36_06935	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN36_06940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN36_06945	COG2350	Protein conserved in bacteria
ISN36_06980	COG0395	ABC-type sugar transport system, permease component
ISN36_06995	COG0129	dihydroxy-acid dehydratase activity
ISN36_07010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN36_07030	COG2009	succinate dehydrogenase
ISN36_07035	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN36_07045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISN36_07050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN36_07060	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN36_07080	COG0811	peptide transport
ISN36_07090	COG1132	(ABC) transporter
ISN36_07095	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN36_07105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN36_07120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN36_07155	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN36_07160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN36_07170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN36_07210	COG1132	(ABC) transporter
ISN36_07235	COG1530	ribonuclease E activity
ISN36_07250	COG0428	transporter
ISN36_07265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN36_07265	COG0316	Belongs to the HesB IscA family
ISN36_07285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN36_07305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN36_07310	COG2957	Belongs to the agmatine deiminase family
ISN36_07320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN36_07325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN36_07330	COG0539	negative regulation of cytoplasmic translation
ISN36_07335	COG0776	regulation of translation
ISN36_07345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN36_07350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN36_07360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN36_07365	COG0183	Belongs to the thiolase family
ISN36_07370	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN36_07370	COG1024	Enoyl-CoA hydratase
ISN36_07385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN36_07395	COG1426	Protein conserved in bacteria
ISN36_07405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN36_07415	COG0746	molybdenum cofactor guanylyltransferase activity
ISN36_07425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN36_07430	COG0475	glutathione-regulated potassium exporter activity
ISN36_07430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN36_07450	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN36_07460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN36_07460	COG0519	Catalyzes the synthesis of GMP from XMP
ISN36_07465	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN36_07470	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN36_07480	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN36_07495	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN36_07500	COG0668	transmembrane transport
ISN36_07510	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN36_07525	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_07530	COG1183	phosphatidylcholine synthase activity
ISN36_07540	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN36_07560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN36_07560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN36_07570	COG0784	Response regulator, receiver
ISN36_07570	COG4191	Histidine kinase
ISN36_07575	COG2183	response to ionizing radiation
ISN36_07580	COG0784	Response regulator, receiver
ISN36_07580	COG2205	protein histidine kinase activity
ISN36_07615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN36_07645	COG1649	PFAM Uncharacterised BCR, COG1649
ISN36_07650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN36_07655	COG1304	FMN binding
ISN36_07665	COG0346	lactoylglutathione lyase activity
ISN36_07705	COG1024	Enoyl-CoA hydratase
ISN36_07710	COG1024	Enoyl-CoA hydratase
ISN36_07720	COG1024	Enoyl-CoA hydratase
ISN36_07735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN36_07740	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN36_07785	COG1074	ATP-dependent DNA helicase activity
ISN36_07875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN36_07880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN36_07890	COG0505	Belongs to the CarA family
ISN36_07900	COG2258	MOSC domain
ISN36_07905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN36_07920	COG0438	transferase activity, transferring glycosyl groups
ISN36_07925	COG0438	transferase activity, transferring glycosyl groups
ISN36_07945	COG4106	trans-aconitate 2-methyltransferase activity
ISN36_07965	COG2244	polysaccharide biosynthetic process
ISN36_07995	COG3038	cytochrome b561
ISN36_08015	COG1595	DNA-templated transcription, initiation
ISN36_08070	COG0038	chloride channel
ISN36_08075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN36_08095	COG1674	ftsk spoiiie
ISN36_08100	COG0492	ferredoxin-NADP+ reductase activity
ISN36_08110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISN36_08120	COG0542	response to heat
ISN36_08140	COG0482	sulfurtransferase activity
ISN36_08145	COG2915	High frequency lysogenization protein hflD homolog
ISN36_08205	COG0784	Response regulator, receiver
ISN36_08205	COG0835	chemotaxis
ISN36_08215	COG1558	bacterial-type flagellum-dependent cell motility
ISN36_08225	COG1749	Flagellar hook protein flgE
ISN36_08240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN36_08255	COG4786	Flagellar basal body rod
ISN36_08255	COG4786	Flagellar basal body rod
ISN36_08255	COG1256	bacterial-type flagellum assembly
ISN36_08255	COG1256	bacterial-type flagellum assembly
ISN36_08265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN36_08270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN36_08290	COG2197	response regulator
ISN36_08300	COG2201	protein-glutamate methylesterase activity
