locus-tag	class	description
ISN38_00020	COG1558	bacterial-type flagellum-dependent cell motility
ISN38_00030	COG0784	Response regulator, receiver
ISN38_00030	COG0835	chemotaxis
ISN38_00090	COG2915	High frequency lysogenization protein hflD homolog
ISN38_00095	COG0482	sulfurtransferase activity
ISN38_00115	COG0542	response to heat
ISN38_00125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ISN38_00135	COG0492	ferredoxin-NADP+ reductase activity
ISN38_00140	COG1674	ftsk spoiiie
ISN38_00160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISN38_00165	COG0038	chloride channel
ISN38_00220	COG1595	DNA-templated transcription, initiation
ISN38_00240	COG3038	cytochrome b561
ISN38_00270	COG2244	polysaccharide biosynthetic process
ISN38_00290	COG4106	trans-aconitate 2-methyltransferase activity
ISN38_00310	COG0438	transferase activity, transferring glycosyl groups
ISN38_00315	COG0438	transferase activity, transferring glycosyl groups
ISN38_00330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISN38_00335	COG2258	MOSC domain
ISN38_00345	COG0505	Belongs to the CarA family
ISN38_00355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISN38_00360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN38_00450	COG1074	ATP-dependent DNA helicase activity
ISN38_00495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN38_00500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISN38_00515	COG1024	Enoyl-CoA hydratase
ISN38_00525	COG1024	Enoyl-CoA hydratase
ISN38_00530	COG1024	Enoyl-CoA hydratase
ISN38_00570	COG0346	lactoylglutathione lyase activity
ISN38_00580	COG1304	FMN binding
ISN38_00585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN38_00590	COG1649	PFAM Uncharacterised BCR, COG1649
ISN38_00620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN38_00655	COG0784	Response regulator, receiver
ISN38_00655	COG2205	protein histidine kinase activity
ISN38_00660	COG2183	response to ionizing radiation
ISN38_00665	COG0784	Response regulator, receiver
ISN38_00665	COG4191	Histidine kinase
ISN38_00675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ISN38_00675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN38_00695	COG3243	poly(R)-hydroxyalkanoic acid synthase
ISN38_00705	COG1183	phosphatidylcholine synthase activity
ISN38_00710	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_00725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISN38_00735	COG0668	transmembrane transport
ISN38_00740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISN38_00755	COG1914	H( )-stimulated, divalent metal cation uptake system
ISN38_00765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN38_00770	COG1501	Belongs to the glycosyl hydrolase 31 family
ISN38_00775	COG0519	Catalyzes the synthesis of GMP from XMP
ISN38_00775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN38_00785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISN38_00805	COG0475	glutathione-regulated potassium exporter activity
ISN38_00805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN38_00810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISN38_00820	COG0746	molybdenum cofactor guanylyltransferase activity
ISN38_00830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN38_00840	COG1426	Protein conserved in bacteria
ISN38_00850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISN38_00865	COG1024	Enoyl-CoA hydratase
ISN38_00865	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN38_00870	COG0183	Belongs to the thiolase family
ISN38_00875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISN38_00885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISN38_00890	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISN38_00900	COG0776	regulation of translation
ISN38_00905	COG0539	negative regulation of cytoplasmic translation
ISN38_00910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISN38_00915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISN38_00925	COG2957	Belongs to the agmatine deiminase family
ISN38_00930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN38_00950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN38_00970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISN38_00970	COG0316	Belongs to the HesB IscA family
ISN38_00985	COG0428	transporter
ISN38_01000	COG1530	ribonuclease E activity
ISN38_01025	COG1132	(ABC) transporter
ISN38_01065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN38_01075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISN38_01080	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ISN38_01115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN38_01130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISN38_01140	COG1663	tetraacyldisaccharide 4'-kinase activity
ISN38_01145	COG1132	(ABC) transporter
ISN38_01155	COG0811	peptide transport
ISN38_01175	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISN38_01185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ISN38_01190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISN38_01200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISN38_01205	COG2009	succinate dehydrogenase
ISN38_01225	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN38_01240	COG0129	dihydroxy-acid dehydratase activity
ISN38_01255	COG0395	ABC-type sugar transport system, permease component
ISN38_01290	COG2350	Protein conserved in bacteria
ISN38_01295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISN38_01300	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISN38_01305	COG1187	pseudouridine synthase activity
ISN38_01345	COG0436	Aminotransferase
ISN38_01350	COG4133	protoheme IX ABC transporter activity
ISN38_01395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN38_01400	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISN38_01405	COG4988	ABC transporter
ISN38_01415	COG1294	oxidase, subunit
ISN38_01440	COG2902	Dehydrogenase
ISN38_01450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN38_01455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN38_01470	COG0556	nucleotide-excision repair
ISN38_01545	COG1960	acyl-CoA dehydrogenase activity
ISN38_01550	COG2226	methyltransferase
ISN38_01555	COG1410	methionine synthase
ISN38_01555	COG0646	methionine synthase
ISN38_01560	COG1410	methionine synthase
ISN38_01560	COG0646	methionine synthase
ISN38_01580	COG2900	Belongs to the SlyX family
ISN38_01595	COG0386	Belongs to the glutathione peroxidase family
ISN38_01605	COG1725	Transcriptional regulator
ISN38_01610	COG1131	(ABC) transporter
ISN38_01655	COG2885	chlorophyll binding
ISN38_01660	COG2850	peptidyl-arginine hydroxylation
ISN38_01710	COG1132	(ABC) transporter
ISN38_01720	COG0287	Prephenate dehydrogenase
ISN38_01720	COG1605	Chorismate mutase
ISN38_01725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ISN38_01730	COG0484	heat shock protein binding
ISN38_01735	COG0443	Heat shock 70 kDa protein
ISN38_01740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISN38_01745	COG1420	regulation of RNA biosynthetic process
ISN38_01750	COG0497	DNA recombination
ISN38_01755	COG0735	belongs to the Fur family
ISN38_01760	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN38_01770	COG2867	negative regulation of translational initiation
ISN38_01775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISN38_01780	COG1404	Belongs to the peptidase S8 family
ISN38_01815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN38_01830	COG0583	DNA-binding transcription factor activity
ISN38_01845	COG0415	Belongs to the DNA photolyase family
ISN38_01850	COG0305	Participates in initiation and elongation during chromosome replication
ISN38_01860	COG1960	acyl-CoA dehydrogenase activity
ISN38_01875	COG0084	hydrolase, TatD family'
ISN38_01880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISN38_01930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISN38_01955	COG0386	Belongs to the glutathione peroxidase family
ISN38_01970	COG1846	Transcriptional regulator
ISN38_02010	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN38_02020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISN38_02035	COG0488	(ABC) transporter
ISN38_02040	COG0513	Belongs to the DEAD box helicase family
ISN38_02065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ISN38_02070	COG0657	acetylesterase activity
ISN38_02075	COG0625	glutathione transferase activity
ISN38_02085	COG0564	pseudouridine synthase activity
ISN38_02090	COG4681	YaeQ
ISN38_02095	COG2081	HI0933 family
ISN38_02115	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_02135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISN38_02140	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN38_02145	COG0802	atpase or kinase
ISN38_02150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISN38_02150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISN38_02155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN38_02200	COG1960	acyl-CoA dehydrogenase activity
ISN38_02210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ISN38_02230	COG0438	transferase activity, transferring glycosyl groups
ISN38_02240	COG0438	transferase activity, transferring glycosyl groups
ISN38_02245	COG0438	transferase activity, transferring glycosyl groups
ISN38_02295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISN38_02300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISN38_02310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISN38_02340	COG1024	Enoyl-CoA hydratase
ISN38_02355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISN38_02375	COG0277	FAD linked oxidase domain protein
ISN38_02380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISN38_02395	COG0531	amino acid
ISN38_02400	COG0531	amino acid
ISN38_02405	COG0235	Class ii aldolase
