locus-tag	class	description
ET495_00010	ENOG4108IUX	(ABC) transporter
ET495_00015	ENOG41067SE	Tetr family transcriptional regulator
ET495_00025	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
ET495_00030	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
ET495_00040	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
ET495_00045	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
ET495_00065	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET495_00075	ENOG4107EF8	Glycosyl transferase (Group 1
ET495_00115	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
ET495_00130	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
ET495_00140	ENOG4105C19	ABC transporter
ET495_00150	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
ET495_00170	ENOG4105C87	Aminotransferase class I and II
ET495_00270	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
ET495_00275	ENOG4105DEI	Mannitol dehydrogenase
ET495_00290	ENOG4105D2H	Uronic isomerase
ET495_00295	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
ET495_00315	ENOG41089UC	methyltransferase, type 11
ET495_00320	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
ET495_00335	ENOG4105C7B	Threonine dehydratase
ET495_00340	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
ET495_00350	ENOG4105T1M	mycothiol conjugate amidase mca
ET495_00355	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
ET495_00365	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ET495_00370	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
ET495_00395	ENOG4105C3G	gtp-binding protein
ET495_00415	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_00445	ENOG4108JQ6	ABC transporter
ET495_00450	ENOG4105CI3	gtp-binding protein typa
ET495_00455	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
ET495_00475	ENOG4105CQC	Prephenate dehydratase
ET495_00490	ENOG4108Z4U	Ferredoxin
ET495_00520	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
ET495_00540	ENOG4107ZBN	O-methyltransferase
ET495_00555	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
ET495_00560	ENOG4105C31	Tryptophanyl-tRNA synthetase
ET495_00605	ENOG4105E33	succinate dehydrogenase
ET495_00625	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
ET495_00635	ENOG4105DIH	basic membrane
ET495_00645	ENOG4105UIB	(ABC) transporter
ET495_00675	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
ET495_00710	ENOG410650H	(LipO)protein
ET495_00735	ENOG4108JIK	carboxylase
ET495_00740	ENOG4107WR6	Maf-like protein
ET495_00745	ENOG4105RK9	auxin efflux carrier
ET495_00765	ENOG4105D8K	carboxyl transferase
ET495_00785	ENOG4108KGH	TRANSCRIPTIONal
ET495_00825	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
ET495_00835	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
ET495_00845	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
ET495_00860	ENOG4105E2R	ROK family
ET495_00880	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
ET495_00885	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
ET495_00905	ENOG4105E2V	Glycosyltransferase 36
ET495_00910	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
ET495_00915	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
ET495_00925	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
ET495_00945	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
ET495_00960	ENOG41080RH	Thioredoxin
ET495_00965	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
ET495_00985	ENOG4105D82	Glutamate dehydrogenase
ET495_01005	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
ET495_01040	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ET495_01050	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_01055	ENOG4105CPF	Cell wall formation (By similarity)
ET495_01075	ENOG4105VB9	50S ribosomal protein l28
ET495_01080	ENOG4105DP4	dak2 domain fusion protein ylov
ET495_01090	ENOG4106H78	methyltransferase
ET495_01095	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
ET495_01110	ENOG41084BZ	50S ribosomal protein L32
ET495_01115	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
ET495_01120	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
ET495_01130	ENOG4108JJ8	(ABC) transporter
ET495_01135	ENOG4108JJ9	ABC, transporter
ET495_01140	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
ET495_01145	ENOG4105C4M	(Ubiquinol oxidase) subunit I
ET495_01155	ENOG4105C03	ribonuclease
ET495_01160	ENOG4107T8J	thymidine kinase
ET495_01170	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
ET495_01175	ENOG4105K46	50S ribosomal protein l27
ET495_01180	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ET495_01190	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
ET495_01200	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
ET495_01205	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
ET495_01215	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
ET495_01220	ENOG4105CVJ	phosphoglycerate mutase
ET495_01250	ENOG4105CHR	reductase
ET495_01255	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_01285	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
ET495_01335	ENOG4105C26	Dehydrogenase
ET495_01340	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
ET495_01345	ENOG4107RSM	transcriptional regulator
ET495_01355	ENOG4105E5Q	amino acid AbC transporter
ET495_01360	ENOG4108JEH	abc transporter atp-binding protein
ET495_01365	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
ET495_01370	ENOG4105EHG	Permease protein
ET495_01375	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
ET495_01400	ENOG4105C10	Electron transfer flavoprotein
ET495_01420	ENOG4107QN1	sodium solute
ET495_01430	ENOG4105E2D	ec 3.2.1.52
ET495_01440	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
ET495_01465	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_01600	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
ET495_01625	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
ET495_01645	ENOG4105CI1	PTS System
ET495_01650	ENOG4105D8X	mechanosensitive ion channel
ET495_01715	ENOG4105D7W	serine acetyltransferase
ET495_01725	ENOG4105DCT	glycerol dehydrogenase
ET495_01750	ENOG4105DIV	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)
ET495_01815	ENOG4107HP6	Transcriptional regulator
ET495_01830	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
ET495_01835	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_01840	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_01845	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
ET495_01850	ENOG4108IQE	Amp-dependent synthetase and ligase
ET495_01855	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
ET495_01870	ENOG4105EAB	amino acid AbC transporter
ET495_01875	ENOG4105DRP	amino acid AbC transporter
ET495_01880	ENOG4105CDA	abc transporter atp-binding protein
ET495_01890	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
ET495_01940	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
ET495_01945	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
ET495_01950	ENOG4105CMT	Dihydroxyacetone kinase
ET495_01970	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
ET495_01985	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
ET495_02015	ENOG4105K5M	30s ribosomal protein S16
ET495_02020	ENOG41082KU	UPF0109 protein
ET495_02025	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
ET495_02030	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
ET495_02035	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
ET495_02040	ENOG4107QYR	Signal peptidase i
ET495_02045	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
ET495_02055	ENOG41080R2	UPF0102 protein
ET495_02060	ENOG4105C0P	Mg chelatase subunit ChlI
ET495_02070	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
ET495_02080	ENOG4105CE9	30S ribosomal protein S2
ET495_02085	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
ET495_02090	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
ET495_02095	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
ET495_02125	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
ET495_02135	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
