locus-tag	class	description
CXP37_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXP37_00020	COG0187	DNA topoisomerase II activity
CXP37_00030	COG0501	Belongs to the peptidase M48B family
CXP37_00060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CXP37_00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXP37_00100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXP37_00105	COG0793	Belongs to the peptidase S41A family
CXP37_00110	COG4942	peptidase
CXP37_00120	COG2234	aminopeptidase activity
CXP37_00130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXP37_00140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXP37_00145	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXP37_00155	COG1064	alcohol dehydrogenase
CXP37_00170	COG0493	'glutamate synthase
CXP37_00175	COG0067	glutamate synthase
CXP37_00175	COG0069	glutamate synthase activity
CXP37_00175	COG0070	glutamate synthase
CXP37_00255	COG1205	dead DEAH box helicase
CXP37_00255	COG1111	helicase
CXP37_00260	COG1272	protein, Hemolysin III
CXP37_00300	COG2249	NAD(P)H dehydrogenase (quinone) activity
CXP37_00330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXP37_00335	COG0477	Major facilitator Superfamily
CXP37_00370	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CXP37_00390	COG3039	Transposase
CXP37_00400	COG4772	TonB-dependent receptor
CXP37_00425	COG1304	FMN binding
CXP37_00455	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CXP37_00485	COG2831	hemolysin activation secretion protein
CXP37_00490	COG3210	domain, Protein
CXP37_00520	COG3210	domain, Protein
CXP37_00550	COG3210	domain, Protein
CXP37_00565	COG0366	Alpha amylase catalytic
CXP37_00570	COG0366	Alpha amylase catalytic
CXP37_00595	COG0657	acetylesterase activity
CXP37_00595	COG2755	lipolytic protein G-D-S-L family
CXP37_00605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXP37_00620	COG3507	Belongs to the glycosyl hydrolase 43 family
CXP37_00625	COG1609	Transcriptional regulator
CXP37_00630	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CXP37_00635	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_00645	COG2755	lipolytic protein G-D-S-L family
CXP37_00655	COG3186	Phenylalanine-4-hydroxylase
CXP37_00660	COG1522	sequence-specific DNA binding
CXP37_00675	COG2951	lytic endotransglycosylase activity
CXP37_00680	COG1752	Esterase of the alpha-beta hydrolase superfamily
CXP37_00685	COG1473	amidohydrolase
CXP37_00695	COG1119	ATPase activity
CXP37_00710	COG1125	glycine betaine transport
CXP37_00710	COG0517	IMP dehydrogenase activity
CXP37_00725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXP37_00730	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CXP37_00740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXP37_00745	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CXP37_00775	COG0489	protein tyrosine kinase activity
CXP37_00780	COG2062	phosphohistidine phosphatase, SixA
CXP37_00790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXP37_00845	COG0174	glutamine synthetase
CXP37_00850	COG0347	Belongs to the P(II) protein family
CXP37_00855	COG0004	ammonium transporteR
CXP37_00860	COG3852	Histidine kinase
CXP37_00865	COG2204	response regulator
CXP37_00870	COG2032	superoxide dismutase activity
CXP37_00875	COG2032	superoxide dismutase activity
CXP37_00885	COG0346	lactoylglutathione lyase activity
CXP37_00895	COG0183	Belongs to the thiolase family
CXP37_00935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXP37_00940	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CXP37_00945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXP37_00955	COG0028	Belongs to the TPP enzyme family
CXP37_00960	COG2205	protein histidine kinase activity
CXP37_00985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CXP37_01000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXP37_01005	COG3177	Filamentation induced by cAMP protein fic
CXP37_01020	COG0596	Alpha beta hydrolase
CXP37_01030	COG0318	PFAM AMP-dependent synthetase and ligase
CXP37_01035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXP37_01055	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXP37_01075	COG0564	pseudouridine synthase activity
CXP37_01095	COG1446	asparaginase
CXP37_01100	COG0339	signal peptide processing
CXP37_01130	COG0475	glutathione-regulated potassium exporter activity
CXP37_01135	COG0583	DNA-binding transcription factor activity
CXP37_01140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXP37_01145	COG2224	Isocitrate lyase
CXP37_01150	COG3706	GGDEF domain
CXP37_01180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXP37_01185	COG1960	acyl-CoA dehydrogenase activity
CXP37_01240	COG0523	cobalamin synthesis protein
CXP37_01250	COG0697	spore germination
CXP37_01260	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXP37_01275	COG1846	Transcriptional regulator
CXP37_01280	COG1764	response to oxidative stress
CXP37_01305	COG2130	NADP-dependent
CXP37_01320	COG1187	pseudouridine synthase activity
CXP37_01330	COG1643	Atp-dependent helicase
CXP37_01335	COG4807	Protein conserved in bacteria
CXP37_01340	COG2351	hydroxyisourate hydrolase activity
CXP37_01345	COG2072	flavoprotein involved in K transport
CXP37_01365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CXP37_01460	COG2252	PERMEase
CXP37_01480	COG0084	hydrolase, TatD family'
CXP37_01520	COG0583	DNA-binding transcription factor activity
CXP37_01530	COG4221	oxidoreductase activity
CXP37_01540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CXP37_01545	COG1902	pentaerythritol trinitrate reductase activity
CXP37_01570	COG0745	RESPONSE REGULATOR receiver
CXP37_01590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXP37_01595	COG0583	DNA-binding transcription factor activity
CXP37_01630	COG0702	epimerase
CXP37_01635	COG1733	regulation of RNA biosynthetic process
CXP37_01705	COG0129	dihydroxy-acid dehydratase activity
CXP37_01720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CXP37_01780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXP37_01785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CXP37_01810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CXP37_01815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXP37_01825	COG3485	protocatechuate 3,4-dioxygenase
CXP37_01830	COG3485	protocatechuate 3,4-dioxygenase
CXP37_01840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXP37_01845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXP37_01850	COG1414	Transcriptional regulator
CXP37_01865	COG0445	tRNA wobble uridine modification
CXP37_01880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXP37_01925	COG0156	8-amino-7-oxononanoate synthase activity
CXP37_01930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXP37_01935	COG1040	competence protein
CXP37_01970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CXP37_02060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CXP37_02130	COG3264	Mechanosensitive ion channel
CXP37_02130	COG1511	domain protein
CXP37_02135	COG1368	sulfuric ester hydrolase activity
CXP37_02145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXP37_02150	COG2354	Protein conserved in bacteria
CXP37_02160	COG3706	GGDEF domain
CXP37_02160	COG0745	RESPONSE REGULATOR receiver
CXP37_02165	COG0297	glycogen (starch) synthase activity
CXP37_02170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXP37_02175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXP37_02200	COG0702	epimerase
CXP37_02205	COG3039	Transposase
CXP37_02210	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_02235	COG0513	Belongs to the DEAD box helicase family
CXP37_02250	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXP37_02265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXP37_02285	COG3104	oligopeptide transport
CXP37_02305	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXP37_02380	COG1320	monovalent cation:proton antiporter activity
CXP37_02385	COG2212	antiporter activity
CXP37_02395	COG0651	ATP synthesis coupled electron transport
CXP37_02400	COG1006	Multisubunit Na H antiporter MnhC subunit
CXP37_02405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXP37_02405	COG2111	Na H antiporter
CXP37_02460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXP37_02465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXP37_02475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXP37_02480	COG0456	acetyltransferase
CXP37_02485	COG1597	lipid kinase activity
CXP37_02515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXP37_02520	COG0134	indole-3-glycerol-phosphate synthase activity
CXP37_02530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXP37_02550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXP37_02590	COG0745	RESPONSE REGULATOR receiver
CXP37_02610	COG0316	Belongs to the HesB IscA family
CXP37_02625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CXP37_02645	COG2814	Major facilitator Superfamily
CXP37_02655	COG2814	Major facilitator Superfamily
CXP37_02660	COG1289	transmembrane transporter activity
CXP37_02665	COG0151	Belongs to the GarS family
CXP37_02675	COG0419	ATPase involved in DNA repair
CXP37_02680	COG0138	bifunctional purine biosynthesis protein purh
CXP37_02685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CXP37_02705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CXP37_02755	COG0439	Biotin carboxylase
CXP37_02765	COG0511	ligase activity, forming carbon-carbon bonds
CXP37_02770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXP37_02780	COG1324	tolerance protein
CXP37_02790	COG2356	endonuclease I
CXP37_02800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXP37_02825	COG4771	TonB-dependent receptor
CXP37_02830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXP37_02845	COG3386	PFAM SMP-30 Gluconolaconase
CXP37_02855	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXP37_02895	COG0778	Nitroreductase
CXP37_02900	COG2353	YceI-like domain
CXP37_02940	COG3052	prosthetic group binding
CXP37_02975	COG1802	Transcriptional regulator
CXP37_03025	COG2176	DNA-directed DNA polymerase activity
CXP37_03125	COG4221	oxidoreductase activity
CXP37_03130	COG0435	Glutathione S-transferase
CXP37_03195	COG0697	spore germination
CXP37_03210	COG4305	rare lipoprotein A
CXP37_03220	COG1113	amino acid transport
CXP37_03230	COG0598	Magnesium transport protein CorA
CXP37_03285	COG0840	transmembrane signaling receptor activity
CXP37_03290	COG5297	Belongs to the glycosyl hydrolase family 6
CXP37_03290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXP37_03295	COG0659	secondary active sulfate transmembrane transporter activity
CXP37_03320	COG2943	transferase activity, transferring hexosyl groups
CXP37_03330	COG3275	phosphorelay sensor kinase activity
CXP37_03340	COG0181	hydroxymethylbilane synthase activity
CXP37_03370	COG1505	serine-type exopeptidase activity
CXP37_03395	COG2832	Protein of unknown function (DUF454)
CXP37_03405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXP37_03415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXP37_03425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CXP37_03430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CXP37_03455	COG2226	methyltransferase
