locus-tag	class	description
MZO50_00115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MZO50_00220	COG5268	conjugation
MZO50_00365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MZO50_00480	COG5268	conjugation
MZO50_00490	COG4962	Type ii secretion system protein e
MZO50_00495	COG4962	Type ii secretion system protein e
MZO50_00525	COG4191	Histidine kinase
MZO50_00530	COG0028	Belongs to the TPP enzyme family
MZO50_00545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MZO50_00560	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZO50_00570	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_00580	COG3685	Protein conserved in bacteria
MZO50_00585	COG3685	Protein conserved in bacteria
MZO50_00590	COG3546	catalase activity
MZO50_00605	COG0840	transmembrane signaling receptor activity
MZO50_00650	COG1309	transcriptional regulator
MZO50_00700	COG0366	Alpha amylase catalytic
MZO50_00705	COG0366	Alpha amylase catalytic
MZO50_00715	COG1609	Transcriptional regulator
MZO50_00750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MZO50_00755	COG1490	D-aminoacyl-tRNA deacylase activity
MZO50_00765	COG1247	-acetyltransferase
MZO50_00770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MZO50_00805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MZO50_00810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MZO50_00810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MZO50_00815	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MZO50_00820	COG0242	peptide deformylase activity
MZO50_00825	COG1652	LysM domain
MZO50_00830	COG0758	DNA mediated transformation
MZO50_00850	COG1714	RDD family
MZO50_00855	COG1754	DNA topoisomerase type I activity
MZO50_00855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MZO50_00860	COG0009	L-threonylcarbamoyladenylate synthase
MZO50_00880	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_00890	COG0616	signal peptide processing
MZO50_00895	COG0534	Mate efflux family protein
MZO50_00905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MZO50_00915	COG1252	NADH dehydrogenase
MZO50_00925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MZO50_00930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MZO50_00935	COG2201	protein-glutamate methylesterase activity
MZO50_00940	COG2177	Part of the ABC transporter FtsEX involved in
MZO50_00945	COG2884	Cell division ATP-binding protein ftsE
MZO50_00955	COG3118	belongs to the thioredoxin family
MZO50_00960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MZO50_00980	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
MZO50_01025	COG1518	maintenance of DNA repeat elements
MZO50_01030	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
MZO50_01040	COG1652	LysM domain
MZO50_01055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO50_01060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MZO50_01075	COG5383	Protein conserved in bacteria
MZO50_01125	COG3023	N-Acetylmuramoyl-L-alanine amidase
MZO50_01130	COG4771	TonB-dependent receptor
MZO50_01140	COG4948	Mandelate Racemase Muconate Lactonizing
MZO50_01150	COG0531	amino acid
MZO50_01170	COG2133	pyrroloquinoline quinone binding
MZO50_01185	COG2308	Evidence 4 Homologs of previously reported genes of
MZO50_01190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MZO50_01210	COG1295	ribonuclease BN
MZO50_01215	COG0358	DNA primase activity
MZO50_01230	COG0109	protoheme IX farnesyltransferase activity
MZO50_01260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MZO50_01265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MZO50_01290	COG0531	amino acid
MZO50_01320	COG0793	Belongs to the peptidase S41A family
MZO50_01325	COG4942	peptidase
MZO50_01335	COG2234	aminopeptidase activity
MZO50_01340	COG1064	alcohol dehydrogenase
MZO50_01370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MZO50_01375	COG0739	heme binding
MZO50_01390	COG2814	Major facilitator Superfamily
MZO50_01400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MZO50_01420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MZO50_01440	COG4221	oxidoreductase activity
MZO50_01460	COG0583	DNA-binding transcription factor activity
MZO50_01465	COG2755	lipolytic protein G-D-S-L family
MZO50_01465	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MZO50_01470	COG1819	glycosyl
MZO50_01475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MZO50_01485	COG1166	arginine decarboxylase activity
MZO50_01515	COG2960	long-chain fatty acid transporting porin activity
MZO50_01520	COG0606	chelatase, subunit chli
MZO50_01550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MZO50_01560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MZO50_01575	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_01595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MZO50_01620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MZO50_01625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO50_01640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MZO50_01685	COG0714	Associated with various cellular activities
MZO50_01695	COG0754	glutathionylspermidine amidase activity
MZO50_01735	COG2133	pyrroloquinoline quinone binding
MZO50_01745	COG0628	permease
MZO50_01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MZO50_01835	COG1199	ATP-dependent helicase activity
MZO50_01910	COG0625	glutathione transferase activity
MZO50_01930	COG4555	ABC transporter
MZO50_01940	COG1476	TRANSCRIPTIONal
MZO50_01950	COG0543	2 iron, 2 sulfur cluster binding
MZO50_01950	COG0633	Ferredoxin
MZO50_01955	COG1131	(ABC) transporter
MZO50_01960	COG0842	Transport permease protein
MZO50_01975	COG0084	hydrolase, TatD family'
MZO50_01980	COG1643	Atp-dependent helicase
MZO50_01990	COG1187	pseudouridine synthase activity
MZO50_02005	COG2130	NADP-dependent
MZO50_02010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MZO50_02045	COG0659	secondary active sulfate transmembrane transporter activity
MZO50_02080	COG2224	Isocitrate lyase
MZO50_02085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MZO50_02090	COG0583	DNA-binding transcription factor activity
MZO50_02110	COG0339	signal peptide processing
MZO50_02130	COG0564	pseudouridine synthase activity
MZO50_02135	COG4232	protein-disulfide reductase activity
MZO50_02150	COG1181	Belongs to the D-alanine--D-alanine ligase family
MZO50_02160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MZO50_02180	COG0318	PFAM AMP-dependent synthetase and ligase
MZO50_02185	COG0727	PFAM Uncharacterised protein family (UPF0153)
MZO50_02195	COG0596	Alpha beta hydrolase
MZO50_02205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MZO50_02215	COG0612	Peptidase, M16
MZO50_02225	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MZO50_02235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MZO50_02240	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
MZO50_02280	COG0183	Belongs to the thiolase family
MZO50_02290	COG2032	superoxide dismutase activity
MZO50_02295	COG2032	superoxide dismutase activity
MZO50_02300	COG2204	response regulator
MZO50_02305	COG3852	Histidine kinase
MZO50_02310	COG0004	ammonium transporteR
MZO50_02315	COG0347	Belongs to the P(II) protein family
MZO50_02320	COG0174	glutamine synthetase
MZO50_02325	COG1968	undecaprenyl-diphosphatase activity
MZO50_02330	COG1881	PFAM PEBP family protein
MZO50_02345	COG2267	carboxylic ester hydrolase activity
MZO50_02355	COG2050	protein possibly involved in aromatic compounds catabolism
MZO50_02360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MZO50_02370	COG2062	phosphohistidine phosphatase, SixA
MZO50_02375	COG1192	Involved in chromosome partitioning
MZO50_02425	COG2271	Major facilitator Superfamily
MZO50_02460	COG1111	helicase
MZO50_02460	COG1205	dead DEAH box helicase
MZO50_02505	COG0067	glutamate synthase
MZO50_02505	COG0070	glutamate synthase
MZO50_02505	COG0069	glutamate synthase activity
MZO50_02510	COG0493	'glutamate synthase
MZO50_02515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MZO50_02520	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MZO50_02525	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MZO50_02595	COG2951	lytic endotransglycosylase activity
MZO50_02610	COG0730	response to heat
MZO50_02635	COG0302	gtp cyclohydrolase
MZO50_02640	COG0477	Major facilitator Superfamily
MZO50_02710	COG0537	adenosine 5'-monophosphoramidase activity
MZO50_02730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MZO50_02735	COG1074	ATP-dependent DNA helicase activity
MZO50_02740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MZO50_02745	COG1127	ABC transporter
MZO50_02750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MZO50_02755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MZO50_02770	COG2853	Lipoprotein
MZO50_02775	COG0386	Belongs to the glutathione peroxidase family
MZO50_02780	COG1322	Protein conserved in bacteria
MZO50_02800	COG4191	Histidine kinase
MZO50_02805	COG4566	intracellular signal transduction
MZO50_02810	COG0531	amino acid
MZO50_02820	COG1929	Belongs to the glycerate kinase type-1 family
MZO50_02855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MZO50_02870	COG0671	phosphoesterase, PA-phosphatase related
MZO50_02885	COG1473	amidohydrolase
MZO50_02890	COG1473	amidohydrolase
MZO50_02895	COG1752	Esterase of the alpha-beta hydrolase superfamily
MZO50_02915	COG1522	sequence-specific DNA binding
MZO50_02920	COG3186	Phenylalanine-4-hydroxylase
MZO50_02935	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_02945	COG1609	Transcriptional regulator
MZO50_02950	COG3507	Belongs to the glycosyl hydrolase 43 family
MZO50_02965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MZO50_03010	COG4771	TonB-dependent receptor