ET495_02140	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
ET495_02150	ENOG4105DZP	Membrane-associated zinc metalloprotease
ET495_02155	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
ET495_02175	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ET495_02185	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
ET495_02205	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
ET495_02210	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
ET495_02225	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
ET495_02230	ENOG4108RH7	phosphoglycerate mutase
ET495_02235	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_02270	ENOG4108QIU	Dehydrogenase
ET495_02280	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
ET495_02285	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
ET495_02290	ENOG4105C1V	Peptidase, M16
ET495_02295	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
ET495_02315	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
ET495_02365	ENOG4105CEV	competence damage-inducible protein
ET495_02370	ENOG4105WBV	Transcriptional regulator
ET495_02395	ENOG4107KFM	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
ET495_02400	ENOG4105KC9	Modulates RecA activity (By similarity)
ET495_02405	ENOG4105DRP	amino acid AbC transporter
ET495_02410	ENOG4108Q1T	ABC transporter
ET495_02415	ENOG4107UBR	Extracellular solute-binding protein family 3
ET495_02420	ENOG4105CDA	abc transporter atp-binding protein
ET495_02425	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
ET495_02455	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
ET495_02460	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
ET495_02465	ENOG4107Y49	methyltransferase
ET495_02470	ENOG41069M3	Transcriptional regulator
ET495_02485	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
ET495_02500	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
ET495_02505	ENOG41067Z0	domain protein
ET495_02510	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
ET495_02515	ENOG4108JQ1	Dehydrogenase
ET495_02530	ENOG4105VEQ	Cold shock protein
ET495_02545	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
ET495_02565	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_02570	ENOG4108V6E	Cell division protein mraZ
ET495_02575	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
ET495_02585	ENOG4105CJN	penicillin-binding protein
ET495_02600	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
ET495_02605	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
ET495_02615	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
ET495_02620	ENOG4105DFU	Cell wall formation (By similarity)
ET495_02630	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
ET495_02640	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
ET495_02650	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
ET495_02655	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ET495_02675	ENOG4105C0B	DNA polymerase III (alpha subunit)
ET495_02690	ENOG4105WQ3	Rna-binding protein
ET495_02695	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
ET495_02705	ENOG4107XR4	alpha beta
ET495_02725	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
ET495_02735	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
ET495_02765	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
ET495_02770	ENOG41084BS	50S ribosomal protein L35
ET495_02775	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
ET495_02780	ENOG4105C2N	RNA methyltransferase TrmH family group 3
ET495_02790	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
ET495_02800	ENOG4105DT9	hydrolase family 43
ET495_02810	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
ET495_02815	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
ET495_02820	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
ET495_02825	ENOG4105CAS	nag kinase
ET495_02830	ENOG4105C8Y	Acetylornithine aminotransferase
ET495_02840	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
ET495_02845	ENOG4105CH7	arginosuccinase
ET495_02855	ENOG4108VX5	3-methyladenine DNA glycosylase
ET495_02910	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
ET495_02935	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
ET495_02985	ENOG4105JRK	feS assembly protein SufD
ET495_02995	ENOG4105C3K	feS assembly ATPase SufC
ET495_03005	ENOG4108UNV	SUF system FeS assembly protein, NifU family
ET495_03010	ENOG4105VG1	fes assembly suf system protein
ET495_03035	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
ET495_03040	ENOG4105E0A	ABC, transporter
ET495_03050	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
ET495_03080	ENOG4105KDC	50s ribosomal protein l28
ET495_03085	ENOG4105W0E	50S ribosomal protein L33
ET495_03090	ENOG41080FR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ET495_03095	ENOG4105NRA	50s ribosomal protein l31 type b
ET495_03100	ENOG4108638	50S ribosomal protein L36
ET495_03120	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ET495_03165	ENOG4105C5H	ABC transporter
ET495_03225	ENOG4105DKW	ABC transporter
ET495_03285	ENOG4108V1U	phospholipid-binding protein
ET495_03380	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
ET495_03425	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
ET495_03490	ENOG4107ZVI	PhiRv2 prophage protein
ET495_03520	ENOG4105C5H	ABC transporter
ET495_03525	ENOG4105CHJ	isochorismatase hydrolase
ET495_03530	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
ET495_03540	ENOG4105DGW	oligopeptidase A
ET495_03545	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET495_03560	ENOG4107SET	aldo keto reductase
ET495_03570	ENOG4105C8N	cysteinyl-tRNA synthetase
ET495_03600	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
ET495_03605	ENOG4105E5F	proteasome
ET495_03610	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
ET495_03615	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
ET495_03625	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
ET495_03640	ENOG4105BZ1	(ABC) transporter
ET495_03645	ENOG4105BZ1	(ABC) transporter
ET495_03650	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
ET495_03670	ENOG4105DK0	Indole-3-glycerol phosphate synthase
ET495_03675	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
ET495_03680	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
ET495_03685	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
ET495_03690	ENOG4105CBC	glutamate synthase
ET495_03745	ENOG4108YRB	methyltransferase
ET495_03755	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
ET495_03780	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
ET495_03805	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
ET495_03830	ENOG4105E5G	Alpha beta hydrolase fold
ET495_03870	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
ET495_03875	ENOG4105CHW	UPF0052 protein
ET495_03880	ENOG4108IQE	Amp-dependent synthetase and ligase
ET495_03890	ENOG4105CIE	May be required for sporulation (By similarity)
ET495_03895	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
ET495_03900	ENOG4105BZA	Phosphoglycerate kinase
ET495_03920	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
ET495_03935	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
ET495_03945	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
ET495_03960	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
ET495_03965	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
ET495_04065	ENOG4105EGI	Transcriptional regulator
ET495_04100	ENOG4105DA5	(ABC) transporter
ET495_04110	ENOG4105CJ1	ABC, transporter
ET495_04120	ENOG4105C0A	alcohol dehydrogenase
ET495_04180	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
ET495_04190	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
ET495_04195	ENOG4105D2B	acyl-CoA dehydrogenase
ET495_04205	ENOG4105CHR	reductase
ET495_04210	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_04225	ENOG4105CSH	Transporter
ET495_04240	ENOG4105CEU	Arginine dihydrolase
ET495_04245	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_04260	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
ET495_04265	ENOG4107SZ9	Hydantoinase oxoprolinase