ISN36_08320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN36_08330	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_08365	COG1677	Flagellar hook-basal body complex protein FliE
ISN36_08415	COG3190	flagellar
ISN36_08425	COG1987	bacterial-type flagellum assembly
ISN36_08430	COG1684	flagellar biosynthetic protein fliR
ISN36_08475	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN36_08480	COG2198	Histidine kinase
ISN36_08480	COG0784	Response regulator, receiver
ISN36_08480	COG0643	Histidine kinase
ISN36_08485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN36_08495	COG1192	Involved in chromosome partitioning
ISN36_08500	COG0835	chemotaxis
ISN36_08510	COG0745	RESPONSE REGULATOR receiver
ISN36_08520	COG0840	transmembrane signaling receptor activity
ISN36_08525	COG0840	transmembrane signaling receptor activity
ISN36_08530	COG0840	transmembrane signaling receptor activity
ISN36_08535	COG0840	transmembrane signaling receptor activity
ISN36_08545	COG0840	transmembrane signaling receptor activity
ISN36_08555	COG0840	transmembrane signaling receptor activity
ISN36_08560	COG0840	transmembrane signaling receptor activity
ISN36_08565	COG0840	transmembrane signaling receptor activity
ISN36_08575	COG0840	transmembrane signaling receptor activity
ISN36_08585	COG0835	chemotaxis
ISN36_08595	COG0840	transmembrane signaling receptor activity
ISN36_08605	COG0840	transmembrane signaling receptor activity
ISN36_08665	COG0318	PFAM AMP-dependent synthetase and ligase
ISN36_08670	COG1024	Enoyl-CoA hydratase
ISN36_08675	COG2205	protein histidine kinase activity
ISN36_08675	COG2198	Histidine kinase
ISN36_08675	COG0784	Response regulator, receiver
ISN36_08710	COG0800	Aldolase
ISN36_08725	COG3734	2-keto-3-deoxy-galactonokinase
ISN36_08730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN36_08740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN36_08750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN36_08755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN36_08795	COG0352	thiamine-phosphate diphosphorylase activity
ISN36_08795	COG0351	phosphomethylpyrimidine kinase
ISN36_08815	COG0583	DNA-binding transcription factor activity
ISN36_08820	COG1741	Belongs to the pirin family
ISN36_08845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISN36_08855	COG2137	regulation of response to DNA damage stimulus
ISN36_08860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN36_08865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN36_08870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN36_08875	COG1546	Belongs to the CinA family
ISN36_08880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN36_08890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN36_08895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN36_08900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN36_08905	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN36_08910	COG1534	Rna-binding protein
ISN36_08925	COG1238	metal cluster binding
ISN36_08935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN36_08950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN36_08955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN36_08975	COG0504	CTP synthase activity
ISN36_08995	COG0306	phosphate transporter
ISN36_09005	COG1253	flavin adenine dinucleotide binding
ISN36_09020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN36_09055	COG0069	glutamate synthase activity
ISN36_09060	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN36_09070	COG1609	Transcriptional regulator
ISN36_09075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN36_09075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN36_09080	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN36_09085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN36_09085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN36_09120	COG1136	(ABC) transporter
ISN36_09120	COG0577	efflux transmembrane transporter activity
ISN36_09205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISN36_09240	COG0583	DNA-binding transcription factor activity
ISN36_09265	COG0077	Prephenate dehydratase
ISN36_09265	COG1605	Chorismate mutase
ISN36_09270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN36_09275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN36_09315	COG4221	oxidoreductase activity
ISN36_09330	COG1228	amidohydrolase
ISN36_09345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN36_09385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN36_09395	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN36_09400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN36_09405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN36_09440	COG0316	Belongs to the HesB IscA family
ISN36_09465	COG2197	response regulator
ISN36_09510	COG0288	reversible hydration of carbon dioxide
ISN36_09525	COG3844	kynureninase activity
ISN36_09535	COG2925	Exonuclease
ISN36_09575	COG2801	Transposase and inactivated derivatives
ISN36_09650	COG3275	phosphorelay sensor kinase activity
ISN36_09655	COG1611	Belongs to the LOG family
ISN36_09665	COG2095	MarC family integral membrane protein
ISN36_09670	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_09675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN36_09715	COG2969	positive regulation of protein catabolic process
ISN36_09720	COG0625	glutathione transferase activity
ISN36_09725	COG2857	Cytochrome c1
ISN36_09735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN36_09740	COG0723	plastoquinol--plastocyanin reductase activity
ISN36_09745	COG0741	lytic transglycosylase activity
ISN36_09760	COG1702	phosphate starvation-inducible protein PhoH
ISN36_09775	COG4535	Mg2 and Co2 transporter CorC
ISN36_09790	COG1012	belongs to the aldehyde dehydrogenase family
ISN36_09795	COG1177	transmembrane transport
ISN36_09800	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN36_09805	COG3842	ATPase activity
ISN36_09845	COG0174	glutamine synthetase
