locus-tag	class	description
BI313_00120	COG1192	Involved in chromosome partitioning
BI313_00280	COG1199	ATP-dependent helicase activity
BI313_00290	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BI313_00300	COG0745	RESPONSE REGULATOR receiver
BI313_00360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BI313_00360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI313_00380	COG1525	nuclease
BI313_00475	COG0629	single-stranded DNA binding
BI313_00500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI313_00600	COG4232	protein-disulfide reductase activity
BI313_00695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI313_00720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_00725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_00740	COG0010	Belongs to the arginase family
BI313_00795	COG2132	Multicopper oxidase
BI313_00820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI313_00835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI313_00840	COG1393	Belongs to the ArsC family
BI313_00845	COG0431	NADPH-dependent FMN reductase
BI313_00850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BI313_00895	COG4644	lycopene metabolic process
BI313_01090	COG0551	DNA topoisomerase type I activity
BI313_01090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI313_01125	COG3846	protein secretion by the type IV secretion system
BI313_01135	COG3451	type IV secretory pathway VirB4
BI313_01150	COG4962	Type ii secretion system protein e
BI313_01285	COG3706	GGDEF domain
BI313_01305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI313_01315	COG2914	Belongs to the UPF0125 (RnfH) family
BI313_01320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_01330	COG0497	DNA recombination
BI313_01335	COG1420	regulation of RNA biosynthetic process
BI313_01340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI313_01355	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BI313_01385	COG0583	DNA-binding transcription factor activity
BI313_01390	COG1132	(ABC) transporter
BI313_01415	COG0567	Dehydrogenase, E1 component
BI313_01425	COG2850	peptidyl-arginine hydroxylation
BI313_01440	COG1253	flavin adenine dinucleotide binding
BI313_01470	COG1131	(ABC) transporter
BI313_01475	COG1725	Transcriptional regulator
BI313_01485	COG0386	Belongs to the glutathione peroxidase family
BI313_01505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI313_01505	COG2755	lipolytic protein G-D-S-L family
BI313_01530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_01540	COG1410	methionine synthase
BI313_01540	COG0646	methionine synthase
BI313_01545	COG1410	methionine synthase
BI313_01545	COG0646	methionine synthase
BI313_01555	COG1960	acyl-CoA dehydrogenase activity
BI313_01570	COG0557	exoribonuclease II activity
BI313_01580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI313_01585	COG3706	GGDEF domain
BI313_01590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI313_01600	COG0704	Plays a role in the regulation of phosphate uptake
BI313_01605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI313_01610	COG0581	inorganic phosphate transmembrane transporter activity
BI313_01615	COG0573	inorganic phosphate transmembrane transporter activity
BI313_01620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI313_01645	COG0659	secondary active sulfate transmembrane transporter activity
BI313_01650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI313_01660	COG1024	Enoyl-CoA hydratase
BI313_01670	COG0494	nUDIX hydrolase
BI313_01755	COG2925	Exonuclease
BI313_01760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_01765	COG3844	kynureninase activity
BI313_01780	COG0288	reversible hydration of carbon dioxide
BI313_01805	COG0017	Asparaginyl-tRNA synthetase
BI313_01810	COG0316	Belongs to the HesB IscA family
BI313_01835	COG3115	cell septum assembly
BI313_01845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI313_01850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI313_01880	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BI313_01890	COG4993	Dehydrogenase
BI313_01905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI313_01915	COG2986	histidine ammonia-lyase
BI313_01920	COG1228	amidohydrolase
BI313_01955	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BI313_01960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI313_01965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BI313_01970	COG0077	Prephenate dehydratase
BI313_01970	COG1605	Chorismate mutase
BI313_01975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI313_01990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI313_01995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI313_02000	COG0583	DNA-binding transcription factor activity
BI313_02040	COG1122	ATPase activity
BI313_02070	COG2003	Belongs to the UPF0758 family
BI313_02105	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BI313_02240	COG0840	transmembrane signaling receptor activity
BI313_02255	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BI313_02260	COG0784	Response regulator, receiver
BI313_02260	COG4191	Histidine kinase
BI313_02275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_02285	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BI313_02295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI313_02310	COG1595	DNA-templated transcription, initiation
BI313_02345	COG2244	polysaccharide biosynthetic process
BI313_02380	COG4106	trans-aconitate 2-methyltransferase activity
BI313_02390	COG0438	transferase activity, transferring glycosyl groups
BI313_02410	COG1132	(ABC) transporter
BI313_02415	COG0477	Major facilitator Superfamily
BI313_02420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI313_02435	COG1253	flavin adenine dinucleotide binding
BI313_02455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BI313_02465	COG2134	cdp-diacylglycerol pyrophosphatase
BI313_02480	COG0504	CTP synthase activity
BI313_02495	COG0148	phosphopyruvate hydratase activity
BI313_02500	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BI313_02510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BI313_02515	COG0585	pseudouridine synthase activity
BI313_02520	COG2840	Smr protein MutS2
BI313_02525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BI313_02530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI313_02535	COG1238	metal cluster binding
BI313_02545	COG3737	Protein of unknown function (DUF498/DUF598)
BI313_02550	COG1534	Rna-binding protein
BI313_02555	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BI313_02560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI313_02565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BI313_02570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI313_02575	COG1923	regulation of RNA biosynthetic process
BI313_02580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI313_02585	COG1546	Belongs to the CinA family
BI313_02590	COG4771	TonB-dependent receptor
BI313_02595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI313_02600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI313_02610	COG2137	regulation of response to DNA damage stimulus
BI313_02615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI313_02620	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BI313_02635	COG1741	Belongs to the pirin family
BI313_02640	COG0583	DNA-binding transcription factor activity
BI313_02665	COG0351	phosphomethylpyrimidine kinase
BI313_02665	COG0352	thiamine-phosphate diphosphorylase activity
BI313_02680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BI313_02685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI313_02700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI313_02710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BI313_02715	COG3734	2-keto-3-deoxy-galactonokinase
BI313_02730	COG0800	Aldolase
BI313_02770	COG1501	Belongs to the glycosyl hydrolase 31 family
BI313_02780	COG1070	Carbohydrate kinase
BI313_02785	COG2115	Belongs to the xylose isomerase family
BI313_02790	COG0477	Major facilitator Superfamily
BI313_02810	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI313_02825	COG0617	tRNA 3'-terminal CCA addition
BI313_02840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BI313_02845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BI313_02880	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_02895	COG5001	Diguanylate cyclase
BI313_02895	COG4251	negative regulation of phosphorylation
BI313_02895	COG3706	GGDEF domain
BI313_02895	COG2203	Gaf domain
BI313_02905	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BI313_02915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BI313_02920	COG0671	phosphoesterase, PA-phosphatase related
BI313_02930	COG1794	racemase activity, acting on amino acids and derivatives
BI313_02935	COG0697	spore germination
BI313_02940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI313_02960	COG1012	belongs to the aldehyde dehydrogenase family
BI313_02995	COG2003	Belongs to the UPF0758 family
BI313_03015	COG3220	belongs to the UPF0276 family
BI313_03100	COG0840	transmembrane signaling receptor activity
BI313_03105	COG0840	transmembrane signaling receptor activity
BI313_03115	COG1215	transferase activity, transferring glycosyl groups
BI313_03120	COG0726	polysaccharide deacetylase
BI313_03120	COG1649	PFAM Uncharacterised BCR, COG1649
BI313_03150	COG2963	transposase activity
BI313_03155	COG2801	Transposase and inactivated derivatives
BI313_03200	COG2801	Transposase and inactivated derivatives
BI313_03205	COG2963	transposase activity
BI313_03235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BI313_03245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI313_03250	COG0124	histidyl-tRNA synthetase
BI313_03265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI313_03270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI313_03275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BI313_03275	COG0131	Imidazoleglycerol-phosphate dehydratase
BI313_03280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI313_03285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI313_03290	COG0107	imidazoleglycerol-phosphate synthase activity
BI313_03295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BI313_03295	COG0140	phosphoribosyl-ATP diphosphatase activity
BI313_03315	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BI313_03320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BI313_03335	COG0531	amino acid
BI313_03340	COG0531	amino acid
BI313_03350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI313_03355	COG0277	FAD linked oxidase domain protein
BI313_03375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI313_03395	COG1024	Enoyl-CoA hydratase
BI313_03420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI313_03425	COG2258	MOSC domain
BI313_03435	COG0505	Belongs to the CarA family
BI313_03445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI313_03450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI313_03460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI313_03475	COG3279	Response regulator of the LytR AlgR family
BI313_03480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BI313_03485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI313_03500	COG0784	Response regulator, receiver
BI313_03500	COG2198	Histidine kinase
BI313_03500	COG2205	protein histidine kinase activity
BI313_03505	COG1024	Enoyl-CoA hydratase
BI313_03510	COG0318	PFAM AMP-dependent synthetase and ligase