ET495_04270	ENOG4105RQI	acetone carboxylase gamma subunit
ET495_04275	ENOG4107RID	5-oxoprolinase (ATP-hydrolyzing)
ET495_04320	ENOG4108UIN	ybak prolyl-trna synthetase associated region
ET495_04325	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_04335	ENOG4105CHR	reductase
ET495_04340	ENOG4105E98	transcriptional regulator DeoR family
ET495_04355	ENOG4105DM4	PTS System
ET495_04370	ENOG4105CJW	magnesium transporter
ET495_04375	ENOG410834F	Transcriptional regulator
ET495_04400	ENOG4105DRP	amino acid AbC transporter
ET495_04405	ENOG4105E5Q	amino acid AbC transporter
ET495_04435	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ET495_04460	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_04470	ENOG4107RWR	Sodium hydrogen exchanger
ET495_04515	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
ET495_04530	ENOG4105BZ1	(ABC) transporter
ET495_04535	ENOG4105BZ1	(ABC) transporter
ET495_04540	ENOG4107R3N	Filamentation induced by cAMP protein fic
ET495_04545	ENOG4105DND	Transcriptional regulator
ET495_04550	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
ET495_04565	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
ET495_04575	ENOG4108ZBR	Gcn5-related n-acetyltransferase
ET495_04580	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
ET495_04595	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_04615	ENOG4108FFZ	Transcriptional regulator
ET495_04630	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
ET495_04635	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
ET495_04655	ENOG4105CI2	imidazolone-5-propionate hydrolase
ET495_04665	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
ET495_04680	ENOG4108UZX	fmn reductase
ET495_04705	ENOG4105CDH	Citrulline--aspartate ligase
ET495_04725	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
ET495_04770	ENOG4108UW8	fha domain-containing protein
ET495_04805	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
ET495_04810	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
ET495_04815	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
ET495_04820	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
ET495_04825	ENOG4108R6K	riboflavin synthase, subunit alpha
ET495_04835	ENOG4105DJV	ribulose-phosphate 3-epimerase
ET495_04845	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
ET495_04860	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
ET495_04870	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
ET495_04875	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
ET495_04880	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
ET495_04890	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
ET495_04895	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
ET495_04900	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
ET495_04910	ENOG4105CD3	dihydroorotase
ET495_04915	ENOG4105CXT	aspartate transcarbamylase
ET495_04920	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
ET495_04925	ENOG410803B	Involved in the transcription termination process (By similarity)
ET495_04930	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
ET495_04945	ENOG4107VXZ	Hydrolase
ET495_04950	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
ET495_04965	ENOG4105DMF	Dehydrogenase
ET495_04985	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
ET495_04990	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
ET495_04995	ENOG4105E2X	shikimate dehydrogenase
ET495_05000	ENOG4105HHA	aminodeoxychorismate lyase
ET495_05010	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
ET495_05030	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
ET495_05040	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_05045	ENOG4107R5G	Periplasmic binding protein LacI transcriptional regulator
ET495_05050	ENOG4105CNN	ABC, transporter
ET495_05055	ENOG4105C2J	ABC transporter
ET495_05070	ENOG4105C9M	aspartyl-trna synthetase
ET495_05080	ENOG4105CUT	histidyl-tRNA synthetase
ET495_05115	ENOG4105C99	atpase involved in dna repair
ET495_05125	ENOG4105DQE	DNA ligase
ET495_05140	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
ET495_05145	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ET495_05150	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
ET495_05160	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
ET495_05165	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
ET495_05170	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
ET495_05175	ENOG4105CDY	transcriptional regulatory protein
ET495_05180	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
ET495_05185	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
ET495_05190	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
ET495_05205	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
ET495_05220	ENOG4105C22	threonyL-tRNA synthetase
ET495_05250	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
ET495_05265	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET495_05270	ENOG4108JGH	Tetr family transcriptional regulator
ET495_05280	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_05310	ENOG4105JSC	dimethylmenaquinone methyltransferase
ET495_05315	ENOG4105CSH	Transporter
ET495_05320	ENOG4105QPS	Monooxygenase
ET495_05325	ENOG4105C26	Dehydrogenase
ET495_05330	ENOG4105DA5	(ABC) transporter
ET495_05340	ENOG4105CJ1	ABC, transporter
ET495_05385	ENOG4105D7K	pfkb domain protein
ET495_05390	ENOG4107QKS	N-acylglucosamine 2-epimerase
ET495_05415	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_05420	ENOG4105E2R	ROK family
ET495_05450	ENOG4108MXD	gtp-binding protein
ET495_05500	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_05530	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
ET495_05535	ENOG4105C4B	ABC transporter, permease
ET495_05555	ENOG4108KD5	ADP-ribosylation crystallin J1
ET495_05590	ENOG410836F	Transposase
ET495_05595	ENOG410836F	Transposase
ET495_05600	ENOG410836F	Transposase
ET495_05605	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
ET495_05645	ENOG4105CRQ	synthase (Component I)
ET495_05685	ENOG4105CSR	polyphosphate kinase 2
ET495_05725	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
ET495_05740	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_05750	ENOG4105F1A	Pyruvate formate-lyase
ET495_05765	ENOG4105ERX	Dehydrogenase
ET495_05770	ENOG4105EEM	helicase
ET495_05770	ENOG4105EEM	helicase
ET495_05775	ENOG4105P8F	nudix hydrolase
ET495_05795	ENOG4108M15	ABC transporter
ET495_05800	ENOG4107QM5	aconitate hydratase
ET495_05820	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
ET495_05825	ENOG4105C0X	amino acid
ET495_05830	ENOG4107VEG	TrkA-N domain protein
ET495_05875	ENOG4105EN6	Membrane
ET495_05885	ENOG4107W53	thymidine kinase
ET495_05920	ENOG4108J2P	Alpha beta hydrolase fold
ET495_05940	ENOG4105CE1	Ferrous iron transport protein b
ET495_05950	ENOG4105C3R	Methionine synthase
ET495_05980	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
ET495_06010	ENOG41061P8	Persistence to inhibition of murein or DNA biosynthesis regulatory protein
ET495_06035	ENOG4105C32	Amino acid ABC transporter (Permease)
ET495_06040	ENOG4108IV0	ABC, transporter
ET495_06045	ENOG4105C0Z	ABC transporter
ET495_06085	ENOG4106UW1	Major Facilitator superfamily
ET495_06090	ENOG41080T7	secreted protein
ET495_06095	ENOG4105DBE	peroxidase
ET495_06125	ENOG410836F	Transposase
ET495_06195	ENOG4107ZVI	PhiRv2 prophage protein
ET495_06215	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
ET495_06220	ENOG4105SHT	UspA domain-containing protein
ET495_06235	ENOG4105EAH	synthase
ET495_06250	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
ET495_06270	ENOG4105DKQ	ROK family
ET495_06290	ENOG4108I0Q	anthranilate phosphoribosyltransferase
ET495_06300	ENOG4105CCU	oxidase (Subunit III)
ET495_06305	ENOG4107UDY	cytochrome C
ET495_06310	ENOG4107EUI	c reductase, iron-sulfur
ET495_06315	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
ET495_06325	ENOG4105MCD	Part of cytochrome c oxidase, its function is
ET495_06330	ENOG4105BZ9	Cytochrome C oxidase, subunit I
ET495_06335	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
ET495_06360	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
ET495_06370	ENOG4105CPC	Aldo Keto reductase
ET495_06390	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
ET495_06405	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
ET495_06435	ENOG4105D9R	oxidoreductase
ET495_06440	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
ET495_06445	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
ET495_06475	ENOG4105C5F	glutamine synthetase
ET495_06510	ENOG4105CHR	reductase
ET495_06540	ENOG4107XFJ	UPF0246 protein
ET495_06545	ENOG4105CVJ	phosphoglycerate mutase
ET495_06555	ENOG4105EGD	dinuclear metal center protein, YbgI family
ET495_06565	ENOG4105CHH	sulfate transporter
ET495_06585	ENOG4105CJ1	ABC, transporter
ET495_06595	ENOG4105C9U	ATP-dependent DNA helicase RecQ
ET495_06605	ENOG41085J0	Protein CrcB homolog
ET495_06610	ENOG41083TI	Protein CrcB homolog
ET495_06690	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
ET495_06710	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
ET495_06715	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
ET495_06730	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET495_06770	ENOG4107TXC	Transcriptional regulator
ET495_06790	ENOG4107AQZ	Membrane
ET495_06795	ENOG4108MES	Periplasmic binding protein
ET495_06800	ENOG4105DHS	permease protein
ET495_06815	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
ET495_06825	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
ET495_06830	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
ET495_06835	ENOG4105BZ4	penicillin-binding protein
ET495_06870	ENOG4107R28	alpha amylase, catalytic region
ET495_06875	ENOG4105EG2	ABC transporter, permease
ET495_06880	ENOG4105D56	permease protein
ET495_06895	ENOG4105CG3	alpha amylase, catalytic region
ET495_06930	ENOG4108Z6X	(sortase) family
ET495_06945	ENOG4105BZU	Histidine kinase
ET495_06950	ENOG4105KCT	ABC transporter
ET495_06960	ENOG4106PMH	Extracellular solute-binding protein family 3
ET495_06965	ENOG4105DRP	amino acid AbC transporter
ET495_06985	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
ET495_06990	ENOG4105DSE	periplasmic solute binding protein
ET495_06995	ENOG4105FDK	ABC transporter
ET495_07010	ENOG4105DQ5	transport system permease protein
ET495_07015	ENOG4105TVJ	transport system, permease
ET495_07020	ENOG4105E0A	ABC, transporter
ET495_07035	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ET495_07040	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
ET495_07045	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_07050	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
ET495_07055	ENOG4105WBV	Transcriptional regulator
ET495_07065	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
ET495_07085	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
ET495_07095	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
ET495_07105	ENOG4107YU2	histidine triad (hIT) protein
ET495_07115	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET495_07120	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
ET495_07125	ENOG4105XPP	Protein of unknown function (DUF1275)
ET495_07130	ENOG4105DEF	Extracellular solute-binding protein, family 5
ET495_07140	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_07150	ENOG4108JQ6	ABC transporter
ET495_07190	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
ET495_07230	ENOG4108IUK	alpha amylase, catalytic
ET495_07235	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
ET495_07255	ENOG4105EPR	degv family
ET495_07260	ENOG4105D7A	ATP-binding protein
ET495_07270	ENOG4105C26	Dehydrogenase
ET495_07315	ENOG4105C8T	Leucyl-tRNA synthetase
ET495_07325	ENOG4105F27	Major Facilitator
ET495_07345	ENOG4105FDF	Could be involved in DNA repair (By similarity)
ET495_07380	ENOG4105DWT	malate dehydrogenase (quinone)
ET495_07400	ENOG4107WA4	MmpL domain-containing protein
ET495_07410	ENOG4108NKJ	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
ET495_07415	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET495_07420	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
ET495_07425	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
ET495_07435	ENOG41080HT	Transcriptional regulator, arsr family
ET495_07445	ENOG4105CDA	abc transporter atp-binding protein
ET495_07450	ENOG4105EAB	amino acid AbC transporter
ET495_07455	ENOG4105EAD	ABC transporter
ET495_07460	ENOG4105GBT	ABC transporter
ET495_07470	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
ET495_07475	ENOG4105KTU	Transcriptional regulator, arsr family
ET495_07495	ENOG4105DIK	(ABC) transporter
ET495_07500	ENOG4105CC5	ABC transporter
ET495_07525	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
ET495_07535	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
ET495_07545	ENOG4105FDP	GntR family transcriptional regulator
ET495_07605	ENOG4105CMG	Carbohydrate kinase
ET495_07615	ENOG4105MVE	transcriptional regulator
ET495_07620	ENOG4105DYW	oxidoreductase
ET495_07625	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
ET495_07635	ENOG41069M3	Transcriptional regulator
ET495_07670	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
ET495_07675	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
ET495_07685	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET495_07725	ENOG4108Z66	YbaK ebsC protein
ET495_07735	ENOG4105DFA	alanine racemase domain protein
ET495_07740	ENOG4105DF9	Lipoate-protein, ligase
ET495_07745	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
ET495_07750	ENOG4105CM2	brancheD-chain amino acid aminotransferase
ET495_07755	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
ET495_07760	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
ET495_07765	ENOG4108ZP8	Acetolactate synthase small subunit
ET495_07775	ENOG4105KZX	Pterin carbinolamine dehydratase
ET495_07790	ENOG4105C01	Dihydroxy-acid dehydratase
ET495_07795	ENOG4105DUX	Transporter
ET495_07805	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ET495_07810	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
ET495_07815	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
ET495_07825	ENOG41069M3	Transcriptional regulator
ET495_07830	ENOG4107R9S	Malate synthase
ET495_07865	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
ET495_07870	ENOG4108EKI	Dehydrogenase
ET495_07885	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
ET495_07895	ENOG4105C10	Electron transfer flavoprotein
ET495_07915	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
ET495_07925	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
ET495_07930	ENOG4105C7N	Xanthine uracil vitamin C permease
ET495_07935	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
ET495_07960	ENOG4107S9D	Alpha beta hydrolase
ET495_07975	ENOG4108V1T	peptidylprolyl cis-trans isomerase
ET495_07995	ENOG41076CZ	activating enzyme
ET495_08015	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ET495_08080	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_08110	ENOG4105F9F	transposase
ET495_08150	ENOG4105BZU	Histidine kinase
ET495_08155	ENOG4105ETX	regulatoR
ET495_08160	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
ET495_08165	ENOG4105C4B	ABC transporter, permease
ET495_08205	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_08240	ENOG4105DR5	peptidase
ET495_08335	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_08395	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
ET495_08405	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
ET495_08420	ENOG4105CE4	GlcNAc 6-P deacetylase
ET495_08425	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
ET495_08435	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
ET495_08440	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
ET495_08445	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
ET495_08450	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
ET495_08455	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
ET495_08460	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
ET495_08470	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
ET495_08490	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