ISN36_09850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN36_09855	COG0174	glutamine synthetase
ISN36_09860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN36_09870	COG0477	Major facilitator Superfamily
ISN36_09885	COG0243	molybdopterin cofactor binding
ISN36_09895	COG2223	nitrite transmembrane transporter activity
ISN36_09915	COG1012	belongs to the aldehyde dehydrogenase family
ISN36_09920	COG1917	Cupin 2, conserved barrel domain protein
ISN36_09920	COG1396	sequence-specific DNA binding
ISN36_09925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN36_09930	COG0686	Belongs to the AlaDH PNT family
ISN36_09950	COG2733	membrane
ISN36_09955	COG5002	protein histidine kinase activity
ISN36_09955	COG0784	Response regulator, receiver
ISN36_09955	COG2205	protein histidine kinase activity
ISN36_10015	COG1024	Enoyl-CoA hydratase
ISN36_10025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN36_10030	COG0659	secondary active sulfate transmembrane transporter activity
ISN36_10050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN36_10055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN36_10065	COG0581	inorganic phosphate transmembrane transporter activity
ISN36_10075	COG0704	Plays a role in the regulation of phosphate uptake
ISN36_10100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN36_10120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN36_10130	COG0557	exoribonuclease II activity
ISN36_10165	COG2814	Major facilitator Superfamily
ISN36_10170	COG1566	PFAM secretion protein HlyD family protein
ISN36_10210	COG0367	asparagine synthase
ISN36_10220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN36_10230	COG1393	Belongs to the ArsC family
ISN36_10245	COG0024	Methionine aminopeptidase
ISN36_10285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN36_10295	COG0528	UMP kinase activity
ISN36_10305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN36_10310	COG0575	Belongs to the CDS family
ISN36_10315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN36_10320	COG0750	zinc metalloprotease
ISN36_10330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN36_10340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN36_10345	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN36_10370	COG1981	membrane
ISN36_10475	COG1132	(ABC) transporter
ISN36_10495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN36_10520	COG1187	pseudouridine synthase activity
ISN36_10635	COG2080	2 iron, 2 sulfur cluster binding
ISN36_10640	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN36_10645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN36_10685	COG0735	belongs to the Fur family
ISN36_10720	COG2205	protein histidine kinase activity
ISN36_10730	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN36_10750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN36_10760	COG0643	Histidine kinase
ISN36_10760	COG2198	Histidine kinase
ISN36_10765	COG0840	transmembrane signaling receptor activity
ISN36_10770	COG0840	transmembrane signaling receptor activity
ISN36_10775	COG0840	transmembrane signaling receptor activity
ISN36_10780	COG0835	chemotaxis
ISN36_10805	COG2801	Transposase and inactivated derivatives
ISN36_10815	COG2211	Major facilitator Superfamily
ISN36_10850	COG1966	Carbon starvation protein
ISN36_10855	COG2879	small protein
ISN36_10860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN36_10880	COG1506	peptidase
ISN36_10880	COG0823	Involved in the tonB-independent uptake of proteins
ISN36_10885	COG1297	OPT oligopeptide transporter protein
ISN36_10890	COG3104	oligopeptide transport
ISN36_10910	COG0629	single-stranded DNA binding
ISN36_10915	COG0142	geranyltranstransferase activity
ISN36_10940	COG0527	aspartate kinase activity
ISN36_10945	COG0384	phenazine biosynthesis protein PhzF
ISN36_10955	COG1764	response to oxidative stress
ISN36_10970	COG0739	heme binding
ISN36_10985	COG0693	protein deglycase activity
ISN36_11000	COG0719	Fe-S assembly protein
ISN36_11005	COG0396	ATPase activity
ISN36_11010	COG0719	Fe-S assembly protein
ISN36_11015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN36_11025	COG2146	nitrite reductase [NAD(P)H] activity
ISN36_11030	COG4774	siderophore transport
ISN36_11055	COG1477	protein flavinylation
ISN36_11060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN36_11080	COG1555	photosystem II stabilization
ISN36_11095	COG3178	'Phosphotransferase
ISN36_11100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN36_11110	COG0628	permease
ISN36_11135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN36_11180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN36_11195	COG1137	ATPase activity
ISN36_11210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN36_11220	COG1660	Displays ATPase and GTPase activities
ISN36_11230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN36_11235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN36_11240	COG2239	Acts as a magnesium transporter
ISN36_11260	COG1113	amino acid transport
ISN36_11270	COG0840	transmembrane signaling receptor activity
ISN36_11295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN36_11310	COG0519	Catalyzes the synthesis of GMP from XMP
ISN36_11325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISN36_11365	COG0259	pyridoxamine-phosphate oxidase activity
ISN36_11370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN36_11390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN36_11400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN36_11405	COG2814	Major facilitator Superfamily
ISN36_11425	COG3038	cytochrome b561
ISN36_11440	COG1760	l-serine dehydratase
ISN36_11450	COG2267	carboxylic ester hydrolase activity
ISN36_11455	COG0460	homoserine dehydrogenase
ISN36_11455	COG0527	aspartate kinase activity
ISN36_11460	COG0626	cystathionine gamma-synthase activity
ISN36_11465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN36_11475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN36_11480	COG1272	protein, Hemolysin III