ISN38_02410	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ISN38_02415	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ISN38_02430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISN38_02430	COG0140	phosphoribosyl-ATP diphosphatase activity
ISN38_02445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISN38_02460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISN38_02465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISN38_02475	COG0124	histidyl-tRNA synthetase
ISN38_02480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN38_02490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISN38_02500	COG2951	lytic endotransglycosylase activity
ISN38_02505	COG0083	homoserine kinase activity
ISN38_02510	COG0527	aspartate kinase activity
ISN38_02510	COG0460	homoserine dehydrogenase
ISN38_02525	COG1012	belongs to the aldehyde dehydrogenase family
ISN38_02540	COG0167	dihydroorotate dehydrogenase activity
ISN38_02545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISN38_02570	COG0671	phosphoesterase, PA-phosphatase related
ISN38_02585	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ISN38_02685	COG0166	Belongs to the GPI family
ISN38_02700	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ISN38_02710	COG0617	tRNA 3'-terminal CCA addition
ISN38_02730	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISN38_02735	COG0477	Major facilitator Superfamily
ISN38_02740	COG2115	Belongs to the xylose isomerase family
ISN38_02745	COG1070	Carbohydrate kinase
ISN38_02760	COG2801	Transposase and inactivated derivatives
ISN38_02765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ISN38_02785	COG0165	Argininosuccinate lyase
ISN38_02790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISN38_02800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISN38_02805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN38_02810	COG0137	argininosuccinate synthase activity
ISN38_02815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ISN38_02830	COG2166	iron-sulfur cluster assembly
ISN38_02900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN38_02910	COG4677	pectinesterase activity
ISN38_02920	COG4677	pectinesterase activity
ISN38_02940	COG0402	S-adenosylhomocysteine deaminase activity
ISN38_02945	COG3548	integral membrane protein
ISN38_02955	COG1509	lysine 2,3-aminomutase activity
ISN38_02960	COG3706	GGDEF domain
ISN38_02960	COG2203	Gaf domain
ISN38_02960	COG4251	negative regulation of phosphorylation
ISN38_02960	COG5001	Diguanylate cyclase
ISN38_02985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN38_02990	COG1862	Preprotein translocase
ISN38_03000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISN38_03010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN38_03020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISN38_03025	COG3291	Pkd domain containing protein
ISN38_03030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN38_03035	COG0405	Gamma-glutamyltransferase
ISN38_03040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISN38_03055	COG0742	ribosomal rna small subunit methyltransferase
ISN38_03080	COG4771	TonB-dependent receptor
ISN38_03090	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN38_03125	COG0531	amino acid
ISN38_03140	COG0006	proline dipeptidase activity
ISN38_03150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN38_03165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN38_03170	COG3938	Belongs to the proline racemase family
ISN38_03180	COG0552	protein localization to endoplasmic reticulum
ISN38_03185	COG1194	a g-specific adenine glycosylase
ISN38_03230	COG0835	chemotaxis
ISN38_03235	COG0840	transmembrane signaling receptor activity
ISN38_03240	COG0840	transmembrane signaling receptor activity
ISN38_03260	COG3300	MHYT domain
ISN38_03260	COG5001	Diguanylate cyclase
ISN38_03265	COG1185	polyribonucleotide nucleotidyltransferase activity
ISN38_03290	COG0195	Participates in both transcription termination and antitermination
ISN38_03305	COG1007	ATP synthesis coupled electron transport
ISN38_03320	COG0713	ATP synthesis coupled electron transport
ISN38_03345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ISN38_03350	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ISN38_03355	COG0649	NAD binding
ISN38_03360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN38_03370	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISN38_03390	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_03415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISN38_03460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISN38_03475	COG2890	protein-(glutamine-N5) methyltransferase activity
ISN38_03485	COG0688	phosphatidylethanolamine metabolic process
ISN38_03490	COG0741	lytic transglycosylase activity
ISN38_03495	COG0433	COG0433 Predicted ATPase
ISN38_03500	COG0494	nUDIX hydrolase
ISN38_03515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN38_03535	COG1714	RDD family
ISN38_03540	COG0717	Belongs to the dCTP deaminase family
ISN38_03545	COG0489	protein tyrosine kinase activity
ISN38_03565	COG4771	TonB-dependent receptor
ISN38_03570	COG4771	TonB-dependent receptor
ISN38_03575	COG0457	Tetratricopeptide repeat
ISN38_03590	COG3590	peptidase
ISN38_03640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN38_03645	COG2311	Membrane
ISN38_03650	COG1047	Peptidyl-prolyl cis-trans
ISN38_03655	COG0791	NLP P60 protein
ISN38_03660	COG0791	NLP P60 protein
ISN38_03675	COG1607	acyl-coa hydrolase
ISN38_03685	COG1301	dicarboxylic acid transport
ISN38_03690	COG1785	Belongs to the alkaline phosphatase family
ISN38_03700	COG0037	tRNA processing
ISN38_03705	COG1722	exodeoxyribonuclease VII activity
ISN38_03710	COG0142	geranyltranstransferase activity
ISN38_03720	COG1858	cytochrome C peroxidase
ISN38_03745	COG0515	serine threonine protein kinase
ISN38_03745	COG2815	serine threonine protein kinase
ISN38_03750	COG0631	protein serine/threonine phosphatase activity
ISN38_03840	COG0312	modulator of DNA gyrase
ISN38_03850	COG0312	modulator of DNA gyrase
ISN38_03870	COG2968	Membrane
ISN38_03885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISN38_03900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISN38_03915	COG0495	leucyl-tRNA aminoacylation
ISN38_03925	COG3118	belongs to the thioredoxin family
ISN38_03945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISN38_03955	COG2040	homocysteine
ISN38_03960	COG0833	amino acid
ISN38_03970	COG0346	lactoylglutathione lyase activity
ISN38_03990	COG2878	Part of a membrane complex involved in electron transport
ISN38_04005	COG1595	DNA-templated transcription, initiation
ISN38_04030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISN38_04050	COG0251	oxidation-reduction process
ISN38_04060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISN38_04060	COG0392	lysyltransferase activity
ISN38_04090	COG2814	Major facilitator Superfamily
ISN38_04100	COG1902	pentaerythritol trinitrate reductase activity
ISN38_04105	COG2824	Alkylphosphonate utilization operon protein PhnA
ISN38_04110	COG1047	Peptidyl-prolyl cis-trans
ISN38_04115	COG1077	Cell shape determining protein MreB Mrl
ISN38_04150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ISN38_04160	COG1451	nucleotide metabolic process
ISN38_04185	COG0784	Response regulator, receiver
ISN38_04185	COG2198	Histidine kinase
ISN38_04185	COG2205	protein histidine kinase activity
ISN38_04195	COG2186	Transcriptional regulator
ISN38_04265	COG1703	isobutyryl-CoA mutase activity
ISN38_04265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN38_04265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ISN38_04295	COG0183	Belongs to the thiolase family
ISN38_04305	COG0443	Heat shock 70 kDa protein
ISN38_04335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN38_04335	COG1793	dna ligase
ISN38_04340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ISN38_04340	COG1793	dna ligase
ISN38_04345	COG1201	RNA secondary structure unwinding
ISN38_04355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN38_04360	COG1278	Cold shock
ISN38_04365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISN38_04370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISN38_04375	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN38_04385	COG2954	triphosphatase activity
ISN38_04395	COG0745	RESPONSE REGULATOR receiver
ISN38_04405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISN38_04420	COG0681	Belongs to the peptidase S26 family
ISN38_04425	COG0481	GTPase activity
ISN38_04430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN38_04445	COG1024	Enoyl-CoA hydratase
ISN38_04445	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISN38_04460	COG2855	membrane
ISN38_04475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISN38_04495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISN38_04505	COG0534	Mate efflux family protein
ISN38_04510	COG0335	large ribosomal subunit rRNA binding
ISN38_04515	COG0336	Belongs to the RNA methyltransferase TrmD family
ISN38_04520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISN38_04535	COG2070	2-Nitropropane dioxygenase
ISN38_04540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISN38_04565	COG0475	glutathione-regulated potassium exporter activity
ISN38_04575	COG0625	glutathione transferase activity
ISN38_04580	COG1082	Xylose isomerase domain protein TIM barrel
ISN38_04590	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN38_04595	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISN38_04600	COG1129	ABC transporter
ISN38_04605	COG1879	ABC-type sugar transport system periplasmic component
ISN38_04610	COG1012	belongs to the aldehyde dehydrogenase family
ISN38_04630	COG0129	dihydroxy-acid dehydratase activity
ISN38_04655	COG2207	Transcriptional regulator
ISN38_04675	COG1317	bacterial-type flagellum organization
ISN38_04700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISN38_04725	COG4794	Type iii secretion
ISN38_04755	COG0745	RESPONSE REGULATOR receiver
ISN38_04785	COG3152	Membrane
ISN38_04795	COG0156	8-amino-7-oxononanoate synthase activity
ISN38_04805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISN38_04810	COG1845	cytochrome c oxidase, subunit III
ISN38_04815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN38_04835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ISN38_04850	COG0196	riboflavin kinase activity
ISN38_04870	COG0728	peptidoglycan biosynthetic process
ISN38_04890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISN38_04895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISN38_04900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISN38_04905	COG0824	Thioesterase
ISN38_04915	COG1024	Enoyl-CoA hydratase
ISN38_04920	COG1946	Acyl-CoA thioesterase
ISN38_04930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN38_04935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ISN38_04950	COG4638	Rieske (2fe-2S)
ISN38_04995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN38_05040	COG1643	Atp-dependent helicase
ISN38_05045	COG0783	Belongs to the Dps family
ISN38_05050	COG0514	ATP-dependent DNA helicase (RecQ)
ISN38_05070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISN38_05075	COG0602	queuosine metabolic process
ISN38_05085	COG2885	chlorophyll binding
ISN38_05100	COG0848	biopolymer transport protein
ISN38_05110	COG0824	Thioesterase
ISN38_05115	COG2255	four-way junction helicase activity
ISN38_05120	COG3158	transport of potassium into the cell
ISN38_05125	COG0632	four-way junction helicase activity
ISN38_05135	COG0217	transcriptional regulatory protein
ISN38_05155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISN38_05175	COG3142	Participates in the control of copper homeostasis
ISN38_05180	COG1446	asparaginase
ISN38_05200	COG2201	protein-glutamate methylesterase activity
ISN38_05205	COG0784	Response regulator, receiver
ISN38_05205	COG2198	Histidine kinase
ISN38_05205	COG0643	Histidine kinase
ISN38_05210	COG0840	transmembrane signaling receptor activity
ISN38_05215	COG0835	chemotaxis
ISN38_05230	COG0189	ligase activity
ISN38_05250	COG1199	ATP-dependent helicase activity
ISN38_05260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN38_05265	COG1216	Glycosyl transferase, family 2
ISN38_05270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISN38_05290	COG4585	Histidine kinase
ISN38_05300	COG0850	regulation of cytokinetic process
ISN38_05305	COG2894	cell division
ISN38_05310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISN38_05320	COG2205	protein histidine kinase activity
ISN38_05325	COG0745	RESPONSE REGULATOR receiver
ISN38_05335	COG2194	sulfuric ester hydrolase activity
ISN38_05355	COG2814	Major facilitator Superfamily
ISN38_05380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN38_05380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISN38_05390	COG0753	catalase activity
ISN38_05400	COG4106	trans-aconitate 2-methyltransferase activity
ISN38_05415	COG1063	alcohol dehydrogenase
ISN38_05425	COG3459	Glycosyltransferase 36 associated
ISN38_05480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISN38_05490	COG0330	HflC and HflK could
ISN38_05495	COG0330	HflC and HflK could
ISN38_05500	COG0604	alcohol dehydrogenase
ISN38_05520	COG0678	peroxiredoxin activity
ISN38_05550	COG2373	Large extracellular alpha-helical protein
ISN38_05575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISN38_05590	COG0372	Belongs to the citrate synthase family
ISN38_05595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN38_05610	COG0587	DNA-directed DNA polymerase activity
ISN38_05645	COG2161	toxin-antitoxin pair type II binding
ISN38_05650	COG4115	mRNA cleavage
ISN38_05670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISN38_05675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISN38_05680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISN38_05690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN38_05695	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_05700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISN38_05705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN38_05715	COG1399	metal-binding, possibly nucleic acid-binding protein
ISN38_05740	COG0714	Associated with various cellular activities
ISN38_05760	COG0537	adenosine 5'-monophosphoramidase activity
ISN38_05800	COG0314	molybdopterin synthase activity
ISN38_05805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISN38_05810	COG0315	cyclic pyranopterin monophosphate synthase activity
ISN38_05820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISN38_05825	COG1234	tRNA 3'-trailer cleavage
ISN38_05835	COG0859	PFAM glycosyl transferase family 9
ISN38_05855	COG0631	protein serine/threonine phosphatase activity
ISN38_05860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN38_05865	COG0328	RNA-DNA hybrid ribonuclease activity
ISN38_05875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISN38_05880	COG1388	LysM domain
ISN38_05880	COG3942	CHAP domain
ISN38_05915	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISN38_05925	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISN38_05965	COG0473	3-isopropylmalate dehydrogenase activity
ISN38_05980	COG4783	chaperone-mediated protein folding
ISN38_05995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISN38_06000	COG0248	Ppx GppA phosphatase
ISN38_06005	COG0438	transferase activity, transferring glycosyl groups
ISN38_06015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN38_06025	COG3291	Pkd domain containing protein
ISN38_06030	COG2833	Protein of unknown function (DUF455)
ISN38_06050	COG0285	dihydrofolate synthase activity
ISN38_06055	COG0588	phosphoglycerate mutase activity
ISN38_06075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISN38_06080	COG4208	sulfate ABC transporter
ISN38_06085	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISN38_06090	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISN38_06095	COG0156	8-amino-7-oxononanoate synthase activity
ISN38_06110	COG2885	chlorophyll binding
ISN38_06130	COG0667	Aldo Keto reductase
ISN38_06140	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISN38_06140	COG1902	pentaerythritol trinitrate reductase activity
ISN38_06185	COG0625	glutathione transferase activity
ISN38_06200	COG0039	L-malate dehydrogenase activity
ISN38_06210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISN38_06215	COG1217	gtp-binding protein TYPA
ISN38_06230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ISN38_06240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ISN38_06245	COG0203	ribosomal protein L17
ISN38_06270	COG0201	protein transport
ISN38_06280	COG1841	ribosomal large subunit assembly
ISN38_06310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISN38_06315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISN38_06325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISN38_06330	COG0255	Belongs to the universal ribosomal protein uL29 family
ISN38_06355	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISN38_06360	COG0089	rRNA binding
ISN38_06365	COG0088	Forms part of the polypeptide exit tunnel
ISN38_06375	COG0051	transcription antitermination factor activity, RNA binding
ISN38_06380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN38_06385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISN38_06400	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISN38_06410	COG0222	ribosome binding
ISN38_06425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISN38_06430	COG0250	Participates in transcription elongation, termination and antitermination
ISN38_06435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISN38_06445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISN38_06465	COG0012	GTP binding
ISN38_06470	COG0193	aminoacyl-tRNA hydrolase activity
ISN38_06480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISN38_06490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISN38_06505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISN38_06510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISN38_06560	COG0488	(ABC) transporter
ISN38_06600	COG3634	alkyl hydroperoxide reductase activity
ISN38_06605	COG0583	DNA-binding transcription factor activity
ISN38_06615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISN38_06620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISN38_06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISN38_06655	COG0697	spore germination
ISN38_06695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN38_06700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISN38_06710	COG2096	Adenosyltransferase
ISN38_06720	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISN38_06725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISN38_06730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ISN38_06735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN38_06740	COG2967	ApaG domain
ISN38_06745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ISN38_06775	COG1704	LemA family
ISN38_06780	COG0861	Integral membrane protein TerC family
ISN38_06785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISN38_06795	COG0642	Histidine kinase
ISN38_06810	COG4181	ATPase activity
ISN38_06815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISN38_06835	COG4771	TonB-dependent receptor
ISN38_06845	COG0667	Aldo Keto reductase
ISN38_06850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISN38_06870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN38_06885	COG0372	Belongs to the citrate synthase family