MZO50_03030	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MZO50_03115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MZO50_03150	COG1304	FMN binding
MZO50_03185	COG1012	belongs to the aldehyde dehydrogenase family
MZO50_03190	COG3284	Transcriptional regulator
MZO50_03200	COG4772	TonB-dependent receptor
MZO50_03215	COG1280	lysine exporter protein (LysE YggA)
MZO50_03230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MZO50_03270	COG0501	Belongs to the peptidase M48B family
MZO50_03275	COG1266	CAAX protease self-immunity
MZO50_03280	COG0187	DNA topoisomerase II activity
MZO50_03285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MZO50_03305	COG0594	ribonuclease P activity
MZO50_03310	COG0706	membrane insertase activity
MZO50_03330	COG1119	ATPase activity
MZO50_03345	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MZO50_03370	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
MZO50_03380	COG1435	thymidine kinase activity
MZO50_03385	COG0210	DNA helicase
MZO50_03405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MZO50_03410	COG0519	Catalyzes the synthesis of GMP from XMP
MZO50_03410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MZO50_03420	COG0805	protein transport
MZO50_03430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MZO50_03440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MZO50_03460	COG0037	tRNA processing
MZO50_03465	COG2115	Belongs to the xylose isomerase family
MZO50_03475	COG3661	Belongs to the glycosyl hydrolase 67 family
MZO50_03485	COG4948	Mandelate Racemase Muconate Lactonizing
MZO50_03500	COG0246	Mannitol dehydrogenase
MZO50_03515	COG3046	protein related to deoxyribodipyrimidine photolyase
MZO50_03540	COG3386	PFAM SMP-30 Gluconolaconase
MZO50_03560	COG3693	PFAM glycoside hydrolase, family 10
MZO50_03575	COG2211	Major facilitator Superfamily
MZO50_03600	COG2937	Belongs to the GPAT DAPAT family
MZO50_03610	COG1609	Transcriptional regulator
MZO50_03625	COG0284	orotidine-5'-phosphate decarboxylase activity
MZO50_03685	COG3132	Protein of unknown function, DUF480
MZO50_03705	COG0729	surface antigen
MZO50_03710	COG2911	Protein conserved in bacteria
MZO50_03730	COG3265	gluconokinase activity
MZO50_03735	COG2211	Major facilitator Superfamily
MZO50_03740	COG3459	Glycosyltransferase 36 associated
MZO50_03745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZO50_03750	COG2205	protein histidine kinase activity
MZO50_03755	COG1971	Probably functions as a manganese efflux pump
MZO50_03775	COG0477	Major facilitator Superfamily
MZO50_03800	COG2091	lysine biosynthetic process via aminoadipic acid
MZO50_03815	COG0357	Ribosomal RNA small subunit methyltransferase G
MZO50_03820	COG1192	Involved in chromosome partitioning
MZO50_03825	COG1475	DNA binding
MZO50_03835	COG0463	Glycosyl transferase, family 2
MZO50_03885	COG0210	DNA helicase
MZO50_03905	COG0589	response to stress
MZO50_03925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MZO50_03925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MZO50_03930	COG2323	membrane
MZO50_03940	COG0408	coproporphyrinogen oxidase activity
MZO50_03945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MZO50_03960	COG1271	oxidase subunit
MZO50_03965	COG1294	oxidase, subunit
MZO50_03990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MZO50_04005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MZO50_04040	COG0463	Glycosyl transferase, family 2
MZO50_04050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MZO50_04055	COG3100	YcgL domain-containing protein
MZO50_04065	COG1404	Belongs to the peptidase S8 family
MZO50_04095	COG0745	RESPONSE REGULATOR receiver
MZO50_04100	COG3387	PFAM Glycoside hydrolase 15-related
MZO50_04105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MZO50_04135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MZO50_04140	COG1960	acyl-CoA dehydrogenase activity
MZO50_04160	COG1742	UPF0060 membrane protein
MZO50_04170	COG0523	cobalamin synthesis protein
MZO50_04235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MZO50_04255	COG0628	permease
MZO50_04260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MZO50_04265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MZO50_04295	COG1136	(ABC) transporter
MZO50_04300	COG0577	efflux transmembrane transporter activity
MZO50_04320	COG0697	spore germination
MZO50_04335	COG0180	Tryptophanyl-tRNA synthetase
MZO50_04370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MZO50_04375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MZO50_04375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MZO50_04385	COG3228	Belongs to the MtfA family
MZO50_04420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MZO50_04445	COG2084	Dehydrogenase
MZO50_04450	COG1902	pentaerythritol trinitrate reductase activity
MZO50_04475	COG1404	Belongs to the peptidase S8 family
MZO50_04480	COG2814	Major facilitator Superfamily
MZO50_04485	COG0583	DNA-binding transcription factor activity
MZO50_04505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MZO50_04510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MZO50_04520	COG1764	response to oxidative stress
MZO50_04525	COG1846	Transcriptional regulator
MZO50_04530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MZO50_04540	COG0697	spore germination
MZO50_04555	COG0823	Involved in the tonB-independent uptake of proteins
MZO50_04555	COG1506	peptidase
MZO50_04595	COG4807	Protein conserved in bacteria
MZO50_04610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MZO50_04645	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_04650	COG0179	Fumarylacetoacetate (FAA) hydrolase
MZO50_04655	COG4948	Mandelate Racemase Muconate Lactonizing
MZO50_04660	COG3254	rhamnose metabolic process
MZO50_04665	COG0738	Major facilitator superfamily
MZO50_04670	COG1414	Transcriptional regulator
MZO50_04680	COG3052	prosthetic group binding
MZO50_04715	COG1802	Transcriptional regulator
MZO50_04735	COG1595	DNA-templated transcription, initiation
MZO50_04755	COG0604	alcohol dehydrogenase
MZO50_04755	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_04755	COG3321	synthase
MZO50_04760	COG1196	nuclear chromosome segregation
MZO50_04760	COG3264	Mechanosensitive ion channel
MZO50_04780	COG2354	Protein conserved in bacteria
MZO50_04790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MZO50_04805	COG0513	Belongs to the DEAD box helicase family
MZO50_04830	COG0508	dehydrogenase complex catalyzes the overall conversion of
MZO50_04845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MZO50_04860	COG3483	tryptophan 2,3-dioxygenase activity
MZO50_04865	COG3104	oligopeptide transport
MZO50_04885	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MZO50_04900	COG0530	calcium, potassium:sodium antiporter activity
MZO50_04905	COG1320	monovalent cation:proton antiporter activity
MZO50_04910	COG2212	antiporter activity
MZO50_04915	COG1863	multisubunit Na H antiporter MnhE subunit
MZO50_04920	COG0651	ATP synthesis coupled electron transport
MZO50_04925	COG1006	Multisubunit Na H antiporter MnhC subunit
MZO50_04930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MZO50_04930	COG2111	Na H antiporter
MZO50_04935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MZO50_04950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MZO50_04965	COG1597	lipid kinase activity
MZO50_04985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MZO50_04990	COG0134	indole-3-glycerol-phosphate synthase activity
MZO50_05005	COG0730	response to heat
MZO50_05010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MZO50_05015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MZO50_05030	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
MZO50_05060	COG2906	2 iron, 2 sulfur cluster binding
MZO50_05100	COG2816	NAD+ diphosphatase activity
MZO50_05140	COG2814	Major facilitator Superfamily
MZO50_05145	COG1289	transmembrane transporter activity
MZO50_05150	COG0151	Belongs to the GarS family
MZO50_05155	COG0138	bifunctional purine biosynthesis protein purh
MZO50_05160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MZO50_05185	COG4589	Belongs to the CDS family
MZO50_05195	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MZO50_05215	COG2264	protein methyltransferase activity
MZO50_05230	COG0439	Biotin carboxylase
MZO50_05235	COG0511	ligase activity, forming carbon-carbon bonds
MZO50_05240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MZO50_05250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MZO50_05260	COG1324	tolerance protein
MZO50_05275	COG0459	protein refolding
MZO50_05280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MZO50_05300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MZO50_05315	COG0584	glycerophosphoryl diester phosphodiesterase
MZO50_05345	COG2353	YceI-like domain
MZO50_05360	COG0840	transmembrane signaling receptor activity
MZO50_05400	COG0270	DNA (cytosine-5-)-methyltransferase activity
MZO50_05475	COG5520	Belongs to the glycosyl hydrolase 30 family
MZO50_05505	COG0697	spore germination
MZO50_05510	COG1113	amino acid transport
MZO50_05515	COG0598	Magnesium transport protein CorA
MZO50_05525	COG2207	Transcriptional regulator
MZO50_05545	COG0741	lytic transglycosylase activity
MZO50_05560	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MZO50_05560	COG5297	Belongs to the glycosyl hydrolase family 6
MZO50_05570	COG0531	amino acid
MZO50_05595	COG3275	phosphorelay sensor kinase activity
MZO50_05600	COG3279	Response regulator of the LytR AlgR family
MZO50_05620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MZO50_05630	COG2076	Multidrug Resistance protein
MZO50_05640	COG4106	trans-aconitate 2-methyltransferase activity
MZO50_05670	COG5001	Diguanylate cyclase
MZO50_05685	COG3706	GGDEF domain