BI313_03540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_03550	COG2201	protein-glutamate methylesterase activity
BI313_03565	COG0840	transmembrane signaling receptor activity
BI313_03575	COG0835	chemotaxis
BI313_03590	COG0840	transmembrane signaling receptor activity
BI313_03600	COG0840	transmembrane signaling receptor activity
BI313_03605	COG0840	transmembrane signaling receptor activity
BI313_03610	COG0840	transmembrane signaling receptor activity
BI313_03630	COG0840	transmembrane signaling receptor activity
BI313_03645	COG2198	Histidine kinase
BI313_03645	COG0643	Histidine kinase
BI313_03650	COG0745	RESPONSE REGULATOR receiver
BI313_03660	COG0835	chemotaxis
BI313_03665	COG1192	Involved in chromosome partitioning
BI313_03675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BI313_03755	COG0643	Histidine kinase
BI313_03755	COG2198	Histidine kinase
BI313_03775	COG0455	bacterial-type flagellum organization
BI313_03800	COG3300	MHYT domain
BI313_03800	COG5001	Diguanylate cyclase
BI313_03810	COG1987	bacterial-type flagellum assembly
BI313_03870	COG1677	Flagellar hook-basal body complex protein FliE
BI313_03925	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_03945	COG2204	response regulator
BI313_03950	COG2201	protein-glutamate methylesterase activity
BI313_03980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BI313_03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI313_03990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BI313_04000	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI313_04000	COG3951	Flagellar rod assembly protein muramidase FlgJ
BI313_04015	COG4786	Flagellar basal body rod
BI313_04030	COG4787	bacterial-type flagellum-dependent cell motility
BI313_04035	COG1749	Flagellar hook protein flgE
BI313_04040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BI313_04045	COG1558	bacterial-type flagellum-dependent cell motility
BI313_04050	COG1815	bacterial-type flagellum-dependent cell motility
BI313_04055	COG0784	Response regulator, receiver
BI313_04055	COG0835	chemotaxis
BI313_04075	COG4191	Histidine kinase
BI313_04115	COG0482	sulfurtransferase activity
BI313_04130	COG0542	response to heat
BI313_04140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BI313_04155	COG0492	ferredoxin-NADP+ reductase activity
BI313_04160	COG1674	ftsk spoiiie
BI313_04175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI313_04180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI313_04185	COG0183	Belongs to the thiolase family
BI313_04190	COG1024	Enoyl-CoA hydratase
BI313_04190	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI313_04200	COG0105	UTP biosynthetic process
BI313_04215	COG1426	Protein conserved in bacteria
BI313_04225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_04230	COG1160	GTP binding
BI313_04240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI313_04255	COG0708	Exodeoxyribonuclease III
BI313_04270	COG0746	molybdenum cofactor guanylyltransferase activity
BI313_04280	COG1648	precorrin-2 dehydrogenase activity
BI313_04280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI313_04290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BI313_04300	COG2223	nitrite transmembrane transporter activity
BI313_04305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI313_04310	COG2146	nitrite reductase [NAD(P)H] activity
BI313_04315	COG0243	molybdopterin cofactor binding
BI313_04330	COG3685	Protein conserved in bacteria
BI313_04340	COG5001	Diguanylate cyclase
BI313_04410	COG1238	metal cluster binding
BI313_04420	COG3226	Transcriptional regulator
BI313_04430	COG2223	nitrite transmembrane transporter activity
BI313_04435	COG4221	oxidoreductase activity
BI313_04460	COG0363	glucosamine-6-phosphate deaminase activity
BI313_04480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI313_04485	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_04500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI313_04510	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_04515	COG0583	DNA-binding transcription factor activity
BI313_04530	COG2369	cell adhesion
BI313_04595	COG5599	Phosphatase
BI313_04735	COG2154	pterin-4-alpha-carbinolamine dehydratase
BI313_04745	COG0428	transporter
BI313_04760	COG1530	ribonuclease E activity
BI313_04790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BI313_04830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI313_04835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BI313_04840	COG1663	tetraacyldisaccharide 4'-kinase activity
BI313_04845	COG1132	(ABC) transporter
BI313_04855	COG0811	peptide transport
BI313_04880	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI313_04890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BI313_04895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI313_04910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BI313_04925	COG0354	folic acid binding
BI313_04935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI313_04940	COG0837	glucose binding
BI313_04945	COG0363	glucosamine-6-phosphate deaminase activity
BI313_04950	COG0129	dihydroxy-acid dehydratase activity
BI313_04955	COG0800	Aldolase
BI313_05020	COG2205	protein histidine kinase activity
BI313_05020	COG5002	protein histidine kinase activity
BI313_05020	COG0784	Response regulator, receiver
BI313_05025	COG2183	response to ionizing radiation
BI313_05050	COG3243	poly(R)-hydroxyalkanoic acid synthase
BI313_05060	COG1183	phosphatidylcholine synthase activity
BI313_05065	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_05090	COG0668	transmembrane transport
BI313_05095	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BI313_05100	COG0590	tRNA wobble adenosine to inosine editing
BI313_05105	COG1321	iron dependent repressor
BI313_05110	COG1914	H( )-stimulated, divalent metal cation uptake system
BI313_05135	COG2814	Major facilitator Superfamily
BI313_05150	COG1335	isochorismatase
BI313_05160	COG4585	Histidine kinase
BI313_05165	COG2197	response regulator
BI313_05190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI313_05205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI313_05205	COG0475	glutathione-regulated potassium exporter activity
BI313_05210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BI313_05220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI313_05225	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BI313_05235	COG0776	regulation of translation
BI313_05245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI313_05250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BI313_05260	COG2957	Belongs to the agmatine deiminase family
BI313_05265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI313_05290	COG0395	ABC-type sugar transport system, permease component
BI313_05295	COG1175	transmembrane transport
BI313_05300	COG1653	transport
BI313_05325	COG2350	Protein conserved in bacteria
BI313_05330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI313_05335	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI313_05340	COG1187	pseudouridine synthase activity
BI313_05355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI313_05365	COG0436	Aminotransferase
BI313_05370	COG4133	protoheme IX ABC transporter activity
BI313_05425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_05435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI313_05440	COG4988	ABC transporter
BI313_05450	COG1294	oxidase, subunit
BI313_05475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BI313_05495	COG0165	Argininosuccinate lyase
BI313_05510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI313_05515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI313_05525	COG0137	argininosuccinate synthase activity
BI313_05535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI313_05545	COG0215	cysteine-tRNA ligase activity
BI313_05550	COG2166	iron-sulfur cluster assembly
BI313_05560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI313_05570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI313_05590	COG4302	ethanolamine ammonia-lyase activity
BI313_05610	COG4677	pectinesterase activity
BI313_05630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BI313_05635	COG0402	S-adenosylhomocysteine deaminase activity
BI313_05650	COG1509	lysine 2,3-aminomutase activity
BI313_05655	COG3300	MHYT domain
BI313_05655	COG5001	Diguanylate cyclase
BI313_05670	COG0483	inositol monophosphate 1-phosphatase activity
BI313_05695	COG0513	Belongs to the DEAD box helicase family
BI313_05705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI313_05710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BI313_05720	COG0625	glutathione transferase activity
BI313_05735	COG4681	YaeQ
BI313_05740	COG2081	HI0933 family
BI313_05750	COG0501	Belongs to the peptidase M48B family
BI313_05755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI313_05760	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_05780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI313_05785	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI313_05795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BI313_05795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI313_05800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI313_05815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI313_05850	COG0582	viral genome integration into host DNA
BI313_05870	COG2801	Transposase and inactivated derivatives
BI313_05875	COG2963	transposase activity
BI313_05900	COG0835	chemotaxis
BI313_05905	COG0840	transmembrane signaling receptor activity
BI313_05915	COG1201	RNA secondary structure unwinding
BI313_05930	COG2969	positive regulation of protein catabolic process
BI313_05935	COG0625	glutathione transferase activity
BI313_05940	COG2857	Cytochrome c1
BI313_05950	COG0723	plastoquinol--plastocyanin reductase activity
BI313_05955	COG0741	lytic transglycosylase activity
BI313_05975	COG1702	phosphate starvation-inducible protein PhoH
BI313_05985	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI313_05995	COG4535	Mg2 and Co2 transporter CorC
BI313_06010	COG1012	belongs to the aldehyde dehydrogenase family
BI313_06020	COG1177	transmembrane transport
BI313_06025	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI313_06030	COG3842	ATPase activity
BI313_06050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BI313_06070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI313_06075	COG0174	glutamine synthetase
BI313_06080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_06085	COG0745	RESPONSE REGULATOR receiver
BI313_06085	COG3706	GGDEF domain
BI313_06095	COG2703	oxygen carrier activity
BI313_06100	COG0477	Major facilitator Superfamily
BI313_06115	COG0243	molybdopterin cofactor binding
BI313_06120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI313_06140	COG2733	membrane
BI313_06145	COG2205	protein histidine kinase activity
BI313_06145	COG0784	Response regulator, receiver
BI313_06145	COG5002	protein histidine kinase activity
BI313_06155	COG0477	Major facilitator Superfamily
BI313_06170	COG2902	Dehydrogenase
BI313_06180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_06185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_06200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI313_06200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI313_06205	COG1105	Belongs to the carbohydrate kinase PfkB family
BI313_06210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI313_06210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI313_06225	COG2963	transposase activity
BI313_06230	COG2801	Transposase and inactivated derivatives