ISN38_06890	COG0254	rRNA binding
ISN38_06900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISN38_06920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISN38_06925	COG1758	RNA polymerase activity
ISN38_06930	COG0194	GDP metabolic process
ISN38_06935	COG1561	YicC-like family, N-terminal region
ISN38_06940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ISN38_06945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISN38_06950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISN38_06985	COG1056	cytidyltransferase-related domain
ISN38_06985	COG1051	belongs to the nudix hydrolase family
ISN38_07010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ISN38_07045	COG1686	Belongs to the peptidase S11 family
ISN38_07055	COG2951	lytic endotransglycosylase activity
ISN38_07075	COG0772	Belongs to the SEDS family
ISN38_07080	COG0768	penicillin binding
ISN38_07090	COG1792	Involved in formation and maintenance of cell shape
ISN38_07095	COG1077	Cell shape determining protein MreB Mrl
ISN38_07100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN38_07105	COG3284	Transcriptional regulator
ISN38_07120	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN38_07120	COG0596	Alpha beta hydrolase
ISN38_07125	COG0308	aminopeptidase N
ISN38_07130	COG2226	methyltransferase
ISN38_07155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISN38_07175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ISN38_07185	COG2832	Protein of unknown function (DUF454)
ISN38_07195	COG0436	Aminotransferase
ISN38_07210	COG1505	serine-type exopeptidase activity
ISN38_07225	COG1733	regulation of RNA biosynthetic process
ISN38_07240	COG0181	hydroxymethylbilane synthase activity
ISN38_07265	COG0745	RESPONSE REGULATOR receiver
ISN38_07285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ISN38_07290	COG1640	4-alpha-glucanotransferase
ISN38_07315	COG0243	molybdopterin cofactor binding
ISN38_07320	COG2146	nitrite reductase [NAD(P)H] activity
ISN38_07325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN38_07330	COG2223	nitrite transmembrane transporter activity
ISN38_07335	COG1116	anion transmembrane transporter activity
ISN38_07335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISN38_07345	COG1648	precorrin-2 dehydrogenase activity
ISN38_07345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN38_07370	COG0732	type I restriction modification DNA specificity domain
ISN38_07375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ISN38_07405	COG4191	Histidine kinase
ISN38_07410	COG0028	Belongs to the TPP enzyme family
ISN38_07425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISN38_07440	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ISN38_07450	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_07455	COG3685	Protein conserved in bacteria
ISN38_07460	COG3685	Protein conserved in bacteria
ISN38_07465	COG3546	catalase activity
ISN38_07480	COG0840	transmembrane signaling receptor activity
ISN38_07520	COG1309	transcriptional regulator
ISN38_07570	COG0366	Alpha amylase catalytic
ISN38_07575	COG0366	Alpha amylase catalytic
ISN38_07585	COG1609	Transcriptional regulator
ISN38_07615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN38_07620	COG1490	D-aminoacyl-tRNA deacylase activity
ISN38_07630	COG1247	-acetyltransferase
ISN38_07635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISN38_07670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ISN38_07675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN38_07675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISN38_07680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISN38_07685	COG0242	peptide deformylase activity
ISN38_07690	COG1652	LysM domain
ISN38_07695	COG0758	DNA mediated transformation
ISN38_07710	COG1714	RDD family
ISN38_07715	COG1754	DNA topoisomerase type I activity
ISN38_07715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN38_07720	COG0009	L-threonylcarbamoyladenylate synthase
ISN38_07740	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_07750	COG0616	signal peptide processing
ISN38_07755	COG0534	Mate efflux family protein
ISN38_07765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISN38_07775	COG1252	NADH dehydrogenase
ISN38_07780	COG2860	membrane
ISN38_07785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISN38_07790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISN38_07795	COG2201	protein-glutamate methylesterase activity
ISN38_07800	COG2177	Part of the ABC transporter FtsEX involved in
ISN38_07805	COG2884	Cell division ATP-binding protein ftsE
ISN38_07815	COG3118	belongs to the thioredoxin family
ISN38_07820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISN38_07850	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ISN38_07895	COG1518	maintenance of DNA repeat elements
ISN38_07900	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ISN38_07910	COG1652	LysM domain
ISN38_07925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN38_07930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN38_07945	COG5383	Protein conserved in bacteria
ISN38_07995	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISN38_08000	COG4771	TonB-dependent receptor
ISN38_08010	COG4948	Mandelate Racemase Muconate Lactonizing
ISN38_08020	COG0531	amino acid
ISN38_08040	COG2133	pyrroloquinoline quinone binding
ISN38_08055	COG2308	Evidence 4 Homologs of previously reported genes of
ISN38_08060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISN38_08080	COG1295	ribonuclease BN
ISN38_08085	COG0358	DNA primase activity
ISN38_08100	COG0109	protoheme IX farnesyltransferase activity
ISN38_08130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
ISN38_08135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISN38_08140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISN38_08140	COG1565	acr, cog1565
ISN38_08165	COG0531	amino acid
ISN38_08195	COG0793	Belongs to the peptidase S41A family
ISN38_08200	COG4942	peptidase
ISN38_08210	COG2234	aminopeptidase activity
ISN38_08215	COG1064	alcohol dehydrogenase
ISN38_08245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISN38_08250	COG0739	heme binding
ISN38_08265	COG2814	Major facilitator Superfamily
ISN38_08275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISN38_08295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISN38_08315	COG4221	oxidoreductase activity
ISN38_08335	COG0583	DNA-binding transcription factor activity
ISN38_08340	COG2755	lipolytic protein G-D-S-L family
ISN38_08340	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ISN38_08345	COG1819	glycosyl
ISN38_08355	COG1166	arginine decarboxylase activity
ISN38_08380	COG2960	long-chain fatty acid transporting porin activity
ISN38_08385	COG0606	chelatase, subunit chli
ISN38_08415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISN38_08425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISN38_08440	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_08465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISN38_08490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISN38_08495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN38_08510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISN38_08555	COG0714	Associated with various cellular activities
ISN38_08565	COG0754	glutathionylspermidine amidase activity
ISN38_08605	COG2133	pyrroloquinoline quinone binding
ISN38_08615	COG0628	permease
ISN38_08635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN38_08700	COG1199	ATP-dependent helicase activity
ISN38_08780	COG0625	glutathione transferase activity
ISN38_08800	COG4555	ABC transporter
ISN38_08810	COG1476	TRANSCRIPTIONal
ISN38_08820	COG0543	2 iron, 2 sulfur cluster binding
ISN38_08820	COG0633	Ferredoxin
ISN38_08825	COG1131	(ABC) transporter
ISN38_08830	COG0842	Transport permease protein
ISN38_08845	COG0084	hydrolase, TatD family'
ISN38_08865	COG1187	pseudouridine synthase activity
ISN38_08880	COG2130	NADP-dependent
ISN38_08885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN38_08920	COG0659	secondary active sulfate transmembrane transporter activity
ISN38_08955	COG2224	Isocitrate lyase
ISN38_08960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISN38_08965	COG0583	DNA-binding transcription factor activity
ISN38_08985	COG0339	signal peptide processing
ISN38_09005	COG0564	pseudouridine synthase activity
ISN38_09010	COG4232	protein-disulfide reductase activity
ISN38_09025	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN38_09035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN38_09050	COG0318	PFAM AMP-dependent synthetase and ligase
ISN38_09055	COG0727	PFAM Uncharacterised protein family (UPF0153)
ISN38_09065	COG0596	Alpha beta hydrolase
ISN38_09075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN38_09085	COG0612	Peptidase, M16
ISN38_09095	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISN38_09105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISN38_09110	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ISN38_09150	COG0183	Belongs to the thiolase family
ISN38_09160	COG2032	superoxide dismutase activity
ISN38_09165	COG2032	superoxide dismutase activity
ISN38_09170	COG2204	response regulator
ISN38_09175	COG3852	Histidine kinase
ISN38_09180	COG0004	ammonium transporteR
ISN38_09185	COG0347	Belongs to the P(II) protein family
ISN38_09190	COG0174	glutamine synthetase
ISN38_09195	COG1968	undecaprenyl-diphosphatase activity
ISN38_09200	COG1881	PFAM PEBP family protein
ISN38_09215	COG2267	carboxylic ester hydrolase activity
ISN38_09225	COG2050	protein possibly involved in aromatic compounds catabolism
ISN38_09230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN38_09240	COG2062	phosphohistidine phosphatase, SixA
ISN38_09245	COG1192	Involved in chromosome partitioning