MZO50_05705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MZO50_05710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MZO50_05720	COG0667	Aldo Keto reductase
MZO50_05725	COG0667	Aldo Keto reductase
MZO50_05745	COG3384	dioxygenase
MZO50_05755	COG1573	uracil-dna glycosylase
MZO50_05760	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MZO50_05770	COG0025	NhaP-type Na H and K H
MZO50_05775	COG1131	(ABC) transporter
MZO50_05780	COG0842	Transport permease protein
MZO50_05855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MZO50_05880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MZO50_05880	COG2205	protein histidine kinase activity
MZO50_05905	COG1187	pseudouridine synthase activity
MZO50_05915	COG1666	GTP binding
MZO50_05920	COG0697	spore germination
MZO50_05925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MZO50_05960	COG0508	dehydrogenase complex catalyzes the overall conversion of
MZO50_05965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MZO50_05980	COG0356	it plays a direct role in the translocation of protons across the membrane
MZO50_05990	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MZO50_06000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MZO50_06015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MZO50_06030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MZO50_06060	COG0577	efflux transmembrane transporter activity
MZO50_06060	COG1136	(ABC) transporter
MZO50_06065	COG0577	efflux transmembrane transporter activity
MZO50_06065	COG1136	(ABC) transporter
MZO50_06070	COG0577	efflux transmembrane transporter activity
MZO50_06070	COG1136	(ABC) transporter
MZO50_06075	COG1136	(ABC) transporter
MZO50_06085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MZO50_06100	COG2132	Multicopper oxidase
MZO50_06115	COG2217	Heavy metal translocating P-type atpase
MZO50_06130	COG0339	signal peptide processing
MZO50_06150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MZO50_06155	COG0546	phosphoglycolate phosphatase activity
MZO50_06160	COG4206	TonB-dependent receptor
MZO50_06170	COG1956	GAF domain-containing protein
MZO50_06175	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MZO50_06185	COG0720	synthase
MZO50_06200	COG0625	glutathione transferase activity
MZO50_06230	COG0626	cystathionine gamma-synthase activity
MZO50_06245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MZO50_06250	COG0438	transferase activity, transferring glycosyl groups
MZO50_06250	COG1216	Glycosyl transferase, family 2
MZO50_06255	COG0438	transferase activity, transferring glycosyl groups
MZO50_06255	COG1216	Glycosyl transferase, family 2
MZO50_06300	COG0493	'glutamate synthase
MZO50_06315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MZO50_06320	COG0300	oxidoreductase activity
MZO50_06325	COG0277	FAD linked oxidase domain protein
MZO50_06330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
MZO50_06330	COG0546	phosphoglycolate phosphatase activity
MZO50_06345	COG2086	electron transfer activity
MZO50_06370	COG0662	Cupin 2, conserved barrel domain protein
MZO50_06370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
MZO50_06375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MZO50_06380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MZO50_06410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MZO50_06410	COG3218	ABC-type transport auxiliary lipoprotein component
MZO50_06415	COG1127	ABC transporter
MZO50_06420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MZO50_06435	COG0442	prolyl-tRNA aminoacylation
MZO50_06445	COG1183	phosphatidylcholine synthase activity
MZO50_06480	COG2927	DNA polymerase III (CHI subunit)
MZO50_06485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MZO50_06510	COG4974	Belongs to the 'phage' integrase family
MZO50_06515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MZO50_06520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MZO50_06520	COG0047	phosphoribosylformylglycinamidine synthase activity
MZO50_06525	COG0840	transmembrane signaling receptor activity
MZO50_06535	COG5295	Hep Hag repeat protein
MZO50_06540	COG1404	Belongs to the peptidase S8 family
MZO50_06545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MZO50_06550	COG1459	type II secretion system
MZO50_06555	COG2165	general secretion pathway protein
MZO50_06560	COG4970	Tfp pilus assembly protein FimT
MZO50_06565	COG2165	general secretion pathway protein
MZO50_06570	COG4795	General secretion pathway protein
MZO50_06575	COG3156	type II secretion system protein K
MZO50_06580	COG3166	PFAM Fimbrial assembly family protein
MZO50_06595	COG1450	Type ii and iii secretion system protein
MZO50_06605	COG2188	Transcriptional regulator
MZO50_06665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MZO50_06675	COG1215	transferase activity, transferring glycosyl groups
MZO50_06700	COG0242	peptide deformylase activity
MZO50_06705	COG0488	(ABC) transporter
MZO50_06710	COG0477	Major facilitator Superfamily
MZO50_06740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MZO50_06750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MZO50_06750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MZO50_06765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MZO50_06770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MZO50_06775	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MZO50_06800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
MZO50_06805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MZO50_06815	COG2205	protein histidine kinase activity
MZO50_06820	COG0745	RESPONSE REGULATOR receiver
MZO50_06825	COG0277	FAD linked oxidase domain protein
MZO50_06835	COG0792	nuclease activity
MZO50_06870	COG2001	Belongs to the MraZ family
MZO50_06875	COG0275	rRNA processing
MZO50_06880	COG3116	cell division
MZO50_06895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MZO50_06920	COG1181	Belongs to the D-alanine--D-alanine ligase family
MZO50_06925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MZO50_06935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MZO50_06940	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
MZO50_06950	COG0739	heme binding
MZO50_06965	COG0494	nUDIX hydrolase
MZO50_06975	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MZO50_07000	COG2226	methyltransferase
MZO50_07040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MZO50_07055	COG1090	epimerase
MZO50_07065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MZO50_07070	COG0673	inositol 2-dehydrogenase activity
MZO50_07075	COG2823	Periplasmic or secreted lipoprotein
MZO50_07085	COG2205	protein histidine kinase activity
MZO50_07085	COG2202	Pas domain
MZO50_07090	COG0784	Response regulator, receiver
MZO50_07095	COG4191	Histidine kinase
MZO50_07105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MZO50_07145	COG3250	beta-galactosidase activity
MZO50_07160	COG2188	Transcriptional regulator
MZO50_07165	COG0738	Major facilitator superfamily
MZO50_07170	COG1609	Transcriptional regulator
MZO50_07175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MZO50_07180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MZO50_07185	COG0617	tRNA 3'-terminal CCA addition
MZO50_07255	COG2205	protein histidine kinase activity
MZO50_07270	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MZO50_07275	COG3791	Glutathione-dependent formaldehyde-activating
MZO50_07285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MZO50_07315	COG0804	urea catabolic process
MZO50_07320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MZO50_07340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MZO50_07365	COG0436	Aminotransferase
MZO50_07370	COG1162	GTPase activity
MZO50_07395	COG2211	Major facilitator Superfamily
MZO50_07405	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_07410	COG2851	Citrate transporter
MZO50_07425	COG0642	Histidine kinase
MZO50_07445	COG4191	Histidine kinase
MZO50_07455	COG1301	dicarboxylic acid transport
MZO50_07460	COG0281	malic enzyme
MZO50_07460	COG0280	phosphate acetyltransferase
MZO50_07535	COG1560	Kdo2-lipid A biosynthetic process
MZO50_07540	COG1519	Transferase
MZO50_07545	COG1538	Outer membrane efflux protein
MZO50_07550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
MZO50_07560	COG3706	GGDEF domain
MZO50_07565	COG0473	3-isopropylmalate dehydrogenase activity
MZO50_07570	COG0066	3-isopropylmalate dehydratase activity
MZO50_07580	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MZO50_07590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MZO50_07610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MZO50_07615	COG0840	transmembrane signaling receptor activity
MZO50_07640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MZO50_07650	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MZO50_07675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MZO50_07685	COG0671	phosphoesterase, PA-phosphatase related
MZO50_07700	COG1940	carbohydrate kinase activity
MZO50_07710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MZO50_07745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MZO50_07760	COG1773	rubredoxin
MZO50_07775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MZO50_07785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MZO50_07810	COG3079	Belongs to the UPF0149 family
MZO50_07815	COG0006	proline dipeptidase activity
MZO50_07835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MZO50_07865	COG0714	Associated with various cellular activities
MZO50_07895	COG1301	dicarboxylic acid transport
MZO50_07900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MZO50_07925	COG0739	heme binding
MZO50_07930	COG1376	ErfK ybiS ycfS ynhG family protein
MZO50_07955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MZO50_07960	COG4149	molybdate abc transporter