BI313_06255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI313_06265	COG1862	Preprotein translocase
BI313_06270	COG0343	queuine tRNA-ribosyltransferase activity
BI313_06275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BI313_06315	COG3291	Pkd domain containing protein
BI313_06320	COG0405	Gamma-glutamyltransferase
BI313_06325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BI313_06340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI313_06345	COG0742	ribosomal rna small subunit methyltransferase
BI313_06400	COG0531	amino acid
BI313_06420	COG0006	proline dipeptidase activity
BI313_06430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI313_06445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_06450	COG3938	Belongs to the proline racemase family
BI313_06460	COG0552	protein localization to endoplasmic reticulum
BI313_06480	COG0784	Response regulator, receiver
BI313_06480	COG4191	Histidine kinase
BI313_06525	COG1960	acyl-CoA dehydrogenase activity
BI313_06535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BI313_06555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI313_06565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI313_06605	COG0438	transferase activity, transferring glycosyl groups
BI313_06610	COG0438	transferase activity, transferring glycosyl groups
BI313_06655	COG0776	regulation of translation
BI313_06660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI313_06660	COG0072	phenylalanine-tRNA ligase activity
BI313_06665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI313_06670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BI313_06675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BI313_06680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI313_06685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI313_06710	COG1082	Xylose isomerase domain protein TIM barrel
BI313_06725	COG0366	Alpha amylase catalytic
BI313_06735	COG3702	type iv secretory pathway
BI313_06755	COG2948	multi-organism process
BI313_06775	COG3505	Type IV secretory pathway VirD4
BI313_06835	COG1611	Belongs to the LOG family
BI313_06845	COG2095	MarC family integral membrane protein
BI313_06855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI313_06895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI313_06900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI313_06905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI313_06915	COG0195	Participates in both transcription termination and antitermination
BI313_06920	COG0779	Required for maturation of 30S ribosomal subunits
BI313_06930	COG1007	ATP synthesis coupled electron transport
BI313_06945	COG0713	ATP synthesis coupled electron transport
BI313_06965	COG1034	ATP synthesis coupled electron transport
BI313_06970	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BI313_06975	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BI313_06980	COG0649	NAD binding
BI313_06985	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI313_06995	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BI313_07010	COG0149	triose-phosphate isomerase activity
BI313_07050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI313_07070	COG0133	tryptophan synthase activity
BI313_07080	COG0135	phosphoribosylanthranilate isomerase activity
BI313_07085	COG0101	tRNA pseudouridine synthase activity
BI313_07100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI313_07105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI313_07110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI313_07120	COG2890	protein-(glutamine-N5) methyltransferase activity
BI313_07130	COG0688	phosphatidylethanolamine metabolic process
BI313_07140	COG0741	lytic transglycosylase activity
BI313_07145	COG0433	COG0433 Predicted ATPase
BI313_07155	COG0494	nUDIX hydrolase
BI313_07170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI313_07200	COG0717	Belongs to the dCTP deaminase family
BI313_07210	COG0489	protein tyrosine kinase activity
BI313_07225	COG3590	peptidase
BI313_07230	COG3590	peptidase
BI313_07250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI313_07255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_07260	COG2311	Membrane
BI313_07265	COG1047	Peptidyl-prolyl cis-trans
BI313_07270	COG0791	NLP P60 protein
BI313_07275	COG0791	NLP P60 protein
BI313_07320	COG2226	methyltransferase
BI313_07325	COG1301	dicarboxylic acid transport
BI313_07330	COG1785	Belongs to the alkaline phosphatase family
BI313_07335	COG0037	tRNA processing
BI313_07340	COG1722	exodeoxyribonuclease VII activity
BI313_07345	COG0142	geranyltranstransferase activity
BI313_07355	COG4104	PAAR repeat-containing protein
BI313_07365	COG0312	modulator of DNA gyrase
BI313_07370	COG3028	Belongs to the UPF0307 family
BI313_07375	COG0312	modulator of DNA gyrase
BI313_07390	COG1530	ribonuclease E activity
BI313_07395	COG0424	maF-like protein
BI313_07400	COG2968	Membrane
BI313_07430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BI313_07445	COG0495	leucyl-tRNA aminoacylation
BI313_07455	COG3118	belongs to the thioredoxin family
BI313_07465	COG2155	Conserved Protein
BI313_07520	COG1132	(ABC) transporter
BI313_07530	COG0475	glutathione-regulated potassium exporter activity
BI313_07540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI313_07570	COG3706	GGDEF domain
BI313_07575	COG1187	pseudouridine synthase activity
BI313_07580	COG5001	Diguanylate cyclase
BI313_07580	COG5002	protein histidine kinase activity
BI313_07600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_07695	COG0667	Aldo Keto reductase
BI313_07700	COG2814	Major facilitator Superfamily
BI313_07705	COG0583	DNA-binding transcription factor activity
BI313_07715	COG2207	Transcriptional regulator
BI313_07730	COG0667	Aldo Keto reductase
BI313_07735	COG1309	transcriptional regulator
BI313_07740	COG1538	Outer membrane efflux protein
BI313_07760	COG0735	belongs to the Fur family
BI313_07790	COG4452	Inner membrane protein CreD
BI313_07795	COG2205	protein histidine kinase activity
BI313_07800	COG0745	RESPONSE REGULATOR receiver
BI313_07805	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BI313_07825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI313_07835	COG0643	Histidine kinase
BI313_07835	COG2198	Histidine kinase
BI313_07840	COG0840	transmembrane signaling receptor activity
BI313_07845	COG0835	chemotaxis
BI313_07870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_07875	COG3590	peptidase
BI313_07885	COG0588	phosphoglycerate mutase activity
BI313_07890	COG1515	deoxyribonuclease V activity
BI313_07905	COG1741	Belongs to the pirin family
BI313_07920	COG1741	Belongs to the pirin family
BI313_07925	COG1966	Carbon starvation protein
BI313_07930	COG2879	small protein
BI313_07975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BI313_07980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI313_07990	COG2080	2 iron, 2 sulfur cluster binding
BI313_07995	COG3321	synthase
BI313_07995	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_07995	COG0604	alcohol dehydrogenase
BI313_08005	COG0629	single-stranded DNA binding
BI313_08010	COG0142	geranyltranstransferase activity
BI313_08020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI313_08035	COG0527	aspartate kinase activity
BI313_08040	COG0384	phenazine biosynthesis protein PhzF
BI313_08045	COG0384	phenazine biosynthesis protein PhzF
BI313_08055	COG1764	response to oxidative stress
BI313_08065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI313_08070	COG1678	Uncharacterized ACR, COG1678
BI313_08075	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BI313_08080	COG0519	Catalyzes the synthesis of GMP from XMP
BI313_08110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI313_08150	COG0693	protein deglycase activity
BI313_08160	COG1959	2 iron, 2 sulfur cluster binding
BI313_08165	COG0719	Fe-S assembly protein
BI313_08170	COG0396	ATPase activity
BI313_08175	COG0719	Fe-S assembly protein
BI313_08180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BI313_08190	COG0456	acetyltransferase
BI313_08200	COG4774	siderophore transport
BI313_08235	COG1477	protein flavinylation
BI313_08250	COG1555	photosystem II stabilization
BI313_08255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI313_08270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BI313_08280	COG0628	permease
BI313_08290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI313_08305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BI313_08345	COG0271	Belongs to the BolA IbaG family
BI313_08355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BI313_08365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BI313_08370	COG1137	ATPase activity
BI313_08385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI313_08395	COG1660	Displays ATPase and GTPase activities
BI313_08405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI313_08410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI313_08415	COG2239	Acts as a magnesium transporter
BI313_08425	COG1294	oxidase, subunit
BI313_08430	COG1271	oxidase subunit
BI313_08435	COG1113	amino acid transport
BI313_08450	COG2197	response regulator
BI313_08455	COG0531	amino acid
BI313_08505	COG2814	Major facilitator Superfamily
BI313_08510	COG0754	glutathionylspermidine amidase activity
BI313_08535	COG1842	Phage shock protein A
BI313_08555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI313_08570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI313_08575	COG2814	Major facilitator Superfamily
BI313_08595	COG2353	YceI-like domain
BI313_08610	COG1278	Cold shock
BI313_08625	COG1760	l-serine dehydratase
BI313_08635	COG0527	aspartate kinase activity
BI313_08635	COG0460	homoserine dehydrogenase
BI313_08640	COG0626	cystathionine gamma-synthase activity
BI313_08645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_08650	COG0739	heme binding
BI313_08655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI313_08660	COG1272	protein, Hemolysin III
BI313_08665	COG2982	Protein involved in outer membrane biogenesis
BI313_08670	COG0517	IMP dehydrogenase activity
BI313_08670	COG0516	GMP reductase activity
BI313_08680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI313_08685	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI313_08695	COG4771	TonB-dependent receptor
BI313_08700	COG1309	transcriptional regulator
BI313_08710	COG1960	acyl-CoA dehydrogenase activity
BI313_08740	COG0509	glycine decarboxylation via glycine cleavage system
BI313_08745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI313_08755	COG0330	HflC and HflK could
BI313_08765	COG3956	TIGRFAM MazG family protein
BI313_08770	COG1218	3'(2'),5'-bisphosphate nucleotidase
BI313_08775	COG0494	nUDIX hydrolase
BI313_08785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI313_08805	COG3858	chitin binding
BI313_08805	COG1388	LysM domain
BI313_08810	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BI313_08820	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_08830	COG3537	Alpha-1,2-mannosidase
BI313_08870	COG3142	Participates in the control of copper homeostasis
BI313_08875	COG1446	asparaginase
BI313_08880	COG2304	oxidoreductase activity
BI313_08915	COG0840	transmembrane signaling receptor activity
BI313_08920	COG0835	chemotaxis
BI313_08935	COG0189	ligase activity
BI313_08945	COG1397	ADP-ribosylglycohydrolase
BI313_08955	COG1199	ATP-dependent helicase activity
BI313_08965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI313_08970	COG1216	Glycosyl transferase, family 2