ISN36_11485	COG2982	Protein involved in outer membrane biogenesis
ISN36_11490	COG0517	IMP dehydrogenase activity
ISN36_11495	COG0463	Glycosyl transferase, family 2
ISN36_11500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN36_11505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN36_11555	COG1304	FMN binding
ISN36_11565	COG1657	PFAM Prenyltransferase squalene oxidase
ISN36_11570	COG0142	geranyltranstransferase activity
ISN36_11575	COG2124	cytochrome p450
ISN36_11580	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_11585	COG1141	Ferredoxin
ISN36_11590	COG2124	cytochrome p450
ISN36_11595	COG2124	cytochrome p450
ISN36_11665	COG0330	HflC and HflK could
ISN36_11675	COG1742	UPF0060 membrane protein
ISN36_11680	COG3956	TIGRFAM MazG family protein
ISN36_11685	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN36_11690	COG0494	nUDIX hydrolase
ISN36_11700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN36_11710	COG0837	glucose binding
ISN36_11725	COG3858	chitin binding
ISN36_11725	COG1388	LysM domain
ISN36_11730	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN36_11740	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN36_11760	COG3537	Alpha-1,2-mannosidase
ISN36_11930	COG3179	chitinase
ISN36_12020	COG4682	membrane
ISN36_12065	COG3209	COG3209 Rhs family protein
ISN36_12075	COG3209	COG3209 Rhs family protein
ISN36_12165	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN36_12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN36_12190	COG1295	ribonuclease BN
ISN36_12210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISN36_12220	COG1404	Belongs to the peptidase S8 family
ISN36_12225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN36_12285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN36_12285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN36_12340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN36_12340	COG4651	solute:proton antiporter activity
ISN36_12350	COG4772	TonB-dependent receptor
ISN36_12360	COG4264	IucA IucC family
ISN36_12365	COG2814	Major facilitator Superfamily
ISN36_12370	COG4264	IucA IucC family
ISN36_12375	COG0019	diaminopimelate decarboxylase activity
ISN36_12400	COG0542	response to heat
ISN36_12450	COG3387	PFAM Glycoside hydrolase 15-related
ISN36_12465	COG4993	Dehydrogenase
ISN36_12485	COG0564	pseudouridine synthase activity
ISN36_12490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN36_12500	COG1125	glycine betaine transport
ISN36_12505	COG1174	glycine betaine transport
ISN36_12525	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN36_12535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN36_12535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN36_12605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN36_12620	COG0745	RESPONSE REGULATOR receiver
ISN36_12630	COG0189	ligase activity
ISN36_12640	COG3511	phospholipase C
ISN36_12665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN36_12680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN36_12690	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN36_12695	COG0174	glutamine synthetase
ISN36_12720	COG2022	thiamine diphosphate biosynthetic process
ISN36_12730	COG0471	metal ion transport
ISN36_12730	COG3273	potassium ion transport
ISN36_12745	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN36_12760	COG1609	Transcriptional regulator
ISN36_12775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN36_12790	COG1115	amino acid carrier protein
ISN36_12810	COG0840	transmembrane signaling receptor activity
ISN36_12815	COG2895	sulfate adenylyltransferase (ATP) activity
ISN36_12815	COG0529	Catalyzes the synthesis of activated sulfate
ISN36_12825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN36_12830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN36_12835	COG0175	sulfate reduction
ISN36_12865	COG1393	Belongs to the ArsC family
ISN36_12870	COG2198	Histidine kinase
ISN36_12870	COG2205	protein histidine kinase activity
ISN36_12870	COG0784	Response regulator, receiver
ISN36_12885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN36_12885	COG1648	precorrin-2 dehydrogenase activity
ISN36_12900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN36_12940	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN36_12945	COG3588	fructose-bisphosphate aldolase
ISN36_12950	COG0469	pyruvate kinase activity
ISN36_12995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN36_13000	COG3047	cAMP biosynthetic process
ISN36_13020	COG0640	Transcriptional regulator
ISN36_13030	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN36_13035	COG4149	molybdate abc transporter
ISN36_13040	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN36_13065	COG1376	ErfK ybiS ycfS ynhG family protein
ISN36_13070	COG0739	heme binding
ISN36_13095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN36_13100	COG1301	dicarboxylic acid transport
ISN36_13130	COG0714	Associated with various cellular activities
ISN36_13160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN36_13180	COG0006	proline dipeptidase activity
ISN36_13185	COG3079	Belongs to the UPF0149 family
ISN36_13210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN36_13220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN36_13235	COG1773	rubredoxin
ISN36_13250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN36_13290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN36_13300	COG1940	carbohydrate kinase activity
ISN36_13315	COG0671	phosphoesterase, PA-phosphatase related
ISN36_13325	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN36_13345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN36_13355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN36_13375	COG0840	transmembrane signaling receptor activity
ISN36_13380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN36_13400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN36_13410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN36_13420	COG0066	3-isopropylmalate dehydratase activity