MZO50_07965	COG0725	ABC transporter, periplasmic molybdate-binding protein
MZO50_07975	COG0640	Transcriptional regulator
MZO50_07995	COG3047	cAMP biosynthetic process
MZO50_08000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MZO50_08045	COG0469	pyruvate kinase activity
MZO50_08050	COG3588	fructose-bisphosphate aldolase
MZO50_08055	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MZO50_08095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MZO50_08110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MZO50_08110	COG1648	precorrin-2 dehydrogenase activity
MZO50_08125	COG0784	Response regulator, receiver
MZO50_08125	COG2198	Histidine kinase
MZO50_08125	COG2205	protein histidine kinase activity
MZO50_08130	COG1393	Belongs to the ArsC family
MZO50_08160	COG0175	sulfate reduction
MZO50_08165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MZO50_08170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MZO50_08180	COG2895	sulfate adenylyltransferase (ATP) activity
MZO50_08180	COG0529	Catalyzes the synthesis of activated sulfate
MZO50_08185	COG0840	transmembrane signaling receptor activity
MZO50_08220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MZO50_08240	COG1609	Transcriptional regulator
MZO50_08255	COG0179	Fumarylacetoacetate (FAA) hydrolase
MZO50_08270	COG3273	potassium ion transport
MZO50_08270	COG0471	metal ion transport
MZO50_08280	COG2022	thiamine diphosphate biosynthetic process
MZO50_08305	COG0174	glutamine synthetase
MZO50_08310	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MZO50_08320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MZO50_08335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MZO50_08360	COG3511	phospholipase C
MZO50_08370	COG0189	ligase activity
MZO50_08380	COG0745	RESPONSE REGULATOR receiver
MZO50_08395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MZO50_08450	COG4993	Dehydrogenase
MZO50_08465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MZO50_08465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MZO50_08475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MZO50_08490	COG1174	glycine betaine transport
MZO50_08495	COG1125	glycine betaine transport
MZO50_08505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MZO50_08510	COG0564	pseudouridine synthase activity
MZO50_08530	COG4993	Dehydrogenase
MZO50_08545	COG3387	PFAM Glycoside hydrolase 15-related
MZO50_08570	COG0454	-acetyltransferase
MZO50_08595	COG0542	response to heat
MZO50_08620	COG0019	diaminopimelate decarboxylase activity
MZO50_08625	COG4264	IucA IucC family
MZO50_08630	COG2814	Major facilitator Superfamily
MZO50_08635	COG4264	IucA IucC family
MZO50_08645	COG4772	TonB-dependent receptor
MZO50_08655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MZO50_08655	COG4651	solute:proton antiporter activity
MZO50_08710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MZO50_08710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MZO50_08730	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MZO50_08770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MZO50_08775	COG1404	Belongs to the peptidase S8 family
MZO50_08785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MZO50_08805	COG1295	ribonuclease BN
MZO50_08810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MZO50_08830	COG0521	Mo-molybdopterin cofactor biosynthetic process
MZO50_08925	COG3209	COG3209 Rhs family protein
MZO50_09010	COG4682	membrane
MZO50_09225	COG3537	Alpha-1,2-mannosidase
MZO50_09245	COG1472	Belongs to the glycosyl hydrolase 3 family
MZO50_09255	COG3525	Glycosyl hydrolase, family 20, catalytic domain
MZO50_09260	COG3858	chitin binding
MZO50_09260	COG1388	LysM domain
MZO50_09280	COG0837	glucose binding
MZO50_09290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MZO50_09300	COG0494	nUDIX hydrolase
MZO50_09305	COG1218	3'(2'),5'-bisphosphate nucleotidase
MZO50_09310	COG3956	TIGRFAM MazG family protein
MZO50_09315	COG1742	UPF0060 membrane protein
MZO50_09325	COG0330	HflC and HflK could
MZO50_09390	COG2124	cytochrome p450
MZO50_09395	COG2124	cytochrome p450
MZO50_09400	COG1141	Ferredoxin
MZO50_09405	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_09410	COG2124	cytochrome p450
MZO50_09415	COG0142	geranyltranstransferase activity
MZO50_09420	COG1657	PFAM Prenyltransferase squalene oxidase
MZO50_09430	COG1304	FMN binding
MZO50_09465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MZO50_09470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MZO50_09475	COG0463	Glycosyl transferase, family 2
MZO50_09480	COG0517	IMP dehydrogenase activity
MZO50_09485	COG2982	Protein involved in outer membrane biogenesis
MZO50_09490	COG1272	protein, Hemolysin III
MZO50_09495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MZO50_09505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MZO50_09510	COG0626	cystathionine gamma-synthase activity
MZO50_09515	COG0460	homoserine dehydrogenase
MZO50_09515	COG0527	aspartate kinase activity
MZO50_09530	COG1760	l-serine dehydratase
MZO50_09545	COG3038	cytochrome b561
MZO50_09565	COG2814	Major facilitator Superfamily
MZO50_09570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MZO50_09580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO50_09600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MZO50_09660	COG0519	Catalyzes the synthesis of GMP from XMP
MZO50_09675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MZO50_09695	COG0840	transmembrane signaling receptor activity
MZO50_09705	COG1113	amino acid transport
MZO50_09725	COG2239	Acts as a magnesium transporter
MZO50_09730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MZO50_09735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MZO50_09745	COG1660	Displays ATPase and GTPase activities
MZO50_09755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MZO50_09770	COG1137	ATPase activity
MZO50_09785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
MZO50_09830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MZO50_09855	COG0628	permease
MZO50_09865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MZO50_09870	COG3178	'Phosphotransferase
MZO50_09885	COG1555	photosystem II stabilization
MZO50_09905	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MZO50_09910	COG1477	protein flavinylation
MZO50_09935	COG4774	siderophore transport
MZO50_09940	COG2146	nitrite reductase [NAD(P)H] activity
MZO50_09950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MZO50_09955	COG0719	Fe-S assembly protein
MZO50_09960	COG0396	ATPase activity
MZO50_09965	COG0719	Fe-S assembly protein
MZO50_09980	COG0693	protein deglycase activity
MZO50_09995	COG0739	heme binding
MZO50_10010	COG1764	response to oxidative stress
MZO50_10020	COG0384	phenazine biosynthesis protein PhzF
MZO50_10025	COG0527	aspartate kinase activity
MZO50_10050	COG0142	geranyltranstransferase activity
MZO50_10055	COG0629	single-stranded DNA binding
MZO50_10085	COG3104	oligopeptide transport
MZO50_10090	COG1297	OPT oligopeptide transporter protein
MZO50_10095	COG0823	Involved in the tonB-independent uptake of proteins
MZO50_10095	COG1506	peptidase
MZO50_10115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MZO50_10120	COG2879	small protein
MZO50_10125	COG1966	Carbon starvation protein
MZO50_10160	COG2211	Major facilitator Superfamily
MZO50_10190	COG0835	chemotaxis
MZO50_10195	COG0840	transmembrane signaling receptor activity
MZO50_10200	COG0840	transmembrane signaling receptor activity
MZO50_10210	COG0643	Histidine kinase
MZO50_10210	COG2198	Histidine kinase
MZO50_10240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MZO50_10250	COG2205	protein histidine kinase activity
MZO50_10285	COG0735	belongs to the Fur family
MZO50_10325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MZO50_10330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MZO50_10335	COG2080	2 iron, 2 sulfur cluster binding
MZO50_10445	COG1187	pseudouridine synthase activity
MZO50_10470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MZO50_10490	COG1132	(ABC) transporter
MZO50_10540	COG1061	Type III restriction enzyme res subunit
MZO50_10610	COG1981	membrane
MZO50_10635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO50_10640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO50_10650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO50_10660	COG0750	zinc metalloprotease
MZO50_10665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MZO50_10670	COG0575	Belongs to the CDS family
MZO50_10675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MZO50_10685	COG0528	UMP kinase activity
MZO50_10695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MZO50_10735	COG0024	Methionine aminopeptidase
MZO50_10750	COG1393	Belongs to the ArsC family
MZO50_10755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MZO50_10765	COG0367	asparagine synthase
MZO50_10805	COG1566	PFAM secretion protein HlyD family protein
MZO50_10810	COG2814	Major facilitator Superfamily
MZO50_10845	COG0557	exoribonuclease II activity
MZO50_10855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MZO50_10875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MZO50_10895	COG0704	Plays a role in the regulation of phosphate uptake
MZO50_10905	COG0581	inorganic phosphate transmembrane transporter activity
MZO50_10915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MZO50_10920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MZO50_10940	COG0659	secondary active sulfate transmembrane transporter activity
MZO50_10945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MZO50_10955	COG1024	Enoyl-CoA hydratase
MZO50_11015	COG5002	protein histidine kinase activity
MZO50_11015	COG0784	Response regulator, receiver
MZO50_11015	COG2205	protein histidine kinase activity
MZO50_11020	COG2733	membrane