ISN38_09290	COG2271	Major facilitator Superfamily
ISN38_09325	COG1205	dead DEAH box helicase
ISN38_09325	COG1111	helicase
ISN38_09370	COG0070	glutamate synthase
ISN38_09370	COG0069	glutamate synthase activity
ISN38_09370	COG0067	glutamate synthase
ISN38_09375	COG0493	'glutamate synthase
ISN38_09380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN38_09385	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN38_09390	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN38_09450	COG2951	lytic endotransglycosylase activity
ISN38_09465	COG0730	response to heat
ISN38_09490	COG0302	gtp cyclohydrolase
ISN38_09495	COG0477	Major facilitator Superfamily
ISN38_09565	COG0537	adenosine 5'-monophosphoramidase activity
ISN38_09585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISN38_09590	COG1074	ATP-dependent DNA helicase activity
ISN38_09595	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISN38_09600	COG1127	ABC transporter
ISN38_09605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN38_09610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN38_09625	COG2853	Lipoprotein
ISN38_09630	COG0386	Belongs to the glutathione peroxidase family
ISN38_09635	COG1322	Protein conserved in bacteria
ISN38_09655	COG4191	Histidine kinase
ISN38_09660	COG4566	intracellular signal transduction
ISN38_09665	COG0531	amino acid
ISN38_09710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISN38_09725	COG0671	phosphoesterase, PA-phosphatase related
ISN38_09745	COG1752	Esterase of the alpha-beta hydrolase superfamily
ISN38_09765	COG1522	sequence-specific DNA binding
ISN38_09770	COG3186	Phenylalanine-4-hydroxylase
ISN38_09785	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_09795	COG1609	Transcriptional regulator
ISN38_09800	COG3507	Belongs to the glycosyl hydrolase 43 family
ISN38_09815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISN38_09860	COG4771	TonB-dependent receptor
ISN38_09880	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISN38_09955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN38_09990	COG1304	FMN binding
ISN38_10025	COG1012	belongs to the aldehyde dehydrogenase family
ISN38_10030	COG3284	Transcriptional regulator
ISN38_10040	COG4772	TonB-dependent receptor
ISN38_10055	COG1280	lysine exporter protein (LysE YggA)
ISN38_10070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN38_10110	COG0501	Belongs to the peptidase M48B family
ISN38_10115	COG1266	CAAX protease self-immunity
ISN38_10120	COG0187	DNA topoisomerase II activity
ISN38_10125	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISN38_10145	COG0594	ribonuclease P activity
ISN38_10150	COG0706	membrane insertase activity
ISN38_10165	COG1119	ATPase activity
ISN38_10180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ISN38_10205	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ISN38_10215	COG1435	thymidine kinase activity
ISN38_10220	COG0210	DNA helicase
ISN38_10240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN38_10245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISN38_10245	COG0519	Catalyzes the synthesis of GMP from XMP
ISN38_10255	COG0805	protein transport
ISN38_10265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISN38_10275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISN38_10295	COG0037	tRNA processing
ISN38_10300	COG2115	Belongs to the xylose isomerase family
ISN38_10310	COG3661	Belongs to the glycosyl hydrolase 67 family
ISN38_10320	COG4948	Mandelate Racemase Muconate Lactonizing
ISN38_10330	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN38_10335	COG0246	Mannitol dehydrogenase
ISN38_10355	COG3386	PFAM SMP-30 Gluconolaconase
ISN38_10375	COG3693	PFAM glycoside hydrolase, family 10
ISN38_10390	COG2211	Major facilitator Superfamily
ISN38_10415	COG2937	Belongs to the GPAT DAPAT family
ISN38_10425	COG1609	Transcriptional regulator
ISN38_10450	COG0284	orotidine-5'-phosphate decarboxylase activity
ISN38_10510	COG3132	Protein of unknown function, DUF480
ISN38_10540	COG0729	surface antigen
ISN38_10545	COG2911	Protein conserved in bacteria
ISN38_10560	COG3265	gluconokinase activity
ISN38_10565	COG2211	Major facilitator Superfamily
ISN38_10570	COG3459	Glycosyltransferase 36 associated
ISN38_10580	COG2205	protein histidine kinase activity
ISN38_10585	COG1971	Probably functions as a manganese efflux pump
ISN38_10605	COG0477	Major facilitator Superfamily
ISN38_10630	COG2091	lysine biosynthetic process via aminoadipic acid
ISN38_10645	COG0357	Ribosomal RNA small subunit methyltransferase G
ISN38_10650	COG1192	Involved in chromosome partitioning
ISN38_10655	COG1475	DNA binding
ISN38_10665	COG0463	Glycosyl transferase, family 2
ISN38_10715	COG0210	DNA helicase
ISN38_10735	COG0589	response to stress
ISN38_10750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN38_10750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN38_10755	COG2323	membrane
ISN38_10765	COG0408	coproporphyrinogen oxidase activity
ISN38_10770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN38_10785	COG1271	oxidase subunit
ISN38_10790	COG1294	oxidase, subunit
ISN38_10815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISN38_10830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISN38_10865	COG0463	Glycosyl transferase, family 2
ISN38_10875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISN38_10880	COG3100	YcgL domain-containing protein
ISN38_10890	COG1404	Belongs to the peptidase S8 family
ISN38_10905	COG0745	RESPONSE REGULATOR receiver
ISN38_10910	COG3387	PFAM Glycoside hydrolase 15-related
ISN38_10915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISN38_10950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ISN38_10955	COG1960	acyl-CoA dehydrogenase activity
ISN38_10970	COG1742	UPF0060 membrane protein
ISN38_10980	COG0523	cobalamin synthesis protein
ISN38_10990	COG0697	spore germination
ISN38_11000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISN38_11005	COG1846	Transcriptional regulator
ISN38_11010	COG1764	response to oxidative stress
ISN38_11025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN38_11030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISN38_11050	COG0583	DNA-binding transcription factor activity
ISN38_11055	COG2814	Major facilitator Superfamily
ISN38_11060	COG1404	Belongs to the peptidase S8 family
ISN38_11085	COG1902	pentaerythritol trinitrate reductase activity
ISN38_11090	COG2084	Dehydrogenase
ISN38_11115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISN38_11160	COG3228	Belongs to the MtfA family
ISN38_11170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISN38_11170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISN38_11175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ISN38_11210	COG0180	Tryptophanyl-tRNA synthetase
ISN38_11245	COG0577	efflux transmembrane transporter activity
ISN38_11250	COG1136	(ABC) transporter
ISN38_11275	COG0753	catalase activity
ISN38_11280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN38_11285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN38_11290	COG0628	permease
ISN38_11310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISN38_11365	COG0823	Involved in the tonB-independent uptake of proteins
ISN38_11365	COG1506	peptidase
ISN38_11385	COG4773	Receptor
ISN38_11405	COG4807	Protein conserved in bacteria
ISN38_11420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISN38_11450	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_11455	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN38_11460	COG4948	Mandelate Racemase Muconate Lactonizing
ISN38_11465	COG3254	rhamnose metabolic process
ISN38_11470	COG0738	Major facilitator superfamily
ISN38_11475	COG1414	Transcriptional regulator
ISN38_11485	COG3052	prosthetic group binding
ISN38_11520	COG1802	Transcriptional regulator
ISN38_11535	COG1595	DNA-templated transcription, initiation
ISN38_11555	COG3321	synthase
ISN38_11555	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_11555	COG0604	alcohol dehydrogenase
ISN38_11560	COG1196	nuclear chromosome segregation
ISN38_11560	COG3264	Mechanosensitive ion channel
ISN38_11585	COG2354	Protein conserved in bacteria
ISN38_11595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISN38_11610	COG0513	Belongs to the DEAD box helicase family
ISN38_11635	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN38_11665	COG3483	tryptophan 2,3-dioxygenase activity
ISN38_11670	COG3104	oligopeptide transport
ISN38_11690	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ISN38_11705	COG0530	calcium, potassium:sodium antiporter activity
ISN38_11710	COG1320	monovalent cation:proton antiporter activity
ISN38_11715	COG2212	antiporter activity
ISN38_11720	COG1863	multisubunit Na H antiporter MnhE subunit
ISN38_11725	COG0651	ATP synthesis coupled electron transport
ISN38_11730	COG1006	Multisubunit Na H antiporter MnhC subunit
ISN38_11735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISN38_11735	COG2111	Na H antiporter
ISN38_11740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN38_11755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISN38_11770	COG1597	lipid kinase activity
ISN38_11790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISN38_11795	COG0134	indole-3-glycerol-phosphate synthase activity
ISN38_11805	COG0730	response to heat
ISN38_11810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISN38_11815	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ISN38_11830	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ISN38_11860	COG2906	2 iron, 2 sulfur cluster binding
ISN38_11900	COG2816	NAD+ diphosphatase activity
ISN38_11940	COG2814	Major facilitator Superfamily
ISN38_11945	COG1289	transmembrane transporter activity
ISN38_11950	COG0151	Belongs to the GarS family
