locus-tag	class	description
HGO23_00010	COG0592	DNA-directed DNA polymerase activity
HGO23_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGO23_00020	COG0187	DNA topoisomerase II activity
HGO23_00040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGO23_00065	COG0705	Rhomboid family
HGO23_00080	COG1280	lysine exporter protein (LysE YggA)
HGO23_00085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGO23_00090	COG4638	Rieske (2fe-2S)
HGO23_00095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGO23_00100	COG0473	3-isopropylmalate dehydrogenase activity
HGO23_00105	COG0583	DNA-binding transcription factor activity
HGO23_00140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGO23_00145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGO23_00150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HGO23_00155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGO23_00160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HGO23_00165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HGO23_00170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGO23_00175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGO23_00185	COG0356	it plays a direct role in the translocation of protons across the membrane
HGO23_00190	COG3312	ion transport
HGO23_00195	COG0357	Ribosomal RNA small subunit methyltransferase G
HGO23_00200	COG0445	tRNA wobble uridine modification
HGO23_00205	COG0716	FMN binding
HGO23_00210	COG1522	sequence-specific DNA binding
HGO23_00215	COG2502	aspartate--ammonia ligase
HGO23_00220	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HGO23_00225	COG0714	Associated with various cellular activities
HGO23_00230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGO23_00240	COG0477	Major facilitator Superfamily
HGO23_00285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGO23_00290	COG3162	membrane
HGO23_00295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGO23_00300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGO23_00305	COG2258	MOSC domain
HGO23_00320	COG0180	Tryptophanyl-tRNA synthetase
HGO23_00325	COG0546	phosphoglycolate phosphatase activity
HGO23_00330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGO23_00345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HGO23_00350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGO23_00355	COG4796	Type ii and iii secretion system protein
HGO23_00375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HGO23_00385	COG0494	nUDIX hydrolase
HGO23_00395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HGO23_00400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HGO23_00405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HGO23_00420	COG1278	Cold shock
HGO23_00475	COG2081	HI0933 family
HGO23_00480	COG0306	phosphate transporter
HGO23_00490	COG0589	response to stress
HGO23_00500	COG0742	ribosomal rna small subunit methyltransferase
HGO23_00525	COG0366	Alpha amylase catalytic
HGO23_00530	COG1263	PTS System
HGO23_00530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGO23_00540	COG3964	amidohydrolase
HGO23_00570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_00570	COG3711	transcriptional antiterminator
HGO23_00605	COG3327	negative regulation of DNA-templated transcription, initiation
HGO23_00610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HGO23_00615	COG0183	Belongs to the thiolase family
HGO23_00620	COG2050	protein possibly involved in aromatic compounds catabolism
HGO23_00625	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGO23_00630	COG1024	Enoyl-CoA hydratase
HGO23_00635	COG1024	Enoyl-CoA hydratase
HGO23_00640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGO23_00645	COG2151	metal-sulfur cluster biosynthetic enzyme
HGO23_00650	COG3396	Phenylacetate-CoA oxygenase
HGO23_00655	COG3460	Phenylacetate-CoA oxygenase
HGO23_00660	COG3396	Phenylacetate-CoA oxygenase
HGO23_00665	COG1012	belongs to the aldehyde dehydrogenase family
HGO23_00665	COG2030	dehydratase
HGO23_00680	COG0626	cystathionine gamma-synthase activity
HGO23_00695	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HGO23_00700	COG3457	Alanine racemase
HGO23_00710	COG2188	Transcriptional regulator
HGO23_00715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HGO23_00720	COG1349	DNA-binding transcription factor activity
HGO23_00725	COG0705	Rhomboid family
HGO23_00730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGO23_00735	COG0316	Belongs to the HesB IscA family
HGO23_00735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGO23_00745	COG0596	Alpha beta hydrolase
HGO23_00755	COG5654	RES domain protein
HGO23_00760	COG5642	Protein of unknown function (DUF2384)
HGO23_00775	COG1918	ferrous iron import across plasma membrane
HGO23_00785	COG2183	response to ionizing radiation
HGO23_00790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGO23_00810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGO23_00815	COG0573	inorganic phosphate transmembrane transporter activity
HGO23_00820	COG0581	inorganic phosphate transmembrane transporter activity
HGO23_00825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HGO23_00830	COG0704	Plays a role in the regulation of phosphate uptake
HGO23_00835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGO23_00840	COG0765	amino acid transport
HGO23_00845	COG0765	amino acid transport
HGO23_00855	COG3157	Type VI secretion system effector, Hcp
HGO23_00870	COG0477	Major facilitator Superfamily
HGO23_00880	COG2252	PERMEase
HGO23_00905	COG0612	Peptidase, M16
HGO23_00910	COG2199	diguanylate cyclase activity
HGO23_00910	COG2200	EAL domain
HGO23_00915	COG4608	Belongs to the ABC transporter superfamily
HGO23_00920	COG0444	Belongs to the ABC transporter superfamily
HGO23_00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGO23_00930	COG0601	transmembrane transport
HGO23_00935	COG0747	negative chemotaxis
HGO23_00945	COG0751	glycine-tRNA ligase activity
HGO23_00950	COG0752	glycyl-tRNA synthetase alpha subunit
HGO23_00955	COG2818	Glycosylase
HGO23_00960	COG3977	Valine--pyruvate aminotransferase
HGO23_00965	COG5645	(Lipo)protein
HGO23_00970	COG0823	Involved in the tonB-independent uptake of proteins
HGO23_00975	COG2860	membrane
HGO23_00980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGO23_00985	COG0194	GDP metabolic process
HGO23_00995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGO23_01005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGO23_01010	COG0786	glutamate:sodium symporter activity
HGO23_01015	COG2233	PERMEase
HGO23_01020	COG2982	Protein involved in outer membrane biogenesis
HGO23_01025	COG0456	acetyltransferase
HGO23_01030	COG1490	D-aminoacyl-tRNA deacylase activity
HGO23_01035	COG1011	Hydrolase
HGO23_01155	COG1295	ribonuclease BN
HGO23_01160	COG1942	4-Oxalocrotonate Tautomerase
HGO23_01170	COG3501	Rhs element vgr protein
HGO23_01185	COG3209	COG3209 Rhs family protein
HGO23_01260	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HGO23_01265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGO23_01285	COG1070	Carbohydrate kinase
HGO23_01290	COG2390	Transcriptional regulator
HGO23_01305	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGO23_01310	COG1879	ABC-type sugar transport system periplasmic component
HGO23_01315	COG1830	Aldolase
HGO23_01320	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HGO23_01325	COG1763	Mo-molybdopterin cofactor biosynthetic process
HGO23_01330	COG0746	molybdenum cofactor guanylyltransferase activity
HGO23_01335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGO23_01345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGO23_01345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGO23_01350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGO23_01355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGO23_01365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGO23_01370	COG3954	Phosphoribulokinase
HGO23_01375	COG3089	Belongs to the UPF0270 family
HGO23_01385	COG1263	PTS System
HGO23_01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGO23_01390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HGO23_01405	COG0583	DNA-binding transcription factor activity
HGO23_01410	COG0488	(ABC) transporter
HGO23_01415	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HGO23_01420	COG1047	Peptidyl-prolyl cis-trans
HGO23_01425	COG2900	Belongs to the SlyX family
HGO23_01430	COG0545	Peptidyl-prolyl cis-trans isomerase
HGO23_01435	COG2964	Protein conserved in bacteria
HGO23_01440	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HGO23_01445	COG2923	Belongs to the DsrF TusC family
HGO23_01450	COG2168	tRNA wobble position uridine thiolation
HGO23_01455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGO23_01460	COG0049	tRNA binding
HGO23_01465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGO23_01470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGO23_01480	COG0250	Participates in transcription elongation, termination and antitermination
HGO23_01485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HGO23_01490	COG0081	regulation of translation
HGO23_01495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGO23_01500	COG0222	ribosome binding
HGO23_01505	COG0085	RNA polymerase activity
HGO23_01510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGO23_01515	COG0726	polysaccharide deacetylase
HGO23_01525	COG4580	involved in the transport of maltose and maltodextrins
HGO23_01530	COG3842	ATPase activity
HGO23_01540	COG1175	transmembrane transport
HGO23_01545	COG3833	ABC-type maltose transport systems, permease component
HGO23_01550	COG1640	4-alpha-glucanotransferase
HGO23_01555	COG0058	SHG alpha-glucan phosphorylase activity
HGO23_01560	COG2909	trisaccharide binding
HGO23_01565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGO23_01570	COG1063	alcohol dehydrogenase
HGO23_01575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGO23_01580	COG2223	nitrite transmembrane transporter activity
HGO23_01595	COG2022	thiamine diphosphate biosynthetic process
HGO23_01600	COG2104	thiamine diphosphate biosynthetic process
HGO23_01605	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGO23_01610	COG0352	thiamine-phosphate diphosphorylase activity
HGO23_01615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HGO23_01625	COG2816	NAD+ diphosphatase activity
HGO23_01630	COG0339	signal peptide processing
HGO23_01635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HGO23_01640	COG1515	deoxyribonuclease V activity
HGO23_01660	COG0151	Belongs to the GarS family
HGO23_01665	COG0138	bifunctional purine biosynthesis protein purh
HGO23_01695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HGO23_01700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HGO23_01705	COG4770	biotin carboxylase activity
HGO23_01715	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HGO23_01720	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HGO23_01725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HGO23_01730	COG1053	succinate dehydrogenase
HGO23_01750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HGO23_01755	COG0584	glycerophosphoryl diester phosphodiesterase
HGO23_01760	COG2271	Major facilitator Superfamily
HGO23_01780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HGO23_01785	COG0425	Belongs to the sulfur carrier protein TusA family
HGO23_01795	COG3714	YhhN family
HGO23_01800	COG3776	membrane
HGO23_01805	COG0742	ribosomal rna small subunit methyltransferase
HGO23_01810	COG0552	protein localization to endoplasmic reticulum
HGO23_01810	COG0552	protein localization to endoplasmic reticulum
HGO23_01815	COG2884	Cell division ATP-binding protein ftsE
HGO23_01820	COG2177	Part of the ABC transporter FtsEX involved in
HGO23_01835	COG1929	Belongs to the glycerate kinase type-1 family
HGO23_01840	COG1396	sequence-specific DNA binding
HGO23_01860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HGO23_01865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGO23_01870	COG2264	protein methyltransferase activity
HGO23_01875	COG4145	pantothenate transmembrane transporter activity
HGO23_01880	COG3924	membrane
HGO23_01885	COG0439	Biotin carboxylase
HGO23_01890	COG0511	ligase activity, forming carbon-carbon bonds
HGO23_01895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HGO23_01900	COG0604	alcohol dehydrogenase
HGO23_01905	COG1077	Cell shape determining protein MreB Mrl
HGO23_01910	COG1792	Involved in formation and maintenance of cell shape
HGO23_01915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HGO23_01920	COG0424	maF-like protein
HGO23_01930	COG3164	Protein of unknown function
HGO23_01935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGO23_01940	COG0312	modulator of DNA gyrase
HGO23_01950	COG2732	(Barnase) inhibitor
HGO23_01960	COG3028	Belongs to the UPF0307 family
HGO23_01965	COG0312	modulator of DNA gyrase
HGO23_01970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGO23_01980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_01985	COG1660	Displays ATPase and GTPase activities
HGO23_02000	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HGO23_02005	COG1137	ATPase activity
HGO23_02010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HGO23_02015	COG3117	lipopolysaccharide transmembrane transporter activity
HGO23_02020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HGO23_02025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGO23_02025	COG0517	IMP dehydrogenase activity
HGO23_02030	COG0530	calcium, potassium:sodium antiporter activity
HGO23_02035	COG1127	ABC transporter
HGO23_02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HGO23_02045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HGO23_02050	COG2854	intermembrane phospholipid transfer
HGO23_02060	COG5007	Belongs to the BolA IbaG family
HGO23_02065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGO23_02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGO23_02075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGO23_02080	COG3105	Protein conserved in bacteria
HGO23_02085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HGO23_02090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGO23_02095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGO23_02100	COG0625	glutathione transferase activity
HGO23_02105	COG2969	positive regulation of protein catabolic process
HGO23_02115	COG0493	'glutamate synthase
HGO23_02120	COG0070	glutamate synthase
HGO23_02120	COG0069	glutamate synthase activity
HGO23_02120	COG0067	glutamate synthase
HGO23_02125	COG5002	protein histidine kinase activity
HGO23_02125	COG2198	Histidine kinase
HGO23_02125	COG0784	Response regulator, receiver
HGO23_02130	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HGO23_02135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGO23_02140	COG2823	Periplasmic or secreted lipoprotein
HGO23_02145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HGO23_02150	COG0792	nuclease activity
HGO23_02160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGO23_02170	COG1741	Belongs to the pirin family
HGO23_02175	COG0583	DNA-binding transcription factor activity
HGO23_02180	COG2259	Doxx family
HGO23_02190	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HGO23_02195	COG4575	ribosome binding
HGO23_02200	COG0586	Pfam SNARE associated Golgi protein
HGO23_02205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HGO23_02210	COG1902	pentaerythritol trinitrate reductase activity
HGO23_02210	COG0446	pyridine nucleotide-disulphide oxidoreductase
HGO23_02220	COG2990	Protein conserved in bacteria
HGO23_02240	COG0439	Biotin carboxylase
HGO23_02300	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HGO23_02400	COG4626	Terminase
HGO23_02400	COG1802	Transcriptional regulator
HGO23_02410	COG3423	Transcriptional regulator
HGO23_02430	COG0358	DNA primase activity
HGO23_02435	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HGO23_02440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGO23_02445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HGO23_02450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HGO23_02460	COG0459	protein refolding
HGO23_02465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HGO23_02480	COG1027	Aspartate ammonia-lyase
HGO23_02485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HGO23_02490	COG4232	protein-disulfide reductase activity
HGO23_02495	COG1309	transcriptional regulator
HGO23_02505	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGO23_02570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HGO23_02600	COG3436	PFAM IS66 Orf2 family protein
HGO23_02640	COG3210	domain, Protein
HGO23_02640	COG3210	domain, Protein
HGO23_02650	COG2831	hemolysin activation secretion protein
HGO23_02810	COG3423	Transcriptional regulator
HGO23_02840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGO23_02905	COG0156	8-amino-7-oxononanoate synthase activity
HGO23_02935	COG3423	Transcriptional regulator
HGO23_02940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGO23_02970	COG0017	Asparaginyl-tRNA synthetase
HGO23_02975	COG2226	methyltransferase
HGO23_02980	COG1619	proteins homologs of microcin C7 resistance protein MccF
HGO23_03000	COG0495	leucyl-tRNA aminoacylation
HGO23_03005	COG0442	prolyl-tRNA aminoacylation
HGO23_03060	COG3385	transposase activity
HGO23_03095	COG1509	lysine 2,3-aminomutase activity
HGO23_03100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGO23_03105	COG2076	Multidrug Resistance protein
HGO23_03110	COG3423	Transcriptional regulator
HGO23_03125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGO23_03135	COG1012	belongs to the aldehyde dehydrogenase family
HGO23_03140	COG1785	Belongs to the alkaline phosphatase family
HGO23_03160	COG2813	Specifically methylates the guanine in position
HGO23_03175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HGO23_03185	COG4667	esterase of the alpha-beta hydrolase superfamily
HGO23_03190	COG0084	hydrolase, TatD family'
HGO23_03195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGO23_03200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HGO23_03205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HGO23_03210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HGO23_03215	COG0813	purine-nucleoside phosphorylase activity
HGO23_03220	COG3539	Fimbrial protein
HGO23_03225	COG3188	usher protein
HGO23_03230	COG3121	Chaperone
HGO23_03245	COG1396	sequence-specific DNA binding
HGO23_03255	COG0156	8-amino-7-oxononanoate synthase activity
HGO23_03270	COG1193	negative regulation of DNA recombination
HGO23_03275	COG0456	acetyltransferase
HGO23_03280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGO23_03290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HGO23_03340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HGO23_03345	COG1047	Peptidyl-prolyl cis-trans
HGO23_03350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGO23_03355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGO23_03360	COG0196	riboflavin kinase activity
HGO23_03365	COG0268	Binds directly to 16S ribosomal RNA
HGO23_03370	COG0583	DNA-binding transcription factor activity
HGO23_03375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HGO23_03410	COG0484	heat shock protein binding
HGO23_03415	COG0443	Heat shock 70 kDa protein
HGO23_03420	COG1584	GPR1 FUN34 yaaH family protein
HGO23_03455	COG2723	6-phospho-beta-galactosidase activity
HGO23_03460	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGO23_03465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGO23_03470	COG3022	response to hydroperoxide
HGO23_03480	COG0083	homoserine kinase activity
HGO23_03490	COG0745	RESPONSE REGULATOR receiver
HGO23_03495	COG3045	CreA protein
HGO23_03500	COG2207	Transcriptional regulator
HGO23_03500	COG3708	Transcriptional regulator
HGO23_03505	COG0406	alpha-ribazole phosphatase activity
HGO23_03510	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HGO23_03515	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HGO23_03520	COG0741	lytic transglycosylase activity
HGO23_03525	COG0488	(ABC) transporter
HGO23_03530	COG1136	(ABC) transporter
HGO23_03540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGO23_03545	COG0560	Phosphoserine phosphatase
HGO23_03550	COG3726	membrane protein affecting hemolysin expression
HGO23_03560	COG0656	L-ascorbic acid biosynthetic process
HGO23_03570	COG0626	cystathionine gamma-synthase activity
HGO23_03580	COG0848	biopolymer transport protein
HGO23_03590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_03595	COG2723	6-phospho-beta-galactosidase activity
HGO23_03605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HGO23_03625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HGO23_03630	COG2974	May be involved in recombination
HGO23_03635	COG1940	carbohydrate kinase activity
HGO23_03640	COG0737	Belongs to the 5'-nucleotidase family
HGO23_03650	COG4166	transmembrane transport
HGO23_03660	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_03700	COG1358	cellular component organization or biogenesis
HGO23_03715	COG2862	Uncharacterized protein family, UPF0114
HGO23_03725	COG0419	ATPase involved in DNA repair
HGO23_03730	COG0420	3'-5' exonuclease activity
HGO23_03735	COG0745	RESPONSE REGULATOR receiver
HGO23_03740	COG5002	protein histidine kinase activity
HGO23_03760	COG0450	alkyl hydroperoxide reductase
HGO23_03765	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HGO23_03770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGO23_03775	COG0343	queuine tRNA-ribosyltransferase activity
HGO23_03780	COG1862	Preprotein translocase
HGO23_03785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGO23_03790	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGO23_03795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGO23_03800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGO23_03800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGO23_03805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGO23_03810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGO23_03815	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HGO23_03820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HGO23_03825	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HGO23_03850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HGO23_03860	COG0183	Belongs to the thiolase family
HGO23_03865	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGO23_03865	COG1024	Enoyl-CoA hydratase
HGO23_03870	COG0006	proline dipeptidase activity
HGO23_03875	COG1739	Uncharacterized protein family UPF0029
HGO23_03920	COG0504	CTP synthase activity
HGO23_03925	COG0148	phosphopyruvate hydratase activity
HGO23_03930	COG0471	metal ion transport
HGO23_03945	COG2501	S4 domain
HGO23_03950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGO23_03960	COG0582	viral genome integration into host DNA
HGO23_04010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGO23_04130	COG3772	lysozyme
HGO23_04165	COG3728	DNA packaging
HGO23_04165	COG5484	DNA packaging
HGO23_04305	COG3620	sequence-specific DNA binding
HGO23_04310	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HGO23_04315	COG0582	viral genome integration into host DNA
HGO23_04340	COG1484	DNA-dependent DNA replication
HGO23_04345	COG0305	Participates in initiation and elongation during chromosome replication
HGO23_04395	COG1802	Transcriptional regulator
HGO23_04395	COG4626	Terminase
HGO23_04400	COG4695	Portal protein
HGO23_04530	COG3209	COG3209 Rhs family protein
HGO23_04545	COG3501	Rhs element vgr protein
HGO23_04560	COG0582	viral genome integration into host DNA
HGO23_04630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGO23_04640	COG0582	viral genome integration into host DNA
HGO23_04710	COG1802	Transcriptional regulator
HGO23_04710	COG4626	Terminase
HGO23_04715	COG3423	Transcriptional regulator
HGO23_04740	COG1448	Aminotransferase
HGO23_04765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGO23_04825	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HGO23_04830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGO23_04835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGO23_04845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGO23_04855	COG1489	DNA binding
HGO23_04860	COG1643	Atp-dependent helicase
HGO23_04865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGO23_04870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGO23_04875	COG0316	Belongs to the HesB IscA family
HGO23_04880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGO23_04895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGO23_04910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGO23_04915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGO23_04920	COG3956	TIGRFAM MazG family protein
HGO23_04925	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HGO23_04940	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HGO23_04945	COG2224	Isocitrate lyase
HGO23_04950	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HGO23_04960	COG0800	Aldolase
HGO23_04965	COG1414	Transcriptional regulator
HGO23_04975	COG2801	Transposase and inactivated derivatives
HGO23_05000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGO23_05005	COG0494	nUDIX hydrolase
HGO23_05015	COG0582	viral genome integration into host DNA
HGO23_05045	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HGO23_05045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGO23_05105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HGO23_05135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HGO23_05175	COG3561	AntA/AntB antirepressor
HGO23_05235	COG3423	Transcriptional regulator
HGO23_05245	COG0288	reversible hydration of carbon dioxide
HGO23_05250	COG1131	(ABC) transporter
HGO23_05255	COG0842	Transport permease protein
HGO23_05265	COG1388	LysM domain
HGO23_05265	COG0741	lytic transglycosylase activity
HGO23_05270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGO23_05275	COG2226	methyltransferase
HGO23_05300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGO23_05305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGO23_05310	COG0126	phosphoglycerate kinase activity
HGO23_05320	COG3104	oligopeptide transport
HGO23_05325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGO23_05330	COG2368	4-hydroxyphenylacetate
HGO23_05350	COG3971	2-oxopent-4-enoate hydratase activity
HGO23_05365	COG3384	dioxygenase
HGO23_05370	COG1012	belongs to the aldehyde dehydrogenase family
HGO23_05380	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGO23_05385	COG1846	Transcriptional regulator
HGO23_05390	COG2814	Major facilitator Superfamily
HGO23_05405	COG3962	Belongs to the TPP enzyme family
HGO23_05410	COG0673	inositol 2-dehydrogenase activity
HGO23_05415	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGO23_05420	COG0673	inositol 2-dehydrogenase activity
HGO23_05425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGO23_05435	COG3718	enzyme involved in inositol metabolism
HGO23_05460	COG1309	transcriptional regulator
HGO23_05475	COG0443	Heat shock 70 kDa protein
HGO23_05480	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HGO23_05500	COG5564	TIM-barrel signal transduction protein
HGO23_05505	COG5441	Belongs to the UPF0261 family
HGO23_05525	COG0540	Belongs to the ATCase OTCase family
HGO23_05555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGO23_05570	COG0488	(ABC) transporter
HGO23_05595	COG2814	Major facilitator Superfamily
HGO23_05600	COG0735	belongs to the Fur family
HGO23_05610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HGO23_05615	COG2937	Belongs to the GPAT DAPAT family
HGO23_05620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HGO23_05625	COG3161	chorismate lyase activity
HGO23_05630	COG0166	Belongs to the GPI family
HGO23_05635	COG0527	aspartate kinase activity
HGO23_05655	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HGO23_05665	COG3344	reverse transcriptase
HGO23_05670	COG2814	Major facilitator Superfamily
HGO23_05675	COG0583	DNA-binding transcription factor activity
HGO23_05685	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_05715	COG3344	reverse transcriptase
HGO23_05765	COG3423	Transcriptional regulator
HGO23_05775	COG0740	serine-type endopeptidase activity
HGO23_05785	COG0477	Major facilitator Superfamily
HGO23_05825	COG3423	Transcriptional regulator
HGO23_05920	COG1724	mRNA binding
HGO23_05925	COG1598	PFAM Uncharacterised protein family UPF0150
HGO23_05940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGO23_05945	COG2867	negative regulation of translational initiation
HGO23_05950	COG2914	Belongs to the UPF0125 (RnfH) family
HGO23_05955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGO23_05960	COG0497	DNA recombination
HGO23_05965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGO23_05970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGO23_05975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HGO23_05985	COG0513	Belongs to the DEAD box helicase family
HGO23_06350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HGO23_06355	COG1595	DNA-templated transcription, initiation
HGO23_06365	COG3026	antisigma factor binding
HGO23_06370	COG3086	response to oxidative stress
HGO23_06375	COG0481	GTPase activity
HGO23_06380	COG0681	Belongs to the peptidase S26 family
HGO23_06385	COG0571	ribonuclease III activity
HGO23_06395	COG1381	Involved in DNA repair and RecF pathway recombination
HGO23_06400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HGO23_06405	COG0736	holo-[acyl-carrier-protein] synthase activity
HGO23_06410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HGO23_06695	COG4386	tail sheath protein
HGO23_06720	COG3077	Addiction module antitoxin, RelB DinJ family
HGO23_06745	COG4381	Mu-like prophage protein gp46
HGO23_06760	COG5301	cellulose 1,4-beta-cellobiosidase activity
HGO23_06795	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HGO23_06810	COG2161	toxin-antitoxin pair type II binding
HGO23_06815	COG4115	mRNA cleavage
HGO23_06845	COG1418	mRNA catabolic process
HGO23_06855	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HGO23_06860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGO23_06860	COG0047	phosphoribosylformylglycinamidine synthase activity
HGO23_06865	COG2205	protein histidine kinase activity
HGO23_06870	COG3170	Tfp pilus assembly protein FimV
HGO23_06875	COG2204	response regulator
HGO23_06880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGO23_06880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HGO23_06885	COG0347	Belongs to the P(II) protein family
HGO23_06890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGO23_06890	COG1017	nitric oxide dioxygenase activity
HGO23_06895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGO23_06900	COG2814	Major facilitator Superfamily
HGO23_06910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HGO23_06915	COG1959	2 iron, 2 sulfur cluster binding
HGO23_06920	COG1104	cysteine desulfurase activity
HGO23_06925	COG0822	iron-sulfur transferase activity
HGO23_06930	COG0316	Belongs to the HesB IscA family
HGO23_06935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HGO23_06940	COG0443	Heat shock 70 kDa protein
HGO23_06945	COG0633	Ferredoxin
HGO23_06950	COG2975	iron-sulfur cluster assembly
HGO23_06955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGO23_06965	COG2373	Large extracellular alpha-helical protein
HGO23_06970	COG4953	penicillin-binding protein 1C
HGO23_06980	COG0105	UTP biosynthetic process
HGO23_06985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGO23_07000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HGO23_07005	COG0124	histidyl-tRNA synthetase
HGO23_07010	COG2976	Protein conserved in bacteria
HGO23_07015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGO23_07020	COG1160	GTP binding
HGO23_07040	COG0408	coproporphyrinogen oxidase activity
HGO23_07045	COG0456	acetyltransferase
HGO23_07065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HGO23_07070	COG4208	sulfate ABC transporter
HGO23_07075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HGO23_07090	COG1960	acyl-CoA dehydrogenase activity
HGO23_07105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGO23_07145	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGO23_07150	COG2190	(PTS) system
HGO23_07160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_07165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGO23_07175	COG3115	cell septum assembly
HGO23_07180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGO23_07185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGO23_07190	COG3530	Putative quorum-sensing-regulated virulence factor
HGO23_07200	COG0534	Mate efflux family protein
HGO23_07220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGO23_07270	COG0727	PFAM Uncharacterised protein family (UPF0153)
HGO23_07355	COG0582	viral genome integration into host DNA
HGO23_07375	COG3691	Protein conserved in bacteria
HGO23_07380	COG0183	Belongs to the thiolase family
HGO23_07385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGO23_07385	COG1024	Enoyl-CoA hydratase
HGO23_07390	COG2062	phosphohistidine phosphatase, SixA
HGO23_07395	COG2840	Smr protein MutS2
HGO23_07405	COG1228	amidohydrolase
HGO23_07410	COG0010	Belongs to the arginase family
HGO23_07420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HGO23_07425	COG2986	histidine ammonia-lyase
HGO23_07440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGO23_07445	COG0730	response to heat
HGO23_07450	COG3101	peptidyl-lysine hydroxylation
HGO23_07470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGO23_07470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HGO23_07475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGO23_07505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGO23_07510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGO23_07515	COG0101	tRNA pseudouridine synthase activity
HGO23_07520	COG0586	Pfam SNARE associated Golgi protein
HGO23_07525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HGO23_07530	COG0285	dihydrofolate synthase activity
HGO23_07535	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HGO23_07540	COG1286	toxin biosynthetic process
HGO23_07545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGO23_07550	COG0163	prenyltransferase activity
HGO23_07555	COG1090	epimerase
HGO23_07560	COG0625	glutathione transferase activity
HGO23_07585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGO23_07585	COG2070	2-Nitropropane dioxygenase
HGO23_07590	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_07600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGO23_07625	COG1131	(ABC) transporter
HGO23_07635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HGO23_07635	COG3064	Membrane
HGO23_07635	COG1073	alpha beta
HGO23_07650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGO23_07655	COG3138	arginine N-succinyltransferase
HGO23_07660	COG1012	belongs to the aldehyde dehydrogenase family
HGO23_07665	COG3724	N-succinylarginine dihydrolase activity
HGO23_07670	COG2988	succinylglutamate desuccinylase activity
HGO23_07675	COG1113	amino acid transport
HGO23_07680	COG0857	belongs to the CobB CobQ family
HGO23_07680	COG0280	phosphate acetyltransferase
HGO23_07685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGO23_07690	COG3092	negative regulation of chromosome organization
HGO23_07695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGO23_07700	COG0490	domain, Protein
HGO23_07700	COG0471	metal ion transport
HGO23_07715	COG0436	Aminotransferase
HGO23_07720	COG0583	DNA-binding transcription factor activity
HGO23_07725	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGO23_07730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGO23_07735	COG0649	NAD binding
HGO23_07735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGO23_07750	COG1034	ATP synthesis coupled electron transport
HGO23_07755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HGO23_07760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGO23_07765	COG0839	Belongs to the complex I subunit 6 family
HGO23_07770	COG0713	ATP synthesis coupled electron transport
HGO23_07775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGO23_07780	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HGO23_07785	COG1007	ATP synthesis coupled electron transport
HGO23_07800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGO23_07805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_07815	COG3037	sugar-specific permease SgaT UlaA
HGO23_07835	COG2200	EAL domain
HGO23_07835	COG2771	luxR family
HGO23_07840	COG2885	chlorophyll binding
HGO23_07845	COG2199	diguanylate cyclase activity
HGO23_07860	COG1215	transferase activity, transferring glycosyl groups
HGO23_07865	COG0726	polysaccharide deacetylase
HGO23_07865	COG1649	PFAM Uncharacterised BCR, COG1649
HGO23_07870	COG0457	Tetratricopeptide repeat
HGO23_07875	COG1169	isochorismate synthase
HGO23_07880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HGO23_07885	COG0596	Alpha beta hydrolase
HGO23_07890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HGO23_07895	COG1441	menaquinone biosynthetic process
HGO23_07910	COG0814	amino acid
HGO23_07960	COG0642	Histidine kinase
HGO23_07960	COG2198	Histidine kinase
HGO23_07965	COG2197	response regulator
HGO23_07970	COG0784	Response regulator, receiver
HGO23_07970	COG2205	protein histidine kinase activity
HGO23_07980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGO23_07985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGO23_07990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGO23_07995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGO23_08000	COG3023	N-Acetylmuramoyl-L-alanine amidase
HGO23_08015	COG3397	chitin binding
HGO23_08030	COG0210	DNA helicase
HGO23_08035	COG1832	CoA-binding protein
HGO23_08040	COG3785	DNA binding
HGO23_08045	COG1254	Belongs to the acylphosphatase family
HGO23_08050	COG2920	part of a sulfur-relay system
HGO23_08090	COG3423	Transcriptional regulator
HGO23_08095	COG0582	viral genome integration into host DNA
HGO23_08135	COG3306	glycosyltransferase involved in LPS biosynthesis
HGO23_08150	COG3082	Protein of unknown function (DUF1414)
HGO23_08155	COG3081	Nucleoid-associated protein
HGO23_08160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGO23_08165	COG1061	Type III restriction enzyme res subunit
HGO23_08170	COG1187	pseudouridine synthase activity
HGO23_08175	COG2814	Major facilitator Superfamily
HGO23_08185	COG0791	NLP P60 protein
HGO23_08190	COG0671	phosphoesterase, PA-phosphatase related
HGO23_08200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGO23_08210	COG2816	NAD+ diphosphatase activity
HGO23_08215	COG1105	Belongs to the carbohydrate kinase PfkB family
HGO23_08220	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HGO23_08225	COG2855	membrane
HGO23_08230	COG0583	DNA-binding transcription factor activity
HGO23_08235	COG0833	amino acid
HGO23_08245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGO23_08250	COG3842	ATPase activity
HGO23_08255	COG4771	TonB-dependent receptor
HGO23_08265	COG0531	amino acid
HGO23_08270	COG0277	FAD linked oxidase domain protein
HGO23_08275	COG2925	Exonuclease
HGO23_08280	COG2926	Belongs to the UPF0265 family
HGO23_08285	COG0702	epimerase
HGO23_08305	COG1530	ribonuclease E activity
HGO23_08310	COG0564	pseudouridine synthase activity
HGO23_08315	COG0424	maF-like protein
HGO23_08320	COG1399	metal-binding, possibly nucleic acid-binding protein
HGO23_08325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HGO23_08330	COG0416	fatty acid biosynthetic process
HGO23_08335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGO23_08340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGO23_08350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGO23_08355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGO23_08360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGO23_08365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGO23_08370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGO23_08375	COG0470	DNA polymerase III
HGO23_08380	COG0084	hydrolase, TatD family'
HGO23_08385	COG0537	adenosine 5'-monophosphoramidase activity
HGO23_08390	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HGO23_08400	COG1472	Belongs to the glycosyl hydrolase 3 family
HGO23_08405	COG1252	NADH dehydrogenase
HGO23_08415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGO23_08420	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGO23_08425	COG1136	(ABC) transporter
HGO23_08430	COG4591	ABC-type transport system involved in lipoprotein release permease component
HGO23_08440	COG2850	peptidyl-arginine hydroxylation
HGO23_08445	COG2205	protein histidine kinase activity
HGO23_08450	COG0745	RESPONSE REGULATOR receiver
HGO23_08455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGO23_08460	COG2915	High frequency lysogenization protein hflD homolog
HGO23_08465	COG0482	sulfurtransferase activity
HGO23_08475	COG1187	pseudouridine synthase activity
HGO23_08480	COG0538	isocitrate dehydrogenase activity
HGO23_08505	COG1115	amino acid carrier protein
HGO23_08510	COG3023	N-Acetylmuramoyl-L-alanine amidase
HGO23_08515	COG2207	Transcriptional regulator
HGO23_08515	COG3708	Transcriptional regulator
HGO23_08520	COG1113	amino acid transport
HGO23_08535	COG1830	Aldolase
HGO23_08540	COG0826	peptidase U32
HGO23_08545	COG3422	double-strand break repair
HGO23_08550	COG0745	RESPONSE REGULATOR receiver
HGO23_08555	COG2205	protein histidine kinase activity
HGO23_08560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGO23_08565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGO23_08570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGO23_08575	COG3157	Type VI secretion system effector, Hcp
HGO23_08580	COG2239	Acts as a magnesium transporter
HGO23_08590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HGO23_08595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGO23_08600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGO23_08605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGO23_08610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGO23_08620	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGO23_08625	COG1393	Belongs to the ArsC family
HGO23_08630	COG4783	chaperone-mediated protein folding
HGO23_08635	COG0628	permease
HGO23_08640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGO23_08645	COG2716	regulation of RNA biosynthetic process
HGO23_08650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGO23_08655	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HGO23_08660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGO23_08670	COG2707	UPF0756 membrane protein
HGO23_08675	COG1444	tRNA N-acetyltransferase activity
HGO23_08685	COG1876	peptidase activity
HGO23_08690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGO23_08695	COG1393	Belongs to the ArsC family
HGO23_08700	COG2197	response regulator
HGO23_08730	COG1570	exodeoxyribonuclease VII activity
HGO23_08735	COG0517	IMP dehydrogenase activity
HGO23_08735	COG0516	GMP reductase activity
HGO23_08740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HGO23_08740	COG0519	Catalyzes the synthesis of GMP from XMP
HGO23_08755	COG2271	Major facilitator Superfamily
HGO23_08760	COG2197	response regulator
HGO23_08770	COG2271	Major facilitator Superfamily
HGO23_08775	COG2226	methyltransferase
HGO23_08785	COG2226	methyltransferase
HGO23_08790	COG1971	Probably functions as a manganese efflux pump
HGO23_08795	COG4811	Protein of unknown function (DUF986)
HGO23_08800	COG3716	PTS system mannose fructose sorbose family IID component
HGO23_08805	COG3715	PTS system
HGO23_08810	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_08810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGO23_08815	COG1760	l-serine dehydratase
HGO23_08820	COG0494	nUDIX hydrolase
HGO23_08830	COG3140	Belongs to the UPF0181 family
HGO23_08850	COG1528	Iron-storage protein
HGO23_08855	COG2372	response to copper ion
HGO23_08860	COG1276	copper resistance
HGO23_08870	COG1956	GAF domain-containing protein
HGO23_08875	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HGO23_08885	COG0501	Belongs to the peptidase M48B family
HGO23_08890	COG1823	symporter activity
HGO23_08895	COG1988	membrane-bound metal-dependent
HGO23_08905	COG3001	Fructosamine kinase
HGO23_08910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGO23_08915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGO23_08920	COG1121	(ABC) transporter
HGO23_08925	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGO23_08945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGO23_08950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGO23_08955	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGO23_08970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGO23_08970	COG0072	phenylalanine-tRNA ligase activity
HGO23_08975	COG0776	regulation of translation
HGO23_08980	COG4139	cobalamin transport
HGO23_08985	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HGO23_08990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGO23_08995	COG0463	Glycosyl transferase, family 2
HGO23_09000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGO23_09000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGO23_09005	COG0726	polysaccharide deacetylase
HGO23_09010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HGO23_09015	COG2076	Multidrug Resistance protein
HGO23_09020	COG2076	Multidrug Resistance protein
HGO23_09025	COG0791	NLP P60 protein
HGO23_09030	COG0095	Lipoate-protein ligase
HGO23_09035	COG2207	Transcriptional regulator
HGO23_09045	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HGO23_09050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGO23_09055	COG4558	Periplasmic binding protein
HGO23_09060	COG3720	iron ion transport
HGO23_09070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGO23_09075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HGO23_09080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGO23_09080	COG0574	Belongs to the PEP-utilizing enzyme family
HGO23_09085	COG0628	permease
HGO23_09090	COG0247	lactate metabolic process
HGO23_09090	COG0277	FAD linked oxidase domain protein
HGO23_09095	COG2050	protein possibly involved in aromatic compounds catabolism
HGO23_09100	COG1376	ErfK ybiS ycfS ynhG family protein
HGO23_09100	COG1388	LysM domain
HGO23_09105	COG4238	major outer membrane lipoprotein
HGO23_09125	COG0534	Mate efflux family protein
HGO23_09130	COG0307	riboflavin synthase, alpha
HGO23_09135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HGO23_09140	COG2814	Major facilitator Superfamily
HGO23_09145	COG0583	DNA-binding transcription factor activity
HGO23_09150	COG1609	Transcriptional regulator
HGO23_09160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HGO23_09165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGO23_09170	COG0346	lactoylglutathione lyase activity
HGO23_09175	COG3313	Fe-S protein
HGO23_09185	COG3133	Outer membrane lipoprotein
HGO23_09190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HGO23_09195	COG0259	pyridoxamine-phosphate oxidase activity
HGO23_09200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGO23_09205	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HGO23_09215	COG1021	2,3-dihydroxybenzoate-AMP ligase
HGO23_09235	COG2226	methyltransferase
HGO23_09235	COG3433	isochorismatase activity
HGO23_09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGO23_09240	COG1132	(ABC) transporter
HGO23_09245	COG2375	cellular response to nickel ion
HGO23_09245	COG1132	(ABC) transporter
HGO23_09255	COG4771	TonB-dependent receptor
HGO23_09265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGO23_09280	COG4171	peptide transport system, permease
HGO23_09290	COG4166	transmembrane transport
HGO23_09295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HGO23_09300	COG1842	Phage shock protein A
HGO23_09310	COG1983	PspC domain protein
HGO23_09315	COG3106	COG3106 Predicted ATPase
HGO23_09330	COG0515	serine threonine protein kinase
HGO23_09435	COG4166	transmembrane transport
HGO23_09445	COG0598	Magnesium transport protein CorA
HGO23_09450	COG0037	tRNA processing
HGO23_09455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HGO23_09460	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HGO23_09465	COG2186	Transcriptional regulator
HGO23_09470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGO23_09475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGO23_09490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGO23_09495	COG3139	Protein of unknown function (DUF1315)
HGO23_09500	COG1335	isochorismatase
HGO23_09505	COG0252	asparaginase activity
HGO23_09510	COG0616	signal peptide processing
HGO23_09515	COG0778	Nitroreductase
HGO23_09520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGO23_09525	COG0708	Exodeoxyribonuclease III
HGO23_09540	COG0788	formyltetrahydrofolate deformylase activity
HGO23_09545	COG3012	SEC-C Motif Domain Protein
HGO23_09550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGO23_09600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGO23_09605	COG0444	Belongs to the ABC transporter superfamily
HGO23_09610	COG4608	Belongs to the ABC transporter superfamily
HGO23_09615	COG3099	Belongs to the UPF0263 family
HGO23_09620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGO23_09640	COG2917	probably involved in intracellular septation
HGO23_09655	COG3047	cAMP biosynthetic process
HGO23_09665	COG0159	tryptophan synthase activity
HGO23_09670	COG0133	tryptophan synthase activity
HGO23_09675	COG0134	indole-3-glycerol-phosphate synthase activity
HGO23_09675	COG0135	phosphoribosylanthranilate isomerase activity
HGO23_09680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HGO23_09710	COG0009	L-threonylcarbamoyladenylate synthase
HGO23_09715	COG1187	pseudouridine synthase activity
HGO23_09720	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HGO23_09725	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_09730	COG0616	signal peptide processing
HGO23_09745	COG2808	Putative FMN-binding domain
HGO23_09755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HGO23_09765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HGO23_09770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HGO23_09775	COG0284	orotidine-5'-phosphate decarboxylase activity
HGO23_09780	COG0023	Translation Initiation Factor
HGO23_09785	COG2366	antibiotic biosynthetic process
HGO23_09820	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HGO23_09830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGO23_09840	COG4659	FMN binding
HGO23_09850	COG4656	Part of a membrane complex involved in electron transport
HGO23_09860	COG4657	Part of a membrane complex involved in electron transport
HGO23_09870	COG0673	inositol 2-dehydrogenase activity
HGO23_09875	COG0385	Bile acid
HGO23_09880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HGO23_09885	COG5339	Protein conserved in bacteria
HGO23_09890	COG1482	cell wall glycoprotein biosynthetic process
HGO23_09895	COG0114	fumarate hydratase activity
HGO23_09915	COG4633	Protein conserved in bacteria
HGO23_09930	COG2837	iron assimilation
HGO23_09935	COG1940	carbohydrate kinase activity
HGO23_09940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HGO23_09955	COG4221	oxidoreductase activity
HGO23_09970	COG1012	belongs to the aldehyde dehydrogenase family
HGO23_09990	COG3152	Membrane
HGO23_09995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGO23_10000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGO23_10005	COG0157	Belongs to the NadC ModD family
HGO23_10010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HGO23_10015	COG1104	cysteine desulfurase activity
HGO23_10020	COG1827	regulation of RNA biosynthetic process
HGO23_10050	COG2986	histidine ammonia-lyase
HGO23_10055	COG2153	protein acetylation
HGO23_10120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGO23_10140	COG0577	efflux transmembrane transporter activity
HGO23_10140	COG1136	(ABC) transporter
HGO23_10145	COG1136	(ABC) transporter
HGO23_10165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGO23_10185	COG1902	pentaerythritol trinitrate reductase activity
HGO23_10190	COG0456	acetyltransferase
HGO23_10210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HGO23_10240	COG1846	Transcriptional regulator
HGO23_10260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGO23_10275	COG2814	Major facilitator Superfamily
HGO23_10280	COG0814	amino acid
HGO23_10295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGO23_10300	COG0589	response to stress
HGO23_10305	COG4974	Belongs to the 'phage' integrase family
HGO23_10325	COG1069	ribulokinase activity
HGO23_10340	COG1492	cobalamin metabolic process
HGO23_10405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HGO23_10415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGO23_10415	COG1587	Uroporphyrinogen-III synthase
HGO23_10460	COG3121	Chaperone
HGO23_10485	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HGO23_10490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HGO23_10500	COG0531	amino acid
HGO23_10510	COG1643	Atp-dependent helicase
HGO23_10515	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HGO23_10520	COG3784	Protein of unknown function (DUF1318)
HGO23_10535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGO23_10540	COG2911	Protein conserved in bacteria
HGO23_10545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGO23_10550	COG3187	Heat shock protein
HGO23_10560	COG2983	Belongs to the UPF0260 family
HGO23_10565	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGO23_10570	COG2951	lytic endotransglycosylase activity
HGO23_10575	COG3100	YcgL domain-containing protein
HGO23_10580	COG0850	regulation of cytokinetic process
HGO23_10585	COG2894	cell division
HGO23_10590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HGO23_10595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HGO23_10600	COG0318	PFAM AMP-dependent synthetase and ligase
HGO23_10605	COG3065	identical protein binding
HGO23_10615	COG1199	ATP-dependent helicase activity
HGO23_10620	COG0251	oxidation-reduction process
HGO23_10625	COG2076	Multidrug Resistance protein
HGO23_10630	COG2076	Multidrug Resistance protein
HGO23_10635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HGO23_10640	COG1737	Transcriptional regulator
HGO23_10645	COG0469	pyruvate kinase activity
HGO23_10655	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HGO23_10665	COG1560	Kdo2-lipid A biosynthetic process
HGO23_10670	COG0739	heme binding
HGO23_10675	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HGO23_10680	COG1121	(ABC) transporter
HGO23_10685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGO23_10690	COG3111	PFAM Bacterial OB fold (BOF) protein
HGO23_10695	COG2255	four-way junction helicase activity
HGO23_10700	COG0632	four-way junction helicase activity
HGO23_10705	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HGO23_10710	COG0217	transcriptional regulatory protein
HGO23_10715	COG0494	nUDIX hydrolase
HGO23_10720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGO23_10725	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HGO23_10730	COG2226	methyltransferase
HGO23_10735	COG0500	methyltransferase
HGO23_10740	COG3142	Participates in the control of copper homeostasis
HGO23_10745	COG0018	arginyl-trna synthetase
HGO23_10750	COG0728	peptidoglycan biosynthetic process
HGO23_10755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGO23_10760	COG0477	Major facilitator Superfamily
HGO23_10770	COG3381	protein complex oligomerization
HGO23_10775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGO23_10790	COG1454	alcohol dehydrogenase
HGO23_10795	COG0604	alcohol dehydrogenase
HGO23_10795	COG3321	synthase
HGO23_10800	COG0165	Argininosuccinate lyase
HGO23_10805	COG1279	arginine transmembrane transporter activity
HGO23_10825	COG2378	regulation of single-species biofilm formation
HGO23_10830	COG0154	amidase activity
HGO23_10835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGO23_10840	COG0659	secondary active sulfate transmembrane transporter activity
HGO23_10855	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HGO23_10860	COG2912	Transglutaminase-like superfamily
HGO23_10865	COG2890	protein-(glutamine-N5) methyltransferase activity
HGO23_10870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGO23_10875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGO23_10880	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HGO23_10885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGO23_10890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGO23_10910	COG0193	aminoacyl-tRNA hydrolase activity
HGO23_10915	COG0012	GTP binding
HGO23_10940	COG0076	glutamate decarboxylase activity
HGO23_10980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HGO23_11000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGO23_11000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGO23_11005	COG3716	PTS system mannose fructose sorbose family IID component
HGO23_11010	COG3715	PTS system
HGO23_11015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGO23_11020	COG2222	sugar isomerase
HGO23_11035	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HGO23_11045	COG0579	oxidoreductase
HGO23_11060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGO23_11065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGO23_11070	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGO23_11115	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HGO23_11135	COG1271	oxidase subunit
HGO23_11140	COG1294	oxidase, subunit
HGO23_11155	COG2356	endonuclease I
HGO23_11200	COG0589	response to stress
HGO23_11205	COG0531	amino acid
HGO23_11210	COG1982	Orn Lys Arg decarboxylase major
HGO23_11230	COG2197	response regulator
HGO23_11235	COG0322	excinuclease ABC activity
HGO23_11240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGO23_11275	COG5301	cellulose 1,4-beta-cellobiosidase activity
HGO23_11355	COG4695	Portal protein
HGO23_11465	COG2801	Transposase and inactivated derivatives
HGO23_11510	COG5301	cellulose 1,4-beta-cellobiosidase activity
HGO23_11520	COG0475	glutathione-regulated potassium exporter activity
HGO23_11530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGO23_11540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGO23_11555	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_11555	COG3321	synthase
HGO23_11555	COG4221	oxidoreductase activity
HGO23_11555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGO23_11560	COG3321	synthase
HGO23_11560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGO23_11560	COG0300	oxidoreductase activity
HGO23_11560	COG4221	oxidoreductase activity
HGO23_11570	COG4221	oxidoreductase activity
HGO23_11570	COG3321	synthase
HGO23_11570	COG0300	oxidoreductase activity
HGO23_11570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGO23_11575	COG2070	2-Nitropropane dioxygenase
HGO23_11575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGO23_11600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGO23_11600	COG4221	oxidoreductase activity
HGO23_11600	COG3321	synthase
HGO23_11600	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_11655	COG1113	amino acid transport
HGO23_11695	COG1191	sigma factor activity
HGO23_11705	COG0506	proline dehydrogenase activity
HGO23_11705	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HGO23_11705	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HGO23_11710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGO23_11755	COG1677	Flagellar hook-basal body complex protein FliE
HGO23_11775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGO23_11780	COG1317	bacterial-type flagellum organization
HGO23_11785	COG1157	protein secretion by the type III secretion system
HGO23_11795	COG3144	bacterial-type flagellum assembly
HGO23_11800	COG1580	Controls the rotational direction of flagella during chemotaxis
HGO23_11845	COG1028	Short-chain dehydrogenase reductase Sdr
HGO23_11850	COG3133	Outer membrane lipoprotein
HGO23_11885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGO23_11890	COG1256	bacterial-type flagellum assembly
HGO23_11900	COG1706	bacterial-type flagellum-dependent cell motility
HGO23_11905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HGO23_11930	COG1558	bacterial-type flagellum-dependent cell motility
HGO23_11935	COG1815	bacterial-type flagellum-dependent cell motility
HGO23_11980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGO23_11985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGO23_12000	COG1115	amino acid carrier protein
HGO23_12015	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HGO23_12020	COG0745	RESPONSE REGULATOR receiver
HGO23_12025	COG2201	protein-glutamate methylesterase activity
HGO23_12030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HGO23_12035	COG0840	transmembrane signaling receptor activity
HGO23_12040	COG0840	transmembrane signaling receptor activity
HGO23_12045	COG0835	chemotaxis
HGO23_12050	COG0643	Histidine kinase
HGO23_12050	COG2198	Histidine kinase
HGO23_12055	COG1360	Flagellar Motor Protein
HGO23_12060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGO23_12080	COG1285	pathogenesis
HGO23_12115	COG0418	dihydroorotase activity
HGO23_12130	COG1054	Belongs to the UPF0176 family
HGO23_12135	COG1560	Kdo2-lipid A biosynthetic process
HGO23_12155	COG1304	FMN binding
HGO23_12160	COG3545	Serine hydrolase
HGO23_12195	COG3070	regulator of competence-specific genes
HGO23_12210	COG3120	sequence-specific DNA binding
HGO23_12215	COG1067	ATP-dependent peptidase activity
HGO23_12220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGO23_12225	COG3130	regulation of translation
HGO23_12230	COG3009	Protein conserved in bacteria
HGO23_12235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HGO23_12235	COG3008	intermembrane lipid transfer
HGO23_12240	COG2995	paraquat-inducible protein a
HGO23_12245	COG0488	(ABC) transporter
HGO23_12250	COG0116	Belongs to the methyltransferase superfamily
HGO23_12250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HGO23_12260	COG0167	dihydroorotate dehydrogenase activity
HGO23_12265	COG0308	aminopeptidase N
HGO23_12270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGO23_12275	COG0017	Asparaginyl-tRNA synthetase
HGO23_12280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HGO23_12285	COG1448	Aminotransferase
HGO23_12290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGO23_12295	COG3108	Peptidase M15
HGO23_12300	COG2989	Protein conserved in bacteria
HGO23_12305	COG3700	Belongs to the class B bacterial acid phosphatase family
HGO23_12310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HGO23_12315	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HGO23_12320	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
HGO23_12325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HGO23_12330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HGO23_12335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HGO23_12340	COG2835	tetraacyldisaccharide 4'-kinase activity
HGO23_12345	COG1663	tetraacyldisaccharide 4'-kinase activity
HGO23_12350	COG1132	(ABC) transporter
HGO23_12355	COG2333	competence protein COMEC
HGO23_12355	COG0658	competence protein
HGO23_12360	COG0776	regulation of translation
HGO23_12365	COG0539	negative regulation of cytoplasmic translation
HGO23_12370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HGO23_12375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGO23_12380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HGO23_12390	COG0252	asparaginase activity
HGO23_12395	COG1944	ATP diphosphatase activity
HGO23_12405	COG1882	Formate acetyltransferase
HGO23_12410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HGO23_12415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGO23_12420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGO23_12425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGO23_12430	COG1674	ftsk spoiiie
HGO23_12430	COG3107	peptidoglycan biosynthetic process
HGO23_12435	COG1522	sequence-specific DNA binding
HGO23_12440	COG0492	ferredoxin-NADP+ reductase activity
HGO23_12450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HGO23_12455	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HGO23_12460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HGO23_12465	COG0542	response to heat
HGO23_12470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HGO23_12475	COG1278	Cold shock
HGO23_12480	COG2431	L-lysine efflux transmembrane transporter activity
HGO23_12485	COG1126	abc transporter atp-binding protein
HGO23_12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGO23_12495	COG4215	(ABC) transporter
HGO23_12500	COG4160	amino acid transport
HGO23_12505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGO23_12525	COG0671	phosphoesterase, PA-phosphatase related
HGO23_12530	COG0814	amino acid
HGO23_12535	COG1686	Belongs to the peptidase S11 family
HGO23_12540	COG0625	glutathione transferase activity
HGO23_12545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGO23_12550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HGO23_12555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGO23_12555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGO23_12560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HGO23_12560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGO23_12565	COG0131	Imidazoleglycerol-phosphate dehydratase
HGO23_12565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HGO23_12570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGO23_12575	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HGO23_12580	COG0107	imidazoleglycerol-phosphate synthase activity
HGO23_12585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HGO23_12585	COG0140	phosphoribosyl-ATP diphosphatase activity
HGO23_12590	COG1454	alcohol dehydrogenase
HGO23_12595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HGO23_12600	COG1253	flavin adenine dinucleotide binding
HGO23_12610	COG2982	Protein involved in outer membrane biogenesis
HGO23_12615	COG0717	Belongs to the dCTP deaminase family
HGO23_12620	COG0572	uridine kinase
HGO23_12625	COG0489	protein tyrosine kinase activity
HGO23_12630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGO23_12630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGO23_12635	COG1380	Effector of murein hydrolase LrgA
HGO23_12640	COG1346	cytolysis
HGO23_12645	COG0295	cytidine deaminase activity
HGO23_12650	COG0281	malic enzyme
HGO23_12655	COG2949	membrane
HGO23_12660	COG2311	Membrane
HGO23_12665	COG0302	gtp cyclohydrolase
HGO23_12670	COG0477	Major facilitator Superfamily
HGO23_12685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGO23_12690	COG0488	(ABC) transporter
HGO23_12695	COG0673	inositol 2-dehydrogenase activity
HGO23_12705	COG2807	transmembrane transport
HGO23_12780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGO23_12850	COG1484	DNA-dependent DNA replication
HGO23_13060	COG4386	tail sheath protein
HGO23_13100	COG4381	Mu-like prophage protein gp46
HGO23_13115	COG5301	cellulose 1,4-beta-cellobiosidase activity
HGO23_13140	COG5006	permease, DMT superfamily
HGO23_13150	COG2824	Alkylphosphonate utilization operon protein PhnA
HGO23_13155	COG1199	ATP-dependent helicase activity
HGO23_13165	COG2897	thiosulfate sulfurtransferase activity
HGO23_13170	COG2261	transglycosylase associated protein
HGO23_13175	COG2873	o-acetylhomoserine
HGO23_13180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGO23_13185	COG0513	Belongs to the DEAD box helicase family
HGO23_13190	COG1309	transcriptional regulator
HGO23_13195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGO23_13200	COG1131	(ABC) transporter
HGO23_13205	COG0842	Transport permease protein
HGO23_13210	COG0842	Transport permease protein
HGO23_13220	COG0670	Belongs to the BI1 family
HGO23_13225	COG0314	molybdopterin synthase activity
HGO23_13230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HGO23_13235	COG0315	cyclic pyranopterin monophosphate synthase activity
HGO23_13240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGO23_13245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HGO23_13250	COG0556	nucleotide-excision repair
HGO23_13260	COG2226	methyltransferase
HGO23_13265	COG0156	8-amino-7-oxononanoate synthase activity
HGO23_13270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGO23_13275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGO23_13285	COG2706	6-phosphogluconolactonase activity
HGO23_13290	COG0561	phosphatase activity
HGO23_13295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HGO23_13300	COG4149	molybdate abc transporter
HGO23_13305	COG0725	ABC transporter, periplasmic molybdate-binding protein
HGO23_13315	COG2005	Transcriptional regulator
HGO23_13315	COG3585	molybdate ion transport
HGO23_13320	COG1119	ATPase activity
HGO23_13330	COG0588	phosphoglycerate mutase activity
HGO23_13335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGO23_13340	COG3201	nicotinamide mononucleotide transporter
HGO23_13350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HGO23_13355	COG2885	chlorophyll binding
HGO23_13360	COG0823	Involved in the tonB-independent uptake of proteins
HGO23_13365	COG3064	Membrane
HGO23_13365	COG3064	Membrane
HGO23_13370	COG0848	biopolymer transport protein
HGO23_13375	COG0811	peptide transport
HGO23_13380	COG0824	Thioesterase
HGO23_13385	COG3790	cyd operon protein YbgE
HGO23_13390	COG4890	Cyd operon protein YbgT
HGO23_13395	COG1294	oxidase, subunit
HGO23_13400	COG1271	oxidase subunit
HGO23_13405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HGO23_13410	COG0045	succinate-CoA ligase (ADP-forming) activity
HGO23_13415	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGO23_13420	COG0567	Dehydrogenase, E1 component
HGO23_13435	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HGO23_13445	COG0372	Belongs to the citrate synthase family
HGO23_13455	COG2814	Major facilitator Superfamily
HGO23_13470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGO23_13485	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HGO23_13490	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HGO23_13495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HGO23_13500	COG2205	protein histidine kinase activity
HGO23_13505	COG0033	Phosphoglucomutase
HGO23_13510	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HGO23_13515	COG0596	Alpha beta hydrolase
HGO23_13525	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HGO23_13525	COG1073	alpha beta
HGO23_13525	COG3064	Membrane
HGO23_13540	COG0531	amino acid
HGO23_13550	COG3064	Membrane
HGO23_13550	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HGO23_13550	COG1073	alpha beta
HGO23_13555	COG2994	toxin metabolic process
HGO23_13575	COG2274	protein secretion by the type I secretion system
HGO23_13580	COG2207	Transcriptional regulator
HGO23_13580	COG1917	Cupin 2, conserved barrel domain protein
HGO23_13585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGO23_13605	COG0716	FMN binding
HGO23_13610	COG0735	belongs to the Fur family
HGO23_13620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HGO23_13625	COG2190	(PTS) system
HGO23_13625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGO23_13625	COG1263	PTS System
HGO23_13630	COG0363	glucosamine-6-phosphate deaminase activity
HGO23_13635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGO23_13640	COG1940	carbohydrate kinase activity
HGO23_13640	COG1846	Transcriptional regulator
HGO23_13685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGO23_13690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGO23_13695	COG1702	phosphate starvation-inducible protein PhoH
HGO23_13700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGO23_13705	COG4535	Mg2 and Co2 transporter CorC
HGO23_13710	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HGO23_13720	COG0765	amino acid transport
HGO23_13725	COG0765	amino acid transport
HGO23_13730	COG1126	abc transporter atp-binding protein
HGO23_13735	COG0495	leucyl-tRNA aminoacylation
HGO23_13740	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HGO23_13745	COG1466	dna polymerase III delta subunit
HGO23_13755	COG0799	negative regulation of ribosome biogenesis
HGO23_13760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HGO23_13765	COG0768	penicillin binding
HGO23_13770	COG0772	Belongs to the SEDS family
HGO23_13775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGO23_13780	COG1686	Belongs to the peptidase S11 family
HGO23_13785	COG2921	Belongs to the UPF0250 family
HGO23_13790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGO23_13795	COG0321	lipoyl(octanoyl) transferase activity
HGO23_13800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGO23_13805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGO23_13815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGO23_13820	COG4175	Glycine betaine
HGO23_13825	COG4176	ABC-type proline glycine betaine transport system permease component
HGO23_13830	COG2113	Glycine betaine
HGO23_13840	COG1846	Transcriptional regulator
HGO23_13845	COG1566	PFAM secretion protein HlyD family protein
HGO23_13850	COG2814	Major facilitator Superfamily
HGO23_13860	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HGO23_13865	COG0076	glutamate decarboxylase activity
HGO23_13870	COG4114	ferric iron reductase
HGO23_13875	COG1120	ATPase activity
HGO23_13885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGO23_13890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGO23_13895	COG4773	Receptor
HGO23_13900	COG4264	IucA IucC family
HGO23_13905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGO23_13910	COG3148	PFAM DTW domain containing protein
HGO23_13915	COG0045	succinate-CoA ligase (ADP-forming) activity
HGO23_13915	COG1042	CoA-binding domain protein
HGO23_13915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGO23_13920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGO23_13925	COG5544	Lipoprotein
HGO23_13955	COG0542	response to heat
HGO23_13960	COG1496	oxidoreductase activity
HGO23_13965	COG0564	pseudouridine synthase activity
HGO23_13970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGO23_13980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HGO23_13985	COG0077	Prephenate dehydratase
HGO23_13985	COG1605	Chorismate mutase
HGO23_13990	COG0287	Prephenate dehydrogenase
HGO23_13990	COG1605	Chorismate mutase
HGO23_13995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HGO23_14000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HGO23_14005	COG0335	large ribosomal subunit rRNA binding
HGO23_14010	COG0336	Belongs to the RNA methyltransferase TrmD family
HGO23_14015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGO23_14025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGO23_14030	COG4137	Cytochrome C assembly protein
HGO23_14035	COG4536	flavin adenine dinucleotide binding
HGO23_14040	COG1854	S-ribosylhomocysteine lyase activity
HGO23_14045	COG2918	glutathione biosynthetic process
HGO23_14075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HGO23_14080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGO23_14095	COG2814	Major facilitator Superfamily
HGO23_14100	COG0318	PFAM AMP-dependent synthetase and ligase
HGO23_14100	COG0204	Acyl-transferase
HGO23_14105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGO23_14110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HGO23_14115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGO23_14125	COG1073	alpha beta
HGO23_14130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HGO23_14135	COG2195	Cleaves the N-terminal amino acid of tripeptides
HGO23_14140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGO23_14145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HGO23_14150	COG1309	transcriptional regulator
HGO23_14155	COG1012	belongs to the aldehyde dehydrogenase family
HGO23_14160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HGO23_14175	COG1629	transport
HGO23_14180	COG2991	Protein conserved in bacteria
HGO23_14185	COG1477	protein flavinylation
HGO23_14195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HGO23_14200	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HGO23_14205	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HGO23_14210	COG1805	sodium ion transport
HGO23_14215	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HGO23_14220	COG3034	peptidoglycan biosynthetic process
HGO23_14225	COG0121	glutamine amidotransferase
HGO23_14235	COG1960	acyl-CoA dehydrogenase activity
HGO23_14245	COG0583	DNA-binding transcription factor activity
HGO23_14250	COG0583	DNA-binding transcription factor activity
HGO23_14265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGO23_14270	COG0189	ligase activity
HGO23_14275	COG1678	Uncharacterized ACR, COG1678
HGO23_14280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGO23_14285	COG2805	Type II/IV secretion system protein
HGO23_14290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGO23_14295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGO23_14300	COG0762	integral membrane protein
HGO23_14305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGO23_14310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGO23_14315	COG4607	ABC-type enterochelin transport system periplasmic component
HGO23_14325	COG2066	Belongs to the glutaminase family
HGO23_14330	COG3171	Protein conserved in bacteria
HGO23_14335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGO23_14340	COG1194	a g-specific adenine glycosylase
HGO23_14345	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HGO23_14350	COG0741	lytic transglycosylase activity
HGO23_14360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGO23_14420	COG3501	Rhs element vgr protein
HGO23_14430	COG3209	COG3209 Rhs family protein
HGO23_14445	COG3620	sequence-specific DNA binding
HGO23_14450	COG0358	DNA primase activity
HGO23_14465	COG3209	COG3209 Rhs family protein
HGO23_14610	COG3423	Transcriptional regulator
HGO23_14645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGO23_14665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HGO23_14695	COG0305	Participates in initiation and elongation during chromosome replication
HGO23_14710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HGO23_14855	COG2801	Transposase and inactivated derivatives
HGO23_14915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGO23_14920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGO23_14925	COG2031	fatty acid transporter
HGO23_14955	COG0372	Belongs to the citrate synthase family
HGO23_14980	COG3038	cytochrome b561
HGO23_14985	COG2353	YceI-like domain
HGO23_15025	COG2841	Protein conserved in bacteria
HGO23_15080	COG5301	cellulose 1,4-beta-cellobiosidase activity
HGO23_15110	COG3772	lysozyme
HGO23_15165	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGO23_15175	COG0318	PFAM AMP-dependent synthetase and ligase
HGO23_15180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HGO23_15190	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HGO23_15215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGO23_15215	COG1522	sequence-specific DNA binding
HGO23_15225	COG5301	cellulose 1,4-beta-cellobiosidase activity
HGO23_15245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HGO23_15255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGO23_15260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGO23_15265	COG4974	Belongs to the 'phage' integrase family
HGO23_15270	COG0716	FMN binding
HGO23_15290	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HGO23_15295	COG0354	folic acid binding
HGO23_15310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGO23_15310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGO23_15315	COG0509	glycine decarboxylation via glycine cleavage system
HGO23_15320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGO23_15325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGO23_15330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGO23_15335	COG0006	proline dipeptidase activity
HGO23_15340	COG3079	Belongs to the UPF0149 family
HGO23_15355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGO23_15360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGO23_15365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HGO23_15370	COG0583	DNA-binding transcription factor activity
HGO23_15375	COG2968	Membrane
HGO23_15420	COG0494	nUDIX hydrolase
HGO23_15425	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HGO23_15435	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HGO23_15440	COG0237	dephospho-CoA kinase activity
HGO23_15450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HGO23_15455	COG4969	Belongs to the N-Me-Phe pilin family
HGO23_15490	COG0473	3-isopropylmalate dehydrogenase activity
HGO23_15510	COG1022	Amp-dependent synthetase and ligase
HGO23_15515	COG0028	Belongs to the TPP enzyme family
HGO23_15530	COG2001	Belongs to the MraZ family
HGO23_15535	COG0275	rRNA processing
HGO23_15540	COG3116	cell division
HGO23_15545	COG0768	penicillin binding
HGO23_15550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGO23_15555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGO23_15560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGO23_15565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGO23_15570	COG0772	Belongs to the SEDS family
HGO23_15575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGO23_15580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGO23_15585	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGO23_15590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HGO23_15595	COG0849	cell division
HGO23_15605	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HGO23_15620	COG0653	protein targeting
HGO23_15635	COG3023	N-Acetylmuramoyl-L-alanine amidase
HGO23_15640	COG3725	Membrane protein required for beta-lactamase induction
HGO23_15645	COG2186	Transcriptional regulator
HGO23_15650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HGO23_15655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGO23_15660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGO23_15675	COG3112	Uncharacterised protein family (UPF0231)
HGO23_15680	COG0668	transmembrane transport
HGO23_15695	COG4533	DNA binding
HGO23_15700	COG3066	DNA modification
HGO23_15710	COG0242	peptide deformylase activity
HGO23_15715	COG0626	cystathionine gamma-synthase activity
HGO23_15745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGO23_15750	COG2977	Belongs to the P-Pant transferase superfamily
HGO23_15755	COG0066	3-isopropylmalate dehydratase activity
HGO23_15760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HGO23_15765	COG0583	DNA-binding transcription factor activity
HGO23_15775	COG1881	PFAM PEBP family protein
HGO23_15780	COG0010	Belongs to the arginase family
HGO23_15795	COG1166	arginine decarboxylase activity
HGO23_15800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGO23_15805	COG3091	SprT-like family
HGO23_15820	COG1301	dicarboxylic acid transport
HGO23_15825	COG0215	cysteine-tRNA ligase activity
HGO23_15830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGO23_15835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGO23_15840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HGO23_15845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGO23_15875	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HGO23_15895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HGO23_15900	COG4181	ATPase activity
HGO23_15905	COG2755	lipolytic protein G-D-S-L family
HGO23_15910	COG0300	oxidoreductase activity
HGO23_15915	COG3118	belongs to the thioredoxin family
HGO23_15920	COG0330	HflC and HflK could
HGO23_15930	COG0789	Transcriptional regulator
HGO23_15940	COG3735	TraB family
HGO23_15950	COG0737	Belongs to the 5'-nucleotidase family
HGO23_15955	COG2223	nitrite transmembrane transporter activity
HGO23_15960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGO23_15960	COG4651	solute:proton antiporter activity
HGO23_15965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGO23_15970	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HGO23_15975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HGO23_15980	COG0563	adenylate kinase activity
HGO23_15985	COG0326	Molecular chaperone. Has ATPase activity
HGO23_15990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGO23_15995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGO23_16005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGO23_16020	COG1196	nuclear chromosome segregation
HGO23_16020	COG3264	Mechanosensitive ion channel
HGO23_16025	COG1309	transcriptional regulator
HGO23_16030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGO23_16035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HGO23_16055	COG1946	Acyl-CoA thioesterase
HGO23_16060	COG0004	ammonium transporteR
HGO23_16065	COG0347	Belongs to the P(II) protein family
HGO23_16070	COG1132	(ABC) transporter
HGO23_16075	COG1132	(ABC) transporter
HGO23_16080	COG1522	sequence-specific DNA binding
HGO23_16085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGO23_16090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGO23_16095	COG0824	Thioesterase
HGO23_16100	COG1555	photosystem II stabilization
HGO23_16105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGO23_16115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGO23_16120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGO23_16130	COG0544	peptidyl-prolyl cis-trans isomerase activity
HGO23_16135	COG0271	Belongs to the BolA IbaG family
HGO23_16140	COG3056	Lipoprotein
HGO23_16145	COG2223	nitrite transmembrane transporter activity
HGO23_16155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGO23_16160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGO23_16165	COG1845	cytochrome c oxidase, subunit III
HGO23_16170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGO23_16175	COG0109	protoheme IX farnesyltransferase activity
HGO23_16180	COG2814	Major facilitator Superfamily
HGO23_16185	COG1666	GTP binding
HGO23_16190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGO23_16195	COG0693	protein deglycase activity
HGO23_16200	COG0301	tRNA thio-modification
HGO23_16200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGO23_16210	COG0142	geranyltranstransferase activity
HGO23_16215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGO23_16225	COG0805	protein transport
HGO23_16230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGO23_16235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGO23_16240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HGO23_16245	COG3165	ubiquinone biosynthetic process from chorismate
HGO23_16250	COG2226	methyltransferase
HGO23_16255	COG1322	Protein conserved in bacteria
HGO23_16260	COG0586	Pfam SNARE associated Golgi protein
HGO23_16270	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HGO23_16275	COG2610	gluconate transmembrane transporter activity
HGO23_16280	COG2610	gluconate transmembrane transporter activity
HGO23_16285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGO23_16290	COG0583	DNA-binding transcription factor activity
HGO23_16300	COG0025	NhaP-type Na H and K H
HGO23_16305	COG2252	PERMEase
HGO23_16310	COG0534	Mate efflux family protein
HGO23_16330	COG0814	amino acid
HGO23_16335	COG0582	viral genome integration into host DNA
HGO23_16340	COG0523	cobalamin synthesis protein
HGO23_16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGO23_16355	COG2879	small protein
HGO23_16360	COG1966	Carbon starvation protein
HGO23_16365	COG0024	Methionine aminopeptidase
HGO23_16375	COG3177	Filamentation induced by cAMP protein fic
HGO23_16380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGO23_16395	COG4942	peptidase
HGO23_16395	COG1388	LysM domain
HGO23_16400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HGO23_16405	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HGO23_16410	COG0585	pseudouridine synthase activity
HGO23_16415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGO23_16420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HGO23_16425	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HGO23_16430	COG0529	Catalyzes the synthesis of activated sulfate
HGO23_16435	COG2895	sulfate adenylyltransferase (ATP) activity
HGO23_16440	COG0175	sulfate reduction
HGO23_16445	COG1648	precorrin-2 dehydrogenase activity
HGO23_16445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGO23_16450	COG0175	sulfate reduction
HGO23_16455	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGO23_16460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HGO23_16465	COG0720	synthase
HGO23_16470	COG0602	queuosine metabolic process
HGO23_16480	COG3021	interspecies interaction between organisms
HGO23_16515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HGO23_16520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGO23_16530	COG1464	Belongs to the NlpA lipoprotein family
HGO23_16540	COG1720	tRNA m6t6A37 methyltransferase activity
HGO23_16545	COG0442	prolyl-tRNA aminoacylation
HGO23_16550	COG3015	lipoprotein NlpE involved in copper resistance
HGO23_16555	COG4568	rho-dependent transcription termination
HGO23_16565	COG0037	tRNA processing
HGO23_16575	COG1268	BioY protein
HGO23_16580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGO23_16585	COG1122	ATPase activity
HGO23_16600	COG0825	malonyl-CoA metabolic process
HGO23_16610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGO23_16615	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGO23_16620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGO23_16625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGO23_16630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HGO23_16645	COG0750	zinc metalloprotease
HGO23_16650	COG0575	Belongs to the CDS family
HGO23_16655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGO23_16660	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HGO23_16665	COG0233	cytoplasmic translational termination
HGO23_16670	COG0528	UMP kinase activity
HGO23_16675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HGO23_16680	COG0052	Belongs to the universal ribosomal protein uS2 family
HGO23_16695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HGO23_16720	COG0564	pseudouridine synthase activity
HGO23_16725	COG3098	single-species biofilm formation
HGO23_16740	COG0688	phosphatidylethanolamine metabolic process
HGO23_16750	COG1132	(ABC) transporter
HGO23_16755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGO23_16755	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGO23_16760	COG1611	Belongs to the LOG family
HGO23_16765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGO23_16790	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HGO23_16800	COG2363	Small membrane protein
HGO23_16805	COG0583	DNA-binding transcription factor activity
HGO23_16810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGO23_16815	COG2166	iron-sulfur cluster assembly
HGO23_16820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HGO23_16825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HGO23_16855	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGO23_16860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HGO23_16860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HGO23_16865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGO23_16870	COG1074	ATP-dependent DNA helicase activity
HGO23_16875	COG1025	Belongs to the peptidase M16 family
HGO23_16880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HGO23_16900	COG2165	general secretion pathway protein
HGO23_16905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HGO23_16910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGO23_16920	COG0494	nUDIX hydrolase
HGO23_16925	COG4143	(ABC) transporter
HGO23_16930	COG1178	ABC-type Fe3 transport system permease component
HGO23_16935	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HGO23_16945	COG0417	DNA replication proofreading
HGO23_16950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGO23_16955	COG0564	pseudouridine synthase activity
HGO23_16960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HGO23_16965	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HGO23_16970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGO23_16975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HGO23_16980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGO23_16985	COG2967	ApaG domain
HGO23_16990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGO23_17010	COG2132	Multicopper oxidase
HGO23_17015	COG0204	Acyl-transferase
HGO23_17020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGO23_17030	COG3150	esterase
HGO23_17035	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HGO23_17040	COG0494	nUDIX hydrolase
HGO23_17050	COG5463	Belongs to the UPF0441 family
HGO23_17055	COG0754	glutathionylspermidine amidase activity
HGO23_17060	COG3384	dioxygenase
HGO23_17065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGO23_17075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HGO23_17075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HGO23_17080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HGO23_17085	COG3025	triphosphatase activity
HGO23_17090	COG4991	sh3 domain protein
HGO23_17095	COG0617	tRNA 3'-terminal CCA addition
HGO23_17100	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HGO23_17105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGO23_17130	COG1609	Transcriptional regulator
HGO23_17135	COG3265	gluconokinase activity
HGO23_17140	COG2610	gluconate transmembrane transporter activity
HGO23_17145	COG2992	FlgJ-related protein
HGO23_17155	COG3853	Toxic anion resistance protein (TelA)
HGO23_17185	COG1177	transmembrane transport
HGO23_17205	COG1105	Belongs to the carbohydrate kinase PfkB family
HGO23_17210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGO23_17210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGO23_17210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HGO23_17235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGO23_17240	COG1904	glucuronate isomerase
HGO23_17245	COG0246	Mannitol dehydrogenase
HGO23_17260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HGO23_17270	COG2186	Transcriptional regulator
HGO23_17275	COG1794	racemase activity, acting on amino acids and derivatives
HGO23_17280	COG1301	dicarboxylic acid transport
HGO23_17360	COG0582	viral genome integration into host DNA
HGO23_17370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGO23_17380	COG0795	lipopolysaccharide-transporting ATPase activity
HGO23_17385	COG0795	lipopolysaccharide-transporting ATPase activity
HGO23_17390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGO23_17395	COG2927	DNA polymerase III (CHI subunit)
HGO23_17400	COG0525	valine-tRNA ligase activity
HGO23_17405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGO23_17410	COG0765	amino acid transport
HGO23_17415	COG1126	abc transporter atp-binding protein
HGO23_17420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGO23_17430	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HGO23_17435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGO23_17445	COG3541	Predicted nucleotidyltransferase
HGO23_17450	COG1690	Belongs to the RtcB family
HGO23_17450	COG1690	Belongs to the RtcB family
HGO23_17470	COG0540	Belongs to the ATCase OTCase family
HGO23_17500	COG0583	DNA-binding transcription factor activity
HGO23_17515	COG1222	aaa ATPase
HGO23_17605	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HGO23_17620	COG0602	queuosine metabolic process
HGO23_17625	COG3787	Belongs to the UPF0306 family
HGO23_17635	COG2827	Endonuclease containing a URI domain
HGO23_17640	COG3153	acetyltransferase
HGO23_17665	COG3275	phosphorelay sensor kinase activity
HGO23_17675	COG0513	Belongs to the DEAD box helicase family
HGO23_17690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGO23_17695	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGO23_17700	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGO23_17705	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGO23_17710	COG0195	Participates in both transcription termination and antitermination
HGO23_17715	COG0779	Required for maturation of 30S ribosomal subunits
HGO23_17730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGO23_17735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGO23_17740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGO23_17745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGO23_17750	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HGO23_17755	COG1534	Rna-binding protein
HGO23_17765	COG2027	D-alanyl-D-alanine carboxypeptidase
HGO23_17770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGO23_17775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGO23_17780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGO23_17785	COG0142	geranyltranstransferase activity
HGO23_17800	COG3423	Transcriptional regulator
HGO23_17805	COG0039	L-malate dehydrogenase activity
HGO23_17815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGO23_17820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HGO23_17830	COG2105	PFAM AIG2 family protein
HGO23_17840	COG0729	surface antigen
HGO23_17845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGO23_17850	COG1253	flavin adenine dinucleotide binding
HGO23_17860	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HGO23_17870	COG0545	Peptidyl-prolyl cis-trans isomerase
HGO23_17875	COG0359	binds to the 23S rRNA
HGO23_17880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGO23_17885	COG2965	DNA replication, synthesis of RNA primer
HGO23_17890	COG0360	Binds together with S18 to 16S ribosomal RNA
HGO23_17895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGO23_17900	COG0557	exoribonuclease II activity
HGO23_17905	COG1959	2 iron, 2 sulfur cluster binding
HGO23_17925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HGO23_17930	COG0330	HflC and HflK could
HGO23_17935	COG0330	HflC and HflK could
HGO23_17945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGO23_17950	COG1923	regulation of RNA biosynthetic process
HGO23_17955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HGO23_17960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HGO23_17970	COG0802	atpase or kinase
HGO23_17980	COG2368	4-hydroxyphenylacetate
HGO23_18015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HGO23_18020	COG1162	GTPase activity
HGO23_18025	COG0688	phosphatidylethanolamine metabolic process
HGO23_18030	COG3264	Mechanosensitive ion channel
HGO23_18030	COG1511	domain protein
HGO23_18050	COG1609	Transcriptional regulator
HGO23_18055	COG0477	Major facilitator Superfamily
HGO23_18065	COG0561	phosphatase activity
HGO23_18070	COG2267	carboxylic ester hydrolase activity
HGO23_18075	COG0514	ATP-dependent DNA helicase (RecQ)
HGO23_18080	COG2050	protein possibly involved in aromatic compounds catabolism
HGO23_18085	COG3501	Rhs element vgr protein
HGO23_18120	COG1487	ribonuclease activity
HGO23_18130	COG0598	Magnesium transport protein CorA
HGO23_18135	COG0210	DNA helicase
HGO23_18140	COG1011	Hydrolase
HGO23_18150	COG3159	Protein conserved in bacteria
HGO23_18155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HGO23_18165	COG1965	Belongs to the frataxin family
HGO23_18175	COG0181	hydroxymethylbilane synthase activity
HGO23_18185	COG2959	enzyme of heme biosynthesis
HGO23_18190	COG3071	HemY protein
HGO23_18220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HGO23_18230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGO23_18235	COG2244	polysaccharide biosynthetic process
HGO23_18240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGO23_18245	COG0456	acetyltransferase
HGO23_18250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HGO23_18255	COG1088	dTDP-glucose 4,6-dehydratase activity
HGO23_18260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HGO23_18265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HGO23_18270	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HGO23_18275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGO23_18280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGO23_18285	COG3118	belongs to the thioredoxin family
HGO23_18290	COG0513	Belongs to the DEAD box helicase family
HGO23_18295	COG0248	Ppx GppA phosphatase
HGO23_18300	COG0210	DNA helicase
HGO23_18310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HGO23_18320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HGO23_18325	COG0129	dihydroxy-acid dehydratase activity
HGO23_18330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGO23_18335	COG3978	acetolactate synthase activity
HGO23_18355	COG3085	chromosome segregation
HGO23_18395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HGO23_18405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGO23_18410	COG0009	L-threonylcarbamoyladenylate synthase
HGO23_18415	COG0551	DNA topoisomerase type I activity
HGO23_18420	COG0758	DNA mediated transformation
HGO23_18425	COG0242	peptide deformylase activity
HGO23_18430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGO23_18435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGO23_18435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGO23_18440	COG0569	domain protein
HGO23_18450	COG3036	rescue of stalled ribosome
HGO23_18465	COG3547	Transposase (IS116 IS110 IS902 family)
HGO23_18470	COG0789	Transcriptional regulator
HGO23_18475	COG0203	ribosomal protein L17
HGO23_18480	COG0202	RNA polymerase activity
HGO23_18485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGO23_18495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGO23_18500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGO23_18505	COG0201	protein transport
HGO23_18510	COG0200	Binds to the 23S rRNA
HGO23_18515	COG1841	ribosomal large subunit assembly
HGO23_18520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGO23_18525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGO23_18530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGO23_18535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGO23_18540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGO23_18545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGO23_18550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HGO23_18555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HGO23_18560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGO23_18570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGO23_18585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HGO23_18590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGO23_18595	COG0089	rRNA binding
HGO23_18600	COG0088	Forms part of the polypeptide exit tunnel
HGO23_18605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGO23_18610	COG0051	transcription antitermination factor activity, RNA binding
HGO23_18625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGO23_18650	COG1072	(Pantothenic acid kinase))
HGO23_18660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGO23_18695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HGO23_18700	COG4206	TonB-dependent receptor
HGO23_18705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGO23_18720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGO23_18730	COG0165	Argininosuccinate lyase
HGO23_18735	COG0137	argininosuccinate synthase activity
HGO23_18745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HGO23_18750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGO23_18770	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HGO23_18775	COG0460	homoserine dehydrogenase
HGO23_18775	COG0527	aspartate kinase activity
HGO23_18780	COG0626	cystathionine gamma-synthase activity
HGO23_18785	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
HGO23_18790	COG0254	rRNA binding
HGO23_18795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGO23_18800	COG1609	Transcriptional regulator
HGO23_18805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGO23_18810	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGO23_18815	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HGO23_18825	COG1575	Belongs to the MenA family. Type 1 subfamily
HGO23_18830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HGO23_18835	COG3074	FtsZ-dependent cytokinesis
HGO23_18845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGO23_18860	COG3152	Membrane
HGO23_18870	COG0149	triose-phosphate isomerase activity
HGO23_18875	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HGO23_18880	COG0205	6-phosphofructokinase activity
HGO23_18885	COG4589	Belongs to the CDS family
HGO23_18895	COG3678	ATP-independent chaperone mediated protein folding
HGO23_18900	COG0745	RESPONSE REGULATOR receiver
HGO23_18905	COG2205	protein histidine kinase activity
HGO23_18915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGO23_18930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGO23_18935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGO23_18975	COG3335	DDE superfamily endonuclease
HGO23_18980	COG0438	transferase activity, transferring glycosyl groups
HGO23_19005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HGO23_19020	COG2246	polysaccharide biosynthetic process
HGO23_19035	COG1045	serine acetyltransferase
HGO23_19040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGO23_19045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HGO23_19050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGO23_19055	COG4942	peptidase
HGO23_19060	COG2861	carbohydrate metabolic process
HGO23_19065	COG1063	alcohol dehydrogenase
HGO23_19070	COG0156	8-amino-7-oxononanoate synthase activity
HGO23_19075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGO23_19085	COG0859	PFAM glycosyl transferase family 9
HGO23_19100	COG0438	transferase activity, transferring glycosyl groups
HGO23_19120	COG1519	Transferase
HGO23_19130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGO23_19135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HGO23_19150	COG0438	transferase activity, transferring glycosyl groups
HGO23_19160	COG0438	transferase activity, transferring glycosyl groups
HGO23_19165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HGO23_19175	COG2003	Belongs to the UPF0758 family
HGO23_19180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGO23_19185	COG0756	dUTP diphosphatase activity
HGO23_19190	COG1309	transcriptional regulator
HGO23_19195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGO23_19200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HGO23_19205	COG1561	YicC-like family, N-terminal region
HGO23_19315	COG3645	SOS response
HGO23_19330	COG2801	Transposase and inactivated derivatives
HGO23_19335	COG2264	protein methyltransferase activity
HGO23_19370	COG0477	Major facilitator Superfamily
HGO23_19375	COG0583	DNA-binding transcription factor activity
HGO23_19395	COG5464	transposase or invertase
HGO23_19410	COG1368	sulfuric ester hydrolase activity
HGO23_19420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HGO23_19455	COG3093	addiction module antidote protein HigA
HGO23_19460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGO23_19465	COG0706	membrane insertase activity
HGO23_19470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGO23_19475	COG0594	ribonuclease P activity