CXP37_03465	COG5001	Diguanylate cyclase
CXP37_03465	COG3300	MHYT domain
CXP37_03470	COG0308	aminopeptidase N
CXP37_03505	COG0730	response to heat
CXP37_03510	COG1012	belongs to the aldehyde dehydrogenase family
CXP37_03515	COG0367	asparagine synthase
CXP37_03530	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CXP37_03530	COG0028	Belongs to the TPP enzyme family
CXP37_03555	COG1077	Cell shape determining protein MreB Mrl
CXP37_03560	COG1792	Involved in formation and maintenance of cell shape
CXP37_03575	COG0772	Belongs to the SEDS family
CXP37_03590	COG5297	Belongs to the glycosyl hydrolase family 6
CXP37_03635	COG2951	lytic endotransglycosylase activity
CXP37_03640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXP37_03645	COG1686	Belongs to the peptidase S11 family
CXP37_03660	COG0321	lipoyl(octanoyl) transferase activity
CXP37_03665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXP37_03680	COG1051	belongs to the nudix hydrolase family
CXP37_03680	COG1056	cytidyltransferase-related domain
CXP37_03715	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CXP37_03720	COG0673	inositol 2-dehydrogenase activity
CXP37_03725	COG2823	Periplasmic or secreted lipoprotein
CXP37_03730	COG4251	negative regulation of phosphorylation
CXP37_03735	COG0784	Response regulator, receiver
CXP37_03740	COG4191	Histidine kinase
CXP37_03745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CXP37_03750	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_03780	COG3250	beta-galactosidase activity
CXP37_03805	COG1609	Transcriptional regulator
CXP37_03810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXP37_03815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CXP37_03830	COG1215	transferase activity, transferring glycosyl groups
CXP37_03835	COG0726	polysaccharide deacetylase
CXP37_03835	COG1649	PFAM Uncharacterised BCR, COG1649
CXP37_03860	COG4206	TonB-dependent receptor
CXP37_03895	COG0525	valine-tRNA ligase activity
CXP37_03910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXP37_03920	COG0795	lipopolysaccharide-transporting ATPase activity
CXP37_03930	COG4974	Belongs to the 'phage' integrase family
CXP37_03935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXP37_03945	COG0047	phosphoribosylformylglycinamidine synthase activity
CXP37_03945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXP37_03955	COG5295	Hep Hag repeat protein
CXP37_03965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CXP37_03975	COG1459	type II secretion system
CXP37_03980	COG2165	general secretion pathway protein
CXP37_03985	COG4970	Tfp pilus assembly protein FimT
CXP37_03990	COG2165	general secretion pathway protein
CXP37_03995	COG4795	General secretion pathway protein
CXP37_04000	COG3156	type II secretion system protein K
CXP37_04005	COG3166	PFAM Fimbrial assembly family protein
CXP37_04020	COG1450	Type ii and iii secretion system protein
CXP37_04030	COG2188	Transcriptional regulator
CXP37_04080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXP37_04110	COG0242	peptide deformylase activity
CXP37_04115	COG0488	(ABC) transporter
CXP37_04140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXP37_04145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CXP37_04155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXP37_04155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXP37_04175	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXP37_04185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CXP37_04230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CXP37_04235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CXP37_04245	COG2205	protein histidine kinase activity
CXP37_04250	COG0745	RESPONSE REGULATOR receiver
CXP37_04255	COG0277	FAD linked oxidase domain protein
CXP37_04260	COG1988	membrane-bound metal-dependent
CXP37_04310	COG0275	rRNA processing
CXP37_04315	COG3116	cell division
CXP37_04330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CXP37_04335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXP37_04345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXP37_04350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXP37_04355	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXP37_04360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CXP37_04375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CXP37_04385	COG0739	heme binding
CXP37_04390	COG0653	protein targeting
CXP37_04395	COG0494	nUDIX hydrolase
CXP37_04410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CXP37_04420	COG3321	synthase
CXP37_04420	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_04420	COG0604	alcohol dehydrogenase
CXP37_04470	COG2226	methyltransferase
CXP37_04485	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXP37_04520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXP37_04535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXP37_04550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CXP37_04555	COG0667	Aldo Keto reductase
CXP37_04570	COG4771	TonB-dependent receptor
CXP37_04590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXP37_04595	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CXP37_04605	COG2175	clavaminate synthase activity
CXP37_04615	COG4181	ATPase activity
CXP37_04630	COG0642	Histidine kinase
CXP37_04645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CXP37_04665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXP37_04680	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXP37_04685	COG2967	ApaG domain
CXP37_04690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXP37_04700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXP37_04710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CXP37_04715	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXP37_04720	COG2096	Adenosyltransferase
CXP37_04735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXP37_04740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXP37_04765	COG3384	dioxygenase
CXP37_04770	COG0583	DNA-binding transcription factor activity
CXP37_04775	COG0318	PFAM AMP-dependent synthetase and ligase
CXP37_04785	COG1024	Enoyl-CoA hydratase
CXP37_04805	COG3386	PFAM SMP-30 Gluconolaconase
CXP37_04830	COG0697	spore germination
CXP37_04840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXP37_04855	COG0745	RESPONSE REGULATOR receiver
CXP37_04855	COG3706	GGDEF domain
CXP37_04865	COG3039	Transposase
CXP37_04875	COG2197	response regulator
CXP37_04885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXP37_04895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXP37_04900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXP37_04905	COG0583	DNA-binding transcription factor activity
CXP37_04910	COG3634	alkyl hydroperoxide reductase activity
CXP37_04920	COG2890	protein-(glutamine-N5) methyltransferase activity
CXP37_04965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXP37_04965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CXP37_04985	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CXP37_05010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CXP37_05030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXP37_05035	COG1404	Belongs to the peptidase S8 family
CXP37_05040	COG1404	Belongs to the peptidase S8 family
CXP37_05045	COG1404	Belongs to the peptidase S8 family
CXP37_05050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXP37_05075	COG1295	ribonuclease BN
CXP37_05080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXP37_05100	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXP37_05115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXP37_05125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CXP37_05130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXP37_05140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXP37_05145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXP37_05150	COG0193	aminoacyl-tRNA hydrolase activity
CXP37_05155	COG0012	GTP binding
CXP37_05175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXP37_05185	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXP37_05190	COG0250	Participates in transcription elongation, termination and antitermination
CXP37_05195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXP37_05200	COG0081	regulation of translation
CXP37_05205	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXP37_05215	COG0085	RNA polymerase activity
CXP37_05225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXP37_05230	COG0049	tRNA binding
CXP37_05235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXP37_05240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXP37_05260	COG0051	transcription antitermination factor activity, RNA binding
CXP37_05270	COG0088	Forms part of the polypeptide exit tunnel
CXP37_05280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXP37_05300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXP37_05305	COG0255	Belongs to the universal ribosomal protein uL29 family
CXP37_05310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXP37_05315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXP37_05320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXP37_05330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXP37_05350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXP37_05355	COG1841	ribosomal large subunit assembly
CXP37_05360	COG0200	Binds to the 23S rRNA
CXP37_05365	COG0201	protein transport
CXP37_05370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXP37_05375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXP37_05380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXP37_05385	COG0202	RNA polymerase activity
CXP37_05390	COG0203	ribosomal protein L17
CXP37_05395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXP37_05410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CXP37_05445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXP37_05455	COG0625	glutathione transferase activity
CXP37_05475	COG1902	pentaerythritol trinitrate reductase activity
CXP37_05475	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXP37_05480	COG0604	alcohol dehydrogenase
CXP37_05485	COG2885	chlorophyll binding
CXP37_05505	COG0156	8-amino-7-oxononanoate synthase activity
CXP37_05510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CXP37_05515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CXP37_05520	COG4208	sulfate ABC transporter
CXP37_05525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CXP37_05555	COG0406	alpha-ribazole phosphatase activity
CXP37_05565	COG0285	dihydrofolate synthase activity
CXP37_05585	COG2833	Protein of unknown function (DUF455)
CXP37_05590	COG3291	Pkd domain containing protein
CXP37_05600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXP37_05605	COG0671	phosphoesterase, PA-phosphatase related
CXP37_05610	COG0438	transferase activity, transferring glycosyl groups
CXP37_05625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CXP37_05640	COG4783	chaperone-mediated protein folding
CXP37_05660	COG0473	3-isopropylmalate dehydrogenase activity