ISN36_13425	COG0473	3-isopropylmalate dehydrogenase activity
ISN36_13430	COG3706	GGDEF domain
ISN36_13440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN36_13445	COG1538	Outer membrane efflux protein
ISN36_13450	COG1519	Transferase
ISN36_13455	COG1560	Kdo2-lipid A biosynthetic process
ISN36_13530	COG0280	phosphate acetyltransferase
ISN36_13530	COG0281	malic enzyme
ISN36_13535	COG1301	dicarboxylic acid transport
ISN36_13545	COG4191	Histidine kinase
ISN36_13565	COG0642	Histidine kinase
ISN36_13580	COG2851	Citrate transporter
ISN36_13585	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_13595	COG2211	Major facilitator Superfamily
ISN36_13620	COG1162	GTPase activity
ISN36_13625	COG0436	Aminotransferase
ISN36_13650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN36_13670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN36_13705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN36_13715	COG3791	Glutathione-dependent formaldehyde-activating
ISN36_13720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN36_13735	COG2205	protein histidine kinase activity
ISN36_13815	COG0617	tRNA 3'-terminal CCA addition
ISN36_13820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN36_13825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN36_13830	COG1609	Transcriptional regulator
ISN36_13835	COG0738	Major facilitator superfamily
ISN36_13840	COG2188	Transcriptional regulator
ISN36_13855	COG3250	beta-galactosidase activity
ISN36_13885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN36_13895	COG4191	Histidine kinase
ISN36_13900	COG0784	Response regulator, receiver
ISN36_13905	COG2205	protein histidine kinase activity
ISN36_13905	COG2202	Pas domain
ISN36_13915	COG2823	Periplasmic or secreted lipoprotein
ISN36_13920	COG0673	inositol 2-dehydrogenase activity
ISN36_13925	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN36_13935	COG1090	epimerase
ISN36_13950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN36_13990	COG2226	methyltransferase
ISN36_14015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN36_14025	COG0494	nUDIX hydrolase
ISN36_14040	COG0739	heme binding
ISN36_14050	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN36_14055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN36_14065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN36_14070	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN36_14080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISN36_14095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN36_14110	COG3116	cell division
ISN36_14115	COG0275	rRNA processing
ISN36_14120	COG2001	Belongs to the MraZ family
ISN36_14155	COG0792	nuclease activity
ISN36_14165	COG0277	FAD linked oxidase domain protein
ISN36_14170	COG0745	RESPONSE REGULATOR receiver
ISN36_14175	COG2205	protein histidine kinase activity
ISN36_14185	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN36_14190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN36_14215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN36_14220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN36_14225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN36_14240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN36_14240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN36_14250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN36_14280	COG0477	Major facilitator Superfamily
ISN36_14285	COG0488	(ABC) transporter
ISN36_14290	COG0242	peptide deformylase activity
ISN36_14320	COG1215	transferase activity, transferring glycosyl groups
ISN36_14330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN36_14385	COG2188	Transcriptional regulator
ISN36_14395	COG1450	Type ii and iii secretion system protein
ISN36_14410	COG3166	PFAM Fimbrial assembly family protein
ISN36_14415	COG3156	type II secretion system protein K
ISN36_14420	COG4795	General secretion pathway protein
ISN36_14425	COG2165	general secretion pathway protein
ISN36_14430	COG4970	Tfp pilus assembly protein FimT
ISN36_14435	COG2165	general secretion pathway protein
ISN36_14440	COG1459	type II secretion system
ISN36_14445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN36_14450	COG1404	Belongs to the peptidase S8 family
ISN36_14455	COG5295	Hep Hag repeat protein
ISN36_14465	COG0840	transmembrane signaling receptor activity
ISN36_14470	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN36_14470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN36_14475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN36_14480	COG4974	Belongs to the 'phage' integrase family
ISN36_14505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN36_14510	COG2927	DNA polymerase III (CHI subunit)
ISN36_14545	COG1183	phosphatidylcholine synthase activity
ISN36_14555	COG0442	prolyl-tRNA aminoacylation
ISN36_14570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN36_14575	COG1127	ABC transporter
ISN36_14580	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN36_14580	COG3218	ABC-type transport auxiliary lipoprotein component
ISN36_14610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN36_14615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN36_14620	COG0662	Cupin 2, conserved barrel domain protein
ISN36_14620	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN36_14645	COG2086	electron transfer activity
ISN36_14660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN36_14660	COG0546	phosphoglycolate phosphatase activity
ISN36_14665	COG0277	FAD linked oxidase domain protein
ISN36_14670	COG0300	oxidoreductase activity
ISN36_14695	COG0493	'glutamate synthase
ISN36_14735	COG0438	transferase activity, transferring glycosyl groups
ISN36_14735	COG1216	Glycosyl transferase, family 2
ISN36_14740	COG0438	transferase activity, transferring glycosyl groups
ISN36_14740	COG1216	Glycosyl transferase, family 2
