locus-tag	class	description
XPG1_0002	COG0592	DNA-directed DNA polymerase activity
XPG1_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XPG1_0004	COG0187	DNA topoisomerase II activity
XPG1_0005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XPG1_0012	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XPG1_0013	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XPG1_0014	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XPG1_0015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XPG1_0016	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XPG1_0017	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XPG1_0018	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XPG1_0019	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XPG1_0021	COG0356	it plays a direct role in the translocation of protons across the membrane
XPG1_0022	COG3312	ion transport
XPG1_0023	COG0357	Ribosomal RNA small subunit methyltransferase G
XPG1_0024	COG0445	tRNA wobble uridine modification
XPG1_0025	COG0716	FMN binding
XPG1_0026	COG1522	sequence-specific DNA binding
XPG1_0027	COG2502	aspartate--ammonia ligase
XPG1_0028	COG2425	protein containing a von Willebrand factor type A (vWA) domain
XPG1_0029	COG0714	Associated with various cellular activities
XPG1_0030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPG1_0031	COG0477	Major facilitator Superfamily
XPG1_0037	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPG1_0038	COG3162	membrane
XPG1_0039	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XPG1_0040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XPG1_0041	COG2258	MOSC domain
XPG1_0042	COG0180	Tryptophanyl-tRNA synthetase
XPG1_0043	COG0546	phosphoglycolate phosphatase activity
XPG1_0044	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
XPG1_0047	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XPG1_0048	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XPG1_0050	COG4796	Type ii and iii secretion system protein
XPG1_0054	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XPG1_0055	COG0494	nUDIX hydrolase
XPG1_0057	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
XPG1_0058	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XPG1_0059	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
XPG1_0062	COG0583	DNA-binding transcription factor activity
XPG1_0063	COG2814	Major facilitator Superfamily
XPG1_0066	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
XPG1_0068	COG0667	Aldo Keto reductase
XPG1_0072	COG0583	DNA-binding transcription factor activity
XPG1_0073	COG2081	HI0933 family
XPG1_0074	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_0077	COG0789	Transcriptional regulator
XPG1_0079	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XPG1_0089	COG0742	ribosomal rna small subunit methyltransferase
XPG1_0093	COG0589	response to stress
XPG1_0094	COG0306	phosphate transporter
XPG1_0096	COG2814	Major facilitator Superfamily
XPG1_0098	COG1309	transcriptional regulator
XPG1_0102	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_0103	COG0477	Major facilitator Superfamily
XPG1_0107	COG1309	transcriptional regulator
XPG1_0109	COG1764	response to oxidative stress
XPG1_0116	COG0366	Alpha amylase catalytic
XPG1_0117	COG1263	PTS System
XPG1_0117	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_0118	COG0626	cystathionine gamma-synthase activity
XPG1_0119	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
XPG1_0120	COG1349	DNA-binding transcription factor activity
XPG1_0121	COG0705	Rhomboid family
XPG1_0122	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPG1_0123	COG0316	Belongs to the HesB IscA family
XPG1_0123	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XPG1_0125	COG0596	Alpha beta hydrolase
XPG1_0127	COG2814	Major facilitator Superfamily
XPG1_0140	COG1918	ferrous iron import across plasma membrane
XPG1_0144	COG2183	response to ionizing radiation
XPG1_0145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPG1_0146	COG0745	RESPONSE REGULATOR receiver
XPG1_0148	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XPG1_0149	COG0573	inorganic phosphate transmembrane transporter activity
XPG1_0150	COG0581	inorganic phosphate transmembrane transporter activity
XPG1_0151	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XPG1_0152	COG0704	Plays a role in the regulation of phosphate uptake
XPG1_0153	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_0154	COG0765	amino acid transport
XPG1_0155	COG0765	amino acid transport
XPG1_0156	COG2252	PERMEase
XPG1_0159	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPG1_0160	COG2204	response regulator
XPG1_0189	COG1011	Hydrolase
XPG1_0190	COG1490	D-aminoacyl-tRNA deacylase activity
XPG1_0191	COG0456	acetyltransferase
XPG1_0192	COG2982	Protein involved in outer membrane biogenesis
XPG1_0193	COG2233	PERMEase
XPG1_0194	COG0786	glutamate:sodium symporter activity
XPG1_0195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XPG1_0196	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPG1_0198	COG0194	GDP metabolic process
XPG1_0199	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XPG1_0200	COG2860	membrane
XPG1_0201	COG0823	Involved in the tonB-independent uptake of proteins
XPG1_0202	COG5645	(Lipo)protein
XPG1_0203	COG3977	Valine--pyruvate aminotransferase
XPG1_0204	COG2818	Glycosylase
XPG1_0205	COG0752	glycyl-tRNA synthetase alpha subunit
XPG1_0206	COG0751	glycine-tRNA ligase activity
XPG1_0207	COG0747	negative chemotaxis
XPG1_0208	COG0601	transmembrane transport
XPG1_0209	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XPG1_0210	COG0444	Belongs to the ABC transporter superfamily
XPG1_0211	COG4608	Belongs to the ABC transporter superfamily
XPG1_0212	COG2199	diguanylate cyclase activity
XPG1_0212	COG2200	EAL domain
XPG1_0213	COG0612	Peptidase, M16
XPG1_0217	COG1942	4-Oxalocrotonate Tautomerase
XPG1_0218	COG1295	ribonuclease BN
XPG1_0240	COG3501	Rhs element vgr protein
XPG1_0243	COG3209	COG3209 Rhs family protein
XPG1_0246	COG2932	Transcriptional regulator
XPG1_0247	COG0358	DNA primase activity
XPG1_0248	COG4974	Belongs to the 'phage' integrase family
XPG1_0250	COG3209	COG3209 Rhs family protein
XPG1_0252	COG4372	Transposase
XPG1_0255	COG2801	Transposase and inactivated derivatives
XPG1_0256	COG3316	Transposase and inactivated derivatives
XPG1_0263	COG4795	General secretion pathway protein
XPG1_0266	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XPG1_0268	COG1074	ATP-dependent DNA helicase activity
XPG1_0270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XPG1_0273	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPG1_0275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
XPG1_0276	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XPG1_0277	COG2166	iron-sulfur cluster assembly
XPG1_0278	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XPG1_0281	COG0583	DNA-binding transcription factor activity
XPG1_0282	COG2363	Small membrane protein
XPG1_0284	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XPG1_0286	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XPG1_0287	COG0126	phosphoglycerate kinase activity
XPG1_0289	COG3104	oligopeptide transport
XPG1_0290	COG2501	S4 domain
XPG1_0291	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XPG1_0292	COG0582	viral genome integration into host DNA
XPG1_0301	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_0314	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_0333	COG5484	DNA packaging
XPG1_0333	COG3728	DNA packaging
XPG1_0375	COG0525	valine-tRNA ligase activity
XPG1_0376	COG2927	DNA polymerase III (CHI subunit)
XPG1_0377	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPG1_0378	COG0795	lipopolysaccharide-transporting ATPase activity
XPG1_0379	COG0795	lipopolysaccharide-transporting ATPase activity
XPG1_0380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
XPG1_0396	COG2814	Major facilitator Superfamily
XPG1_0398	COG0583	DNA-binding transcription factor activity
XPG1_0411	COG1715	Restriction endonuclease
XPG1_0414	COG0243	molybdopterin cofactor binding
XPG1_0417	COG0419	ATPase involved in DNA repair
XPG1_0418	COG0420	3'-5' exonuclease activity
XPG1_0419	COG0745	RESPONSE REGULATOR receiver
XPG1_0420	COG5002	protein histidine kinase activity
XPG1_0421	COG1114	Component of the transport system for branched-chain amino acids
XPG1_0423	COG0450	alkyl hydroperoxide reductase
XPG1_0424	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
XPG1_0425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XPG1_0426	COG0343	queuine tRNA-ribosyltransferase activity
XPG1_0427	COG1862	Preprotein translocase
XPG1_0429	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XPG1_0430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XPG1_0431	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPG1_0431	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XPG1_0432	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XPG1_0433	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPG1_0434	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XPG1_0435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
XPG1_0441	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
XPG1_0442	COG1757	Na H antiporter
XPG1_0443	COG1609	Transcriptional regulator
XPG1_0446	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XPG1_0447	COG0142	geranyltranstransferase activity
XPG1_0449	COG0301	tRNA thio-modification
XPG1_0449	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPG1_0450	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
XPG1_0451	COG1666	GTP binding
XPG1_0452	COG2814	Major facilitator Superfamily
XPG1_0453	COG0109	protoheme IX farnesyltransferase activity
XPG1_0454	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XPG1_0455	COG1845	cytochrome c oxidase, subunit III
XPG1_0456	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XPG1_0457	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XPG1_0459	COG2223	nitrite transmembrane transporter activity
XPG1_0460	COG3056	Lipoprotein
XPG1_0461	COG0271	Belongs to the BolA IbaG family
XPG1_0463	COG0740	serine-type endopeptidase activity
XPG1_0464	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XPG1_0465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
XPG1_0467	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPG1_0468	COG1555	photosystem II stabilization
XPG1_0469	COG0824	Thioesterase
XPG1_0470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XPG1_0472	COG1522	sequence-specific DNA binding
XPG1_0473	COG1132	(ABC) transporter
XPG1_0474	COG1132	(ABC) transporter
XPG1_0475	COG0347	Belongs to the P(II) protein family
XPG1_0476	COG0004	ammonium transporteR
XPG1_0479	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_0480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_0481	COG1309	transcriptional regulator
XPG1_0484	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
XPG1_0486	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XPG1_0487	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XPG1_0488	COG0326	Molecular chaperone. Has ATPase activity
XPG1_0489	COG0563	adenylate kinase activity
XPG1_0490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XPG1_0491	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XPG1_0492	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XPG1_0493	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XPG1_0493	COG4651	solute:proton antiporter activity
XPG1_0496	COG0737	Belongs to the 5'-nucleotidase family
XPG1_0498	COG3735	TraB family
XPG1_0499	COG2217	Heavy metal translocating P-type atpase
XPG1_0501	COG1585	Membrane protein implicated in regulation of membrane protease activity
XPG1_0502	COG0330	HflC and HflK could
XPG1_0503	COG3118	belongs to the thioredoxin family
XPG1_0504	COG0300	oxidoreductase activity
XPG1_0505	COG2755	lipolytic protein G-D-S-L family
XPG1_0506	COG4181	ATPase activity
XPG1_0507	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
XPG1_0510	COG2873	o-acetylhomoserine
XPG1_0514	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_0515	COG1518	maintenance of DNA repeat elements
XPG1_0521	COG1203	CRISPR-associated helicase, Cas3
XPG1_0530	COG1609	Transcriptional regulator
XPG1_0531	COG3265	gluconokinase activity
XPG1_0532	COG2610	gluconate transmembrane transporter activity
XPG1_0536	COG2992	FlgJ-related protein
XPG1_0548	COG1358	cellular component organization or biogenesis
XPG1_0550	COG2862	Uncharacterized protein family, UPF0114
XPG1_0553	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
XPG1_0554	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
XPG1_0555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_0556	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPG1_0558	COG3842	ATPase activity