BI313_08980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI313_08990	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI313_08995	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
BI313_09020	COG0837	glucose binding
BI313_09030	COG1643	Atp-dependent helicase
BI313_09035	COG0783	Belongs to the Dps family
BI313_09040	COG0514	ATP-dependent DNA helicase (RecQ)
BI313_09060	COG1187	pseudouridine synthase activity
BI313_09070	COG0840	transmembrane signaling receptor activity
BI313_09080	COG3920	Histidine kinase
BI313_09080	COG2202	Pas domain
BI313_09100	COG0602	queuosine metabolic process
BI313_09110	COG2885	chlorophyll binding
BI313_09115	COG0823	Involved in the tonB-independent uptake of proteins
BI313_09125	COG0848	biopolymer transport protein
BI313_09135	COG0824	Thioesterase
BI313_09140	COG2255	four-way junction helicase activity
BI313_09155	COG0632	four-way junction helicase activity
BI313_09160	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BI313_09180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI313_09200	COG0477	Major facilitator Superfamily
BI313_09220	COG0640	Transcriptional regulator
BI313_09225	COG0730	response to heat
BI313_09250	COG2755	lipolytic protein G-D-S-L family
BI313_09250	COG0657	acetylesterase activity
BI313_09265	COG2951	lytic endotransglycosylase activity
BI313_09275	COG0488	(ABC) transporter
BI313_09310	COG4651	solute:proton antiporter activity
BI313_09310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI313_09320	COG4772	TonB-dependent receptor
BI313_09330	COG4264	IucA IucC family
BI313_09335	COG2814	Major facilitator Superfamily
BI313_09340	COG4264	IucA IucC family
BI313_09345	COG0019	diaminopimelate decarboxylase activity
BI313_09365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BI313_09375	COG1492	cobalamin metabolic process
BI313_09385	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI313_09405	COG4206	TonB-dependent receptor
BI313_09415	COG0542	response to heat
BI313_09465	COG3387	PFAM Glycoside hydrolase 15-related
BI313_09475	COG4993	Dehydrogenase
BI313_09480	COG0840	transmembrane signaling receptor activity
BI313_09485	COG3011	Protein conserved in bacteria
BI313_09500	COG0564	pseudouridine synthase activity
BI313_09505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_09515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BI313_09515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI313_09530	COG0045	succinate-CoA ligase (ADP-forming) activity
BI313_09585	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BI313_09590	COG0237	dephospho-CoA kinase activity
BI313_09600	COG0745	RESPONSE REGULATOR receiver
BI313_09610	COG0189	ligase activity
BI313_09645	COG1074	ATP-dependent DNA helicase activity
BI313_09865	COG2003	Belongs to the UPF0758 family
BI313_09950	COG0471	metal ion transport
BI313_09950	COG3273	potassium ion transport
BI313_09970	COG1970	mechanosensitive ion channel activity
BI313_09980	COG1609	Transcriptional regulator
BI313_09995	COG5297	Belongs to the glycosyl hydrolase family 6
BI313_10005	COG3250	beta-galactosidase activity
BI313_10010	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_10015	COG2272	Belongs to the type-B carboxylesterase lipase family
BI313_10020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI313_10025	COG1115	amino acid carrier protein
BI313_10040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_10045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_10050	COG2895	sulfate adenylyltransferase (ATP) activity
BI313_10050	COG0529	Catalyzes the synthesis of activated sulfate
BI313_10060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI313_10065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI313_10090	COG0784	Response regulator, receiver
BI313_10090	COG2198	Histidine kinase
BI313_10090	COG2205	protein histidine kinase activity
BI313_10105	COG1648	precorrin-2 dehydrogenase activity
BI313_10105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI313_10120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BI313_10125	COG3588	fructose-bisphosphate aldolase
BI313_10135	COG0469	pyruvate kinase activity
BI313_10165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BI313_10185	COG3047	cAMP biosynthetic process
BI313_10195	COG3453	Protein conserved in bacteria
BI313_10195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI313_10200	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI313_10205	COG4149	molybdate abc transporter
BI313_10210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI313_10245	COG1376	ErfK ybiS ycfS ynhG family protein
BI313_10250	COG0739	heme binding
BI313_10260	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_10265	COG0583	DNA-binding transcription factor activity
BI313_10270	COG4773	Receptor
BI313_10275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI313_10280	COG1301	dicarboxylic acid transport
BI313_10290	COG2304	oxidoreductase activity
BI313_10310	COG0714	Associated with various cellular activities
BI313_10340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BI313_10355	COG0254	rRNA binding
BI313_10365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BI313_10375	COG2721	sulfolactate sulfo-lyase activity
BI313_10390	COG2271	Major facilitator Superfamily
BI313_10405	COG0583	DNA-binding transcription factor activity
BI313_10415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BI313_10420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI313_10425	COG2390	Transcriptional regulator
BI313_10435	COG3659	wide pore channel activity
BI313_10440	COG4209	transmembrane transport
BI313_10455	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_10465	COG1758	RNA polymerase activity
BI313_10475	COG1561	YicC-like family, N-terminal region
BI313_10480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BI313_10490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BI313_10495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI313_10510	COG0006	proline dipeptidase activity
BI313_10525	COG0006	proline dipeptidase activity
BI313_10550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI313_10570	COG2912	Transglutaminase-like superfamily
BI313_10575	COG1773	rubredoxin
BI313_10580	COG0352	thiamine-phosphate diphosphorylase activity
BI313_10660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BI313_10785	COG2963	transposase activity
BI313_10790	COG2801	Transposase and inactivated derivatives
BI313_10800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI313_10815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI313_10845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI313_10850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI313_10880	COG0671	phosphoesterase, PA-phosphatase related
BI313_10885	COG3781	membrane
BI313_10895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI313_10900	COG0563	adenylate kinase activity
BI313_11020	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BI313_11030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BI313_11050	COG3710	Transcriptional regulator
BI313_11065	COG0840	transmembrane signaling receptor activity
BI313_11095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI313_11105	COG0473	3-isopropylmalate dehydrogenase activity
BI313_11110	COG2226	methyltransferase
BI313_11115	COG0066	3-isopropylmalate dehydratase activity
BI313_11140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BI313_11145	COG1538	Outer membrane efflux protein
BI313_11155	COG1519	Transferase
BI313_11160	COG1560	Kdo2-lipid A biosynthetic process
BI313_11185	COG0281	malic enzyme
BI313_11185	COG0280	phosphate acetyltransferase
BI313_11200	COG4191	Histidine kinase
BI313_11210	COG0667	Aldo Keto reductase
BI313_11225	COG2197	response regulator
BI313_11230	COG1840	ABC-type Fe3 transport system, periplasmic component
BI313_11235	COG0642	Histidine kinase
BI313_11250	COG2851	Citrate transporter
BI313_11255	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_11260	COG1609	Transcriptional regulator
BI313_11265	COG2211	Major facilitator Superfamily
BI313_11295	COG0436	Aminotransferase
BI313_11310	COG0726	polysaccharide deacetylase
BI313_11315	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BI313_11330	COG3964	amidohydrolase
BI313_11335	COG0402	S-adenosylhomocysteine deaminase activity
BI313_11375	COG1307	EDD domain protein, DegV family
BI313_11390	COG3791	Glutathione-dependent formaldehyde-activating
BI313_11405	COG0583	DNA-binding transcription factor activity
BI313_11420	COG0745	RESPONSE REGULATOR receiver
BI313_11425	COG2205	protein histidine kinase activity
BI313_11455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI313_11470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI313_11480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI313_11485	COG1012	belongs to the aldehyde dehydrogenase family
BI313_11490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI313_11540	COG1183	phosphatidylcholine synthase activity
BI313_11565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI313_11570	COG1127	ABC transporter
BI313_11575	COG3218	ABC-type transport auxiliary lipoprotein component
BI313_11575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI313_11615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI313_11620	COG0662	Cupin 2, conserved barrel domain protein
BI313_11620	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BI313_11650	COG2086	electron transfer activity
BI313_11660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BI313_11665	COG0463	Glycosyl transferase, family 2
BI313_11705	COG1682	transport, permease protein
BI313_11710	COG0626	cystathionine gamma-synthase activity
BI313_11745	COG0625	glutathione transferase activity
BI313_11760	COG0513	Belongs to the DEAD box helicase family
BI313_11765	COG0720	synthase
BI313_11780	COG1956	GAF domain-containing protein
BI313_11795	COG0546	phosphoglycolate phosphatase activity
BI313_11805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI313_11825	COG0339	signal peptide processing
BI313_11885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI313_11890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_11895	COG1136	(ABC) transporter
BI313_11895	COG4591	ABC-type transport system involved in lipoprotein release permease component
BI313_11915	COG2204	response regulator
BI313_11920	COG4191	Histidine kinase
BI313_11930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI313_11945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI313_11955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI313_11965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI313_11970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI313_11980	COG0356	it plays a direct role in the translocation of protons across the membrane
BI313_11995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI313_12005	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI313_12035	COG2011	ABC-type metal ion transport system permease component
BI313_12040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI313_12045	COG0697	spore germination
BI313_12050	COG1666	GTP binding
BI313_12080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI313_12085	COG1187	pseudouridine synthase activity
BI313_12090	COG2813	Specifically methylates the guanine in position
BI313_12130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI313_12135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_12140	COG1522	sequence-specific DNA binding
BI313_12190	COG0842	Transport permease protein
BI313_12195	COG1131	(ABC) transporter
BI313_12200	COG0025	NhaP-type Na H and K H