CXP37_05700	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXP37_05705	COG0740	serine-type endopeptidase activity
CXP37_05710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXP37_05740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXP37_05750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXP37_05765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXP37_05775	COG0631	protein serine/threonine phosphatase activity
CXP37_05790	COG0859	PFAM glycosyl transferase family 9
CXP37_05795	COG3642	lipopolysaccharide core region biosynthetic process
CXP37_05800	COG1234	tRNA 3'-trailer cleavage
CXP37_05805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXP37_05820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CXP37_05825	COG0314	molybdopterin synthase activity
CXP37_05865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXP37_05875	COG0537	adenosine 5'-monophosphoramidase activity
CXP37_05895	COG0714	Associated with various cellular activities
CXP37_05915	COG1399	metal-binding, possibly nucleic acid-binding protein
CXP37_05925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXP37_05940	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_05955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CXP37_05960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXP37_05980	COG4115	mRNA cleavage
CXP37_05985	COG2161	toxin-antitoxin pair type II binding
CXP37_05995	COG3829	transcription factor binding
CXP37_06015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CXP37_06065	COG4953	penicillin-binding protein 1C
CXP37_06075	COG0678	peroxiredoxin activity
CXP37_06095	COG0330	HflC and HflK could
CXP37_06100	COG0330	HflC and HflK could
CXP37_06105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXP37_06110	COG0308	aminopeptidase N
CXP37_06150	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CXP37_06200	COG0406	alpha-ribazole phosphatase activity
CXP37_06200	COG0328	RNA-DNA hybrid ribonuclease activity
CXP37_06205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXP37_06215	COG3387	PFAM Glycoside hydrolase 15-related
CXP37_06220	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_06235	COG3039	Transposase
CXP37_06260	COG3293	Transposase
CXP37_06265	COG3537	Alpha-1,2-mannosidase
CXP37_06270	COG4221	oxidoreductase activity
CXP37_06280	COG0492	ferredoxin-NADP+ reductase activity
CXP37_06290	COG2200	EAL domain
CXP37_06290	COG2199	diguanylate cyclase activity
CXP37_06290	COG3287	FIST C domain
CXP37_06325	COG3039	Transposase
CXP37_06335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXP37_06340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CXP37_06345	COG2080	2 iron, 2 sulfur cluster binding
CXP37_06380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CXP37_06395	COG0587	DNA-directed DNA polymerase activity
CXP37_06430	COG1297	OPT oligopeptide transporter protein
CXP37_06450	COG1506	peptidase
CXP37_06450	COG0823	Involved in the tonB-independent uptake of proteins
CXP37_06480	COG2207	Transcriptional regulator
CXP37_06480	COG1917	Cupin 2, conserved barrel domain protein
CXP37_06545	COG0753	catalase activity
CXP37_06550	COG0656	L-ascorbic acid biosynthetic process
CXP37_06565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXP37_06565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXP37_06585	COG2814	Major facilitator Superfamily
CXP37_06600	COG2194	sulfuric ester hydrolase activity
CXP37_06615	COG0745	RESPONSE REGULATOR receiver
CXP37_06620	COG0642	Histidine kinase
CXP37_06630	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CXP37_06635	COG2894	cell division
CXP37_06640	COG0850	regulation of cytokinetic process
CXP37_06650	COG4585	Histidine kinase
CXP37_06655	COG2197	response regulator
CXP37_06670	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CXP37_06715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CXP37_06745	COG1946	Acyl-CoA thioesterase
CXP37_06760	COG0824	Thioesterase
CXP37_06765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CXP37_06770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXP37_06785	COG0268	Binds directly to 16S ribosomal RNA
CXP37_06790	COG0728	peptidoglycan biosynthetic process
CXP37_06795	COG0196	riboflavin kinase activity
CXP37_06800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXP37_06805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXP37_06810	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXP37_06825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXP37_06830	COG1845	cytochrome c oxidase, subunit III
CXP37_06835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CXP37_06850	COG3152	Membrane
CXP37_06865	COG2207	Transcriptional regulator
CXP37_06870	COG0326	Molecular chaperone. Has ATPase activity
CXP37_06880	COG1366	Belongs to the anti-sigma-factor antagonist family
CXP37_06885	COG1366	Belongs to the anti-sigma-factor antagonist family
CXP37_06890	COG2172	sigma factor antagonist activity
CXP37_06925	COG5507	3-demethylubiquinone-9 3-methyltransferase
CXP37_06930	COG2205	protein histidine kinase activity
CXP37_06940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CXP37_06945	COG3437	response regulator, receiver
CXP37_06945	COG4999	Histidine kinase
CXP37_06945	COG3850	Histidine kinase
CXP37_06945	COG2205	protein histidine kinase activity
CXP37_06950	COG0784	Response regulator, receiver
CXP37_06950	COG4191	Histidine kinase
CXP37_06970	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXP37_06975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXP37_06985	COG2070	2-Nitropropane dioxygenase
CXP37_06990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CXP37_06995	COG0228	four-way junction DNA binding
CXP37_07000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXP37_07005	COG0336	Belongs to the RNA methyltransferase TrmD family
CXP37_07015	COG0534	Mate efflux family protein
CXP37_07025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CXP37_07035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXP37_07045	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_07050	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_07055	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_07070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXP37_07085	COG3250	beta-galactosidase activity
CXP37_07095	COG3039	Transposase
CXP37_07120	COG1960	acyl-CoA dehydrogenase activity
CXP37_07125	COG1024	Enoyl-CoA hydratase
CXP37_07170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXP37_07190	COG0571	ribonuclease III activity
CXP37_07195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CXP37_07225	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CXP37_07230	COG3046	protein related to deoxyribodipyrimidine photolyase
CXP37_07235	COG1472	Belongs to the glycosyl hydrolase 3 family
CXP37_07245	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CXP37_07250	COG1278	Cold shock
CXP37_07255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXP37_07275	COG1793	dna ligase
CXP37_07285	COG1793	dna ligase
CXP37_07285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXP37_07320	COG0183	Belongs to the thiolase family
CXP37_07345	COG1451	nucleotide metabolic process
CXP37_07355	COG5487	UPF0391 membrane protein
CXP37_07365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXP37_07400	COG1047	Peptidyl-prolyl cis-trans
CXP37_07415	COG2824	Alkylphosphonate utilization operon protein PhnA
CXP37_07430	COG1902	pentaerythritol trinitrate reductase activity
CXP37_07435	COG2814	Major facilitator Superfamily
CXP37_07470	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CXP37_07470	COG0392	lysyltransferase activity
CXP37_07480	COG0251	oxidation-reduction process
CXP37_07485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXP37_07500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXP37_07525	COG1595	DNA-templated transcription, initiation
CXP37_07545	COG2878	Part of a membrane complex involved in electron transport
CXP37_07555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXP37_07555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXP37_07565	COG0346	lactoylglutathione lyase activity
CXP37_07570	COG0833	amino acid
CXP37_07575	COG2040	homocysteine
CXP37_07585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CXP37_07650	COG0825	malonyl-CoA metabolic process
CXP37_07665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXP37_07670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXP37_07675	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXP37_07680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXP37_07685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXP37_07700	COG0750	zinc metalloprotease
CXP37_07705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXP37_07725	COG0528	UMP kinase activity
CXP37_07730	COG3706	GGDEF domain
CXP37_07735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXP37_07775	COG0024	Methionine aminopeptidase
CXP37_07780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXP37_07795	COG1393	Belongs to the ArsC family
CXP37_07805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXP37_07810	COG0367	asparagine synthase
CXP37_07820	COG4774	siderophore transport
CXP37_07840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXP37_07870	COG1566	PFAM secretion protein HlyD family protein
CXP37_07875	COG2814	Major facilitator Superfamily
CXP37_07960	COG0339	signal peptide processing
CXP37_07970	COG0386	Belongs to the glutathione peroxidase family
CXP37_08030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXP37_08035	COG0084	hydrolase, TatD family'
CXP37_08050	COG1960	acyl-CoA dehydrogenase activity
CXP37_08070	COG0367	asparagine synthase
CXP37_08080	COG0305	Participates in initiation and elongation during chromosome replication
CXP37_08085	COG0415	Belongs to the DNA photolyase family
CXP37_08100	COG0583	DNA-binding transcription factor activity
CXP37_08135	COG3706	GGDEF domain
CXP37_08145	COG3706	GGDEF domain
CXP37_08185	COG0582	viral genome integration into host DNA
CXP37_08200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXP37_08210	COG2914	Belongs to the UPF0125 (RnfH) family
CXP37_08220	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXP37_08230	COG0497	DNA recombination
CXP37_08235	COG1420	regulation of RNA biosynthetic process
CXP37_08240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXP37_08245	COG0443	Heat shock 70 kDa protein
CXP37_08250	COG0484	heat shock protein binding
CXP37_08255	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CXP37_08285	COG0583	DNA-binding transcription factor activity
CXP37_08295	COG1132	(ABC) transporter
CXP37_08330	COG2850	peptidyl-arginine hydroxylation
CXP37_08360	COG1253	flavin adenine dinucleotide binding
CXP37_08390	COG1131	(ABC) transporter
CXP37_08395	COG1725	Transcriptional regulator
CXP37_08405	COG0386	Belongs to the glutathione peroxidase family
CXP37_08445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CXP37_08460	COG0646	methionine synthase
CXP37_08460	COG1410	methionine synthase
CXP37_08470	COG1960	acyl-CoA dehydrogenase activity
CXP37_08490	COG0557	exoribonuclease II activity
CXP37_08500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXP37_08505	COG3706	GGDEF domain
CXP37_08510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXP37_08520	COG0704	Plays a role in the regulation of phosphate uptake
CXP37_08525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXP37_08530	COG0581	inorganic phosphate transmembrane transporter activity
CXP37_08535	COG0573	inorganic phosphate transmembrane transporter activity
CXP37_08540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXP37_08570	COG0659	secondary active sulfate transmembrane transporter activity
CXP37_08575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXP37_08585	COG1024	Enoyl-CoA hydratase
CXP37_08595	COG0494	nUDIX hydrolase
CXP37_08640	COG0116	Belongs to the methyltransferase superfamily
CXP37_08640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CXP37_08645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXP37_08660	COG0667	Aldo Keto reductase
CXP37_08670	COG2925	Exonuclease
CXP37_08675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXP37_08680	COG3844	kynureninase activity
CXP37_08695	COG0288	reversible hydration of carbon dioxide
CXP37_08700	COG2808	Putative FMN-binding domain
CXP37_08720	COG0017	Asparaginyl-tRNA synthetase
CXP37_08725	COG0316	Belongs to the HesB IscA family
CXP37_08750	COG3115	cell septum assembly
CXP37_08760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXP37_08765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXP37_08770	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CXP37_08780	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CXP37_08815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CXP37_08825	COG2986	histidine ammonia-lyase
CXP37_08840	COG3039	Transposase
CXP37_08870	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CXP37_08875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CXP37_08880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXP37_08885	COG0077	Prephenate dehydratase
CXP37_08885	COG1605	Chorismate mutase
CXP37_08890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXP37_08905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXP37_08910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CXP37_08915	COG0583	DNA-binding transcription factor activity
CXP37_08960	COG0840	transmembrane signaling receptor activity
CXP37_08980	COG0784	Response regulator, receiver
CXP37_08980	COG5002	protein histidine kinase activity
CXP37_08980	COG2205	protein histidine kinase activity
CXP37_08985	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CXP37_08990	COG0784	Response regulator, receiver
CXP37_08990	COG4191	Histidine kinase
CXP37_09005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXP37_09015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CXP37_09025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CXP37_09095	COG2244	polysaccharide biosynthetic process
CXP37_09120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CXP37_09135	COG0438	transferase activity, transferring glycosyl groups
CXP37_09150	COG1136	(ABC) transporter
CXP37_09155	COG1132	(ABC) transporter
CXP37_09160	COG0477	Major facilitator Superfamily
CXP37_09170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXP37_09185	COG1253	flavin adenine dinucleotide binding
CXP37_09200	COG0306	phosphate transporter
CXP37_09205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CXP37_09215	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXP37_09220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CXP37_09225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXP37_09230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXP37_09235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXP37_09245	COG0776	regulation of translation
CXP37_09290	COG0438	transferase activity, transferring glycosyl groups
CXP37_09295	COG0438	transferase activity, transferring glycosyl groups
CXP37_09330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXP37_09335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXP37_09340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXP37_09360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXP37_09370	COG1960	acyl-CoA dehydrogenase activity
CXP37_09380	COG3040	lipid binding
CXP37_09405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXP37_09410	COG0784	Response regulator, receiver
CXP37_09410	COG4191	Histidine kinase
CXP37_09430	COG0552	protein localization to endoplasmic reticulum
CXP37_09440	COG3938	Belongs to the proline racemase family
CXP37_09445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXP37_09460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXP37_09470	COG0006	proline dipeptidase activity
CXP37_09485	COG0531	amino acid
CXP37_09585	COG0326	Molecular chaperone. Has ATPase activity
CXP37_09590	COG0742	ribosomal rna small subunit methyltransferase
CXP37_09595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXP37_09610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CXP37_09615	COG0405	Gamma-glutamyltransferase
CXP37_09630	COG3291	Pkd domain containing protein
CXP37_09635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXP37_09675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CXP37_09680	COG0343	queuine tRNA-ribosyltransferase activity
CXP37_09685	COG1862	Preprotein translocase
CXP37_09695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CXP37_09740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXP37_09740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXP37_09745	COG1105	Belongs to the carbohydrate kinase PfkB family
CXP37_09750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXP37_09750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXP37_09755	COG1609	Transcriptional regulator
CXP37_09790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXP37_09795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXP37_09805	COG2902	Dehydrogenase
CXP37_09810	COG0477	Major facilitator Superfamily
CXP37_09820	COG2205	protein histidine kinase activity
CXP37_09820	COG5002	protein histidine kinase activity
CXP37_09820	COG0784	Response regulator, receiver
CXP37_09825	COG2733	membrane
CXP37_09835	COG1121	(ABC) transporter
CXP37_09850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXP37_09855	COG0243	molybdopterin cofactor binding
CXP37_09870	COG0477	Major facilitator Superfamily
CXP37_09875	COG0745	RESPONSE REGULATOR receiver
CXP37_09875	COG3706	GGDEF domain
CXP37_09880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXP37_09885	COG0174	glutamine synthetase
CXP37_09890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXP37_09905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CXP37_09925	COG3842	ATPase activity
CXP37_09930	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXP37_09935	COG1177	transmembrane transport
CXP37_09940	COG1012	belongs to the aldehyde dehydrogenase family
CXP37_09955	COG4535	Mg2 and Co2 transporter CorC
CXP37_09980	COG1702	phosphate starvation-inducible protein PhoH
CXP37_10000	COG0741	lytic transglycosylase activity
CXP37_10005	COG0723	plastoquinol--plastocyanin reductase activity
CXP37_10010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXP37_10015	COG2857	Cytochrome c1
CXP37_10020	COG0625	glutathione transferase activity
CXP37_10025	COG2969	positive regulation of protein catabolic process
CXP37_10045	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CXP37_10050	COG1201	RNA secondary structure unwinding
CXP37_10055	COG2094	Belongs to the DNA glycosylase MPG family
CXP37_10060	COG0840	transmembrane signaling receptor activity
CXP37_10065	COG0835	chemotaxis
CXP37_10110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXP37_10125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CXP37_10130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CXP37_10130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXP37_10135	COG0802	atpase or kinase
CXP37_10140	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXP37_10145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CXP37_10170	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_10180	COG0501	Belongs to the peptidase M48B family
CXP37_10190	COG2081	HI0933 family
CXP37_10195	COG4681	YaeQ
CXP37_10210	COG0625	glutathione transferase activity
CXP37_10220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CXP37_10225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXP37_10230	COG0513	Belongs to the DEAD box helicase family
CXP37_10260	COG0483	inositol monophosphate 1-phosphatase activity
CXP37_10275	COG5001	Diguanylate cyclase
CXP37_10275	COG3300	MHYT domain
CXP37_10285	COG1509	lysine 2,3-aminomutase activity
CXP37_10290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXP37_10305	COG0402	S-adenosylhomocysteine deaminase activity
CXP37_10310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXP37_10345	COG4302	ethanolamine ammonia-lyase activity
CXP37_10360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CXP37_10370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXP37_10395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXP37_10400	COG0137	argininosuccinate synthase activity
CXP37_10410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXP37_10415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXP37_10425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXP37_10485	COG4988	ABC transporter
CXP37_10490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CXP37_10500	COG1278	Cold shock
CXP37_10505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXP37_10530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CXP37_10550	COG4133	protoheme IX ABC transporter activity
CXP37_10555	COG0436	Aminotransferase
CXP37_10580	COG1187	pseudouridine synthase activity
CXP37_10585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXP37_10590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CXP37_10595	COG2350	Protein conserved in bacteria
CXP37_10625	COG1175	transmembrane transport
CXP37_10630	COG0395	ABC-type sugar transport system, permease component
CXP37_10655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXP37_10665	COG2957	Belongs to the agmatine deiminase family
CXP37_10680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXP37_10685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXP37_10690	COG0539	negative regulation of cytoplasmic translation
CXP37_10705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CXP37_10720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CXP37_10735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXP37_10750	COG0582	viral genome integration into host DNA
CXP37_10790	COG5314	conjugation
CXP37_10835	COG4691	Plasmid stability protein
CXP37_10840	COG1487	ribonuclease activity
CXP37_10875	COG1196	nuclear chromosome segregation
CXP37_10895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXP37_10900	COG0583	DNA-binding transcription factor activity
CXP37_10905	COG0583	DNA-binding transcription factor activity
CXP37_10915	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_10925	COG0583	DNA-binding transcription factor activity
CXP37_10940	COG2197	response regulator
CXP37_10955	COG1335	isochorismatase
CXP37_10970	COG2814	Major facilitator Superfamily
CXP37_10985	COG1914	H( )-stimulated, divalent metal cation uptake system
CXP37_10990	COG1321	iron dependent repressor
CXP37_10995	COG0590	tRNA wobble adenosine to inosine editing
CXP37_11000	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXP37_11005	COG0668	transmembrane transport
CXP37_11015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CXP37_11030	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_11035	COG1183	phosphatidylcholine synthase activity
CXP37_11045	COG3243	poly(R)-hydroxyalkanoic acid synthase
CXP37_11060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXP37_11060	COG0723	plastoquinol--plastocyanin reductase activity
CXP37_11070	COG2183	response to ionizing radiation
CXP37_11080	COG2205	protein histidine kinase activity
CXP37_11080	COG0784	Response regulator, receiver
CXP37_11150	COG0800	Aldolase
CXP37_11155	COG0129	dihydroxy-acid dehydratase activity
CXP37_11160	COG0363	glucosamine-6-phosphate deaminase activity
CXP37_11165	COG0837	glucose binding
CXP37_11170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CXP37_11200	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CXP37_11215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXP37_11220	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CXP37_11230	COG4591	ABC-type transport system involved in lipoprotein release permease component
CXP37_11250	COG0811	peptide transport
CXP37_11260	COG1132	(ABC) transporter
CXP37_11265	COG1663	tetraacyldisaccharide 4'-kinase activity
CXP37_11270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CXP37_11275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXP37_11285	COG0322	excinuclease ABC activity
CXP37_11315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXP37_11345	COG1530	ribonuclease E activity
CXP37_11355	COG3064	Membrane
CXP37_11360	COG0428	transporter
CXP37_11375	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXP37_11525	COG1858	cytochrome C peroxidase
CXP37_11560	COG0631	protein serine/threonine phosphatase activity
CXP37_11595	COG3501	Rhs element vgr protein
CXP37_11660	COG2801	Transposase and inactivated derivatives
CXP37_11715	COG4566	intracellular signal transduction
CXP37_11725	COG5001	Diguanylate cyclase
CXP37_11735	COG3293	Transposase
CXP37_11745	COG3685	Protein conserved in bacteria
CXP37_11765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXP37_11765	COG1648	precorrin-2 dehydrogenase activity
CXP37_11775	COG0746	molybdenum cofactor guanylyltransferase activity
CXP37_11780	COG0303	'Molybdopterin
CXP37_11785	COG0708	Exodeoxyribonuclease III
CXP37_11825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXP37_11830	COG0303	'Molybdopterin
CXP37_11840	COG1160	GTP binding
CXP37_11845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXP37_11870	COG0105	UTP biosynthetic process
CXP37_11880	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXP37_11880	COG1024	Enoyl-CoA hydratase
CXP37_11885	COG0183	Belongs to the thiolase family
CXP37_11890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXP37_11895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXP37_11915	COG1674	ftsk spoiiie
CXP37_11920	COG0492	ferredoxin-NADP+ reductase activity
CXP37_11930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CXP37_11935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXP37_11940	COG0542	response to heat
CXP37_11945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXP37_11955	COG0482	sulfurtransferase activity
CXP37_11985	COG4585	Histidine kinase
CXP37_11995	COG5002	protein histidine kinase activity
CXP37_12020	COG0784	Response regulator, receiver
CXP37_12020	COG0835	chemotaxis
CXP37_12030	COG1558	bacterial-type flagellum-dependent cell motility
CXP37_12035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CXP37_12040	COG1749	Flagellar hook protein flgE
CXP37_12045	COG4787	bacterial-type flagellum-dependent cell motility
CXP37_12055	COG4786	Flagellar basal body rod
CXP37_12060	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CXP37_12065	COG1706	bacterial-type flagellum-dependent cell motility
CXP37_12085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CXP37_12090	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CXP37_12095	COG1516	flagellar protein fliS
CXP37_12120	COG2201	protein-glutamate methylesterase activity
CXP37_12125	COG2204	response regulator
CXP37_12140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CXP37_12145	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_12150	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_12180	COG1677	Flagellar hook-basal body complex protein FliE
CXP37_12230	COG3190	flagellar
CXP37_12240	COG1987	bacterial-type flagellum assembly
CXP37_12245	COG1684	flagellar biosynthetic protein fliR
CXP37_12250	COG5001	Diguanylate cyclase
CXP37_12250	COG3300	MHYT domain
CXP37_12255	COG5001	Diguanylate cyclase
CXP37_12255	COG3300	MHYT domain
CXP37_12285	COG0455	bacterial-type flagellum organization
CXP37_12305	COG0643	Histidine kinase
CXP37_12305	COG2198	Histidine kinase
CXP37_12400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CXP37_12405	COG1360	Flagellar Motor Protein
CXP37_12410	COG1192	Involved in chromosome partitioning
CXP37_12415	COG0835	chemotaxis
CXP37_12425	COG0745	RESPONSE REGULATOR receiver
CXP37_12435	COG0840	transmembrane signaling receptor activity
CXP37_12440	COG0840	transmembrane signaling receptor activity
CXP37_12455	COG0840	transmembrane signaling receptor activity
CXP37_12465	COG0840	transmembrane signaling receptor activity
CXP37_12470	COG0840	transmembrane signaling receptor activity
CXP37_12475	COG0840	transmembrane signaling receptor activity
CXP37_12480	COG0840	transmembrane signaling receptor activity
CXP37_12485	COG0840	transmembrane signaling receptor activity
CXP37_12490	COG0840	transmembrane signaling receptor activity
CXP37_12495	COG0840	transmembrane signaling receptor activity
CXP37_12500	COG0840	transmembrane signaling receptor activity
CXP37_12505	COG0840	transmembrane signaling receptor activity
CXP37_12515	COG0835	chemotaxis
CXP37_12525	COG0840	transmembrane signaling receptor activity
CXP37_12540	COG2201	protein-glutamate methylesterase activity
CXP37_12550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXP37_12580	COG0318	PFAM AMP-dependent synthetase and ligase
CXP37_12590	COG3039	Transposase
CXP37_12600	COG1024	Enoyl-CoA hydratase
CXP37_12610	COG0784	Response regulator, receiver
CXP37_12610	COG2205	protein histidine kinase activity
CXP37_12610	COG2198	Histidine kinase
CXP37_12620	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXP37_12630	COG3279	Response regulator of the LytR AlgR family
CXP37_12650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXP37_12660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXP37_12665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CXP37_12675	COG0505	Belongs to the CarA family
CXP37_12680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXP37_12685	COG2258	MOSC domain
CXP37_12690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXP37_12735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXP37_12755	COG0277	FAD linked oxidase domain protein
CXP37_12760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXP37_12770	COG0531	amino acid
CXP37_12775	COG0531	amino acid
CXP37_12780	COG0235	Class ii aldolase
CXP37_12810	COG0140	phosphoribosyl-ATP diphosphatase activity
CXP37_12810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXP37_12815	COG0107	imidazoleglycerol-phosphate synthase activity
CXP37_12820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXP37_12825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CXP37_12835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXP37_12840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CXP37_12845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXP37_12855	COG0124	histidyl-tRNA synthetase
CXP37_12860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXP37_12870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CXP37_12910	COG1012	belongs to the aldehyde dehydrogenase family
CXP37_12930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXP37_12935	COG0697	spore germination
CXP37_12945	COG1794	racemase activity, acting on amino acids and derivatives
CXP37_12960	COG0671	phosphoesterase, PA-phosphatase related
CXP37_12965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXP37_12975	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CXP37_12980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXP37_13005	COG1472	Belongs to the glycosyl hydrolase 3 family
CXP37_13030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXP37_13035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXP37_13040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXP37_13050	COG0617	tRNA 3'-terminal CCA addition
CXP37_13085	COG0477	Major facilitator Superfamily
CXP37_13095	COG1070	Carbohydrate kinase
CXP37_13105	COG1501	Belongs to the glycosyl hydrolase 31 family
CXP37_13165	COG0800	Aldolase
CXP37_13180	COG3734	2-keto-3-deoxy-galactonokinase
CXP37_13185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXP37_13195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXP37_13210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXP37_13215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXP37_13230	COG0351	phosphomethylpyrimidine kinase
CXP37_13230	COG0352	thiamine-phosphate diphosphorylase activity
CXP37_13255	COG0583	DNA-binding transcription factor activity
CXP37_13260	COG1741	Belongs to the pirin family
CXP37_13280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CXP37_13290	COG2137	regulation of response to DNA damage stimulus
CXP37_13310	COG1546	Belongs to the CinA family
CXP37_13315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXP37_13320	COG1923	regulation of RNA biosynthetic process
CXP37_13325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXP37_13330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CXP37_13335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXP37_13340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CXP37_13345	COG1534	Rna-binding protein
CXP37_13360	COG1238	metal cluster binding
CXP37_13365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXP37_13370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CXP37_13375	COG2840	Smr protein MutS2
CXP37_13400	COG0148	phosphopyruvate hydratase activity
CXP37_13420	COG0504	CTP synthase activity
CXP37_13500	COG3702	type iv secretory pathway
CXP37_13520	COG2948	multi-organism process
CXP37_13540	COG3505	Type IV secretory pathway VirD4
CXP37_13555	COG0556	nucleotide-excision repair
CXP37_13560	COG4969	Belongs to the N-Me-Phe pilin family
CXP37_13600	COG1611	Belongs to the LOG family
CXP37_13610	COG2095	MarC family integral membrane protein
CXP37_13620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXP37_13625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CXP37_13660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXP37_13670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXP37_13675	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXP37_13680	COG0195	Participates in both transcription termination and antitermination
CXP37_13685	COG0779	Required for maturation of 30S ribosomal subunits
CXP37_13695	COG1007	ATP synthesis coupled electron transport
CXP37_13710	COG0713	ATP synthesis coupled electron transport
CXP37_13720	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXP37_13725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CXP37_13730	COG1034	ATP synthesis coupled electron transport
CXP37_13735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CXP37_13740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CXP37_13750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXP37_13760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CXP37_13775	COG0149	triose-phosphate isomerase activity
CXP37_13780	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_13825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXP37_13850	COG0133	tryptophan synthase activity
CXP37_13860	COG0135	phosphoribosylanthranilate isomerase activity
CXP37_13865	COG0101	tRNA pseudouridine synthase activity
CXP37_13885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CXP37_13890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXP37_13900	COG2890	protein-(glutamine-N5) methyltransferase activity
CXP37_13910	COG0688	phosphatidylethanolamine metabolic process
CXP37_13915	COG0688	phosphatidylethanolamine metabolic process
CXP37_13925	COG0433	COG0433 Predicted ATPase
CXP37_13960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXP37_13970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXP37_14005	COG0717	Belongs to the dCTP deaminase family
CXP37_14015	COG0489	protein tyrosine kinase activity
CXP37_14035	COG3590	peptidase
CXP37_14040	COG3590	peptidase
CXP37_14060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXP37_14065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXP37_14070	COG2311	Membrane
CXP37_14075	COG1047	Peptidyl-prolyl cis-trans
CXP37_14080	COG0791	NLP P60 protein
CXP37_14085	COG0791	NLP P60 protein
CXP37_14100	COG1301	dicarboxylic acid transport
CXP37_14105	COG1785	Belongs to the alkaline phosphatase family
CXP37_14110	COG0037	tRNA processing
CXP37_14115	COG1722	exodeoxyribonuclease VII activity
CXP37_14120	COG0142	geranyltranstransferase activity
CXP37_14125	COG4104	PAAR repeat-containing protein
CXP37_14135	COG0312	modulator of DNA gyrase
CXP37_14145	COG0312	modulator of DNA gyrase
CXP37_14155	COG3164	Protein of unknown function
CXP37_14160	COG1530	ribonuclease E activity
CXP37_14170	COG2968	Membrane
CXP37_14185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CXP37_14205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXP37_14235	COG3118	belongs to the thioredoxin family
CXP37_14250	COG2155	Conserved Protein
CXP37_14310	COG1132	(ABC) transporter
CXP37_14335	COG1538	Outer membrane efflux protein
CXP37_14340	COG0745	RESPONSE REGULATOR receiver
CXP37_14345	COG5002	protein histidine kinase activity
CXP37_14345	COG5000	phosphorelay sensor kinase activity
CXP37_14350	COG0475	glutathione-regulated potassium exporter activity
CXP37_14355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXP37_14360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CXP37_14390	COG1187	pseudouridine synthase activity
CXP37_14395	COG5002	protein histidine kinase activity
CXP37_14395	COG5001	Diguanylate cyclase
CXP37_14510	COG0667	Aldo Keto reductase
CXP37_14515	COG2814	Major facilitator Superfamily
CXP37_14520	COG0583	DNA-binding transcription factor activity
CXP37_14535	COG2207	Transcriptional regulator
CXP37_14570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXP37_14595	COG1538	Outer membrane efflux protein
CXP37_14615	COG0735	belongs to the Fur family
CXP37_14620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXP37_14645	COG4452	Inner membrane protein CreD
CXP37_14660	COG2205	protein histidine kinase activity
CXP37_14675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CXP37_14685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXP37_14695	COG0643	Histidine kinase
CXP37_14695	COG2198	Histidine kinase
CXP37_14700	COG0840	transmembrane signaling receptor activity
CXP37_14705	COG0835	chemotaxis
CXP37_14715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CXP37_14725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXP37_14730	COG3590	peptidase
CXP37_14740	COG0588	phosphoglycerate mutase activity
CXP37_14745	COG1515	deoxyribonuclease V activity
CXP37_14750	COG1741	Belongs to the pirin family
CXP37_14770	COG1741	Belongs to the pirin family
CXP37_14775	COG1966	Carbon starvation protein
CXP37_14780	COG2879	small protein
CXP37_14810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CXP37_14815	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXP37_14825	COG2080	2 iron, 2 sulfur cluster binding
CXP37_14830	COG0604	alcohol dehydrogenase
CXP37_14830	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_14830	COG3321	synthase
CXP37_14835	COG4251	negative regulation of phosphorylation
CXP37_14835	COG2203	Gaf domain
CXP37_14835	COG3706	GGDEF domain
CXP37_14835	COG5001	Diguanylate cyclase
CXP37_14840	COG0629	single-stranded DNA binding
CXP37_14845	COG0142	geranyltranstransferase activity
CXP37_14870	COG0527	aspartate kinase activity
CXP37_14875	COG0384	phenazine biosynthesis protein PhzF
CXP37_14880	COG0384	phenazine biosynthesis protein PhzF
CXP37_14890	COG1764	response to oxidative stress
CXP37_14900	COG0540	Belongs to the ATCase OTCase family
CXP37_14905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CXP37_14910	COG1678	Uncharacterized ACR, COG1678
CXP37_14920	COG0519	Catalyzes the synthesis of GMP from XMP
CXP37_14945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CXP37_14960	COG4942	peptidase
CXP37_14980	COG0693	protein deglycase activity
CXP37_14990	COG1959	2 iron, 2 sulfur cluster binding
CXP37_14995	COG0719	Fe-S assembly protein
CXP37_15000	COG0396	ATPase activity
CXP37_15005	COG0719	Fe-S assembly protein
CXP37_15010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXP37_15030	COG4774	siderophore transport
CXP37_15035	COG3128	pkhd-type hydroxylase
CXP37_15060	COG1477	protein flavinylation
CXP37_15065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXP37_15075	COG1555	photosystem II stabilization
CXP37_15080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXP37_15090	COG3178	'Phosphotransferase
CXP37_15095	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXP37_15110	COG0628	permease
CXP37_15120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXP37_15130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXP37_15145	COG3039	Transposase
CXP37_15160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXP37_15165	COG0271	Belongs to the BolA IbaG family
CXP37_15175	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CXP37_15185	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CXP37_15190	COG1137	ATPase activity
CXP37_15205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXP37_15215	COG1660	Displays ATPase and GTPase activities
CXP37_15225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXP37_15230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXP37_15240	COG2239	Acts as a magnesium transporter
CXP37_15255	COG1294	oxidase, subunit
CXP37_15260	COG1271	oxidase subunit
CXP37_15270	COG1113	amino acid transport
CXP37_15275	COG3866	Pectate lyase
CXP37_15290	COG2197	response regulator
CXP37_15295	COG0531	amino acid
CXP37_15365	COG0789	Transcriptional regulator
CXP37_15370	COG2814	Major facilitator Superfamily
CXP37_15380	COG0754	glutathionylspermidine amidase activity
CXP37_15405	COG1842	Phage shock protein A
CXP37_15415	COG0259	pyridoxamine-phosphate oxidase activity
CXP37_15420	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXP37_15425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXP37_15440	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CXP37_15460	COG0784	Response regulator, receiver
CXP37_15460	COG5002	protein histidine kinase activity
CXP37_15465	COG0784	Response regulator, receiver
CXP37_15465	COG2198	Histidine kinase
CXP37_15465	COG2205	protein histidine kinase activity
CXP37_15470	COG2353	YceI-like domain
CXP37_15495	COG1760	l-serine dehydratase
CXP37_15505	COG0527	aspartate kinase activity
CXP37_15505	COG0460	homoserine dehydrogenase
CXP37_15510	COG0626	cystathionine gamma-synthase activity
CXP37_15515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXP37_15520	COG0739	heme binding
CXP37_15525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXP37_15530	COG1272	protein, Hemolysin III
CXP37_15535	COG2982	Protein involved in outer membrane biogenesis
CXP37_15545	COG0463	Glycosyl transferase, family 2
CXP37_15555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CXP37_15570	COG1309	transcriptional regulator
CXP37_15575	COG2267	carboxylic ester hydrolase activity
CXP37_15580	COG1960	acyl-CoA dehydrogenase activity
CXP37_15615	COG0509	glycine decarboxylation via glycine cleavage system
CXP37_15620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CXP37_15630	COG1742	UPF0060 membrane protein
CXP37_15635	COG3956	TIGRFAM MazG family protein
CXP37_15645	COG0494	nUDIX hydrolase
CXP37_15655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXP37_15660	COG0837	glucose binding
CXP37_15675	COG1388	LysM domain
CXP37_15675	COG3858	chitin binding
CXP37_15710	COG1472	Belongs to the glycosyl hydrolase 3 family
CXP37_15780	COG3537	Alpha-1,2-mannosidase
CXP37_15820	COG3142	Participates in the control of copper homeostasis
CXP37_15825	COG1446	asparaginase
CXP37_15855	COG2201	protein-glutamate methylesterase activity
CXP37_15865	COG0840	transmembrane signaling receptor activity
CXP37_15870	COG0835	chemotaxis
CXP37_15885	COG0189	ligase activity
CXP37_15895	COG1397	ADP-ribosylglycohydrolase
CXP37_15905	COG1199	ATP-dependent helicase activity
CXP37_15915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXP37_15925	COG1215	transferase activity, transferring glycosyl groups
CXP37_15940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXP37_15950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CXP37_15955	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CXP37_15985	COG0837	glucose binding
CXP37_16000	COG1643	Atp-dependent helicase
CXP37_16005	COG0783	Belongs to the Dps family
CXP37_16010	COG0514	ATP-dependent DNA helicase (RecQ)
CXP37_16045	COG1187	pseudouridine synthase activity
CXP37_16065	COG0840	transmembrane signaling receptor activity
CXP37_16095	COG0602	queuosine metabolic process
CXP37_16105	COG2885	chlorophyll binding
CXP37_16110	COG0823	Involved in the tonB-independent uptake of proteins
CXP37_16120	COG0848	biopolymer transport protein
CXP37_16130	COG0824	Thioesterase
CXP37_16140	COG3158	transport of potassium into the cell
CXP37_16150	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXP37_16170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXP37_16190	COG0477	Major facilitator Superfamily
CXP37_16220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXP37_16230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CXP37_16235	COG0174	glutamine synthetase
CXP37_16290	COG0488	(ABC) transporter
CXP37_16330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXP37_16330	COG4651	solute:proton antiporter activity
CXP37_16340	COG4772	TonB-dependent receptor
CXP37_16350	COG4264	IucA IucC family
CXP37_16355	COG2814	Major facilitator Superfamily
CXP37_16365	COG0019	diaminopimelate decarboxylase activity
CXP37_16420	COG0542	response to heat
CXP37_16425	COG1116	anion transmembrane transporter activity
CXP37_16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXP37_16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXP37_16440	COG0667	Aldo Keto reductase
CXP37_16450	COG4771	TonB-dependent receptor
CXP37_16455	COG2827	Endonuclease containing a URI domain
CXP37_16505	COG1877	trehalose-phosphatase activity
CXP37_16510	COG3387	PFAM Glycoside hydrolase 15-related
CXP37_16525	COG0840	transmembrane signaling receptor activity
CXP37_16530	COG3011	Protein conserved in bacteria
CXP37_16545	COG0564	pseudouridine synthase activity
CXP37_16550	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXP37_16555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CXP37_16555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXP37_16570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CXP37_16575	COG0045	succinate-CoA ligase (ADP-forming) activity
CXP37_16605	COG2194	sulfuric ester hydrolase activity
CXP37_16610	COG4969	Belongs to the N-Me-Phe pilin family
CXP37_16620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXP37_16635	COG0745	RESPONSE REGULATOR receiver
CXP37_16850	COG5001	Diguanylate cyclase
CXP37_16960	COG3077	Addiction module antitoxin, RelB DinJ family
CXP37_16990	COG0583	DNA-binding transcription factor activity
CXP37_16995	COG1396	sequence-specific DNA binding
CXP37_17015	COG0582	viral genome integration into host DNA
CXP37_17035	COG2022	thiamine diphosphate biosynthetic process
CXP37_17040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXP37_17045	COG3273	potassium ion transport
CXP37_17045	COG0471	metal ion transport
CXP37_17065	COG1970	mechanosensitive ion channel activity
CXP37_17075	COG1609	Transcriptional regulator
CXP37_17105	COG4948	Mandelate Racemase Muconate Lactonizing
CXP37_17120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXP37_17140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXP37_17150	COG2895	sulfate adenylyltransferase (ATP) activity
CXP37_17150	COG0529	Catalyzes the synthesis of activated sulfate
CXP37_17160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXP37_17165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXP37_17190	COG2205	protein histidine kinase activity
CXP37_17190	COG2198	Histidine kinase
CXP37_17190	COG0784	Response regulator, receiver
CXP37_17210	COG0583	DNA-binding transcription factor activity
CXP37_17235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CXP37_17240	COG3588	fructose-bisphosphate aldolase
CXP37_17245	COG0469	pyruvate kinase activity
CXP37_17280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXP37_17300	COG3047	cAMP biosynthetic process
CXP37_17310	COG3453	Protein conserved in bacteria
CXP37_17310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXP37_17315	COG0725	ABC transporter, periplasmic molybdate-binding protein
CXP37_17320	COG4149	molybdate abc transporter
CXP37_17360	COG1376	ErfK ybiS ycfS ynhG family protein
CXP37_17365	COG0739	heme binding
CXP37_17370	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_17375	COG0583	DNA-binding transcription factor activity
CXP37_17380	COG4773	Receptor
CXP37_17390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXP37_17395	COG1301	dicarboxylic acid transport
CXP37_17410	COG2304	oxidoreductase activity
CXP37_17430	COG0714	Associated with various cellular activities
CXP37_17460	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CXP37_17475	COG0254	rRNA binding
CXP37_17480	COG1957	nucleoside hydrolase
CXP37_17485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXP37_17495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXP37_17500	COG1758	RNA polymerase activity
CXP37_17510	COG1561	YicC-like family, N-terminal region
CXP37_17515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXP37_17530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXP37_17545	COG0006	proline dipeptidase activity
CXP37_17555	COG0006	proline dipeptidase activity
CXP37_17580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CXP37_17600	COG2912	Transglutaminase-like superfamily
CXP37_17605	COG1773	rubredoxin
CXP37_17610	COG0352	thiamine-phosphate diphosphorylase activity
CXP37_17635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXP37_17645	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CXP37_17650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXP37_17680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CXP37_17685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXP37_17695	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_17705	COG0671	phosphoesterase, PA-phosphatase related
CXP37_17710	COG3781	membrane
CXP37_17720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXP37_17740	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CXP37_17750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CXP37_17770	COG3710	Transcriptional regulator
CXP37_17790	COG0840	transmembrane signaling receptor activity
CXP37_17820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXP37_17825	COG0473	3-isopropylmalate dehydrogenase activity
CXP37_17830	COG2226	methyltransferase
CXP37_17835	COG0066	3-isopropylmalate dehydratase activity
CXP37_17840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXP37_17855	COG3706	GGDEF domain
CXP37_17870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXP37_17875	COG1538	Outer membrane efflux protein
CXP37_17880	COG1519	Transferase
CXP37_17885	COG1560	Kdo2-lipid A biosynthetic process
CXP37_17950	COG0280	phosphate acetyltransferase
CXP37_17950	COG0281	malic enzyme
CXP37_17955	COG1301	dicarboxylic acid transport
CXP37_17970	COG4191	Histidine kinase
CXP37_17985	COG0583	DNA-binding transcription factor activity
CXP37_17990	COG0667	Aldo Keto reductase
CXP37_18005	COG2197	response regulator
CXP37_18015	COG0642	Histidine kinase
CXP37_18040	COG2851	Citrate transporter
CXP37_18045	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_18050	COG1609	Transcriptional regulator
CXP37_18060	COG2211	Major facilitator Superfamily
CXP37_18085	COG1162	GTPase activity
CXP37_18090	COG0436	Aminotransferase
CXP37_18105	COG0726	polysaccharide deacetylase
CXP37_18110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXP37_18125	COG3964	amidohydrolase
CXP37_18130	COG0402	S-adenosylhomocysteine deaminase activity
CXP37_18190	COG3791	Glutathione-dependent formaldehyde-activating
CXP37_18210	COG0745	RESPONSE REGULATOR receiver
CXP37_18215	COG2205	protein histidine kinase activity
CXP37_18240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CXP37_18255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CXP37_18275	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CXP37_18280	COG0456	acetyltransferase
CXP37_18290	COG1183	phosphatidylcholine synthase activity
CXP37_18300	COG0442	prolyl-tRNA aminoacylation
CXP37_18315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXP37_18320	COG1127	ABC transporter
CXP37_18325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXP37_18325	COG3218	ABC-type transport auxiliary lipoprotein component
CXP37_18340	COG3293	Transposase
CXP37_18370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXP37_18375	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CXP37_18375	COG0662	Cupin 2, conserved barrel domain protein
CXP37_18400	COG2086	electron transfer activity
CXP37_18415	COG0546	phosphoglycolate phosphatase activity
CXP37_18415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CXP37_18420	COG0277	FAD linked oxidase domain protein
CXP37_18430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CXP37_18460	COG0438	transferase activity, transferring glycosyl groups
CXP37_18495	COG0626	cystathionine gamma-synthase activity
CXP37_18525	COG0625	glutathione transferase activity
CXP37_18540	COG0513	Belongs to the DEAD box helicase family
CXP37_18550	COG0720	synthase
CXP37_18560	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CXP37_18565	COG1956	GAF domain-containing protein
CXP37_18575	COG0546	phosphoglycolate phosphatase activity
CXP37_18580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXP37_18605	COG0339	signal peptide processing
CXP37_18655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXP37_18660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXP37_18665	COG1136	(ABC) transporter
CXP37_18670	COG0577	efflux transmembrane transporter activity
CXP37_18675	COG0577	efflux transmembrane transporter activity
CXP37_18685	COG4191	Histidine kinase
CXP37_18690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXP37_18720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXP37_18725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXP37_18730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXP37_18745	COG0356	it plays a direct role in the translocation of protons across the membrane
CXP37_18765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXP37_18775	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXP37_18820	COG2011	ABC-type metal ion transport system permease component
CXP37_18825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CXP37_18830	COG0697	spore germination
CXP37_18835	COG1666	GTP binding
CXP37_18845	COG0784	Response regulator, receiver
CXP37_18845	COG2198	Histidine kinase
CXP37_18845	COG5002	protein histidine kinase activity
CXP37_18865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXP37_18870	COG1187	pseudouridine synthase activity
CXP37_18875	COG2813	Specifically methylates the guanine in position
CXP37_18905	COG2202	Pas domain
CXP37_18905	COG2205	protein histidine kinase activity
CXP37_18925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXP37_18930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXP37_18935	COG1522	sequence-specific DNA binding
CXP37_18975	COG0745	RESPONSE REGULATOR receiver
CXP37_18990	COG1404	Belongs to the peptidase S8 family
CXP37_19015	COG0842	Transport permease protein
CXP37_19020	COG1131	(ABC) transporter
CXP37_19025	COG0025	NhaP-type Na H and K H
CXP37_19035	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CXP37_19040	COG1573	uracil-dna glycosylase
CXP37_19055	COG3384	dioxygenase
CXP37_19065	COG0583	DNA-binding transcription factor activity
CXP37_19075	COG0667	Aldo Keto reductase
CXP37_19085	COG3590	peptidase
CXP37_19100	COG0531	amino acid
CXP37_19115	COG2972	Histidine kinase
CXP37_19140	COG3685	Protein conserved in bacteria
CXP37_19145	COG3546	catalase activity
CXP37_19195	COG1271	oxidase subunit
CXP37_19200	COG1294	oxidase, subunit
CXP37_19215	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_19220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CXP37_19240	COG1132	(ABC) transporter
CXP37_19255	COG1063	alcohol dehydrogenase
CXP37_19345	COG0038	chloride channel
CXP37_19355	COG0024	Methionine aminopeptidase
CXP37_19375	COG3039	Transposase
CXP37_19420	COG3039	Transposase
CXP37_19470	COG0582	viral genome integration into host DNA
CXP37_19485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXP37_19490	COG1490	D-aminoacyl-tRNA deacylase activity
CXP37_19495	COG1560	Kdo2-lipid A biosynthetic process
CXP37_19540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXP37_19540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXP37_19545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXP37_19550	COG0242	peptide deformylase activity
CXP37_19555	COG1652	LysM domain
CXP37_19560	COG0758	DNA mediated transformation
CXP37_19580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXP37_19580	COG1754	DNA topoisomerase type I activity
CXP37_19600	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_19610	COG0616	signal peptide processing
CXP37_19615	COG0534	Mate efflux family protein
CXP37_19635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXP37_19640	COG0625	glutathione transferase activity
CXP37_19655	COG1252	NADH dehydrogenase
CXP37_19660	COG2860	membrane
CXP37_19665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXP37_19675	COG3437	response regulator, receiver
CXP37_19680	COG2177	Part of the ABC transporter FtsEX involved in
CXP37_19685	COG2884	Cell division ATP-binding protein ftsE
CXP37_19695	COG3118	belongs to the thioredoxin family
CXP37_19700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CXP37_19760	COG1518	maintenance of DNA repeat elements
CXP37_19765	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CXP37_19785	COG1652	LysM domain
CXP37_19790	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXP37_19790	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXP37_19805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXP37_19825	COG5383	Protein conserved in bacteria
CXP37_19870	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CXP37_19875	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXP37_19885	COG4948	Mandelate Racemase Muconate Lactonizing
CXP37_19895	COG0531	amino acid
CXP37_19910	COG4682	membrane
CXP37_19915	COG2133	pyrroloquinoline quinone binding
CXP37_19925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CXP37_19935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CXP37_19940	COG1610	YqeY-like protein
CXP37_19945	COG1295	ribonuclease BN
CXP37_19950	COG0358	DNA primase activity
CXP37_19965	COG0109	protoheme IX farnesyltransferase activity
CXP37_19995	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CXP37_20010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXP37_20060	COG0739	heme binding
CXP37_20075	COG2211	Major facilitator Superfamily
CXP37_20080	COG0708	Exodeoxyribonuclease III
CXP37_20095	COG1192	Involved in chromosome partitioning
CXP37_20100	COG1475	DNA binding
CXP37_20120	COG0463	Glycosyl transferase, family 2
CXP37_20145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXP37_20155	COG0018	arginyl-trna synthetase
CXP37_20170	COG4221	oxidoreductase activity
CXP37_20190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXP37_20190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CXP37_20195	COG1166	arginine decarboxylase activity
CXP37_20200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CXP37_20230	COG3291	Pkd domain containing protein
CXP37_20230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CXP37_20245	COG0606	chelatase, subunit chli
CXP37_20260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CXP37_20285	COG1690	Belongs to the RtcB family
CXP37_20320	COG1090	epimerase
CXP37_20330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXP37_20350	COG0628	permease
CXP37_20355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CXP37_20360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXP37_20375	COG0753	catalase activity
CXP37_20390	COG2197	response regulator
CXP37_20395	COG4585	Histidine kinase
CXP37_20400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXP37_20405	COG1136	(ABC) transporter
CXP37_20430	COG0697	spore germination
CXP37_20455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXP37_20460	COG0180	Tryptophanyl-tRNA synthetase
CXP37_20465	COG3237	CsbD-like
CXP37_20510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXP37_20530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CXP37_20530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CXP37_20540	COG3228	Belongs to the MtfA family
CXP37_20555	COG2205	protein histidine kinase activity
CXP37_20560	COG0745	RESPONSE REGULATOR receiver
CXP37_20570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXP37_20695	COG0740	serine-type endopeptidase activity
CXP37_20890	COG1199	ATP-dependent helicase activity
CXP37_20905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXP37_20920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXP37_20980	COG0625	glutathione transferase activity
CXP37_21015	COG4555	ABC transporter
CXP37_21030	COG1476	TRANSCRIPTIONal
CXP37_21045	COG1230	cation diffusion facilitator family transporter
CXP37_21050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXP37_21055	COG1131	(ABC) transporter
CXP37_21060	COG0842	Transport permease protein
CXP37_21070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXP37_21095	COG1607	acyl-coa hydrolase
CXP37_21100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXP37_21120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXP37_21125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXP37_21140	COG1042	CoA-binding domain protein
CXP37_21140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CXP37_21140	COG0045	succinate-CoA ligase (ADP-forming) activity
CXP37_21150	COG2239	Acts as a magnesium transporter
CXP37_21165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CXP37_21170	COG3387	PFAM Glycoside hydrolase 15-related
CXP37_21185	COG3100	YcgL domain-containing protein
CXP37_21190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXP37_21200	COG0463	Glycosyl transferase, family 2
CXP37_21215	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_21240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXP37_21255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXP37_21315	COG1121	(ABC) transporter
CXP37_21330	COG3220	belongs to the UPF0276 family
CXP37_21455	COG3293	Transposase
CXP37_21465	COG0210	DNA helicase
CXP37_21485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXP37_21495	COG2159	amidohydrolase
CXP37_21500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXP37_21505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXP37_21515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXP37_21540	COG0357	Ribosomal RNA small subunit methyltransferase G
CXP37_21555	COG2091	lysine biosynthetic process via aminoadipic acid
CXP37_21570	COG0708	Exodeoxyribonuclease III
CXP37_21575	COG1940	carbohydrate kinase activity
CXP37_21585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXP37_21595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXP37_21600	COG3162	membrane
CXP37_21660	COG1028	Short-chain dehydrogenase reductase Sdr
CXP37_21665	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXP37_21670	COG4948	Mandelate Racemase Muconate Lactonizing
CXP37_21675	COG3254	rhamnose metabolic process
CXP37_21680	COG0738	Major facilitator superfamily
CXP37_21685	COG1414	Transcriptional regulator
CXP37_21700	COG2205	protein histidine kinase activity
CXP37_21710	COG3459	Glycosyltransferase 36 associated
CXP37_21715	COG2211	Major facilitator Superfamily
CXP37_21720	COG3265	gluconokinase activity
CXP37_21750	COG2911	Protein conserved in bacteria
CXP37_21755	COG0729	surface antigen
CXP37_21780	COG4771	TonB-dependent receptor
CXP37_21785	COG0457	Tetratricopeptide repeat
CXP37_21795	COG0752	glycyl-tRNA synthetase alpha subunit
CXP37_21800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CXP37_21815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXP37_21815	COG0519	Catalyzes the synthesis of GMP from XMP
CXP37_21825	COG0805	protein transport
CXP37_21830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXP37_21835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXP37_21845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXP37_21865	COG2974	May be involved in recombination
CXP37_21870	COG0037	tRNA processing
CXP37_21890	COG3661	Belongs to the glycosyl hydrolase 67 family
CXP37_21900	COG4948	Mandelate Racemase Muconate Lactonizing
CXP37_21910	COG1472	Belongs to the glycosyl hydrolase 3 family
CXP37_21915	COG0246	Mannitol dehydrogenase
CXP37_21980	COG3386	PFAM SMP-30 Gluconolaconase
CXP37_22005	COG1904	glucuronate isomerase
CXP37_22010	COG3693	PFAM glycoside hydrolase, family 10
CXP37_22030	COG2211	Major facilitator Superfamily
CXP37_22070	COG2937	Belongs to the GPAT DAPAT family
CXP37_22100	COG0284	orotidine-5'-phosphate decarboxylase activity
CXP37_22105	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CXP37_22110	COG3132	Protein of unknown function, DUF480
CXP37_22125	COG0210	DNA helicase
CXP37_22130	COG1435	thymidine kinase activity
CXP37_22140	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CXP37_22150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXP37_22205	COG0676	glucose-6-phosphate 1-epimerase activity
CXP37_22215	COG3012	SEC-C Motif Domain Protein
CXP37_22220	COG0730	response to heat
CXP37_22240	COG0302	gtp cyclohydrolase
CXP37_22255	COG1566	PFAM secretion protein HlyD family protein
CXP37_22265	COG1289	transmembrane transporter activity
CXP37_22270	COG0477	Major facilitator Superfamily
CXP37_22280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXP37_22325	COG0564	pseudouridine synthase activity
CXP37_22395	COG3549	Plasmid maintenance system killer
CXP37_22400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXP37_22405	COG1074	ATP-dependent DNA helicase activity
CXP37_22410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CXP37_22445	COG1127	ABC transporter
CXP37_22450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXP37_22455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXP37_22470	COG2853	Lipoprotein
CXP37_22480	COG0386	Belongs to the glutathione peroxidase family
CXP37_22490	COG1322	Protein conserved in bacteria
CXP37_22495	COG0604	alcohol dehydrogenase
CXP37_22500	COG0583	DNA-binding transcription factor activity
CXP37_22525	COG0531	amino acid
CXP37_22550	COG3706	GGDEF domain
CXP37_22550	COG0745	RESPONSE REGULATOR receiver
CXP37_22555	COG3835	regulator
CXP37_22560	COG1929	Belongs to the glycerate kinase type-1 family
CXP37_22565	COG2271	Major facilitator Superfamily
CXP37_22585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CXP37_22595	COG0861	Integral membrane protein TerC family
CXP37_22605	COG0584	glycerophosphoryl diester phosphodiesterase
CXP37_22620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXP37_22630	COG0706	membrane insertase activity
CXP37_22640	COG0230	Belongs to the bacterial ribosomal protein bL34 family