ISN36_14745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN36_14760	COG0626	cystathionine gamma-synthase activity
ISN36_14790	COG0625	glutathione transferase activity
ISN36_14800	COG0513	Belongs to the DEAD box helicase family
ISN36_14805	COG0720	synthase
ISN36_14815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN36_14820	COG1956	GAF domain-containing protein
ISN36_14830	COG4206	TonB-dependent receptor
ISN36_14835	COG0546	phosphoglycolate phosphatase activity
ISN36_14840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISN36_14860	COG0339	signal peptide processing
ISN36_14875	COG2217	Heavy metal translocating P-type atpase
ISN36_14890	COG2132	Multicopper oxidase
ISN36_14905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN36_14915	COG1136	(ABC) transporter
ISN36_14920	COG0577	efflux transmembrane transporter activity
ISN36_14920	COG1136	(ABC) transporter
ISN36_14925	COG1136	(ABC) transporter
ISN36_14925	COG0577	efflux transmembrane transporter activity
ISN36_14930	COG0577	efflux transmembrane transporter activity
ISN36_14930	COG1136	(ABC) transporter
ISN36_14950	COG4191	Histidine kinase
ISN36_14960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN36_14975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN36_14990	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN36_15000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN36_15010	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN36_15025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN36_15030	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN36_15065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN36_15070	COG0697	spore germination
ISN36_15075	COG1666	GTP binding
ISN36_15085	COG1187	pseudouridine synthase activity
ISN36_15110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN36_15110	COG2205	protein histidine kinase activity
ISN36_15135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN36_15210	COG0842	Transport permease protein
ISN36_15215	COG1131	(ABC) transporter
ISN36_15220	COG0025	NhaP-type Na H and K H
ISN36_15230	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN36_15235	COG1573	uracil-dna glycosylase
ISN36_15245	COG3384	dioxygenase
ISN36_15270	COG0667	Aldo Keto reductase
ISN36_15280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN36_15285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN36_15305	COG3706	GGDEF domain
ISN36_15310	COG2146	nitrite reductase [NAD(P)H] activity
ISN36_15315	COG5001	Diguanylate cyclase
ISN36_15345	COG4106	trans-aconitate 2-methyltransferase activity
ISN36_15355	COG2076	Multidrug Resistance protein
ISN36_15365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN36_15390	COG3279	Response regulator of the LytR AlgR family
ISN36_15395	COG3275	phosphorelay sensor kinase activity
ISN36_15420	COG0531	amino acid
ISN36_15430	COG5297	Belongs to the glycosyl hydrolase family 6
ISN36_15430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN36_15445	COG0741	lytic transglycosylase activity
ISN36_15460	COG2207	Transcriptional regulator
ISN36_15470	COG0598	Magnesium transport protein CorA
ISN36_15475	COG1113	amino acid transport
ISN36_15480	COG0697	spore germination
ISN36_15505	COG5520	Belongs to the glycosyl hydrolase 30 family
ISN36_15560	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN36_15600	COG0840	transmembrane signaling receptor activity
ISN36_15615	COG2353	YceI-like domain
ISN36_15645	COG0584	glycerophosphoryl diester phosphodiesterase
ISN36_15660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN36_15680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN36_15685	COG0459	protein refolding
ISN36_15700	COG1324	tolerance protein
ISN36_15710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN36_15720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN36_15725	COG0511	ligase activity, forming carbon-carbon bonds
ISN36_15730	COG0439	Biotin carboxylase
ISN36_15745	COG2264	protein methyltransferase activity
ISN36_15765	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN36_15770	COG4589	Belongs to the CDS family
ISN36_15790	COG2267	carboxylic ester hydrolase activity
ISN36_15795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN36_15800	COG0138	bifunctional purine biosynthesis protein purh
ISN36_15805	COG0151	Belongs to the GarS family
ISN36_15810	COG1289	transmembrane transporter activity
ISN36_15815	COG2814	Major facilitator Superfamily
ISN36_15855	COG2816	NAD+ diphosphatase activity
ISN36_15895	COG2906	2 iron, 2 sulfur cluster binding
ISN36_15925	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN36_15940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN36_15945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN36_15950	COG0730	response to heat
ISN36_15960	COG0134	indole-3-glycerol-phosphate synthase activity
ISN36_15965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN36_15985	COG1597	lipid kinase activity
ISN36_16000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN36_16015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN36_16020	COG2111	Na H antiporter
ISN36_16020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN36_16025	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN36_16030	COG0651	ATP synthesis coupled electron transport
ISN36_16035	COG1863	multisubunit Na H antiporter MnhE subunit
ISN36_16040	COG2212	antiporter activity
ISN36_16045	COG1320	monovalent cation:proton antiporter activity
ISN36_16050	COG0530	calcium, potassium:sodium antiporter activity
ISN36_16065	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN36_16085	COG3104	oligopeptide transport
ISN36_16090	COG3483	tryptophan 2,3-dioxygenase activity
ISN36_16120	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN36_16145	COG0513	Belongs to the DEAD box helicase family
ISN36_16160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN36_16170	COG2354	Protein conserved in bacteria
ISN36_16195	COG3264	Mechanosensitive ion channel
ISN36_16195	COG1196	nuclear chromosome segregation