BI313_12220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BI313_12225	COG1573	uracil-dna glycosylase
BI313_12240	COG3384	dioxygenase
BI313_12245	COG0583	DNA-binding transcription factor activity
BI313_12255	COG0667	Aldo Keto reductase
BI313_12265	COG3590	peptidase
BI313_12285	COG0531	amino acid
BI313_12300	COG3275	phosphorelay sensor kinase activity
BI313_12315	COG3685	Protein conserved in bacteria
BI313_12320	COG3546	catalase activity
BI313_12350	COG2204	response regulator
BI313_12370	COG1294	oxidase, subunit
BI313_12395	COG1063	alcohol dehydrogenase
BI313_12425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI313_12480	COG0251	oxidation-reduction process
BI313_12515	COG0038	chloride channel
BI313_12525	COG0024	Methionine aminopeptidase
BI313_12535	COG1733	regulation of RNA biosynthetic process
BI313_12545	COG1999	signal sequence binding
BI313_12555	COG1335	isochorismatase
BI313_12595	COG1487	ribonuclease activity
BI313_12605	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BI313_12605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_12640	COG0419	ATPase involved in DNA repair
BI313_12700	COG1196	nuclear chromosome segregation
BI313_12755	COG0582	viral genome integration into host DNA
BI313_12770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI313_12775	COG1490	D-aminoacyl-tRNA deacylase activity
BI313_12780	COG1560	Kdo2-lipid A biosynthetic process
BI313_12785	COG1247	-acetyltransferase
BI313_12825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI313_12825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI313_12830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI313_12835	COG0242	peptide deformylase activity
BI313_12840	COG1652	LysM domain
BI313_12845	COG0758	DNA mediated transformation
BI313_12865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI313_12865	COG1754	DNA topoisomerase type I activity
BI313_12870	COG0009	L-threonylcarbamoyladenylate synthase
BI313_12885	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_12895	COG0616	signal peptide processing
BI313_12900	COG0534	Mate efflux family protein
BI313_12920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI313_12925	COG0625	glutathione transferase activity
BI313_12940	COG1252	NADH dehydrogenase
BI313_12945	COG2860	membrane
BI313_12950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI313_12960	COG2201	protein-glutamate methylesterase activity
BI313_12965	COG2177	Part of the ABC transporter FtsEX involved in
BI313_12970	COG2884	Cell division ATP-binding protein ftsE
BI313_12980	COG3118	belongs to the thioredoxin family
BI313_12985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI313_12995	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BI313_13000	COG0583	DNA-binding transcription factor activity
BI313_13020	COG1652	LysM domain
BI313_13025	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI313_13025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI313_13030	COG1473	amidohydrolase
BI313_13035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_13040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_13060	COG5383	Protein conserved in bacteria
BI313_13100	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BI313_13105	COG3023	N-Acetylmuramoyl-L-alanine amidase
BI313_13115	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_13125	COG0531	amino acid
BI313_13140	COG4682	membrane
BI313_13145	COG2133	pyrroloquinoline quinone binding
BI313_13155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BI313_13160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI313_13165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BI313_13170	COG1610	YqeY-like protein
BI313_13175	COG1295	ribonuclease BN
BI313_13180	COG0358	DNA primase activity
BI313_13235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BI313_13245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI313_13290	COG0739	heme binding
BI313_13305	COG2211	Major facilitator Superfamily
BI313_13315	COG0708	Exodeoxyribonuclease III
BI313_13330	COG1192	Involved in chromosome partitioning
BI313_13335	COG1475	DNA binding
BI313_13355	COG0463	Glycosyl transferase, family 2
BI313_13375	COG0756	dUTP diphosphatase activity
BI313_13380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI313_13390	COG0018	arginyl-trna synthetase
BI313_13405	COG4221	oxidoreductase activity
BI313_13410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BI313_13410	COG2755	lipolytic protein G-D-S-L family
BI313_13430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI313_13435	COG1166	arginine decarboxylase activity
BI313_13440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BI313_13460	COG3525	Glycosyl hydrolase, family 20, catalytic domain
BI313_13460	COG3291	Pkd domain containing protein
BI313_13475	COG2960	long-chain fatty acid transporting porin activity
BI313_13480	COG0606	chelatase, subunit chli
BI313_13495	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BI313_13525	COG1690	Belongs to the RtcB family
BI313_13565	COG1090	epimerase
BI313_13570	COG0745	RESPONSE REGULATOR receiver
BI313_13575	COG0642	Histidine kinase
BI313_13595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI313_13615	COG0628	permease
BI313_13625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI313_13640	COG0753	catalase activity
BI313_13655	COG2197	response regulator
BI313_13665	COG4585	Histidine kinase
BI313_13670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_13675	COG1136	(ABC) transporter
BI313_13700	COG0697	spore germination
BI313_13720	COG0180	Tryptophanyl-tRNA synthetase
BI313_13725	COG3237	CsbD-like
BI313_13765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI313_13780	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BI313_13785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BI313_13785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BI313_13795	COG3228	Belongs to the MtfA family
BI313_13810	COG2205	protein histidine kinase activity
BI313_13815	COG0745	RESPONSE REGULATOR receiver
BI313_13825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI313_13850	COG1199	ATP-dependent helicase activity
BI313_13875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI313_13915	COG0625	glutathione transferase activity
BI313_13950	COG4555	ABC transporter
BI313_13960	COG1476	TRANSCRIPTIONal
BI313_13985	COG0543	2 iron, 2 sulfur cluster binding
BI313_13985	COG0633	Ferredoxin
BI313_13990	COG1131	(ABC) transporter
BI313_13995	COG0842	Transport permease protein
BI313_14000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BI313_14010	COG1607	acyl-coa hydrolase
BI313_14015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_14030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI313_14035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI313_14060	COG1042	CoA-binding domain protein
BI313_14060	COG0045	succinate-CoA ligase (ADP-forming) activity
BI313_14060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI313_14065	COG2239	Acts as a magnesium transporter
BI313_14070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BI313_14070	COG0475	glutathione-regulated potassium exporter activity
BI313_14075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI313_14080	COG3387	PFAM Glycoside hydrolase 15-related
BI313_14095	COG3100	YcgL domain-containing protein
BI313_14100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BI313_14135	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_14160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI313_14175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI313_14225	COG0408	coproporphyrinogen oxidase activity
BI313_14260	COG0515	serine threonine protein kinase
BI313_14265	COG0631	protein serine/threonine phosphatase activity
BI313_14290	COG0667	Aldo Keto reductase
BI313_14295	COG0583	DNA-binding transcription factor activity
BI313_14315	COG3501	Rhs element vgr protein
BI313_14440	COG0210	DNA helicase
BI313_14455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_14460	COG0583	DNA-binding transcription factor activity
BI313_14465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BI313_14475	COG2159	amidohydrolase
BI313_14480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BI313_14485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BI313_14525	COG2091	lysine biosynthetic process via aminoadipic acid
BI313_14560	COG3162	membrane
BI313_14600	COG3507	Belongs to the glycosyl hydrolase 43 family
BI313_14615	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_14620	COG0179	Fumarylacetoacetate (FAA) hydrolase
BI313_14625	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_14630	COG3254	rhamnose metabolic process
BI313_14635	COG0738	Major facilitator superfamily
BI313_14640	COG1414	Transcriptional regulator
BI313_14650	COG2205	protein histidine kinase activity
BI313_14650	COG0784	Response regulator, receiver
BI313_14665	COG3459	Glycosyltransferase 36 associated
BI313_14670	COG2211	Major facilitator Superfamily
BI313_14675	COG3265	gluconokinase activity
BI313_14680	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BI313_14705	COG0729	surface antigen
BI313_14710	COG4771	TonB-dependent receptor
BI313_14715	COG0457	Tetratricopeptide repeat
BI313_14730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI313_14740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI313_14740	COG0519	Catalyzes the synthesis of GMP from XMP
BI313_14755	COG0805	protein transport
BI313_14765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BI313_14775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI313_14795	COG2974	May be involved in recombination
BI313_14800	COG0037	tRNA processing
BI313_14810	COG2115	Belongs to the xylose isomerase family
BI313_14820	COG3661	Belongs to the glycosyl hydrolase 67 family
BI313_14830	COG4948	Mandelate Racemase Muconate Lactonizing
BI313_14840	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_14845	COG0246	Mannitol dehydrogenase
BI313_14875	COG3386	PFAM SMP-30 Gluconolaconase
BI313_14885	COG3250	beta-galactosidase activity
BI313_14890	COG1904	glucuronate isomerase
BI313_14895	COG3693	PFAM glycoside hydrolase, family 10
BI313_14910	COG2211	Major facilitator Superfamily
BI313_14955	COG2937	Belongs to the GPAT DAPAT family
BI313_14990	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BI313_14995	COG3132	Protein of unknown function, DUF480
BI313_15010	COG0210	DNA helicase
BI313_15015	COG1435	thymidine kinase activity
BI313_15025	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BI313_15035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BI313_15065	COG3135	benzoate transporter
BI313_15085	COG0676	glucose-6-phosphate 1-epimerase activity
BI313_15095	COG3012	SEC-C Motif Domain Protein
BI313_15100	COG0730	response to heat
BI313_15120	COG0302	gtp cyclohydrolase
BI313_15135	COG1566	PFAM secretion protein HlyD family protein
BI313_15145	COG1289	transmembrane transporter activity
BI313_15150	COG0477	Major facilitator Superfamily
BI313_15160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_15220	COG0564	pseudouridine synthase activity
BI313_15225	COG2963	transposase activity
BI313_15230	COG2801	Transposase and inactivated derivatives
BI313_15260	COG3549	Plasmid maintenance system killer
BI313_15265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BI313_15270	COG1074	ATP-dependent DNA helicase activity
BI313_15275	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BI313_15315	COG1127	ABC transporter