XPG1_0559	COG1176	ABC-type spermidine putrescine transport system, permease component I
XPG1_0560	COG1177	transmembrane transport
XPG1_0561	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
XPG1_0564	COG3153	acetyltransferase
XPG1_0567	COG3787	Belongs to the UPF0306 family
XPG1_0568	COG0602	queuosine metabolic process
XPG1_0571	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
XPG1_0575	COG5505	Protein of unknown function (DUF819)
XPG1_0577	COG0582	viral genome integration into host DNA
XPG1_0579	COG0814	amino acid
XPG1_0583	COG0534	Mate efflux family protein
XPG1_0587	COG0288	reversible hydration of carbon dioxide
XPG1_0589	COG1131	(ABC) transporter
XPG1_0590	COG0842	Transport permease protein
XPG1_0591	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPG1_0594	COG1349	DNA-binding transcription factor activity
XPG1_0595	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
XPG1_0596	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_0598	COG3716	PTS system mannose fructose sorbose family IID component
XPG1_0599	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_0600	COG2222	sugar isomerase
XPG1_0601	COG0191	fructose-bisphosphate aldolase activity
XPG1_0603	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XPG1_0604	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XPG1_0605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XPG1_0606	COG0617	tRNA 3'-terminal CCA addition
XPG1_0607	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPG1_0608	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XPG1_0610	COG1489	DNA binding
XPG1_0611	COG1643	Atp-dependent helicase
XPG1_0612	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPG1_0613	COG1278	Cold shock
XPG1_0614	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPG1_0615	COG0316	Belongs to the HesB IscA family
XPG1_0616	COG1396	sequence-specific DNA binding
XPG1_0617	COG3135	benzoate transporter
XPG1_0628	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
XPG1_0629	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
XPG1_0630	COG0232	Belongs to the dGTPase family. Type 2 subfamily
XPG1_0632	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPG1_0633	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XPG1_0634	COG3956	TIGRFAM MazG family protein
XPG1_0635	COG0504	CTP synthase activity
XPG1_0636	COG0148	phosphopyruvate hydratase activity
XPG1_0637	COG0471	metal ion transport
XPG1_0640	COG3091	SprT-like family
XPG1_0643	COG1166	arginine decarboxylase activity
XPG1_0644	COG0010	Belongs to the arginase family
XPG1_0648	COG2345	Transcriptional regulator
XPG1_0649	COG1262	PFAM Formylglycine-generating sulfatase enzyme
XPG1_0652	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_0655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
XPG1_0659	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XPG1_0660	COG0626	cystathionine gamma-synthase activity
XPG1_0661	COG0242	peptide deformylase activity
XPG1_0662	COG3066	DNA modification
XPG1_0663	COG0473	3-isopropylmalate dehydrogenase activity
XPG1_0666	COG1022	Amp-dependent synthetase and ligase
XPG1_0667	COG0028	Belongs to the TPP enzyme family
XPG1_0669	COG1609	Transcriptional regulator
XPG1_0671	COG2001	Belongs to the MraZ family
XPG1_0672	COG0275	rRNA processing
XPG1_0673	COG3116	cell division
XPG1_0674	COG0768	penicillin binding
XPG1_0675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XPG1_0676	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XPG1_0677	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPG1_0678	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XPG1_0679	COG0772	Belongs to the SEDS family
XPG1_0680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XPG1_0681	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPG1_0682	COG1181	Belongs to the D-alanine--D-alanine ligase family
XPG1_0683	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XPG1_0684	COG0849	cell division
XPG1_0686	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XPG1_0689	COG0653	protein targeting
XPG1_0690	COG0488	(ABC) transporter
XPG1_0691	COG0494	nUDIX hydrolase
XPG1_0693	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
XPG1_0694	COG0237	dephospho-CoA kinase activity
XPG1_0696	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XPG1_0697	COG4969	Belongs to the N-Me-Phe pilin family
XPG1_0698	COG3023	N-Acetylmuramoyl-L-alanine amidase
XPG1_0699	COG3725	Membrane protein required for beta-lactamase induction
XPG1_0701	COG2186	Transcriptional regulator
XPG1_0702	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
XPG1_0703	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPG1_0704	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPG1_0708	COG2801	Transposase and inactivated derivatives
XPG1_0709	COG2963	transposase activity
XPG1_0711	COG3246	L-lysine catabolic process to acetate
XPG1_0713	COG0183	Belongs to the thiolase family
XPG1_0714	COG0113	porphobilinogen synthase activity
XPG1_0715	COG0697	spore germination
XPG1_0719	COG2313	pseudouridylate synthase activity
XPG1_0721	COG0546	phosphoglycolate phosphatase activity
XPG1_0723	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XPG1_0731	COG3112	Uncharacterised protein family (UPF0231)
XPG1_0732	COG0668	transmembrane transport
XPG1_0734	COG0583	DNA-binding transcription factor activity
XPG1_0735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XPG1_0736	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPG1_0737	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XPG1_0741	COG3079	Belongs to the UPF0149 family
XPG1_0742	COG0006	proline dipeptidase activity
XPG1_0743	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPG1_0744	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPG1_0745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XPG1_0746	COG0509	glycine decarboxylation via glycine cleavage system
XPG1_0747	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPG1_0747	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XPG1_0749	COG0354	folic acid binding
XPG1_0751	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XPG1_0753	COG0716	FMN binding
XPG1_0754	COG4974	Belongs to the 'phage' integrase family
XPG1_0755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XPG1_0756	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XPG1_0757	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XPG1_0758	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XPG1_0759	COG0582	viral genome integration into host DNA
XPG1_0766	COG5433	transposase activity
XPG1_0767	COG3676	manually curated
XPG1_0776	COG0741	lytic transglycosylase activity
XPG1_0776	COG1388	LysM domain
XPG1_0777	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPG1_0778	COG2226	methyltransferase
XPG1_0779	COG0328	RNA-DNA hybrid ribonuclease activity
XPG1_0780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_0783	COG2197	response regulator
XPG1_0787	COG0501	Belongs to the peptidase M48B family
XPG1_0791	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
XPG1_0793	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
XPG1_0794	COG0318	PFAM AMP-dependent synthetase and ligase
XPG1_0795	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_0796	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPG1_0810	COG5301	cellulose 1,4-beta-cellobiosidase activity
XPG1_0811	COG1442	glycosyl transferase family 8
XPG1_0813	COG5301	cellulose 1,4-beta-cellobiosidase activity
XPG1_0814	COG0438	transferase activity, transferring glycosyl groups
XPG1_0815	COG5433	transposase activity
XPG1_0819	COG2194	sulfuric ester hydrolase activity
XPG1_0825	COG0859	PFAM glycosyl transferase family 9
XPG1_0835	COG2841	Protein conserved in bacteria
XPG1_0841	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
XPG1_0846	COG2353	YceI-like domain
XPG1_0847	COG3038	cytochrome b561
XPG1_0849	COG0625	glutathione transferase activity
XPG1_0856	COG2814	Major facilitator Superfamily
XPG1_0857	COG2198	Histidine kinase
XPG1_0857	COG0642	Histidine kinase
XPG1_0858	COG2197	response regulator
XPG1_0859	COG2205	protein histidine kinase activity
XPG1_0859	COG0784	Response regulator, receiver
XPG1_0861	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XPG1_0862	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPG1_0863	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XPG1_0864	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XPG1_0882	COG2963	transposase activity
XPG1_0883	COG2801	Transposase and inactivated derivatives
XPG1_0885	COG0582	viral genome integration into host DNA
XPG1_0888	COG0582	viral genome integration into host DNA
XPG1_0902	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XPG1_0924	COG1802	Transcriptional regulator
XPG1_0924	COG4626	Terminase
XPG1_0955	COG1802	Transcriptional regulator
XPG1_0955	COG4626	Terminase
XPG1_0956	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_0960	COG1674	ftsk spoiiie
XPG1_0969	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XPG1_0970	COG2867	negative regulation of translational initiation
XPG1_0971	COG2914	Belongs to the UPF0125 (RnfH) family
XPG1_0972	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPG1_0973	COG0497	DNA recombination
XPG1_0974	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XPG1_0975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XPG1_0976	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XPG1_0978	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
XPG1_0980	COG0513	Belongs to the DEAD box helicase family
XPG1_0981	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
XPG1_0982	COG1595	DNA-templated transcription, initiation
XPG1_0985	COG3086	response to oxidative stress
XPG1_0986	COG0481	GTPase activity
XPG1_0987	COG0681	Belongs to the peptidase S26 family
XPG1_0988	COG0571	ribonuclease III activity
XPG1_0989	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XPG1_0990	COG1381	Involved in DNA repair and RecF pathway recombination
XPG1_0991	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XPG1_0992	COG0736	holo-[acyl-carrier-protein] synthase activity
XPG1_0993	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XPG1_1017	COG3772	lysozyme
XPG1_1020	COG1598	PFAM Uncharacterised protein family UPF0150
XPG1_1022	COG5484	DNA packaging
XPG1_1022	COG3728	DNA packaging
XPG1_1023	COG1783	phage Terminase large subunit
XPG1_1039	COG1196	nuclear chromosome segregation
XPG1_1039	COG0741	lytic transglycosylase activity
XPG1_1039	COG0739	heme binding
XPG1_1057	COG0590	tRNA wobble adenosine to inosine editing
XPG1_1058	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
XPG1_1059	COG0047	phosphoribosylformylglycinamidine synthase activity
XPG1_1059	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XPG1_1061	COG2205	protein histidine kinase activity
XPG1_1062	COG3170	Tfp pilus assembly protein FimV
XPG1_1063	COG2204	response regulator
XPG1_1064	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPG1_1064	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XPG1_1065	COG0347	Belongs to the P(II) protein family
XPG1_1066	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XPG1_1066	COG1017	nitric oxide dioxygenase activity
XPG1_1067	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XPG1_1068	COG2814	Major facilitator Superfamily
XPG1_1069	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_1070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_1071	COG1120	ATPase activity
XPG1_1075	COG4607	ABC-type enterochelin transport system periplasmic component
XPG1_1076	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
XPG1_1077	COG4774	siderophore transport
XPG1_1077	COG1629	transport
XPG1_1078	COG0662	Cupin 2, conserved barrel domain protein
XPG1_1079	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_1080	COG3433	isochorismatase activity
XPG1_1080	COG1535	isochorismatase
XPG1_1081	COG1021	2,3-dihydroxybenzoate-AMP ligase
XPG1_1082	COG1169	isochorismate synthase
XPG1_1088	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
XPG1_1089	COG1959	2 iron, 2 sulfur cluster binding
XPG1_1090	COG1104	cysteine desulfurase activity
XPG1_1091	COG0822	iron-sulfur transferase activity
XPG1_1092	COG0316	Belongs to the HesB IscA family
XPG1_1093	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XPG1_1094	COG0443	Heat shock 70 kDa protein
XPG1_1095	COG0633	Ferredoxin
XPG1_1096	COG2975	iron-sulfur cluster assembly
XPG1_1097	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XPG1_1099	COG2373	Large extracellular alpha-helical protein
XPG1_1100	COG4953	penicillin-binding protein 1C
XPG1_1102	COG3655	Transcriptional regulator
XPG1_1104	COG0105	UTP biosynthetic process
XPG1_1105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XPG1_1108	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XPG1_1109	COG0124	histidyl-tRNA synthetase
XPG1_1110	COG2976	Protein conserved in bacteria
XPG1_1111	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPG1_1112	COG1160	GTP binding
XPG1_1115	COG0408	coproporphyrinogen oxidase activity
XPG1_1116	COG3423	Transcriptional regulator
XPG1_1119	COG4626	Terminase
XPG1_1119	COG1802	Transcriptional regulator
XPG1_1137	COG0456	acetyltransferase
XPG1_1140	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XPG1_1141	COG4208	sulfate ABC transporter
XPG1_1142	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XPG1_1143	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XPG1_1144	COG2190	(PTS) system
XPG1_1146	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_1149	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XPG1_1151	COG3115	cell septum assembly
XPG1_1152	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XPG1_1153	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XPG1_1154	COG3530	Putative quorum-sensing-regulated virulence factor
XPG1_1155	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_1156	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPG1_1169	COG0183	Belongs to the thiolase family
XPG1_1170	COG1024	Enoyl-CoA hydratase
XPG1_1170	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPG1_1171	COG2062	phosphohistidine phosphatase, SixA
XPG1_1172	COG2840	Smr protein MutS2
XPG1_1173	COG1228	amidohydrolase
XPG1_1174	COG0010	Belongs to the arginase family
XPG1_1176	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
XPG1_1177	COG2986	histidine ammonia-lyase
XPG1_1182	COG2890	protein-(glutamine-N5) methyltransferase activity
XPG1_1183	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XPG1_1184	COG0730	response to heat
XPG1_1185	COG3101	peptidyl-lysine hydroxylation
XPG1_1187	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPG1_1187	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
XPG1_1188	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPG1_1195	COG0640	Transcriptional regulator
XPG1_1199	COG0642	Histidine kinase
XPG1_1201	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPG1_1202	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XPG1_1203	COG0101	tRNA pseudouridine synthase activity
XPG1_1204	COG0586	Pfam SNARE associated Golgi protein
XPG1_1205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XPG1_1206	COG0285	dihydrofolate synthase activity
XPG1_1207	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
XPG1_1208	COG1286	toxin biosynthetic process
XPG1_1209	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
XPG1_1210	COG0163	prenyltransferase activity
XPG1_1211	COG1090	epimerase
XPG1_1212	COG0625	glutathione transferase activity
XPG1_1213	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
XPG1_1214	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XPG1_1215	COG3138	arginine N-succinyltransferase
XPG1_1216	COG1012	belongs to the aldehyde dehydrogenase family
XPG1_1217	COG3724	N-succinylarginine dihydrolase activity
XPG1_1218	COG2988	succinylglutamate desuccinylase activity
XPG1_1219	COG1113	amino acid transport
XPG1_1223	COG0857	belongs to the CobB CobQ family
XPG1_1223	COG0280	phosphate acetyltransferase
XPG1_1224	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
XPG1_1226	COG0490	domain, Protein
XPG1_1226	COG0471	metal ion transport
XPG1_1227	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
XPG1_1228	COG0436	Aminotransferase
XPG1_1229	COG0583	DNA-binding transcription factor activity
XPG1_1230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_1231	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_1232	COG0649	NAD binding
XPG1_1232	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_1233	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XPG1_1235	COG1034	ATP synthesis coupled electron transport
XPG1_1237	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_1238	COG0839	Belongs to the complex I subunit 6 family
XPG1_1239	COG0713	ATP synthesis coupled electron transport
XPG1_1240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
XPG1_1241	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XPG1_1242	COG1007	ATP synthesis coupled electron transport
XPG1_1243	COG2200	EAL domain
XPG1_1245	COG2199	diguanylate cyclase activity
XPG1_1248	COG1215	transferase activity, transferring glycosyl groups
XPG1_1249	COG0726	polysaccharide deacetylase
XPG1_1249	COG1649	PFAM Uncharacterised BCR, COG1649
XPG1_1250	COG0457	Tetratricopeptide repeat
XPG1_1253	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
XPG1_1254	COG0596	Alpha beta hydrolase
XPG1_1255	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
XPG1_1256	COG1441	menaquinone biosynthetic process
XPG1_1259	COG0814	amino acid
XPG1_1260	COG2814	Major facilitator Superfamily
XPG1_1262	COG3093	addiction module antidote protein HigA
XPG1_1267	COG2189	Belongs to the N(4) N(6)-methyltransferase family
XPG1_1271	COG3676	manually curated
XPG1_1276	COG3083	sulfuric ester hydrolase activity
XPG1_1277	COG3082	Protein of unknown function (DUF1414)
XPG1_1278	COG3081	Nucleoid-associated protein
XPG1_1279	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XPG1_1280	COG1061	Type III restriction enzyme res subunit
XPG1_1281	COG1187	pseudouridine synthase activity
XPG1_1282	COG2814	Major facilitator Superfamily
XPG1_1285	COG0791	NLP P60 protein
XPG1_1286	COG0671	phosphoesterase, PA-phosphatase related
XPG1_1289	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPG1_1291	COG1105	Belongs to the carbohydrate kinase PfkB family
XPG1_1292	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
XPG1_1293	COG2855	membrane
XPG1_1295	COG0583	DNA-binding transcription factor activity
XPG1_1296	COG0833	amino acid
XPG1_1298	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_1299	COG1120	ATPase activity
XPG1_1300	COG4771	TonB-dependent receptor
XPG1_1302	COG0531	amino acid
XPG1_1303	COG0277	FAD linked oxidase domain protein
XPG1_1304	COG2925	Exonuclease
XPG1_1307	COG2926	Belongs to the UPF0265 family
XPG1_1308	COG0702	epimerase
XPG1_1309	COG1530	ribonuclease E activity
XPG1_1311	COG0564	pseudouridine synthase activity
XPG1_1312	COG0424	maF-like protein
XPG1_1313	COG1399	metal-binding, possibly nucleic acid-binding protein
XPG1_1314	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XPG1_1315	COG0416	fatty acid biosynthetic process
XPG1_1316	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XPG1_1317	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
XPG1_1318	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_1319	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPG1_1320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPG1_1321	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPG1_1322	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XPG1_1323	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
XPG1_1324	COG0470	DNA polymerase III
XPG1_1325	COG0084	hydrolase, TatD family'
XPG1_1326	COG0537	adenosine 5'-monophosphoramidase activity
XPG1_1327	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
XPG1_1329	COG1472	Belongs to the glycosyl hydrolase 3 family
XPG1_1330	COG1252	NADH dehydrogenase
XPG1_1340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XPG1_1343	COG4591	ABC-type transport system involved in lipoprotein release permease component
XPG1_1344	COG1136	(ABC) transporter
XPG1_1345	COG4591	ABC-type transport system involved in lipoprotein release permease component
XPG1_1346	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
XPG1_1347	COG2195	Cleaves the N-terminal amino acid of tripeptides
XPG1_1348	COG2850	peptidyl-arginine hydroxylation
XPG1_1349	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPG1_1350	COG2205	protein histidine kinase activity
XPG1_1351	COG0745	RESPONSE REGULATOR receiver
XPG1_1354	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
XPG1_1355	COG2915	High frequency lysogenization protein hflD homolog
XPG1_1356	COG0482	sulfurtransferase activity
XPG1_1357	COG1187	pseudouridine synthase activity
XPG1_1359	COG0538	isocitrate dehydrogenase activity
XPG1_1360	COG0582	viral genome integration into host DNA
XPG1_1366	COG3723	Recombinational DNA repair protein, rece pathway
XPG1_1367	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_1380	COG1846	Transcriptional regulator
XPG1_1399	COG1783	phage Terminase large subunit
XPG1_1403	COG2369	cell adhesion
XPG1_1427	COG0538	isocitrate dehydrogenase activity
XPG1_1433	COG1115	amino acid carrier protein
XPG1_1434	COG3708	Transcriptional regulator
XPG1_1434	COG2207	Transcriptional regulator
XPG1_1437	COG1278	Cold shock
XPG1_1438	COG0351	phosphomethylpyrimidine kinase
XPG1_1439	COG1830	Aldolase
XPG1_1441	COG2814	Major facilitator Superfamily
XPG1_1442	COG0745	RESPONSE REGULATOR receiver
XPG1_1443	COG2205	protein histidine kinase activity
XPG1_1444	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_1445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XPG1_1446	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_1448	COG2239	Acts as a magnesium transporter
XPG1_1449	COG0248	Ppx GppA phosphatase
XPG1_1450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XPG1_1451	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPG1_1452	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XPG1_1453	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XPG1_1454	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
XPG1_1455	COG2233	PERMEase
XPG1_1456	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XPG1_1457	COG1393	Belongs to the ArsC family
XPG1_1458	COG4783	chaperone-mediated protein folding
XPG1_1459	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XPG1_1460	COG2716	regulation of RNA biosynthetic process
XPG1_1461	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XPG1_1463	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
XPG1_1464	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XPG1_1468	COG2707	UPF0756 membrane protein
XPG1_1469	COG1444	tRNA N-acetyltransferase activity
XPG1_1471	COG1876	peptidase activity
XPG1_1472	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPG1_1473	COG1393	Belongs to the ArsC family
XPG1_1474	COG2197	response regulator
XPG1_1475	COG0281	malic enzyme
XPG1_1475	COG0280	phosphate acetyltransferase
XPG1_1477	COG1570	exodeoxyribonuclease VII activity
XPG1_1478	COG0516	GMP reductase activity
XPG1_1478	COG0517	IMP dehydrogenase activity
XPG1_1479	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XPG1_1479	COG0519	Catalyzes the synthesis of GMP from XMP
XPG1_1480	COG0582	viral genome integration into host DNA
XPG1_1498	COG2197	response regulator
XPG1_1499	COG3851	Histidine kinase
XPG1_1500	COG2271	Major facilitator Superfamily
XPG1_1502	COG2226	methyltransferase
XPG1_1503	COG1971	Probably functions as a manganese efflux pump
XPG1_1505	COG4811	Protein of unknown function (DUF986)
XPG1_1506	COG3716	PTS system mannose fructose sorbose family IID component
XPG1_1507	COG3715	PTS system
XPG1_1508	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_1508	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_1509	COG1760	l-serine dehydratase
XPG1_1510	COG0494	nUDIX hydrolase
XPG1_1512	COG3140	Belongs to the UPF0181 family
XPG1_1516	COG1528	Iron-storage protein
XPG1_1517	COG2372	response to copper ion
XPG1_1518	COG1276	copper resistance
XPG1_1521	COG1956	GAF domain-containing protein
XPG1_1522	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
XPG1_1525	COG0501	Belongs to the peptidase M48B family
XPG1_1527	COG1988	membrane-bound metal-dependent
XPG1_1528	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPG1_1530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XPG1_1531	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XPG1_1532	COG1121	(ABC) transporter
XPG1_1533	COG0803	Belongs to the bacterial solute-binding protein 9 family
XPG1_1534	COG0741	lytic transglycosylase activity
XPG1_1537	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XPG1_1538	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XPG1_1539	COG0291	Belongs to the bacterial ribosomal protein bL35 family
XPG1_1542	COG0072	phenylalanine-tRNA ligase activity
XPG1_1542	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPG1_1543	COG0776	regulation of translation
XPG1_1544	COG4139	cobalamin transport
XPG1_1545	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
XPG1_1546	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XPG1_1547	COG0463	Glycosyl transferase, family 2
XPG1_1548	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XPG1_1548	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPG1_1549	COG0726	polysaccharide deacetylase
XPG1_1550	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XPG1_1551	COG2076	Multidrug Resistance protein
XPG1_1552	COG2076	Multidrug Resistance protein
XPG1_1553	COG0791	NLP P60 protein
XPG1_1554	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
XPG1_1556	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
XPG1_1557	COG4558	Periplasmic binding protein
XPG1_1558	COG3720	iron ion transport
XPG1_1563	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPG1_1564	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XPG1_1565	COG0574	Belongs to the PEP-utilizing enzyme family
XPG1_1565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XPG1_1566	COG0628	permease
XPG1_1569	COG0247	lactate metabolic process
XPG1_1569	COG0277	FAD linked oxidase domain protein
XPG1_1570	COG2050	protein possibly involved in aromatic compounds catabolism
XPG1_1571	COG1388	LysM domain
XPG1_1571	COG1376	ErfK ybiS ycfS ynhG family protein
XPG1_1572	COG4238	major outer membrane lipoprotein
XPG1_1574	COG0469	pyruvate kinase activity
XPG1_1575	COG0534	Mate efflux family protein
XPG1_1577	COG0307	riboflavin synthase, alpha
XPG1_1578	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
XPG1_1579	COG2814	Major facilitator Superfamily
XPG1_1580	COG0583	DNA-binding transcription factor activity
XPG1_1581	COG1609	Transcriptional regulator
XPG1_1582	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XPG1_1583	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XPG1_1584	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XPG1_1585	COG0346	lactoylglutathione lyase activity
XPG1_1587	COG3133	Outer membrane lipoprotein
XPG1_1588	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XPG1_1589	COG0259	pyridoxamine-phosphate oxidase activity
XPG1_1590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XPG1_1591	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
XPG1_1594	COG4172	Belongs to the ABC transporter superfamily
XPG1_1595	COG4171	peptide transport system, permease
XPG1_1596	COG4168	peptide transport system, permease
XPG1_1597	COG4166	transmembrane transport
XPG1_1598	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
XPG1_1600	COG1842	Phage shock protein A
XPG1_1602	COG1983	PspC domain protein
XPG1_1603	COG3106	COG3106 Predicted ATPase
XPG1_1608	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
XPG1_1609	COG0598	Magnesium transport protein CorA
XPG1_1610	COG0037	tRNA processing
XPG1_1616	COG1132	(ABC) transporter
XPG1_1619	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XPG1_1620	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XPG1_1621	COG2186	Transcriptional regulator
XPG1_1623	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XPG1_1624	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XPG1_1628	COG3139	Protein of unknown function (DUF1315)
XPG1_1631	COG1335	isochorismatase
XPG1_1632	COG0252	asparaginase activity
XPG1_1633	COG0616	signal peptide processing
XPG1_1634	COG0778	Nitroreductase
XPG1_1635	COG0709	Synthesizes selenophosphate from selenide and ATP
XPG1_1635	COG0709	Synthesizes selenophosphate from selenide and ATP
XPG1_1636	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XPG1_1637	COG0708	Exodeoxyribonuclease III
XPG1_1640	COG0788	formyltetrahydrofolate deformylase activity
XPG1_1641	COG3012	SEC-C Motif Domain Protein
XPG1_1642	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XPG1_1645	COG2916	Histone family protein nucleoid-structuring protein H-NS
XPG1_1647	COG1435	thymidine kinase activity
XPG1_1648	COG1012	belongs to the aldehyde dehydrogenase family
XPG1_1648	COG1454	alcohol dehydrogenase
XPG1_1649	COG4166	transmembrane transport
XPG1_1651	COG0601	transmembrane transport
XPG1_1652	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
XPG1_1653	COG0444	Belongs to the ABC transporter superfamily
XPG1_1654	COG4608	Belongs to the ABC transporter superfamily
XPG1_1655	COG3099	Belongs to the UPF0263 family
XPG1_1656	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPG1_1658	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
XPG1_1659	COG1607	acyl-coa hydrolase
XPG1_1660	COG2917	probably involved in intracellular septation
XPG1_1662	COG3047	cAMP biosynthetic process
XPG1_1663	COG0159	tryptophan synthase activity
XPG1_1664	COG0133	tryptophan synthase activity
XPG1_1666	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XPG1_1667	COG0512	Glutamine amidotransferase of anthranilate synthase
XPG1_1670	COG0009	L-threonylcarbamoyladenylate synthase
XPG1_1673	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_1674	COG0616	signal peptide processing
XPG1_1676	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XPG1_1677	COG0583	DNA-binding transcription factor activity
XPG1_1681	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
XPG1_1682	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XPG1_1683	COG0284	orotidine-5'-phosphate decarboxylase activity
XPG1_1684	COG0023	Translation Initiation Factor
XPG1_1686	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
XPG1_1687	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XPG1_1689	COG4659	FMN binding
XPG1_1690	COG4658	electron transport chain
XPG1_1691	COG4656	Part of a membrane complex involved in electron transport
XPG1_1693	COG4657	Part of a membrane complex involved in electron transport
XPG1_1694	COG0673	inositol 2-dehydrogenase activity
XPG1_1695	COG0385	Bile acid
XPG1_1696	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
XPG1_1697	COG5339	Protein conserved in bacteria
XPG1_1698	COG1482	cell wall glycoprotein biosynthetic process
XPG1_1699	COG0114	fumarate hydratase activity
XPG1_1702	COG2814	Major facilitator Superfamily
XPG1_1703	COG0583	DNA-binding transcription factor activity
XPG1_1706	COG1940	carbohydrate kinase activity
XPG1_1707	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XPG1_1710	COG4221	oxidoreductase activity
XPG1_1711	COG1132	(ABC) transporter
XPG1_1727	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XPG1_1727	COG2169	Transcriptional regulator
XPG1_1728	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
XPG1_1732	COG0583	DNA-binding transcription factor activity
XPG1_1734	COG1280	lysine exporter protein (LysE YggA)
XPG1_1737	COG4771	TonB-dependent receptor
XPG1_1740	COG0697	spore germination
XPG1_1742	COG0456	acetyltransferase
XPG1_1746	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPG1_1747	COG0589	response to stress
XPG1_1748	COG4974	Belongs to the 'phage' integrase family
XPG1_1753	COG0384	phenazine biosynthesis protein PhzF
XPG1_1754	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XPG1_1755	COG0477	Major facilitator Superfamily
XPG1_1756	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_1760	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
XPG1_1761	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
XPG1_1763	COG0531	amino acid
XPG1_1765	COG3121	Chaperone
XPG1_1770	COG1136	(ABC) transporter
XPG1_1770	COG0577	efflux transmembrane transporter activity
XPG1_1771	COG1136	(ABC) transporter
XPG1_1774	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
XPG1_1778	COG1643	Atp-dependent helicase
XPG1_1779	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
XPG1_1780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
XPG1_1783	COG2983	Belongs to the UPF0260 family
XPG1_1784	COG0179	Fumarylacetoacetate (FAA) hydrolase
XPG1_1785	COG2951	lytic endotransglycosylase activity
XPG1_1786	COG3100	YcgL domain-containing protein
XPG1_1788	COG0850	regulation of cytokinetic process
XPG1_1789	COG2894	cell division
XPG1_1790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
XPG1_1791	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
XPG1_1792	COG0318	PFAM AMP-dependent synthetase and ligase
XPG1_1794	COG1199	ATP-dependent helicase activity
XPG1_1795	COG0251	oxidation-reduction process
XPG1_1796	COG2076	Multidrug Resistance protein
XPG1_1797	COG2076	Multidrug Resistance protein
XPG1_1798	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XPG1_1800	COG1737	Transcriptional regulator
XPG1_1802	COG0469	pyruvate kinase activity
XPG1_1803	COG1560	Kdo2-lipid A biosynthetic process
XPG1_1804	COG0739	heme binding
XPG1_1805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
XPG1_1806	COG1121	(ABC) transporter
XPG1_1807	COG1108	ABC-type Mn2 Zn2 transport systems permease components
XPG1_1810	COG2255	four-way junction helicase activity
XPG1_1811	COG0632	four-way junction helicase activity
XPG1_1812	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XPG1_1813	COG0217	transcriptional regulatory protein
XPG1_1814	COG0494	nUDIX hydrolase
XPG1_1815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XPG1_1816	COG3788	relative of glutathione S-transferase, MAPEG superfamily
XPG1_1817	COG2226	methyltransferase
XPG1_1818	COG0500	methyltransferase
XPG1_1819	COG3142	Participates in the control of copper homeostasis
XPG1_1820	COG3102	Protein conserved in bacteria
XPG1_1821	COG0018	arginyl-trna synthetase
XPG1_1825	COG0477	Major facilitator Superfamily
XPG1_1828	COG3501	Rhs element vgr protein
XPG1_1849	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPG1_1851	COG3381	protein complex oligomerization
XPG1_1852	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XPG1_1858	COG5433	transposase activity
XPG1_1859	COG5433	transposase activity
XPG1_1864	COG2814	Major facilitator Superfamily
XPG1_1867	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_1868	COG5433	transposase activity
XPG1_1876	COG2378	regulation of single-species biofilm formation
XPG1_1884	COG0659	secondary active sulfate transmembrane transporter activity
XPG1_1885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XPG1_1886	COG2912	Transglutaminase-like superfamily
XPG1_1888	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XPG1_1889	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XPG1_1891	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XPG1_1892	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XPG1_1893	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XPG1_1897	COG0193	aminoacyl-tRNA hydrolase activity
XPG1_1898	COG0012	GTP binding
XPG1_1904	COG0579	oxidoreductase
XPG1_1906	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
XPG1_1908	COG1271	oxidase subunit
XPG1_1909	COG1294	oxidase, subunit
XPG1_1910	COG2356	endonuclease I
XPG1_1911	COG0589	response to stress
XPG1_1912	COG0589	response to stress
XPG1_1914	COG1335	isochorismatase
XPG1_1920	COG0531	amino acid
XPG1_1921	COG1982	Orn Lys Arg decarboxylase major
XPG1_1925	COG0076	glutamate decarboxylase activity
XPG1_1927	COG0583	DNA-binding transcription factor activity
XPG1_1928	COG1301	dicarboxylic acid transport
XPG1_1932	COG2084	Dehydrogenase
XPG1_1933	COG2814	Major facilitator Superfamily
XPG1_1934	COG5433	transposase activity
XPG1_1944	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_1947	COG1309	transcriptional regulator
XPG1_1951	COG0814	amino acid
XPG1_1952	COG2826	transposase and inactivated derivatives, IS30 family
XPG1_1958	COG1943	Transposase
XPG1_1970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XPG1_1996	COG3423	Transcriptional regulator
XPG1_1997	COG4626	Terminase
XPG1_1997	COG1802	Transcriptional regulator
XPG1_2024	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XPG1_2025	COG0322	excinuclease ABC activity
XPG1_2026	COG2197	response regulator
XPG1_2031	COG1113	amino acid transport
XPG1_2032	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPG1_2033	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XPG1_2033	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
XPG1_2033	COG0506	proline dehydrogenase activity
XPG1_2035	COG1191	sigma factor activity
XPG1_2042	COG1677	Flagellar hook-basal body complex protein FliE
XPG1_2043	COG1766	The M ring may be actively involved in energy transduction
XPG1_2044	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
XPG1_2046	COG1157	protein secretion by the type III secretion system
XPG1_2047	COG2882	bacterial-type flagellum organization
XPG1_2048	COG3144	bacterial-type flagellum assembly
XPG1_2049	COG1580	Controls the rotational direction of flagella during chemotaxis
XPG1_2054	COG1987	bacterial-type flagellum assembly
XPG1_2057	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
XPG1_2058	COG1256	bacterial-type flagellum assembly
XPG1_2060	COG1706	bacterial-type flagellum-dependent cell motility
XPG1_2061	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
XPG1_2063	COG4786	Flagellar basal body rod
XPG1_2065	COG1749	Flagellar hook protein flgE
XPG1_2066	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
XPG1_2067	COG1558	bacterial-type flagellum-dependent cell motility
XPG1_2068	COG1815	bacterial-type flagellum-dependent cell motility
XPG1_2073	COG3539	Fimbrial protein
XPG1_2074	COG3121	Chaperone
XPG1_2078	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XPG1_2079	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
XPG1_2080	COG1115	amino acid carrier protein
XPG1_2082	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
XPG1_2083	COG0745	RESPONSE REGULATOR receiver
XPG1_2084	COG2201	protein-glutamate methylesterase activity
XPG1_2085	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
XPG1_2086	COG0840	transmembrane signaling receptor activity
XPG1_2088	COG0835	chemotaxis
XPG1_2089	COG2198	Histidine kinase
XPG1_2089	COG0643	Histidine kinase
XPG1_2091	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
XPG1_2099	COG1285	pathogenesis
XPG1_2101	COG1278	Cold shock
XPG1_2107	COG0418	dihydroorotase activity
XPG1_2110	COG1560	Kdo2-lipid A biosynthetic process
XPG1_2117	COG1304	FMN binding
XPG1_2118	COG1620	l-lactate permease
XPG1_2120	COG3545	Serine hydrolase
XPG1_2122	COG5433	transposase activity
XPG1_2129	COG1733	regulation of RNA biosynthetic process
XPG1_2130	COG2814	Major facilitator Superfamily
XPG1_2131	COG0583	DNA-binding transcription factor activity
XPG1_2137	COG2920	part of a sulfur-relay system
XPG1_2139	COG1254	Belongs to the acylphosphatase family
XPG1_2140	COG3785	DNA binding
XPG1_2141	COG1832	CoA-binding protein
XPG1_2142	COG0210	DNA helicase
XPG1_2143	COG1289	transmembrane transporter activity
XPG1_2147	COG3070	regulator of competence-specific genes
XPG1_2148	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
XPG1_2150	COG3120	sequence-specific DNA binding
XPG1_2151	COG1067	ATP-dependent peptidase activity
XPG1_2152	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPG1_2153	COG3009	Protein conserved in bacteria
XPG1_2154	COG3008	intermembrane lipid transfer
XPG1_2154	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPG1_2155	COG2995	paraquat-inducible protein a
XPG1_2156	COG0488	(ABC) transporter
XPG1_2157	COG0116	Belongs to the methyltransferase superfamily
XPG1_2157	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XPG1_2158	COG3217	Mosc domain protein beta barrel domain protein
XPG1_2158	COG0633	Ferredoxin
XPG1_2161	COG0167	dihydroorotate dehydrogenase activity
XPG1_2170	COG2186	Transcriptional regulator
XPG1_2171	COG3734	2-keto-3-deoxy-galactonokinase
XPG1_2172	COG0800	Aldolase
XPG1_2173	COG4948	Mandelate Racemase Muconate Lactonizing
XPG1_2174	COG2271	Major facilitator Superfamily
XPG1_2175	COG0308	aminopeptidase N
XPG1_2176	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XPG1_2177	COG0017	Asparaginyl-tRNA synthetase
XPG1_2178	COG2801	Transposase and inactivated derivatives
XPG1_2179	COG2963	transposase activity
XPG1_2180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XPG1_2181	COG1448	Aminotransferase
XPG1_2182	COG2801	Transposase and inactivated derivatives
XPG1_2183	COG2963	transposase activity
XPG1_2185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XPG1_2186	COG3108	Peptidase M15
XPG1_2187	COG2989	Protein conserved in bacteria
XPG1_2189	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
XPG1_2190	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
XPG1_2191	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
XPG1_2192	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XPG1_2193	COG1434	Gram-negative-bacterium-type cell wall biogenesis
XPG1_2195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XPG1_2196	COG2835	tetraacyldisaccharide 4'-kinase activity
XPG1_2197	COG1663	tetraacyldisaccharide 4'-kinase activity
XPG1_2198	COG1132	(ABC) transporter
XPG1_2199	COG2333	competence protein COMEC
XPG1_2199	COG0658	competence protein
XPG1_2202	COG0539	negative regulation of cytoplasmic translation
XPG1_2203	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XPG1_2204	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XPG1_2205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XPG1_2206	COG0252	asparaginase activity
XPG1_2207	COG1944	ATP diphosphatase activity
XPG1_2208	COG2116	formate transmembrane transporter activity
XPG1_2209	COG1882	Formate acetyltransferase
XPG1_2211	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
XPG1_2215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XPG1_2216	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XPG1_2217	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XPG1_2218	COG3107	peptidoglycan biosynthetic process
XPG1_2218	COG1674	ftsk spoiiie
XPG1_2219	COG1522	sequence-specific DNA binding
XPG1_2221	COG0492	ferredoxin-NADP+ reductase activity
XPG1_2223	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
XPG1_2224	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XPG1_2227	COG0542	response to heat
XPG1_2228	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XPG1_2230	COG1278	Cold shock
XPG1_2231	COG1136	(ABC) transporter
XPG1_2231	COG0577	efflux transmembrane transporter activity
XPG1_2232	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_2233	COG2431	L-lysine efflux transmembrane transporter activity
XPG1_2234	COG1126	abc transporter atp-binding protein
XPG1_2235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_2236	COG4215	(ABC) transporter
XPG1_2237	COG4160	amino acid transport
XPG1_2238	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPG1_2242	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
XPG1_2243	COG0671	phosphoesterase, PA-phosphatase related
XPG1_2245	COG0814	amino acid
XPG1_2246	COG1686	Belongs to the peptidase S11 family
XPG1_2247	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPG1_2248	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XPG1_2249	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPG1_2249	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XPG1_2250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XPG1_2250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XPG1_2251	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XPG1_2251	COG0131	Imidazoleglycerol-phosphate dehydratase
XPG1_2252	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XPG1_2253	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XPG1_2254	COG0107	imidazoleglycerol-phosphate synthase activity
XPG1_2255	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XPG1_2255	COG0140	phosphoribosyl-ATP diphosphatase activity
XPG1_2256	COG1454	alcohol dehydrogenase
XPG1_2257	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
XPG1_2260	COG1253	flavin adenine dinucleotide binding
XPG1_2261	COG2982	Protein involved in outer membrane biogenesis
XPG1_2262	COG0717	Belongs to the dCTP deaminase family
XPG1_2263	COG0572	uridine kinase
XPG1_2265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPG1_2265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XPG1_2266	COG1380	Effector of murein hydrolase LrgA
XPG1_2267	COG1346	cytolysis
XPG1_2269	COG0281	malic enzyme
XPG1_2270	COG2949	membrane
XPG1_2271	COG2311	Membrane
XPG1_2272	COG0302	gtp cyclohydrolase
XPG1_2273	COG0477	Major facilitator Superfamily
XPG1_2276	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XPG1_2277	COG0488	(ABC) transporter
XPG1_2279	COG5006	permease, DMT superfamily
XPG1_2280	COG2824	Alkylphosphonate utilization operon protein PhnA
XPG1_2283	COG1199	ATP-dependent helicase activity
XPG1_2285	COG2897	thiosulfate sulfurtransferase activity
XPG1_2286	COG2261	transglycosylase associated protein
XPG1_2292	COG1535	isochorismatase
XPG1_2292	COG3433	isochorismatase activity
XPG1_2293	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_2298	COG3220	belongs to the UPF0276 family
XPG1_2301	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XPG1_2305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPG1_2306	COG0513	Belongs to the DEAD box helicase family
XPG1_2307	COG1309	transcriptional regulator
XPG1_2309	COG1131	(ABC) transporter
XPG1_2310	COG0842	Transport permease protein
XPG1_2311	COG0842	Transport permease protein
XPG1_2313	COG0670	Belongs to the BI1 family
XPG1_2314	COG0314	molybdopterin synthase activity
XPG1_2315	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
XPG1_2316	COG0315	cyclic pyranopterin monophosphate synthase activity
XPG1_2317	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
XPG1_2318	COG0391	Required for morphogenesis under gluconeogenic growth conditions
XPG1_2319	COG0556	nucleotide-excision repair
XPG1_2322	COG2226	methyltransferase
XPG1_2323	COG0156	8-amino-7-oxononanoate synthase activity
XPG1_2324	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XPG1_2327	COG2706	6-phosphogluconolactonase activity
XPG1_2328	COG0561	phosphatase activity
XPG1_2329	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
XPG1_2330	COG4149	molybdate abc transporter
XPG1_2331	COG0725	ABC transporter, periplasmic molybdate-binding protein
XPG1_2333	COG3585	molybdate ion transport
XPG1_2333	COG2005	Transcriptional regulator
XPG1_2334	COG1119	ATPase activity
XPG1_2336	COG1279	arginine transmembrane transporter activity
XPG1_2337	COG0588	phosphoglycerate mutase activity
XPG1_2338	COG2801	Transposase and inactivated derivatives
XPG1_2339	COG2963	transposase activity
XPG1_2340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPG1_2343	COG2814	Major facilitator Superfamily
XPG1_2344	COG0583	DNA-binding transcription factor activity
XPG1_2346	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
XPG1_2347	COG2885	chlorophyll binding
XPG1_2348	COG0823	Involved in the tonB-independent uptake of proteins
XPG1_2349	COG3064	Membrane
XPG1_2350	COG0848	biopolymer transport protein
XPG1_2351	COG0811	peptide transport
XPG1_2352	COG0824	Thioesterase
XPG1_2353	COG3790	cyd operon protein YbgE
XPG1_2354	COG1294	oxidase, subunit
XPG1_2355	COG1271	oxidase subunit
XPG1_2356	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XPG1_2357	COG0045	succinate-CoA ligase (ADP-forming) activity
XPG1_2358	COG0508	dehydrogenase complex catalyzes the overall conversion of
XPG1_2359	COG0567	Dehydrogenase, E1 component
XPG1_2360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XPG1_2361	COG1053	succinate dehydrogenase
XPG1_2362	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XPG1_2363	COG2009	succinate dehydrogenase
XPG1_2369	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
XPG1_2371	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
XPG1_2372	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
XPG1_2373	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
XPG1_2374	COG2205	protein histidine kinase activity
XPG1_2378	COG0033	Phosphoglucomutase
XPG1_2379	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
XPG1_2380	COG0596	Alpha beta hydrolase
XPG1_2381	COG2226	methyltransferase
XPG1_2385	COG1073	alpha beta
XPG1_2385	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
XPG1_2385	COG3064	Membrane
XPG1_2386	COG2994	toxin metabolic process
XPG1_2391	COG2274	protein secretion by the type I secretion system
XPG1_2392	COG2207	Transcriptional regulator
XPG1_2392	COG1917	Cupin 2, conserved barrel domain protein
XPG1_2394	COG0716	FMN binding
XPG1_2395	COG0735	belongs to the Fur family
XPG1_2396	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XPG1_2405	COG2190	(PTS) system
XPG1_2405	COG1263	PTS System
XPG1_2405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
XPG1_2407	COG0363	glucosamine-6-phosphate deaminase activity
XPG1_2408	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XPG1_2409	COG1846	Transcriptional regulator
XPG1_2409	COG1940	carbohydrate kinase activity
XPG1_2411	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XPG1_2412	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XPG1_2413	COG1702	phosphate starvation-inducible protein PhoH
XPG1_2414	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XPG1_2415	COG4535	Mg2 and Co2 transporter CorC
XPG1_2416	COG0815	Transfers the fatty acyl group on membrane lipoproteins
XPG1_2418	COG0765	amino acid transport
XPG1_2419	COG0765	amino acid transport
XPG1_2420	COG1126	abc transporter atp-binding protein
XPG1_2421	COG0495	leucyl-tRNA aminoacylation
XPG1_2422	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
XPG1_2423	COG1466	dna polymerase III delta subunit
XPG1_2425	COG0799	negative regulation of ribosome biogenesis
XPG1_2426	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XPG1_2427	COG0768	penicillin binding
XPG1_2428	COG0772	Belongs to the SEDS family
XPG1_2429	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XPG1_2430	COG1686	Belongs to the peptidase S11 family
XPG1_2431	COG2921	Belongs to the UPF0250 family
XPG1_2432	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
XPG1_2434	COG0321	lipoyl(octanoyl) transferase activity
XPG1_2435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XPG1_2436	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XPG1_2437	COG1278	Cold shock
XPG1_2438	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XPG1_2440	COG4175	Glycine betaine
XPG1_2441	COG4176	ABC-type proline glycine betaine transport system permease component
XPG1_2442	COG2113	Glycine betaine
XPG1_2444	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
XPG1_2445	COG1846	Transcriptional regulator
XPG1_2446	COG1566	PFAM secretion protein HlyD family protein
XPG1_2447	COG2814	Major facilitator Superfamily
XPG1_2448	COG4114	ferric iron reductase
XPG1_2449	COG1120	ATPase activity
XPG1_2452	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPG1_2455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
XPG1_2455	COG1042	CoA-binding domain protein
XPG1_2455	COG0045	succinate-CoA ligase (ADP-forming) activity
XPG1_2456	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XPG1_2462	COG0542	response to heat
XPG1_2464	COG0564	pseudouridine synthase activity
XPG1_2465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XPG1_2474	COG0287	Prephenate dehydrogenase
XPG1_2474	COG1605	Chorismate mutase
XPG1_2475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XPG1_2476	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XPG1_2477	COG0335	large ribosomal subunit rRNA binding
XPG1_2478	COG0336	Belongs to the RNA methyltransferase TrmD family
XPG1_2479	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XPG1_2481	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XPG1_2482	COG4137	Cytochrome C assembly protein
XPG1_2483	COG4536	flavin adenine dinucleotide binding
XPG1_2484	COG2918	glutathione biosynthetic process
XPG1_2486	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
XPG1_2487	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XPG1_2490	COG2814	Major facilitator Superfamily
XPG1_2491	COG0204	Acyl-transferase
XPG1_2491	COG0318	PFAM AMP-dependent synthetase and ligase
XPG1_2492	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XPG1_2493	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XPG1_2494	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XPG1_2497	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
XPG1_2500	COG2195	Cleaves the N-terminal amino acid of tripeptides
XPG1_2501	COG2814	Major facilitator Superfamily
XPG1_2502	COG0583	DNA-binding transcription factor activity
XPG1_2509	COG1629	transport
XPG1_2510	COG1595	DNA-templated transcription, initiation
XPG1_2511	COG2991	Protein conserved in bacteria
XPG1_2512	COG1477	protein flavinylation
XPG1_2514	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_2515	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_2516	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_2517	COG1805	sodium ion transport
XPG1_2518	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
XPG1_2519	COG3034	peptidoglycan biosynthetic process
XPG1_2520	COG0121	glutamine amidotransferase
XPG1_2521	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XPG1_2522	COG1960	acyl-CoA dehydrogenase activity
XPG1_2523	COG0019	diaminopimelate decarboxylase activity
XPG1_2524	COG0583	DNA-binding transcription factor activity
XPG1_2525	COG0583	DNA-binding transcription factor activity
XPG1_2530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XPG1_2531	COG0189	ligase activity
XPG1_2532	COG1678	Uncharacterized ACR, COG1678
XPG1_2533	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
XPG1_2534	COG2805	Type II/IV secretion system protein
XPG1_2535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XPG1_2536	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
XPG1_2537	COG0762	integral membrane protein
XPG1_2538	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XPG1_2539	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPG1_2540	COG0066	3-isopropylmalate dehydratase activity
XPG1_2541	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XPG1_2544	COG1881	PFAM PEBP family protein
XPG1_2545	COG4607	ABC-type enterochelin transport system periplasmic component
XPG1_2547	COG2066	Belongs to the glutaminase family
XPG1_2548	COG3171	Protein conserved in bacteria
XPG1_2549	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XPG1_2550	COG1194	a g-specific adenine glycosylase
XPG1_2551	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XPG1_2552	COG0741	lytic transglycosylase activity
XPG1_2553	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XPG1_2562	COG2808	Putative FMN-binding domain
XPG1_2569	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XPG1_2582	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XPG1_2586	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
XPG1_2590	COG1673	EVE domain
XPG1_2591	COG2814	Major facilitator Superfamily
XPG1_2613	COG3423	Transcriptional regulator
XPG1_2620	COG4372	Transposase
XPG1_2624	COG3385	transposase activity
XPG1_2629	COG4974	Belongs to the 'phage' integrase family
XPG1_2645	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_2650	COG2226	methyltransferase
XPG1_2660	COG0583	DNA-binding transcription factor activity
XPG1_2661	COG0667	Aldo Keto reductase
XPG1_2662	COG2814	Major facilitator Superfamily
XPG1_2666	COG1733	regulation of RNA biosynthetic process
XPG1_2667	COG0604	alcohol dehydrogenase
XPG1_2672	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
XPG1_2676	COG2963	transposase activity
XPG1_2685	COG4221	oxidoreductase activity
XPG1_2687	COG2801	Transposase and inactivated derivatives
XPG1_2688	COG2963	transposase activity
XPG1_2691	COG0583	DNA-binding transcription factor activity
XPG1_2698	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_2703	COG2814	Major facilitator Superfamily
XPG1_2704	COG1309	transcriptional regulator
XPG1_2709	COG0477	Major facilitator Superfamily
XPG1_2715	COG1960	acyl-CoA dehydrogenase activity
XPG1_2720	COG2814	Major facilitator Superfamily
XPG1_2724	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_2725	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_2728	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
XPG1_2729	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XPG1_2730	COG1605	Chorismate mutase
XPG1_2730	COG0077	Prephenate dehydratase
XPG1_2736	COG0716	FMN binding
XPG1_2737	COG0564	pseudouridine synthase activity
XPG1_2738	COG3098	single-species biofilm formation
XPG1_2740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPG1_2740	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XPG1_2741	COG1611	Belongs to the LOG family
XPG1_2742	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPG1_2748	COG2879	small protein
XPG1_2749	COG1966	Carbon starvation protein
XPG1_2750	COG2194	sulfuric ester hydrolase activity
XPG1_2759	COG3501	Rhs element vgr protein
XPG1_2760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XPG1_2763	COG4942	peptidase
XPG1_2763	COG1388	LysM domain
XPG1_2765	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XPG1_2766	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XPG1_2767	COG0585	pseudouridine synthase activity
XPG1_2768	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XPG1_2777	COG0529	Catalyzes the synthesis of activated sulfate
XPG1_2778	COG2895	sulfate adenylyltransferase (ATP) activity
XPG1_2779	COG0175	sulfate reduction
XPG1_2780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XPG1_2780	COG1648	precorrin-2 dehydrogenase activity
XPG1_2781	COG0175	sulfate reduction
XPG1_2782	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XPG1_2783	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XPG1_2784	COG0720	synthase
XPG1_2785	COG0602	queuosine metabolic process
XPG1_2787	COG3021	interspecies interaction between organisms
XPG1_2794	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XPG1_2795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XPG1_2797	COG1464	Belongs to the NlpA lipoprotein family
XPG1_2800	COG1720	tRNA m6t6A37 methyltransferase activity
XPG1_2801	COG0442	prolyl-tRNA aminoacylation
XPG1_2802	COG4568	rho-dependent transcription termination
XPG1_2803	COG0488	(ABC) transporter
XPG1_2807	COG0741	lytic transglycosylase activity
XPG1_2809	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XPG1_2810	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
XPG1_2811	COG0406	alpha-ribazole phosphatase activity
XPG1_2812	COG2207	Transcriptional regulator
XPG1_2812	COG3708	Transcriptional regulator
XPG1_2813	COG3045	CreA protein
XPG1_2814	COG0745	RESPONSE REGULATOR receiver
XPG1_2816	COG0083	homoserine kinase activity
XPG1_2818	COG3022	response to hydroperoxide
XPG1_2819	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
XPG1_2820	COG0521	Mo-molybdopterin cofactor biosynthetic process
XPG1_2822	COG1584	GPR1 FUN34 yaaH family protein
XPG1_2823	COG0443	Heat shock 70 kDa protein
XPG1_2824	COG0484	heat shock protein binding
XPG1_2828	COG2814	Major facilitator Superfamily
XPG1_2829	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
XPG1_2830	COG0583	DNA-binding transcription factor activity
XPG1_2832	COG0196	riboflavin kinase activity
XPG1_2833	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XPG1_2834	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XPG1_2835	COG1047	Peptidyl-prolyl cis-trans
XPG1_2836	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
XPG1_2837	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XPG1_2839	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XPG1_2844	COG3121	Chaperone
XPG1_2845	COG3188	usher protein
XPG1_2847	COG0813	purine-nucleoside phosphorylase activity
XPG1_2848	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
XPG1_2849	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
XPG1_2850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
XPG1_2851	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
XPG1_2852	COG0084	hydrolase, TatD family'
XPG1_2853	COG4667	esterase of the alpha-beta hydrolase superfamily
XPG1_2854	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XPG1_2856	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
XPG1_2858	COG2813	Specifically methylates the guanine in position
XPG1_2859	COG1785	Belongs to the alkaline phosphatase family
XPG1_2863	COG3423	Transcriptional regulator
XPG1_2864	COG2076	Multidrug Resistance protein
XPG1_2865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XPG1_2866	COG1509	lysine 2,3-aminomutase activity
XPG1_2868	COG0459	protein refolding
XPG1_2871	COG1027	Aspartate ammonia-lyase
XPG1_2877	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
XPG1_2879	COG4232	protein-disulfide reductase activity
XPG1_2880	COG1309	transcriptional regulator
XPG1_2881	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XPG1_2891	COG3547	Transposase (IS116 IS110 IS902 family)
XPG1_2909	COG4372	Transposase
XPG1_2920	COG3423	Transcriptional regulator
XPG1_2937	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_2943	COG2814	Major facilitator Superfamily
XPG1_2946	COG1309	transcriptional regulator
XPG1_2947	COG2814	Major facilitator Superfamily
XPG1_2949	COG0037	tRNA processing
XPG1_2950	COG0697	spore germination
XPG1_2952	COG0825	malonyl-CoA metabolic process
XPG1_2954	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XPG1_2955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_2956	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_2957	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XPG1_2958	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XPG1_2962	COG0750	zinc metalloprotease
XPG1_2963	COG0575	Belongs to the CDS family
XPG1_2964	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XPG1_2965	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XPG1_2966	COG0233	cytoplasmic translational termination
XPG1_2967	COG0528	UMP kinase activity
XPG1_2968	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XPG1_2969	COG0052	Belongs to the universal ribosomal protein uS2 family
XPG1_2970	COG0024	Methionine aminopeptidase
XPG1_2971	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
XPG1_2973	COG1126	abc transporter atp-binding protein
XPG1_2975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
XPG1_2976	COG0560	Phosphoserine phosphatase
XPG1_2977	COG3726	membrane protein affecting hemolysin expression
XPG1_2978	COG0656	L-ascorbic acid biosynthetic process
XPG1_2979	COG0586	Pfam SNARE associated Golgi protein
XPG1_2983	COG0811	peptide transport
XPG1_2984	COG0848	biopolymer transport protein
XPG1_2987	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
XPG1_2988	COG2974	May be involved in recombination
XPG1_2989	COG1940	carbohydrate kinase activity
XPG1_2990	COG0737	Belongs to the 5'-nucleotidase family
XPG1_2993	COG2132	Multicopper oxidase
XPG1_2994	COG0204	Acyl-transferase
XPG1_2995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
XPG1_2996	COG0187	DNA topoisomerase II activity
XPG1_2997	COG3150	esterase
XPG1_2998	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
XPG1_2999	COG0494	nUDIX hydrolase
XPG1_3000	COG1538	Outer membrane efflux protein
XPG1_3001	COG5463	Belongs to the UPF0441 family
XPG1_3002	COG0754	glutathionylspermidine amidase activity
XPG1_3003	COG3384	dioxygenase
XPG1_3004	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XPG1_3007	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
XPG1_3007	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
XPG1_3008	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
XPG1_3009	COG3025	triphosphatase activity
XPG1_3010	COG4991	sh3 domain protein
XPG1_3011	COG0617	tRNA 3'-terminal CCA addition
XPG1_3012	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XPG1_3013	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
XPG1_3015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XPG1_3017	COG0358	DNA primase activity
XPG1_3018	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XPG1_3019	COG1598	PFAM Uncharacterised protein family UPF0150
XPG1_3020	COG1724	mRNA binding
XPG1_3024	COG0215	cysteine-tRNA ligase activity
XPG1_3026	COG1396	sequence-specific DNA binding
XPG1_3027	COG1929	Belongs to the glycerate kinase type-1 family
XPG1_3029	COG2177	Part of the ABC transporter FtsEX involved in
XPG1_3030	COG2884	Cell division ATP-binding protein ftsE
XPG1_3031	COG0552	protein localization to endoplasmic reticulum
XPG1_3031	COG0552	protein localization to endoplasmic reticulum
XPG1_3032	COG0742	ribosomal rna small subunit methyltransferase
XPG1_3033	COG3776	membrane
XPG1_3036	COG0425	Belongs to the sulfur carrier protein TusA family
XPG1_3037	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
XPG1_3040	COG2271	Major facilitator Superfamily
XPG1_3041	COG0584	glycerophosphoryl diester phosphodiesterase
XPG1_3042	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XPG1_3044	COG1053	succinate dehydrogenase
XPG1_3045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XPG1_3046	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XPG1_3047	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
XPG1_3049	COG4770	biotin carboxylase activity
XPG1_3051	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
XPG1_3052	COG1914	H( )-stimulated, divalent metal cation uptake system
XPG1_3059	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
XPG1_3061	COG1739	Uncharacterized protein family UPF0029
XPG1_3062	COG0006	proline dipeptidase activity
XPG1_3063	COG1250	3-hydroxyacyl-CoA dehydrogenase
XPG1_3063	COG1024	Enoyl-CoA hydratase
XPG1_3064	COG0183	Belongs to the thiolase family
XPG1_3066	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
XPG1_3070	COG0805	protein transport
XPG1_3071	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPG1_3072	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XPG1_3073	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XPG1_3074	COG3165	ubiquinone biosynthetic process from chorismate
XPG1_3075	COG2226	methyltransferase
XPG1_3076	COG1322	Protein conserved in bacteria
XPG1_3077	COG0586	Pfam SNARE associated Golgi protein
XPG1_3079	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
XPG1_3080	COG2610	gluconate transmembrane transporter activity
XPG1_3084	COG3609	addiction module antidote protein, CC2985 family
XPG1_3097	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XPG1_3098	COG0583	DNA-binding transcription factor activity
XPG1_3099	COG0697	spore germination
XPG1_3100	COG0025	NhaP-type Na H and K H
XPG1_3101	COG2252	PERMEase
XPG1_3106	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XPG1_3110	COG1448	Aminotransferase
XPG1_3111	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XPG1_3112	COG0305	Participates in initiation and elongation during chromosome replication
XPG1_3115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPG1_3116	COG0735	belongs to the Fur family
XPG1_3118	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XPG1_3119	COG2937	Belongs to the GPAT DAPAT family
XPG1_3120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XPG1_3121	COG3161	chorismate lyase activity
XPG1_3122	COG0166	Belongs to the GPI family
XPG1_3124	COG0527	aspartate kinase activity
XPG1_3127	COG0800	Aldolase
XPG1_3128	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
XPG1_3129	COG2224	Isocitrate lyase
XPG1_3130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
XPG1_3131	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
XPG1_3138	COG0138	bifunctional purine biosynthesis protein purh
XPG1_3139	COG0151	Belongs to the GarS family
XPG1_3141	COG0776	regulation of translation
XPG1_3142	COG3068	Protein conserved in bacteria
XPG1_3143	COG1515	deoxyribonuclease V activity
XPG1_3144	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XPG1_3145	COG2816	NAD+ diphosphatase activity
XPG1_3147	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XPG1_3148	COG0352	thiamine-phosphate diphosphorylase activity
XPG1_3149	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XPG1_3150	COG2104	thiamine diphosphate biosynthetic process
XPG1_3151	COG2022	thiamine diphosphate biosynthetic process
XPG1_3154	COG2223	nitrite transmembrane transporter activity
XPG1_3155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
XPG1_3157	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
XPG1_3158	COG2909	trisaccharide binding
XPG1_3159	COG0058	SHG alpha-glucan phosphorylase activity
XPG1_3160	COG1640	4-alpha-glucanotransferase
XPG1_3161	COG3833	ABC-type maltose transport systems, permease component
XPG1_3162	COG1175	transmembrane transport
XPG1_3163	COG2182	Extracellular solute-binding protein
XPG1_3164	COG3842	ATPase activity
XPG1_3165	COG4580	involved in the transport of maltose and maltodextrins
XPG1_3167	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XPG1_3168	COG0085	RNA polymerase activity
XPG1_3169	COG0222	ribosome binding
XPG1_3170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XPG1_3171	COG0081	regulation of translation
XPG1_3172	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XPG1_3173	COG0250	Participates in transcription elongation, termination and antitermination
XPG1_3174	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XPG1_3175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPG1_3176	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XPG1_3177	COG0049	tRNA binding
XPG1_3178	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XPG1_3179	COG2168	tRNA wobble position uridine thiolation
XPG1_3180	COG2923	Belongs to the DsrF TusC family
XPG1_3181	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
XPG1_3182	COG2964	Protein conserved in bacteria
XPG1_3183	COG0545	Peptidyl-prolyl cis-trans isomerase
XPG1_3184	COG2900	Belongs to the SlyX family
XPG1_3185	COG1047	Peptidyl-prolyl cis-trans
XPG1_3187	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
XPG1_3189	COG0488	(ABC) transporter
XPG1_3190	COG0583	DNA-binding transcription factor activity
XPG1_3194	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
XPG1_3197	COG3089	Belongs to the UPF0270 family
XPG1_3198	COG3954	Phosphoribulokinase
XPG1_3199	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XPG1_3201	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XPG1_3202	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XPG1_3203	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPG1_3203	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
XPG1_3205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
XPG1_3206	COG3084	Protein conserved in bacteria
XPG1_3208	COG1763	Mo-molybdopterin cofactor biosynthetic process
XPG1_3210	COG0697	spore germination
XPG1_3211	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPG1_3212	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XPG1_3224	COG3547	Transposase (IS116 IS110 IS902 family)
XPG1_3227	COG4372	Transposase
XPG1_3229	COG3209	COG3209 Rhs family protein
XPG1_3230	COG4974	Belongs to the 'phage' integrase family
XPG1_3231	COG0358	DNA primase activity
XPG1_3232	COG2932	Transcriptional regulator
XPG1_3235	COG3209	COG3209 Rhs family protein
XPG1_3235	COG4104	PAAR repeat-containing protein
XPG1_3238	COG3501	Rhs element vgr protein
XPG1_3240	COG2175	clavaminate synthase activity
XPG1_3243	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XPG1_3244	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XPG1_3246	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
XPG1_3247	COG0494	nUDIX hydrolase
XPG1_3248	COG4143	(ABC) transporter
XPG1_3249	COG1178	ABC-type Fe3 transport system permease component
XPG1_3250	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
XPG1_3253	COG5433	transposase activity
XPG1_3255	COG2990	Protein conserved in bacteria
XPG1_3257	COG0446	pyridine nucleotide-disulphide oxidoreductase
XPG1_3257	COG1902	pentaerythritol trinitrate reductase activity
XPG1_3258	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
XPG1_3259	COG0586	Pfam SNARE associated Golgi protein
XPG1_3263	COG2814	Major facilitator Superfamily
XPG1_3267	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XPG1_3268	COG0673	inositol 2-dehydrogenase activity
XPG1_3271	COG4575	ribosome binding
XPG1_3272	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
XPG1_3274	COG2259	Doxx family
XPG1_3275	COG0583	DNA-binding transcription factor activity
XPG1_3276	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XPG1_3278	COG0792	nuclease activity
XPG1_3279	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
XPG1_3280	COG2823	Periplasmic or secreted lipoprotein
XPG1_3281	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XPG1_3282	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
XPG1_3283	COG5002	protein histidine kinase activity
XPG1_3283	COG2198	Histidine kinase
XPG1_3283	COG0784	Response regulator, receiver
XPG1_3284	COG0067	glutamate synthase
XPG1_3284	COG0070	glutamate synthase
XPG1_3284	COG0069	glutamate synthase activity
XPG1_3285	COG0493	'glutamate synthase
XPG1_3287	COG2969	positive regulation of protein catabolic process
XPG1_3288	COG0625	glutathione transferase activity
XPG1_3289	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XPG1_3290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XPG1_3291	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XPG1_3292	COG3105	Protein conserved in bacteria
XPG1_3293	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPG1_3294	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XPG1_3295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XPG1_3296	COG5007	Belongs to the BolA IbaG family
XPG1_3298	COG2854	intermembrane phospholipid transfer
XPG1_3299	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XPG1_3300	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XPG1_3301	COG1127	ABC transporter
XPG1_3302	COG0530	calcium, potassium:sodium antiporter activity
XPG1_3303	COG0517	IMP dehydrogenase activity
XPG1_3303	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
XPG1_3304	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XPG1_3305	COG3117	lipopolysaccharide transmembrane transporter activity
XPG1_3306	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
XPG1_3307	COG1137	ATPase activity
XPG1_3308	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
XPG1_3310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_3311	COG1660	Displays ATPase and GTPase activities
XPG1_3312	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XPG1_3316	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPG1_3317	COG0312	modulator of DNA gyrase
XPG1_3318	COG3028	Belongs to the UPF0307 family
XPG1_3327	COG0312	modulator of DNA gyrase
XPG1_3328	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XPG1_3329	COG3164	Protein of unknown function
XPG1_3330	COG1530	ribonuclease E activity
XPG1_3331	COG0424	maF-like protein
XPG1_3332	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XPG1_3333	COG1792	Involved in formation and maintenance of cell shape
XPG1_3334	COG1077	Cell shape determining protein MreB Mrl
XPG1_3335	COG0604	alcohol dehydrogenase
XPG1_3336	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XPG1_3337	COG0511	ligase activity, forming carbon-carbon bonds
XPG1_3338	COG0439	Biotin carboxylase
XPG1_3339	COG3924	membrane
XPG1_3340	COG4145	pantothenate transmembrane transporter activity
XPG1_3341	COG2264	protein methyltransferase activity
XPG1_3342	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XPG1_3343	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XPG1_3345	COG0477	Major facilitator Superfamily
XPG1_3349	COG0583	DNA-binding transcription factor activity
XPG1_3350	COG1470	cell adhesion involved in biofilm formation
XPG1_3350	COG1388	LysM domain
XPG1_3352	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XPG1_3355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_3361	COG0765	amino acid transport
XPG1_3362	COG1126	abc transporter atp-binding protein
XPG1_3363	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
XPG1_3364	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
XPG1_3365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XPG1_3366	COG0626	cystathionine gamma-synthase activity
XPG1_3367	COG1757	Na H antiporter
XPG1_3368	COG2515	1-aminocyclopropane-1-carboxylate deaminase
XPG1_3372	COG1846	Transcriptional regulator
XPG1_3374	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
XPG1_3375	COG0564	pseudouridine synthase activity
XPG1_3376	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
XPG1_3377	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XPG1_3378	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XPG1_3379	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XPG1_3380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XPG1_3381	COG2967	ApaG domain
XPG1_3382	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XPG1_3383	COG0513	Belongs to the DEAD box helicase family
XPG1_3386	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XPG1_3387	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XPG1_3388	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XPG1_3389	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XPG1_3390	COG0195	Participates in both transcription termination and antitermination
XPG1_3391	COG0779	Required for maturation of 30S ribosomal subunits
XPG1_3392	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XPG1_3393	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XPG1_3394	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XPG1_3395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XPG1_3396	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XPG1_3397	COG1534	Rna-binding protein
XPG1_3398	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XPG1_3399	COG2027	D-alanyl-D-alanine carboxypeptidase
XPG1_3400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XPG1_3401	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XPG1_3402	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XPG1_3404	COG0142	geranyltranstransferase activity
XPG1_3407	COG3423	Transcriptional regulator
XPG1_3408	COG0039	L-malate dehydrogenase activity
XPG1_3410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XPG1_3411	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
XPG1_3414	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XPG1_3415	COG2105	PFAM AIG2 family protein
XPG1_3416	COG2911	Protein conserved in bacteria
XPG1_3418	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XPG1_3419	COG1253	flavin adenine dinucleotide binding
XPG1_3421	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
XPG1_3423	COG0545	Peptidyl-prolyl cis-trans isomerase
XPG1_3424	COG0359	binds to the 23S rRNA
XPG1_3426	COG0360	Binds together with S18 to 16S ribosomal RNA
XPG1_3427	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XPG1_3428	COG0557	exoribonuclease II activity
XPG1_3429	COG1959	2 iron, 2 sulfur cluster binding
XPG1_3430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XPG1_3431	COG0330	HflC and HflK could
XPG1_3432	COG0330	HflC and HflK could
XPG1_3434	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XPG1_3435	COG1923	regulation of RNA biosynthetic process
XPG1_3436	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XPG1_3437	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XPG1_3438	COG0860	N-Acetylmuramoyl-L-alanine amidase
XPG1_3439	COG0802	atpase or kinase
XPG1_3440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XPG1_3444	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XPG1_3445	COG1162	GTPase activity
XPG1_3446	COG0688	phosphatidylethanolamine metabolic process
XPG1_3447	COG1511	domain protein
XPG1_3447	COG3264	Mechanosensitive ion channel
XPG1_3448	COG0561	phosphatase activity
XPG1_3449	COG2267	carboxylic ester hydrolase activity
XPG1_3450	COG0514	ATP-dependent DNA helicase (RecQ)
XPG1_3451	COG2050	protein possibly involved in aromatic compounds catabolism
XPG1_3454	COG2814	Major facilitator Superfamily
XPG1_3455	COG0583	DNA-binding transcription factor activity
XPG1_3456	COG1192	Involved in chromosome partitioning
XPG1_3457	COG0598	Magnesium transport protein CorA
XPG1_3459	COG1011	Hydrolase
XPG1_3462	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XPG1_3463	COG5567	small periplasmic lipoprotein
XPG1_3464	COG1965	Belongs to the frataxin family
XPG1_3466	COG0181	hydroxymethylbilane synthase activity
XPG1_3468	COG2959	enzyme of heme biosynthesis
XPG1_3469	COG3071	HemY protein
XPG1_3472	COG1113	amino acid transport
XPG1_3473	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XPG1_3475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XPG1_3476	COG2244	polysaccharide biosynthetic process
XPG1_3477	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XPG1_3478	COG0456	acetyltransferase
XPG1_3479	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
XPG1_3480	COG1088	dTDP-glucose 4,6-dehydratase activity
XPG1_3481	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XPG1_3482	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
XPG1_3483	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
XPG1_3484	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XPG1_3485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XPG1_3486	COG3118	belongs to the thioredoxin family
XPG1_3487	COG0513	Belongs to the DEAD box helicase family
XPG1_3488	COG0248	Ppx GppA phosphatase
XPG1_3490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XPG1_3491	COG0583	DNA-binding transcription factor activity
XPG1_3493	COG0129	dihydroxy-acid dehydratase activity
XPG1_3494	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XPG1_3495	COG3978	acetolactate synthase activity
XPG1_3497	COG0606	chelatase, subunit chli
XPG1_3498	COG3085	chromosome segregation
XPG1_3499	COG0583	DNA-binding transcription factor activity
XPG1_3505	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XPG1_3507	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XPG1_3508	COG0009	L-threonylcarbamoyladenylate synthase
XPG1_3509	COG0551	DNA topoisomerase type I activity
XPG1_3510	COG0758	DNA mediated transformation
XPG1_3512	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XPG1_3513	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XPG1_3513	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XPG1_3514	COG0569	domain protein
XPG1_3516	COG3036	rescue of stalled ribosome
XPG1_3517	COG0789	Transcriptional regulator
XPG1_3518	COG0203	ribosomal protein L17
XPG1_3519	COG0202	RNA polymerase activity
XPG1_3520	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XPG1_3522	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XPG1_3523	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XPG1_3524	COG0201	protein transport
XPG1_3525	COG0200	Binds to the 23S rRNA
XPG1_3526	COG1841	ribosomal large subunit assembly
XPG1_3527	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XPG1_3528	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XPG1_3529	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XPG1_3530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XPG1_3531	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XPG1_3532	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XPG1_3533	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XPG1_3534	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XPG1_3535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XPG1_3536	COG0255	Belongs to the universal ribosomal protein uL29 family
XPG1_3537	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
XPG1_3539	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XPG1_3540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XPG1_3541	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XPG1_3542	COG0089	rRNA binding
XPG1_3543	COG0088	Forms part of the polypeptide exit tunnel
XPG1_3544	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XPG1_3545	COG0051	transcription antitermination factor activity, RNA binding
XPG1_3547	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XPG1_3549	COG1072	(Pantothenic acid kinase))
XPG1_3550	COG2801	Transposase and inactivated derivatives
XPG1_3551	COG2963	transposase activity
XPG1_3553	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XPG1_3561	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
XPG1_3562	COG4206	TonB-dependent receptor
XPG1_3563	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XPG1_3565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XPG1_3568	COG0165	Argininosuccinate lyase
XPG1_3569	COG0137	argininosuccinate synthase activity
XPG1_3570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XPG1_3571	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XPG1_3572	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XPG1_3574	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
XPG1_3575	COG0460	homoserine dehydrogenase
XPG1_3575	COG0527	aspartate kinase activity
XPG1_3576	COG0626	cystathionine gamma-synthase activity
XPG1_3579	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XPG1_3580	COG1609	Transcriptional regulator
XPG1_3581	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
XPG1_3582	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
XPG1_3583	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XPG1_3584	COG1575	Belongs to the MenA family. Type 1 subfamily
XPG1_3585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
XPG1_3586	COG3074	FtsZ-dependent cytokinesis
XPG1_3588	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XPG1_3590	COG3152	Membrane
XPG1_3592	COG0149	triose-phosphate isomerase activity
XPG1_3593	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
XPG1_3595	COG0205	6-phosphofructokinase activity
XPG1_3596	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
XPG1_3600	COG0745	RESPONSE REGULATOR receiver
XPG1_3601	COG2205	protein histidine kinase activity
XPG1_3602	COG1088	dTDP-glucose 4,6-dehydratase activity
XPG1_3615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
XPG1_3618	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XPG1_3619	COG1045	serine acetyltransferase
XPG1_3620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XPG1_3621	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XPG1_3622	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XPG1_3623	COG4942	peptidase
XPG1_3625	COG2861	carbohydrate metabolic process
XPG1_3626	COG1063	alcohol dehydrogenase
XPG1_3627	COG0156	8-amino-7-oxononanoate synthase activity
XPG1_3628	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XPG1_3632	COG0859	PFAM glycosyl transferase family 9
XPG1_3634	COG0859	PFAM glycosyl transferase family 9
XPG1_3636	COG0297	glycogen (starch) synthase activity
XPG1_3636	COG0438	transferase activity, transferring glycosyl groups
XPG1_3637	COG1519	Transferase
XPG1_3639	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XPG1_3640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XPG1_3642	COG0438	transferase activity, transferring glycosyl groups
XPG1_3645	COG0438	transferase activity, transferring glycosyl groups
XPG1_3646	COG0267	Belongs to the bacterial ribosomal protein bL33 family
XPG1_3648	COG2003	Belongs to the UPF0758 family
XPG1_3650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XPG1_3651	COG0756	dUTP diphosphatase activity
XPG1_3652	COG1309	transcriptional regulator
XPG1_3653	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XPG1_3654	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XPG1_3655	COG1561	YicC-like family, N-terminal region
XPG1_3656	COG0582	viral genome integration into host DNA
XPG1_3674	COG5433	transposase activity
XPG1_3676	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
XPG1_3679	COG1368	sulfuric ester hydrolase activity
XPG1_3680	COG3276	selenocysteine insertion sequence binding
XPG1_3681	COG1921	L-seryl-tRNASec selenium transferase activity
XPG1_3682	COG3058	Necessary for formate dehydrogenase activity
XPG1_3684	COG0733	neurotransmitter:sodium symporter activity
XPG1_3685	COG2864	formate dehydrogenase
XPG1_3690	COG3383	formate dehydrogenase (NAD+) activity
XPG1_3690	COG0243	molybdopterin cofactor binding
XPG1_3692	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
XPG1_3694	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
XPG1_3702	COG2249	NAD(P)H dehydrogenase (quinone) activity
XPG1_3703	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_3704	COG1028	Short-chain dehydrogenase reductase Sdr
XPG1_3707	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XPG1_3710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
XPG1_3711	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XPG1_3712	COG0706	membrane insertase activity
XPG1_3713	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XPG1_3714	COG0594	ribonuclease P activity
XPG1_CDS2277925R	COG4890	Cyd operon protein YbgT