MZO50_11040	COG0686	Belongs to the AlaDH PNT family
MZO50_11045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MZO50_11050	COG1396	sequence-specific DNA binding
MZO50_11050	COG1917	Cupin 2, conserved barrel domain protein
MZO50_11055	COG1012	belongs to the aldehyde dehydrogenase family
MZO50_11080	COG2223	nitrite transmembrane transporter activity
MZO50_11090	COG0243	molybdopterin cofactor binding
MZO50_11110	COG0477	Major facilitator Superfamily
MZO50_11120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MZO50_11125	COG0174	glutamine synthetase
MZO50_11130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MZO50_11135	COG0174	glutamine synthetase
MZO50_11150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MZO50_11170	COG3842	ATPase activity
MZO50_11175	COG1176	ABC-type spermidine putrescine transport system, permease component I
MZO50_11180	COG1177	transmembrane transport
MZO50_11190	COG1012	belongs to the aldehyde dehydrogenase family
MZO50_11205	COG4535	Mg2 and Co2 transporter CorC
MZO50_11220	COG1702	phosphate starvation-inducible protein PhoH
MZO50_11235	COG0741	lytic transglycosylase activity
MZO50_11240	COG0723	plastoquinol--plastocyanin reductase activity
MZO50_11245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MZO50_11255	COG2857	Cytochrome c1
MZO50_11260	COG0625	glutathione transferase activity
MZO50_11265	COG2969	positive regulation of protein catabolic process
MZO50_11305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MZO50_11310	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_11315	COG2095	MarC family integral membrane protein
MZO50_11325	COG1611	Belongs to the LOG family
MZO50_11330	COG3275	phosphorelay sensor kinase activity
MZO50_11440	COG2925	Exonuclease
MZO50_11450	COG3844	kynureninase activity
MZO50_11465	COG0288	reversible hydration of carbon dioxide
MZO50_11510	COG2197	response regulator
MZO50_11535	COG0316	Belongs to the HesB IscA family
MZO50_11570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MZO50_11575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MZO50_11580	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
MZO50_11590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MZO50_11610	COG1309	transcriptional regulator
MZO50_11625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MZO50_11640	COG1228	amidohydrolase
MZO50_11655	COG4221	oxidoreductase activity
MZO50_11695	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MZO50_11700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MZO50_11705	COG1605	Chorismate mutase
MZO50_11705	COG0077	Prephenate dehydratase
MZO50_11730	COG0583	DNA-binding transcription factor activity
MZO50_11805	COG1136	(ABC) transporter
MZO50_11805	COG0577	efflux transmembrane transporter activity
MZO50_11840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MZO50_11840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MZO50_11845	COG1105	Belongs to the carbohydrate kinase PfkB family
MZO50_11850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MZO50_11850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MZO50_11855	COG1609	Transcriptional regulator
MZO50_11865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
MZO50_11870	COG0069	glutamate synthase activity
MZO50_11905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MZO50_11920	COG1253	flavin adenine dinucleotide binding
MZO50_11930	COG0306	phosphate transporter
MZO50_11950	COG0504	CTP synthase activity
MZO50_11965	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MZO50_11970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MZO50_11975	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MZO50_11990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MZO50_12000	COG1238	metal cluster binding
MZO50_12015	COG1534	Rna-binding protein
MZO50_12020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
MZO50_12025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MZO50_12030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MZO50_12035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MZO50_12045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MZO50_12050	COG1546	Belongs to the CinA family
MZO50_12055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MZO50_12060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MZO50_12065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MZO50_12070	COG2137	regulation of response to DNA damage stimulus
MZO50_12080	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MZO50_12110	COG1741	Belongs to the pirin family
MZO50_12115	COG0583	DNA-binding transcription factor activity
MZO50_12135	COG0351	phosphomethylpyrimidine kinase
MZO50_12135	COG0352	thiamine-phosphate diphosphorylase activity
MZO50_12175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MZO50_12180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MZO50_12190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MZO50_12200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MZO50_12205	COG3734	2-keto-3-deoxy-galactonokinase
MZO50_12220	COG0800	Aldolase
MZO50_12255	COG0784	Response regulator, receiver
MZO50_12255	COG2198	Histidine kinase
MZO50_12255	COG2205	protein histidine kinase activity
MZO50_12260	COG1024	Enoyl-CoA hydratase
MZO50_12265	COG0318	PFAM AMP-dependent synthetase and ligase
MZO50_12345	COG0840	transmembrane signaling receptor activity
MZO50_12355	COG0835	chemotaxis
MZO50_12365	COG0840	transmembrane signaling receptor activity
MZO50_12375	COG0840	transmembrane signaling receptor activity
MZO50_12380	COG0840	transmembrane signaling receptor activity
MZO50_12385	COG0840	transmembrane signaling receptor activity
MZO50_12395	COG0840	transmembrane signaling receptor activity
MZO50_12405	COG0840	transmembrane signaling receptor activity
MZO50_12410	COG0840	transmembrane signaling receptor activity
MZO50_12420	COG0840	transmembrane signaling receptor activity
MZO50_12425	COG0840	transmembrane signaling receptor activity
MZO50_12440	COG0745	RESPONSE REGULATOR receiver
MZO50_12450	COG0835	chemotaxis
MZO50_12455	COG1192	Involved in chromosome partitioning
MZO50_12465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MZO50_12470	COG0643	Histidine kinase
MZO50_12470	COG0784	Response regulator, receiver
MZO50_12470	COG2198	Histidine kinase
MZO50_12475	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MZO50_12515	COG3706	GGDEF domain
MZO50_12525	COG1684	flagellar biosynthetic protein fliR
MZO50_12530	COG1987	bacterial-type flagellum assembly
MZO50_12540	COG3190	flagellar
MZO50_12590	COG1677	Flagellar hook-basal body complex protein FliE
MZO50_12625	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_12635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MZO50_12655	COG2201	protein-glutamate methylesterase activity
MZO50_12665	COG2197	response regulator
MZO50_12685	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MZO50_12690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MZO50_12700	COG1256	bacterial-type flagellum assembly
MZO50_12700	COG4786	Flagellar basal body rod
MZO50_12700	COG1256	bacterial-type flagellum assembly
MZO50_12700	COG4786	Flagellar basal body rod
MZO50_12715	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MZO50_12730	COG1749	Flagellar hook protein flgE
MZO50_12740	COG1558	bacterial-type flagellum-dependent cell motility
MZO50_12750	COG0835	chemotaxis
MZO50_12750	COG0784	Response regulator, receiver
MZO50_12810	COG2915	High frequency lysogenization protein hflD homolog
MZO50_12815	COG0482	sulfurtransferase activity
MZO50_12835	COG0542	response to heat
MZO50_12845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
MZO50_12855	COG0492	ferredoxin-NADP+ reductase activity
MZO50_12860	COG1674	ftsk spoiiie
MZO50_12880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MZO50_12885	COG0038	chloride channel
MZO50_12940	COG1595	DNA-templated transcription, initiation
MZO50_12960	COG3038	cytochrome b561
MZO50_12990	COG2244	polysaccharide biosynthetic process
MZO50_13010	COG4106	trans-aconitate 2-methyltransferase activity
MZO50_13030	COG0438	transferase activity, transferring glycosyl groups
MZO50_13035	COG0438	transferase activity, transferring glycosyl groups
MZO50_13050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MZO50_13055	COG2258	MOSC domain
MZO50_13065	COG0505	Belongs to the CarA family
MZO50_13075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MZO50_13080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MZO50_13115	COG1074	ATP-dependent DNA helicase activity
MZO50_13155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MZO50_13160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MZO50_13175	COG1024	Enoyl-CoA hydratase
MZO50_13185	COG1024	Enoyl-CoA hydratase
MZO50_13190	COG1024	Enoyl-CoA hydratase
MZO50_13240	COG0346	lactoylglutathione lyase activity
MZO50_13250	COG1304	FMN binding
MZO50_13255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MZO50_13260	COG1649	PFAM Uncharacterised BCR, COG1649
MZO50_13390	COG1196	nuclear chromosome segregation
MZO50_13470	COG3728	DNA packaging
MZO50_13470	COG5484	DNA packaging
MZO50_13545	COG0270	DNA (cytosine-5-)-methyltransferase activity
MZO50_13565	COG0305	Participates in initiation and elongation during chromosome replication
MZO50_13725	COG0784	Response regulator, receiver
MZO50_13725	COG2205	protein histidine kinase activity
MZO50_13730	COG2183	response to ionizing radiation
MZO50_13735	COG0784	Response regulator, receiver
MZO50_13735	COG4191	Histidine kinase
MZO50_13745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MZO50_13745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MZO50_13765	COG3243	poly(R)-hydroxyalkanoic acid synthase
MZO50_13775	COG1183	phosphatidylcholine synthase activity
MZO50_13780	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_13795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MZO50_13805	COG0668	transmembrane transport
MZO50_13810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MZO50_13825	COG1914	H( )-stimulated, divalent metal cation uptake system
MZO50_13835	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
MZO50_13840	COG1501	Belongs to the glycosyl hydrolase 31 family
MZO50_13845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MZO50_13845	COG0519	Catalyzes the synthesis of GMP from XMP
MZO50_13855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MZO50_13875	COG0475	glutathione-regulated potassium exporter activity
MZO50_13875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MZO50_13880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MZO50_13890	COG0746	molybdenum cofactor guanylyltransferase activity
MZO50_13900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MZO50_13910	COG1426	Protein conserved in bacteria
MZO50_13920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MZO50_13935	COG1024	Enoyl-CoA hydratase
MZO50_13935	COG1250	3-hydroxyacyl-CoA dehydrogenase
MZO50_13940	COG0183	Belongs to the thiolase family
MZO50_13945	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MZO50_13955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MZO50_13960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MZO50_13970	COG0776	regulation of translation
MZO50_13975	COG0539	negative regulation of cytoplasmic translation
MZO50_13980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MZO50_13985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MZO50_13995	COG2957	Belongs to the agmatine deiminase family
MZO50_14000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MZO50_14020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO50_14040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MZO50_14040	COG0316	Belongs to the HesB IscA family
MZO50_14055	COG0428	transporter
MZO50_14070	COG1530	ribonuclease E activity
MZO50_14100	COG1132	(ABC) transporter
MZO50_14140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MZO50_14150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MZO50_14155	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MZO50_14190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MZO50_14205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MZO50_14215	COG1663	tetraacyldisaccharide 4'-kinase activity
MZO50_14220	COG1132	(ABC) transporter
MZO50_14230	COG0811	peptide transport
MZO50_14250	COG4591	ABC-type transport system involved in lipoprotein release permease component
MZO50_14260	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MZO50_14265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MZO50_14275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MZO50_14280	COG2009	succinate dehydrogenase
MZO50_14300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MZO50_14315	COG0129	dihydroxy-acid dehydratase activity
MZO50_14330	COG0395	ABC-type sugar transport system, permease component
MZO50_14365	COG2350	Protein conserved in bacteria
MZO50_14370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MZO50_14375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MZO50_14380	COG1187	pseudouridine synthase activity
MZO50_14405	COG0436	Aminotransferase
MZO50_14410	COG4133	protoheme IX ABC transporter activity
MZO50_14455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MZO50_14460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MZO50_14465	COG4988	ABC transporter
MZO50_14475	COG1294	oxidase, subunit
MZO50_14500	COG2902	Dehydrogenase
MZO50_14510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO50_14515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MZO50_14535	COG0556	nucleotide-excision repair
MZO50_14635	COG1960	acyl-CoA dehydrogenase activity
MZO50_14640	COG2226	methyltransferase
MZO50_14645	COG1410	methionine synthase
MZO50_14645	COG0646	methionine synthase
MZO50_14650	COG1410	methionine synthase
MZO50_14650	COG0646	methionine synthase
MZO50_14670	COG2900	Belongs to the SlyX family
MZO50_14685	COG0386	Belongs to the glutathione peroxidase family
MZO50_14695	COG1725	Transcriptional regulator
MZO50_14700	COG1131	(ABC) transporter
MZO50_14745	COG2885	chlorophyll binding
MZO50_14750	COG2850	peptidyl-arginine hydroxylation
MZO50_14800	COG1132	(ABC) transporter
MZO50_14815	COG0287	Prephenate dehydrogenase
MZO50_14815	COG1605	Chorismate mutase
MZO50_14820	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MZO50_14825	COG0484	heat shock protein binding
MZO50_14830	COG0443	Heat shock 70 kDa protein
MZO50_14835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MZO50_14840	COG1420	regulation of RNA biosynthetic process
MZO50_14845	COG0497	DNA recombination
MZO50_14850	COG0735	belongs to the Fur family
MZO50_14855	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MZO50_14865	COG2867	negative regulation of translational initiation
MZO50_14870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MZO50_14875	COG1404	Belongs to the peptidase S8 family
MZO50_14915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MZO50_14930	COG0583	DNA-binding transcription factor activity
MZO50_14945	COG0415	Belongs to the DNA photolyase family
MZO50_14950	COG0305	Participates in initiation and elongation during chromosome replication
MZO50_14960	COG1960	acyl-CoA dehydrogenase activity
MZO50_14975	COG0084	hydrolase, TatD family'
MZO50_14980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MZO50_15030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MZO50_15070	COG1846	Transcriptional regulator
MZO50_15120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MZO50_15125	COG4290	ribonuclease
MZO50_15135	COG0488	(ABC) transporter
MZO50_15140	COG0513	Belongs to the DEAD box helicase family
MZO50_15165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MZO50_15170	COG0657	acetylesterase activity
MZO50_15175	COG0625	glutathione transferase activity
MZO50_15185	COG0564	pseudouridine synthase activity
MZO50_15190	COG4681	YaeQ
MZO50_15195	COG2081	HI0933 family
MZO50_15215	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_15235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MZO50_15240	COG0860	N-Acetylmuramoyl-L-alanine amidase
MZO50_15245	COG0802	atpase or kinase
MZO50_15250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MZO50_15250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MZO50_15255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MZO50_15300	COG1960	acyl-CoA dehydrogenase activity
MZO50_15310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MZO50_15335	COG0438	transferase activity, transferring glycosyl groups
MZO50_15345	COG0438	transferase activity, transferring glycosyl groups
MZO50_15350	COG0438	transferase activity, transferring glycosyl groups
MZO50_15400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MZO50_15405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MZO50_15415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MZO50_15445	COG1024	Enoyl-CoA hydratase
MZO50_15460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MZO50_15480	COG0277	FAD linked oxidase domain protein
MZO50_15485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MZO50_15500	COG0531	amino acid
MZO50_15505	COG0531	amino acid
MZO50_15510	COG0235	Class ii aldolase
MZO50_15515	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MZO50_15520	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
MZO50_15535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MZO50_15535	COG0140	phosphoribosyl-ATP diphosphatase activity
MZO50_15550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MZO50_15565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MZO50_15570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MZO50_15580	COG0124	histidyl-tRNA synthetase
MZO50_15585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MZO50_15595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MZO50_15605	COG2951	lytic endotransglycosylase activity
MZO50_15610	COG0083	homoserine kinase activity
MZO50_15615	COG0527	aspartate kinase activity
MZO50_15615	COG0460	homoserine dehydrogenase
MZO50_15630	COG1012	belongs to the aldehyde dehydrogenase family
MZO50_15645	COG0167	dihydroorotate dehydrogenase activity
MZO50_15650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MZO50_15675	COG0671	phosphoesterase, PA-phosphatase related
MZO50_15690	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
MZO50_15760	COG0166	Belongs to the GPI family
MZO50_15775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MZO50_15785	COG0617	tRNA 3'-terminal CCA addition
MZO50_15805	COG0860	N-Acetylmuramoyl-L-alanine amidase
MZO50_15810	COG0477	Major facilitator Superfamily
MZO50_15815	COG2115	Belongs to the xylose isomerase family
MZO50_15820	COG1070	Carbohydrate kinase
MZO50_15840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MZO50_15860	COG0165	Argininosuccinate lyase
MZO50_15865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MZO50_15875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MZO50_15880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MZO50_15885	COG0137	argininosuccinate synthase activity
MZO50_15890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MZO50_15905	COG2166	iron-sulfur cluster assembly
MZO50_15980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MZO50_15990	COG4677	pectinesterase activity
MZO50_15995	COG4677	pectinesterase activity
MZO50_16025	COG0402	S-adenosylhomocysteine deaminase activity
MZO50_16030	COG3548	integral membrane protein
MZO50_16040	COG1509	lysine 2,3-aminomutase activity
MZO50_16045	COG5001	Diguanylate cyclase
MZO50_16045	COG4251	negative regulation of phosphorylation