BI313_15320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BI313_15325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BI313_15340	COG2853	Lipoprotein
BI313_15350	COG0386	Belongs to the glutathione peroxidase family
BI313_15360	COG1322	Protein conserved in bacteria
BI313_15365	COG0604	alcohol dehydrogenase
BI313_15370	COG0583	DNA-binding transcription factor activity
BI313_15380	COG0625	glutathione transferase activity
BI313_15390	COG0531	amino acid
BI313_15395	COG3537	Alpha-1,2-mannosidase
BI313_15410	COG3706	GGDEF domain
BI313_15415	COG1929	Belongs to the glycerate kinase type-1 family
BI313_15435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI313_15445	COG0861	Integral membrane protein TerC family
BI313_15460	COG0584	glycerophosphoryl diester phosphodiesterase
BI313_15475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI313_15485	COG0726	polysaccharide deacetylase
BI313_15495	COG0706	membrane insertase activity
BI313_15505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BI313_15515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI313_15530	COG0187	DNA topoisomerase II activity
BI313_15540	COG0501	Belongs to the peptidase M48B family
BI313_15585	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BI313_15595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_15625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI313_15630	COG0793	Belongs to the peptidase S41A family
BI313_15640	COG4942	peptidase
BI313_15650	COG2234	aminopeptidase activity
BI313_15660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_15665	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_15670	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_15675	COG1064	alcohol dehydrogenase
BI313_15685	COG0493	'glutamate synthase
BI313_15690	COG0070	glutamate synthase
BI313_15690	COG0069	glutamate synthase activity
BI313_15690	COG0067	glutamate synthase
BI313_15725	COG0583	DNA-binding transcription factor activity
BI313_15800	COG1111	helicase
BI313_15800	COG1205	dead DEAH box helicase
BI313_15805	COG1272	protein, Hemolysin III
BI313_15815	COG0625	glutathione transferase activity
BI313_15825	COG3590	peptidase
BI313_15830	COG0583	DNA-binding transcription factor activity
BI313_15835	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_15855	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI313_15865	COG1733	regulation of RNA biosynthetic process
BI313_15900	COG3237	CsbD-like
BI313_15945	COG1309	transcriptional regulator
BI313_15965	COG0628	permease
BI313_15980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_15985	COG0477	Major facilitator Superfamily
BI313_16030	COG0714	Associated with various cellular activities
BI313_16065	COG0596	Alpha beta hydrolase
BI313_16080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BI313_16090	COG4772	TonB-dependent receptor
BI313_16105	COG1012	belongs to the aldehyde dehydrogenase family
BI313_16155	COG1755	Isoprenylcysteine carboxyl methyltransferase
BI313_16160	COG4585	Histidine kinase
BI313_16165	COG2197	response regulator
BI313_16175	COG3710	Transcriptional regulator
BI313_16180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BI313_16190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_16315	COG0366	Alpha amylase catalytic
BI313_16320	COG0366	Alpha amylase catalytic
BI313_16360	COG2755	lipolytic protein G-D-S-L family
BI313_16370	COG2755	lipolytic protein G-D-S-L family
BI313_16370	COG0657	acetylesterase activity
BI313_16380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BI313_16395	COG3507	Belongs to the glycosyl hydrolase 43 family
BI313_16400	COG1609	Transcriptional regulator
BI313_16410	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BI313_16415	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_16430	COG2755	lipolytic protein G-D-S-L family
BI313_16440	COG3186	Phenylalanine-4-hydroxylase
BI313_16445	COG1522	sequence-specific DNA binding
BI313_16460	COG1752	Esterase of the alpha-beta hydrolase superfamily
BI313_16470	COG1119	ATPase activity
BI313_16485	COG1125	glycine betaine transport
BI313_16485	COG0517	IMP dehydrogenase activity
BI313_16500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BI313_16505	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BI313_16530	COG0489	protein tyrosine kinase activity
BI313_16535	COG2062	phosphohistidine phosphatase, SixA
BI313_16540	COG2353	YceI-like domain
BI313_16545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI313_16575	COG1881	PFAM PEBP family protein
BI313_16595	COG0174	glutamine synthetase
BI313_16600	COG0347	Belongs to the P(II) protein family
BI313_16605	COG0004	ammonium transporteR
BI313_16610	COG3852	Histidine kinase
BI313_16615	COG2204	response regulator
BI313_16620	COG2032	superoxide dismutase activity
BI313_16625	COG2032	superoxide dismutase activity
BI313_16645	COG0183	Belongs to the thiolase family
BI313_16685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI313_16690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BI313_16695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI313_16705	COG0028	Belongs to the TPP enzyme family
BI313_16710	COG2205	protein histidine kinase activity
BI313_16715	COG2204	response regulator
BI313_16735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BI313_16750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI313_16755	COG3177	Filamentation induced by cAMP protein fic
BI313_16760	COG0596	Alpha beta hydrolase
BI313_16770	COG0318	PFAM AMP-dependent synthetase and ligase
BI313_16775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI313_16790	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI313_16800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI313_16810	COG0564	pseudouridine synthase activity
BI313_16840	COG0339	signal peptide processing
BI313_16845	COG0339	signal peptide processing
BI313_16875	COG0475	glutathione-regulated potassium exporter activity
BI313_16885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BI313_16890	COG2224	Isocitrate lyase
BI313_16925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BI313_16930	COG1960	acyl-CoA dehydrogenase activity
BI313_16990	COG0523	cobalamin synthesis protein
BI313_17005	COG0697	spore germination
BI313_17015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BI313_17020	COG1846	Transcriptional regulator
BI313_17025	COG1764	response to oxidative stress
BI313_17055	COG0656	L-ascorbic acid biosynthetic process
BI313_17060	COG2130	NADP-dependent
BI313_17075	COG1187	pseudouridine synthase activity
BI313_17085	COG1643	Atp-dependent helicase
BI313_17090	COG0840	transmembrane signaling receptor activity
BI313_17095	COG4807	Protein conserved in bacteria
BI313_17100	COG2351	hydroxyisourate hydrolase activity
BI313_17105	COG2072	flavoprotein involved in K transport
BI313_17125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI313_17165	COG1957	nucleoside hydrolase
BI313_17175	COG2252	PERMEase
BI313_17190	COG0583	DNA-binding transcription factor activity
BI313_17195	COG0084	hydrolase, TatD family'
BI313_17210	COG0583	DNA-binding transcription factor activity
BI313_17215	COG2814	Major facilitator Superfamily
BI313_17230	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_17245	COG1902	pentaerythritol trinitrate reductase activity
BI313_17270	COG0300	oxidoreductase activity
BI313_17285	COG0583	DNA-binding transcription factor activity
BI313_17300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI313_17320	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_17325	COG0604	alcohol dehydrogenase
BI313_17355	COG1733	regulation of RNA biosynthetic process
BI313_17430	COG0129	dihydroxy-acid dehydratase activity
BI313_17440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BI313_17495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI313_17500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI313_17530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BI313_17535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BI313_17545	COG3485	protocatechuate 3,4-dioxygenase
BI313_17550	COG3485	protocatechuate 3,4-dioxygenase
BI313_17560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BI313_17565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI313_17575	COG1414	Transcriptional regulator
BI313_17595	COG0445	tRNA wobble uridine modification
BI313_17605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI313_17630	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_17650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI313_17655	COG1040	competence protein
BI313_17680	COG0840	transmembrane signaling receptor activity
BI313_17695	COG1511	domain protein
BI313_17695	COG3264	Mechanosensitive ion channel
BI313_17700	COG1368	sulfuric ester hydrolase activity
BI313_17710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BI313_17715	COG2354	Protein conserved in bacteria
BI313_17720	COG3706	GGDEF domain
BI313_17720	COG0745	RESPONSE REGULATOR receiver
BI313_17725	COG0297	glycogen (starch) synthase activity
BI313_17735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BI313_17760	COG0702	epimerase
BI313_17765	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_17800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI313_17810	COG4221	oxidoreductase activity
BI313_17825	COG0513	Belongs to the DEAD box helicase family
BI313_17840	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI313_17855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI313_17870	COG3104	oligopeptide transport
BI313_17890	COG2852	Protein conserved in bacteria
BI313_17895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BI313_17910	COG1320	monovalent cation:proton antiporter activity
BI313_17915	COG2212	antiporter activity
BI313_17925	COG0651	ATP synthesis coupled electron transport
BI313_17930	COG1006	Multisubunit Na H antiporter MnhC subunit
BI313_17935	COG2111	Na H antiporter
BI313_17935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI313_17980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BI313_18000	COG0456	acetyltransferase
BI313_18005	COG1597	lipid kinase activity
BI313_18025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI313_18070	COG0134	indole-3-glycerol-phosphate synthase activity
BI313_18080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI313_18095	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BI313_18100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BI313_18140	COG0745	RESPONSE REGULATOR receiver
BI313_18160	COG0316	Belongs to the HesB IscA family
BI313_18165	COG2816	NAD+ diphosphatase activity
BI313_18170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BI313_18195	COG2814	Major facilitator Superfamily
BI313_18200	COG1289	transmembrane transporter activity
BI313_18205	COG0151	Belongs to the GarS family
BI313_18220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BI313_18225	COG2267	carboxylic ester hydrolase activity
BI313_18230	COG0671	phosphoesterase, PA-phosphatase related
BI313_18230	COG2453	phosphatase
BI313_18255	COG4589	Belongs to the CDS family
BI313_18265	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BI313_18285	COG2264	protein methyltransferase activity
BI313_18300	COG0439	Biotin carboxylase
BI313_18310	COG0511	ligase activity, forming carbon-carbon bonds
BI313_18315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BI313_18325	COG1324	tolerance protein
BI313_18330	COG2356	endonuclease I
BI313_18335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BI313_18360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BI313_18380	COG3386	PFAM SMP-30 Gluconolaconase
BI313_18390	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BI313_18435	COG0778	Nitroreductase
BI313_18440	COG2353	YceI-like domain
BI313_18460	COG3052	prosthetic group binding
BI313_18480	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BI313_18495	COG1802	Transcriptional regulator
BI313_18625	COG0435	Glutathione S-transferase
BI313_18670	COG2409	Drug exporters of the RND superfamily
BI313_18690	COG3706	GGDEF domain
BI313_18695	COG1959	2 iron, 2 sulfur cluster binding
BI313_18700	COG3634	alkyl hydroperoxide reductase activity
BI313_18725	COG0697	spore germination
BI313_18745	COG1113	amino acid transport
BI313_18750	COG0598	Magnesium transport protein CorA
BI313_18805	COG0840	transmembrane signaling receptor activity
BI313_18810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BI313_18810	COG5297	Belongs to the glycosyl hydrolase family 6
BI313_18815	COG0659	secondary active sulfate transmembrane transporter activity
BI313_18820	COG3706	GGDEF domain
BI313_18850	COG2943	transferase activity, transferring hexosyl groups
BI313_18860	COG3275	phosphorelay sensor kinase activity
BI313_18870	COG0181	hydroxymethylbilane synthase activity
BI313_18895	COG1505	serine-type exopeptidase activity
BI313_18920	COG2832	Protein of unknown function (DUF454)
BI313_18930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BI313_18940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BI313_18950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI313_18955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI313_18970	COG2153	protein acetylation
BI313_18985	COG2226	methyltransferase
BI313_18990	COG3300	MHYT domain
BI313_18990	COG5001	Diguanylate cyclase
BI313_18995	COG0308	aminopeptidase N
BI313_19030	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BI313_19040	COG3284	Transcriptional regulator
BI313_19050	COG1077	Cell shape determining protein MreB Mrl
BI313_19055	COG1792	Involved in formation and maintenance of cell shape
BI313_19070	COG0772	Belongs to the SEDS family
BI313_19080	COG2951	lytic endotransglycosylase activity
BI313_19085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BI313_19090	COG1686	Belongs to the peptidase S11 family
BI313_19110	COG0321	lipoyl(octanoyl) transferase activity
BI313_19115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI313_19130	COG0583	DNA-binding transcription factor activity
BI313_19140	COG1056	cytidyltransferase-related domain
BI313_19140	COG1051	belongs to the nudix hydrolase family
BI313_19175	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BI313_19180	COG0673	inositol 2-dehydrogenase activity
BI313_19185	COG2823	Periplasmic or secreted lipoprotein
BI313_19190	COG4251	negative regulation of phosphorylation
BI313_19195	COG0784	Response regulator, receiver
BI313_19200	COG4191	Histidine kinase
BI313_19205	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI313_19210	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_19260	COG1459	type II secretion system
BI313_19265	COG2165	general secretion pathway protein
BI313_19280	COG4795	General secretion pathway protein
BI313_19285	COG3156	type II secretion system protein K
BI313_19315	COG1609	Transcriptional regulator
BI313_19320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI313_19325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI313_19345	COG0617	tRNA 3'-terminal CCA addition
BI313_19360	COG0525	valine-tRNA ligase activity
BI313_19375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI313_19385	COG0795	lipopolysaccharide-transporting ATPase activity
BI313_19400	COG4974	Belongs to the 'phage' integrase family
BI313_19405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BI313_19410	COG0047	phosphoribosylformylglycinamidine synthase activity
BI313_19410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI313_19420	COG5295	Hep Hag repeat protein
BI313_19425	COG1404	Belongs to the peptidase S8 family
BI313_19430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI313_19435	COG1459	type II secretion system
BI313_19440	COG2165	general secretion pathway protein
BI313_19445	COG4970	Tfp pilus assembly protein FimT
BI313_19450	COG2165	general secretion pathway protein
BI313_19455	COG4795	General secretion pathway protein
BI313_19460	COG3156	type II secretion system protein K
BI313_19465	COG3166	PFAM Fimbrial assembly family protein
BI313_19480	COG1450	Type ii and iii secretion system protein
BI313_19500	COG2188	Transcriptional regulator
BI313_19545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI313_19560	COG1215	transferase activity, transferring glycosyl groups
BI313_19565	COG1215	transferase activity, transferring glycosyl groups
BI313_19570	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BI313_19575	COG0457	Tetratricopeptide repeat
BI313_19595	COG0242	peptide deformylase activity
BI313_19600	COG0488	(ABC) transporter
BI313_19610	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI313_19625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI313_19625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI313_19685	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BI313_19690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BI313_19700	COG2205	protein histidine kinase activity
BI313_19705	COG0745	RESPONSE REGULATOR receiver
BI313_19710	COG4946	Tricorn protease homolog
BI313_19710	COG1506	peptidase
BI313_19710	COG0823	Involved in the tonB-independent uptake of proteins
BI313_19715	COG0277	FAD linked oxidase domain protein
BI313_19720	COG1988	membrane-bound metal-dependent
BI313_19770	COG3116	cell division
BI313_19780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BI313_19785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI313_19790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI313_19805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI313_19810	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI313_19815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BI313_19840	COG0739	heme binding
BI313_19860	COG0494	nUDIX hydrolase
BI313_19875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI313_19885	COG3321	synthase
BI313_19885	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_19885	COG0604	alcohol dehydrogenase
BI313_19915	COG0366	Alpha amylase catalytic
BI313_19945	COG2226	methyltransferase
BI313_19960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BI313_19980	COG2885	chlorophyll binding
BI313_20000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI313_20010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI313_20020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI313_20025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI313_20030	COG0667	Aldo Keto reductase
BI313_20040	COG4771	TonB-dependent receptor
BI313_20060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BI313_20065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BI313_20085	COG4181	ATPase activity
BI313_20100	COG0642	Histidine kinase
BI313_20110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI313_20120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BI313_20130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI313_20150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI313_20155	COG2967	ApaG domain
BI313_20160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI313_20165	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BI313_20175	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BI313_20180	COG0123	including yeast histone deacetylase and acetoin utilization protein
BI313_20185	COG2096	Adenosyltransferase
BI313_20195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_20200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_20230	COG3384	dioxygenase
BI313_20235	COG0583	DNA-binding transcription factor activity
BI313_20240	COG0318	PFAM AMP-dependent synthetase and ligase
BI313_20250	COG1024	Enoyl-CoA hydratase
BI313_20300	COG0697	spore germination
BI313_20305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BI313_20320	COG3706	GGDEF domain
BI313_20320	COG0745	RESPONSE REGULATOR receiver
BI313_20325	COG0784	Response regulator, receiver
BI313_20325	COG5002	protein histidine kinase activity
BI313_20325	COG2205	protein histidine kinase activity
BI313_20330	COG2197	response regulator
BI313_20340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI313_20350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI313_20355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI313_20360	COG0583	DNA-binding transcription factor activity
BI313_20365	COG3634	alkyl hydroperoxide reductase activity
BI313_20375	COG2890	protein-(glutamine-N5) methyltransferase activity
BI313_20400	COG0778	Nitroreductase
BI313_20430	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI313_20450	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BI313_20455	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BI313_20475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI313_20485	COG1404	Belongs to the peptidase S8 family
BI313_20490	COG1404	Belongs to the peptidase S8 family
BI313_20495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI313_20515	COG1295	ribonuclease BN
BI313_20520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI313_20525	COG1254	Belongs to the acylphosphatase family
BI313_20540	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI313_20565	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BI313_20570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BI313_20580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI313_20585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI313_20590	COG0193	aminoacyl-tRNA hydrolase activity
BI313_20595	COG0012	GTP binding
BI313_20600	COG0582	viral genome integration into host DNA
BI313_20655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI313_20665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BI313_20670	COG0250	Participates in transcription elongation, termination and antitermination
BI313_20675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI313_20680	COG0081	regulation of translation
BI313_20685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI313_20690	COG0222	ribosome binding
BI313_20700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI313_20715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI313_20720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI313_20725	COG0051	transcription antitermination factor activity, RNA binding
BI313_20745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI313_20765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI313_20770	COG0255	Belongs to the universal ribosomal protein uL29 family
BI313_20775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI313_20780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BI313_20785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI313_20795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BI313_20815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BI313_20820	COG1841	ribosomal large subunit assembly
BI313_20825	COG0200	Binds to the 23S rRNA
BI313_20830	COG0201	protein transport
BI313_20835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BI313_20840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BI313_20845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BI313_20850	COG0202	RNA polymerase activity
BI313_20855	COG0203	ribosomal protein L17
BI313_20860	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BI313_20870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BI313_20880	COG0154	amidase activity
BI313_20895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI313_20900	COG0039	L-malate dehydrogenase activity
BI313_20905	COG0625	glutathione transferase activity
BI313_20920	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI313_20920	COG1902	pentaerythritol trinitrate reductase activity
BI313_20935	COG2885	chlorophyll binding
BI313_20960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BI313_20965	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BI313_20970	COG4208	sulfate ABC transporter
BI313_20975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BI313_20985	COG1063	alcohol dehydrogenase
BI313_21005	COG0406	alpha-ribazole phosphatase activity
BI313_21015	COG0285	dihydrofolate synthase activity
BI313_21035	COG2833	Protein of unknown function (DUF455)
BI313_21040	COG3291	Pkd domain containing protein
BI313_21050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_21055	COG0671	phosphoesterase, PA-phosphatase related
BI313_21060	COG0438	transferase activity, transferring glycosyl groups
BI313_21070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI313_21085	COG4783	chaperone-mediated protein folding
BI313_21100	COG0473	3-isopropylmalate dehydrogenase activity
BI313_21135	COG3852	Histidine kinase
BI313_21145	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI313_21150	COG0740	serine-type endopeptidase activity
BI313_21155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI313_21185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI313_21195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI313_21210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI313_21215	COG0631	protein serine/threonine phosphatase activity
BI313_21230	COG0859	PFAM glycosyl transferase family 9
BI313_21240	COG1234	tRNA 3'-trailer cleavage
BI313_21245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI313_21250	COG0315	cyclic pyranopterin monophosphate synthase activity
BI313_21255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BI313_21260	COG0314	molybdopterin synthase activity
BI313_21280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BI313_21290	COG0537	adenosine 5'-monophosphoramidase activity
BI313_21310	COG0714	Associated with various cellular activities
BI313_21330	COG0424	maF-like protein
BI313_21335	COG1399	metal-binding, possibly nucleic acid-binding protein
BI313_21340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI313_21345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI313_21355	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_21360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI313_21370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI313_21375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BI313_21400	COG3829	transcription factor binding
BI313_21445	COG2373	Large extracellular alpha-helical protein
BI313_21470	COG4953	penicillin-binding protein 1C
BI313_21480	COG0678	peroxiredoxin activity
BI313_21500	COG0330	HflC and HflK could
BI313_21505	COG0330	HflC and HflK could
BI313_21510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BI313_21585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BI313_21615	COG1309	transcriptional regulator
BI313_21620	COG0328	RNA-DNA hybrid ribonuclease activity
BI313_21620	COG0406	alpha-ribazole phosphatase activity
BI313_21625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI313_21635	COG3387	PFAM Glycoside hydrolase 15-related
BI313_21640	COG1028	Short-chain dehydrogenase reductase Sdr
BI313_21650	COG3537	Alpha-1,2-mannosidase
BI313_21710	COG1064	alcohol dehydrogenase
BI313_21720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BI313_21725	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BI313_21730	COG2080	2 iron, 2 sulfur cluster binding
BI313_21755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI313_21775	COG0587	DNA-directed DNA polymerase activity
BI313_21790	COG1297	OPT oligopeptide transporter protein
BI313_21800	COG1506	peptidase
BI313_21800	COG0823	Involved in the tonB-independent uptake of proteins
BI313_21815	COG1917	Cupin 2, conserved barrel domain protein
BI313_21815	COG2207	Transcriptional regulator
BI313_21825	COG0753	catalase activity
BI313_21830	COG0656	L-ascorbic acid biosynthetic process
BI313_21835	COG2272	Belongs to the type-B carboxylesterase lipase family
BI313_21840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI313_21840	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI313_21845	COG2814	Major facilitator Superfamily
BI313_21865	COG2194	sulfuric ester hydrolase activity
BI313_21880	COG0745	RESPONSE REGULATOR receiver
BI313_21885	COG5002	protein histidine kinase activity
BI313_21895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BI313_21900	COG2894	cell division
BI313_21915	COG4585	Histidine kinase
BI313_21920	COG2197	response regulator
BI313_21935	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BI313_21965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BI313_21985	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BI313_22005	COG1946	Acyl-CoA thioesterase
BI313_22010	COG1024	Enoyl-CoA hydratase
BI313_22015	COG0824	Thioesterase
BI313_22020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI313_22035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI313_22040	COG0268	Binds directly to 16S ribosomal RNA
BI313_22045	COG0728	peptidoglycan biosynthetic process
BI313_22050	COG0196	riboflavin kinase activity
BI313_22060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI313_22065	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BI313_22080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BI313_22085	COG1845	cytochrome c oxidase, subunit III
BI313_22090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI313_22105	COG3152	Membrane
BI313_22115	COG2207	Transcriptional regulator
BI313_22120	COG0326	Molecular chaperone. Has ATPase activity
BI313_22130	COG1366	Belongs to the anti-sigma-factor antagonist family
BI313_22135	COG1366	Belongs to the anti-sigma-factor antagonist family
BI313_22140	COG2172	sigma factor antagonist activity
BI313_22170	COG4771	TonB-dependent receptor
BI313_22180	COG5507	3-demethylubiquinone-9 3-methyltransferase
BI313_22185	COG0745	RESPONSE REGULATOR receiver
BI313_22185	COG3706	GGDEF domain
BI313_22195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BI313_22200	COG4999	Histidine kinase
BI313_22200	COG2205	protein histidine kinase activity
BI313_22200	COG3437	response regulator, receiver
BI313_22200	COG3850	Histidine kinase
BI313_22205	COG0784	Response regulator, receiver
BI313_22205	COG4191	Histidine kinase
BI313_22240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI313_22245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI313_22255	COG2070	2-Nitropropane dioxygenase
BI313_22275	COG0336	Belongs to the RNA methyltransferase TrmD family
BI313_22285	COG0534	Mate efflux family protein
BI313_22295	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BI313_22305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI313_22310	COG0840	transmembrane signaling receptor activity
BI313_22330	COG3250	beta-galactosidase activity
BI313_22335	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BI313_22355	COG1960	acyl-CoA dehydrogenase activity
BI313_22360	COG1024	Enoyl-CoA hydratase
BI313_22400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI313_22405	COG0481	GTPase activity
BI313_22445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI313_22460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BI313_22465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI313_22465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BI313_22470	COG3046	protein related to deoxyribodipyrimidine photolyase
BI313_22475	COG1472	Belongs to the glycosyl hydrolase 3 family
BI313_22485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BI313_22490	COG1278	Cold shock
BI313_22495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BI313_22505	COG1201	RNA secondary structure unwinding
BI313_22510	COG1793	dna ligase
BI313_22520	COG1793	dna ligase
BI313_22520	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BI313_22535	COG3706	GGDEF domain
BI313_22550	COG0183	Belongs to the thiolase family
BI313_22570	COG1451	nucleotide metabolic process
BI313_22575	COG5487	UPF0391 membrane protein
BI313_22585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BI313_22625	COG1047	Peptidyl-prolyl cis-trans
BI313_22635	COG2824	Alkylphosphonate utilization operon protein PhnA
BI313_22650	COG1902	pentaerythritol trinitrate reductase activity
BI313_22655	COG2814	Major facilitator Superfamily
BI313_22690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BI313_22690	COG0392	lysyltransferase activity
BI313_22700	COG0251	oxidation-reduction process
BI313_22705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI313_22720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BI313_22745	COG1595	DNA-templated transcription, initiation
BI313_22760	COG2878	Part of a membrane complex involved in electron transport
BI313_22770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI313_22770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI313_22790	COG0346	lactoylglutathione lyase activity
BI313_22795	COG0833	amino acid
BI313_22800	COG2040	homocysteine
BI313_22815	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI313_22840	COG1695	Transcriptional regulator
BI313_22870	COG0825	malonyl-CoA metabolic process
BI313_22885	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_22890	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_22900	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BI313_22915	COG0750	zinc metalloprotease
BI313_22920	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BI313_22925	COG0575	Belongs to the CDS family
BI313_22930	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BI313_22940	COG0528	UMP kinase activity
BI313_22945	COG0745	RESPONSE REGULATOR receiver
BI313_22945	COG3706	GGDEF domain
BI313_22950	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BI313_22990	COG0024	Methionine aminopeptidase
BI313_22995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BI313_23010	COG1393	Belongs to the ArsC family
BI313_23015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI313_23020	COG0367	asparagine synthase
BI313_23030	COG4774	siderophore transport
BI313_23075	COG1566	PFAM secretion protein HlyD family protein
BI313_23080	COG2814	Major facilitator Superfamily
BI313_23135	COG0339	signal peptide processing
BI313_23140	COG0386	Belongs to the glutathione peroxidase family
BI313_23210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI313_23215	COG0084	hydrolase, TatD family'
BI313_23230	COG1960	acyl-CoA dehydrogenase activity
BI313_23245	COG0367	asparagine synthase
BI313_23255	COG0305	Participates in initiation and elongation during chromosome replication
BI313_23260	COG0415	Belongs to the DNA photolyase family
BI313_23275	COG0583	DNA-binding transcription factor activity
BI313_23290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BI313_23310	COG3706	GGDEF domain
BI313_23330	COG3316	Transposase and inactivated derivatives
BI313_23335	COG3838	Conjugal transfer protein Trbc
BI313_23340	COG5268	conjugation
BI313_23345	COG3451	type IV secretory pathway VirB4
BI313_23490	COG3316	Transposase and inactivated derivatives
BI313_23495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BI313_23500	COG3316	Transposase and inactivated derivatives
BI313_23505	COG4962	Type ii secretion system protein e
BI313_23640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone