locus-tag	class	description
Xcel_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Xcel_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Xcel_0003	ENOG4108J5G	6-phosphogluconate dehydrogenase
Xcel_0004	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Xcel_0005	ENOG4105K7N	UPF0232 protein
Xcel_0006	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Xcel_0007	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Xcel_0013	ENOG4105ZJT	Cell division protein CrgA
Xcel_0015	ENOG4108U4N	(sortase) family
Xcel_0018	ENOG4105D9P	serine threonine protein kinase
Xcel_0019	ENOG4107TPY	serine threonine protein kinase
Xcel_0020	ENOG4105CJN	penicillin-binding protein
Xcel_0023	ENOG4105HZM	Fha domain containing protein
Xcel_0028	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_0033	ENOG4105ECR	NmrA family
Xcel_0034	ENOG4105KJF	protein tyrosine phosphatase
Xcel_0039	ENOG4105CHM	Aminotransferase
Xcel_0043	ENOG4105EXG	Transcriptional regulator
Xcel_0044	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcel_0045	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Xcel_0046	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Xcel_0051	ENOG4105SYT	Methylenetetrahydrofolate reductase
Xcel_0053	ENOG4105CEY	Amp-dependent synthetase and ligase
Xcel_0055	ENOG4108R3E	Dna-3-methyladenine glycosylase i
Xcel_0062	ENOG4105CG3	alpha amylase, catalytic region
Xcel_0065	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
Xcel_0066	ENOG4107RSM	transcriptional regulator
Xcel_0069	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Xcel_0071	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Xcel_0073	ENOG4108UVJ	appr-1-p processing domain protein
Xcel_0074	ENOG4105CQ7	ATP-dependent helicase
Xcel_0077	ENOG4105ENE	Histidine kinase
Xcel_0078	ENOG4105D2N	Aldolase
Xcel_0079	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
Xcel_0081	ENOG4105CMT	Dihydroxyacetone kinase
Xcel_0094	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0096	ENOG4105CJ1	ABC, transporter
Xcel_0100	ENOG4105E5Q	amino acid AbC transporter
Xcel_0101	ENOG4105CDA	abc transporter atp-binding protein
Xcel_0103	ENOG4105VEQ	Cold shock protein
Xcel_0105	ENOG4108IV0	ABC, transporter
Xcel_0106	ENOG4105C0Z	ABC transporter
Xcel_0107	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Xcel_0108	ENOG4105C32	Amino acid ABC transporter (Permease)
Xcel_0109	ENOG4105CUG	Oligopeptidase b
Xcel_0113	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0131	ENOG41061CK	Antibiotic biosynthesis monooxygenase
Xcel_0133	ENOG41090KN	UPF0303 protein
Xcel_0134	ENOG4107TXC	Transcriptional regulator
Xcel_0138	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Xcel_0142	ENOG4105CHH	sulfate transporter
Xcel_0144	ENOG4108X07	Tetr family transcriptional regulator
Xcel_0145	ENOG4105CIG	ABC transporter
Xcel_0152	ENOG4105M0J	Toxic component of a toxin-antitoxin (TA) module. A
Xcel_0155	ENOG4108ZM9	phosphoglycerate mutase
Xcel_0160	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Xcel_0162	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
Xcel_0166	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Xcel_0169	ENOG4108VC7	Protein of unknown function (DUF2587)
Xcel_0170	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Xcel_0172	ENOG4105GWZ	Roadblock lc7 family protein
Xcel_0179	ENOG4105F38	ABC transporter, permease
Xcel_0180	ENOG4108UCS	ABC, transporter
Xcel_0183	ENOG4107QP8	phosphohexose isomerase
Xcel_0186	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0187	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
Xcel_0192	ENOG4108YV4	Universal stress protein
Xcel_0194	ENOG4105D9U	N-acetyltransferase
Xcel_0201	ENOG4105CFG	Acts as a chaperone (By similarity)
Xcel_0203	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Xcel_0204	ENOG4105KNI	merR family transcriptional Regulator
Xcel_0207	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Xcel_0208	ENOG4108Z6B	deaminase
Xcel_0210	ENOG4105BZ1	(ABC) transporter
Xcel_0212	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0223	ENOG4105C1G	acyl-Coa dehydrogenase
Xcel_0226	ENOG4106UW1	Major Facilitator superfamily
Xcel_0229	ENOG4105MC2	DSBA oxidoreductase
Xcel_0233	ENOG4105C2W	permease
Xcel_0239	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0240	ENOG4105BZU	Histidine kinase
Xcel_0244	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0249	ENOG4105D01	(LipO)protein
Xcel_0250	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Xcel_0251	ENOG4108UMI	ABC transporter, permease
Xcel_0256	ENOG4105DAG	ROK family
Xcel_0258	ENOG4105CNN	ABC, transporter
Xcel_0259	ENOG4105DFW	ABC transporter
Xcel_0263	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Xcel_0266	ENOG4108JQ6	ABC transporter
Xcel_0269	ENOG4107QKS	N-acylglucosamine 2-epimerase
Xcel_0271	ENOG4105D7N	magnesium and cobalt transport protein CorA
Xcel_0272	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Xcel_0281	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
Xcel_0282	ENOG4105CFH	Aspartokinase
Xcel_0285	ENOG4105C0D	helicase
Xcel_0287	ENOG4105KVH	Transcriptional regulator
Xcel_0292	ENOG4105C1J	atp-dependent rna helicase
Xcel_0293	ENOG4105E0X	reductase
Xcel_0300	ENOG4105CJ3	phosphate transporter
Xcel_0302	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Xcel_0304	ENOG4105KME	endoribonuclease L-psp
Xcel_0305	ENOG4105ERH	Fumarylacetoacetate hydrolase
Xcel_0306	ENOG4105C29	acyl-CoA thioesterase
Xcel_0310	ENOG4105CPU	Monooxygenase
Xcel_0313	ENOG4106IPI	cyclase, family
Xcel_0316	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
Xcel_0317	ENOG4105DFS	Conserved Protein
Xcel_0318	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Xcel_0319	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Xcel_0330	ENOG4108I5C	dEAD DEAH box helicase
Xcel_0333	ENOG4105DFM	M18 family aminopeptidase
Xcel_0336	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Xcel_0337	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
Xcel_0342	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Xcel_0344	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Xcel_0345	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_0346	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_0347	ENOG4107QI6	Cysteine desulfurase
Xcel_0348	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Xcel_0349	ENOG4108IYU	L-aspartate oxidase
Xcel_0350	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Xcel_0354	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Xcel_0358	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Xcel_0363	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Xcel_0364	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Xcel_0366	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0368	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Xcel_0372	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0375	ENOG41073TP	transcriptional regulator
Xcel_0377	ENOG4105CPC	Aldo Keto reductase
Xcel_0380	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_0383	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Xcel_0384	ENOG4105CKW	Inner membrane protein yedI
Xcel_0386	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
Xcel_0389	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
Xcel_0390	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Xcel_0391	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
Xcel_0396	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
Xcel_0399	ENOG4105II7	pyrroline-5-carboxylate reductase
Xcel_0400	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0402	ENOG4105CR5	Class II aldolase adducin family protein
Xcel_0403	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
Xcel_0404	ENOG4105DFW	ABC transporter
Xcel_0406	ENOG4108HWW	ABC transporter
Xcel_0408	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0410	ENOG4105DRS	transport system, permease
Xcel_0411	ENOG4108JE9	extracellular solute-binding protein family 1
Xcel_0414	ENOG4105CZV	ABC transporter
Xcel_0419	ENOG4107R5U	Periplasmic binding protein LacI transcriptional regulator
Xcel_0420	ENOG4105C2J	ABC transporter
Xcel_0421	ENOG4107R9N	ABC transporter
Xcel_0422	ENOG41062B0	ABC transporter, permease
Xcel_0423	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Xcel_0424	ENOG4105E2Y	ABC, transporter
Xcel_0426	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
Xcel_0427	ENOG4105CYP	glycoside hydrolase, family
Xcel_0428	ENOG4107ZYR	domain protein
Xcel_0429	ENOG4105CZN	Potassium uptake protein
Xcel_0430	ENOG4105DGU	Histone deacetylase
Xcel_0431	ENOG4105D4R	Catalyzes the desulfonation of aliphatic sulfonates (By similarity)
Xcel_0432	ENOG4105CPC	Aldo Keto reductase
Xcel_0433	ENOG4105CPU	Monooxygenase
Xcel_0434	ENOG4105E2Y	ABC, transporter
Xcel_0435	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Xcel_0438	ENOG4108RXW	HAD-superfamily subfamily IB hydrolase
Xcel_0440	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
Xcel_0443	ENOG4108RH7	phosphoglycerate mutase
Xcel_0445	ENOG4107QIV	Cytochrome c biogenesis protein
Xcel_0446	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
Xcel_0447	ENOG4105CRE	cytochrome C
Xcel_0452	ENOG4108R5T	secreted protein
Xcel_0455	ENOG4107SIQ	Naphthoate synthase
Xcel_0457	ENOG4107TCW	O-succinylbenzoate synthase
Xcel_0458	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
Xcel_0460	ENOG4108RZE	Tetr family transcriptional regulator
Xcel_0465	ENOG4107QJQ	Mate efflux family protein
Xcel_0466	ENOG4105E4F	Isochorismate synthase
Xcel_0467	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Xcel_0468	ENOG4105P52	geranylgeranyl reductase
Xcel_0470	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Xcel_0471	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Xcel_0472	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Xcel_0474	ENOG4107QIZ	NADH dehydrogenase
Xcel_0475	ENOG4108IEH	NADH dehydrogenase subunit g
Xcel_0476	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Xcel_0477	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Xcel_0478	ENOG41087XN	oxidoreductase
Xcel_0479	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Xcel_0480	ENOG4105D65	subunit l
Xcel_0482	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Xcel_0485	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Xcel_0493	ENOG4105EC2	ftsk spoIIIe
Xcel_0503	ENOG4105D0M	Protease HtpX homolog
Xcel_0505	ENOG410667J	hydrolase
Xcel_0506	ENOG4105I1F	Resistance protein
Xcel_0508	ENOG4108VPT	UPF0234 protein
Xcel_0524	ENOG4105WXW	Antirepressor
Xcel_0566	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Xcel_0577	ENOG4105CDU	Replicative dna helicase
Xcel_0598	ENOG4105WDJ	50S ribosomal protein L33
Xcel_0599	ENOG410900P	UPF0336 protein
Xcel_0602	ENOG4106UW1	Major Facilitator superfamily
Xcel_0603	ENOG4107R4N	Cell wall formation (By similarity)
Xcel_0606	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0607	ENOG4105BZU	Histidine kinase
Xcel_0608	ENOG4107QWP	ABC-2 type transporter
Xcel_0610	ENOG410683Z	Preprotein translocase SecE subunit
Xcel_0612	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Xcel_0613	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Xcel_0618	ENOG4108VZM	50s ribosomal protein L10
Xcel_0619	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Xcel_0620	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Xcel_0621	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Xcel_0622	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Xcel_0623	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Xcel_0624	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Xcel_0625	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Xcel_0626	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Xcel_0627	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Xcel_0628	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Xcel_0629	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Xcel_0630	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Xcel_0631	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Xcel_0632	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Xcel_0633	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Xcel_0634	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Xcel_0635	ENOG41082SA	50s ribosomal protein l29
Xcel_0636	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Xcel_0637	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Xcel_0638	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Xcel_0639	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Xcel_0640	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Xcel_0641	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Xcel_0642	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Xcel_0644	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Xcel_0645	ENOG410849U	50S ribosomal protein L30
Xcel_0646	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Xcel_0647	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Xcel_0648	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Xcel_0650	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Xcel_0651	ENOG41067V7	50S ribosomal protein L36
Xcel_0652	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Xcel_0653	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Xcel_0654	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Xcel_0655	ENOG4108ZT0	50S ribosomal protein l17
Xcel_0657	ENOG4105DFK	Polyphosphate glucokinase
Xcel_0658	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Xcel_0661	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Xcel_0662	ENOG4108UJD	30S ribosomal protein S9
Xcel_0664	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Xcel_0666	ENOG4105CS9	pantothenic acid kinase
Xcel_0667	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Xcel_0668	ENOG41082KK	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Xcel_0669	ENOG4105EQP	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity)
Xcel_0671	ENOG4108V06	Glutathione peroxidase
Xcel_0672	ENOG4108YBP	pseudouridine synthase
Xcel_0673	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Xcel_0674	ENOG4108097	ATP-binding protein
Xcel_0676	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
Xcel_0678	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
Xcel_0679	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Xcel_0681	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
Xcel_0684	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Xcel_0685	ENOG4105KIU	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Xcel_0686	ENOG4107X2D	transcriptional regulator, merr family
Xcel_0687	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Xcel_0689	ENOG4107QVP	Dehydrogenase
Xcel_0690	ENOG4105C26	Dehydrogenase
Xcel_0692	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Xcel_0696	ENOG4105C87	Aminotransferase class I and II
Xcel_0697	ENOG4105BZ1	(ABC) transporter
Xcel_0698	ENOG4105BZ1	(ABC) transporter
Xcel_0702	ENOG4105WX6	Membrane
Xcel_0705	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Xcel_0710	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0711	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Xcel_0712	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
Xcel_0717	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
Xcel_0718	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
Xcel_0719	ENOG4105D63	family UPF0324
Xcel_0724	ENOG4108AQF	aminoglycoside N(3)-acetyltransferase
Xcel_0725	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Xcel_0727	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Xcel_0729	ENOG4105D01	(LipO)protein
Xcel_0732	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
Xcel_0733	ENOG4108UMI	ABC transporter, permease
Xcel_0739	ENOG4108EQM	faD-dependent pyridine nucleotide-disulfide oxidoreductase
Xcel_0741	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Xcel_0742	ENOG4107T94	Endo-14-beta-xylanase
Xcel_0743	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Xcel_0745	ENOG4105NPE	arsR family transcriptional regulator
Xcel_0750	ENOG4105C2J	ABC transporter
Xcel_0753	ENOG4108HWW	ABC transporter
Xcel_0754	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Xcel_0755	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Xcel_0758	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Xcel_0759	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_0760	ENOG4105BZU	Histidine kinase
Xcel_0761	ENOG4105CJ1	ABC, transporter
Xcel_0766	ENOG4105CJW	magnesium transporter
Xcel_0769	ENOG4107T6F	Xaa-Pro aminopeptidase
Xcel_0771	ENOG4105DB7	PHP domain protein
Xcel_0772	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
Xcel_0774	ENOG4105C1J	atp-dependent rna helicase
Xcel_0777	ENOG4107R3N	Filamentation induced by cAMP protein fic
Xcel_0784	ENOG4105E09	nadh pyrophosphatase
Xcel_0788	ENOG4105WBQ	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Xcel_0792	ENOG41063PX	domain protein
Xcel_0793	ENOG4105DJZ	UPF0182 protein
Xcel_0815	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_0816	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_0822	ENOG4105YB8	TM2 domain containing protein
Xcel_0824	ENOG4105DR5	peptidase
Xcel_0830	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Xcel_0831	ENOG4105DBV	ornithine carbamoyltransferase
Xcel_0852	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_0865	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_0877	ENOG4105K5B	UPF0225 protein
Xcel_0878	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
Xcel_0879	ENOG41073R8	VanW family
Xcel_0880	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0881	ENOG4105C2J	ABC transporter
Xcel_0882	ENOG41071MT	Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane
Xcel_0883	ENOG4105CNN	ABC, transporter
Xcel_0884	ENOG4105D4B	ABC, transporter
Xcel_0888	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0889	ENOG41080R8	Conserved Protein
Xcel_0890	ENOG4107QR9	Iron-sulfur cluster binding protein
Xcel_0891	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Xcel_0898	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Xcel_0899	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Xcel_0907	ENOG4108UHU	Aldolase
Xcel_0908	ENOG4105D7K	pfkb domain protein
Xcel_0909	ENOG4105DHU	Bile acid
Xcel_0913	ENOG4105C26	Dehydrogenase
Xcel_0916	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_0920	ENOG4105CNT	hydrolase family 2
Xcel_0922	ENOG4107R9S	Malate synthase
Xcel_0925	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
Xcel_0927	ENOG4108IAB	Phoh family
Xcel_0928	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
Xcel_0929	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Xcel_0932	ENOG4105C3U	ABC transporter
Xcel_0935	ENOG4105C9Q	fumarate hydratase class II
Xcel_0937	ENOG4105YX8	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Xcel_0939	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Xcel_0941	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Xcel_0946	ENOG4105C3G	gtp-binding protein
Xcel_0947	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
Xcel_0952	ENOG4108J59	Extracellular solute-binding protein, family 5
Xcel_0953	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Xcel_0954	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Xcel_0955	ENOG4105C3U	ABC transporter
Xcel_0956	ENOG4108JQ7	(ABC) transporter
Xcel_0961	ENOG4108JQ6	ABC transporter
Xcel_0962	ENOG4105CI3	gtp-binding protein typa
Xcel_0963	ENOG4108KZ5	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity)
Xcel_0967	ENOG4105CQC	Prephenate dehydratase
Xcel_0970	ENOG4108Z4U	Ferredoxin
Xcel_0976	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
Xcel_0977	ENOG4108URH	decarboxylase
Xcel_0978	ENOG4105EEI	dihydropteroate synthase
Xcel_0981	ENOG4105DU6	RNA polymerase
Xcel_0983	ENOG4105UTW	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
Xcel_0984	ENOG4105C31	Tryptophanyl-tRNA synthetase
Xcel_0987	ENOG4105E33	succinate dehydrogenase
Xcel_0992	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
Xcel_0993	ENOG4107RM1	amidohydrolase
Xcel_0994	ENOG4105DIH	basic membrane
Xcel_0995	ENOG4108JQ9	ABC transporter
Xcel_0996	ENOG4105UIB	(ABC) transporter
Xcel_1002	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
Xcel_1003	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Xcel_1005	ENOG4107QSU	Phosphoglucomutase phosphomannomutase alpha beta alpha domain
Xcel_1009	ENOG4107Y7Q	pfkb domain protein
Xcel_1012	ENOG4108JIK	carboxylase
Xcel_1013	ENOG4107WR6	Maf-like protein
Xcel_1021	ENOG4105D8K	carboxyl transferase
Xcel_1024	ENOG4108RAV	Conserved protein
Xcel_1025	ENOG4108KGH	TRANSCRIPTIONal
Xcel_1026	ENOG4108KGH	TRANSCRIPTIONal
Xcel_1034	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
Xcel_1035	ENOG4105CAK	Cell division ATP-binding protein ftsE
Xcel_1036	ENOG4107RYD	Part of the ABC transporter FtsEX involved in cellular division (By similarity)
Xcel_1038	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Xcel_1040	ENOG4105C10	Electron transfer flavoprotein
Xcel_1044	ENOG4105E2R	ROK family
Xcel_1046	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
Xcel_1048	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
Xcel_1049	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
Xcel_1053	ENOG4105E2V	Glycosyltransferase 36
Xcel_1054	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Xcel_1056	ENOG4105KEN	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
Xcel_1058	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Xcel_1059	ENOG4108RQ5	Beta-lactamase domain-containing protein
Xcel_1061	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Xcel_1062	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Xcel_1065	ENOG41080RH	Thioredoxin
Xcel_1066	ENOG4105KZX	Pterin carbinolamine dehydratase
Xcel_1069	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Xcel_1073	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Xcel_1075	ENOG4107QN1	sodium solute
Xcel_1079	ENOG4105E90	ABC transporter
Xcel_1080	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
Xcel_1081	ENOG4108IJ8	ABC transporter
Xcel_1083	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
Xcel_1086	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Xcel_1091	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Xcel_1094	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
Xcel_1099	ENOG4105CI1	PTS System
Xcel_1100	ENOG4105D8X	mechanosensitive ion channel
Xcel_1104	ENOG4105C9K	Endothelin-converting enzyme 1
Xcel_1108	ENOG4105DYW	oxidoreductase
Xcel_1110	ENOG4105D7W	serine acetyltransferase
Xcel_1118	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Xcel_1119	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Xcel_1120	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Xcel_1121	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Xcel_1123	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
Xcel_1126	ENOG4105EAB	amino acid AbC transporter
Xcel_1127	ENOG4105DRP	amino acid AbC transporter
Xcel_1128	ENOG4105CDA	abc transporter atp-binding protein
Xcel_1131	ENOG41088YA	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)
Xcel_1136	ENOG4108KPJ	rna polymerase sigma factor
Xcel_1140	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Xcel_1148	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Xcel_1149	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Xcel_1150	ENOG41065HY	1,4-beta-cellobiosidase
Xcel_1151	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_1153	ENOG4105CYP	glycoside hydrolase, family
Xcel_1154	ENOG4105CMT	Dihydroxyacetone kinase
Xcel_1155	ENOG4108UTZ	Dihydroxyacetone kinase
Xcel_1158	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Xcel_1159	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Xcel_1161	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Xcel_1164	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Xcel_1167	ENOG4105K5M	30s ribosomal protein S16
Xcel_1168	ENOG41082KU	UPF0109 protein
Xcel_1169	ENOG4107XUM	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Xcel_1170	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Xcel_1171	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Xcel_1172	ENOG4107QYR	Signal peptidase i
Xcel_1173	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Xcel_1175	ENOG41080R2	UPF0102 protein
Xcel_1176	ENOG4105C0P	Mg chelatase subunit ChlI
Xcel_1178	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Xcel_1180	ENOG4105CE9	30S ribosomal protein S2
Xcel_1181	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Xcel_1182	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Xcel_1183	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Xcel_1184	ENOG4105KNE	Phosphatidate cytidylyltransferase
Xcel_1185	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Xcel_1189	ENOG4105I1K	ABC transporter
Xcel_1194	ENOG4105CJQ	hydrolase, family 31
Xcel_1200	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Xcel_1201	ENOG4105DZP	Membrane-associated zinc metalloprotease
Xcel_1202	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Xcel_1206	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Xcel_1208	ENOG4107Z1I	Required for maturation of 30S ribosomal subunits (By similarity)
Xcel_1211	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Xcel_1212	ENOG4107ZPY	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Xcel_1213	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Xcel_1216	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Xcel_1217	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Xcel_1218	ENOG4105C1V	Peptidase, M16
Xcel_1219	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Xcel_1230	ENOG4105CN5	Metallo-Beta-Lactamase
Xcel_1234	ENOG4107QZI	cell division protein FtsK
Xcel_1237	ENOG4105CEV	competence damage-inducible protein
Xcel_1238	ENOG4105WBV	Transcriptional regulator
Xcel_1239	ENOG4108S0J	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity)
Xcel_1240	ENOG4107QRT	dEAD DEAH box helicase
Xcel_1242	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Xcel_1243	ENOG4105KC9	Modulates RecA activity (By similarity)
Xcel_1244	ENOG4105DRP	amino acid AbC transporter
Xcel_1245	ENOG4108Q1T	ABC transporter
Xcel_1246	ENOG4107UBR	Extracellular solute-binding protein family 3
Xcel_1247	ENOG4105CDA	abc transporter atp-binding protein
Xcel_1248	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Xcel_1252	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Xcel_1253	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Xcel_1254	ENOG4107Y49	methyltransferase
Xcel_1255	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Xcel_1258	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Xcel_1259	ENOG41067Z0	domain protein
Xcel_1260	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Xcel_1261	ENOG4108JQ1	Dehydrogenase
Xcel_1264	ENOG4105BZU	Histidine kinase
Xcel_1267	ENOG4105VEQ	Cold shock protein
Xcel_1270	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Xcel_1274	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Xcel_1275	ENOG4108V6E	Cell division protein mraZ
Xcel_1276	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Xcel_1278	ENOG4105CJN	penicillin-binding protein
Xcel_1281	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Xcel_1282	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Xcel_1284	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Xcel_1285	ENOG4105DFU	Cell wall formation (By similarity)
Xcel_1287	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Xcel_1288	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Xcel_1289	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
Xcel_1291	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
Xcel_1292	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Xcel_1296	ENOG4105C0B	DNA polymerase III (alpha subunit)
Xcel_1301	ENOG4105WQ3	Rna-binding protein
Xcel_1302	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Xcel_1303	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Xcel_1305	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Xcel_1307	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Xcel_1308	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Xcel_1310	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Xcel_1311	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Xcel_1316	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Xcel_1317	ENOG41084BS	50S ribosomal protein L35
Xcel_1318	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Xcel_1319	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Xcel_1321	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Xcel_1322	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Xcel_1323	ENOG4105DT9	hydrolase family 43
Xcel_1325	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Xcel_1327	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Xcel_1328	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Xcel_1329	ENOG4105CAS	nag kinase
Xcel_1330	ENOG4105C8Y	Acetylornithine aminotransferase
Xcel_1332	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
Xcel_1333	ENOG4105CH7	arginosuccinase
Xcel_1334	ENOG4105DBI	uridine monophosphokinase
Xcel_1335	ENOG4108VX5	3-methyladenine DNA glycosylase
Xcel_1336	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Xcel_1338	ENOG4105DSU	hydrolase
Xcel_1342	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Xcel_1347	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Xcel_1353	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Xcel_1355	ENOG4105CJ1	ABC, transporter
Xcel_1358	ENOG4105JRK	feS assembly protein SufD
Xcel_1360	ENOG4105C3K	feS assembly ATPase SufC
Xcel_1362	ENOG4108UNV	SUF system FeS assembly protein, NifU family
Xcel_1363	ENOG4105VG1	fes assembly suf system protein
Xcel_1369	ENOG4105EG2	ABC transporter, permease
Xcel_1370	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Xcel_1389	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Xcel_1394	ENOG4105DHS	permease protein
Xcel_1395	ENOG4105CM4	permease protein
Xcel_1396	ENOG4108IPW	abc transporter atp-binding protein
Xcel_1398	ENOG4107ZXU	DSBA oxidoreductase
Xcel_1399	ENOG4105BZ4	penicillin-binding protein
Xcel_1402	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
Xcel_1411	ENOG4105C5H	ABC transporter
Xcel_1416	ENOG4105CHR	reductase
Xcel_1420	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Xcel_1421	ENOG4107QPH	glycogen) synthase
Xcel_1424	ENOG4105F44	Two component transcriptional regulator, winged helix family
Xcel_1425	ENOG4106F60	Histidine kinase
Xcel_1427	ENOG4105DKW	ABC transporter
Xcel_1441	ENOG4105C0B	DNA polymerase III (alpha subunit)
Xcel_1445	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
Xcel_1447	ENOG4105E93	esterase
Xcel_1448	ENOG4105E0A	ABC, transporter
Xcel_1449	ENOG4105TVJ	transport system, permease
Xcel_1450	ENOG4105DQ5	transport system permease protein
Xcel_1451	ENOG4105PEC	Iron-enterobactin transporter periplasmic binding protein
Xcel_1453	ENOG4105DWF	phosphomethylpyrimidine kinase
Xcel_1455	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Xcel_1456	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Xcel_1458	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Xcel_1460	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_1471	ENOG4105D9U	N-acetyltransferase
Xcel_1472	ENOG4105C5H	ABC transporter
Xcel_1473	ENOG4105DGW	oligopeptidase A
Xcel_1474	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Xcel_1477	ENOG4105CV8	reductase
Xcel_1479	ENOG4105C8N	cysteinyl-tRNA synthetase
Xcel_1481	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
Xcel_1485	ENOG4105DHM	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity)
Xcel_1486	ENOG4105E5F	proteasome
Xcel_1487	ENOG4105WFD	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)
Xcel_1488	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Xcel_1489	ENOG4105F7N	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
Xcel_1490	ENOG4105DVV	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)
Xcel_1492	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Xcel_1493	ENOG4105BZ1	(ABC) transporter
Xcel_1494	ENOG4105BZ1	(ABC) transporter
Xcel_1499	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Xcel_1500	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Xcel_1501	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Xcel_1502	ENOG4107TBN	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Xcel_1503	ENOG4105CBC	glutamate synthase
Xcel_1515	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Xcel_1516	ENOG4105ECP	epimerase
Xcel_1517	ENOG4105BZ1	(ABC) transporter
Xcel_1520	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Xcel_1529	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Xcel_1544	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Xcel_1545	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Xcel_1546	ENOG4105CHW	UPF0052 protein
Xcel_1547	ENOG4105CIE	May be required for sporulation (By similarity)
Xcel_1548	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Xcel_1549	ENOG4105BZA	Phosphoglycerate kinase
Xcel_1550	ENOG4105CP7	Triose-phosphate isomerase
Xcel_1553	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
Xcel_1556	ENOG4107QQX	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Xcel_1558	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Xcel_1562	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Xcel_1563	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Xcel_1565	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Xcel_1582	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_1589	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_1604	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Xcel_1606	ENOG4105KAK	Plasmid pRiA4b ORF-3 family protein
Xcel_1615	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_1616	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_1617	ENOG4105BZU	Histidine kinase
Xcel_1618	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_1619	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_1620	ENOG4105BZU	Histidine kinase
Xcel_1624	ENOG4107QZF	nitrite reductase NADPH large subunit
Xcel_1625	ENOG4107QZF	nitrite reductase NADPH large subunit
Xcel_1626	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Xcel_1627	ENOG4107ZBN	O-methyltransferase
Xcel_1632	ENOG4108IG5	Transcriptional regulator
Xcel_1633	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_1634	ENOG4105BZU	Histidine kinase
Xcel_1641	ENOG4105CEI	nitrite reductase
Xcel_1645	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Xcel_1646	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Xcel_1656	ENOG4105C22	threonyL-tRNA synthetase
Xcel_1659	ENOG4107YQ3	lipid a biosynthesis lauroyl acyltransferase
Xcel_1660	ENOG4105E2K	Glycosyl transferase (Group 1
Xcel_1662	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Xcel_1663	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Xcel_1664	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Xcel_1665	ENOG4105CDY	transcriptional regulatory protein
Xcel_1666	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Xcel_1667	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Xcel_1668	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Xcel_1670	ENOG4107RSV	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Xcel_1671	ENOG4107RTU	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Xcel_1672	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Xcel_1673	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Xcel_1675	ENOG4105DQE	DNA ligase
Xcel_1677	ENOG4105C99	atpase involved in dna repair
Xcel_1679	ENOG4105C5X	domain protein
Xcel_1680	ENOG4105CUT	histidyl-tRNA synthetase
Xcel_1682	ENOG4105C9M	aspartyl-trna synthetase
Xcel_1686	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Xcel_1689	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Xcel_1690	ENOG41080G3	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Xcel_1693	ENOG4105E2X	shikimate dehydrogenase
Xcel_1694	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Xcel_1695	ENOG4105D49	3-dehydroquinate synthase
Xcel_1696	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
Xcel_1699	ENOG4105DMF	Dehydrogenase
Xcel_1702	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Xcel_1705	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Xcel_1706	ENOG410803B	Involved in the transcription termination process (By similarity)
Xcel_1707	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Xcel_1708	ENOG4105CXT	aspartate transcarbamylase
Xcel_1709	ENOG4105CD3	dihydroorotase
Xcel_1711	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Xcel_1712	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Xcel_1713	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
Xcel_1714	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Xcel_1716	ENOG4105MTQ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Xcel_1718	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Xcel_1722	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Xcel_1725	ENOG4105DJV	ribulose-phosphate 3-epimerase
Xcel_1728	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Xcel_1729	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Xcel_1730	ENOG4105M0N	phosphoribosyl-ATP pyrophosphatase
Xcel_1731	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Xcel_1738	ENOG4108UW8	fha domain-containing protein
Xcel_1742	ENOG4107T8T	UPF0173 metal-dependent hydrolase
Xcel_1748	ENOG4105EC3	peptidase S51, dipeptidase E
Xcel_1760	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Xcel_1762	ENOG4105ECQ	AraC Family Transcriptional Regulator
Xcel_1767	ENOG4105CDH	Citrulline--aspartate ligase
Xcel_1771	ENOG4105DCF	alanine dehydrogenase
Xcel_1773	ENOG41079Y2	Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone
Xcel_1775	ENOG4107R05	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Xcel_1776	ENOG4105CI2	imidazolone-5-propionate hydrolase
Xcel_1778	ENOG4105CBD	Diacylglycerol kinase
Xcel_1779	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Xcel_1780	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Xcel_1783	ENOG4108FFZ	Transcriptional regulator
Xcel_1787	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Xcel_1791	ENOG4105DPV	During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction
Xcel_1793	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Xcel_1795	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
Xcel_1796	ENOG4105DUM	transcriptional regulator, lysR family
Xcel_1798	ENOG4107R3N	Filamentation induced by cAMP protein fic
Xcel_1805	ENOG4105BZ1	(ABC) transporter
Xcel_1806	ENOG4105BZ1	(ABC) transporter
Xcel_1814	ENOG4107QZF	nitrite reductase NADPH large subunit
Xcel_1815	ENOG4107QZF	nitrite reductase NADPH large subunit
Xcel_1818	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Xcel_1820	ENOG4108IFG	nitrite reductase, (NAD(P)H)
Xcel_1821	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Xcel_1822	ENOG4105DQQ	Major facilitator superfamily MFS_1
Xcel_1825	ENOG4108IUE	nitrate reductase beta subunit
Xcel_1839	ENOG4107RWR	Sodium hydrogen exchanger
Xcel_1840	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
Xcel_1841	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Xcel_1846	ENOG4105D65	subunit l
Xcel_1847	ENOG4108JQ7	(ABC) transporter
Xcel_1849	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Xcel_1850	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Xcel_1854	ENOG4105CJ1	ABC, transporter
Xcel_1856	ENOG4108IQE	Amp-dependent synthetase and ligase
Xcel_1861	ENOG4105DBV	ornithine carbamoyltransferase
Xcel_1862	ENOG4105TMB	Formate nitrite transporter
Xcel_1863	ENOG4108M3P	Membrane
Xcel_1865	ENOG4105NPE	arsR family transcriptional regulator
Xcel_1882	ENOG4105CSR	polyphosphate kinase 2
Xcel_1883	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Xcel_1889	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
Xcel_1891	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
Xcel_1892	ENOG4105CHU	acetyl-coa acetyltransferase
Xcel_1893	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Xcel_1894	ENOG4105F1A	Pyruvate formate-lyase
Xcel_1896	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
Xcel_1900	ENOG4105EEM	helicase
Xcel_1901	ENOG4105P8F	nudix hydrolase
Xcel_1903	ENOG4105MDH	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
Xcel_1906	ENOG4108M15	ABC transporter
Xcel_1909	ENOG4107QM5	aconitate hydratase
Xcel_1914	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Xcel_1916	ENOG4105C0X	amino acid
Xcel_1917	ENOG4107VEG	TrkA-N domain protein
Xcel_1922	ENOG4107ZFB	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Xcel_1926	ENOG4105EN6	Membrane
Xcel_1929	ENOG4107W53	thymidine kinase
Xcel_1934	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Xcel_1940	ENOG4105C3R	Methionine synthase
Xcel_1969	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Xcel_1973	ENOG4105CEY	Amp-dependent synthetase and ligase
Xcel_1978	ENOG4108UZX	fmn reductase
Xcel_1979	ENOG4105MXW	flavin reductase domain protein, FMN-binding
Xcel_1982	ENOG4105VMP	Transcriptional regulator
Xcel_1984	ENOG4105CHP	RNA polymerase
Xcel_1988	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Xcel_1991	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Xcel_1992	ENOG4105SHT	UspA domain-containing protein
Xcel_1995	ENOG4105EAH	synthase
Xcel_1998	ENOG4105C7V	phospho-2-dehydro-3-deoxyheptonate aldolase
Xcel_2002	ENOG4105DKQ	ROK family
Xcel_2006	ENOG4108I0Q	anthranilate phosphoribosyltransferase
Xcel_2008	ENOG4105CCU	oxidase (Subunit III)
Xcel_2009	ENOG4107UDY	cytochrome C
Xcel_2010	ENOG4107EUI	c reductase, iron-sulfur
Xcel_2011	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Xcel_2014	ENOG4105MCD	Part of cytochrome c oxidase, its function is
Xcel_2015	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Xcel_2016	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
Xcel_2021	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Xcel_2023	ENOG4105CPC	Aldo Keto reductase
Xcel_2026	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Xcel_2029	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Xcel_2033	ENOG4105D9R	oxidoreductase
Xcel_2034	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Xcel_2035	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Xcel_2038	ENOG4105C5F	glutamine synthetase
Xcel_2042	ENOG4108YIQ	Alpha beta hydrolase
Xcel_2043	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Xcel_2046	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
Xcel_2047	ENOG4105C5F	glutamine synthetase
Xcel_2051	ENOG4105FEU	K -dependent Na -Ca exchanger
Xcel_2082	ENOG4107XFJ	UPF0246 protein
Xcel_2083	ENOG4105CVJ	phosphoglycerate mutase
Xcel_2085	ENOG4105EGD	dinuclear metal center protein, YbgI family
Xcel_2086	ENOG4105CHH	sulfate transporter
Xcel_2090	ENOG4105C9U	ATP-dependent DNA helicase RecQ
Xcel_2094	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Xcel_2098	ENOG4105CPP	Dehydrogenase, E1 component
Xcel_2099	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
Xcel_2100	ENOG4107QX3	carboxylase
Xcel_2102	ENOG4105C1G	acyl-Coa dehydrogenase
Xcel_2105	ENOG4105D6N	CoA-transferase, subunit a
Xcel_2111	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Xcel_2119	ENOG4105CG3	alpha amylase, catalytic region
Xcel_2121	ENOG4105DKQ	ROK family
Xcel_2122	ENOG4105FDP	GntR family transcriptional regulator
Xcel_2123	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
Xcel_2129	ENOG4105DVT	helicase
Xcel_2132	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Xcel_2136	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Xcel_2137	ENOG41082KT	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Xcel_2138	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Xcel_2143	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Xcel_2147	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
Xcel_2152	ENOG4107FKK	extracellular solute-binding protein family 1
Xcel_2154	ENOG4105EG2	ABC transporter, permease
Xcel_2155	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2157	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Xcel_2158	ENOG4105CG3	alpha amylase, catalytic region
Xcel_2159	ENOG4107R28	alpha amylase, catalytic region
Xcel_2160	ENOG4105EG2	ABC transporter, permease
Xcel_2161	ENOG4105D56	permease protein
Xcel_2164	ENOG4105CG3	alpha amylase, catalytic region
Xcel_2167	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Xcel_2168	ENOG4105DSE	periplasmic solute binding protein
Xcel_2169	ENOG4105FDK	ABC transporter
Xcel_2172	ENOG4105DQ5	transport system permease protein
Xcel_2173	ENOG4105TVJ	transport system, permease
Xcel_2174	ENOG4105E0A	ABC, transporter
Xcel_2176	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Xcel_2177	ENOG4106DBE	Involved in DNA repair and RecF pathway recombination (By similarity)
Xcel_2178	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Xcel_2179	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Xcel_2180	ENOG4105WBV	Transcriptional regulator
Xcel_2182	ENOG4107QXN	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Xcel_2185	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Xcel_2187	ENOG4107VNR	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Xcel_2189	ENOG4107YU2	histidine triad (hIT) protein
Xcel_2191	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Xcel_2192	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Xcel_2194	ENOG4107SM8	Adenylate Guanylate cyclase
Xcel_2200	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Xcel_2207	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Xcel_2210	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
Xcel_2214	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Xcel_2216	ENOG4105EPR	degv family
Xcel_2217	ENOG4105D7A	ATP-binding protein
Xcel_2223	ENOG4105C8T	Leucyl-tRNA synthetase
Xcel_2225	ENOG4105F27	Major Facilitator
Xcel_2229	ENOG4105FDF	Could be involved in DNA repair (By similarity)
Xcel_2234	ENOG4105CHP	RNA polymerase
Xcel_2235	ENOG4105GRZ	Ycii-related protein
Xcel_2241	ENOG4105DWT	malate dehydrogenase (quinone)
Xcel_2242	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
Xcel_2245	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Xcel_2246	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Xcel_2249	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Xcel_2250	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
Xcel_2252	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Xcel_2254	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Xcel_2255	ENOG41079KZ	Major Facilitator Superfamily
Xcel_2256	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Xcel_2258	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Xcel_2259	ENOG4105K46	50S ribosomal protein l27
Xcel_2260	ENOG410826X	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Xcel_2261	ENOG4105C94	Transporter
Xcel_2263	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
Xcel_2265	ENOG4107104	thymidine kinase
Xcel_2266	ENOG4105C03	ribonuclease
Xcel_2267	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Xcel_2268	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Xcel_2269	ENOG4108JJ9	ABC, transporter
Xcel_2270	ENOG4108JJ8	(ABC) transporter
Xcel_2272	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Xcel_2273	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Xcel_2274	ENOG41084BZ	50S ribosomal protein L32
Xcel_2278	ENOG4106H78	methyltransferase
Xcel_2280	ENOG4105DP4	dak2 domain fusion protein ylov
Xcel_2281	ENOG4105VB9	50S ribosomal protein l28
Xcel_2285	ENOG4105CPF	Cell wall formation (By similarity)
Xcel_2287	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Xcel_2288	ENOG4105DCM	major facilitator superfamily
Xcel_2292	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Xcel_2294	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Xcel_2295	ENOG4105CSH	Transporter
Xcel_2296	ENOG4105D82	Glutamate dehydrogenase
Xcel_2299	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
Xcel_2300	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
Xcel_2302	ENOG4105VG5	Membrane
Xcel_2306	ENOG4105EHG	Permease protein
Xcel_2307	ENOG4105E0A	ABC, transporter
Xcel_2311	ENOG4105KVH	Transcriptional regulator
Xcel_2312	ENOG410839S	Toxic component of a toxin-antitoxin (TA) module (By similarity)
Xcel_2324	ENOG4105C0D	helicase
Xcel_2325	ENOG4105ENA	helicase
Xcel_2340	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
Xcel_2353	ENOG4105DYW	oxidoreductase
Xcel_2355	ENOG41073TP	transcriptional regulator
Xcel_2356	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Xcel_2357	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Xcel_2358	ENOG41069M3	Transcriptional regulator
Xcel_2363	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Xcel_2366	ENOG4105ERH	Fumarylacetoacetate hydrolase
Xcel_2376	ENOG4108Z66	YbaK ebsC protein
Xcel_2377	ENOG410901E	Membrane
Xcel_2378	ENOG4105DFA	alanine racemase domain protein
Xcel_2380	ENOG4108594	Permease of the drug metabolite transporter
Xcel_2381	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Xcel_2382	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Xcel_2383	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Xcel_2384	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Xcel_2385	ENOG4108ZP8	Acetolactate synthase small subunit
Xcel_2387	ENOG4105KZX	Pterin carbinolamine dehydratase
Xcel_2389	ENOG4105C01	Dihydroxy-acid dehydratase
Xcel_2390	ENOG4105C01	Dihydroxy-acid dehydratase
Xcel_2392	ENOG4105UA4	acetyltransferase
Xcel_2393	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Xcel_2394	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Xcel_2395	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Xcel_2399	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
Xcel_2400	ENOG4105CNN	ABC, transporter
Xcel_2401	ENOG4105C2J	ABC transporter
Xcel_2402	ENOG4105E2R	ROK family
Xcel_2404	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Xcel_2405	ENOG4108EKI	Dehydrogenase
Xcel_2408	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Xcel_2411	ENOG4105C10	Electron transfer flavoprotein
Xcel_2417	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
Xcel_2419	ENOG41070F3	Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity)
Xcel_2420	ENOG4105C7N	Xanthine uracil vitamin C permease
Xcel_2421	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
Xcel_2426	ENOG4107S9D	Alpha beta hydrolase
Xcel_2432	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Xcel_2436	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Xcel_2437	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Xcel_2438	ENOG4105G3E	Probably involved in ribonucleotide reductase function (By similarity)
Xcel_2442	ENOG4105CE4	GlcNAc 6-P deacetylase
Xcel_2445	ENOG4105CYV	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity)
Xcel_2447	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Xcel_2448	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Xcel_2449	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Xcel_2450	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Xcel_2451	ENOG4108T62	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Xcel_2452	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
Xcel_2454	ENOG4107UH5	it plays a direct role in the translocation of protons across the membrane (By similarity)
Xcel_2456	ENOG4105ESV	Glycosyl transferase, family 4
Xcel_2458	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Xcel_2459	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Xcel_2460	ENOG4105VFB	Binds the 23S rRNA (By similarity)
Xcel_2461	ENOG4105JNK	Glycosyl transferase (Group 1
Xcel_2463	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Xcel_2464	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Xcel_2465	ENOG4105D6E	homoserine dehydrogenase
Xcel_2467	ENOG4105C75	arginyL-tRNA synthetase
Xcel_2472	ENOG4105CNN	ABC, transporter
Xcel_2473	ENOG4105C2J	ABC transporter
Xcel_2479	ENOG4105CR4	methylisocitrate lyase
Xcel_2484	ENOG4105C37	(CBS) domain
Xcel_2485	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Xcel_2486	ENOG4105EB3	Histidine kinase
Xcel_2487	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Xcel_2488	ENOG4105CPC	Aldo Keto reductase
Xcel_2489	ENOG4107WI4	Aldose-1-epimerase
Xcel_2492	ENOG4105EMN	RNA polymerase sigma factor
Xcel_2494	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Xcel_2496	ENOG4107TK4	histidinol-phosphate phosphatase
Xcel_2498	ENOG4105CT4	transporter
Xcel_2505	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Xcel_2506	ENOG4105T0Z	Conserved Protein
Xcel_2507	ENOG4108S7Q	sigma 54 modulation protein ribosomal protein S30ea
Xcel_2509	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_2510	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_2512	ENOG4108T3R	lipoprotein lpqB
Xcel_2513	ENOG4105BZU	Histidine kinase
Xcel_2514	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Xcel_2517	ENOG4108WQ6	secreted protein
Xcel_2518	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Xcel_2526	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Xcel_2530	ENOG4108HQS	Glycine betaine
Xcel_2533	ENOG4105CTX	dehydratase
Xcel_2534	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2535	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Xcel_2536	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Xcel_2538	ENOG4105CHR	reductase
Xcel_2539	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
Xcel_2540	ENOG4105F5H	Glycosyl Hydrolase Family 88
Xcel_2541	ENOG4105W49	UPF0434 protein
Xcel_2542	ENOG4107QKV	phosphomannomutase
Xcel_2543	ENOG4105EIP	mannose-6-phosphate isomerase
Xcel_2549	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Xcel_2557	ENOG4107QPT	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
Xcel_2560	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
Xcel_2563	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Xcel_2568	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
Xcel_2572	ENOG4105EY8	ABC transporter
Xcel_2574	ENOG410602S	Transferase
Xcel_2583	ENOG4105K64	Glycosyl transferase, family 2
Xcel_2584	ENOG4107QRS	glycosyltransferase group 2 family protein
Xcel_2586	ENOG4105EY8	ABC transporter
Xcel_2589	ENOG4105KPE	licD family
Xcel_2590	ENOG4107RZX	Teichoic acid biosynthesis protein
Xcel_2591	ENOG4108NMT	An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity)
Xcel_2594	ENOG4108KGH	TRANSCRIPTIONal
Xcel_2595	ENOG4108KGH	TRANSCRIPTIONal
Xcel_2596	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Xcel_2598	ENOG41065SU	Two-component system sensor kinase
Xcel_2599	ENOG4105ETX	regulatoR
Xcel_2601	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_2603	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_2606	ENOG4105EC2	ftsk spoIIIe
Xcel_2613	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
Xcel_2615	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2616	ENOG4105E2V	Glycosyltransferase 36
Xcel_2617	ENOG4105C26	Dehydrogenase
Xcel_2621	ENOG4105D82	Glutamate dehydrogenase
Xcel_2622	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Xcel_2623	ENOG4107JTW	chlorite dismutase
Xcel_2624	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Xcel_2626	ENOG4105BZW	Glycerate kinase
Xcel_2627	ENOG4105EYF	MMPL domain protein
Xcel_2629	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Xcel_2631	ENOG4107QPI	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Xcel_2633	ENOG4105T1M	mycothiol conjugate amidase mca
Xcel_2635	ENOG4107YD5	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Xcel_2636	ENOG4105C7B	Threonine dehydratase
Xcel_2640	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Xcel_2642	ENOG4107RYT	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
Xcel_2646	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
Xcel_2648	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
Xcel_2649	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Xcel_2650	ENOG4105D2H	Uronic isomerase
Xcel_2655	ENOG4105DET	Rhamnulokinase
Xcel_2656	ENOG4107QZW	Altronate oxidoreductase
Xcel_2657	ENOG4105DDC	Oxidoreductase domain protein
Xcel_2659	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2661	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Xcel_2666	ENOG4105DEI	Mannitol dehydrogenase
Xcel_2667	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
Xcel_2668	ENOG4105EGE	secreted protein
Xcel_2670	ENOG4105BZP	glycoside hydrolase 15-related
Xcel_2675	ENOG4105DXB	Major Facilitator superfamily
Xcel_2682	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Xcel_2683	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
Xcel_2690	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
Xcel_2692	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
Xcel_2700	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Xcel_2704	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Xcel_2705	ENOG4107XT7	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Xcel_2708	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Xcel_2709	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Xcel_2710	ENOG4108IG5	Transcriptional regulator
Xcel_2711	ENOG4108IUX	(ABC) transporter
Xcel_2712	ENOG4105RHA	ABC transporter, permease
Xcel_2713	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
Xcel_2714	ENOG4105DJ2	Major Facilitator Superfamily
Xcel_2716	ENOG4105BZU	Histidine kinase
Xcel_2717	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_2722	ENOG4105C5H	ABC transporter
Xcel_2723	ENOG4105I82	acetyl xylan esterase
Xcel_2724	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Xcel_2725	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Xcel_2730	ENOG4105F8V	Hydrolase, tatD family
Xcel_2731	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Xcel_2732	ENOG4105D8V	Glucose sorbosone dehydrogenase
Xcel_2734	ENOG4108RWI	nicotinamidase
Xcel_2737	ENOG4105E2D	ec 3.2.1.52
Xcel_2749	ENOG4108I5D	sulfate abc transporter
Xcel_2750	ENOG4105F38	ABC transporter, permease
Xcel_2751	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Xcel_2753	ENOG41060NJ	transcriptional regulator
Xcel_2755	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
Xcel_2760	ENOG4105EHG	Permease protein
Xcel_2761	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Xcel_2766	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Xcel_2767	ENOG4105DE4	1-phosphofructokinase
Xcel_2768	ENOG4105DQV	Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)
Xcel_2780	ENOG41086D8	Transcriptional regulator
Xcel_2782	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
Xcel_2783	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2786	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
Xcel_2793	ENOG4105C37	(CBS) domain
Xcel_2798	ENOG4105CG3	alpha amylase, catalytic region
Xcel_2799	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2803	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_2804	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_2813	ENOG41080UU	5-formyltetrahydrofolate cyclo-ligase
Xcel_2817	ENOG41080FJ	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Xcel_2822	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_2826	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
Xcel_2827	ENOG4105C93	Xylose Isomerase
Xcel_2833	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
Xcel_2834	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
Xcel_2841	ENOG4105XT2	Transcriptional regulator
Xcel_2846	ENOG4107R8H	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Xcel_2847	ENOG4107SFI	Major Facilitator superfamily
Xcel_2848	ENOG4107SFI	Major Facilitator superfamily
Xcel_2849	ENOG4105XMC	MarR family Transcriptional regulator
Xcel_2850	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Xcel_2855	ENOG4105CB5	ATP-dependent DNA helicase recG
Xcel_2867	ENOG4105C7K	acetolactate synthase
Xcel_2887	ENOG4107YJ4	chain length determinant protein
Xcel_2896	ENOG4105J1P	transposase, IS3 IS911 family protein
Xcel_2900	ENOG4105K64	Glycosyl transferase, family 2
Xcel_2903	ENOG4105E2K	Glycosyl transferase (Group 1
Xcel_2906	ENOG4105D3Q	Sugar transferase
Xcel_2911	ENOG4105ETE	Transcriptional regulator (LacI family
Xcel_2912	ENOG4105I1K	ABC transporter
Xcel_2913	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
Xcel_2919	ENOG4107PBH	Toxic component of a toxin-antitoxin (TA) module. A
Xcel_2925	ENOG4105C7N	Xanthine uracil vitamin C permease
Xcel_2926	ENOG4105D3Q	Sugar transferase
Xcel_2930	ENOG4105VEQ	Cold shock protein
Xcel_2932	ENOG4105CFI	type iii restriction protein res subunit
Xcel_2937	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Xcel_2938	ENOG4105BZU	Histidine kinase
Xcel_2941	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Xcel_2944	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
Xcel_2949	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
Xcel_2952	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Xcel_2953	ENOG4105C8N	cysteinyl-tRNA synthetase
Xcel_2957	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Xcel_2958	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Xcel_2959	ENOG4108VJ1	Transcriptional regulator (CarD family
Xcel_2961	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Xcel_2964	ENOG4107QJG	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Xcel_2965	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Xcel_2969	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Xcel_2970	ENOG4105BZU	Histidine kinase
Xcel_2971	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Xcel_2972	ENOG4107RPC	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Xcel_2973	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Xcel_2977	ENOG4105CRK	lysyL-tRNA synthetase
Xcel_2985	ENOG4105EEI	dihydropteroate synthase
Xcel_2986	ENOG4105EUJ	GTP cyclohydrolase i
Xcel_2987	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Xcel_2989	ENOG4107RD1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Xcel_2991	ENOG4105BZU	Histidine kinase
Xcel_2992	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Xcel_2993	ENOG4105C4Y	ABC transporter
Xcel_2994	ENOG4107RCV	ABC transporter, permease
Xcel_2995	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Xcel_2997	ENOG4105F0N	pyrophosphate phospho-hydrolase
Xcel_2998	ENOG4105E2A	Dehydrogenase
Xcel_2999	ENOG4105EQP	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity)
Xcel_3000	ENOG4105ZXU	NLP P60 protein
Xcel_3002	ENOG4105DWV	Homoserine O-trans-acetylase
Xcel_3005	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Xcel_3009	ENOG4105EIH	LPPG Fo 2-phospho-L-lactate transferase
Xcel_3010	ENOG4105YV1	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity)
Xcel_3014	ENOG4108DBC	nitroreductase
Xcel_3016	ENOG4105CQB	FAD linked oxidase domain protein
Xcel_3022	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Xcel_3028	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Xcel_3029	ENOG4108X6U	May play a role in the intracellular transport of hydrophobic ligands
Xcel_3035	ENOG4107NHD	transcriptional regulator
Xcel_3036	ENOG4105D74	hydrolase
Xcel_3041	ENOG4108JQC	penicillin-binding protein 1A
Xcel_3042	ENOG4105DIN	metallophosphoesterase
Xcel_3054	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
Xcel_3056	ENOG4105E0A	ABC, transporter
Xcel_3057	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_3058	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_3062	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
Xcel_3071	ENOG4107ZYJ	bioY protein
Xcel_3073	ENOG4105CHU	acetyl-coa acetyltransferase
Xcel_3074	ENOG4108JJB	ABC transporter
Xcel_3078	ENOG4105M6F	mutator MutT protein
Xcel_3080	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Xcel_3082	ENOG4105CMR	udp-glucose 4-epimerase
Xcel_3088	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Xcel_3091	ENOG4105CGH	5'-nucleotidase
Xcel_3094	ENOG4105TMB	Formate nitrite transporter
Xcel_3096	ENOG4108Z0R	Transferase
Xcel_3098	ENOG4108DBC	nitroreductase
Xcel_3100	ENOG4105E9K	Isocitrate dehydrogenase
Xcel_3103	ENOG4105K64	Glycosyl transferase, family 2
Xcel_3107	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Xcel_3114	ENOG4105CHR	reductase
Xcel_3118	ENOG4105C9B	Cysteine desulfurase
Xcel_3126	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Xcel_3127	ENOG410839H	phosphoribosylformylglycinamidine synthase
Xcel_3133	ENOG4105C8V	SAICAR synthetase
Xcel_3134	ENOG4105C12	Phosphoribosylglycinamide synthetase
Xcel_3138	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Xcel_3144	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Xcel_3146	ENOG4108W9Q	Endoglucanase (EC 3.2.1.4)
Xcel_3147	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Xcel_3148	ENOG4105EMU	Dehydrogenase
Xcel_3150	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Xcel_3154	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
Xcel_3155	ENOG4105CGK	Exodeoxyribonuclease III
Xcel_3156	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_3157	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Xcel_3161	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Xcel_3167	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Xcel_3176	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Xcel_3179	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_3181	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Xcel_3185	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Xcel_3186	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Xcel_3187	ENOG4105D65	subunit l
Xcel_3189	ENOG4105DHP	deoxycytidine triphosphate deaminase
Xcel_3190	ENOG4105EUB	pirin domain protein
Xcel_3195	ENOG4105EJ2	Transcriptional regulator
Xcel_3197	ENOG4108KQI	regulatory protein luxr
Xcel_3200	ENOG4105EY0	Xylose isomerase domain protein TIM barrel
Xcel_3201	ENOG410849S	phosphocarrier protein (HPr)
Xcel_3202	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
Xcel_3203	ENOG4105C5Y	PTS System
Xcel_3205	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Xcel_3206	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Xcel_3214	ENOG4105CV8	reductase
Xcel_3218	ENOG4105EYF	MMPL domain protein
Xcel_3220	ENOG4105E4J	Cytochrome c oxidase caa3-type, assembly factor ctag-related protein
Xcel_3221	ENOG4107RN0	branched-chain alpha-keto acid dehydrogenase subunit E2
Xcel_3222	ENOG4105CPP	Dehydrogenase, E1 component
Xcel_3224	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Xcel_3225	ENOG41082T9	Membrane
Xcel_3228	ENOG4107QTF	adenylosuccinate lyase
Xcel_3232	ENOG4107AQZ	Membrane
Xcel_3233	ENOG4107R33	ppx gppa phosphatase
Xcel_3235	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
Xcel_3236	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
Xcel_3237	ENOG4105EPJ	extracellular solute-binding protein family 1
Xcel_3240	ENOG41061P8	Persistence to inhibition of murein or DNA biosynthesis regulatory protein
Xcel_3241	ENOG4108KP7	hydrolase
Xcel_3242	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Xcel_3243	ENOG4107TE5	Lipid kinase
Xcel_3247	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
Xcel_3248	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Xcel_3249	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Xcel_3251	ENOG4107R3N	Filamentation induced by cAMP protein fic
Xcel_3254	ENOG4105D52	delta-aminolevulinic acid dehydratase
Xcel_3255	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Xcel_3257	ENOG4105VPX	protein, conserved in bacteria
Xcel_3262	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Xcel_3263	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Xcel_3266	ENOG4105VUH	addiction module killer protein
Xcel_3267	ENOG4105YES	addiction module antidote protein
Xcel_3268	ENOG4108426	dNA-binding protein
Xcel_3277	ENOG4107SM8	Adenylate Guanylate cyclase
Xcel_3280	ENOG4105HFS	5'-3' exonuclease
Xcel_3281	ENOG41085J0	Protein CrcB homolog
Xcel_3282	ENOG4105WMR	Protein CrcB homolog
Xcel_3285	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Xcel_3286	ENOG4105E9Z	Nad-dependent epimerase dehydratase
Xcel_3289	ENOG4108YYC	ycei family
Xcel_3293	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Xcel_3300	ENOG4105J1P	transposase, IS3 IS911 family protein
Xcel_3304	ENOG4105CIK	Amidinotransferase
Xcel_3312	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
Xcel_3316	ENOG4105CJW	magnesium transporter
Xcel_3320	ENOG4105CJ1	ABC, transporter
Xcel_3322	ENOG4108JJB	ABC transporter
Xcel_3326	ENOG4105WH1	Two component transcriptional regulator luxr family
Xcel_3333	ENOG4105D5Q	Arginine ornithine antiporter
Xcel_3335	ENOG4105KVH	Transcriptional regulator
Xcel_3337	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
Xcel_3339	ENOG4105CIR	epoxide hydrolase
Xcel_3341	ENOG4105C57	major facilitator superfamily
Xcel_3345	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Xcel_3346	ENOG41089UC	methyltransferase, type 11
Xcel_3347	ENOG4105KTU	Transcriptional regulator, arsr family
Xcel_3350	ENOG4105CDU	Replicative dna helicase
Xcel_3351	ENOG4105UQX	Mate efflux family protein
Xcel_3352	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Xcel_3353	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Xcel_3355	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
Xcel_3356	ENOG4105BZ4	penicillin-binding protein
Xcel_3357	ENOG4105BZ4	penicillin-binding protein
Xcel_3358	ENOG4105K7K	Transcriptional regulator
Xcel_3359	ENOG4105CZA	synthase
Xcel_3363	ENOG41062IR	nudix hydrolase
Xcel_3368	ENOG4105C3M	thioredoxin reductase
Xcel_3369	ENOG4105K63	Thioredoxin
Xcel_3370	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Xcel_3371	ENOG4105CPF	Cell wall formation (By similarity)
Xcel_3373	ENOG4107QJE	Chromosome Partitioning Protein
Xcel_3374	ENOG4107XUG	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Xcel_3376	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Xcel_3377	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Xcel_3378	ENOG4105XH8	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Xcel_3379	ENOG41084CH	50S ribosomal protein l34
Xcel_3393	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
Xcel_3415	ENOG4107QJE	Chromosome Partitioning Protein
Xcel_3419	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Xcel_3442	ENOG4105ZXU	NLP P60 protein
Xcel_3459	ENOG4105K51	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)
Xcel_3472	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Xcel_3478	ENOG4108RAV	Conserved protein