locus-tag	class	description
XDD1_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XDD1_0002	COG0592	DNA-directed DNA polymerase activity
XDD1_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XDD1_0004	COG0187	DNA topoisomerase II activity
XDD1_0009	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XDD1_0013	COG2255	four-way junction helicase activity
XDD1_0028	COG3335	DDE superfamily endonuclease
XDD1_0030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XDD1_0031	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XDD1_0033	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XDD1_0034	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XDD1_0035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XDD1_0036	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XDD1_0037	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XDD1_0038	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XDD1_0040	COG0356	it plays a direct role in the translocation of protons across the membrane
XDD1_0041	COG3312	ion transport
XDD1_0042	COG0357	Ribosomal RNA small subunit methyltransferase G
XDD1_0043	COG0445	tRNA wobble uridine modification
XDD1_0044	COG0716	FMN binding
XDD1_0045	COG1522	sequence-specific DNA binding
XDD1_0046	COG2502	aspartate--ammonia ligase
XDD1_0047	COG2425	protein containing a von Willebrand factor type A (vWA) domain
XDD1_0048	COG0714	Associated with various cellular activities
XDD1_0049	COG1129	ABC transporter
XDD1_0050	COG1172	Belongs to the binding-protein-dependent transport system permease family
XDD1_0051	COG1879	ABC-type sugar transport system periplasmic component
XDD1_0052	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_0053	COG1609	Transcriptional regulator
XDD1_0054	COG0477	Major facilitator Superfamily
XDD1_0058	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XDD1_0059	COG3162	membrane
XDD1_0061	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XDD1_0062	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XDD1_0064	COG2258	MOSC domain
XDD1_0065	COG0180	Tryptophanyl-tRNA synthetase
XDD1_0066	COG0546	phosphoglycolate phosphatase activity
XDD1_0067	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XDD1_0070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XDD1_0071	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XDD1_0072	COG4796	Type ii and iii secretion system protein
XDD1_0076	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XDD1_0077	COG0494	nUDIX hydrolase
XDD1_0079	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
XDD1_0080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XDD1_0081	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
XDD1_0082	COG2814	Major facilitator Superfamily
XDD1_0085	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XDD1_0089	COG0583	DNA-binding transcription factor activity
XDD1_0090	COG2081	HI0933 family
XDD1_0091	COG0306	phosphate transporter
XDD1_0094	COG0589	response to stress
XDD1_0097	COG0742	ribosomal rna small subunit methyltransferase
XDD1_0100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XDD1_0104	COG0366	Alpha amylase catalytic
XDD1_0105	COG1263	PTS System
XDD1_0105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_0107	COG3327	negative regulation of DNA-templated transcription, initiation
XDD1_0108	COG0583	DNA-binding transcription factor activity
XDD1_0109	COG3335	DDE superfamily endonuclease
XDD1_0113	COG1561	YicC-like family, N-terminal region
XDD1_0115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XDD1_0116	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XDD1_0118	COG1309	transcriptional regulator
XDD1_0119	COG0756	dUTP diphosphatase activity
XDD1_0120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XDD1_0122	COG2003	Belongs to the UPF0758 family
XDD1_0125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XDD1_0127	COG0438	transferase activity, transferring glycosyl groups
XDD1_0129	COG0438	transferase activity, transferring glycosyl groups
XDD1_0132	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XDD1_0133	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XDD1_0135	COG1519	Transferase
XDD1_0136	COG0859	PFAM glycosyl transferase family 9
XDD1_0138	COG0438	transferase activity, transferring glycosyl groups
XDD1_0140	COG1215	transferase activity, transferring glycosyl groups
XDD1_0141	COG1216	Glycosyl transferase, family 2
XDD1_0144	COG0859	PFAM glycosyl transferase family 9
XDD1_0146	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_0147	COG0156	8-amino-7-oxononanoate synthase activity
XDD1_0148	COG1063	alcohol dehydrogenase
XDD1_0149	COG2861	carbohydrate metabolic process
XDD1_0150	COG4942	peptidase
XDD1_0155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XDD1_0156	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XDD1_0157	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XDD1_0158	COG1045	serine acetyltransferase
XDD1_0159	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XDD1_0164	COG1086	Polysaccharide biosynthesis protein
XDD1_0165	COG0438	transferase activity, transferring glycosyl groups
XDD1_0166	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XDD1_0167	COG0662	Cupin 2, conserved barrel domain protein
XDD1_0167	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
XDD1_0171	COG2205	protein histidine kinase activity
XDD1_0172	COG0745	RESPONSE REGULATOR receiver
XDD1_0173	COG3678	ATP-independent chaperone mediated protein folding
XDD1_0183	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XDD1_0184	COG0149	triose-phosphate isomerase activity
XDD1_0187	COG3152	Membrane
XDD1_0189	COG2814	Major facilitator Superfamily
XDD1_0190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XDD1_0192	COG3074	FtsZ-dependent cytokinesis
XDD1_0193	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XDD1_0194	COG1575	Belongs to the MenA family. Type 1 subfamily
XDD1_0195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XDD1_0196	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XDD1_0197	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XDD1_0198	COG1609	Transcriptional regulator
XDD1_0199	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XDD1_0201	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
XDD1_0202	COG0626	cystathionine gamma-synthase activity
XDD1_0203	COG0527	aspartate kinase activity
XDD1_0203	COG0460	homoserine dehydrogenase
XDD1_0204	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XDD1_0205	COG0583	DNA-binding transcription factor activity
XDD1_0206	COG2814	Major facilitator Superfamily
XDD1_0209	COG2814	Major facilitator Superfamily
XDD1_0215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XDD1_0216	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XDD1_0218	COG0137	argininosuccinate synthase activity
XDD1_0219	COG0165	Argininosuccinate lyase
XDD1_0221	COG3335	DDE superfamily endonuclease
XDD1_0229	COG3547	Transposase (IS116 IS110 IS902 family)
XDD1_0238	COG0442	prolyl-tRNA aminoacylation
XDD1_0241	COG3335	DDE superfamily endonuclease
XDD1_0249	COG3547	Transposase (IS116 IS110 IS902 family)
XDD1_0258	COG3335	DDE superfamily endonuclease
XDD1_0260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XDD1_0263	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XDD1_0264	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XDD1_0272	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XDD1_0274	COG1072	(Pantothenic acid kinase))
XDD1_0277	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XDD1_0279	COG0051	transcription antitermination factor activity, RNA binding
XDD1_0280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XDD1_0281	COG0088	Forms part of the polypeptide exit tunnel
XDD1_0282	COG0089	rRNA binding
XDD1_0283	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XDD1_0284	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XDD1_0285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XDD1_0287	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XDD1_0288	COG0255	Belongs to the universal ribosomal protein uL29 family
XDD1_0289	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XDD1_0290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XDD1_0291	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XDD1_0292	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XDD1_0293	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XDD1_0294	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XDD1_0295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XDD1_0296	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XDD1_0297	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XDD1_0298	COG1841	ribosomal large subunit assembly
XDD1_0299	COG0200	Binds to the 23S rRNA
XDD1_0300	COG0201	protein transport
XDD1_0301	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XDD1_0302	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XDD1_0303	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XDD1_0304	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XDD1_0305	COG0202	RNA polymerase activity
XDD1_0306	COG0203	ribosomal protein L17
XDD1_0307	COG0789	Transcriptional regulator
XDD1_0308	COG3036	rescue of stalled ribosome
XDD1_0309	COG0569	domain protein
XDD1_0310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XDD1_0310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XDD1_0311	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XDD1_0312	COG0242	peptide deformylase activity
XDD1_0314	COG0758	DNA mediated transformation
XDD1_0315	COG0551	DNA topoisomerase type I activity
XDD1_0316	COG0009	L-threonylcarbamoyladenylate synthase
XDD1_0317	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XDD1_0319	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XDD1_0326	COG0583	DNA-binding transcription factor activity
XDD1_0327	COG3085	chromosome segregation
XDD1_0330	COG3978	acetolactate synthase activity
XDD1_0331	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XDD1_0332	COG0129	dihydroxy-acid dehydratase activity
XDD1_0334	COG2814	Major facilitator Superfamily
XDD1_0335	COG1566	PFAM secretion protein HlyD family protein
XDD1_0337	COG0583	DNA-binding transcription factor activity
XDD1_0338	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XDD1_0341	COG0248	Ppx GppA phosphatase
XDD1_0342	COG0513	Belongs to the DEAD box helicase family
XDD1_0343	COG3118	belongs to the thioredoxin family
XDD1_0345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XDD1_0346	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XDD1_0347	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XDD1_0348	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
XDD1_0349	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XDD1_0350	COG1088	dTDP-glucose 4,6-dehydratase activity
XDD1_0351	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
XDD1_0352	COG0456	acetyltransferase
XDD1_0353	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XDD1_0354	COG2244	polysaccharide biosynthetic process
XDD1_0355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XDD1_0357	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XDD1_0358	COG1113	amino acid transport
XDD1_0360	COG3071	HemY protein
XDD1_0361	COG2959	enzyme of heme biosynthesis
XDD1_0363	COG0181	hydroxymethylbilane synthase activity
XDD1_0366	COG1965	Belongs to the frataxin family
XDD1_0367	COG5567	small periplasmic lipoprotein
XDD1_0368	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XDD1_0371	COG1011	Hydrolase
XDD1_0373	COG0598	Magnesium transport protein CorA
XDD1_0379	COG2050	protein possibly involved in aromatic compounds catabolism
XDD1_0381	COG0514	ATP-dependent DNA helicase (RecQ)
XDD1_0382	COG2267	carboxylic ester hydrolase activity
XDD1_0383	COG0561	phosphatase activity
XDD1_0385	COG0477	Major facilitator Superfamily
XDD1_0386	COG1609	Transcriptional regulator
XDD1_0389	COG3152	Membrane
XDD1_0390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XDD1_0395	COG2814	Major facilitator Superfamily
XDD1_0397	COG3264	Mechanosensitive ion channel
XDD1_0397	COG1511	domain protein
XDD1_0398	COG0688	phosphatidylethanolamine metabolic process
XDD1_0399	COG1162	GTPase activity
XDD1_0403	COG2814	Major facilitator Superfamily
XDD1_0410	COG0583	DNA-binding transcription factor activity
XDD1_0411	COG0477	Major facilitator Superfamily
XDD1_0413	COG3033	Beta-eliminating lyase
XDD1_0414	COG1960	acyl-CoA dehydrogenase activity
XDD1_0415	COG2368	4-hydroxyphenylacetate
XDD1_0416	COG0802	atpase or kinase
XDD1_0417	COG0860	N-Acetylmuramoyl-L-alanine amidase
XDD1_0418	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XDD1_0419	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XDD1_0420	COG1923	regulation of RNA biosynthetic process
XDD1_0422	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XDD1_0424	COG0330	HflC and HflK could
XDD1_0425	COG0330	HflC and HflK could
XDD1_0426	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XDD1_0428	COG0557	exoribonuclease II activity
XDD1_0430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XDD1_0431	COG0360	Binds together with S18 to 16S ribosomal RNA
XDD1_0432	COG2965	DNA replication, synthesis of RNA primer
XDD1_0434	COG0359	binds to the 23S rRNA
XDD1_0438	COG0545	Peptidyl-prolyl cis-trans isomerase
XDD1_0440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
XDD1_0443	COG1598	PFAM Uncharacterised protein family UPF0150
XDD1_0444	COG1724	mRNA binding
XDD1_0445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XDD1_0448	COG2105	PFAM AIG2 family protein
XDD1_0449	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XDD1_0450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XDD1_0452	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XDD1_0453	COG1438	arginine binding
XDD1_0455	COG0039	L-malate dehydrogenase activity
XDD1_0456	COG3423	Transcriptional regulator
XDD1_0459	COG0142	geranyltranstransferase activity
XDD1_0461	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XDD1_0462	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XDD1_0463	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XDD1_0466	COG3609	addiction module antidote protein, CC2985 family
XDD1_0467	COG2027	D-alanyl-D-alanine carboxypeptidase
XDD1_0469	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XDD1_0470	COG1534	Rna-binding protein
XDD1_0471	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XDD1_0472	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XDD1_0473	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XDD1_0474	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XDD1_0475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XDD1_0476	COG0779	Required for maturation of 30S ribosomal subunits
XDD1_0477	COG0195	Participates in both transcription termination and antitermination
XDD1_0478	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XDD1_0479	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XDD1_0480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XDD1_0484	COG0513	Belongs to the DEAD box helicase family
XDD1_0488	COG3275	phosphorelay sensor kinase activity
XDD1_0489	COG1388	LysM domain
XDD1_0489	COG1470	cell adhesion involved in biofilm formation
XDD1_0490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_0494	COG3153	acetyltransferase
XDD1_0497	COG3787	Belongs to the UPF0306 family
XDD1_0498	COG0602	queuosine metabolic process
XDD1_0502	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
XDD1_0503	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XDD1_0511	COG0540	Belongs to the ATCase OTCase family
XDD1_0514	COG1234	tRNA 3'-trailer cleavage
XDD1_0519	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_0520	COG0765	amino acid transport
XDD1_0521	COG1126	abc transporter atp-binding protein
XDD1_0522	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_0523	COG2828	Protein conserved in bacteria
XDD1_0528	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
XDD1_0529	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XDD1_0530	COG0626	cystathionine gamma-synthase activity
XDD1_0531	COG1757	Na H antiporter
XDD1_0532	COG2515	1-aminocyclopropane-1-carboxylate deaminase
XDD1_0535	COG3335	DDE superfamily endonuclease
XDD1_0544	COG5464	transposase or invertase
XDD1_0550	COG3335	DDE superfamily endonuclease
XDD1_0556	COG2337	Toxic component of a toxin-antitoxin (TA) module
XDD1_0557	COG2336	PFAM SpoVT AbrB
XDD1_0559	COG5464	transposase or invertase
XDD1_0564	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XDD1_0565	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XDD1_0569	COG0488	(ABC) transporter
XDD1_0584	COG0179	Fumarylacetoacetate (FAA) hydrolase
XDD1_0585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XDD1_0591	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XDD1_0592	COG1518	maintenance of DNA repeat elements
XDD1_0598	COG1203	CRISPR-associated helicase, Cas3
XDD1_0606	COG1609	Transcriptional regulator
XDD1_0607	COG3265	gluconokinase activity
XDD1_0608	COG2610	gluconate transmembrane transporter activity
XDD1_0616	COG3335	DDE superfamily endonuclease
XDD1_0618	COG2992	FlgJ-related protein
XDD1_0621	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_0630	COG1358	cellular component organization or biogenesis
XDD1_0633	COG2862	Uncharacterized protein family, UPF0114
XDD1_0637	COG2382	esterase
XDD1_0638	COG0697	spore germination
XDD1_0641	COG1309	transcriptional regulator
XDD1_0642	COG4232	protein-disulfide reductase activity
XDD1_0643	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XDD1_0644	COG1027	Aspartate ammonia-lyase
XDD1_0647	COG0459	protein refolding
XDD1_0649	COG1509	lysine 2,3-aminomutase activity
XDD1_0650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XDD1_0651	COG2076	Multidrug Resistance protein
XDD1_0652	COG3423	Transcriptional regulator
XDD1_0655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_0657	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_0659	COG3316	Transposase and inactivated derivatives
XDD1_0661	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XDD1_0663	COG0795	lipopolysaccharide-transporting ATPase activity
XDD1_0664	COG0795	lipopolysaccharide-transporting ATPase activity
XDD1_0665	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XDD1_0666	COG2927	DNA polymerase III (CHI subunit)
XDD1_0667	COG0525	valine-tRNA ligase activity
XDD1_0674	COG1280	lysine exporter protein (LysE YggA)
XDD1_0675	COG1309	transcriptional regulator
XDD1_0677	COG3335	DDE superfamily endonuclease
XDD1_0681	COG1396	sequence-specific DNA binding
XDD1_0686	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XDD1_0687	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_0688	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XDD1_0693	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XDD1_0694	COG1177	transmembrane transport
XDD1_0695	COG1176	ABC-type spermidine putrescine transport system, permease component I
XDD1_0696	COG3842	ATPase activity
XDD1_0702	COG2205	protein histidine kinase activity
XDD1_0704	COG3727	T/G mismatch-specific endonuclease activity
XDD1_0709	COG3093	addiction module antidote protein HigA
XDD1_0711	COG0583	DNA-binding transcription factor activity
XDD1_0712	COG1301	dicarboxylic acid transport
XDD1_0718	COG3335	DDE superfamily endonuclease
XDD1_0721	COG2813	Specifically methylates the guanine in position
XDD1_0722	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
XDD1_0723	COG0456	acetyltransferase
XDD1_0724	COG3620	sequence-specific DNA binding
XDD1_0725	COG3550	peptidyl-serine autophosphorylation
XDD1_0726	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XDD1_0728	COG4667	esterase of the alpha-beta hydrolase superfamily
XDD1_0729	COG0084	hydrolase, TatD family'
XDD1_0730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XDD1_0731	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
XDD1_0732	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
XDD1_0733	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
XDD1_0734	COG0813	purine-nucleoside phosphorylase activity
XDD1_0735	COG3539	Fimbrial protein
XDD1_0736	COG3188	usher protein
XDD1_0737	COG3121	Chaperone
XDD1_0742	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XDD1_0744	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XDD1_0750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XDD1_0751	COG1047	Peptidyl-prolyl cis-trans
XDD1_0752	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XDD1_0753	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XDD1_0754	COG0196	riboflavin kinase activity
XDD1_0755	COG0268	Binds directly to 16S ribosomal RNA
XDD1_0756	COG0583	DNA-binding transcription factor activity
XDD1_0757	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XDD1_0759	COG0484	heat shock protein binding
XDD1_0760	COG0443	Heat shock 70 kDa protein
XDD1_0761	COG1584	GPR1 FUN34 yaaH family protein
XDD1_0775	COG0521	Mo-molybdopterin cofactor biosynthetic process
XDD1_0776	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XDD1_0777	COG3022	response to hydroperoxide
XDD1_0779	COG0083	homoserine kinase activity
XDD1_0781	COG0745	RESPONSE REGULATOR receiver
XDD1_0782	COG3045	CreA protein
XDD1_0784	COG2207	Transcriptional regulator
XDD1_0784	COG3708	Transcriptional regulator
XDD1_0785	COG0406	alpha-ribazole phosphatase activity
XDD1_0786	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
XDD1_0787	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XDD1_0788	COG0741	lytic transglycosylase activity
XDD1_0789	COG0488	(ABC) transporter
XDD1_0790	COG1126	abc transporter atp-binding protein
XDD1_0792	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
XDD1_0793	COG0560	Phosphoserine phosphatase
XDD1_0794	COG3726	membrane protein affecting hemolysin expression
XDD1_0796	COG0656	L-ascorbic acid biosynthetic process
XDD1_0797	COG0586	Pfam SNARE associated Golgi protein
XDD1_0799	COG0811	peptide transport
XDD1_0800	COG0848	biopolymer transport protein
XDD1_0803	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_0804	COG2723	6-phospho-beta-galactosidase activity
XDD1_0806	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
XDD1_0811	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XDD1_0812	COG2974	May be involved in recombination
XDD1_0813	COG1940	carbohydrate kinase activity
XDD1_0814	COG0737	Belongs to the 5'-nucleotidase family
XDD1_0821	COG0419	ATPase involved in DNA repair
XDD1_0822	COG0420	3'-5' exonuclease activity
XDD1_0824	COG0745	RESPONSE REGULATOR receiver
XDD1_0825	COG5002	protein histidine kinase activity
XDD1_0826	COG1114	Component of the transport system for branched-chain amino acids
XDD1_0827	COG0733	neurotransmitter:sodium symporter activity
XDD1_0829	COG0450	alkyl hydroperoxide reductase
XDD1_0831	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
XDD1_0832	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XDD1_0833	COG0343	queuine tRNA-ribosyltransferase activity
XDD1_0834	COG1862	Preprotein translocase
XDD1_0836	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XDD1_0837	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XDD1_0838	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XDD1_0838	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XDD1_0839	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XDD1_0840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XDD1_0841	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XDD1_0842	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
XDD1_0843	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
XDD1_0847	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XDD1_0848	COG1757	Na H antiporter
XDD1_0849	COG1609	Transcriptional regulator
XDD1_0857	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XDD1_0858	COG0142	geranyltranstransferase activity
XDD1_0860	COG0301	tRNA thio-modification
XDD1_0860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XDD1_0861	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XDD1_0862	COG1666	GTP binding
XDD1_0863	COG2814	Major facilitator Superfamily
XDD1_0864	COG0109	protoheme IX farnesyltransferase activity
XDD1_0865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XDD1_0866	COG1845	cytochrome c oxidase, subunit III
XDD1_0867	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XDD1_0868	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XDD1_0871	COG2223	nitrite transmembrane transporter activity
XDD1_0872	COG3056	Lipoprotein
XDD1_0873	COG0271	Belongs to the BolA IbaG family
XDD1_0876	COG0740	serine-type endopeptidase activity
XDD1_0877	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XDD1_0878	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XDD1_0880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XDD1_0882	COG1555	photosystem II stabilization
XDD1_0883	COG0824	Thioesterase
XDD1_0884	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XDD1_0886	COG1522	sequence-specific DNA binding
XDD1_0887	COG1132	(ABC) transporter
XDD1_0888	COG1132	(ABC) transporter
XDD1_0889	COG0347	Belongs to the P(II) protein family
XDD1_0890	COG0004	ammonium transporteR
XDD1_0891	COG1946	Acyl-CoA thioesterase
XDD1_0897	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_0898	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_0899	COG1309	transcriptional regulator
XDD1_0900	COG3264	Mechanosensitive ion channel
XDD1_0900	COG1196	nuclear chromosome segregation
XDD1_0903	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XDD1_0905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XDD1_0907	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XDD1_0908	COG0326	Molecular chaperone. Has ATPase activity
XDD1_0910	COG0563	adenylate kinase activity
XDD1_0912	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XDD1_0913	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XDD1_0914	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_0915	COG4651	solute:proton antiporter activity
XDD1_0915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XDD1_0916	COG2223	nitrite transmembrane transporter activity
XDD1_0917	COG0737	Belongs to the 5'-nucleotidase family
XDD1_0920	COG3735	TraB family
XDD1_0921	COG2217	Heavy metal translocating P-type atpase
XDD1_0922	COG0789	Transcriptional regulator
XDD1_0923	COG1585	Membrane protein implicated in regulation of membrane protease activity
XDD1_0924	COG0330	HflC and HflK could
XDD1_0925	COG3118	belongs to the thioredoxin family
XDD1_0926	COG0300	oxidoreductase activity
XDD1_0927	COG2755	lipolytic protein G-D-S-L family
XDD1_0928	COG4181	ATPase activity
XDD1_0929	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
XDD1_0931	COG0307	riboflavin synthase, alpha
XDD1_0934	COG0446	pyridine nucleotide-disulphide oxidoreductase
XDD1_0936	COG3555	Aspartyl Asparaginyl beta-hydroxylase
XDD1_0937	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XDD1_0938	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
XDD1_0939	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_0940	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XDD1_0942	COG0215	cysteine-tRNA ligase activity
XDD1_0944	COG2501	S4 domain
XDD1_0945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XDD1_0954	COG3657	addiction module killer protein
XDD1_0955	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XDD1_0959	COG3209	COG3209 Rhs family protein
XDD1_0969	COG3209	COG3209 Rhs family protein
XDD1_0972	COG3501	Rhs element vgr protein
XDD1_0979	COG0741	lytic transglycosylase activity
XDD1_0979	COG1388	LysM domain
XDD1_0980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XDD1_0981	COG2226	methyltransferase
XDD1_0983	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XDD1_0987	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XDD1_0988	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XDD1_0992	COG3104	oligopeptide transport
XDD1_0998	COG0259	pyridoxamine-phosphate oxidase activity
XDD1_1000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
XDD1_1005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XDD1_1010	COG1063	alcohol dehydrogenase
XDD1_1011	COG1454	alcohol dehydrogenase
XDD1_1012	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
XDD1_1013	COG2368	4-hydroxyphenylacetate
XDD1_1020	COG3971	2-oxopent-4-enoate hydratase activity
XDD1_1023	COG3384	dioxygenase
XDD1_1024	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_1026	COG0179	Fumarylacetoacetate (FAA) hydrolase
XDD1_1028	COG1846	Transcriptional regulator
XDD1_1036	COG3962	Belongs to the TPP enzyme family
XDD1_1039	COG0673	inositol 2-dehydrogenase activity
XDD1_1040	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XDD1_1041	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_1043	COG3718	enzyme involved in inositol metabolism
XDD1_1050	COG1335	isochorismatase
XDD1_1054	COG3423	Transcriptional regulator
XDD1_1056	COG2267	carboxylic ester hydrolase activity
XDD1_1057	COG0697	spore germination
XDD1_1067	COG0305	Participates in initiation and elongation during chromosome replication
XDD1_1075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_1081	COG3423	Transcriptional regulator
XDD1_1100	COG1388	LysM domain
XDD1_1100	COG1470	cell adhesion involved in biofilm formation
XDD1_1101	COG1522	sequence-specific DNA binding
XDD1_1101	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_1112	COG3209	COG3209 Rhs family protein
XDD1_1112	COG4104	PAAR repeat-containing protein
XDD1_1114	COG3501	Rhs element vgr protein
XDD1_1117	COG2831	hemolysin activation secretion protein
XDD1_1119	COG3210	domain, Protein
XDD1_1132	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XDD1_1133	COG0741	lytic transglycosylase activity
XDD1_1134	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XDD1_1135	COG1194	a g-specific adenine glycosylase
XDD1_1136	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XDD1_1137	COG3171	Protein conserved in bacteria
XDD1_1138	COG2066	Belongs to the glutaminase family
XDD1_1140	COG4607	ABC-type enterochelin transport system periplasmic component
XDD1_1142	COG1881	PFAM PEBP family protein
XDD1_1144	COG0583	DNA-binding transcription factor activity
XDD1_1145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XDD1_1146	COG0066	3-isopropylmalate dehydratase activity
XDD1_1150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XDD1_1151	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XDD1_1152	COG0762	integral membrane protein
XDD1_1153	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XDD1_1154	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XDD1_1155	COG2805	Type II/IV secretion system protein
XDD1_1156	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XDD1_1157	COG1678	Uncharacterized ACR, COG1678
XDD1_1158	COG0189	ligase activity
XDD1_1159	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XDD1_1163	COG0583	DNA-binding transcription factor activity
XDD1_1164	COG0583	DNA-binding transcription factor activity
XDD1_1165	COG0019	diaminopimelate decarboxylase activity
XDD1_1166	COG1960	acyl-CoA dehydrogenase activity
XDD1_1168	COG0121	glutamine amidotransferase
XDD1_1169	COG3034	peptidoglycan biosynthetic process
XDD1_1171	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_1172	COG1805	sodium ion transport
XDD1_1173	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_1174	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_1175	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_1177	COG1477	protein flavinylation
XDD1_1178	COG2991	Protein conserved in bacteria
XDD1_1179	COG1595	DNA-templated transcription, initiation
XDD1_1180	COG1629	transport
XDD1_1182	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
XDD1_1183	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_1184	COG1309	transcriptional regulator
XDD1_1185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XDD1_1187	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
XDD1_1188	COG2195	Cleaves the N-terminal amino acid of tripeptides
XDD1_1189	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
XDD1_1192	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XDD1_1193	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XDD1_1194	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XDD1_1195	COG0204	Acyl-transferase
XDD1_1195	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_1196	COG2814	Major facilitator Superfamily
XDD1_1198	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XDD1_1200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XDD1_1201	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XDD1_1202	COG2918	glutathione biosynthetic process
XDD1_1204	COG4536	flavin adenine dinucleotide binding
XDD1_1205	COG4137	Cytochrome C assembly protein
XDD1_1206	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XDD1_1207	COG0228	four-way junction DNA binding
XDD1_1208	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XDD1_1209	COG0336	Belongs to the RNA methyltransferase TrmD family
XDD1_1210	COG0335	large ribosomal subunit rRNA binding
XDD1_1211	COG0165	Argininosuccinate lyase
XDD1_1213	COG2814	Major facilitator Superfamily
XDD1_1216	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XDD1_1217	COG0287	Prephenate dehydrogenase
XDD1_1217	COG1605	Chorismate mutase
XDD1_1218	COG0077	Prephenate dehydratase
XDD1_1218	COG1605	Chorismate mutase
XDD1_1219	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XDD1_1220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_1221	COG0564	pseudouridine synthase activity
XDD1_1223	COG0542	response to heat
XDD1_1230	COG5544	Lipoprotein
XDD1_1231	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XDD1_1232	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XDD1_1232	COG0045	succinate-CoA ligase (ADP-forming) activity
XDD1_1232	COG1042	CoA-binding domain protein
XDD1_1234	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XDD1_1239	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_1240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_1241	COG1120	ATPase activity
XDD1_1242	COG4114	ferric iron reductase
XDD1_1243	COG0076	glutamate decarboxylase activity
XDD1_1244	COG3486	L-lysine 6-monooxygenase (NADPH) activity
XDD1_1247	COG2814	Major facilitator Superfamily
XDD1_1248	COG1566	PFAM secretion protein HlyD family protein
XDD1_1249	COG1846	Transcriptional regulator
XDD1_1252	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
XDD1_1254	COG2113	Glycine betaine
XDD1_1255	COG4176	ABC-type proline glycine betaine transport system permease component
XDD1_1256	COG4175	Glycine betaine
XDD1_1259	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XDD1_1260	COG1278	Cold shock
XDD1_1261	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XDD1_1262	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XDD1_1263	COG0321	lipoyl(octanoyl) transferase activity
XDD1_1265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XDD1_1266	COG2921	Belongs to the UPF0250 family
XDD1_1267	COG1686	Belongs to the peptidase S11 family
XDD1_1270	COG0772	Belongs to the SEDS family
XDD1_1271	COG0768	penicillin binding
XDD1_1272	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XDD1_1273	COG0799	negative regulation of ribosome biogenesis
XDD1_1275	COG1466	dna polymerase III delta subunit
XDD1_1276	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
XDD1_1277	COG0495	leucyl-tRNA aminoacylation
XDD1_1278	COG1126	abc transporter atp-binding protein
XDD1_1279	COG0765	amino acid transport
XDD1_1280	COG0765	amino acid transport
XDD1_1283	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XDD1_1287	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_1289	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XDD1_1290	COG4535	Mg2 and Co2 transporter CorC
XDD1_1291	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XDD1_1292	COG1702	phosphate starvation-inducible protein PhoH
XDD1_1293	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XDD1_1294	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XDD1_1296	COG1846	Transcriptional regulator
XDD1_1296	COG1940	carbohydrate kinase activity
XDD1_1297	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XDD1_1298	COG0363	glucosamine-6-phosphate deaminase activity
XDD1_1299	COG1263	PTS System
XDD1_1299	COG2190	(PTS) system
XDD1_1299	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_1300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XDD1_1302	COG0735	belongs to the Fur family
XDD1_1303	COG0716	FMN binding
XDD1_1307	COG2207	Transcriptional regulator
XDD1_1307	COG0662	Cupin 2, conserved barrel domain protein
XDD1_1308	COG2274	protein secretion by the type I secretion system
XDD1_1312	COG2994	toxin metabolic process
XDD1_1313	COG3064	Membrane
XDD1_1313	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XDD1_1313	COG1073	alpha beta
XDD1_1316	COG2226	methyltransferase
XDD1_1320	COG2226	methyltransferase
XDD1_1321	COG0596	Alpha beta hydrolase
XDD1_1322	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
XDD1_1323	COG0033	Phosphoglucomutase
XDD1_1326	COG2205	protein histidine kinase activity
XDD1_1327	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XDD1_1328	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XDD1_1329	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XDD1_1333	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XDD1_1334	COG2814	Major facilitator Superfamily
XDD1_1336	COG0372	Belongs to the citrate synthase family
XDD1_1338	COG2009	succinate dehydrogenase
XDD1_1339	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XDD1_1341	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XDD1_1342	COG0567	Dehydrogenase, E1 component
XDD1_1343	COG0508	dehydrogenase complex catalyzes the overall conversion of
XDD1_1344	COG0045	succinate-CoA ligase (ADP-forming) activity
XDD1_1345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XDD1_1346	COG1271	oxidase subunit
XDD1_1347	COG1294	oxidase, subunit
XDD1_1348	COG4890	Cyd operon protein YbgT
XDD1_1349	COG3790	cyd operon protein YbgE
XDD1_1350	COG0824	Thioesterase
XDD1_1351	COG0811	peptide transport
XDD1_1352	COG0848	biopolymer transport protein
XDD1_1353	COG3064	Membrane
XDD1_1354	COG0823	Involved in the tonB-independent uptake of proteins
XDD1_1355	COG2885	chlorophyll binding
XDD1_1356	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
XDD1_1359	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XDD1_1360	COG0588	phosphoglycerate mutase activity
XDD1_1362	COG1119	ATPase activity
XDD1_1365	COG0725	ABC transporter, periplasmic molybdate-binding protein
XDD1_1366	COG4149	molybdate abc transporter
XDD1_1367	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XDD1_1368	COG0561	phosphatase activity
XDD1_1370	COG2706	6-phosphogluconolactonase activity
XDD1_1377	COG0305	Participates in initiation and elongation during chromosome replication
XDD1_1384	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_1390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XDD1_1391	COG3423	Transcriptional regulator
XDD1_1406	COG1309	transcriptional regulator
XDD1_1408	COG0842	Transport permease protein
XDD1_1409	COG0842	Transport permease protein
XDD1_1410	COG1131	(ABC) transporter
XDD1_1412	COG1309	transcriptional regulator
XDD1_1414	COG0513	Belongs to the DEAD box helicase family
XDD1_1415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XDD1_1419	COG2261	transglycosylase associated protein
XDD1_1420	COG2897	thiosulfate sulfurtransferase activity
XDD1_1423	COG0488	(ABC) transporter
XDD1_1429	COG2824	Alkylphosphonate utilization operon protein PhnA
XDD1_1431	COG5006	permease, DMT superfamily
XDD1_1434	COG0488	(ABC) transporter
XDD1_1436	COG0303	'Molybdopterin
XDD1_1437	COG0477	Major facilitator Superfamily
XDD1_1438	COG0302	gtp cyclohydrolase
XDD1_1439	COG2311	Membrane
XDD1_1440	COG2949	membrane
XDD1_1441	COG0281	malic enzyme
XDD1_1442	COG0295	cytidine deaminase activity
XDD1_1443	COG1346	cytolysis
XDD1_1444	COG1380	Effector of murein hydrolase LrgA
XDD1_1445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_1445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_1447	COG0572	uridine kinase
XDD1_1448	COG0717	Belongs to the dCTP deaminase family
XDD1_1449	COG2982	Protein involved in outer membrane biogenesis
XDD1_1463	COG2826	transposase and inactivated derivatives, IS30 family
XDD1_1465	COG0670	Belongs to the BI1 family
XDD1_1466	COG0314	molybdopterin synthase activity
XDD1_1467	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XDD1_1469	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XDD1_1470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XDD1_1471	COG0556	nucleotide-excision repair
XDD1_1472	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XDD1_1473	COG2226	methyltransferase
XDD1_1474	COG0156	8-amino-7-oxononanoate synthase activity
XDD1_1475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XDD1_1491	COG3209	COG3209 Rhs family protein
XDD1_1494	COG3620	sequence-specific DNA binding
XDD1_1495	COG0358	DNA primase activity
XDD1_1496	COG4974	Belongs to the 'phage' integrase family
XDD1_1499	COG3335	DDE superfamily endonuclease
XDD1_1509	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_1509	COG1522	sequence-specific DNA binding
XDD1_1517	COG1253	flavin adenine dinucleotide binding
XDD1_1518	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
XDD1_1520	COG1454	alcohol dehydrogenase
XDD1_1521	COG0140	phosphoribosyl-ATP diphosphatase activity
XDD1_1521	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XDD1_1522	COG0107	imidazoleglycerol-phosphate synthase activity
XDD1_1523	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XDD1_1524	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XDD1_1525	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XDD1_1525	COG0131	Imidazoleglycerol-phosphate dehydratase
XDD1_1526	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XDD1_1526	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XDD1_1527	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XDD1_1527	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XDD1_1528	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XDD1_1530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_1531	COG0625	glutathione transferase activity
XDD1_1532	COG1686	Belongs to the peptidase S11 family
XDD1_1533	COG0814	amino acid
XDD1_1534	COG0671	phosphoesterase, PA-phosphatase related
XDD1_1535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
XDD1_1539	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XDD1_1540	COG4160	amino acid transport
XDD1_1541	COG4215	(ABC) transporter
XDD1_1542	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_1543	COG1126	abc transporter atp-binding protein
XDD1_1544	COG2431	L-lysine efflux transmembrane transporter activity
XDD1_1546	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_1547	COG1136	(ABC) transporter
XDD1_1547	COG0577	efflux transmembrane transporter activity
XDD1_1548	COG1278	Cold shock
XDD1_1549	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XDD1_1550	COG0542	response to heat
XDD1_1552	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XDD1_1553	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XDD1_1555	COG0492	ferredoxin-NADP+ reductase activity
XDD1_1557	COG1522	sequence-specific DNA binding
XDD1_1558	COG3107	peptidoglycan biosynthetic process
XDD1_1558	COG1674	ftsk spoiiie
XDD1_1559	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XDD1_1560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XDD1_1561	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XDD1_1565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
XDD1_1566	COG1882	Formate acetyltransferase
XDD1_1567	COG2116	formate transmembrane transporter activity
XDD1_1568	COG1944	ATP diphosphatase activity
XDD1_1569	COG0252	asparaginase activity
XDD1_1570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XDD1_1571	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XDD1_1572	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XDD1_1574	COG0539	negative regulation of cytoplasmic translation
XDD1_1576	COG0658	competence protein
XDD1_1576	COG2333	competence protein COMEC
XDD1_1577	COG1132	(ABC) transporter
XDD1_1578	COG1663	tetraacyldisaccharide 4'-kinase activity
XDD1_1579	COG2835	tetraacyldisaccharide 4'-kinase activity
XDD1_1580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XDD1_1581	COG1434	Gram-negative-bacterium-type cell wall biogenesis
XDD1_1582	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XDD1_1583	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
XDD1_1584	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
XDD1_1585	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
XDD1_1586	COG3700	Belongs to the class B bacterial acid phosphatase family
XDD1_1587	COG2989	Protein conserved in bacteria
XDD1_1588	COG3108	Peptidase M15
XDD1_1589	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XDD1_1590	COG1448	Aminotransferase
XDD1_1591	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XDD1_1592	COG0017	Asparaginyl-tRNA synthetase
XDD1_1593	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XDD1_1595	COG0308	aminopeptidase N
XDD1_1596	COG0167	dihydroorotate dehydrogenase activity
XDD1_1598	COG3217	Mosc domain protein beta barrel domain protein
XDD1_1598	COG0633	Ferredoxin
XDD1_1599	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XDD1_1599	COG0116	Belongs to the methyltransferase superfamily
XDD1_1600	COG0488	(ABC) transporter
XDD1_1601	COG2995	paraquat-inducible protein a
XDD1_1602	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XDD1_1602	COG3008	intermembrane lipid transfer
XDD1_1603	COG3009	Protein conserved in bacteria
XDD1_1604	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XDD1_1605	COG1067	ATP-dependent peptidase activity
XDD1_1606	COG3120	sequence-specific DNA binding
XDD1_1609	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
XDD1_1634	COG1289	transmembrane transporter activity
XDD1_1635	COG0210	DNA helicase
XDD1_1636	COG1832	CoA-binding protein
XDD1_1637	COG3785	DNA binding
XDD1_1638	COG1254	Belongs to the acylphosphatase family
XDD1_1639	COG2920	part of a sulfur-relay system
XDD1_1643	COG4104	PAAR repeat-containing protein
XDD1_1648	COG4626	Terminase
XDD1_1648	COG1802	Transcriptional regulator
XDD1_1649	COG3423	Transcriptional regulator
XDD1_1655	COG0183	Belongs to the thiolase family
XDD1_1656	COG0667	Aldo Keto reductase
XDD1_1662	COG1113	amino acid transport
XDD1_1670	COG0583	DNA-binding transcription factor activity
XDD1_1671	COG0697	spore germination
XDD1_1674	COG2197	response regulator
XDD1_1675	COG0322	excinuclease ABC activity
XDD1_1676	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XDD1_1678	COG0582	viral genome integration into host DNA
XDD1_1694	COG1802	Transcriptional regulator
XDD1_1694	COG4626	Terminase
XDD1_1695	COG3423	Transcriptional regulator
XDD1_1699	COG4682	membrane
XDD1_1707	COG3545	Serine hydrolase
XDD1_1709	COG1304	FMN binding
XDD1_1717	COG1560	Kdo2-lipid A biosynthetic process
XDD1_1719	COG0501	Belongs to the peptidase M48B family
XDD1_1723	COG2197	response regulator
XDD1_1725	COG2271	Major facilitator Superfamily
XDD1_1726	COG2226	methyltransferase
XDD1_1727	COG1971	Probably functions as a manganese efflux pump
XDD1_1728	COG4811	Protein of unknown function (DUF986)
XDD1_1729	COG3716	PTS system mannose fructose sorbose family IID component
XDD1_1730	COG3715	PTS system
XDD1_1731	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_1731	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_1732	COG1760	l-serine dehydratase
XDD1_1733	COG0494	nUDIX hydrolase
XDD1_1735	COG3140	Belongs to the UPF0181 family
XDD1_1742	COG1528	Iron-storage protein
XDD1_1743	COG2372	response to copper ion
XDD1_1744	COG1276	copper resistance
XDD1_1746	COG1956	GAF domain-containing protein
XDD1_1747	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
XDD1_1749	COG0501	Belongs to the peptidase M48B family
XDD1_1751	COG1988	membrane-bound metal-dependent
XDD1_1757	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XDD1_1758	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XDD1_1759	COG1121	(ABC) transporter
XDD1_1760	COG0803	Belongs to the bacterial solute-binding protein 9 family
XDD1_1772	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XDD1_1773	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XDD1_1774	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XDD1_1777	COG0072	phenylalanine-tRNA ligase activity
XDD1_1777	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_1778	COG0776	regulation of translation
XDD1_1779	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XDD1_1780	COG0463	Glycosyl transferase, family 2
XDD1_1781	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XDD1_1781	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_1782	COG0726	polysaccharide deacetylase
XDD1_1783	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XDD1_1785	COG2076	Multidrug Resistance protein
XDD1_1786	COG0791	NLP P60 protein
XDD1_1789	COG2826	transposase and inactivated derivatives, IS30 family
XDD1_1792	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_1796	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XDD1_1796	COG4221	oxidoreductase activity
XDD1_1796	COG3321	synthase
XDD1_1796	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_1808	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_1809	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XDD1_1810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_1811	COG4558	Periplasmic binding protein
XDD1_1812	COG3720	iron ion transport
XDD1_1814	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XDD1_1815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XDD1_1819	COG4974	Belongs to the 'phage' integrase family
XDD1_1820	COG0358	DNA primase activity
XDD1_1821	COG1476	TRANSCRIPTIONal
XDD1_1825	COG4974	Belongs to the 'phage' integrase family
XDD1_1826	COG0358	DNA primase activity
XDD1_1833	COG4974	Belongs to the 'phage' integrase family
XDD1_1834	COG0358	DNA primase activity
XDD1_1843	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XDD1_1843	COG0574	Belongs to the PEP-utilizing enzyme family
XDD1_1844	COG0628	permease
XDD1_1845	COG0247	lactate metabolic process
XDD1_1845	COG0277	FAD linked oxidase domain protein
XDD1_1846	COG2050	protein possibly involved in aromatic compounds catabolism
XDD1_1848	COG1388	LysM domain
XDD1_1848	COG1376	ErfK ybiS ycfS ynhG family protein
XDD1_1849	COG4238	major outer membrane lipoprotein
XDD1_1851	COG0534	Mate efflux family protein
XDD1_1852	COG0307	riboflavin synthase, alpha
XDD1_1853	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XDD1_1855	COG2814	Major facilitator Superfamily
XDD1_1856	COG0583	DNA-binding transcription factor activity
XDD1_1857	COG1609	Transcriptional regulator
XDD1_1858	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XDD1_1859	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XDD1_1860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XDD1_1861	COG0346	lactoylglutathione lyase activity
XDD1_1862	COG3313	Fe-S protein
XDD1_1864	COG3133	Outer membrane lipoprotein
XDD1_1865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XDD1_1866	COG0259	pyridoxamine-phosphate oxidase activity
XDD1_1867	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XDD1_1868	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XDD1_1872	COG4171	peptide transport system, permease
XDD1_1873	COG4168	peptide transport system, permease
XDD1_1874	COG4166	transmembrane transport
XDD1_1875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
XDD1_1876	COG1842	Phage shock protein A
XDD1_1878	COG1983	PspC domain protein
XDD1_1879	COG3106	COG3106 Predicted ATPase
XDD1_1902	COG3501	Rhs element vgr protein
XDD1_1903	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
XDD1_1904	COG0598	Magnesium transport protein CorA
XDD1_1905	COG0037	tRNA processing
XDD1_1910	COG2076	Multidrug Resistance protein
XDD1_1912	COG0583	DNA-binding transcription factor activity
XDD1_1913	COG2814	Major facilitator Superfamily
XDD1_1914	COG0542	response to heat
XDD1_1917	COG3335	DDE superfamily endonuclease
XDD1_1920	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_1924	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XDD1_1926	COG3152	Membrane
XDD1_1927	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_1928	COG3734	2-keto-3-deoxy-galactonokinase
XDD1_1929	COG0800	Aldolase
XDD1_1931	COG2271	Major facilitator Superfamily
XDD1_1936	COG2814	Major facilitator Superfamily
XDD1_1940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XDD1_1941	COG0589	response to stress
XDD1_1942	COG0589	response to stress
XDD1_1944	COG2356	endonuclease I
XDD1_1951	COG3335	DDE superfamily endonuclease
XDD1_1960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XDD1_1963	COG4264	IucA IucC family
XDD1_1964	COG0019	diaminopimelate decarboxylase activity
XDD1_1965	COG0477	Major facilitator Superfamily
XDD1_1966	COG4264	IucA IucC family
XDD1_1968	COG4264	IucA IucC family
XDD1_1969	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XDD1_1970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_1971	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_1972	COG1120	ATPase activity
XDD1_1974	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XDD1_1975	COG1294	oxidase, subunit
XDD1_1976	COG1271	oxidase subunit
XDD1_1979	COG1309	transcriptional regulator
XDD1_1982	COG0443	Heat shock 70 kDa protein
XDD1_1983	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XDD1_1986	COG0579	oxidoreductase
XDD1_1993	COG2249	NAD(P)H dehydrogenase (quinone) activity
XDD1_1994	COG2207	Transcriptional regulator
XDD1_1995	COG0012	GTP binding
XDD1_1996	COG0193	aminoacyl-tRNA hydrolase activity
XDD1_2000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XDD1_2001	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XDD1_2002	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XDD1_2003	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XDD1_2004	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XDD1_2005	COG2890	protein-(glutamine-N5) methyltransferase activity
XDD1_2006	COG2912	Transglutaminase-like superfamily
XDD1_2007	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XDD1_2008	COG0659	secondary active sulfate transmembrane transporter activity
XDD1_2009	COG0671	phosphoesterase, PA-phosphatase related
XDD1_2009	COG2453	phosphatase
XDD1_2010	COG2267	carboxylic ester hydrolase activity
XDD1_2011	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XDD1_2012	COG2378	regulation of single-species biofilm formation
XDD1_2018	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_2019	COG3381	protein complex oligomerization
XDD1_2026	COG0477	Major facilitator Superfamily
XDD1_2027	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XDD1_2028	COG3335	DDE superfamily endonuclease
XDD1_2049	COG3501	Rhs element vgr protein
XDD1_2054	COG0018	arginyl-trna synthetase
XDD1_2056	COG3142	Participates in the control of copper homeostasis
XDD1_2057	COG0500	methyltransferase
XDD1_2058	COG2226	methyltransferase
XDD1_2059	COG3788	relative of glutathione S-transferase, MAPEG superfamily
XDD1_2061	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XDD1_2062	COG0494	nUDIX hydrolase
XDD1_2063	COG0217	transcriptional regulatory protein
XDD1_2064	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XDD1_2065	COG0632	four-way junction helicase activity
XDD1_2066	COG2255	four-way junction helicase activity
XDD1_2069	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XDD1_2070	COG1121	(ABC) transporter
XDD1_2071	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
XDD1_2072	COG0739	heme binding
XDD1_2073	COG1560	Kdo2-lipid A biosynthetic process
XDD1_2074	COG0469	pyruvate kinase activity
XDD1_2075	COG1737	Transcriptional regulator
XDD1_2077	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XDD1_2078	COG2076	Multidrug Resistance protein
XDD1_2079	COG2076	Multidrug Resistance protein
XDD1_2080	COG0251	oxidation-reduction process
XDD1_2081	COG1199	ATP-dependent helicase activity
XDD1_2083	COG3065	identical protein binding
XDD1_2084	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_2085	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XDD1_2086	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XDD1_2087	COG2894	cell division
XDD1_2088	COG0850	regulation of cytokinetic process
XDD1_2089	COG3100	YcgL domain-containing protein
XDD1_2090	COG2951	lytic endotransglycosylase activity
XDD1_2091	COG0179	Fumarylacetoacetate (FAA) hydrolase
XDD1_2092	COG2983	Belongs to the UPF0260 family
XDD1_2096	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XDD1_2097	COG2911	Protein conserved in bacteria
XDD1_2099	COG3784	Protein of unknown function (DUF1318)
XDD1_2101	COG1643	Atp-dependent helicase
XDD1_2105	COG3121	Chaperone
XDD1_2106	COG3539	Fimbrial protein
XDD1_2107	COG0531	amino acid
XDD1_2110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XDD1_2111	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XDD1_2114	COG1136	(ABC) transporter
XDD1_2114	COG0577	efflux transmembrane transporter activity
XDD1_2116	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_2122	COG4974	Belongs to the 'phage' integrase family
XDD1_2128	COG3335	DDE superfamily endonuclease
XDD1_2129	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XDD1_2136	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XDD1_2140	COG2814	Major facilitator Superfamily
XDD1_2146	COG0477	Major facilitator Superfamily
XDD1_2149	COG0697	spore germination
XDD1_2151	COG4771	TonB-dependent receptor
XDD1_2160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
XDD1_2161	COG1902	pentaerythritol trinitrate reductase activity
XDD1_2162	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XDD1_2163	COG3118	belongs to the thioredoxin family
XDD1_2165	COG2207	Transcriptional regulator
XDD1_2165	COG1917	Cupin 2, conserved barrel domain protein
XDD1_2167	COG0688	phosphatidylethanolamine metabolic process
XDD1_2169	COG1132	(ABC) transporter
XDD1_2170	COG4221	oxidoreductase activity
XDD1_2173	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XDD1_2175	COG3335	DDE superfamily endonuclease
XDD1_2177	COG2814	Major facilitator Superfamily
XDD1_2180	COG0114	fumarate hydratase activity
XDD1_2182	COG5339	Protein conserved in bacteria
XDD1_2183	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XDD1_2184	COG0385	Bile acid
XDD1_2185	COG0673	inositol 2-dehydrogenase activity
XDD1_2187	COG4657	Part of a membrane complex involved in electron transport
XDD1_2189	COG4656	Part of a membrane complex involved in electron transport
XDD1_2191	COG4659	FMN binding
XDD1_2194	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XDD1_2195	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
XDD1_2197	COG0023	Translation Initiation Factor
XDD1_2198	COG0284	orotidine-5'-phosphate decarboxylase activity
XDD1_2199	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XDD1_2200	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
XDD1_2203	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
XDD1_2206	COG0583	DNA-binding transcription factor activity
XDD1_2207	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_2209	COG0616	signal peptide processing
XDD1_2211	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_2213	COG0009	L-threonylcarbamoyladenylate synthase
XDD1_2217	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XDD1_2219	COG0133	tryptophan synthase activity
XDD1_2220	COG0159	tryptophan synthase activity
XDD1_2221	COG3047	cAMP biosynthetic process
XDD1_2224	COG2917	probably involved in intracellular septation
XDD1_2225	COG1607	acyl-coa hydrolase
XDD1_2226	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XDD1_2228	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XDD1_2229	COG3099	Belongs to the UPF0263 family
XDD1_2231	COG0444	Belongs to the ABC transporter superfamily
XDD1_2232	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XDD1_2236	COG1454	alcohol dehydrogenase
XDD1_2236	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_2237	COG1435	thymidine kinase activity
XDD1_2241	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XDD1_2242	COG3012	SEC-C Motif Domain Protein
XDD1_2243	COG0788	formyltetrahydrofolate deformylase activity
XDD1_2246	COG0708	Exodeoxyribonuclease III
XDD1_2247	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XDD1_2248	COG0709	Synthesizes selenophosphate from selenide and ATP
XDD1_2249	COG0778	Nitroreductase
XDD1_2250	COG0616	signal peptide processing
XDD1_2251	COG0252	asparaginase activity
XDD1_2252	COG3139	Protein of unknown function (DUF1315)
XDD1_2256	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XDD1_2257	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_2258	COG2186	Transcriptional regulator
XDD1_2259	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XDD1_2260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XDD1_2268	COG2814	Major facilitator Superfamily
XDD1_2274	COG0531	amino acid
XDD1_2275	COG1982	Orn Lys Arg decarboxylase major
XDD1_2284	COG0076	glutamate decarboxylase activity
XDD1_2289	COG0076	glutamate decarboxylase activity
XDD1_2294	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XDD1_2296	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XDD1_2296	COG0506	proline dehydrogenase activity
XDD1_2296	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XDD1_2298	COG1191	sigma factor activity
XDD1_2304	COG3335	DDE superfamily endonuclease
XDD1_2307	COG3077	Addiction module antitoxin, RelB DinJ family
XDD1_2308	COG1677	Flagellar hook-basal body complex protein FliE
XDD1_2310	COG1766	The M ring may be actively involved in energy transduction
XDD1_2311	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XDD1_2312	COG1317	bacterial-type flagellum organization
XDD1_2313	COG1157	protein secretion by the type III secretion system
XDD1_2314	COG2882	bacterial-type flagellum organization
XDD1_2317	COG1580	Controls the rotational direction of flagella during chemotaxis
XDD1_2322	COG1987	bacterial-type flagellum assembly
XDD1_2324	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_2328	COG3311	Transcriptional regulator
XDD1_2329	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XDD1_2330	COG1256	bacterial-type flagellum assembly
XDD1_2332	COG1706	bacterial-type flagellum-dependent cell motility
XDD1_2333	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XDD1_2334	COG4786	Flagellar basal body rod
XDD1_2336	COG1749	Flagellar hook protein flgE
XDD1_2337	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XDD1_2338	COG1558	bacterial-type flagellum-dependent cell motility
XDD1_2339	COG1815	bacterial-type flagellum-dependent cell motility
XDD1_2343	COG3335	DDE superfamily endonuclease
XDD1_2344	COG3539	Fimbrial protein
XDD1_2346	COG3121	Chaperone
XDD1_2353	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XDD1_2354	COG1115	amino acid carrier protein
XDD1_2359	COG3501	Rhs element vgr protein
XDD1_2367	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
XDD1_2368	COG0745	RESPONSE REGULATOR receiver
XDD1_2369	COG2201	protein-glutamate methylesterase activity
XDD1_2370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XDD1_2371	COG0840	transmembrane signaling receptor activity
XDD1_2372	COG0840	transmembrane signaling receptor activity
XDD1_2373	COG0835	chemotaxis
XDD1_2374	COG0643	Histidine kinase
XDD1_2374	COG2198	Histidine kinase
XDD1_2375	COG1360	Flagellar Motor Protein
XDD1_2380	COG1285	pathogenesis
XDD1_2381	COG1278	Cold shock
XDD1_2384	COG0418	dihydroorotase activity
XDD1_2392	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XDD1_2393	COG0519	Catalyzes the synthesis of GMP from XMP
XDD1_2393	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XDD1_2394	COG0516	GMP reductase activity
XDD1_2394	COG0517	IMP dehydrogenase activity
XDD1_2395	COG1570	exodeoxyribonuclease VII activity
XDD1_2401	COG1770	oligopeptidase
XDD1_2405	COG0281	malic enzyme
XDD1_2405	COG0280	phosphate acetyltransferase
XDD1_2408	COG2197	response regulator
XDD1_2409	COG1393	Belongs to the ArsC family
XDD1_2410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XDD1_2411	COG1876	peptidase activity
XDD1_2412	COG1444	tRNA N-acetyltransferase activity
XDD1_2413	COG2707	UPF0756 membrane protein
XDD1_2414	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XDD1_2415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
XDD1_2416	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XDD1_2417	COG2716	regulation of RNA biosynthetic process
XDD1_2420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XDD1_2421	COG0628	permease
XDD1_2422	COG4783	chaperone-mediated protein folding
XDD1_2423	COG1393	Belongs to the ArsC family
XDD1_2424	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XDD1_2426	COG2233	PERMEase
XDD1_2427	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XDD1_2428	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XDD1_2429	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XDD1_2430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XDD1_2431	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XDD1_2432	COG0248	Ppx GppA phosphatase
XDD1_2434	COG2239	Acts as a magnesium transporter
XDD1_2438	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_2441	COG1121	(ABC) transporter
XDD1_2442	COG3842	ATPase activity
XDD1_2446	COG3220	belongs to the UPF0276 family
XDD1_2454	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XDD1_2455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_2456	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_2457	COG2205	protein histidine kinase activity
XDD1_2458	COG0745	RESPONSE REGULATOR receiver
XDD1_2459	COG2814	Major facilitator Superfamily
XDD1_2460	COG3422	double-strand break repair
XDD1_2462	COG1830	Aldolase
XDD1_2463	COG0351	phosphomethylpyrimidine kinase
XDD1_2464	COG1278	Cold shock
XDD1_2467	COG2207	Transcriptional regulator
XDD1_2467	COG3708	Transcriptional regulator
XDD1_2468	COG3023	N-Acetylmuramoyl-L-alanine amidase
XDD1_2469	COG1115	amino acid carrier protein
XDD1_2473	COG0538	isocitrate dehydrogenase activity
XDD1_2474	COG1187	pseudouridine synthase activity
XDD1_2476	COG0482	sulfurtransferase activity
XDD1_2477	COG2915	High frequency lysogenization protein hflD homolog
XDD1_2478	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XDD1_2479	COG3335	DDE superfamily endonuclease
XDD1_2480	COG0745	RESPONSE REGULATOR receiver
XDD1_2482	COG2850	peptidyl-arginine hydroxylation
XDD1_2484	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XDD1_2485	COG4591	ABC-type transport system involved in lipoprotein release permease component
XDD1_2486	COG1136	(ABC) transporter
XDD1_2487	COG4591	ABC-type transport system involved in lipoprotein release permease component
XDD1_2488	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XDD1_2491	COG1252	NADH dehydrogenase
XDD1_2492	COG1472	Belongs to the glycosyl hydrolase 3 family
XDD1_2494	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
XDD1_2495	COG0537	adenosine 5'-monophosphoramidase activity
XDD1_2496	COG0084	hydrolase, TatD family'
XDD1_2497	COG0470	DNA polymerase III
XDD1_2498	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XDD1_2499	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XDD1_2500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XDD1_2501	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XDD1_2502	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XDD1_2503	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_2504	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XDD1_2505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XDD1_2506	COG0416	fatty acid biosynthetic process
XDD1_2507	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XDD1_2508	COG1399	metal-binding, possibly nucleic acid-binding protein
XDD1_2509	COG0424	maF-like protein
XDD1_2510	COG0564	pseudouridine synthase activity
XDD1_2511	COG1530	ribonuclease E activity
XDD1_2512	COG0702	epimerase
XDD1_2513	COG2926	Belongs to the UPF0265 family
XDD1_2514	COG2925	Exonuclease
XDD1_2515	COG0277	FAD linked oxidase domain protein
XDD1_2516	COG0531	amino acid
XDD1_2517	COG4771	TonB-dependent receptor
XDD1_2518	COG3842	ATPase activity
XDD1_2519	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XDD1_2521	COG0833	amino acid
XDD1_2522	COG0583	DNA-binding transcription factor activity
XDD1_2524	COG2855	membrane
XDD1_2525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
XDD1_2526	COG1105	Belongs to the carbohydrate kinase PfkB family
XDD1_2527	COG2816	NAD+ diphosphatase activity
XDD1_2529	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XDD1_2533	COG0671	phosphoesterase, PA-phosphatase related
XDD1_2535	COG0791	NLP P60 protein
XDD1_2537	COG2814	Major facilitator Superfamily
XDD1_2538	COG1187	pseudouridine synthase activity
XDD1_2539	COG1061	Type III restriction enzyme res subunit
XDD1_2540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XDD1_2541	COG3081	Nucleoid-associated protein
XDD1_2542	COG3082	Protein of unknown function (DUF1414)
XDD1_2546	COG3335	DDE superfamily endonuclease
XDD1_2551	COG3397	chitin binding
XDD1_2552	COG0346	lactoylglutathione lyase activity
XDD1_2555	COG3023	N-Acetylmuramoyl-L-alanine amidase
XDD1_2557	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XDD1_2558	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XDD1_2560	COG2205	protein histidine kinase activity
XDD1_2560	COG0784	Response regulator, receiver
XDD1_2561	COG2197	response regulator
XDD1_2562	COG2198	Histidine kinase
XDD1_2562	COG0642	Histidine kinase
XDD1_2564	COG0814	amino acid
XDD1_2567	COG1441	menaquinone biosynthetic process
XDD1_2568	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XDD1_2569	COG0596	Alpha beta hydrolase
XDD1_2570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
XDD1_2571	COG1169	isochorismate synthase
XDD1_2572	COG0457	Tetratricopeptide repeat
XDD1_2573	COG0726	polysaccharide deacetylase
XDD1_2573	COG1649	PFAM Uncharacterised BCR, COG1649
XDD1_2574	COG1215	transferase activity, transferring glycosyl groups
XDD1_2577	COG2199	diguanylate cyclase activity
XDD1_2578	COG2885	chlorophyll binding
XDD1_2579	COG2200	EAL domain
XDD1_2582	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
XDD1_2583	COG1007	ATP synthesis coupled electron transport
XDD1_2584	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_2585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XDD1_2586	COG0713	ATP synthesis coupled electron transport
XDD1_2587	COG0839	Belongs to the complex I subunit 6 family
XDD1_2588	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_2590	COG1034	ATP synthesis coupled electron transport
XDD1_2592	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XDD1_2593	COG0649	NAD binding
XDD1_2593	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_2594	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_2595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XDD1_2596	COG0583	DNA-binding transcription factor activity
XDD1_2597	COG0436	Aminotransferase
XDD1_2598	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XDD1_2599	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
XDD1_2600	COG0471	metal ion transport
XDD1_2600	COG0490	domain, Protein
XDD1_2601	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XDD1_2603	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XDD1_2604	COG0857	belongs to the CobB CobQ family
XDD1_2604	COG0280	phosphate acetyltransferase
XDD1_2608	COG3335	DDE superfamily endonuclease
XDD1_2615	COG3335	DDE superfamily endonuclease
XDD1_2617	COG0582	viral genome integration into host DNA
XDD1_2619	COG2067	long-chain fatty acid transport protein
XDD1_2620	COG3691	Protein conserved in bacteria
XDD1_2621	COG0183	Belongs to the thiolase family
XDD1_2622	COG1024	Enoyl-CoA hydratase
XDD1_2622	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_2623	COG2062	phosphohistidine phosphatase, SixA
XDD1_2624	COG2840	Smr protein MutS2
XDD1_2625	COG1228	amidohydrolase
XDD1_2626	COG0010	Belongs to the arginase family
XDD1_2628	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XDD1_2629	COG2986	histidine ammonia-lyase
XDD1_2631	COG2890	protein-(glutamine-N5) methyltransferase activity
XDD1_2633	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XDD1_2634	COG0730	response to heat
XDD1_2635	COG3101	peptidyl-lysine hydroxylation
XDD1_2639	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
XDD1_2639	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XDD1_2640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XDD1_2646	COG0642	Histidine kinase
XDD1_2648	COG2207	Transcriptional regulator
XDD1_2649	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_2650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XDD1_2651	COG0101	tRNA pseudouridine synthase activity
XDD1_2652	COG0586	Pfam SNARE associated Golgi protein
XDD1_2653	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XDD1_2654	COG0285	dihydrofolate synthase activity
XDD1_2655	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
XDD1_2656	COG1286	toxin biosynthetic process
XDD1_2657	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
XDD1_2658	COG0163	prenyltransferase activity
XDD1_2659	COG1090	epimerase
XDD1_2660	COG0625	glutathione transferase activity
XDD1_2661	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
XDD1_2670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XDD1_2671	COG3138	arginine N-succinyltransferase
XDD1_2672	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_2673	COG3724	N-succinylarginine dihydrolase activity
XDD1_2674	COG2988	succinylglutamate desuccinylase activity
XDD1_2675	COG1113	amino acid transport
XDD1_2682	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_2693	COG0859	PFAM glycosyl transferase family 9
XDD1_2694	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
XDD1_2696	COG0235	Class ii aldolase
XDD1_2698	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XDD1_2699	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_2700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XDD1_2701	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XDD1_2702	COG3115	cell septum assembly
XDD1_2704	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XDD1_2705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_2707	COG2190	(PTS) system
XDD1_2708	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_2720	COG1960	acyl-CoA dehydrogenase activity
XDD1_2723	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XDD1_2726	COG1176	ABC-type spermidine putrescine transport system, permease component I
XDD1_2727	COG3842	ATPase activity
XDD1_2728	COG0584	glycerophosphoryl diester phosphodiesterase
XDD1_2733	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XDD1_2734	COG4208	sulfate ABC transporter
XDD1_2735	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XDD1_2739	COG0456	acetyltransferase
XDD1_2756	COG4626	Terminase
XDD1_2756	COG1802	Transcriptional regulator
XDD1_2758	COG3423	Transcriptional regulator
XDD1_2759	COG0408	coproporphyrinogen oxidase activity
XDD1_2766	COG1160	GTP binding
XDD1_2767	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_2768	COG2976	Protein conserved in bacteria
XDD1_2769	COG0124	histidyl-tRNA synthetase
XDD1_2770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XDD1_2773	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XDD1_2774	COG0105	UTP biosynthetic process
XDD1_2775	COG3655	Transcriptional regulator
XDD1_2777	COG4953	penicillin-binding protein 1C
XDD1_2778	COG2373	Large extracellular alpha-helical protein
XDD1_2780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XDD1_2781	COG2975	iron-sulfur cluster assembly
XDD1_2782	COG0633	Ferredoxin
XDD1_2783	COG0443	Heat shock 70 kDa protein
XDD1_2784	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XDD1_2785	COG0316	Belongs to the HesB IscA family
XDD1_2786	COG0822	iron-sulfur transferase activity
XDD1_2787	COG1104	cysteine desulfurase activity
XDD1_2788	COG1959	2 iron, 2 sulfur cluster binding
XDD1_2789	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
XDD1_2791	COG2814	Major facilitator Superfamily
XDD1_2792	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XDD1_2793	COG1017	nitric oxide dioxygenase activity
XDD1_2793	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XDD1_2794	COG0347	Belongs to the P(II) protein family
XDD1_2795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XDD1_2795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XDD1_2796	COG2204	response regulator
XDD1_2797	COG3170	Tfp pilus assembly protein FimV
XDD1_2798	COG2205	protein histidine kinase activity
XDD1_2799	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XDD1_2799	COG0047	phosphoribosylformylglycinamidine synthase activity
XDD1_2800	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
XDD1_2801	COG0590	tRNA wobble adenosine to inosine editing
XDD1_2802	COG1418	mRNA catabolic process
XDD1_2803	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XDD1_2805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XDD1_2806	COG0736	holo-[acyl-carrier-protein] synthase activity
XDD1_2807	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XDD1_2808	COG1381	Involved in DNA repair and RecF pathway recombination
XDD1_2809	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XDD1_2810	COG0571	ribonuclease III activity
XDD1_2811	COG0681	Belongs to the peptidase S26 family
XDD1_2812	COG0481	GTPase activity
XDD1_2813	COG3086	response to oxidative stress
XDD1_2816	COG1595	DNA-templated transcription, initiation
XDD1_2817	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
XDD1_2818	COG0513	Belongs to the DEAD box helicase family
XDD1_2820	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
XDD1_2821	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XDD1_2822	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XDD1_2823	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XDD1_2824	COG0497	DNA recombination
XDD1_2825	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_2826	COG2914	Belongs to the UPF0125 (RnfH) family
XDD1_2827	COG2867	negative regulation of translational initiation
XDD1_2828	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XDD1_2858	COG4695	Portal protein
XDD1_2870	COG4974	Belongs to the 'phage' integrase family
XDD1_2871	COG3335	DDE superfamily endonuclease
XDD1_2889	COG3038	cytochrome b561
XDD1_2890	COG2353	YceI-like domain
XDD1_2894	COG1309	transcriptional regulator
XDD1_2895	COG2814	Major facilitator Superfamily
XDD1_2897	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XDD1_2899	COG2841	Protein conserved in bacteria
XDD1_2912	COG5301	cellulose 1,4-beta-cellobiosidase activity
XDD1_2931	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XDD1_2932	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_2933	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_2937	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XDD1_2938	COG0346	lactoylglutathione lyase activity
XDD1_2942	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_2942	COG1522	sequence-specific DNA binding
XDD1_2948	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XDD1_2949	COG0732	type I restriction modification DNA specificity domain
XDD1_2951	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XDD1_2952	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XDD1_2953	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XDD1_2954	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XDD1_2955	COG4974	Belongs to the 'phage' integrase family
XDD1_2956	COG0716	FMN binding
XDD1_2958	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XDD1_2959	COG0354	folic acid binding
XDD1_2961	COG3135	benzoate transporter
XDD1_2965	COG3335	DDE superfamily endonuclease
XDD1_2967	COG2814	Major facilitator Superfamily
XDD1_2969	COG2192	nodulation
XDD1_2972	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XDD1_2972	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XDD1_2973	COG0509	glycine decarboxylation via glycine cleavage system
XDD1_2974	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XDD1_2975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XDD1_2976	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XDD1_2977	COG0006	proline dipeptidase activity
XDD1_2978	COG3079	Belongs to the UPF0149 family
XDD1_2981	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XDD1_2982	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_2984	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XDD1_2985	COG0583	DNA-binding transcription factor activity
XDD1_2988	COG1279	arginine transmembrane transporter activity
XDD1_2989	COG0668	transmembrane transport
XDD1_2990	COG3112	Uncharacterised protein family (UPF0231)
XDD1_2994	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XDD1_2995	COG0508	dehydrogenase complex catalyzes the overall conversion of
XDD1_2996	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XDD1_2997	COG2186	Transcriptional regulator
XDD1_3001	COG3725	Membrane protein required for beta-lactamase induction
XDD1_3002	COG3023	N-Acetylmuramoyl-L-alanine amidase
XDD1_3003	COG4969	Belongs to the N-Me-Phe pilin family
XDD1_3004	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XDD1_3006	COG0237	dephospho-CoA kinase activity
XDD1_3007	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
XDD1_3008	COG0494	nUDIX hydrolase
XDD1_3009	COG0653	protein targeting
XDD1_3012	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XDD1_3014	COG0849	cell division
XDD1_3015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XDD1_3016	COG1181	Belongs to the D-alanine--D-alanine ligase family
XDD1_3017	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XDD1_3018	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XDD1_3019	COG0772	Belongs to the SEDS family
XDD1_3020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XDD1_3021	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XDD1_3022	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XDD1_3023	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XDD1_3024	COG0768	penicillin binding
XDD1_3025	COG3116	cell division
XDD1_3026	COG0275	rRNA processing
XDD1_3027	COG2001	Belongs to the MraZ family
XDD1_3028	COG1609	Transcriptional regulator
XDD1_3030	COG0028	Belongs to the TPP enzyme family
XDD1_3031	COG1022	Amp-dependent synthetase and ligase
XDD1_3034	COG0473	3-isopropylmalate dehydrogenase activity
XDD1_3036	COG3066	DNA modification
XDD1_3038	COG0242	peptide deformylase activity
XDD1_3039	COG0626	cystathionine gamma-synthase activity
XDD1_3051	COG3842	ATPase activity
XDD1_3052	COG0534	Mate efflux family protein
XDD1_3057	COG0814	amino acid
XDD1_3058	COG0582	viral genome integration into host DNA
XDD1_3059	COG0523	cobalamin synthesis protein
XDD1_3060	COG2879	small protein
XDD1_3061	COG1966	Carbon starvation protein
XDD1_3062	COG2194	sulfuric ester hydrolase activity
XDD1_3065	COG1840	ABC-type Fe3 transport system, periplasmic component
XDD1_3067	COG2271	Major facilitator Superfamily
XDD1_3070	COG1335	isochorismatase
XDD1_3071	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XDD1_3072	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XDD1_3076	COG3335	DDE superfamily endonuclease
XDD1_3090	COG4626	Terminase
XDD1_3090	COG1802	Transcriptional regulator
XDD1_3094	COG3423	Transcriptional regulator
XDD1_3099	COG0288	reversible hydration of carbon dioxide
XDD1_3100	COG1131	(ABC) transporter
XDD1_3101	COG0842	Transport permease protein
XDD1_3102	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XDD1_3103	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XDD1_3104	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XDD1_3106	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XDD1_3107	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XDD1_3108	COG1489	DNA binding
XDD1_3109	COG1643	Atp-dependent helicase
XDD1_3110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XDD1_3118	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_3119	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XDD1_3120	COG0316	Belongs to the HesB IscA family
XDD1_3121	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XDD1_3122	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XDD1_3123	COG0232	Belongs to the dGTPase family. Type 2 subfamily
XDD1_3124	COG2205	protein histidine kinase activity
XDD1_3124	COG3437	response regulator, receiver
XDD1_3124	COG3850	Histidine kinase
XDD1_3124	COG4999	Histidine kinase
XDD1_3125	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XDD1_3126	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XDD1_3127	COG3956	TIGRFAM MazG family protein
XDD1_3128	COG0504	CTP synthase activity
XDD1_3129	COG0148	phosphopyruvate hydratase activity
XDD1_3132	COG0471	metal ion transport
XDD1_3134	COG1301	dicarboxylic acid transport
XDD1_3137	COG3091	SprT-like family
XDD1_3138	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XDD1_3139	COG1166	arginine decarboxylase activity
XDD1_3140	COG0010	Belongs to the arginase family
XDD1_3145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XDD1_3146	COG1085	galactose-1-phosphate uridylyltransferase
XDD1_3147	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
XDD1_3150	COG3335	DDE superfamily endonuclease
XDD1_3152	COG0024	Methionine aminopeptidase
XDD1_3156	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XDD1_3159	COG4942	peptidase
XDD1_3159	COG1388	LysM domain
XDD1_3160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XDD1_3161	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XDD1_3162	COG0585	pseudouridine synthase activity
XDD1_3163	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XDD1_3164	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XDD1_3165	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XDD1_3168	COG2895	sulfate adenylyltransferase (ATP) activity
XDD1_3169	COG0175	sulfate reduction
XDD1_3170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XDD1_3170	COG1648	precorrin-2 dehydrogenase activity
XDD1_3171	COG0175	sulfate reduction
XDD1_3172	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XDD1_3173	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XDD1_3175	COG0720	synthase
XDD1_3176	COG0602	queuosine metabolic process
XDD1_3178	COG3021	interspecies interaction between organisms
XDD1_3184	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
XDD1_3186	COG1739	Uncharacterized protein family UPF0029
XDD1_3187	COG0006	proline dipeptidase activity
XDD1_3188	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_3188	COG1024	Enoyl-CoA hydratase
XDD1_3189	COG0183	Belongs to the thiolase family
XDD1_3191	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
XDD1_3194	COG0805	protein transport
XDD1_3195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XDD1_3196	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XDD1_3197	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XDD1_3198	COG3165	ubiquinone biosynthetic process from chorismate
XDD1_3199	COG2226	methyltransferase
XDD1_3200	COG1322	Protein conserved in bacteria
XDD1_3201	COG0586	Pfam SNARE associated Golgi protein
XDD1_3203	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
XDD1_3204	COG2610	gluconate transmembrane transporter activity
XDD1_3205	COG2610	gluconate transmembrane transporter activity
XDD1_3206	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_3207	COG1349	DNA-binding transcription factor activity
XDD1_3208	COG3622	Belongs to the hyi family
XDD1_3209	COG3395	kinase activity
XDD1_3210	COG2084	Dehydrogenase
XDD1_3214	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XDD1_3215	COG0583	DNA-binding transcription factor activity
XDD1_3216	COG0697	spore germination
XDD1_3217	COG0025	NhaP-type Na H and K H
XDD1_3218	COG2252	PERMEase
XDD1_3227	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XDD1_3230	COG1448	Aminotransferase
XDD1_3231	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XDD1_3232	COG0305	Participates in initiation and elongation during chromosome replication
XDD1_3233	COG3423	Transcriptional regulator
XDD1_3254	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XDD1_3256	COG0735	belongs to the Fur family
XDD1_3258	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XDD1_3259	COG2937	Belongs to the GPAT DAPAT family
XDD1_3260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XDD1_3261	COG3161	chorismate lyase activity
XDD1_3262	COG0166	Belongs to the GPI family
XDD1_3263	COG0527	aspartate kinase activity
XDD1_3265	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
XDD1_3268	COG0800	Aldolase
XDD1_3269	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XDD1_3270	COG2224	Isocitrate lyase
XDD1_3271	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XDD1_3272	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XDD1_3277	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XDD1_3278	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XDD1_3280	COG1464	Belongs to the NlpA lipoprotein family
XDD1_3283	COG1720	tRNA m6t6A37 methyltransferase activity
XDD1_3284	COG0442	prolyl-tRNA aminoacylation
XDD1_3285	COG3015	lipoprotein NlpE involved in copper resistance
XDD1_3286	COG4568	rho-dependent transcription termination
XDD1_3288	COG0037	tRNA processing
XDD1_3290	COG0825	malonyl-CoA metabolic process
XDD1_3292	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XDD1_3293	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_3294	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_3295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XDD1_3296	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XDD1_3298	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XDD1_3299	COG0750	zinc metalloprotease
XDD1_3300	COG0575	Belongs to the CDS family
XDD1_3301	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XDD1_3302	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XDD1_3303	COG0233	cytoplasmic translational termination
XDD1_3304	COG0528	UMP kinase activity
XDD1_3305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XDD1_3306	COG0052	Belongs to the universal ribosomal protein uS2 family
XDD1_3307	COG0024	Methionine aminopeptidase
XDD1_3308	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XDD1_3314	COG0564	pseudouridine synthase activity
XDD1_3315	COG3098	single-species biofilm formation
XDD1_3320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XDD1_3320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XDD1_3323	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XDD1_3333	COG2890	protein-(glutamine-N5) methyltransferase activity
XDD1_3334	COG0156	8-amino-7-oxononanoate synthase activity
XDD1_3339	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XDD1_3339	COG0512	Glutamine amidotransferase of anthranilate synthase
XDD1_3341	COG0477	Major facilitator Superfamily
XDD1_3344	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_3345	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_3347	COG2363	Small membrane protein
XDD1_3348	COG0583	DNA-binding transcription factor activity
XDD1_3350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XDD1_3355	COG2166	iron-sulfur cluster assembly
XDD1_3356	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XDD1_3357	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
XDD1_3358	COG0860	N-Acetylmuramoyl-L-alanine amidase
XDD1_3359	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XDD1_3359	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
XDD1_3360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XDD1_3361	COG1074	ATP-dependent DNA helicase activity
XDD1_3363	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XDD1_3366	COG4795	General secretion pathway protein
XDD1_3367	COG2165	general secretion pathway protein
XDD1_3371	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XDD1_3372	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XDD1_3373	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
XDD1_3374	COG0494	nUDIX hydrolase
XDD1_3375	COG4143	(ABC) transporter
XDD1_3376	COG1178	ABC-type Fe3 transport system permease component
XDD1_3377	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
XDD1_3381	COG0417	DNA replication proofreading
XDD1_3382	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XDD1_3383	COG0564	pseudouridine synthase activity
XDD1_3384	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XDD1_3386	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XDD1_3387	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XDD1_3388	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XDD1_3389	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XDD1_3390	COG2967	ApaG domain
XDD1_3391	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XDD1_3393	COG2132	Multicopper oxidase
XDD1_3394	COG0204	Acyl-transferase
XDD1_3396	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XDD1_3397	COG0187	DNA topoisomerase II activity
XDD1_3398	COG3150	esterase
XDD1_3399	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XDD1_3400	COG0494	nUDIX hydrolase
XDD1_3401	COG1538	Outer membrane efflux protein
XDD1_3402	COG5463	Belongs to the UPF0441 family
XDD1_3403	COG0754	glutathionylspermidine amidase activity
XDD1_3404	COG3384	dioxygenase
XDD1_3405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XDD1_3407	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
XDD1_3407	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
XDD1_3408	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XDD1_3409	COG3025	triphosphatase activity
XDD1_3410	COG4991	sh3 domain protein
XDD1_3411	COG0617	tRNA 3'-terminal CCA addition
XDD1_3412	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XDD1_3413	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XDD1_3414	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XDD1_3416	COG0358	DNA primase activity
XDD1_3417	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XDD1_3420	COG1598	PFAM Uncharacterised protein family UPF0150
XDD1_3445	COG4695	Portal protein
XDD1_3457	COG4974	Belongs to the 'phage' integrase family
XDD1_3463	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XDD1_3466	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XDD1_3472	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XDD1_3474	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_3479	COG2990	Protein conserved in bacteria
XDD1_3481	COG1902	pentaerythritol trinitrate reductase activity
XDD1_3481	COG0446	pyridine nucleotide-disulphide oxidoreductase
XDD1_3482	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
XDD1_3483	COG0586	Pfam SNARE associated Golgi protein
XDD1_3484	COG4575	ribosome binding
XDD1_3485	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
XDD1_3487	COG2259	Doxx family
XDD1_3488	COG0583	DNA-binding transcription factor activity
XDD1_3489	COG1741	Belongs to the pirin family
XDD1_3490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XDD1_3492	COG0792	nuclease activity
XDD1_3493	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XDD1_3494	COG2823	Periplasmic or secreted lipoprotein
XDD1_3501	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XDD1_3502	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
XDD1_3503	COG0784	Response regulator, receiver
XDD1_3503	COG5002	protein histidine kinase activity
XDD1_3503	COG2198	Histidine kinase
XDD1_3504	COG0069	glutamate synthase activity
XDD1_3504	COG0067	glutamate synthase
XDD1_3504	COG0070	glutamate synthase
XDD1_3505	COG0493	'glutamate synthase
XDD1_3507	COG2969	positive regulation of protein catabolic process
XDD1_3508	COG0625	glutathione transferase activity
XDD1_3509	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XDD1_3510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XDD1_3511	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XDD1_3512	COG3105	Protein conserved in bacteria
XDD1_3513	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XDD1_3514	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XDD1_3515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XDD1_3516	COG5007	Belongs to the BolA IbaG family
XDD1_3518	COG2854	intermembrane phospholipid transfer
XDD1_3519	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XDD1_3520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XDD1_3521	COG1127	ABC transporter
XDD1_3522	COG0530	calcium, potassium:sodium antiporter activity
XDD1_3523	COG0517	IMP dehydrogenase activity
XDD1_3523	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
XDD1_3524	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XDD1_3525	COG3117	lipopolysaccharide transmembrane transporter activity
XDD1_3526	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XDD1_3527	COG1137	ATPase activity
XDD1_3528	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XDD1_3530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_3531	COG1660	Displays ATPase and GTPase activities
XDD1_3532	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XDD1_3535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XDD1_3538	COG0312	modulator of DNA gyrase
XDD1_3539	COG3028	Belongs to the UPF0307 family
XDD1_3540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XDD1_3542	COG0789	Transcriptional regulator
XDD1_3545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XDD1_3546	COG0312	modulator of DNA gyrase
XDD1_3547	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XDD1_3548	COG3164	Protein of unknown function
XDD1_3549	COG1530	ribonuclease E activity
XDD1_3550	COG0424	maF-like protein
XDD1_3551	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XDD1_3552	COG1792	Involved in formation and maintenance of cell shape
XDD1_3553	COG1077	Cell shape determining protein MreB Mrl
XDD1_3555	COG0604	alcohol dehydrogenase
XDD1_3556	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XDD1_3557	COG0511	ligase activity, forming carbon-carbon bonds
XDD1_3558	COG0439	Biotin carboxylase
XDD1_3559	COG3924	membrane
XDD1_3560	COG4145	pantothenate transmembrane transporter activity
XDD1_3561	COG2264	protein methyltransferase activity
XDD1_3562	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XDD1_3563	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XDD1_3573	COG1396	sequence-specific DNA binding
XDD1_3574	COG1929	Belongs to the glycerate kinase type-1 family
XDD1_3576	COG2177	Part of the ABC transporter FtsEX involved in
XDD1_3577	COG2884	Cell division ATP-binding protein ftsE
XDD1_3578	COG0552	protein localization to endoplasmic reticulum
XDD1_3578	COG0552	protein localization to endoplasmic reticulum
XDD1_3579	COG0742	ribosomal rna small subunit methyltransferase
XDD1_3580	COG3776	membrane
XDD1_3582	COG2217	Heavy metal translocating P-type atpase
XDD1_3583	COG0425	Belongs to the sulfur carrier protein TusA family
XDD1_3584	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XDD1_3586	COG0318	PFAM AMP-dependent synthetase and ligase
XDD1_3586	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XDD1_3586	COG1028	Short-chain dehydrogenase reductase Sdr
XDD1_3586	COG3321	synthase
XDD1_3586	COG0300	oxidoreductase activity
XDD1_3587	COG2271	Major facilitator Superfamily
XDD1_3588	COG0584	glycerophosphoryl diester phosphodiesterase
XDD1_3589	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XDD1_3590	COG1053	succinate dehydrogenase
XDD1_3591	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XDD1_3592	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XDD1_3593	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XDD1_3596	COG4770	biotin carboxylase activity
XDD1_3598	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XDD1_3599	COG1914	H( )-stimulated, divalent metal cation uptake system
XDD1_3607	COG0138	bifunctional purine biosynthesis protein purh
XDD1_3608	COG0151	Belongs to the GarS family
XDD1_3610	COG0776	regulation of translation
XDD1_3611	COG3068	Protein conserved in bacteria
XDD1_3612	COG1515	deoxyribonuclease V activity
XDD1_3614	COG2816	NAD+ diphosphatase activity
XDD1_3615	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XDD1_3616	COG0352	thiamine-phosphate diphosphorylase activity
XDD1_3617	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XDD1_3619	COG2022	thiamine diphosphate biosynthetic process
XDD1_3621	COG1051	belongs to the nudix hydrolase family
XDD1_3622	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XDD1_3625	COG2223	nitrite transmembrane transporter activity
XDD1_3626	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XDD1_3628	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XDD1_3629	COG2909	trisaccharide binding
XDD1_3631	COG0058	SHG alpha-glucan phosphorylase activity
XDD1_3632	COG1640	4-alpha-glucanotransferase
XDD1_3633	COG3833	ABC-type maltose transport systems, permease component
XDD1_3634	COG1175	transmembrane transport
XDD1_3635	COG2182	Extracellular solute-binding protein
XDD1_3636	COG3842	ATPase activity
XDD1_3637	COG4580	involved in the transport of maltose and maltodextrins
XDD1_3639	COG0726	polysaccharide deacetylase
XDD1_3640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XDD1_3641	COG0085	RNA polymerase activity
XDD1_3642	COG0222	ribosome binding
XDD1_3643	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XDD1_3644	COG0081	regulation of translation
XDD1_3645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XDD1_3646	COG0250	Participates in transcription elongation, termination and antitermination
XDD1_3647	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XDD1_3648	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XDD1_3649	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XDD1_3650	COG0049	tRNA binding
XDD1_3651	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XDD1_3652	COG2168	tRNA wobble position uridine thiolation
XDD1_3653	COG2923	Belongs to the DsrF TusC family
XDD1_3654	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
XDD1_3655	COG2964	Protein conserved in bacteria
XDD1_3656	COG0545	Peptidyl-prolyl cis-trans isomerase
XDD1_3657	COG2900	Belongs to the SlyX family
XDD1_3658	COG1047	Peptidyl-prolyl cis-trans
XDD1_3659	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
XDD1_3660	COG0488	(ABC) transporter
XDD1_3661	COG0583	DNA-binding transcription factor activity
XDD1_3662	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XDD1_3663	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XDD1_3663	COG1263	PTS System
XDD1_3665	COG3089	Belongs to the UPF0270 family
XDD1_3666	COG3954	Phosphoribulokinase
XDD1_3667	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XDD1_3668	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XDD1_3670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XDD1_3671	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XDD1_3673	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XDD1_3674	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
XDD1_3675	COG3084	Protein conserved in bacteria
XDD1_3681	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XDD1_3682	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XDD1_3684	COG1070	Carbohydrate kinase
XDD1_3685	COG2390	Transcriptional regulator
XDD1_3688	COG1172	Belongs to the binding-protein-dependent transport system permease family
XDD1_3690	COG1830	Aldolase
XDD1_3691	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
XDD1_3692	COG0076	glutamate decarboxylase activity
XDD1_3693	COG1763	Mo-molybdopterin cofactor biosynthetic process
XDD1_3694	COG0746	molybdenum cofactor guanylyltransferase activity
XDD1_3701	COG3209	COG3209 Rhs family protein
XDD1_3710	COG3209	COG3209 Rhs family protein
XDD1_3713	COG3501	Rhs element vgr protein
XDD1_3720	COG3209	COG3209 Rhs family protein
XDD1_3733	COG3209	COG3209 Rhs family protein
XDD1_3736	COG3501	Rhs element vgr protein
XDD1_3745	COG3209	COG3209 Rhs family protein
XDD1_3745	COG4104	PAAR repeat-containing protein
XDD1_3747	COG3501	Rhs element vgr protein
XDD1_3769	COG1295	ribonuclease BN
XDD1_3770	COG1942	4-Oxalocrotonate Tautomerase
XDD1_3774	COG0612	Peptidase, M16
XDD1_3775	COG2200	EAL domain
XDD1_3775	COG2199	diguanylate cyclase activity
XDD1_3776	COG4608	Belongs to the ABC transporter superfamily
XDD1_3777	COG0444	Belongs to the ABC transporter superfamily
XDD1_3778	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XDD1_3779	COG0601	transmembrane transport
XDD1_3780	COG0747	negative chemotaxis
XDD1_3790	COG0751	glycine-tRNA ligase activity
XDD1_3791	COG0752	glycyl-tRNA synthetase alpha subunit
XDD1_3792	COG2818	Glycosylase
XDD1_3797	COG3977	Valine--pyruvate aminotransferase
XDD1_3798	COG5645	(Lipo)protein
XDD1_3799	COG0823	Involved in the tonB-independent uptake of proteins
XDD1_3800	COG2860	membrane
XDD1_3802	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XDD1_3803	COG0194	GDP metabolic process
XDD1_3805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XDD1_3806	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XDD1_3808	COG0786	glutamate:sodium symporter activity
XDD1_3809	COG2233	PERMEase
XDD1_3811	COG0456	acetyltransferase
XDD1_3812	COG1490	D-aminoacyl-tRNA deacylase activity
XDD1_3816	COG1011	Hydrolase
XDD1_3823	COG2826	transposase and inactivated derivatives, IS30 family
XDD1_3824	COG1470	cell adhesion involved in biofilm formation
XDD1_3824	COG1388	LysM domain
XDD1_3825	COG3335	DDE superfamily endonuclease
XDD1_3835	COG2204	response regulator
XDD1_3836	COG2337	Toxic component of a toxin-antitoxin (TA) module
XDD1_3840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XDD1_3843	COG2252	PERMEase
XDD1_3848	COG3157	Type VI secretion system effector, Hcp
XDD1_3849	COG0765	amino acid transport
XDD1_3850	COG0765	amino acid transport
XDD1_3851	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XDD1_3852	COG0704	Plays a role in the regulation of phosphate uptake
XDD1_3853	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XDD1_3854	COG0581	inorganic phosphate transmembrane transporter activity
XDD1_3855	COG0573	inorganic phosphate transmembrane transporter activity
XDD1_3856	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XDD1_3863	COG0745	RESPONSE REGULATOR receiver
XDD1_3864	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XDD1_3865	COG2183	response to ionizing radiation
XDD1_3866	COG1918	ferrous iron import across plasma membrane
XDD1_3870	COG0583	DNA-binding transcription factor activity
XDD1_3874	COG2801	Transposase and inactivated derivatives
XDD1_3875	COG3335	DDE superfamily endonuclease
XDD1_3877	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XDD1_3877	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XDD1_3886	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XDD1_3890	COG0596	Alpha beta hydrolase
XDD1_3891	COG1040	competence protein
XDD1_3892	COG0316	Belongs to the HesB IscA family
XDD1_3892	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XDD1_3893	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XDD1_3894	COG0705	Rhomboid family
XDD1_3895	COG1349	DNA-binding transcription factor activity
XDD1_3896	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
XDD1_3901	COG3335	DDE superfamily endonuclease
XDD1_3904	COG2188	Transcriptional regulator
XDD1_3906	COG3457	Alanine racemase
XDD1_3908	COG1735	metal-dependent hydrolase with the TIM-barrel fold
XDD1_3911	COG0626	cystathionine gamma-synthase activity
XDD1_3917	COG2030	dehydratase
XDD1_3917	COG1012	belongs to the aldehyde dehydrogenase family
XDD1_3918	COG3396	Phenylacetate-CoA oxygenase
XDD1_3919	COG3460	Phenylacetate-CoA oxygenase
XDD1_3920	COG3396	Phenylacetate-CoA oxygenase
XDD1_3921	COG2151	metal-sulfur cluster biosynthetic enzyme
XDD1_3922	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XDD1_3923	COG1024	Enoyl-CoA hydratase
XDD1_3924	COG1024	Enoyl-CoA hydratase
XDD1_3925	COG1250	3-hydroxyacyl-CoA dehydrogenase
XDD1_3926	COG2050	protein possibly involved in aromatic compounds catabolism
XDD1_3927	COG0183	Belongs to the thiolase family
XDD1_3928	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XDD1_3929	COG2814	Major facilitator Superfamily
XDD1_3931	COG3335	DDE superfamily endonuclease
XDD1_3939	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XDD1_3941	COG2188	Transcriptional regulator
XDD1_3942	COG1368	sulfuric ester hydrolase activity
XDD1_3945	COG3276	selenocysteine insertion sequence binding
XDD1_3954	COG1921	L-seryl-tRNASec selenium transferase activity
XDD1_3955	COG3058	Necessary for formate dehydrogenase activity
XDD1_3958	COG2864	formate dehydrogenase
XDD1_3960	COG0437	4 iron, 4 sulfur cluster binding
XDD1_3961	COG3383	formate dehydrogenase (NAD+) activity
XDD1_3961	COG0243	molybdopterin cofactor binding
XDD1_3962	COG3383	formate dehydrogenase (NAD+) activity
XDD1_3962	COG0243	molybdopterin cofactor binding
XDD1_3963	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XDD1_3971	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XDD1_3972	COG0706	membrane insertase activity
XDD1_3973	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XDD1_3974	COG0594	ribonuclease P activity
XDD1_p0001	COG3423	Transcriptional regulator