ISN36_16200	COG3321	synthase
ISN36_16200	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_16200	COG0604	alcohol dehydrogenase
ISN36_16220	COG1595	DNA-templated transcription, initiation
ISN36_16235	COG1802	Transcriptional regulator
ISN36_16270	COG3052	prosthetic group binding
ISN36_16280	COG1414	Transcriptional regulator
ISN36_16285	COG0738	Major facilitator superfamily
ISN36_16290	COG3254	rhamnose metabolic process
ISN36_16295	COG4948	Mandelate Racemase Muconate Lactonizing
ISN36_16300	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN36_16305	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_16335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN36_16350	COG4807	Protein conserved in bacteria
ISN36_16370	COG4773	Receptor
ISN36_16390	COG0823	Involved in the tonB-independent uptake of proteins
ISN36_16390	COG1506	peptidase
ISN36_16445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN36_16465	COG0628	permease
ISN36_16470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN36_16475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN36_16480	COG0753	catalase activity
ISN36_16505	COG1136	(ABC) transporter
ISN36_16510	COG0577	efflux transmembrane transporter activity
ISN36_16545	COG0180	Tryptophanyl-tRNA synthetase
ISN36_16580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN36_16585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN36_16585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN36_16595	COG3228	Belongs to the MtfA family
ISN36_16640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN36_16665	COG2084	Dehydrogenase
ISN36_16670	COG1902	pentaerythritol trinitrate reductase activity
ISN36_16695	COG1404	Belongs to the peptidase S8 family
ISN36_16700	COG2814	Major facilitator Superfamily
ISN36_16705	COG0583	DNA-binding transcription factor activity
ISN36_16725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN36_16730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN36_16745	COG1764	response to oxidative stress
ISN36_16750	COG1846	Transcriptional regulator
ISN36_16755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN36_16765	COG0697	spore germination
ISN36_16775	COG0523	cobalamin synthesis protein
ISN36_16785	COG1742	UPF0060 membrane protein
ISN36_16800	COG1960	acyl-CoA dehydrogenase activity
ISN36_16805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN36_16835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN36_16840	COG3387	PFAM Glycoside hydrolase 15-related
ISN36_16845	COG0745	RESPONSE REGULATOR receiver
ISN36_16860	COG1404	Belongs to the peptidase S8 family
ISN36_16870	COG3100	YcgL domain-containing protein
ISN36_16875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN36_16885	COG0463	Glycosyl transferase, family 2
ISN36_16920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN36_16935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN36_16960	COG1294	oxidase, subunit
ISN36_16965	COG1271	oxidase subunit
ISN36_16980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN36_16985	COG0408	coproporphyrinogen oxidase activity
ISN36_16995	COG2323	membrane
ISN36_17000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN36_17000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN36_17015	COG0589	response to stress
ISN36_17035	COG0210	DNA helicase
ISN36_17085	COG0463	Glycosyl transferase, family 2
ISN36_17095	COG1475	DNA binding
ISN36_17100	COG1192	Involved in chromosome partitioning
ISN36_17105	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN36_17120	COG2091	lysine biosynthetic process via aminoadipic acid
ISN36_17145	COG0477	Major facilitator Superfamily
ISN36_17165	COG1971	Probably functions as a manganese efflux pump
ISN36_17170	COG2205	protein histidine kinase activity
ISN36_17180	COG3459	Glycosyltransferase 36 associated
ISN36_17185	COG2211	Major facilitator Superfamily
ISN36_17190	COG3265	gluconokinase activity
ISN36_17205	COG2911	Protein conserved in bacteria
ISN36_17210	COG0729	surface antigen
ISN36_17240	COG3132	Protein of unknown function, DUF480
ISN36_17300	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN36_17315	COG1609	Transcriptional regulator
ISN36_17325	COG2937	Belongs to the GPAT DAPAT family
ISN36_17350	COG2211	Major facilitator Superfamily
ISN36_17365	COG3693	PFAM glycoside hydrolase, family 10
ISN36_17385	COG3386	PFAM SMP-30 Gluconolaconase
ISN36_17405	COG0246	Mannitol dehydrogenase
ISN36_17410	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN36_17420	COG4948	Mandelate Racemase Muconate Lactonizing
ISN36_17430	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN36_17440	COG2115	Belongs to the xylose isomerase family
ISN36_17445	COG0037	tRNA processing
ISN36_17465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN36_17475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN36_17485	COG0805	protein transport
ISN36_17495	COG0519	Catalyzes the synthesis of GMP from XMP
ISN36_17495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN36_17500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN36_17520	COG0210	DNA helicase
ISN36_17525	COG1435	thymidine kinase activity
ISN36_17535	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN36_17560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN36_17575	COG1119	ATPase activity
ISN36_17590	COG0706	membrane insertase activity
ISN36_17595	COG0594	ribonuclease P activity
ISN36_17615	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN36_17620	COG0187	DNA topoisomerase II activity
ISN36_17625	COG1266	CAAX protease self-immunity
ISN36_17630	COG0501	Belongs to the peptidase M48B family
ISN36_17670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN36_17685	COG1280	lysine exporter protein (LysE YggA)
ISN36_17700	COG4772	TonB-dependent receptor
ISN36_17710	COG3284	Transcriptional regulator
ISN36_17715	COG1012	belongs to the aldehyde dehydrogenase family
ISN36_17750	COG1304	FMN binding