MZO50_16045	COG3706	GGDEF domain
MZO50_16045	COG2203	Gaf domain
MZO50_16070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MZO50_16075	COG1862	Preprotein translocase
MZO50_16085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MZO50_16095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MZO50_16110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MZO50_16115	COG3291	Pkd domain containing protein
MZO50_16120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MZO50_16125	COG0405	Gamma-glutamyltransferase
MZO50_16130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MZO50_16145	COG0742	ribosomal rna small subunit methyltransferase
MZO50_16170	COG4771	TonB-dependent receptor
MZO50_16180	COG3507	Belongs to the glycosyl hydrolase 43 family
MZO50_16220	COG0531	amino acid
MZO50_16235	COG0006	proline dipeptidase activity
MZO50_16245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MZO50_16260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MZO50_16265	COG3938	Belongs to the proline racemase family
MZO50_16275	COG0552	protein localization to endoplasmic reticulum
MZO50_16280	COG1194	a g-specific adenine glycosylase
MZO50_16330	COG0835	chemotaxis
MZO50_16345	COG0840	transmembrane signaling receptor activity
MZO50_16365	COG5001	Diguanylate cyclase
MZO50_16365	COG3300	MHYT domain
MZO50_16370	COG1185	polyribonucleotide nucleotidyltransferase activity
MZO50_16395	COG0195	Participates in both transcription termination and antitermination
MZO50_16410	COG1007	ATP synthesis coupled electron transport
MZO50_16425	COG0713	ATP synthesis coupled electron transport
MZO50_16445	COG1034	ATP synthesis coupled electron transport
MZO50_16450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MZO50_16455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MZO50_16460	COG0649	NAD binding
MZO50_16465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZO50_16475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MZO50_16495	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_16515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MZO50_16565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MZO50_16580	COG2890	protein-(glutamine-N5) methyltransferase activity
MZO50_16590	COG0688	phosphatidylethanolamine metabolic process
MZO50_16595	COG0741	lytic transglycosylase activity
MZO50_16600	COG0433	COG0433 Predicted ATPase
MZO50_16605	COG0494	nUDIX hydrolase
MZO50_16620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MZO50_16640	COG1714	RDD family
MZO50_16645	COG0717	Belongs to the dCTP deaminase family
MZO50_16650	COG0489	protein tyrosine kinase activity
MZO50_16660	COG4771	TonB-dependent receptor
MZO50_16665	COG4771	TonB-dependent receptor
MZO50_16670	COG0457	Tetratricopeptide repeat
MZO50_16685	COG3590	peptidase
MZO50_16715	COG0697	spore germination
MZO50_16735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MZO50_16740	COG2311	Membrane
MZO50_16745	COG1047	Peptidyl-prolyl cis-trans
MZO50_16750	COG0791	NLP P60 protein
MZO50_16755	COG0791	NLP P60 protein
MZO50_16770	COG1607	acyl-coa hydrolase
MZO50_16780	COG1301	dicarboxylic acid transport
MZO50_16785	COG1785	Belongs to the alkaline phosphatase family
MZO50_16795	COG0037	tRNA processing
MZO50_16800	COG1722	exodeoxyribonuclease VII activity
MZO50_16805	COG0142	geranyltranstransferase activity
MZO50_16815	COG1858	cytochrome C peroxidase
MZO50_16840	COG2815	serine threonine protein kinase
MZO50_16840	COG0515	serine threonine protein kinase
MZO50_16845	COG0631	protein serine/threonine phosphatase activity
MZO50_16945	COG0312	modulator of DNA gyrase
MZO50_16955	COG0312	modulator of DNA gyrase
MZO50_16975	COG2968	Membrane
MZO50_17000	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MZO50_17015	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MZO50_17030	COG0495	leucyl-tRNA aminoacylation
MZO50_17040	COG3118	belongs to the thioredoxin family
MZO50_17055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MZO50_17065	COG2040	homocysteine
MZO50_17070	COG0833	amino acid
MZO50_17080	COG0346	lactoylglutathione lyase activity
MZO50_17100	COG2878	Part of a membrane complex involved in electron transport
MZO50_17115	COG1595	DNA-templated transcription, initiation
MZO50_17140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MZO50_17160	COG0251	oxidation-reduction process
MZO50_17170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MZO50_17170	COG0392	lysyltransferase activity
MZO50_17200	COG2814	Major facilitator Superfamily
MZO50_17210	COG1902	pentaerythritol trinitrate reductase activity
MZO50_17215	COG2824	Alkylphosphonate utilization operon protein PhnA
MZO50_17220	COG1047	Peptidyl-prolyl cis-trans
MZO50_17225	COG1077	Cell shape determining protein MreB Mrl
MZO50_17260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MZO50_17270	COG1451	nucleotide metabolic process
MZO50_17295	COG0784	Response regulator, receiver
MZO50_17295	COG2198	Histidine kinase
MZO50_17295	COG2205	protein histidine kinase activity
MZO50_17305	COG2186	Transcriptional regulator
MZO50_17310	COG3250	beta-galactosidase activity
MZO50_17375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MZO50_17375	COG1703	isobutyryl-CoA mutase activity
MZO50_17375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MZO50_17405	COG0183	Belongs to the thiolase family
MZO50_17415	COG0443	Heat shock 70 kDa protein
MZO50_17450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MZO50_17450	COG1793	dna ligase
MZO50_17455	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MZO50_17455	COG1793	dna ligase
MZO50_17460	COG1201	RNA secondary structure unwinding
MZO50_17470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MZO50_17475	COG1278	Cold shock
MZO50_17480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MZO50_17485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MZO50_17490	COG1472	Belongs to the glycosyl hydrolase 3 family
MZO50_17500	COG2954	triphosphatase activity
MZO50_17510	COG0745	RESPONSE REGULATOR receiver
MZO50_17515	COG1381	Involved in DNA repair and RecF pathway recombination
MZO50_17520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MZO50_17535	COG0681	Belongs to the peptidase S26 family
MZO50_17540	COG0481	GTPase activity
MZO50_17545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MZO50_17575	COG2855	membrane
MZO50_17590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MZO50_17610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MZO50_17620	COG0534	Mate efflux family protein
MZO50_17625	COG0335	large ribosomal subunit rRNA binding
MZO50_17630	COG0336	Belongs to the RNA methyltransferase TrmD family
MZO50_17635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MZO50_17650	COG2070	2-Nitropropane dioxygenase
MZO50_17655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MZO50_17680	COG0475	glutathione-regulated potassium exporter activity
MZO50_17690	COG0625	glutathione transferase activity
MZO50_17695	COG1082	Xylose isomerase domain protein TIM barrel
MZO50_17705	COG1172	Belongs to the binding-protein-dependent transport system permease family
MZO50_17710	COG1172	Belongs to the binding-protein-dependent transport system permease family
MZO50_17715	COG1129	ABC transporter
MZO50_17720	COG1879	ABC-type sugar transport system periplasmic component
MZO50_17725	COG1012	belongs to the aldehyde dehydrogenase family
MZO50_17745	COG0129	dihydroxy-acid dehydratase activity
MZO50_17770	COG2207	Transcriptional regulator
MZO50_17790	COG1317	bacterial-type flagellum organization
MZO50_17815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MZO50_17840	COG4794	Type iii secretion
MZO50_17870	COG0745	RESPONSE REGULATOR receiver
MZO50_17900	COG3152	Membrane
MZO50_17910	COG0156	8-amino-7-oxononanoate synthase activity
MZO50_17920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MZO50_17925	COG1845	cytochrome c oxidase, subunit III
MZO50_17930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MZO50_17950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MZO50_17965	COG0196	riboflavin kinase activity
MZO50_17980	COG0728	peptidoglycan biosynthetic process
MZO50_17995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MZO50_18000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MZO50_18005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MZO50_18010	COG0824	Thioesterase
MZO50_18020	COG1024	Enoyl-CoA hydratase
MZO50_18025	COG1946	Acyl-CoA thioesterase
MZO50_18035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MZO50_18040	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
MZO50_18055	COG4638	Rieske (2fe-2S)
MZO50_18100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MZO50_18145	COG1643	Atp-dependent helicase
MZO50_18150	COG0783	Belongs to the Dps family
MZO50_18155	COG0514	ATP-dependent DNA helicase (RecQ)
MZO50_18175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MZO50_18180	COG0602	queuosine metabolic process
MZO50_18190	COG2885	chlorophyll binding
MZO50_18205	COG0848	biopolymer transport protein
MZO50_18215	COG0824	Thioesterase
MZO50_18220	COG2255	four-way junction helicase activity
MZO50_18225	COG3158	transport of potassium into the cell
MZO50_18230	COG0632	four-way junction helicase activity
MZO50_18240	COG0217	transcriptional regulatory protein
MZO50_18260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MZO50_18280	COG3142	Participates in the control of copper homeostasis
MZO50_18285	COG1446	asparaginase
MZO50_18290	COG3209	COG3209 Rhs family protein
MZO50_18300	COG2201	protein-glutamate methylesterase activity
MZO50_18310	COG0840	transmembrane signaling receptor activity
MZO50_18315	COG0835	chemotaxis
MZO50_18330	COG0189	ligase activity
MZO50_18350	COG1199	ATP-dependent helicase activity
MZO50_18360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MZO50_18365	COG1216	Glycosyl transferase, family 2
MZO50_18370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MZO50_18390	COG4585	Histidine kinase
MZO50_18400	COG0850	regulation of cytokinetic process
MZO50_18405	COG2894	cell division
MZO50_18410	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MZO50_18420	COG2205	protein histidine kinase activity
MZO50_18425	COG0745	RESPONSE REGULATOR receiver
MZO50_18435	COG2194	sulfuric ester hydrolase activity
MZO50_18455	COG2814	Major facilitator Superfamily
MZO50_18480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MZO50_18480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MZO50_18490	COG0753	catalase activity
MZO50_18500	COG4106	trans-aconitate 2-methyltransferase activity
MZO50_18515	COG1063	alcohol dehydrogenase
MZO50_18525	COG3459	Glycosyltransferase 36 associated
MZO50_18585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MZO50_18595	COG0330	HflC and HflK could
MZO50_18600	COG0330	HflC and HflK could
MZO50_18605	COG0604	alcohol dehydrogenase
MZO50_18625	COG0678	peroxiredoxin activity
MZO50_18635	COG4953	penicillin-binding protein 1C
MZO50_18655	COG2373	Large extracellular alpha-helical protein
MZO50_18680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MZO50_18695	COG0372	Belongs to the citrate synthase family
MZO50_18700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MZO50_18715	COG0587	DNA-directed DNA polymerase activity
MZO50_18750	COG2161	toxin-antitoxin pair type II binding
MZO50_18755	COG4115	mRNA cleavage
MZO50_18785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MZO50_18790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MZO50_18795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MZO50_18805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MZO50_18810	COG1028	Short-chain dehydrogenase reductase Sdr
MZO50_18815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MZO50_18820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MZO50_18830	COG1399	metal-binding, possibly nucleic acid-binding protein
MZO50_18855	COG0714	Associated with various cellular activities
MZO50_18875	COG0537	adenosine 5'-monophosphoramidase activity
MZO50_18970	COG0314	molybdopterin synthase activity
MZO50_18975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MZO50_18980	COG0315	cyclic pyranopterin monophosphate synthase activity
MZO50_18990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MZO50_18995	COG1234	tRNA 3'-trailer cleavage
MZO50_19005	COG0859	PFAM glycosyl transferase family 9
MZO50_19030	COG0631	protein serine/threonine phosphatase activity
MZO50_19035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MZO50_19040	COG0328	RNA-DNA hybrid ribonuclease activity
MZO50_19050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MZO50_19055	COG1388	LysM domain
MZO50_19055	COG3942	CHAP domain
MZO50_19090	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MZO50_19100	COG0544	peptidyl-prolyl cis-trans isomerase activity
MZO50_19140	COG0473	3-isopropylmalate dehydrogenase activity
MZO50_19155	COG4783	chaperone-mediated protein folding
MZO50_19170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MZO50_19175	COG0248	Ppx GppA phosphatase
MZO50_19180	COG0438	transferase activity, transferring glycosyl groups
MZO50_19190	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MZO50_19205	COG2833	Protein of unknown function (DUF455)
MZO50_19225	COG0285	dihydrofolate synthase activity
MZO50_19230	COG0588	phosphoglycerate mutase activity
MZO50_19250	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
MZO50_19255	COG4208	sulfate ABC transporter
MZO50_19260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
MZO50_19265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MZO50_19270	COG0156	8-amino-7-oxononanoate synthase activity
MZO50_19290	COG2885	chlorophyll binding
MZO50_19310	COG0667	Aldo Keto reductase
MZO50_19320	COG0446	pyridine nucleotide-disulphide oxidoreductase
MZO50_19320	COG1902	pentaerythritol trinitrate reductase activity
MZO50_19365	COG0625	glutathione transferase activity
MZO50_19390	COG0039	L-malate dehydrogenase activity
MZO50_19400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MZO50_19405	COG1217	gtp-binding protein TYPA
MZO50_19420	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MZO50_19430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MZO50_19435	COG0203	ribosomal protein L17
MZO50_19460	COG0201	protein transport
MZO50_19470	COG1841	ribosomal large subunit assembly
MZO50_19500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MZO50_19505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MZO50_19515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MZO50_19520	COG0255	Belongs to the universal ribosomal protein uL29 family
MZO50_19545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MZO50_19550	COG0089	rRNA binding
MZO50_19555	COG0088	Forms part of the polypeptide exit tunnel
MZO50_19565	COG0051	transcription antitermination factor activity, RNA binding
MZO50_19570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MZO50_19575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MZO50_19590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MZO50_19600	COG0222	ribosome binding
MZO50_19615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MZO50_19620	COG0250	Participates in transcription elongation, termination and antitermination
MZO50_19625	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MZO50_19635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MZO50_19655	COG0012	GTP binding
MZO50_19660	COG0193	aminoacyl-tRNA hydrolase activity
MZO50_19670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MZO50_19680	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MZO50_19695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MZO50_19700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MZO50_19745	COG0488	(ABC) transporter
MZO50_19785	COG3634	alkyl hydroperoxide reductase activity
MZO50_19790	COG0583	DNA-binding transcription factor activity
MZO50_19805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MZO50_19835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MZO50_19840	COG0697	spore germination
MZO50_19880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MZO50_19885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MZO50_19895	COG2096	Adenosyltransferase
MZO50_19905	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MZO50_19910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MZO50_19915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MZO50_19925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MZO50_19930	COG2967	ApaG domain
MZO50_19935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MZO50_19965	COG1704	LemA family
MZO50_19970	COG0861	Integral membrane protein TerC family
MZO50_19975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MZO50_19985	COG0642	Histidine kinase
MZO50_20000	COG4181	ATPase activity
MZO50_20005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MZO50_20025	COG4771	TonB-dependent receptor
MZO50_20035	COG0667	Aldo Keto reductase
MZO50_20040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MZO50_20060	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MZO50_20075	COG0372	Belongs to the citrate synthase family
MZO50_20080	COG0254	rRNA binding
MZO50_20090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MZO50_20115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MZO50_20120	COG1758	RNA polymerase activity
MZO50_20125	COG0194	GDP metabolic process
MZO50_20130	COG1561	YicC-like family, N-terminal region
MZO50_20135	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MZO50_20140	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MZO50_20145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MZO50_20185	COG1051	belongs to the nudix hydrolase family
MZO50_20185	COG1056	cytidyltransferase-related domain
MZO50_20210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MZO50_20215	COG0321	lipoyl(octanoyl) transferase activity
MZO50_20250	COG1686	Belongs to the peptidase S11 family
MZO50_20260	COG2951	lytic endotransglycosylase activity
MZO50_20275	COG0772	Belongs to the SEDS family
MZO50_20280	COG0768	penicillin binding
MZO50_20295	COG1077	Cell shape determining protein MreB Mrl
MZO50_20300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MZO50_20320	COG0508	dehydrogenase complex catalyzes the overall conversion of
MZO50_20320	COG0596	Alpha beta hydrolase
MZO50_20325	COG0308	aminopeptidase N
MZO50_20330	COG2226	methyltransferase
MZO50_20355	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MZO50_20375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MZO50_20385	COG2832	Protein of unknown function (DUF454)
MZO50_20395	COG0436	Aminotransferase
MZO50_20400	COG1505	serine-type exopeptidase activity
MZO50_20415	COG1733	regulation of RNA biosynthetic process
MZO50_20430	COG0181	hydroxymethylbilane synthase activity
MZO50_20455	COG0745	RESPONSE REGULATOR receiver
MZO50_20475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MZO50_20480	COG1640	4-alpha-glucanotransferase
MZO50_20505	COG0243	molybdopterin cofactor binding
MZO50_20510	COG2146	nitrite reductase [NAD(P)H] activity
MZO50_20515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MZO50_20520	COG2223	nitrite transmembrane transporter activity
MZO50_20525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MZO50_20525	COG1116	anion transmembrane transporter activity
MZO50_20535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MZO50_20535	COG1648	precorrin-2 dehydrogenase activity
MZO50_20555	COG3645	SOS response
MZO50_20570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification