locus-tag class description D3790_00005 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D3790_00060 ENOG4108JDX DNA polymerase iii, epsilon subunit D3790_00065 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3790_00070 ENOG4105D1A Methyltransferase D3790_00075 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D3790_00080 ENOG4105E9H Lytic Murein transglycosylase D3790_00085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3790_00090 ENOG4105F38 ABC transporter, permease D3790_00095 ENOG4105D38 putrescine abc transporter D3790_00105 ENOG4107RUE extracellular solute-binding protein family 1 D3790_00120 ENOG4107RRE RNA-directed DNA polymerase D3790_00180 ENOG4105CS6 Rhs element vgr protein D3790_00245 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase D3790_00250 ENOG4108M1A Chitin-binding protein D3790_00270 ENOG410600T transposase D3790_00375 ENOG4105D5K Hemolysin activator protein D3790_00465 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D3790_00475 ENOG4105C7K acetolactate synthase D3790_00480 ENOG4105C2C drug resistance transporter, Bcr CflA D3790_00485 ENOG4105CHR reductase D3790_00505 ENOG4108J1Q D3790_00530 ENOG4105D9N nucleoside D3790_00570 ENOG4105VUH addiction module killer protein D3790_00575 ENOG4105YES addiction module antidote protein D3790_00665 ENOG4105CDU Replicative dna helicase D3790_00695 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D3790_00715 ENOG4108UUM single-stranded DNA-binding protein D3790_00725 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_00830 ENOG4105D5K Hemolysin activator protein D3790_00850 ENOG4105CNA YD repeat protein D3790_00860 ENOG4105CS6 Rhs element vgr protein D3790_00870 ENOG4105D5G Transposase D3790_00885 ENOG4105DFP Integrase D3790_00895 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D3790_00900 ENOG4105WQ3 Rna-binding protein D3790_00920 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3790_00925 ENOG4106B0W Curli production assembly transport component CsgG D3790_00935 ENOG4107Y60 (LipO)protein D3790_00940 ENOG4105UQX Mate efflux family protein D3790_00975 ENOG4105D2N Aldolase D3790_00980 ENOG4105BZA Phosphoglycerate kinase D3790_00985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D3790_00990 ENOG4105CV1 Transketolase (EC 2.2.1.1) D3790_00995 ENOG4105D7V transposase D3790_01005 ENOG4105CJ2 (LipO)protein D3790_01010 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) D3790_01015 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D3790_01020 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D3790_01025 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D3790_01030 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D3790_01035 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D3790_01040 ENOG4105F7V ErfK ybiS ycfS ynhG family protein D3790_01045 ENOG4105E7A Glutamine amidotransferase D3790_01050 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D3790_01055 ENOG4107QPN acyl-Coa dehydrogenase D3790_01060 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D3790_01065 ENOG4105RQF LysR family Transcriptional regulator D3790_01070 ENOG4105EJC lysr family transcriptional regulator D3790_01085 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) D3790_01090 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D3790_01095 ENOG4105D7Z glutathione synthase D3790_01100 ENOG4108UJU UPF0301 protein D3790_01105 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D3790_01110 ENOG4105CZX twitching motility protein D3790_01115 ENOG4105DFA alanine racemase domain protein D3790_01120 ENOG4105II7 pyrroline-5-carboxylate reductase D3790_01125 ENOG4108VIA integral membrane protein D3790_01130 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D3790_01135 ENOG4105CSA Coproporphyrinogen iii oxidase D3790_01140 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3790_01145 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3790_01150 ENOG4105CC0 LysR family Transcriptional regulator D3790_01160 ENOG4108V1U phospholipid-binding protein D3790_01170 ENOG4105K33 Periplasmic Protein D3790_01175 ENOG4105CSV Glutaminase D3790_01180 ENOG41090ED Protein with unknown function (DUF469) D3790_01185 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D3790_01190 ENOG4105CEN a g-specific adenine glycosylase D3790_01195 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) D3790_01200 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D3790_01230 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures D3790_01250 ENOG4108J1Q D3790_01285 ENOG4105CVR type I restriction-modification system D3790_01295 ENOG4105DZR Type I site-specific deoxyribonuclease D3790_01300 ENOG4108J1Q D3790_01315 ENOG4106SDP Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control D3790_01330 ENOG4105JAB phenazine biosynthesis protein, phzf family D3790_01350 ENOG41088CC tellurite resistance protein tehB D3790_01360 ENOG4105E1F short-chain dehydrogenase reductase D3790_01420 ENOG4108SIC Transcriptional regulator D3790_01425 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D3790_01430 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D3790_01435 ENOG4108IJ0 Aspartate ammonia-lyase D3790_01445 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D3790_01450 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D3790_01455 ENOG4108ZVF (LipO)protein D3790_01460 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D3790_01465 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D3790_01470 ENOG4105KPY Small multidrug resistance protein D3790_01475 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_01490 ENOG4105CJP fad dependent oxidoreductase D3790_01500 ENOG4105C26 Dehydrogenase D3790_01515 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D3790_01520 ENOG4108WPU DNA polymerase III subunit psi D3790_01525 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D3790_01550 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_01605 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_01635 ENOG4108J1Q D3790_01650 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_01660 ENOG4108UUM single-stranded DNA-binding protein D3790_01680 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D3790_01715 ENOG4105CDU Replicative dna helicase D3790_01735 ENOG4105CS6 Rhs element vgr protein D3790_01745 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_01775 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures D3790_01795 ENOG4105E5H Transposase D3790_01800 ENOG4108YXQ IS66 Orf2 family protein D3790_01815 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_01860 ENOG4105C26 Dehydrogenase D3790_01865 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) D3790_01875 ENOG4107RUZ Sss sodium solute transporter superfamily D3790_01880 ENOG4105D7K pfkb domain protein D3790_01890 ENOG4105DH8 myo-inositol catabolism D3790_01920 ENOG4108TEB UPF0114 protein D3790_01935 ENOG4105DAX Pfam:DUF2983 D3790_01975 ENOG410600T transposase D3790_02035 ENOG4108WC9 type VI secretion system effector, hcp1 family D3790_02065 ENOG410600T transposase D3790_02070 ENOG4105DNE Transposase D3790_02090 ENOG4105C6T cysteine synthase D3790_02100 ENOG4108IJ6 ABC transporter D3790_02105 ENOG4105ECW sulfate abc transporter D3790_02110 ENOG4108I5D sulfate abc transporter D3790_02115 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein D3790_02150 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D3790_02155 ENOG4108Z1B Cyclase dehydrase D3790_02160 ENOG4105VDB UPF0125 protein D3790_02165 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D3790_02170 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D3790_02175 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D3790_02180 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D3790_02185 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D3790_02200 ENOG4105C1J atp-dependent rna helicase D3790_02205 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D3790_02210 ENOG4105EMN RNA polymerase sigma factor D3790_02225 ENOG4105WMJ Positive regulator of sigma E, RseC MucC D3790_02230 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D3790_02235 ENOG4105C3F Signal peptidase i D3790_02240 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D3790_02250 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) D3790_02255 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D3790_02260 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D3790_02265 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D3790_02275 ENOG4105D03 DNA-3-methyladenine glycosylase II D3790_02280 ENOG4108Z6B deaminase D3790_02285 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) D3790_02290 ENOG4107QIK phosphoribosylformylglycinamidine synthase D3790_02295 ENOG4107WP9 Histidine kinase D3790_02300 ENOG4108SKK alpha helix protein D3790_02305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3790_02310 ENOG4105C4K Nad synthetase D3790_02315 ENOG4108YZA Nitrogen regulatory protein pii D3790_02320 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D3790_02325 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D3790_02330 ENOG4105D8G Major Facilitator superfamily D3790_02335 ENOG4105ECY inositol monophosphatase D3790_02340 ENOG4105CVS RNA methyltransferase TrmH family, group 1 D3790_02345 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D3790_02350 ENOG4105C3J Cysteine desulfurase D3790_02355 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D3790_02360 ENOG4108Z4V iron-sulfur cluster assembly D3790_02365 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) D3790_02370 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB D3790_02375 ENOG4108ZIT Ferredoxin, 2FE-2S D3790_02380 ENOG4105WVQ Fe-S assembly protein IscX D3790_02385 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D3790_02395 ENOG4105DN3 alpha-2-macroglobulin domain protein D3790_02405 ENOG4108JQB penicillin-binding protein 1C D3790_02415 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D3790_02420 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D3790_02435 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D3790_02445 ENOG4105CUT histidyl-tRNA synthetase D3790_02450 ENOG4105N21 Membrane D3790_02455 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D3790_02460 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D3790_02480 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D3790_02490 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D3790_02495 ENOG4105C6Z Gluconate D3790_02500 ENOG4105K4U addiction module toxin, RelE StbE family D3790_02535 ENOG4108UR8 BAX protein D3790_02550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D3790_02550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D3790_02610 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D3790_02615 ENOG41067QW Transcriptional regulator D3790_02625 ENOG4108UV1 cellular component movement D3790_02650 ENOG4105CS6 Rhs element vgr protein D3790_02660 ENOG410600T transposase D3790_02710 ENOG4105ZTC transcriptional activator, Ogr delta D3790_02715 ENOG4105Z2P Protein of unknown function (DUF465) D3790_02725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D3790_02760 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3790_02765 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3790_02770 ENOG4105DXD 2-methylcitrate dehydratase D3790_02775 ENOG4105BZN citrate synthase D3790_02780 ENOG4105CR4 methylisocitrate lyase D3790_02785 ENOG4108JU7 Transcriptional regulator D3790_02810 ENOG4105X58 receptor D3790_02830 ENOG410600T transposase D3790_02845 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) D3790_02850 ENOG4105C26 Dehydrogenase D3790_02855 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) D3790_02860 ENOG4105C94 Transporter D3790_02870 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D3790_02875 ENOG4105CIN aminoacyl-histidine dipeptidase D3790_02880 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) D3790_02885 ENOG4105V1F Fermentation respiration switch protein D3790_02890 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) D3790_02895 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D3790_02900 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D3790_02905 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D3790_02915 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) D3790_02925 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D3790_02930 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D3790_02935 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D3790_02960 ENOG4105D9M gamma-glutamylcysteine synthetase D3790_02965 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) D3790_02970 ENOG4105D5G Transposase D3790_02975 ENOG4108JU6 CBS domain protein D3790_02980 ENOG4106KVJ cytochrome C assembly protein D3790_02985 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D3790_02990 ENOG4105K5M 30s ribosomal protein S16 D3790_02995 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D3790_03000 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D3790_03005 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D3790_03010 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D3790_03015 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D3790_03020 ENOG4105EHE chorismate mutase- prephenate dehydrogenase D3790_03025 ENOG4105CQC Prephenate dehydratase D3790_03030 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA D3790_03035 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D3790_03040 ENOG4105C34 Pseudouridine synthase D3790_03045 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D3790_03050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3790_03075 ENOG4105T42 (LipO)protein D3790_03080 ENOG4105JIM Phosphatidylserine synthase D3790_03085 ENOG4105CD5 CoA-binding domain protein D3790_03090 ENOG4106IUH DTW domain containing protein D3790_03095 ENOG4105EIB trna rrna methyltransferase D3790_03105 ENOG4105CNM Receptor D3790_03115 ENOG4105DQ5 transport system permease protein D3790_03120 ENOG4105TVJ transport system, permease D3790_03125 ENOG4105E0A ABC, transporter D3790_03130 ENOG4108819 ferric iron reductase D3790_03135 ENOG4105DY8 decarboxylase D3790_03140 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) D3790_03150 ENOG4105CIH Imidazole acetol-phosphate transaminase D3790_03155 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3790_03160 ENOG4105CW7 secretion protein, HlyD family D3790_03165 ENOG4105NTK Transcriptional repressor Mpra D3790_03170 ENOG4105ZED uncharacterized protein ygaH D3790_03175 ENOG4108UMN azlc family D3790_03180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3790_03185 ENOG4105VEQ Cold shock protein D3790_03190 ENOG4107Z6W Protein CrcB homolog D3790_03195 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D3790_03200 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D3790_03205 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D3790_03210 ENOG4108Z43 UPF0250 protein D3790_03215 ENOG4105DZ1 carboxypeptidase D3790_03220 ENOG4105K6T rare lipoprotein A D3790_03225 ENOG4105CNI cell division protein FtsW D3790_03230 ENOG4105CJN penicillin-binding protein D3790_03235 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D3790_03240 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D3790_03250 ENOG4105DJF DNA polymerase III, delta' subunit D3790_03255 ENOG4108U2H Rare lipoprotein B D3790_03260 ENOG4105C8T Leucyl-tRNA synthetase D3790_03265 ENOG4105CDA abc transporter atp-binding protein D3790_03270 ENOG4105DRP amino acid AbC transporter D3790_03275 ENOG4105EAD ABC transporter D3790_03280 ENOG4107RP9 extracellular solute-binding protein, family 3 D3790_03285 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D3790_03290 ENOG4108JU5 Magnesium and cobalt efflux protein D3790_03295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D3790_03300 ENOG4105C9A Phoh family D3790_03305 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D3790_03310 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D3790_03355 ENOG4105E2R ROK family D3790_03360 ENOG4105CE4 GlcNAc 6-P deacetylase D3790_03365 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D3790_03370 ENOG4105CI1 PTS System D3790_03380 ENOG4108J1Q D3790_03390 ENOG4105NNH LexA regulated protein D3790_03395 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) D3790_03400 ENOG41090R7 Ferric uptake D3790_03410 ENOG4105CX6 glutaminyL-tRNA synthetase D3790_03440 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_03465 ENOG4108J1Q D3790_03480 ENOG4105DDI hemolysin-type calcium-binding region D3790_03495 ENOG4105DFG type I secretion outer membrane protein D3790_03515 ENOG4108JJA ABC, transporter D3790_03520 ENOG4105C42 Type I secretion membrane fusion protein (HlyD D3790_03535 ENOG4108RC6 RTX toxin D3790_03540 ENOG4105EUK rtx toxin RtxA D3790_03555 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3790_03560 ENOG4105EV9 Alpha Beta Hydrolase D3790_03565 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) D3790_03570 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 D3790_03580 ENOG4105EST Metal Dependent Phosphohydrolase D3790_03585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3790_03595 ENOG4105EEX Two component transcriptional regulator (Winged helix family D3790_03600 ENOG4105C08 Histidine kinase D3790_03605 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) D3790_03610 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D3790_03615 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D3790_03625 ENOG4105XIQ Protein of unknown function (DUF2517) D3790_03630 ENOG4107QNR UPF0135 protein D3790_03640 ENOG4105E5M Multidrug resistance protein D D3790_03650 ENOG4105BZN citrate synthase D3790_03655 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D3790_03660 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein D3790_03665 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D3790_03670 ENOG4105E33 succinate dehydrogenase D3790_03675 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D3790_03680 ENOG4105C7S Dehydrogenase D3790_03685 ENOG4105CMV Succinyl-CoA synthetase subunit beta D3790_03690 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D3790_03695 ENOG4105C4M (Ubiquinol oxidase) subunit I D3790_03700 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D3790_03710 ENOG4105KJB cyd operon protein YbgE D3790_03715 ENOG4107YD3 Thioesterase D3790_03720 ENOG4105E02 MotA TolQ exbB proton channel D3790_03725 ENOG4105M8F Biopolymer transport protein exbD tolR D3790_03730 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA D3790_03735 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D3790_03740 ENOG4105KCK Peptidoglycan-associated lipoprotein D3790_03745 ENOG4105UFD tol-pal system protein YbgF D3790_03760 ENOG4106Z1T Nicotinamide Mononucleotide Transporter D3790_03765 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D3790_03770 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D3790_03785 ENOG4105DKW ABC transporter D3790_03795 ENOG410680R Protein of unknown function (DUF2592) D3790_03800 ENOG41079KZ Major Facilitator Superfamily D3790_03805 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D3790_03810 ENOG4105E0C molybdate abc transporter D3790_03815 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) D3790_03820 ENOG4108K4B hydrolase D3790_03825 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D3790_03835 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) D3790_03850 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D3790_03855 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3790_03860 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D3790_03865 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D3790_03870 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D3790_03875 ENOG4105CHW UPF0052 protein D3790_03880 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D3790_03885 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D3790_03890 ENOG4105M00 molybdopterin converting factor, subunit 1 D3790_03895 ENOG4108ZAF Molybdopterin D3790_03900 ENOG4105HFZ Membrane D3790_03910 ENOG4107QWP ABC-2 type transporter D3790_03915 ENOG4107QWP ABC-2 type transporter D3790_03920 ENOG4105CJ1 ABC, transporter D3790_03930 ENOG4107MVR Transcriptional regulator D3790_03935 ENOG4105C1J atp-dependent rna helicase D3790_03940 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) D3790_03960 ENOG4105CNA YD repeat protein D3790_03980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D3790_03985 ENOG41067QW Transcriptional regulator D3790_04020 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D3790_04025 ENOG41067QW Transcriptional regulator D3790_04040 ENOG4105CNA YD repeat protein D3790_04055 ENOG4105CS6 Rhs element vgr protein D3790_04085 ENOG4105E68 Sulfatase D3790_04090 ENOG4105PAN UPF0352 protein D3790_04095 ENOG4106V8H Nucleoid-associated protein D3790_04100 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D3790_04105 ENOG4105CFI type iii restriction protein res subunit D3790_04110 ENOG4105I08 Pseudouridine synthase D3790_04115 ENOG4105C2C drug resistance transporter, Bcr CflA D3790_04120 ENOG4105HG6 D3790_04125 ENOG4107TT5 NLP P60 protein D3790_04130 ENOG41076MN Phosphoesterase, PA-phosphatase related D3790_04145 ENOG4105PTV Nudix Hydrolase D3790_04150 ENOG4105CYM Glutathione S-transferase D3790_04155 ENOG4105ECP epimerase D3790_04160 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D3790_04165 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D3790_04170 ENOG4105E96 Colicin v production protein D3790_04175 ENOG4108S3P Sporulation domain protein D3790_04180 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D3790_04185 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D3790_04190 ENOG4105DQR SNARE associated Golgi D3790_04195 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D3790_04200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D3790_04205 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) D3790_04220 ENOG4105DHQ Histidine kinase D3790_04235 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D3790_04240 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) D3790_04255 ENOG4105MH2 YfcL protein D3790_04260 ENOG4108BPE -transporting atpase D3790_04265 ENOG4105EJ9 Membrane D3790_04270 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D3790_04280 ENOG4105C85 amino acid D3790_04285 ENOG4105C84 Histidine ammonia-lyase D3790_04290 ENOG4105CGP Urocanate hydratase D3790_04305 ENOG41088SP formiminoglutamate hydrolase D3790_04310 ENOG4105CI2 imidazolone-5-propionate hydrolase D3790_04315 ENOG4108DG9 Smr protein MutS2 D3790_04320 ENOG4108BY2 phosphohistidine phosphatase D3790_04325 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3790_04330 ENOG4105CHU acetyl-coa acetyltransferase D3790_04335 ENOG4105KZW UPF0381 protein D3790_04340 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D3790_04345 ENOG410903C (LipO)protein D3790_04365 ENOG4105PI0 Ferredoxin D3790_04410 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D3790_04425 ENOG4105VRT cytoplasmic protein D3790_04430 ENOG4105D9N nucleoside D3790_04435 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D3790_04440 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) D3790_04445 ENOG4105EXN Sulfate transport protein CysZ D3790_04450 ENOG4105C6T cysteine synthase D3790_04455 ENOG4105KZ7 phosphocarrier protein hpr D3790_04465 ENOG4105C5Y PTS System D3790_04475 ENOG4108WC9 type VI secretion system effector, hcp1 family D3790_04500 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D3790_04520 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D3790_04530 ENOG4105EMU Dehydrogenase D3790_04540 ENOG4105D5G Transposase D3790_04560 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D3790_04565 ENOG4105XPH Ferredoxin D3790_04570 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D3790_04575 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D3790_04580 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3790_04585 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3790_04590 ENOG4105BZU Histidine kinase D3790_04595 ENOG41068CG regulatoR D3790_04600 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC D3790_04615 ENOG4105E0U tyrosine-specific transport protein D3790_04620 ENOG4108UII YfaZ family D3790_04625 ENOG4105CEY Amp-dependent synthetase and ligase D3790_04630 ENOG4105DNI Converts SHCHC to OSB (By similarity) D3790_04635 ENOG4108IPT Naphthoate synthase D3790_04640 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D3790_04645 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D3790_04655 ENOG4105E4F Isochorismate synthase D3790_04660 ENOG4108TUY outer membrane protein PgaA D3790_04665 ENOG4107BJW polysaccharide deacetylase D3790_04670 ENOG4105CND Glycosyl transferase, family 2 D3790_04680 ENOG4108WS1 D3790_04685 ENOG4108KHX Diguanylate cyclase D3790_04690 ENOG41090EK ompa motb domain protein D3790_04695 ENOG4105BZU Histidine kinase D3790_04725 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC D3790_04735 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) D3790_04740 ENOG4105C94 Transporter D3790_04750 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3790_04755 ENOG4105C8S subunit m D3790_04760 ENOG4105D65 subunit l D3790_04765 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3790_04770 ENOG4107UFS subunit j D3790_04775 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3790_04785 ENOG4108IEH NADH dehydrogenase subunit g D3790_04790 ENOG4107QIZ NADH dehydrogenase D3790_04795 ENOG4105GKE subunit e D3790_04800 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3790_04805 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3790_04810 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D3790_04820 ENOG4107NQ8 LysR family Transcriptional regulator D3790_04825 ENOG4105CHM Aminotransferase D3790_04835 ENOG4107QWE )-transporter D3790_04840 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 D3790_04845 ENOG4105PQ6 UPF0208 membrane protein D3790_04850 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D3790_04855 ENOG4105C6K Malic enzyme D3790_04915 ENOG410600T transposase D3790_04925 ENOG4105IBP Cyclic peptide transporter D3790_04985 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D3790_04995 ENOG4105DE4 1-phosphofructokinase D3790_05000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D3790_05005 ENOG4105HMI Membrane D3790_05010 ENOG4105DUM transcriptional regulator, lysR family D3790_05015 ENOG4108IQI permease D3790_05025 ENOG4105EHG Permease protein D3790_05030 ENOG4105E0A ABC, transporter D3790_05035 ENOG4105D05 Receptor D3790_05045 ENOG4105CUB amino acid D3790_05050 ENOG4105CXG d-lactate dehydrogenase D3790_05055 ENOG4105CJB Exodeoxyribonuclease I D3790_05060 ENOG41090HJ UPF0265 protein D3790_05075 ENOG4105EQN UPF0261 protein D3790_05100 ENOG4107QQB Ribonuclease E D3790_05110 ENOG4105EI2 Pseudouridine synthase D3790_05115 ENOG4108UHJ MAF-like protein D3790_05120 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D3790_05125 ENOG4105VGS 50s ribosomal protein l32 D3790_05130 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D3790_05135 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3790_05140 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D3790_05145 ENOG4105CHR reductase D3790_05150 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D3790_05155 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D3790_05160 ENOG4105YAZ 4-amino-4-deoxychorismate lyase D3790_05165 ENOG4105HHA aminodeoxychorismate lyase D3790_05170 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D3790_05175 ENOG4107QRG dna polymerase iii D3790_05180 ENOG4105F8V Hydrolase, tatD family D3790_05185 ENOG4105K59 histidine triad (HIT) protein D3790_05190 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) D3790_05200 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) D3790_05205 ENOG4105CEP NADH dehydrogenase D3790_05210 ENOG4107MBR 17 kDa surface antigen D3790_05215 ENOG4108JA2 transcriptioN-repair coupling factor D3790_05220 ENOG4105D60 lipoprotein releasing system transmembrane protein D3790_05225 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D3790_05230 ENOG4105D60 lipoprotein releasing system transmembrane protein D3790_05240 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D3790_05260 ENOG4105EZE Cupin 4 family protein D3790_05270 ENOG4105XJC Two component transcriptional regulator (Winged helix family D3790_05275 ENOG4107QTF adenylosuccinate lyase D3790_05280 ENOG41075W9 High frequency lysogenization protein HflD homolog D3790_05285 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D3790_05295 ENOG4108R99 pseudouridine synthase D3790_05300 ENOG4108HMX isocitrate dehydrogenase (NADP) D3790_05330 ENOG4105BZG amino acid carrier protein D3790_05335 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D3790_05340 ENOG4105UEI Transcriptional Regulator AraC Family D3790_05350 ENOG4105C85 amino acid D3790_05355 ENOG4105VEQ Cold shock protein D3790_05360 ENOG4105DWF phosphomethylpyrimidine kinase D3790_05365 ENOG4105EIE fructose-bisphosphate aldolase D3790_05370 ENOG4105CFP Peptidase U32 D3790_05375 ENOG4105F27 Major Facilitator D3790_05380 ENOG4105E3W Two component transcriptional regulator (Winged helix family D3790_05385 ENOG4105BZS acriflavin resistance protein D3790_05390 ENOG4105BZS acriflavin resistance protein D3790_05395 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3790_05405 ENOG4105CJW magnesium transporter D3790_05410 ENOG4105C9X ppx gppa phosphatase D3790_05415 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D3790_05420 ENOG4108MK9 spermidine N(1)-acetyltransferase D3790_05425 ENOG4108V3E phosphoribosylglycinamide formyltransferase D3790_05430 ENOG4105CXB phosphoribosylaminoimidazole synthetase D3790_05435 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D3790_05440 ENOG4105C2W permease D3790_05445 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) D3790_05450 ENOG4105K89 arsenate reductase D3790_05455 ENOG4105ERG peptidase m48, ste24p D3790_05460 ENOG4105C02 permease D3790_05465 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3790_05470 ENOG4105RH4 Glycine cleavage system transcriptional repressor D3790_05475 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3790_05480 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D3790_05485 ENOG4105C8V SAICAR synthetase D3790_05500 ENOG4108VMM UPF0756 membrane protein D3790_05505 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) D3790_05520 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D3790_05525 ENOG4105KUZ arsenate reductase D3790_05530 ENOG4105WH1 Two component transcriptional regulator luxr family D3790_05535 ENOG4105C6K Malic enzyme D3790_05550 ENOG4105CUG Oligopeptidase b D3790_05580 ENOG4107QSI ABC, transporter D3790_05585 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D3790_05590 ENOG4108JQ2 peptide transport system atp-binding protein D3790_05595 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein D3790_05600 ENOG4108EU3 peptide transport system, permease D3790_05605 ENOG4108I5W peptide transport system, permease protein D3790_05610 ENOG4108HIY periplasmic D3790_05615 ENOG4105E51 psp operon transcriptional activator D3790_05620 ENOG41087YS Phage shock protein A D3790_05625 ENOG4105YYT phage shock protein B D3790_05630 ENOG4105FM1 phage shock protein C D3790_05635 ENOG4105CM6 amino acid regulated cytosolic protein D3790_05650 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D3790_05655 ENOG4107RX3 Mg2 transporter protein cora family protein D3790_05660 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) D3790_05675 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_05685 ENOG4105C85 amino acid D3790_05715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3790_05735 ENOG4105WH1 Two component transcriptional regulator luxr family D3790_05740 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D3790_05745 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D3790_05840 ENOG4105H4F exported protein D3790_05880 ENOG4105D5G Transposase D3790_05920 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) D3790_05925 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3790_05930 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) D3790_05985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3790_06075 ENOG4105MWK D-amino acid dehydrogenase, small subunit D3790_06080 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D3790_06085 ENOG4105DSB aldose 1-epimerase D3790_06095 ENOG4105E0X reductase D3790_06100 ENOG4105VUT cytoplasmic protein D3790_06120 ENOG4108RWI nicotinamidase D3790_06125 ENOG4105HDK L-asparaginase D3790_06135 ENOG4105D07 Signal peptide peptidase, SppA D3790_06140 ENOG41069NU Nitroreductase D3790_06145 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) D3790_06150 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D3790_06155 ENOG4105CGK Exodeoxyribonuclease III D3790_06175 ENOG4105CIY formyltetrahydrofolate deformylase D3790_06180 ENOG4105K5B UPF0225 protein D3790_06185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D3790_06190 ENOG4105C6Y Udp-glucose 6-dehydrogenase D3790_06205 ENOG4107104 thymidine kinase D3790_06210 ENOG4108EKI Dehydrogenase D3790_06215 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D3790_06220 ENOG4107QSI ABC, transporter D3790_06225 ENOG4107QSI ABC, transporter D3790_06230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3790_06235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3790_06240 ENOG4105C3U ABC transporter D3790_06245 ENOG4108JQ7 (ABC) transporter D3790_06265 ENOG4108JPW Aminotransferase D3790_06300 ENOG4105IBP Cyclic peptide transporter D3790_06315 ENOG4107SQI penicillin amidase D3790_06330 ENOG4108W5H UPF0263 protein D3790_06355 ENOG410822N TonB family D3790_06370 ENOG4105NAU thioesterase Superfamily protein D3790_06375 ENOG4107835 probably involved in intracellular septation (By similarity) D3790_06385 ENOG4108S3I UPF0259 membrane protein D3790_06390 ENOG4105EIF outer membrane protein W D3790_06395 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D3790_06400 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D3790_06405 ENOG4105DK0 Indole-3-glycerol phosphate synthase D3790_06410 ENOG4107QYG anthranilate phosphoribosyltransferase D3790_06420 ENOG4105CRQ synthase (Component I) D3790_06435 ENOG4105DB7 PHP domain protein D3790_06440 ENOG4107RTD sua5 ycio yrdc ywlc family protein D3790_06445 ENOG4105FE9 pseudouridine synthase D3790_06450 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D3790_06455 ENOG4105UBK short-chain dehydrogenase reductase D3790_06460 ENOG4105ERU peptidase D3790_06470 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D3790_06475 ENOG4107R11 Transcriptional regulator D3790_06485 ENOG4107QM5 aconitate hydratase D3790_06500 ENOG4105Q4A inner membrane protein yciS D3790_06505 ENOG4105CFV Tetratricopeptide repeat protein D3790_06510 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D3790_06515 ENOG4108ZJT translation initiation factor, Sui1 D3790_06535 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) D3790_06560 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_06575 ENOG4108J1Q D3790_06580 ENOG4105D5G Transposase D3790_06590 ENOG4108J1Q D3790_06615 ENOG4105CSM endonuclease III D3790_06625 ENOG4108UQQ Electron transport complex D3790_06645 ENOG4105DGN Electron transport complex D3790_06650 ENOG4105M9B inner membrane protein ydgK D3790_06655 ENOG4105D9R oxidoreductase D3790_06660 ENOG4105DHU Bile acid D3790_06665 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D3790_06670 ENOG4106J39 exported protein D3790_06675 ENOG4105EIP mannose-6-phosphate isomerase D3790_06680 ENOG4105C9Q fumarate hydratase class II D3790_06700 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D3790_06710 ENOG4105M5Q UPF0482 protein D3790_06715 ENOG4105EMU Dehydrogenase D3790_06725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D3790_06735 ENOG4105FQP Beta-lactamase D3790_06765 ENOG4105J7D transcriptional regulator D3790_06775 ENOG4105EF1 ribulokinase D3790_06780 ENOG4105CSW GntR family transcriptional regulator D3790_06785 ENOG41089BK Glutamine amido-transferase D3790_06845 ENOG4108UPT UPF0178 protein D3790_06855 ENOG4108S8N class II Aldolase D3790_06860 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3790_06870 ENOG4105CJP fad dependent oxidoreductase D3790_06890 ENOG4105C26 Dehydrogenase D3790_06940 ENOG4105EUK rtx toxin RtxA D3790_06945 ENOG4105C26 Dehydrogenase D3790_06950 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D3790_06955 ENOG4105EVZ LysR family transcriptional regulator D3790_06965 ENOG4107RNH Outer membrane receptor FepA D3790_06970 ENOG4108ZT1 Transcriptional regulator D3790_07020 ENOG4105E2B Taurine dioxygenase D3790_07040 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3790_07045 ENOG4105Q9Y Universal stress protein D3790_07070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3790_07105 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3790_07110 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3790_07115 ENOG4105C5D exported protein D3790_07130 ENOG4105D5Q Arginine ornithine antiporter D3790_07140 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_07160 ENOG4105CQ7 ATP-dependent helicase D3790_07170 ENOG4105WXT Conserved Protein D3790_07175 ENOG410689M (LipO)protein D3790_07180 ENOG4107H52 Dicarboxylate transport D3790_07185 ENOG4105C5I Dehydrogenase D3790_07195 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D3790_07210 ENOG4106MXH Plays an important role in the de novo pathway of purine nucleotide biosynthesis D3790_07215 ENOG4105M6F mutator MutT protein D3790_07220 ENOG4108ZZ3 UPF0260 protein D3790_07225 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase D3790_07230 ENOG4105CVE Lytic murein transglycosylase D3790_07235 ENOG4105VNG YcgL domain-containing protein D3790_07240 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D3790_07245 ENOG4107QMS site-determining protein D3790_07250 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D3790_07270 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) D3790_07275 ENOG4105CEY Amp-dependent synthetase and ligase D3790_07280 ENOG4105Y4Z Outer Membrane Lipoprotein D3790_07285 ENOG41072GX Peptidase M22 Glycoprotease D3790_07290 ENOG4105DVT helicase D3790_07310 ENOG4105M4H endoribonuclease L-psp D3790_07315 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) D3790_07320 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) D3790_07325 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D3790_07330 ENOG4106KNT transcriptional regulator D3790_07335 ENOG4105CA9 Pyruvate kinase D3790_07355 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase D3790_07360 ENOG4105DR5 peptidase D3790_07365 ENOG4105NXV High-affinity zinc uptake system protein D3790_07370 ENOG4105FDK ABC transporter D3790_07375 ENOG4105FAV ABC, transporter D3790_07410 ENOG4107EEY synthase D3790_07420 ENOG4105CHM Aminotransferase D3790_07425 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D3790_07430 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D3790_07435 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D3790_07440 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) D3790_07445 ENOG4105CDY transcriptional regulatory protein D3790_07450 ENOG4108TIT dATP pyrophosphohydrolase D3790_07455 ENOG4105C9M aspartyl-trna synthetase D3790_07460 ENOG4105WJG Glutathione D3790_07465 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) D3790_07470 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) D3790_07475 ENOG4106N3A copper homeostasis protein cutc D3790_07480 ENOG4106ZCM YecM protein D3790_07485 ENOG4105C75 arginyL-tRNA synthetase D3790_07490 ENOG4105CJR Integral membrane protein (MviN D3790_07495 ENOG4105D9U N-acetyltransferase D3790_07500 ENOG4105EV4 Multidrug resistance protein mdtH D3790_07505 ENOG4105F3T (LipO)protein D3790_07510 ENOG4107XHZ cytoplasmic chaperone TorD family protein D3790_07515 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D3790_07540 ENOG4105D29 Helix-turn-helix type 11 domain protein D3790_07550 ENOG4108X9F tail fiber protein D3790_07555 ENOG4106W3I PA-I galactophilic lectin D3790_07560 ENOG4105CHH sulfate transporter D3790_07565 ENOG4108JUA Transcriptional regulator D3790_07600 ENOG4105H3G oxidoreductase D3790_07605 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D3790_07610 ENOG41063JG Transcriptional regulator D3790_07615 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D3790_07620 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D3790_07625 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D3790_07630 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) D3790_07635 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D3790_07640 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D3790_07650 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria D3790_07655 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D3790_07660 ENOG4105C3G gtp-binding protein D3790_07665 ENOG4105DZC cytosine deaminase D3790_07715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3790_07720 ENOG4105DUX Transporter D3790_07725 ENOG4105C4M (Ubiquinol oxidase) subunit I D3790_07730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D3790_07740 ENOG4105D5M phosphate starvation-inducible protein D3790_07745 ENOG4105RWS endonuclease I D3790_07755 ENOG4108RW8 Universal stress protein F D3790_07760 ENOG4108U51 Universal stress protein D3790_07765 ENOG4105D9N nucleoside D3790_07770 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) D3790_07775 ENOG4105DD7 kinase (PfkB family D3790_07785 ENOG4105D5Q Arginine ornithine antiporter D3790_07790 ENOG4105CXN decarboxylase D3790_07830 ENOG4105C4W S-formylglutathione hydrolase D3790_07890 ENOG4105DY8 decarboxylase D3790_07905 ENOG4108K0D peptidase, M48 D3790_07940 ENOG4105DNE Transposase D3790_07960 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3790_07970 ENOG4106W3I PA-I galactophilic lectin D3790_07975 ENOG4105E5H Transposase D3790_07980 ENOG4108YXQ IS66 Orf2 family protein D3790_08000 ENOG4105VEQ Cold shock protein D3790_08040 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D3790_08095 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D3790_08100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D3790_08105 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D3790_08110 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D3790_08115 ENOG4108XTF Outer Membrane Lipoprotein D3790_08120 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) D3790_08125 ENOG4105XZD Fe-S protein D3790_08130 ENOG4108UYE Lactoylglutathione lyase D3790_08135 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) D3790_08140 ENOG4105M2J Glutaredoxin D3790_08145 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D3790_08150 ENOG4105ETE Transcriptional regulator (LacI family D3790_08155 ENOG4105F52 Transcriptional regulator D3790_08160 ENOG4105CZQ inner membrane transport protein YdhC D3790_08165 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D3790_08170 ENOG4108R6K riboflavin synthase, subunit alpha D3790_08175 ENOG4107QI1 Mate efflux family protein D3790_08195 ENOG4105CA9 Pyruvate kinase D3790_08200 ENOG4105KMX major outer membrane lipoprotein D3790_08205 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D3790_08210 ENOG4105KA0 thioesterase Superfamily protein D3790_08215 ENOG4105CQB FAD linked oxidase domain protein D3790_08220 ENOG4105IPI Membrane D3790_08225 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D3790_08230 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D3790_08240 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_08245 ENOG4107ENK receptor D3790_08250 ENOG4106QJH hemin transport protein D3790_08255 ENOG4107R4I Periplasmic binding protein D3790_08260 ENOG4105EHG Permease protein D3790_08265 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D3790_08280 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) D3790_08290 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin D3790_08300 ENOG4108QBX (LipO)protein D3790_08305 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) D3790_08310 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) D3790_08315 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D3790_08320 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D3790_08325 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D3790_08330 ENOG4105CKK Glycosyl transferase, family 2 D3790_08335 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3790_08340 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) D3790_08345 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) D3790_08350 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D3790_08355 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D3790_08370 ENOG41082NX 50s ribosomal protein l35 D3790_08375 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D3790_08380 ENOG4105C22 threonyL-tRNA synthetase D3790_08385 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D3790_08390 ENOG4105DSE periplasmic solute binding protein D3790_08395 ENOG4105DIK (ABC) transporter D3790_08400 ENOG4105CC5 ABC transporter D3790_08405 ENOG4105CC5 ABC transporter D3790_08410 ENOG4105FGM Fructosamine kinase D3790_08420 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 D3790_08425 ENOG4107K5X Membrane-bound metal-dependent hydrolase D3790_08455 ENOG4108ETY sodium dicarboxylate symporter D3790_08460 ENOG4105D0M Protease HtpX homolog D3790_08465 ENOG4105CN1 protease D3790_08470 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) D3790_08475 ENOG4108ZGC gaf domain protein D3790_08480 ENOG4105NKT exported protein D3790_08485 ENOG4108PNC copper resistance D3790_08490 ENOG4105FXM Copper resistance protein D3790_08495 ENOG41090A1 ferritin D3790_08500 ENOG4105MPK DNA polymerase III subunit theta D3790_08510 ENOG4105VBS Inherit from NOG: Secreted protein D3790_08515 ENOG4105X5C UPF0181 protein D3790_08520 ENOG4105CRQ synthase (Component I) D3790_08525 ENOG4105P8F nudix hydrolase D3790_08530 ENOG4105EJQ L-serine dehydratase D3790_08535 ENOG4108EQA pts system D3790_08540 ENOG4105ETZ PTS System D3790_08545 ENOG4105F3R pts system mannose fructose sorbose family iid D3790_08550 ENOG4108NK4 UPF0266 membrane protein D3790_08555 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) D3790_08560 ENOG4105DHI Methyltransferase D3790_08565 ENOG4105CXY transporter D3790_08570 ENOG4105BZU Histidine kinase D3790_08590 ENOG4108KX4 response regulator D3790_08595 ENOG4105CXY transporter D3790_08605 ENOG4105WH1 Two component transcriptional regulator luxr family D3790_08625 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D3790_08630 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D3790_08635 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D3790_08685 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_08710 ENOG4108Z0T Part of a sulfur-relay system (By similarity) D3790_08715 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D3790_08725 ENOG4108J1Q D3790_08735 ENOG4105K4P CoA-binding domain protein D3790_08740 ENOG4108Z5K methylglyoxal synthase D3790_08745 ENOG41088T4 Helicase IV D3790_08755 ENOG410600T transposase D3790_08790 ENOG4108J1Q D3790_08800 ENOG4108QZZ filamentous hemagglutinin D3790_08820 ENOG4108C33 Resolvase D3790_08830 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) D3790_08835 ENOG4108VYJ response regulator receiver protein D3790_08840 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3790_08845 ENOG4105BZU Histidine kinase D3790_08850 ENOG4105C8Q Methyl-accepting chemotaxis D3790_08855 ENOG4105C8Q Methyl-accepting chemotaxis D3790_08860 ENOG4108V3W Chemotaxis protein, CheW D3790_08865 ENOG4105CBS Chea signal transduction histidine kinase D3790_08870 ENOG4105ER2 Ompa motb domain protein D3790_08875 ENOG4107RD7 Flagellar Motor Protein, MotA D3790_08880 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region D3790_08885 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) D3790_08890 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D3790_08895 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D3790_08900 ENOG4105EKE dihydroorotase D3790_08920 ENOG4105DAA L-lactate D3790_08925 ENOG4105DMF Dehydrogenase D3790_08945 ENOG4105D1S lipid A biosynthesis D3790_08950 ENOG4105C72 UPF0176 protein D3790_08960 ENOG4105PVA Biofilm formation regulatory protein BssS D3790_08965 ENOG4105VEQ Cold shock protein D3790_08970 ENOG4105GSJ Inner membrane protein ylaC D3790_08985 ENOG4106IKR D3790_09005 ENOG4105PZ7 Baseplate assembly protein D3790_09015 ENOG4108NKR DNA circulation protein D3790_09025 ENOG4105EFV Major head subunit D3790_09030 ENOG4108TVE i protein D3790_09035 ENOG4107XYH virion morphogenesis protein D3790_09040 ENOG4108QUU Morphogenesis Protein D3790_09045 ENOG4105QIB mu-like prophage Flumu protein gp29 D3790_09050 ENOG4105CF2 Mu-like prophage FluMu protein GP28 D3790_09055 ENOG4108Z6H mu-like prophage Flumu protein gp27 D3790_09105 ENOG41065S5 D3790_09145 ENOG4108WTW DNA transposition protein D3790_09155 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_09230 ENOG4105CK7 Sodium proline symporter D3790_09235 ENOG4105C26 Dehydrogenase D3790_09240 ENOG4108M9K flagella biosynthesis protein FliZ D3790_09245 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3790_09250 ENOG4105I03 Flagellin D3790_09255 ENOG4105DTS flagellar hook-associated D3790_09260 ENOG4105MQ3 flagellar protein FliS D3790_09265 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) D3790_09280 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D3790_09285 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D3790_09290 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D3790_09295 ENOG41090PJ Flagellar assembly protein D3790_09300 ENOG4108JIR Flagellum-specific ATP synthase D3790_09305 ENOG4105GSA Flagellar export protein flij D3790_09310 ENOG4105WF4 Flagellar hook-length control protein D3790_09315 ENOG4107ZI8 flagellar basal body-associated protein flil D3790_09320 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D3790_09325 ENOG4105DD5 Flagellar motor switch protein D3790_09335 ENOG4105CN7 Flagellar biosynthetic protein FliP D3790_09340 ENOG4105VS8 Flagellar biosynthetic protein fliq D3790_09345 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D3790_09350 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) D3790_09390 ENOG41066YJ Beta-lactamase D3790_09395 ENOG4105C0W non-ribosomal peptide synthetase D3790_09415 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3790_09440 ENOG4105C3J Cysteine desulfurase D3790_09445 ENOG4107QVI Methyltransferase, type 11 D3790_09450 ENOG4105DTJ flagellar hook-associated protein D3790_09455 ENOG4105E1Q flagellar hook-associated protein D3790_09460 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D3790_09465 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D3790_09470 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D3790_09475 ENOG4105CGA flagellar basal-body rod protein FlgG D3790_09480 ENOG4108KPB Flagellar basal-body rod protein FlgF D3790_09485 ENOG4105BZE flagellar hook protein, FlgE D3790_09490 ENOG4105W00 Flagellar hook capping protein D3790_09495 ENOG4108ZC9 flagellar basal-body rod protein flgc D3790_09500 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D3790_09505 ENOG4105CKS Flagella basal body P-ring formation protein flgA D3790_09510 ENOG4105M9M anti-sigma28 factor FlgM D3790_09515 ENOG4105QVD Flagella synthesis protein FlgN D3790_09525 ENOG4105CW0 outer membrane usher protein D3790_09530 ENOG4108VCD Chaperone D3790_09540 ENOG4105D7B Flagellar biosynthesis protein flha D3790_09545 ENOG4105D00 flagellar biosynthetic protein flhB D3790_09610 ENOG4105D5K Hemolysin activator protein D3790_09620 ENOG4105D5K Hemolysin activator protein D3790_09685 ENOG4108RZ1 DNA transformation protein D3790_09690 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) D3790_09705 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) D3790_09710 ENOG4105DAN ATP-dependent protease D3790_09715 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) D3790_09720 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) D3790_09725 ENOG4108Q2G (LipO)protein D3790_09730 ENOG4105DY2 Paraquat-inducible protein b D3790_09735 ENOG4105F1S paraquat-inducible protein a D3790_09740 ENOG4105C5H ABC transporter D3790_09745 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D3790_09750 ENOG4105QVC MOSC domain-containing protein D3790_09755 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) D3790_09760 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D3790_09765 ENOG4105CD8 aminopeptidase N D3790_09770 ENOG4107RH7 Nicotinate phosphoribosyltransferase D3790_09775 ENOG4105C5S asparaginyl-tRNA synthetase D3790_09780 ENOG4105FCK Membrane D3790_09785 ENOG4105CGF Aromatic amino acid aminotransferase D3790_09790 ENOG4105C5X domain protein D3790_09795 ENOG4105EAQ (twin-arginine translocation) pathway signal D3790_09800 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D3790_09810 ENOG4105F0S class B acid phosphatase D3790_09815 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) D3790_09820 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) D3790_09825 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) D3790_09830 ENOG4106371 Methyltransferase D3790_09835 ENOG4107S90 membrAne D3790_09840 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D3790_09845 ENOG4105W49 UPF0434 protein D3790_09850 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D3790_09855 ENOG4105BZ1 (ABC) transporter D3790_09860 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 D3790_09870 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D3790_09875 ENOG4105CAT Cytidine monophosphate kinase D3790_09880 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D3790_09885 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D3790_09895 ENOG4105HDK L-asparaginase D3790_09900 ENOG4105DDY UPF0142 protein ycaO D3790_09905 ENOG4105TMB Formate nitrite transporter D3790_09910 ENOG4105C6N Formate acetyltransferase D3790_09915 ENOG4105F1A Pyruvate formate-lyase D3790_09935 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D3790_09940 ENOG4105D1H recombination factor protein RarA D3790_09945 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) D3790_09950 ENOG4105CNU cell division protein FtsK D3790_09955 ENOG4105EW9 transcriptional regulator AsnC family D3790_09960 ENOG4105C3M thioredoxin reductase D3790_09965 ENOG4108JJ9 ABC, transporter D3790_09970 ENOG4108JJ8 (ABC) transporter D3790_09975 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) D3790_09980 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D3790_09985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3790_09990 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D3790_09995 ENOG4105VEQ Cold shock protein D3790_10000 ENOG4105CPB ATP-dependent endonuclease of the OLD family D3790_10005 ENOG4105DWU Membrane D3790_10010 ENOG4105E5Z arginine transporter ATP-binding subunit D3790_10015 ENOG4106PMH Extracellular solute-binding protein family 3 D3790_10020 ENOG4105GBT ABC transporter D3790_10025 ENOG4105DMR ABC, transporter D3790_10030 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) D3790_10035 ENOG4108RMJ sensory transduction regulator D3790_10045 ENOG41090BQ Glutaredoxin D3790_10050 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D3790_10055 ENOG4105C44 Serine transporter D3790_10060 ENOG4105DZ1 carboxypeptidase D3790_10065 ENOG4108TGY Glutathione S-transferase D3790_10070 ENOG4108535 NAD dependent epimerase/dehydratase family D3790_10080 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D3790_10085 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D3790_10090 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D3790_10095 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D3790_10100 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D3790_10105 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D3790_10110 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D3790_10115 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D3790_10135 ENOG4105C0A alcohol dehydrogenase D3790_10140 ENOG4108KXH Ybak prolyl-tRNA synthetase associated D3790_10145 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D3790_10150 ENOG4105EE5 Membrane protein terC D3790_10155 ENOG4108X9F tail fiber protein D3790_10160 ENOG4108GAE asmA family D3790_10165 ENOG4105DHP deoxycytidine triphosphate deaminase D3790_10170 ENOG4105DBI uridine monophosphokinase D3790_10175 ENOG4105D1F ATP-binding protein D3790_10180 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D3790_10185 ENOG4105VAW lrga family D3790_10190 ENOG41067MG lrgb family D3790_10195 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) D3790_10200 ENOG4107R1I NAD-dependent malic enzyme D3790_10205 ENOG4107GZ4 SanA protein D3790_10210 ENOG4105DHF Membrane D3790_10215 ENOG4105EUJ GTP cyclohydrolase i D3790_10220 ENOG4105CBP Major Facilitator D3790_10225 ENOG4105CVM Molybdenum cofactor synthesis domain protein D3790_10230 ENOG4105D06 uba thif-type nad fad binding protein D3790_10235 ENOG4105C5H ABC transporter D3790_10240 ENOG4108YM7 Gcn5-related n-acetyltransferase D3790_10245 ENOG4108URH decarboxylase D3790_10250 ENOG4107AQZ Membrane D3790_10260 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D3790_10270 ENOG4105DVT helicase D3790_10275 ENOG4105KHC sulfurtransferase D3790_10285 ENOG410600T transposase D3790_10290 ENOG4107XU6 Glycosyl transferase (Group 1 D3790_10315 ENOG4108X9F tail fiber protein D3790_10340 ENOG4105UZW Tail fiber assembly protein D3790_10395 ENOG4105VZ1 Replication Protein D3790_10410 ENOG4108YYQ gCN5-related N-acetyltransferase D3790_10420 ENOG4108KB1 transcriptional regulator, arac family D3790_10425 ENOG4105WPN DNA integration recombination invertion protein D3790_10430 ENOG4105CHR reductase D3790_10435 ENOG4105CEY Amp-dependent synthetase and ligase D3790_10450 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) D3790_10455 ENOG4108TGR phosphatase D3790_10460 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) D3790_10465 ENOG4108YZT Adenosylcobinamide kinase D3790_10470 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D3790_10480 ENOG4108V4M Cobalt abc transporter D3790_10485 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) D3790_10490 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) D3790_10495 ENOG4105DVK Precorrin-2 c20-methyltransferase D3790_10500 ENOG4107PPM cobalt chelatase D3790_10505 ENOG4105QUC reductase D3790_10510 ENOG4105E4R Precorrin-3B C17-methyltransferase D3790_10515 ENOG4108P62 biosynthesis protein (CbiG) D3790_10520 ENOG4105CIA precorrin-4 C(11)-methyltransferase D3790_10525 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase D3790_10530 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase D3790_10535 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) D3790_10540 ENOG41081F0 Precorrin-8x methylmutase D3790_10545 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) D3790_10550 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D3790_10555 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D3790_10560 ENOG4107QZB decarboxylase D3790_10565 ENOG4105JZC GHMP kinase D3790_10585 ENOG4105DD7 kinase (PfkB family D3790_10600 ENOG4105CRK lysyL-tRNA synthetase D3790_10610 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D3790_10615 ENOG4105T95 Thiol disulfide interChange protein D3790_10620 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3790_10625 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) D3790_10635 ENOG4105Y75 tpr repeat protein D3790_10640 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) D3790_10670 ENOG4105K64 Glycosyl transferase, family 2 D3790_10690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3790_10695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3790_10710 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D3790_10715 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D3790_10720 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D3790_10725 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D3790_10730 ENOG4105D0A hydroxylase D3790_10735 ENOG4107RAQ aminopeptidase D3790_10740 ENOG4105E07 UPF0149 protein D3790_10745 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) D3790_10755 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D3790_10760 ENOG4108JQ1 Dehydrogenase D3790_10770 ENOG4105E66 phosphoriboisomerase A D3790_10775 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) D3790_10780 ENOG4105MPN Membrane D3790_10785 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D3790_10790 ENOG4105D64 Mechanosensitive ion channel D3790_10795 ENOG4108ZIG UPF0231 protein D3790_10800 ENOG4107QIJ Aconitate hydratase 2 D3790_10820 ENOG4105CNA YD repeat protein D3790_10835 ENOG4105C6T cysteine synthase D3790_10840 ENOG4107QN2 dihydrolipoyl dehydrogenase D3790_10845 ENOG4107QSN dihydrolipoamide acetyltransferase D3790_10850 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D3790_10855 ENOG41073TP transcriptional regulator D3790_10860 ENOG4106A72 regulatory protein AmpE D3790_10865 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D3790_10870 ENOG4108ZUW Major pilin subunit D3790_10875 ENOG4107QHF type ii secretion system protein e D3790_10880 ENOG4105D7Q type ii secretion system D3790_10885 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D3790_10890 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) D3790_10895 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) D3790_10900 ENOG4105M6F mutator MutT protein D3790_10905 ENOG4105C5H ABC transporter D3790_10910 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D3790_10915 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) D3790_10925 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3790_10930 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D3790_10935 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D3790_10940 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D3790_10945 ENOG4105CPF Cell wall formation (By similarity) D3790_10950 ENOG4105DFU Cell wall formation (By similarity) D3790_10955 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D3790_10960 ENOG4105CNI cell division protein FtsW D3790_10965 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D3790_10970 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D3790_10975 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) D3790_10980 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D3790_10985 ENOG4105CJN penicillin-binding protein D3790_10990 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D3790_10995 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D3790_11000 ENOG4108V6E Cell division protein mraZ D3790_11005 ENOG4107B7Y DNA-binding transcriptional regulator FruR D3790_11010 ENOG4108ZP8 Acetolactate synthase small subunit D3790_11015 ENOG4105C7K acetolactate synthase D3790_11020 ENOG4108IQE Amp-dependent synthetase and ligase D3790_11025 ENOG41064T2 transcriptional regulator, lysR family D3790_11040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D3790_11045 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) D3790_11055 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D3790_11065 ENOG4105C28 cystathionine D3790_11105 ENOG4108TSE Transferase D3790_11110 ENOG4105CYW agmatinase D3790_11115 ENOG4108X9F tail fiber protein D3790_11120 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) D3790_11125 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D3790_11170 ENOG4105D5G Transposase D3790_11215 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D3790_11220 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D3790_11225 ENOG4105CTB Polyprenyl synthetase D3790_11230 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D3790_11235 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D3790_11240 ENOG4107S0N DJ-1 family D3790_11245 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D3790_11250 ENOG4108VPT UPF0234 protein D3790_11255 ENOG4107RDB Major Facilitator D3790_11260 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D3790_11265 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D3790_11270 ENOG4105CCU oxidase (Subunit III) D3790_11275 ENOG4105BZ9 Cytochrome C oxidase, subunit I D3790_11280 ENOG4105E2S oxidase) subunit II D3790_11285 ENOG4108NFH Sugar hydrolase D3790_11290 ENOG4105EYM Major Facilitator superfamily D3790_11295 ENOG4105IEY (LipO)protein D3790_11300 ENOG4105M85 Bola protein D3790_11305 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D3790_11310 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D3790_11315 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D3790_11325 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D3790_11335 ENOG4105K70 DNA-binding protein D3790_11340 ENOG4105EIN peptidylprolyl cis-trans isomerase D3790_11345 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein D3790_11350 ENOG4108TGP Thioesterase superfamily protein D3790_11355 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D3790_11365 ENOG4108XM1 transcriptional regulator AsnC family D3790_11370 ENOG4105BZ1 (ABC) transporter D3790_11375 ENOG4105BZ1 (ABC) transporter D3790_11380 ENOG4108YZA Nitrogen regulatory protein pii D3790_11385 ENOG4105BZU Histidine kinase D3790_11390 ENOG4105C29 acyl-CoA thioesterase D3790_11400 ENOG4105KF5 hemolysin expression-modulating protein D3790_11405 ENOG4108UKR Biofilm formation regulator YbaJ D3790_11420 ENOG4105BZS acriflavin resistance protein D3790_11425 ENOG4105C1P efflux transporter, rnd family, mfp subunit D3790_11430 ENOG4108IG5 Transcriptional regulator D3790_11435 ENOG41090EX DsrE family D3790_11440 ENOG4105EGS Mechanosensitive ion channel D3790_11445 ENOG4106428 Protein of unknown function (DUF2496) D3790_11455 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D3790_11460 ENOG4107QMP dna polymerase iii subunits gamma and tau D3790_11465 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D3790_11470 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D3790_11475 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D3790_11480 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D3790_11485 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D3790_11490 ENOG4108QY5 Ferric enterobactin transport protein D3790_11495 ENOG4107RE1 Inosine-guanosine kinase D3790_11500 ENOG4105CKD glutathione-regulated potassium-efflux system protein D3790_11505 ENOG4105EU0 Major facilitator Superfamily D3790_11510 ENOG4105CGH 5'-nucleotidase D3790_11520 ENOG4108Z66 YbaK ebsC protein D3790_11525 ENOG4105MBR gumn family D3790_11530 ENOG4105C59 p-type ATPase D3790_11535 ENOG4108Z6Z Transcriptional regulator D3790_11540 ENOG4105G5H Membrane D3790_11545 ENOG4107QX8 SPFH domain, Band 7 family protein D3790_11550 ENOG4107QR8 Thioredoxin D3790_11555 ENOG4105E1F short-chain dehydrogenase reductase D3790_11560 ENOG4108UJV acyl-CoA thioesterase i D3790_11565 ENOG4108I0Y (ABC) transporter D3790_11570 ENOG4105CV6 ABC transporter, permease D3790_11585 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D3790_11590 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D3790_11595 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) D3790_11600 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D3790_11605 ENOG4105C8N cysteinyl-tRNA synthetase D3790_11635 ENOG4108ZRK uncharacterized protein yacC D3790_11640 ENOG4108UGV hypoxanthine phosphoribosyltransferase D3790_11645 ENOG41077A9 carbonic anhydrase D3790_11650 ENOG4105DA5 (ABC) transporter D3790_11655 ENOG4105E3A (ABC) transporter D3790_11675 ENOG4105CV8 reductase D3790_11680 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D3790_11685 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D3790_11690 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D3790_11695 ENOG4105DJ0 Poly(A) Polymerase D3790_11700 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) D3790_11705 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D3790_11710 ENOG4105PW4 Sugar fermentation stimulation protein homolog D3790_11715 ENOG4105CQ7 ATP-dependent helicase D3790_11720 ENOG4105BZ4 penicillin-binding protein D3790_11725 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D3790_11730 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D3790_11745 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D3790_11750 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D3790_11755 ENOG4105BZU Histidine kinase D3790_11760 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D3790_11765 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D3790_11770 ENOG4105DXN mazG family D3790_11780 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D3790_11785 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D3790_11790 ENOG4105C8P )-transporter D3790_11800 ENOG4105C26 Dehydrogenase D3790_11805 ENOG4105CK2 sodium dicarboxylate symporter D3790_11820 ENOG410600T transposase D3790_11825 ENOG4105DNE Transposase D3790_11870 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D3790_11875 ENOG4108ZAI phosphatidylglycerophosphatase a D3790_11880 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D3790_11885 ENOG4107YIM Involved in the transcription termination process (By similarity) D3790_11890 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D3790_11895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D3790_11900 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D3790_11905 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D3790_11915 ENOG4105VIE preprotein translocase, subunit YajC D3790_11925 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D3790_11930 ENOG4108ZYK Acyl carrier protein phosphodiesterase D3790_11935 ENOG4105D3R alkyl hydroperoxide reductase D3790_11950 ENOG4105CWM branched-chain amino acid transport system II carrier protein D3790_11960 ENOG4105BZU Histidine kinase D3790_11965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3790_11970 ENOG4107RH8 nuclease SbcCD subunit D D3790_11975 ENOG4105EYH Exonuclease D3790_11980 ENOG4105C8J )-transporter D3790_11985 ENOG4107QSI ABC, transporter D3790_11990 ENOG4107QSI ABC, transporter D3790_12005 ENOG41083KI ribonuclease, T2 D3790_12030 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D3790_12065 ENOG4105CHU acetyl-coa acetyltransferase D3790_12085 ENOG4106YSC D3790_12090 ENOG4105XB7 anti-repressor protein D3790_12105 ENOG4105DFP Integrase D3790_12125 ENOG4107UWN reductase D3790_12130 ENOG4105EFA 4-hydroxyphenylacetate D3790_12140 ENOG41063TF transcriptional regulator (AraC D3790_12150 ENOG4105CNV Aldolase D3790_12160 ENOG4105C26 Dehydrogenase D3790_12170 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase D3790_12175 ENOG4105C26 Dehydrogenase D3790_12185 ENOG4105ERH Fumarylacetoacetate hydrolase D3790_12190 ENOG4108V8F Transcriptional regulator, MarR family D3790_12200 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_12290 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D3790_12325 ENOG4105D1U peptidase U62 modulator of DNA gyrase D3790_12335 ENOG4105QD6 exported protein D3790_12340 ENOG4105C03 ribonuclease D3790_12345 ENOG4108Z03 MAF-like protein D3790_12350 ENOG4105VQ7 Rod shape-determining protein MreD D3790_12355 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D3790_12360 ENOG4105DFF Rod shape-determining protein mreb D3790_12365 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D3790_12370 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D3790_12375 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D3790_12380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D3790_12385 ENOG4105RG0 Membrane D3790_12390 ENOG4108IA2 Sodium pantothenate symporter D3790_12395 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3790_12405 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) D3790_12410 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_12470 ENOG4105CHR reductase D3790_12475 ENOG4108IPJ Membrane D3790_12500 ENOG4105CIH Imidazole acetol-phosphate transaminase D3790_12535 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D3790_12540 ENOG4105CFG Acts as a chaperone (By similarity) D3790_12545 ENOG4106HK8 GPR1 FUN34 yaaH family protein D3790_12555 ENOG4108RIR Molybdenum cofactor biosynthesis protein D3790_12560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D3790_12565 ENOG4105D1Q UPF0246 protein D3790_12595 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D3790_12600 ENOG4105WQI isochorismatase D3790_12610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D3790_12615 ENOG4105C2C drug resistance transporter, Bcr CflA D3790_12625 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D3790_12635 ENOG41065U4 response regulator D3790_12645 ENOG4108RH0 Crea protein D3790_12650 ENOG4105UEI Transcriptional Regulator AraC Family D3790_12655 ENOG4105CVJ phosphoglycerate mutase D3790_12660 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D3790_12665 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) D3790_12670 ENOG4107SC1 transglycosylase D3790_12680 ENOG4105C5H ABC transporter D3790_12690 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase D3790_12710 ENOG4108IV0 ABC, transporter D3790_12715 ENOG4105C0Z ABC transporter D3790_12720 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3790_12725 ENOG4105C32 Amino acid ABC transporter (Permease) D3790_12730 ENOG4105CP9 extracellular ligand-binding receptor D3790_12740 ENOG4105BZW Glycerate kinase D3790_12750 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3790_12755 ENOG4105CRP Part of the ABC transporter FtsEX involved in D3790_12760 ENOG4105CAK Cell division ATP-binding protein ftsE D3790_12765 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D3790_12770 ENOG4106H78 methyltransferase D3790_12775 ENOG4105MG3 Membrane D3790_12780 ENOG4107FS9 Membrane D3790_12790 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D3790_12795 ENOG4105EX9 Membrane D3790_12825 ENOG4105CXY transporter D3790_12830 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase D3790_12835 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) D3790_12855 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D3790_12860 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D3790_12865 ENOG4107ENK receptor D3790_12870 ENOG4108JIK carboxylase D3790_12880 ENOG4105E7W lamb ycsf family protein D3790_12920 ENOG4105DC1 bifunctional purine biosynthesis protein purh D3790_12925 ENOG4105C12 Phosphoribosylglycinamide synthetase D3790_12930 ENOG4108T8B Protein of unknown function (DUF1481) D3790_12935 ENOG4105K70 DNA-binding protein D3790_12940 ENOG4105R2J Conserved Protein D3790_12945 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) D3790_12950 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D3790_12955 ENOG4105DGW oligopeptidase A D3790_12960 ENOG4105E09 nadh pyrophosphatase D3790_12985 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D3790_12990 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D3790_12995 ENOG4105D06 uba thif-type nad fad binding protein D3790_13000 ENOG4105WHD thiamine biosynthesis protein ThiS D3790_13005 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D3790_13010 ENOG4105D41 biosynthesis protein thiH D3790_13025 ENOG4108YXQ IS66 Orf2 family protein D3790_13030 ENOG4105E5H Transposase D3790_13035 ENOG4108EX3 reductase D3790_13045 ENOG4105EAB amino acid AbC transporter D3790_13050 ENOG4105DRP amino acid AbC transporter D3790_13055 ENOG4105CDA abc transporter atp-binding protein D3790_13060 ENOG4105EAB amino acid AbC transporter D3790_13080 ENOG4105E3J oxidoreductase D3790_13095 ENOG4105C26 Dehydrogenase D3790_13100 ENOG4105DVW rieske (2Fe-2S) D3790_13105 ENOG4105C94 Transporter D3790_13115 ENOG4105EJC lysr family transcriptional regulator D3790_13140 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) D3790_13145 ENOG4105DBV ornithine carbamoyltransferase D3790_13160 ENOG4105K6H D-cysteine desulfhydrase D3790_13165 ENOG4105K6H D-cysteine desulfhydrase D3790_13170 ENOG410829K Lysine exporter protein (Lyse ygga) D3790_13175 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) D3790_13185 ENOG4105MRR Transcriptional regulator (By similarity) D3790_13190 ENOG4105E0Y RtcB Protein D3790_13235 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit D3790_13255 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) D3790_13260 ENOG4105KME endoribonuclease L-psp D3790_13270 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase D3790_13275 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) D3790_13280 ENOG4108ZPB UPF0306 protein D3790_13295 ENOG4108YYD acetyltransferase D3790_13300 ENOG4105XPQ lipid carrier protein D3790_13305 ENOG4105TNG K13735 adhesin invasin D3790_13310 ENOG4108HRK Histidine kinase D3790_13315 ENOG4108NEV two component transcriptional regulator, LytTR family D3790_13320 ENOG4105C1J atp-dependent rna helicase D3790_13330 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D3790_13335 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D3790_13340 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D3790_13345 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D3790_13350 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D3790_13355 ENOG4105CHV Transcription elongation factor NusA D3790_13360 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D3790_13380 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D3790_13385 ENOG4105EEI dihydropteroate synthase D3790_13390 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D3790_13395 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D3790_13400 ENOG4105HBR Rna-binding protein D3790_13405 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D3790_13410 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D3790_13415 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D3790_13420 ENOG4105K46 50S ribosomal protein l27 D3790_13425 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D3790_13430 ENOG4105EAH synthase D3790_13445 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_13450 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D3790_13460 ENOG4105DFU Cell wall formation (By similarity) D3790_13465 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D3790_13470 ENOG4105F0N pyrophosphate phospho-hydrolase D3790_13475 ENOG4108ZHD aig2 family D3790_13485 ENOG4105CFU surface antigen D3790_13490 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D3790_13495 ENOG4105C37 (CBS) domain D3790_13500 ENOG41061GZ Protein of unknown function (DUF1107) D3790_13505 ENOG4108UUE Transcriptional regulator D3790_13510 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase D3790_13515 ENOG4105MZG transcriptional modulator of maze toxin, mazf D3790_13525 ENOG4108V1T peptidylprolyl cis-trans isomerase D3790_13545 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D3790_13550 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D3790_13555 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) D3790_13560 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D3790_13565 ENOG4105C2N RNA methyltransferase TrmH family group 3 D3790_13570 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D3790_13575 ENOG4105KPV Transcriptional regulator D3790_13580 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D3790_13585 ENOG4105EPW hflc protein D3790_13590 ENOG4107QJR hflk protein D3790_13595 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D3790_13600 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D3790_13605 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D3790_13610 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D3790_13615 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3790_13620 ENOG4105K8N protein family UPF0079, ATPase D3790_13625 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D3790_13630 ENOG4105EFA 4-hydroxyphenylacetate D3790_13635 ENOG4105EFA 4-hydroxyphenylacetate D3790_13640 ENOG4108KC1 acyl-Coa dehydrogenase D3790_13645 ENOG4105C0F tryptophanase EC 4.1.99.1 D3790_13655 ENOG4105C57 major facilitator superfamily D3790_13660 ENOG4105CBN LysR family transcriptional regulator D3790_13690 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) D3790_13695 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D3790_13700 ENOG4105DJ4 phosphatidylserine decarboxylase D3790_13705 ENOG4105EGS Mechanosensitive ion channel D3790_13720 ENOG4105KAF membrAne D3790_13725 ENOG4105ETE Transcriptional regulator (LacI family D3790_13735 ENOG4105DQF Hydrolase D3790_13740 ENOG4108EUD Lysophospholipase D3790_13745 ENOG4105C9U ATP-dependent DNA helicase RecQ D3790_13755 ENOG4108VUY thioesterase Superfamily protein D3790_13765 ENOG4105FR1 rard protein D3790_13780 ENOG4107QUT magnesium and cobalt transport protein CorA D3790_13785 ENOG4105C4R Atp-dependent dna helicase D3790_13790 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant D3790_13795 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3790_13800 ENOG4105CT0 Protein of unknown function, DUF484 D3790_13805 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D3790_13810 ENOG4105S7Z (LipO)protein D3790_13815 ENOG4105XQ6 frataxin-like protein D3790_13820 ENOG4107T0K Adenylate cyclase D3790_13825 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D3790_13830 ENOG41076E6 Uroporphyrinogen-III Synthase D3790_13835 ENOG4105ECF c-methyltransferase D3790_13840 ENOG410601J HemY protein D3790_13865 ENOG4105C85 amino acid D3790_13870 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family D3790_13875 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) D3790_13880 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) D3790_13885 ENOG4105EGZ biosynthesis protein D3790_13890 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3790_13895 ENOG4108WJ1 acetyltransferase D3790_13900 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D3790_13905 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3790_13910 ENOG4108IJ1 Dehydrogenase D3790_13915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D3790_13920 ENOG4105SFE lipopolysaccharide biosynthesis protein D3790_13925 ENOG4105ESV Glycosyl transferase, family 4 D3790_13940 ENOG4105K63 Thioredoxin D3790_13945 ENOG4105C1J atp-dependent rna helicase D3790_13950 ENOG4105C9X ppx gppa phosphatase D3790_13955 ENOG4105C4R Atp-dependent dna helicase D3790_13960 ENOG4105DGU Histone deacetylase D3790_13965 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D3790_13970 ENOG4105EMY transcriptional regulator D3790_13985 ENOG4105C7B Threonine dehydratase D3790_13990 ENOG4105C01 Dihydroxy-acid dehydratase D3790_13995 ENOG4105CM2 brancheD-chain amino acid aminotransferase D3790_14000 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit D3790_14015 ENOG4105C0P Mg chelatase subunit ChlI D3790_14020 ENOG4108WFC UPF0438 protein yifE D3790_14025 ENOG4105CVI Transcriptional regulator D3790_14065 ENOG4108Z0R Transferase D3790_14070 ENOG4105SG3 Protein of unknown function (DUF1488) D3790_14075 ENOG4105E2X shikimate dehydrogenase D3790_14080 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3790_14085 ENOG4108WI1 Dna topoisomerase D3790_14090 ENOG4105C79 DNA protecting protein DprA D3790_14095 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D3790_14100 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D3790_14105 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D3790_14110 ENOG4105C1A potassium transporter peripheral membrane D3790_14115 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system D3790_14120 ENOG4105W1Y Transcriptional regulator D3790_14125 ENOG4108ZT0 50S ribosomal protein l17 D3790_14130 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3790_14135 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D3790_14140 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D3790_14145 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D3790_14150 ENOG41067V7 50S ribosomal protein L36 D3790_14155 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D3790_14160 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D3790_14165 ENOG4105VPB 50S ribosomal protein L30 D3790_14170 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D3790_14175 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D3790_14180 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D3790_14185 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D3790_14190 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D3790_14195 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D3790_14200 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D3790_14205 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D3790_14210 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D3790_14215 ENOG41083MP 50s ribosomal protein l29 D3790_14220 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D3790_14225 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D3790_14230 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D3790_14235 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D3790_14240 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D3790_14250 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D3790_14255 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D3790_14265 ENOG410600T transposase D3790_14285 ENOG4105EKQ RNA-directed DNA polymerase D3790_14310 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D3790_14345 ENOG4105CS9 pantothenic acid kinase D3790_14350 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D3790_14355 ENOG4105D4A Cell wall formation (By similarity) D3790_14390 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D3790_14395 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D3790_14400 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) D3790_14405 ENOG4108Y73 Membrane D3790_14415 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) D3790_14420 ENOG4105C5Q Transcriptional regulator D3790_14425 ENOG4105CH7 arginosuccinase D3790_14430 ENOG4105CDH Citrulline--aspartate ligase D3790_14440 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D3790_14445 ENOG4105CWC Acetylornithine deacetylase D3790_14450 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin D3790_14465 ENOG41063XI Toxic component of a toxin-antitoxin (TA) module. A D3790_14470 ENOG4105SYT Methylenetetrahydrofolate reductase D3790_14475 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression D3790_14490 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) D3790_14495 ENOG4105CFH Aspartokinase D3790_14500 ENOG4105C28 cystathionine D3790_14505 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) D3790_14515 ENOG4105C25 Primosomal protein n' D3790_14520 ENOG4105ETE Transcriptional regulator (LacI family D3790_14525 ENOG41063M6 Cell Division Protein D3790_14530 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D3790_14535 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D3790_14540 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D3790_14545 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D3790_14550 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) D3790_14560 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D3790_14565 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D3790_14570 ENOG4105E5M Multidrug resistance protein D D3790_14575 ENOG4105DP0 ferredoxin-NADP reductase D3790_14580 ENOG4108VTS Membrane D3790_14585 ENOG4105EBK exported protein D3790_14590 ENOG4105CP7 Triose-phosphate isomerase D3790_14615 ENOG41060M8 Pfam:PhdYeFM D3790_14630 ENOG4105F5P DNA-damage-inducible protein d D3790_14695 ENOG4105DSJ YicC domain protein D3790_14700 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D3790_14705 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D3790_14710 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D3790_14715 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D3790_14720 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D3790_14725 ENOG4105W5Q DNA repair protein (RadC D3790_14740 ENOG4105W0E 50S ribosomal protein L33 D3790_14745 ENOG4105CPK Glycosyl transferase (Group 1 D3790_14750 ENOG4105XA0 heptosyltransferase ii D3790_14755 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3790_14765 ENOG4108FRV O-antigen ligase D3790_14770 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D3790_14775 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D3790_14785 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D3790_14790 ENOG4105DKP glycosyl transferase, family 9 D3790_14800 ENOG4105CPK Glycosyl transferase (Group 1 D3790_14820 ENOG4105D16 lipopolysaccharide heptosyltransferase i D3790_14825 ENOG4105XA0 heptosyltransferase ii D3790_14830 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D3790_14835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3790_14840 ENOG4105CPQ Dehydrogenase D3790_14845 ENOG4105PXI polysaccharide deacetylase D3790_14850 ENOG41063SB peptidase D3790_14860 ENOG4105VUH addiction module killer protein D3790_14865 ENOG4107YZP Rhodanese domain protein D3790_14870 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D3790_14875 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D3790_14880 ENOG4105D7W serine acetyltransferase D3790_14885 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D3790_14940 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3790_14945 ENOG4105D3Q Sugar transferase D3790_14975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D3790_15005 ENOG4108REZ Imidazole glycerol phosphate synthase D3790_15010 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D3790_15045 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3790_15050 ENOG4105J5G Transferase hexapeptide repeat containing protein D3790_15055 ENOG4105D9R oxidoreductase D3790_15060 ENOG4107QQG Dehydrogenase D3790_15065 ENOG4105E0F Histidine kinase D3790_15070 ENOG4105E3W Two component transcriptional regulator (Winged helix family D3790_15075 ENOG4105FMW periplasmic D3790_15085 ENOG41063XI Toxic component of a toxin-antitoxin (TA) module. A D3790_15090 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin D3790_15105 ENOG4105MVF Transcriptional regulator D3790_15120 ENOG41076HS cation diffusion facilitator family transporter D3790_15125 ENOG4105CTQ phosphohexokinase D3790_15130 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D3790_15135 ENOG4107R3N Filamentation induced by cAMP protein fic D3790_15150 ENOG4105X54 addiction module antidote protein D3790_15155 ENOG4108TFM Kinase, PfkB family D3790_15165 ENOG4105FDP GntR family transcriptional regulator D3790_15170 ENOG4107T7U Sulfatase D3790_15175 ENOG4105EM7 Selenocysteine-specific translation elongation factor D3790_15175 ENOG4105EM7 Selenocysteine-specific translation elongation factor D3790_15180 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) D3790_15195 ENOG4105PPN plasmid maintenance protein, CcdB D3790_15205 ENOG4108MG3 formate dehydrogenase D3790_15210 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D3790_15215 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D3790_15240 ENOG4108DNJ Pfam:TonB D3790_15245 ENOG4105DYS nad(p)h dehydrogenase (quinone) D3790_15260 ENOG4108JQC penicillin-binding protein 1A D3790_15280 ENOG4105E4G Type IV pilus D3790_15290 ENOG4105D49 3-dehydroquinate synthase D3790_15295 ENOG4105EGB membrane protein DamX D3790_15305 ENOG4105DJV ribulose-phosphate 3-epimerase D3790_15310 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D3790_15315 ENOG4105C31 Tryptophanyl-tRNA synthetase D3790_15320 ENOG4108RPX mosc domain containing protein D3790_15330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D3790_15335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3790_15340 ENOG41062QD Membrane D3790_15345 ENOG4107QN1 sodium solute D3790_15375 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3790_15380 ENOG4105ETE Transcriptional regulator (LacI family D3790_15385 ENOG4108RVA ribokinase D3790_15400 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) D3790_15405 ENOG4105EV2 VWA domain protein interacting with AAA ATPase D3790_15410 ENOG4105CU9 asparagine synthetase A D3790_15415 ENOG4108VVK transcriptional Regulator, AsnC D3790_15420 ENOG4105QTB Flavodoxin D3790_15425 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D3790_15430 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D3790_15435 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation D3790_15440 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) D3790_15445 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3790_15450 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3790_15455 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3790_15460 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D3790_15465 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D3790_15470 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D3790_15475 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D3790_15480 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D3790_15485 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D3790_15495 ENOG4105EKX Restriction modification system DNA (Specificity D3790_15500 ENOG4105DZR Type I site-specific deoxyribonuclease D3790_15525 ENOG4105NRA 50s ribosomal protein l31 type b D3790_15530 ENOG4105NRA 50s ribosomal protein l31 type b D3790_15535 ENOG4105YK5 50S ribosomal protein L36 D3790_15540 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D3790_15560 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3790_15565 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D3790_15570 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D3790_15580 ENOG4105VG0 50S ribosomal protein l34 D3790_15585 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D3790_15590 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D3790_15595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D3790_15600 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D3790_15605 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D3790_15630 ENOG4105DS1 cytochrome b561 D3790_15635 ENOG4108YYC ycei family D3790_15655 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A D3790_15660 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein D3790_15675 ENOG4105DZS Phenylacetate-CoA ligase D3790_15680 ENOG4105CHU acetyl-coa acetyltransferase D3790_15685 ENOG4108ZJI phenylacetic acid degradation protein D3790_15690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3790_15695 ENOG4108UKI Enoyl-CoA hydratase D3790_15700 ENOG4105E39 Enoyl-CoA hydratase D3790_15705 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D3790_15710 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit D3790_15715 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit D3790_15720 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit D3790_15725 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit D3790_15730 ENOG4105DXM phenylacetic acid degradation protein D3790_15735 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) D3790_15740 ENOG4108Z3N Transcriptional regulator D3790_15755 ENOG4108V6B universal stress protein B D3790_15760 ENOG4105CJ3 phosphate transporter D3790_15765 ENOG4105CBX hi0933 family D3790_15800 ENOG4105C2I pirin domain protein D3790_15805 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D3790_15810 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D3790_15815 ENOG4105VEJ Heat shock protein D3790_15820 ENOG4105DQY intracellular growth attenuator D3790_15825 ENOG4107RK2 ADP-ribose diphosphatase NudE D3790_15835 ENOG4105C5Y PTS System D3790_15840 ENOG4105CG3 alpha amylase, catalytic region D3790_15885 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D3790_15955 ENOG4105VSH 4-oxalocrotonate tautomerase D3790_15960 ENOG4107H3J ribonuclease D3790_15975 ENOG4108WC9 type VI secretion system effector, hcp1 family D3790_16025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3790_16085 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_16150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3790_16165 ENOG4105D4P Coproporphyrinogen iii oxidase D3790_16175 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) D3790_16220 ENOG4105GMB type VI secretion system effector, hcp1 family D3790_16225 ENOG4105E5Q amino acid AbC transporter D3790_16230 ENOG4105EAD ABC transporter D3790_16235 ENOG4105CT1 (ABC) transporter D3790_16240 ENOG4108UTW Plays a role in the regulation of phosphate uptake D3790_16245 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D3790_16250 ENOG4105E2Z phosphate ABC transporter (Permease D3790_16255 ENOG4105C8U phosphate abc transporter D3790_16260 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) D3790_16265 ENOG4105E0F Histidine kinase D3790_16270 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D3790_16275 ENOG4108RRZ Transcription elongation factor GreB D3790_16280 ENOG4105BZM domain protein D3790_16290 ENOG4105XFK Ferrous iron transport protein A D3790_16300 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) D3790_16310 ENOG4105DGW oligopeptidase A D3790_16315 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) D3790_16325 ENOG4108M6U Universal stress protein A D3790_16340 ENOG4106PKC pyridoxal phosphate binding D3790_16345 ENOG4106M0N transport system permease protein D3790_16350 ENOG4105MUZ Protein of unknown function DUF2620 D3790_16355 ENOG41080QX K07048 phosphotriesterase-related protein D3790_16360 ENOG4108626 Racemase D3790_16365 ENOG4105RMW regulation of transcription, DNA-dependent D3790_16370 ENOG4108M21 D3790_16375 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) D3790_16385 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D3790_16390 ENOG4105E98 transcriptional regulator DeoR family D3790_16395 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) D3790_16400 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) D3790_16410 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) D3790_16415 ENOG4105MJ2 Competence protein D3790_16420 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D3790_16440 ENOG4105CS0 peptidase D3790_16445 ENOG4105D7V transposase D3790_16450 ENOG4108RS6 transposase D3790_16455 ENOG4105BZU Histidine kinase D3790_16460 ENOG4108JQ7 (ABC) transporter D3790_16465 ENOG4105C3U ABC transporter D3790_16470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3790_16475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3790_16480 ENOG4105DEF Extracellular solute-binding protein, family 5 D3790_16495 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D3790_16500 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit D3790_16505 ENOG4108R3E Dna-3-methyladenine glycosylase i D3790_16520 ENOG4105C4X radical SAM domain protein D3790_16530 ENOG4105C42 Type I secretion membrane fusion protein (HlyD D3790_16540 ENOG4105R2A (LipO)protein D3790_16545 ENOG4105D99 atp gtp-binding protein D3790_16550 ENOG4105EN6 Membrane D3790_16555 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) D3790_16560 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D3790_16565 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D3790_16570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D3790_16575 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase D3790_16580 ENOG4105CB5 ATP-dependent DNA helicase recG D3790_16585 ENOG4105D6U Sodium Glutamate Symporter D3790_16590 ENOG4105C2W permease D3790_16595 ENOG4105JV1 AsmA family D3790_16600 ENOG4105SUU thioesterase domain D3790_16605 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D3790_16635 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_16665 ENOG4105EKQ RNA-directed DNA polymerase D3790_16725 ENOG4107BJW polysaccharide deacetylase D3790_16730 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3790_16735 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3790_16740 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D3790_16745 ENOG4108VZM 50s ribosomal protein L10 D3790_16750 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D3790_16755 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D3790_16760 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D3790_16765 ENOG4105PM1 preprotein translocase subunit SecE D3790_16770 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D3790_16775 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D3790_16780 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D3790_16785 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D3790_16790 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D3790_16795 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D3790_16800 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) D3790_16805 ENOG4105WWK YheO domain protein D3790_16810 ENOG4108V1T peptidylprolyl cis-trans isomerase D3790_16815 ENOG4105VRX Protein slyX homolog D3790_16830 ENOG4107TK4 histidinol-phosphate phosphatase D3790_16835 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D3790_16840 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3790_16850 ENOG4105IIU Aminopeptidase D3790_16860 ENOG4108YZY peptidylprolyl cis-trans isomerase D3790_16865 ENOG4105VKU nucleicacid-binding protein D3790_16875 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D3790_16880 ENOG4105C5H ABC transporter D3790_16890 ENOG4105DDW LysR family Transcriptional regulator D3790_16900 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D3790_16905 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) D3790_16910 ENOG4108VP3 Lysine exporter protein (LysE YggA) D3790_16915 ENOG4105DNZ Alpha Beta Hydrolase D3790_16920 ENOG4105YP7 UPF0270 protein D3790_16925 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) D3790_16930 ENOG4107RYR Transcriptional regulator, Crp Fnr family D3790_16935 ENOG4105C8Y Acetylornithine aminotransferase D3790_16945 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D3790_16955 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D3790_16960 ENOG4105C2M dna polymerase I D3790_16965 ENOG4108Z33 Thiol disulfide Interchange Protein D3790_16970 ENOG4105E27 serine threonine protein kinase D3790_16980 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b D3790_16985 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound D3790_16990 ENOG41061GT Aldolase D3790_16995 ENOG4105D4B ABC, transporter D3790_17000 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) D3790_17025 ENOG4105D6S protein involved in catabolism of external DNA D3790_17030 ENOG4105DC8 reductase D3790_17115 ENOG4107W52 maltose operon periplasmic protein D3790_17120 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D3790_17125 ENOG4108IJ9 (ABC) transporter D3790_17130 ENOG4107FKK extracellular solute-binding protein family 1 D3790_17135 ENOG4105D56 permease protein D3790_17140 ENOG4105EG2 ABC transporter, permease D3790_17145 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D3790_17150 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D3790_17155 ENOG41061ZR Transcriptional regulator D3790_17160 ENOG4108JPW Aminotransferase D3790_17170 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 D3790_17175 ENOG4106UW1 Major Facilitator superfamily D3790_17190 ENOG4105E5H Transposase D3790_17195 ENOG4108YXQ IS66 Orf2 family protein D3790_17220 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D3790_17225 ENOG4105MYG DNA polymerase iii, chi subunit D3790_17230 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D3790_17235 ENOG4108M8S permease YjgP YjgQ family protein D3790_17240 ENOG4108K5H permease YjgP YjgQ family protein D3790_17245 ENOG4107R6D beta-lactam binding protein AmpH D3790_17265 ENOG4108J1Q D3790_17300 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) D3790_17315 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D3790_17335 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein D3790_17340 ENOG4105CAF HipA N-terminal domain protein D3790_17345 ENOG4105CK2 sodium dicarboxylate symporter D3790_17350 ENOG4107YNJ LysR family Transcriptional regulator D3790_17355 ENOG4105CG9 aspartate racemase D3790_17360 ENOG4108HFV D3790_17400 ENOG4105DZR Type I site-specific deoxyribonuclease D3790_17405 ENOG4105D5G Transposase D3790_17425 ENOG4105N42 UPF0307 protein D3790_17430 ENOG4105CMS peptidase U62, modulator of DNA gyrase D3790_17450 ENOG4105NXH GreA GreB family elongation factor D3790_17480 ENOG4105DND Transcriptional regulator D3790_17485 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) D3790_17490 ENOG41080Z8 PHOSPHOCARRIER protein D3790_17495 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D3790_17500 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D3790_17505 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA D3790_17510 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3790_17515 ENOG4108IUZ ABC transporter D3790_17520 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA D3790_17525 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) D3790_17530 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase D3790_17535 ENOG4105C2X Arabinose 5-phosphate isomerase D3790_17540 ENOG4105FEU K -dependent Na -Ca exchanger D3790_17545 ENOG4105DHJ ABC, transporter D3790_17550 ENOG4105CY3 ABC transporter, permease D3790_17555 ENOG4107PE3 Mammalian cell entry related domain protein D3790_17560 ENOG4105E3I toluene tolerance D3790_17565 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane D3790_17570 ENOG4105VFK BolA family D3790_17575 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D3790_17580 ENOG4105C0H protease D3790_17585 ENOG4105C0H protease D3790_17595 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III D3790_17600 ENOG4105D6Z AFG1 family ATPase D3790_17605 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D3790_17610 ENOG4108UJD 30S ribosomal protein S9 D3790_17615 ENOG4107MKT Stringent starvation protein a D3790_17620 ENOG4105KB2 stringent starvation protein b D3790_17630 ENOG4105BZ8 glutamate synthase D3790_17635 ENOG4105CBC glutamate synthase D3790_17645 ENOG4105BZU Histidine kinase D3790_17650 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain D3790_17655 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D3790_17670 ENOG4105W4M Transport-associated protein D3790_17675 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D3790_17680 ENOG41082RQ UPF0102 protein D3790_17690 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D3790_17705 ENOG4108CNN domain protein D3790_17710 ENOG4105CWB LysR family transcriptional Regulator D3790_17715 ENOG4108VBZ doxx family D3790_17725 ENOG41090KG Inner membrane protein YqjE D3790_17730 ENOG4105NE1 Conserved Protein D3790_17735 ENOG4106W5V Membrane D3790_17740 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) D3790_17745 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D3790_17755 ENOG4108MJ5 VirK protein D3790_17770 ENOG4108ISG Major Facilitator D3790_17845 ENOG4108KU3 Integrase D3790_17875 ENOG410600T transposase D3790_17880 ENOG4108WC9 type VI secretion system effector, hcp1 family D3790_17930 ENOG4105CAR Terminase, large subunit D3790_17940 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_17955 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3790_17960 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D3790_17965 ENOG4105VCC 30S ribosomal protein S21 D3790_17970 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3790_17980 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D3790_17985 ENOG4107ZVW dihydroneopterin aldolase D3790_17995 ENOG4106MWK domain protein D3790_18000 ENOG4105I7R Adenylate cyclase D3790_18005 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D3790_18010 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D3790_18015 ENOG4105W0Z cytoplasmic protein D3790_18020 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D3790_18025 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D3790_18030 ENOG4106032 Glutathionylspermidine synthase D3790_18035 ENOG4105F1G UPF0441 protein D3790_18040 ENOG4105DFG type I secretion outer membrane protein D3790_18045 ENOG41087AY ADP-Ribose pyrophosphatase D3790_18050 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D3790_18055 ENOG4105IPS esterase D3790_18060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3790_18065 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3790_18070 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase D3790_18075 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) D3790_18080 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D3790_18085 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D3790_18090 ENOG4105NWN ApaG protein D3790_18095 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D3790_18100 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D3790_18105 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D3790_18110 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D3790_18115 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) D3790_18120 ENOG4105D3G Pseudouridine synthase D3790_18125 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) D3790_18140 ENOG4107T0D ABC, transporter D3790_18145 ENOG4106SMU thiamine transporter membrane protein D3790_18150 ENOG4105DP9 ABC transporter D3790_18155 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D3790_18160 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase D3790_18165 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D3790_18170 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D3790_18190 ENOG4105IPU prepilin peptidase dependent protein A D3790_18195 ENOG4105JCS prepilin peptidase dependent protein D3790_18210 ENOG4105DSY exodeoxyribonuclease V, gamma D3790_18215 ENOG4107QXK peptidase D3790_18220 ENOG4107QKA exodeoxyribonuclease V beta D3790_18225 ENOG4107QYX exodeoxyribonuclease v alpha D3790_18235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3790_18255 ENOG4105CA3 membrane-bound lytic murein transglycosylase D3790_18260 ENOG4105CUZ uba thif-type nad fad binding protein D3790_18265 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D3790_18270 ENOG4105C9B Cysteine desulfurase D3790_18275 ENOG4105ETT transcriptional Regulator, LysR family D3790_18280 ENOG4105M08 Membrane D3790_18285 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) D3790_18300 ENOG4108JJ6 Type I secretion system ATPase D3790_18305 ENOG4107QZV Type I secretion membrane fusion protein D3790_18310 ENOG4105DFG type I secretion outer membrane protein D3790_18315 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease D3790_18325 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D3790_18335 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) D3790_18340 ENOG4105WP7 tRNA pseudouridine synthase C D3790_18345 ENOG4105DR9 pseudouridine synthase D3790_18350 ENOG4105QDK Flavodoxin D3790_18355 ENOG4108T8E UPF0325 protein D3790_18385 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D3790_18390 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D3790_18395 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D3790_18400 ENOG4105CE9 30S ribosomal protein S2 D3790_18405 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D3790_18410 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D3790_18415 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D3790_18420 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D3790_18425 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D3790_18430 ENOG4105KNE Phosphatidate cytidylyltransferase D3790_18435 ENOG4105DZP Membrane-associated zinc metalloprotease D3790_18440 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D3790_18445 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) D3790_18450 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3790_18455 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D3790_18460 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3790_18465 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3790_18470 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3790_18475 ENOG4105C0B DNA polymerase III (alpha subunit) D3790_18480 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D3790_18490 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D3790_18495 ENOG4105M1T rho-binding antiterminator D3790_18500 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion D3790_18505 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D3790_18510 ENOG4108R96 Methyltransferase, YaeB family D3790_18520 ENOG4105D01 (LipO)protein D3790_18525 ENOG4108UMI ABC transporter, permease D3790_18530 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D3790_18535 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D3790_18565 ENOG4105CVG Homoserine O-transsuccinylase D3790_18570 ENOG4105HVQ Regulatory factor of maltose metabolism D3790_18575 ENOG4105CAR Terminase, large subunit D3790_18640 ENOG4106YSC D3790_18665 ENOG4107QP3 malate synthase g D3790_18670 ENOG4108I9X Isocitrate lyase D3790_18675 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) D3790_18685 ENOG4108UHU Aldolase D3790_18690 ENOG41069M3 Transcriptional regulator D3790_18705 ENOG4105CFH Aspartokinase D3790_18710 ENOG4107QP8 phosphohexose isomerase D3790_18715 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) D3790_18720 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) D3790_18725 ENOG4105E55 glycerol-3-phosphate acyltransferase D3790_18730 ENOG41080IJ Diacylglycerol kinase D3790_18735 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D3790_18740 ENOG4105MYN Zinc uptake regulation protein D3790_18760 ENOG4105CVR type I restriction-modification system D3790_18775 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D3790_18780 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D3790_18785 ENOG4105CDU Replicative dna helicase D3790_18790 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D3790_18795 ENOG4105CGF Aromatic amino acid aminotransferase D3790_18805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D3790_18810 ENOG4108UUM single-stranded DNA-binding protein D3790_18830 ENOG4107RX2 synthase D3790_18835 ENOG4105CHC glucokinase (EC 2.7.1.2) D3790_18840 ENOG4105WZK nitrite reductase NADPH small subunit D3790_18845 ENOG4107QZF nitrite reductase NADPH large subunit D3790_18850 ENOG41072TH Protein of unknown function (DUF1479) D3790_18880 ENOG4105C7N Xanthine uracil vitamin C permease D3790_18910 ENOG4105EEQ Na H antiporter D3790_18915 ENOG4105EMK carboxylate amino acid amine transporter D3790_18920 ENOG4105DZ2 Transcriptional regulator D3790_18925 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D3790_18935 ENOG4105C6Z Gluconate D3790_18940 ENOG4108I5U Uridine phosphorylase D3790_18950 ENOG4108KF1 Membrane D3790_18955 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3790_18960 ENOG4105JC1 sterol-binding domain protein D3790_18965 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D3790_18970 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D3790_18975 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D3790_18980 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D3790_18985 ENOG4105D52 delta-aminolevulinic acid dehydratase D3790_18990 ENOG4105MDZ Transcriptional activator rfaH D3790_18995 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D3790_19005 ENOG4105CHU acetyl-coa acetyltransferase D3790_19010 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3790_19015 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) D3790_19020 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D3790_19025 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D3790_19030 ENOG4108RR8 protoporphyrinogen oxidase D3790_19065 ENOG4107NA1 Endonuclease Exonuclease phosphatase D3790_19070 ENOG4105C85 amino acid D3790_19075 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D3790_19080 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D3790_19085 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D3790_19090 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D3790_19095 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D3790_19100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D3790_19105 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D3790_19110 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) D3790_19115 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) D3790_19120 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D3790_19125 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D3790_19130 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D3790_19135 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) D3790_19140 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D3790_19145 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D3790_19150 ENOG4108K5P (LipO)protein D3790_19160 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase D3790_19165 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3790_19175 ENOG4107R3N Filamentation induced by cAMP protein fic D3790_19180 ENOG4105D22 carbon starvation protein D3790_19185 ENOG4105VCD cytoplasmic protein D3790_19190 ENOG4105CKI cobalamin synthesis protein D3790_19195 ENOG4108W9T type 1 fimbriae regulatory protein D3790_19200 ENOG4105C44 Serine transporter D3790_19210 ENOG4105GPY SprT protein D3790_19240 ENOG4108JJA ABC, transporter D3790_19280 ENOG4105EQR Transposase IS116 IS110 IS902 D3790_19290 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D3790_19300 ENOG4108NRW Phospholipase, patatin family D3790_19305 ENOG4105EYA deoxyribonuclease D3790_19310 ENOG4105D9N nucleoside D3790_19315 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D3790_19320 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D3790_19325 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D3790_19330 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D3790_19340 ENOG4106PG1 outer membrane usher protein D3790_19345 ENOG4108FZ9 Chaperone D3790_19365 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D3790_19370 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D3790_19375 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D3790_19380 ENOG4105EXG Transcriptional regulator D3790_19390 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D3790_19395 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase D3790_19400 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D3790_19405 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D3790_19410 ENOG4105DTN riboflavin biosynthesis protein ribF D3790_19415 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) D3790_19420 ENOG41063Z6 transcriptional regulator, lysR family D3790_19425 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3790_19440 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic D3790_19445 ENOG4105DKQ ROK family D3790_19450 ENOG4105DH7 May be involved in recombination (By similarity) D3790_19475 ENOG4105PPN plasmid maintenance protein, CcdB D3790_19505 ENOG4108ZZF transport protein (ExbD) D3790_19510 ENOG4105CWK Biopolymer transport protein, ExbB D3790_19515 ENOG4105C28 cystathionine D3790_19520 ENOG4108K81 inner membrane protein YghB D3790_19525 ENOG4105CV8 reductase D3790_19535 ENOG41062Z9 Membrane D3790_19540 ENOG4105EAC phosphoserine phosphatase D3790_19545 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D3790_19560 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3790_19565 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase D3790_19580 ENOG4105KRQ Addiction module toxin, Txe YoeB family D3790_19590 ENOG4105E0A ABC, transporter D3790_19595 ENOG4108IHU transport system permease protein D3790_19600 ENOG4105DQ5 transport system permease protein D3790_19605 ENOG4108HUF Transporter D3790_19610 ENOG4105GAV receptor D3790_19615 ENOG4108S3W Anti-feci sigma factor, fecr D3790_19620 ENOG4108SF5 RNA Polymerase D3790_19635 ENOG4105H38 Membrane D3790_19680 ENOG4105PWE CRISPR-associated protein cas2 D3790_19685 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) D3790_19695 ENOG4108VWQ crispr-associated protein D3790_19715 ENOG4105DTT CRISPR-associated helicase, cas3 D3790_19735 ENOG4108JDX DNA polymerase iii, epsilon subunit D3790_19740 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3790_19745 ENOG4105D1A Methyltransferase