ET495_08495	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
ET495_08500	ENOG4105VFB	Binds the 23S rRNA (By similarity)
ET495_08515	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
ET495_08520	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
ET495_08525	ENOG4105D6E	homoserine dehydrogenase
ET495_08530	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
ET495_08535	ENOG4105C75	arginyL-tRNA synthetase
ET495_08560	ENOG4105CR4	methylisocitrate lyase
ET495_08595	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_08600	ENOG4105EB3	Histidine kinase
ET495_08605	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
ET495_08610	ENOG4107SET	aldo keto reductase
ET495_08640	ENOG4105EMN	RNA polymerase sigma factor
ET495_08650	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
ET495_08655	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
ET495_08660	ENOG4107TK4	histidinol-phosphate phosphatase
ET495_08670	ENOG4105C6K	Malic enzyme
ET495_08680	ENOG4107RWI	ethanolamine utilization protein eutJ
ET495_08690	ENOG4105NDK	ethanolamine utilization protein
ET495_08695	ENOG4105KNY	Microcompartments protein
ET495_08700	ENOG4108EKI	Dehydrogenase
ET495_08705	ENOG4106D67	ethanolamine utilization protein
ET495_08710	ENOG4107FQ9	ethanolamine ammonia-lyase
ET495_08715	ENOG4105CPD	ethanolamine ammonia-lyase
ET495_08720	ENOG4105DYY	Reactivating factor for ethanolamine ammonia lyase
ET495_08725	ENOG4105WVM	ethanolamine utilization protein EutN carboxysome structural protein Ccml
ET495_08730	ENOG4105ENY	Ethanolamine utilization protein eutH
ET495_08740	ENOG4108JJB	ABC transporter
ET495_08760	ENOG4105CT4	transporter
ET495_08795	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
ET495_08800	ENOG4105T0Z	Conserved Protein
ET495_08805	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
ET495_08810	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
ET495_08820	ENOG4105BZU	Histidine kinase
ET495_08825	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_08835	ENOG4108WQ6	secreted protein
ET495_08840	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
ET495_08875	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
ET495_08885	ENOG4105D3Q	Sugar transferase
ET495_08890	ENOG4105D3Q	Sugar transferase
ET495_08915	ENOG4105JNK	Glycosyl transferase (Group 1
ET495_08925	ENOG4107YJ4	chain length determinant protein
ET495_08950	ENOG4107QKV	phosphomannomutase
ET495_08955	ENOG4105EIP	mannose-6-phosphate isomerase
ET495_08995	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET495_09035	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
ET495_09040	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
ET495_09045	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
ET495_09050	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
ET495_09085	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
ET495_09115	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
ET495_09120	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
ET495_09130	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ET495_09170	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
ET495_09205	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
ET495_09235	ENOG4108TJN	glycosyl transferase group 1
ET495_09240	ENOG4105MFV	ABC-2 type transporter
ET495_09245	ENOG4105EY8	ABC transporter
ET495_09265	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ET495_09270	ENOG4108KGH	TRANSCRIPTIONal
ET495_09280	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
ET495_09295	ENOG41065SU	Two-component system sensor kinase
ET495_09300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_09305	ENOG4105BZU	Histidine kinase
ET495_09310	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_09315	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_09325	ENOG4105EC2	ftsk spoIIIe
ET495_09360	ENOG4105I1K	ABC transporter
ET495_09370	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_09375	ENOG4105E2V	Glycosyltransferase 36
ET495_09380	ENOG4105CUB	amino acid
ET495_09385	ENOG4105C26	Dehydrogenase
ET495_09395	ENOG4105D82	Glutamate dehydrogenase
ET495_09400	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
ET495_09405	ENOG4107JTW	chlorite dismutase
ET495_09410	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
ET495_09425	ENOG4105BZW	Glycerate kinase
ET495_09435	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
ET495_09445	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
ET495_09455	ENOG4105C9Q	fumarate hydratase class II
ET495_09470	ENOG4105C3U	ABC transporter
ET495_09490	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
ET495_09495	ENOG4108IAB	Phoh family
ET495_09505	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
ET495_09520	ENOG4107R9S	Malate synthase
ET495_09530	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_09535	ENOG4105ENE	Histidine kinase
ET495_09545	ENOG4105CSU	acyl-Coa dehydrogenase
ET495_09590	ENOG4105DHU	Bile acid
ET495_09595	ENOG4105D7K	pfkb domain protein
ET495_09600	ENOG4108UHU	Aldolase
ET495_09610	ENOG41068KF	Universal stress protein
ET495_09625	ENOG4105NAE	bifunctional deaminase-reductase domain protein
ET495_09635	ENOG41073R8	VanW family
ET495_09660	ENOG4107YCY	Transcriptional regulator
ET495_09670	ENOG4105CNN	ABC, transporter
ET495_09690	ENOG4105DIA	mandelate racemase muconate lactonizing
ET495_09695	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET495_09705	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
ET495_09715	ENOG41080R8	Conserved Protein
ET495_09740	ENOG4108638	50S ribosomal protein L36
ET495_09790	ENOG4105BZU	Histidine kinase
ET495_09795	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_09810	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_09985	ENOG4107SID	ATP-dependent exodnase (exonuclease v)
ET495_10085	ENOG4105E4C	Lytic transglycosylase catalytic
ET495_10235	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
ET495_10250	ENOG4107SFI	Major Facilitator superfamily
ET495_10255	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_10285	ENOG4105C93	Xylose Isomerase
ET495_10335	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
ET495_10365	ENOG4105XT2	Transcriptional regulator
ET495_10430	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
ET495_10435	ENOG4107SFI	Major Facilitator superfamily
ET495_10440	ENOG4105XMC	MarR family Transcriptional regulator
ET495_10455	ENOG4105C5Y	PTS System
ET495_10460	ENOG4105CI1	PTS System
ET495_10465	ENOG4105CI1	PTS System
ET495_10470	ENOG4105FDP	GntR family transcriptional regulator
ET495_10480	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
ET495_10485	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
ET495_10490	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
ET495_10510	ENOG4108KGH	TRANSCRIPTIONal
ET495_10525	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET495_10575	ENOG4105C7N	Xanthine uracil vitamin C permease
ET495_10580	ENOG4105D3Q	Sugar transferase
ET495_10615	ENOG4105VEQ	Cold shock protein
ET495_10625	ENOG4105CFI	type iii restriction protein res subunit
ET495_10650	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_10655	ENOG4105BZU	Histidine kinase
ET495_10670	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
ET495_10690	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
ET495_10710	ENOG4108762	serine threonine protein kinase
ET495_10715	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
ET495_10735	ENOG4105C8N	cysteinyl-tRNA synthetase
ET495_10755	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
ET495_10760	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
ET495_10775	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ET495_10790	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
ET495_10795	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
ET495_10800	ENOG4105E2Z	phosphate ABC transporter (Permease
ET495_10810	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
ET495_10815	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
ET495_10820	ENOG4105BZU	Histidine kinase
ET495_10825	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
ET495_10830	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
ET495_10845	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
ET495_10865	ENOG4105CRK	lysyL-tRNA synthetase
ET495_10895	ENOG4105EEI	dihydropteroate synthase
ET495_10900	ENOG4105EUJ	GTP cyclohydrolase i
ET495_10905	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
ET495_10915	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
ET495_10925	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
ET495_10930	ENOG4105F0N	pyrophosphate phospho-hydrolase
ET495_10945	ENOG4108FKR	NLP P60 protein
ET495_10955	ENOG4105DWV	Homoserine O-trans-acetylase
ET495_10985	ENOG4105EIH	LPPG Fo 2-phospho-L-lactate transferase
ET495_11000	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
ET495_11005	ENOG4105CQB	FAD linked oxidase domain protein
ET495_11010	ENOG4108Z9K	Osmotically inducible protein
ET495_11035	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
ET495_11070	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
ET495_11085	ENOG4108YYC	ycei family
ET495_11095	ENOG4107NHD	transcriptional regulator
ET495_11100	ENOG4105D74	hydrolase
ET495_11125	ENOG4105BZ4	penicillin-binding protein
ET495_11130	ENOG4105DIN	metallophosphoesterase
ET495_11175	ENOG4105CPQ	Dehydrogenase
ET495_11200	ENOG4105C0Z	ABC transporter
ET495_11205	ENOG4108IV0	ABC, transporter
ET495_11230	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
ET495_11275	ENOG4107ZVI	PhiRv2 prophage protein
ET495_11300	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
ET495_11315	ENOG4105CMR	udp-glucose 4-epimerase
ET495_11325	ENOG4105C85	amino acid
ET495_11380	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
ET495_11395	ENOG4105CGH	5'-nucleotidase
ET495_11410	ENOG4105TMB	Formate nitrite transporter
ET495_11420	ENOG4105MXW	flavin reductase domain protein, FMN-binding
ET495_11430	ENOG4105CPU	Monooxygenase
ET495_11450	ENOG4108Z0R	Transferase
ET495_11455	ENOG4105FBW	Monooxygenase
ET495_11465	ENOG4105DEN	Luciferase family
ET495_11470	ENOG4105EAB	amino acid AbC transporter
ET495_11495	ENOG4108JQ6	ABC transporter
ET495_11500	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_11510	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
ET495_11520	ENOG4105E9K	Isocitrate dehydrogenase
ET495_11550	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
ET495_11570	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_11575	ENOG4105CHR	reductase
ET495_11635	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_11705	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
ET495_11710	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
ET495_11715	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
ET495_11725	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
ET495_11760	ENOG4105C8V	SAICAR synthetase
ET495_11765	ENOG4105C12	Phosphoribosylglycinamide synthetase
ET495_11775	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
ET495_11840	ENOG4105DQR	SNARE associated Golgi
ET495_11850	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
ET495_11860	ENOG4107FW0	short-chain dehydrogenase reductase
ET495_11885	ENOG4108MRH	transcriptional regulatory protein
ET495_11895	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
ET495_11905	ENOG4105DEF	Extracellular solute-binding protein, family 5
ET495_11935	ENOG4105CPQ	Dehydrogenase
ET495_11940	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
ET495_11945	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ET495_11965	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
ET495_11985	ENOG4108JPZ	Monovalent cation H antiporter subunit D
ET495_11990	ENOG4105MKQ	Monovalent cation H antiporter subunit C
ET495_11995	ENOG4105D65	subunit l
ET495_12005	ENOG4105DHP	deoxycytidine triphosphate deaminase
ET495_12015	ENOG4105EUB	pirin domain protein
ET495_12040	ENOG4108KQI	regulatory protein luxr
ET495_12055	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
ET495_12060	ENOG4105C5Y	PTS System
ET495_12070	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
ET495_12075	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
ET495_12090	ENOG4105CV8	reductase
ET495_12110	ENOG4105EYF	MMPL domain protein
ET495_12125	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
ET495_12130	ENOG4105CPP	Dehydrogenase, E1 component
ET495_12140	ENOG4105CIH	Imidazole acetol-phosphate transaminase
ET495_12145	ENOG41082T9	Membrane
ET495_12160	ENOG4107QTF	adenylosuccinate lyase
ET495_12170	ENOG4105CID	antiterminator
ET495_12195	ENOG4105MP0	transposase
ET495_12225	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
ET495_12230	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
ET495_12235	ENOG4105EPJ	extracellular solute-binding protein family 1
ET495_12255	ENOG4108KP7	hydrolase
ET495_12260	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
ET495_12315	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
ET495_12320	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
ET495_12325	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
ET495_12345	ENOG4105D52	delta-aminolevulinic acid dehydratase
ET495_12350	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
ET495_12355	ENOG4105VPX	protein, conserved in bacteria
ET495_12385	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET495_12400	ENOG4108426	dNA-binding protein
ET495_12430	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_12450	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
ET495_12485	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
ET495_12515	ENOG4105D22	carbon starvation protein
ET495_12535	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
ET495_12585	ENOG4105CIK	Amidinotransferase
ET495_12600	ENOG41080V3	Major Facilitator superfamily
ET495_12620	ENOG4108AZI	Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity)
ET495_12630	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
ET495_12645	ENOG4105CJW	magnesium transporter
ET495_12650	ENOG4105C7K	acetolactate synthase
ET495_12745	ENOG4108W5M	transcriptional regulator
ET495_12750	ENOG4105CHR	reductase
ET495_12760	ENOG4108SC4	)-transporter
ET495_12780	ENOG4105CDU	Replicative dna helicase
ET495_12785	ENOG4105UQX	Mate efflux family protein
ET495_12790	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
ET495_12795	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
ET495_12805	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
ET495_12815	ENOG4105K7K	Transcriptional regulator
ET495_12820	ENOG4105CZA	synthase
ET495_12920	ENOG41062IR	nudix hydrolase
ET495_12945	ENOG4105C3M	thioredoxin reductase
ET495_12950	ENOG4105K63	Thioredoxin
ET495_12960	ENOG4105CPF	Cell wall formation (By similarity)
ET495_12970	ENOG4107QJE	Chromosome Partitioning Protein
ET495_12975	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
ET495_12990	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
ET495_12995	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
ET495_13000	ENOG41084CH	50S ribosomal protein l34
ET495_13005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
ET495_13010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
ET495_13015	ENOG4108J5G	6-phosphogluconate dehydrogenase
ET495_13025	ENOG4105K7N	UPF0232 protein
ET495_13030	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET495_13035	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
ET495_13055	ENOG4105EB3	Histidine kinase
ET495_13060	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
ET495_13075	ENOG4105CSR	polyphosphate kinase 2
ET495_13095	ENOG4105ZJT	Cell division protein CrgA
ET495_13105	ENOG4108U4N	(sortase) family
ET495_13115	ENOG4105D9P	serine threonine protein kinase
ET495_13120	ENOG4107TPY	serine threonine protein kinase
ET495_13140	ENOG4105HZM	Fha domain containing protein
ET495_13170	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_13195	ENOG4105KJF	protein tyrosine phosphatase
ET495_13220	ENOG4105CHM	Aminotransferase
ET495_13255	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
ET495_13260	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
ET495_13290	ENOG4105SYT	Methylenetetrahydrofolate reductase
ET495_13300	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_13315	ENOG4108R3E	Dna-3-methyladenine glycosylase i
ET495_13340	ENOG4108ZG0	Ompa motb domain protein
ET495_13345	ENOG4105CK2	sodium dicarboxylate symporter
ET495_13350	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
ET495_13355	ENOG4108MRH	transcriptional regulatory protein
ET495_13360	ENOG4108UVJ	appr-1-p processing domain protein
ET495_13380	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
ET495_13410	ENOG4105E5Q	amino acid AbC transporter
ET495_13435	ENOG4105VEQ	Cold shock protein
ET495_13445	ENOG4108IV0	ABC, transporter
ET495_13450	ENOG4105C0Z	ABC transporter
ET495_13455	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
ET495_13460	ENOG4105C32	Amino acid ABC transporter (Permease)
ET495_13480	ENOG4105C5W	Aldolase
ET495_13505	ENOG4105K5B	UPF0225 protein
ET495_13510	ENOG4105F27	Major Facilitator
ET495_13580	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
ET495_13590	ENOG4108X07	Tetr family transcriptional regulator
ET495_13595	ENOG4105CIG	ABC transporter
ET495_13630	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
ET495_13635	ENOG4108IXY	short-chain dehydrogenase reductase
ET495_13645	ENOG4108ZM9	phosphoglycerate mutase
ET495_13665	ENOG4105C6Z	Gluconate
ET495_13670	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
ET495_13740	ENOG41060M0	Crispr-associated protein, cse4 family
ET495_13745	ENOG4108VWQ	crispr-associated protein
ET495_13790	ENOG4108VC7	Protein of unknown function (DUF2587)
ET495_13795	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
ET495_13805	ENOG4105GWZ	Roadblock lc7 family protein
ET495_13875	ENOG4107QP8	phosphohexose isomerase
ET495_13880	ENOG4106N3A	copper homeostasis protein cutc
ET495_13885	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_13895	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
ET495_13905	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
ET495_13955	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
ET495_13960	ENOG4107RSS	Hydrogenase accessory protein HypB
ET495_13975	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
ET495_13980	ENOG4108USZ	hydrogenase
ET495_13985	ENOG4105X7T	Ni Fe-hydrogenase, b-type cytochrome subunit
ET495_13990	ENOG4105DPX	Hydrogenase, large subunit
ET495_13995	ENOG4105E3S	small subunit
ET495_14000	ENOG4108UHE	carbonic anhydrase
ET495_14010	ENOG4105CQS	hydrogenase expression formation protein HypD
ET495_14040	ENOG4105CHR	reductase
ET495_14065	ENOG4105CFG	Acts as a chaperone (By similarity)
ET495_14075	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
ET495_14080	ENOG4105KNI	merR family transcriptional Regulator
ET495_14095	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
ET495_14100	ENOG4108Z6B	deaminase
ET495_14110	ENOG4105BZ1	(ABC) transporter
ET495_14150	ENOG4106H3A	restriction
ET495_14215	ENOG4105I1K	ABC transporter
ET495_14220	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
ET495_14235	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_14245	ENOG4108MJN	Glycosyl Transferase
ET495_14265	ENOG4105C1G	acyl-Coa dehydrogenase
ET495_14285	ENOG4105MC2	DSBA oxidoreductase
ET495_14295	ENOG4105C2W	permease
ET495_14325	ENOG4105CHR	reductase
ET495_14355	ENOG4105D01	(LipO)protein
ET495_14360	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ET495_14365	ENOG4108UMI	ABC transporter, permease
ET495_14375	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
ET495_14390	ENOG4105CNN	ABC, transporter
ET495_14395	ENOG4105DFW	ABC transporter
ET495_14410	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_14425	ENOG4105DRS	transport system, permease
ET495_14440	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
ET495_14455	ENOG4105D7N	magnesium and cobalt transport protein CorA
ET495_14460	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
ET495_14485	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
ET495_14540	ENOG4105C1J	atp-dependent rna helicase
ET495_14550	ENOG4105E0X	reductase
ET495_14565	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
ET495_14590	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
ET495_14605	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ET495_14610	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
ET495_14660	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
ET495_14675	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ET495_14705	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
ET495_14715	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_14725	ENOG4107QI6	Cysteine desulfurase
ET495_14730	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
ET495_14735	ENOG4108IYU	L-aspartate oxidase
ET495_14740	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
ET495_14760	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
ET495_14790	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET495_14800	ENOG4108YV4	Universal stress protein
ET495_14810	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
ET495_14825	ENOG4105DRS	transport system, permease
ET495_14860	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
ET495_14875	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_14910	ENOG41073TP	transcriptional regulator
ET495_14920	ENOG4105CPC	Aldo Keto reductase
ET495_14925	ENOG4108RVA	ribokinase
ET495_14935	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
ET495_14940	ENOG4105CKW	Inner membrane protein yedI
ET495_14945	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
ET495_14980	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
ET495_14985	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
ET495_15005	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
ET495_15010	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
ET495_15025	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_15040	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
ET495_15080	ENOG4105C0D	helicase
ET495_15085	ENOG4107ZYR	domain protein
ET495_15090	ENOG4105CZN	Potassium uptake protein
ET495_15095	ENOG4105DGU	Histone deacetylase
ET495_15105	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
ET495_15115	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
ET495_15130	ENOG4108RH7	phosphoglycerate mutase
ET495_15140	ENOG4107QIV	Cytochrome c biogenesis protein
ET495_15150	ENOG4105CRE	cytochrome C
ET495_15175	ENOG4108R5T	secreted protein
ET495_15210	ENOG4107SIQ	Naphthoate synthase
ET495_15215	ENOG4107TCW	O-succinylbenzoate synthase
ET495_15220	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
ET495_15245	ENOG4107QJQ	Mate efflux family protein
ET495_15250	ENOG4105C0D	helicase
ET495_15265	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ET495_15270	ENOG4105E4F	Isochorismate synthase
ET495_15275	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
ET495_15285	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_15295	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ET495_15300	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_15315	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_15325	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_15340	ENOG4108IEH	NADH dehydrogenase subunit g
ET495_15350	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_15355	ENOG41087XN	oxidoreductase
ET495_15360	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_15365	ENOG4105D65	subunit l
ET495_15375	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
ET495_15390	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_15405	ENOG4108ZF3	Phosphatase
ET495_15445	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_15490	ENOG4105BZU	Histidine kinase
ET495_15495	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_15510	ENOG4105F37	PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6
ET495_15540	ENOG4105D0M	Protease HtpX homolog
ET495_15555	ENOG410667J	hydrolase
ET495_15560	ENOG4108VPT	UPF0234 protein
ET495_15580	ENOG4105WDJ	50S ribosomal protein L33
ET495_15585	ENOG410900P	UPF0336 protein
ET495_15600	ENOG4106UW1	Major Facilitator superfamily
ET495_15605	ENOG4107R4N	Cell wall formation (By similarity)
ET495_15615	ENOG4105KME	endoribonuclease L-psp
ET495_15620	ENOG4105ERH	Fumarylacetoacetate hydrolase
ET495_15625	ENOG4105C29	acyl-CoA thioesterase
ET495_15660	ENOG4106IPI	cyclase, family
ET495_15690	ENOG4105BZU	Histidine kinase
ET495_15725	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
ET495_15730	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
ET495_15750	ENOG4108VZM	50s ribosomal protein L10
ET495_15755	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
ET495_15760	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET495_15770	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
ET495_15775	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
ET495_15780	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
ET495_15785	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
ET495_15790	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
ET495_15795	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
ET495_15800	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
ET495_15805	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
ET495_15810	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ET495_15815	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
ET495_15820	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
ET495_15825	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
ET495_15830	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
ET495_15835	ENOG41082SA	50s ribosomal protein l29
ET495_15840	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
ET495_15845	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
ET495_15850	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
ET495_15855	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ET495_15860	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
ET495_15865	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
ET495_15870	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
ET495_15880	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
ET495_15885	ENOG410849U	50S ribosomal protein L30
ET495_15890	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
ET495_15895	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
ET495_15900	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
ET495_15910	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
ET495_15915	ENOG41067V7	50S ribosomal protein L36
ET495_15920	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ET495_15925	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
ET495_15930	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
ET495_15935	ENOG4108ZT0	50S ribosomal protein l17
ET495_15945	ENOG4105DFK	Polyphosphate glucokinase
ET495_15950	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
ET495_15965	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
ET495_15970	ENOG4108UJD	30S ribosomal protein S9
ET495_15980	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
ET495_15995	ENOG4105CS9	pantothenic acid kinase
ET495_16000	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
ET495_16005	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
ET495_16010	ENOG4105EQP	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity)
ET495_16035	ENOG4108V06	Glutathione peroxidase
ET495_16040	ENOG4108YBP	pseudouridine synthase
ET495_16055	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
ET495_16060	ENOG4108097	ATP-binding protein
ET495_16070	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
ET495_16080	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
ET495_16085	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
ET495_16105	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
ET495_16110	ENOG4105KIU	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET495_16120	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
ET495_16130	ENOG4107QVP	Dehydrogenase
ET495_16135	ENOG4105C26	Dehydrogenase
ET495_16150	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
ET495_16160	ENOG4107QRI	Phosphoketolase
ET495_16170	ENOG4105BZ1	(ABC) transporter
ET495_16175	ENOG4105BZ1	(ABC) transporter
ET495_16180	ENOG4105WX6	Membrane
ET495_16185	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
ET495_16210	ENOG4105WH1	Two component transcriptional regulator luxr family
ET495_16275	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
ET495_16280	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
ET495_16285	ENOG4105FBW	Monooxygenase
ET495_16295	ENOG4105K4P	CoA-binding domain protein
ET495_16305	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_16310	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
ET495_16350	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
ET495_16390	ENOG4105DKQ	ROK family
ET495_16395	ENOG4105DFW	ABC transporter
ET495_16405	ENOG4107RNG	ABC transporter
ET495_16415	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
ET495_16420	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
ET495_16435	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ET495_16450	ENOG4105F44	Two component transcriptional regulator, winged helix family
ET495_16455	ENOG4106F60	Histidine kinase
ET495_16470	ENOG4105CJW	magnesium transporter
ET495_16480	ENOG4107T6F	Xaa-Pro aminopeptidase
ET495_16500	ENOG4108YZG	isomerase
ET495_16510	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
ET495_16535	ENOG4105C10	Electron transfer flavoprotein
ET495_16540	ENOG4105CEY	Amp-dependent synthetase and ligase
ET495_16580	ENOG4105C1J	atp-dependent rna helicase
ET495_16610	ENOG4105E09	nadh pyrophosphatase
ET495_16630	ENOG4105WBQ	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
ET495_16655	ENOG4105DJZ	UPF0182 protein
ET495_16675	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
ET495_16680	ENOG4107HQ7	repeat protein
ET495_16685	ENOG4105EZV	Transcriptional regulator
ET495_16690	ENOG4105ETE	Transcriptional regulator (LacI family
ET495_16720	ENOG4105DET	Rhamnulokinase
ET495_16735	ENOG4105CT8	Phosphorylase
ET495_16740	ENOG4105C0A	alcohol dehydrogenase
ET495_16815	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
ET495_16820	ENOG4108UMI	ABC transporter, permease
ET495_16825	ENOG4105D01	(LipO)protein
ET495_16855	ENOG4105CHR	reductase
ET495_16860	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
ET495_16870	ENOG4108JP0	extracellular solute-binding protein family 1
ET495_16880	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
ET495_16920	ENOG4105VFR	signal peptidase
ET495_16935	ENOG4105CHU	acetyl-coa acetyltransferase
ET495_16945	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
ET495_16950	ENOG4108TZA	Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity)
ET495_16955	ENOG4105DXM	phenylacetic acid degradation protein
ET495_16970	ENOG4108ZJI	phenylacetic acid degradation protein
ET495_16975	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
ET495_16980	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
ET495_16985	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
ET495_16990	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
ET495_16995	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
ET495_17035	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
ET495_17080	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
ET495_17115	ENOG4105E2D	ec 3.2.1.52
ET495_17130	ENOG4108RWI	nicotinamidase
ET495_17145	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
ET495_17150	ENOG4105F8V	Hydrolase, tatD family
ET495_17175	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
ET495_17180	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
ET495_17185	ENOG4105I82	acetyl xylan esterase
ET495_17190	ENOG4105C5H	ABC transporter
ET495_17195	ENOG4105M4B	Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity)
ET495_17240	ENOG4105DJ2	Major Facilitator Superfamily
ET495_17245	ENOG4105FS7	Transcriptional regulator
ET495_17290	ENOG4105E4C	Lytic transglycosylase catalytic
ET495_17295	ENOG4107SN7	NLP P60 protein
ET495_17365	ENOG4105FA0	parb-like partition protein
ET495_17410	ENOG4105MZU	cell filamentation protein
ET495_17415	ENOG4108C33	Resolvase