ISN38_11955	COG0138	bifunctional purine biosynthesis protein purh
ISN38_11960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISN38_11965	COG2267	carboxylic ester hydrolase activity
ISN38_11985	COG4589	Belongs to the CDS family
ISN38_11990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISN38_12010	COG2264	protein methyltransferase activity
ISN38_12025	COG0439	Biotin carboxylase
ISN38_12030	COG0511	ligase activity, forming carbon-carbon bonds
ISN38_12035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ISN38_12045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN38_12055	COG1324	tolerance protein
ISN38_12070	COG0459	protein refolding
ISN38_12075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISN38_12095	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ISN38_12110	COG0584	glycerophosphoryl diester phosphodiesterase
ISN38_12140	COG2353	YceI-like domain
ISN38_12155	COG0840	transmembrane signaling receptor activity
ISN38_12195	COG0270	DNA (cytosine-5-)-methyltransferase activity
ISN38_12250	COG5520	Belongs to the glycosyl hydrolase 30 family
ISN38_12275	COG0697	spore germination
ISN38_12280	COG1113	amino acid transport
ISN38_12285	COG0598	Magnesium transport protein CorA
ISN38_12295	COG2207	Transcriptional regulator
ISN38_12310	COG0741	lytic transglycosylase activity
ISN38_12325	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ISN38_12325	COG5297	Belongs to the glycosyl hydrolase family 6
ISN38_12335	COG0531	amino acid
ISN38_12360	COG3275	phosphorelay sensor kinase activity
ISN38_12365	COG3279	Response regulator of the LytR AlgR family
ISN38_12390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISN38_12400	COG2076	Multidrug Resistance protein
ISN38_12410	COG4106	trans-aconitate 2-methyltransferase activity
ISN38_12440	COG5001	Diguanylate cyclase
ISN38_12445	COG2146	nitrite reductase [NAD(P)H] activity
ISN38_12450	COG3706	GGDEF domain
ISN38_12470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISN38_12475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN38_12485	COG0667	Aldo Keto reductase
ISN38_12510	COG3384	dioxygenase
ISN38_12520	COG1573	uracil-dna glycosylase
ISN38_12525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ISN38_12535	COG0025	NhaP-type Na H and K H
ISN38_12540	COG1131	(ABC) transporter
ISN38_12545	COG0842	Transport permease protein
ISN38_12620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN38_12645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISN38_12645	COG2205	protein histidine kinase activity
ISN38_12670	COG1187	pseudouridine synthase activity
ISN38_12680	COG1666	GTP binding
ISN38_12685	COG0697	spore germination
ISN38_12690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISN38_12725	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISN38_12730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISN38_12745	COG0356	it plays a direct role in the translocation of protons across the membrane
ISN38_12755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISN38_12765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISN38_12780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISN38_12795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISN38_12805	COG4191	Histidine kinase
ISN38_12825	COG0577	efflux transmembrane transporter activity
ISN38_12825	COG1136	(ABC) transporter
ISN38_12830	COG0577	efflux transmembrane transporter activity
ISN38_12830	COG1136	(ABC) transporter
ISN38_12835	COG0577	efflux transmembrane transporter activity
ISN38_12835	COG1136	(ABC) transporter
ISN38_12840	COG1136	(ABC) transporter
ISN38_12850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN38_12865	COG2132	Multicopper oxidase
ISN38_12880	COG2217	Heavy metal translocating P-type atpase
ISN38_12895	COG0339	signal peptide processing
ISN38_12915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISN38_12920	COG0546	phosphoglycolate phosphatase activity
ISN38_12925	COG4206	TonB-dependent receptor
ISN38_12935	COG1956	GAF domain-containing protein
ISN38_12940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISN38_12950	COG0720	synthase
ISN38_12955	COG0513	Belongs to the DEAD box helicase family
ISN38_12965	COG0625	glutathione transferase activity
ISN38_12995	COG0626	cystathionine gamma-synthase activity
ISN38_13010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISN38_13015	COG1216	Glycosyl transferase, family 2
ISN38_13015	COG0438	transferase activity, transferring glycosyl groups
ISN38_13020	COG1216	Glycosyl transferase, family 2
ISN38_13020	COG0438	transferase activity, transferring glycosyl groups
ISN38_13060	COG0493	'glutamate synthase
ISN38_13085	COG0300	oxidoreductase activity
ISN38_13090	COG0277	FAD linked oxidase domain protein
ISN38_13095	COG0546	phosphoglycolate phosphatase activity
ISN38_13095	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ISN38_13110	COG2086	electron transfer activity
ISN38_13135	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ISN38_13135	COG0662	Cupin 2, conserved barrel domain protein
ISN38_13140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISN38_13145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISN38_13175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISN38_13175	COG3218	ABC-type transport auxiliary lipoprotein component
ISN38_13180	COG1127	ABC transporter
ISN38_13185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISN38_13200	COG0442	prolyl-tRNA aminoacylation
ISN38_13210	COG1183	phosphatidylcholine synthase activity
ISN38_13245	COG2927	DNA polymerase III (CHI subunit)
ISN38_13250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISN38_13275	COG4974	Belongs to the 'phage' integrase family
ISN38_13280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISN38_13285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISN38_13285	COG0047	phosphoribosylformylglycinamidine synthase activity
ISN38_13290	COG0840	transmembrane signaling receptor activity
ISN38_13300	COG5295	Hep Hag repeat protein
ISN38_13305	COG1404	Belongs to the peptidase S8 family
ISN38_13310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISN38_13315	COG1459	type II secretion system
ISN38_13320	COG2165	general secretion pathway protein
ISN38_13325	COG4970	Tfp pilus assembly protein FimT
ISN38_13330	COG2165	general secretion pathway protein
ISN38_13335	COG4795	General secretion pathway protein
ISN38_13340	COG3156	type II secretion system protein K
ISN38_13345	COG3166	PFAM Fimbrial assembly family protein
ISN38_13360	COG1450	Type ii and iii secretion system protein
ISN38_13370	COG2188	Transcriptional regulator
ISN38_13425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISN38_13435	COG1215	transferase activity, transferring glycosyl groups
ISN38_13465	COG0242	peptide deformylase activity
ISN38_13470	COG0488	(ABC) transporter
ISN38_13475	COG0477	Major facilitator Superfamily
ISN38_13505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISN38_13515	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN38_13515	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISN38_13530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISN38_13535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISN38_13540	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISN38_13565	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ISN38_13570	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ISN38_13580	COG2205	protein histidine kinase activity
ISN38_13585	COG0745	RESPONSE REGULATOR receiver
ISN38_13590	COG0277	FAD linked oxidase domain protein
ISN38_13600	COG0792	nuclease activity
ISN38_13635	COG2001	Belongs to the MraZ family
ISN38_13640	COG0275	rRNA processing
ISN38_13645	COG3116	cell division
ISN38_13660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISN38_13675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISN38_13685	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISN38_13690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISN38_13700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISN38_13705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ISN38_13715	COG0739	heme binding
ISN38_13730	COG0494	nUDIX hydrolase
ISN38_13740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISN38_13765	COG2226	methyltransferase
ISN38_13805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISN38_13820	COG1090	epimerase
ISN38_13830	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ISN38_13835	COG0673	inositol 2-dehydrogenase activity
ISN38_13840	COG2823	Periplasmic or secreted lipoprotein
ISN38_13850	COG2205	protein histidine kinase activity
ISN38_13850	COG2202	Pas domain
ISN38_13855	COG0784	Response regulator, receiver
ISN38_13860	COG4191	Histidine kinase
ISN38_13870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISN38_13900	COG3250	beta-galactosidase activity
ISN38_13915	COG2188	Transcriptional regulator
ISN38_13920	COG0738	Major facilitator superfamily
ISN38_13925	COG1609	Transcriptional regulator
ISN38_13930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ISN38_13935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISN38_13940	COG0617	tRNA 3'-terminal CCA addition
ISN38_14020	COG2205	protein histidine kinase activity
ISN38_14035	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ISN38_14040	COG3791	Glutathione-dependent formaldehyde-activating
ISN38_14085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ISN38_14105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN38_14130	COG0436	Aminotransferase
ISN38_14135	COG1162	GTPase activity
ISN38_14160	COG2211	Major facilitator Superfamily
ISN38_14170	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_14175	COG2851	Citrate transporter
ISN38_14190	COG0642	Histidine kinase
ISN38_14210	COG4191	Histidine kinase
ISN38_14220	COG1301	dicarboxylic acid transport
ISN38_14225	COG0281	malic enzyme
ISN38_14225	COG0280	phosphate acetyltransferase
ISN38_14300	COG1560	Kdo2-lipid A biosynthetic process
ISN38_14305	COG1519	Transferase
ISN38_14310	COG1538	Outer membrane efflux protein
ISN38_14315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ISN38_14325	COG3706	GGDEF domain
ISN38_14330	COG0473	3-isopropylmalate dehydrogenase activity
ISN38_14335	COG0066	3-isopropylmalate dehydratase activity
ISN38_14345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISN38_14355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISN38_14375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISN38_14380	COG0840	transmembrane signaling receptor activity
ISN38_14400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISN38_14410	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ISN38_14430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISN38_14440	COG0671	phosphoesterase, PA-phosphatase related
ISN38_14455	COG1940	carbohydrate kinase activity
ISN38_14465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISN38_14505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISN38_14520	COG1773	rubredoxin
ISN38_14535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISN38_14545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISN38_14570	COG3079	Belongs to the UPF0149 family
ISN38_14575	COG0006	proline dipeptidase activity
ISN38_14595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISN38_14625	COG0714	Associated with various cellular activities
ISN38_14655	COG1301	dicarboxylic acid transport
ISN38_14660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISN38_14685	COG0739	heme binding
ISN38_14690	COG1376	ErfK ybiS ycfS ynhG family protein
ISN38_14715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ISN38_14720	COG4149	molybdate abc transporter
ISN38_14725	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISN38_14735	COG0640	Transcriptional regulator
ISN38_14755	COG3047	cAMP biosynthetic process
ISN38_14760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISN38_14805	COG0469	pyruvate kinase activity
ISN38_14810	COG3588	fructose-bisphosphate aldolase
ISN38_14815	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ISN38_14855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN38_14870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ISN38_14870	COG1648	precorrin-2 dehydrogenase activity
ISN38_14885	COG2198	Histidine kinase
ISN38_14885	COG2205	protein histidine kinase activity
ISN38_14885	COG0784	Response regulator, receiver
ISN38_14890	COG1393	Belongs to the ArsC family
ISN38_14920	COG0175	sulfate reduction
ISN38_14925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISN38_14930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN38_14940	COG2895	sulfate adenylyltransferase (ATP) activity
ISN38_14940	COG0529	Catalyzes the synthesis of activated sulfate
ISN38_14945	COG0840	transmembrane signaling receptor activity
ISN38_14965	COG1115	amino acid carrier protein
ISN38_14980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN38_15000	COG1609	Transcriptional regulator
ISN38_15015	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISN38_15030	COG0471	metal ion transport
ISN38_15030	COG3273	potassium ion transport
ISN38_15040	COG2022	thiamine diphosphate biosynthetic process
ISN38_15065	COG0174	glutamine synthetase
ISN38_15070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ISN38_15080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN38_15095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISN38_15120	COG3511	phospholipase C
ISN38_15130	COG0189	ligase activity
ISN38_15140	COG0745	RESPONSE REGULATOR receiver
ISN38_15155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ISN38_15225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISN38_15225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISN38_15235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISN38_15255	COG1174	glycine betaine transport
ISN38_15260	COG1125	glycine betaine transport
ISN38_15270	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISN38_15275	COG0564	pseudouridine synthase activity
ISN38_15295	COG4993	Dehydrogenase
ISN38_15310	COG3387	PFAM Glycoside hydrolase 15-related
ISN38_15360	COG0542	response to heat
ISN38_15385	COG0019	diaminopimelate decarboxylase activity
ISN38_15390	COG4264	IucA IucC family
ISN38_15395	COG2814	Major facilitator Superfamily
ISN38_15400	COG4264	IucA IucC family
ISN38_15410	COG4772	TonB-dependent receptor
ISN38_15420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISN38_15420	COG4651	solute:proton antiporter activity
ISN38_15475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN38_15475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISN38_15535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISN38_15540	COG1404	Belongs to the peptidase S8 family
ISN38_15550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISN38_15570	COG1295	ribonuclease BN
ISN38_15575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISN38_15595	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISN38_15685	COG3209	COG3209 Rhs family protein
ISN38_15695	COG3209	COG3209 Rhs family protein
ISN38_15740	COG4682	membrane
ISN38_15830	COG3179	chitinase
ISN38_16000	COG3537	Alpha-1,2-mannosidase
ISN38_16020	COG1472	Belongs to the glycosyl hydrolase 3 family
ISN38_16030	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ISN38_16035	COG3858	chitin binding
ISN38_16035	COG1388	LysM domain
ISN38_16050	COG0837	glucose binding
ISN38_16060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISN38_16070	COG0494	nUDIX hydrolase
ISN38_16075	COG1218	3'(2'),5'-bisphosphate nucleotidase
ISN38_16080	COG3956	TIGRFAM MazG family protein
ISN38_16085	COG1742	UPF0060 membrane protein
ISN38_16095	COG0330	HflC and HflK could
ISN38_16165	COG2124	cytochrome p450
ISN38_16170	COG2124	cytochrome p450
ISN38_16175	COG1141	Ferredoxin
ISN38_16180	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_16185	COG2124	cytochrome p450
ISN38_16190	COG0142	geranyltranstransferase activity
ISN38_16195	COG1657	PFAM Prenyltransferase squalene oxidase
ISN38_16205	COG1304	FMN binding
ISN38_16250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISN38_16255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISN38_16260	COG0463	Glycosyl transferase, family 2
ISN38_16265	COG0517	IMP dehydrogenase activity
ISN38_16270	COG2982	Protein involved in outer membrane biogenesis
ISN38_16275	COG1272	protein, Hemolysin III
ISN38_16280	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISN38_16290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISN38_16295	COG0626	cystathionine gamma-synthase activity
ISN38_16300	COG0527	aspartate kinase activity
ISN38_16300	COG0460	homoserine dehydrogenase
ISN38_16305	COG2267	carboxylic ester hydrolase activity
ISN38_16315	COG1760	l-serine dehydratase
ISN38_16330	COG3038	cytochrome b561
ISN38_16350	COG2814	Major facilitator Superfamily
ISN38_16355	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISN38_16365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISN38_16385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISN38_16390	COG0259	pyridoxamine-phosphate oxidase activity
ISN38_16430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISN38_16445	COG0519	Catalyzes the synthesis of GMP from XMP
ISN38_16460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISN38_16485	COG0840	transmembrane signaling receptor activity
ISN38_16495	COG1113	amino acid transport
ISN38_16515	COG2239	Acts as a magnesium transporter
ISN38_16520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN38_16525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN38_16535	COG1660	Displays ATPase and GTPase activities
ISN38_16545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN38_16560	COG1137	ATPase activity
ISN38_16575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISN38_16620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISN38_16645	COG0628	permease
ISN38_16655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ISN38_16660	COG3178	'Phosphotransferase
ISN38_16675	COG1555	photosystem II stabilization
ISN38_16695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISN38_16700	COG1477	protein flavinylation
ISN38_16725	COG4774	siderophore transport
ISN38_16730	COG2146	nitrite reductase [NAD(P)H] activity
ISN38_16740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISN38_16745	COG0719	Fe-S assembly protein
ISN38_16750	COG0396	ATPase activity
ISN38_16755	COG0719	Fe-S assembly protein
ISN38_16770	COG0693	protein deglycase activity
ISN38_16785	COG0739	heme binding
ISN38_16800	COG1764	response to oxidative stress
ISN38_16810	COG0384	phenazine biosynthesis protein PhzF
ISN38_16815	COG0527	aspartate kinase activity
ISN38_16840	COG0142	geranyltranstransferase activity
ISN38_16845	COG0629	single-stranded DNA binding
ISN38_16865	COG3104	oligopeptide transport
ISN38_16870	COG1297	OPT oligopeptide transporter protein
ISN38_16875	COG1506	peptidase
ISN38_16875	COG0823	Involved in the tonB-independent uptake of proteins
ISN38_16895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISN38_16900	COG2879	small protein
ISN38_16905	COG1966	Carbon starvation protein
ISN38_16940	COG2211	Major facilitator Superfamily
ISN38_16950	COG2801	Transposase and inactivated derivatives
ISN38_16975	COG0835	chemotaxis
ISN38_16980	COG0840	transmembrane signaling receptor activity
ISN38_16985	COG0840	transmembrane signaling receptor activity
ISN38_16990	COG0840	transmembrane signaling receptor activity
ISN38_16995	COG0643	Histidine kinase
ISN38_16995	COG2198	Histidine kinase
ISN38_17005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISN38_17025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISN38_17035	COG2205	protein histidine kinase activity
ISN38_17070	COG0735	belongs to the Fur family
ISN38_17110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ISN38_17115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ISN38_17120	COG2080	2 iron, 2 sulfur cluster binding
ISN38_17235	COG1187	pseudouridine synthase activity
ISN38_17260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISN38_17280	COG1132	(ABC) transporter
ISN38_17385	COG1981	membrane
ISN38_17410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN38_17415	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN38_17425	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISN38_17435	COG0750	zinc metalloprotease
ISN38_17440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ISN38_17445	COG0575	Belongs to the CDS family
ISN38_17450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISN38_17460	COG0528	UMP kinase activity
ISN38_17470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISN38_17510	COG0024	Methionine aminopeptidase
ISN38_17525	COG1393	Belongs to the ArsC family
ISN38_17535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISN38_17545	COG0367	asparagine synthase
ISN38_17585	COG1566	PFAM secretion protein HlyD family protein
ISN38_17590	COG2814	Major facilitator Superfamily
ISN38_17625	COG0557	exoribonuclease II activity
ISN38_17635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISN38_17655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISN38_17680	COG0704	Plays a role in the regulation of phosphate uptake
ISN38_17690	COG0581	inorganic phosphate transmembrane transporter activity
ISN38_17700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN38_17705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISN38_17725	COG0659	secondary active sulfate transmembrane transporter activity
ISN38_17730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISN38_17740	COG1024	Enoyl-CoA hydratase
ISN38_17800	COG0784	Response regulator, receiver
ISN38_17800	COG2205	protein histidine kinase activity
ISN38_17800	COG5002	protein histidine kinase activity
ISN38_17805	COG2733	membrane
ISN38_17825	COG0686	Belongs to the AlaDH PNT family
ISN38_17830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ISN38_17835	COG1396	sequence-specific DNA binding
ISN38_17835	COG1917	Cupin 2, conserved barrel domain protein
ISN38_17840	COG1012	belongs to the aldehyde dehydrogenase family
ISN38_17860	COG2223	nitrite transmembrane transporter activity
ISN38_17870	COG0243	molybdopterin cofactor binding
ISN38_17885	COG0477	Major facilitator Superfamily
ISN38_17895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISN38_17900	COG0174	glutamine synthetase
ISN38_17905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ISN38_17910	COG0174	glutamine synthetase
ISN38_17950	COG3842	ATPase activity
ISN38_17955	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISN38_17960	COG1177	transmembrane transport
ISN38_17965	COG1012	belongs to the aldehyde dehydrogenase family
ISN38_17980	COG4535	Mg2 and Co2 transporter CorC
ISN38_17995	COG1702	phosphate starvation-inducible protein PhoH
ISN38_18010	COG0741	lytic transglycosylase activity
ISN38_18015	COG0723	plastoquinol--plastocyanin reductase activity
ISN38_18020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ISN38_18030	COG2857	Cytochrome c1
ISN38_18035	COG0625	glutathione transferase activity
ISN38_18040	COG2969	positive regulation of protein catabolic process
ISN38_18080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISN38_18085	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_18090	COG2095	MarC family integral membrane protein
ISN38_18100	COG1611	Belongs to the LOG family
ISN38_18105	COG3275	phosphorelay sensor kinase activity
ISN38_18205	COG2925	Exonuclease
ISN38_18215	COG3844	kynureninase activity
ISN38_18230	COG0288	reversible hydration of carbon dioxide
ISN38_18275	COG2197	response regulator
ISN38_18300	COG0316	Belongs to the HesB IscA family
ISN38_18335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISN38_18340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISN38_18345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ISN38_18355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ISN38_18380	COG1309	transcriptional regulator
ISN38_18395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISN38_18410	COG1228	amidohydrolase
ISN38_18425	COG4221	oxidoreductase activity
ISN38_18465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISN38_18470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ISN38_18475	COG1605	Chorismate mutase
ISN38_18475	COG0077	Prephenate dehydratase
ISN38_18500	COG0583	DNA-binding transcription factor activity
ISN38_18535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ISN38_18580	COG2963	transposase activity
ISN38_18635	COG0577	efflux transmembrane transporter activity
ISN38_18635	COG1136	(ABC) transporter
ISN38_18670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN38_18670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISN38_18675	COG1105	Belongs to the carbohydrate kinase PfkB family
ISN38_18680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISN38_18680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISN38_18685	COG1609	Transcriptional regulator
ISN38_18695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISN38_18700	COG0069	glutamate synthase activity
ISN38_18735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISN38_18750	COG1253	flavin adenine dinucleotide binding
ISN38_18760	COG0306	phosphate transporter
ISN38_18780	COG0504	CTP synthase activity
ISN38_18800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISN38_18805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ISN38_18820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ISN38_18830	COG1238	metal cluster binding
ISN38_18845	COG1534	Rna-binding protein
ISN38_18850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ISN38_18855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISN38_18860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISN38_18865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISN38_18875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISN38_18880	COG1546	Belongs to the CinA family
ISN38_18885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ISN38_18890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISN38_18895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISN38_18900	COG2137	regulation of response to DNA damage stimulus
ISN38_18910	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISN38_18935	COG1741	Belongs to the pirin family
ISN38_18940	COG0583	DNA-binding transcription factor activity
ISN38_18960	COG0351	phosphomethylpyrimidine kinase
ISN38_18960	COG0352	thiamine-phosphate diphosphorylase activity
ISN38_19000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ISN38_19005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISN38_19015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISN38_19025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ISN38_19030	COG3734	2-keto-3-deoxy-galactonokinase
ISN38_19045	COG0800	Aldolase
ISN38_19080	COG2205	protein histidine kinase activity
ISN38_19080	COG2198	Histidine kinase
ISN38_19080	COG0784	Response regulator, receiver
ISN38_19085	COG1024	Enoyl-CoA hydratase
ISN38_19090	COG0318	PFAM AMP-dependent synthetase and ligase
ISN38_19150	COG0840	transmembrane signaling receptor activity
ISN38_19160	COG0840	transmembrane signaling receptor activity
ISN38_19170	COG0835	chemotaxis
ISN38_19180	COG0840	transmembrane signaling receptor activity
ISN38_19190	COG0840	transmembrane signaling receptor activity
ISN38_19195	COG0840	transmembrane signaling receptor activity
ISN38_19200	COG0840	transmembrane signaling receptor activity
ISN38_19210	COG0840	transmembrane signaling receptor activity
ISN38_19220	COG0840	transmembrane signaling receptor activity
ISN38_19225	COG0840	transmembrane signaling receptor activity
ISN38_19230	COG0840	transmembrane signaling receptor activity
ISN38_19235	COG0840	transmembrane signaling receptor activity
ISN38_19245	COG0745	RESPONSE REGULATOR receiver
ISN38_19255	COG0835	chemotaxis
ISN38_19260	COG1192	Involved in chromosome partitioning
ISN38_19270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISN38_19275	COG0784	Response regulator, receiver
ISN38_19275	COG2198	Histidine kinase
ISN38_19275	COG0643	Histidine kinase
ISN38_19280	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISN38_19325	COG1684	flagellar biosynthetic protein fliR
ISN38_19330	COG1987	bacterial-type flagellum assembly
ISN38_19340	COG3190	flagellar
ISN38_19390	COG1677	Flagellar hook-basal body complex protein FliE
ISN38_19425	COG1028	Short-chain dehydrogenase reductase Sdr
ISN38_19435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISN38_19455	COG2201	protein-glutamate methylesterase activity
ISN38_19465	COG2197	response regulator
ISN38_19485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISN38_19490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ISN38_19500	COG1256	bacterial-type flagellum assembly
ISN38_19500	COG4786	Flagellar basal body rod
ISN38_19500	COG1256	bacterial-type flagellum assembly
ISN38_19500	COG4786	Flagellar basal body rod
ISN38_19515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ISN38_19645	COG4962	Type ii secretion system protein e
ISN38_19655	COG5268	conjugation
ISN38_19660	COG3451	type IV secretory pathway VirB4
ISN38_19775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISN38_19805	COG2948	multi-organism process
ISN38_19815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISN38_19890	COG0629	single-stranded DNA binding