ISN36_17785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN36_17860	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN36_17880	COG4771	TonB-dependent receptor
ISN36_17925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN36_17940	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN36_17945	COG1609	Transcriptional regulator
ISN36_17955	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_17970	COG3186	Phenylalanine-4-hydroxylase
ISN36_17975	COG1522	sequence-specific DNA binding
ISN36_17995	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN36_18015	COG0671	phosphoesterase, PA-phosphatase related
ISN36_18030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN36_18075	COG0531	amino acid
ISN36_18080	COG4566	intracellular signal transduction
ISN36_18085	COG4191	Histidine kinase
ISN36_18105	COG1322	Protein conserved in bacteria
ISN36_18110	COG0386	Belongs to the glutathione peroxidase family
ISN36_18115	COG2853	Lipoprotein
ISN36_18130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN36_18135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN36_18140	COG1127	ABC transporter
ISN36_18145	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN36_18150	COG1074	ATP-dependent DNA helicase activity
ISN36_18155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN36_18175	COG0537	adenosine 5'-monophosphoramidase activity
ISN36_18245	COG0477	Major facilitator Superfamily
ISN36_18250	COG0302	gtp cyclohydrolase
ISN36_18275	COG0730	response to heat
ISN36_18290	COG2951	lytic endotransglycosylase activity
ISN36_18350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN36_18355	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN36_18360	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN36_18365	COG0493	'glutamate synthase
ISN36_18370	COG0067	glutamate synthase
ISN36_18370	COG0070	glutamate synthase
ISN36_18370	COG0069	glutamate synthase activity
ISN36_18415	COG1205	dead DEAH box helicase
ISN36_18415	COG1111	helicase
ISN36_18450	COG2271	Major facilitator Superfamily
ISN36_18495	COG1192	Involved in chromosome partitioning
ISN36_18500	COG2062	phosphohistidine phosphatase, SixA
ISN36_18510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN36_18515	COG2050	protein possibly involved in aromatic compounds catabolism
ISN36_18525	COG2267	carboxylic ester hydrolase activity
ISN36_18540	COG1881	PFAM PEBP family protein
ISN36_18545	COG1968	undecaprenyl-diphosphatase activity
ISN36_18550	COG0174	glutamine synthetase
ISN36_18555	COG0347	Belongs to the P(II) protein family
ISN36_18560	COG0004	ammonium transporteR
ISN36_18565	COG3852	Histidine kinase
ISN36_18570	COG2204	response regulator
ISN36_18575	COG2032	superoxide dismutase activity
ISN36_18580	COG2032	superoxide dismutase activity
ISN36_18590	COG0183	Belongs to the thiolase family
ISN36_18630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN36_18635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN36_18645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN36_18655	COG0612	Peptidase, M16
ISN36_18665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN36_18675	COG0596	Alpha beta hydrolase
ISN36_18685	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN36_18690	COG0318	PFAM AMP-dependent synthetase and ligase
ISN36_18705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN36_18715	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN36_18730	COG4232	protein-disulfide reductase activity
ISN36_18735	COG0564	pseudouridine synthase activity
ISN36_18755	COG0339	signal peptide processing
ISN36_18775	COG0583	DNA-binding transcription factor activity
ISN36_18780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN36_18785	COG2224	Isocitrate lyase
ISN36_18820	COG0659	secondary active sulfate transmembrane transporter activity
ISN36_18855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN36_18860	COG2130	NADP-dependent
ISN36_18875	COG1187	pseudouridine synthase activity
ISN36_18895	COG0084	hydrolase, TatD family'
ISN36_18910	COG0842	Transport permease protein
ISN36_18915	COG1131	(ABC) transporter
ISN36_18920	COG0633	Ferredoxin
ISN36_18920	COG0543	2 iron, 2 sulfur cluster binding
ISN36_18930	COG1476	TRANSCRIPTIONal
ISN36_18940	COG4555	ABC transporter
ISN36_18960	COG0625	glutathione transferase activity
ISN36_19040	COG1199	ATP-dependent helicase activity
ISN36_19105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN36_19125	COG0628	permease
ISN36_19135	COG2133	pyrroloquinoline quinone binding
ISN36_19175	COG0754	glutathionylspermidine amidase activity
ISN36_19185	COG0714	Associated with various cellular activities
ISN36_19230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN36_19245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN36_19250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN36_19275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN36_19300	COG1028	Short-chain dehydrogenase reductase Sdr
ISN36_19315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN36_19325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN36_19355	COG0606	chelatase, subunit chli
ISN36_19360	COG2960	long-chain fatty acid transporting porin activity
ISN36_19390	COG1166	arginine decarboxylase activity
ISN36_19400	COG1819	glycosyl
ISN36_19405	COG2755	lipolytic protein G-D-S-L family
ISN36_19405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN36_19410	COG0583	DNA-binding transcription factor activity
ISN36_19430	COG4221	oxidoreductase activity
ISN36_19450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN36_19470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN36_19480	COG2814	Major facilitator Superfamily
ISN36_19495	COG0739	heme binding
ISN36_19500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN36_19575	COG0629	single-stranded DNA binding
ISN36_19735	COG2948	multi-organism process
ISN36_19745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN36_19900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN36_20000	COG3451	type IV secretory pathway VirB4
ISN36_20005	COG5268	conjugation