locus-tag	class	description
Xcel_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Xcel_0002	COG0592	DNA-directed DNA polymerase activity
Xcel_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Xcel_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Xcel_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Xcel_0006	COG0187	DNA topoisomerase II activity
Xcel_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Xcel_0015	COG3764	Sortase (surface protein transpeptidase)
Xcel_0019	COG0515	serine threonine protein kinase
Xcel_0020	COG0768	penicillin binding
Xcel_0023	COG1716	ATPase activity
Xcel_0028	COG1136	(ABC) transporter
Xcel_0028	COG0577	efflux transmembrane transporter activity
Xcel_0033	COG0702	epimerase
Xcel_0034	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Xcel_0039	COG0436	Aminotransferase
Xcel_0044	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcel_0044	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Xcel_0045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Xcel_0046	COG0509	glycine decarboxylation via glycine cleavage system
Xcel_0051	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Xcel_0053	COG0204	Acyl-transferase
Xcel_0053	COG0318	PFAM AMP-dependent synthetase and ligase
Xcel_0055	COG2818	Glycosylase
Xcel_0062	COG0366	Alpha amylase catalytic
Xcel_0064	COG4209	transmembrane transport
Xcel_0065	COG0395	ABC-type sugar transport system, permease component
Xcel_0066	COG0583	DNA-binding transcription factor activity
Xcel_0069	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Xcel_0071	COG0805	protein transport
Xcel_0074	COG1643	Atp-dependent helicase
Xcel_0077	COG4585	Histidine kinase
Xcel_0079	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xcel_0081	COG2376	Dihydroxyacetone kinase
Xcel_0082	COG1984	allophanate hydrolase subunit 2
Xcel_0083	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Xcel_0093	COG1132	(ABC) transporter
Xcel_0094	COG2197	response regulator
Xcel_0096	COG1131	(ABC) transporter
Xcel_0100	COG0765	amino acid transport
Xcel_0101	COG1126	abc transporter atp-binding protein
Xcel_0103	COG1278	Cold shock
Xcel_0109	COG1770	oligopeptidase
Xcel_0131	COG2329	Antibiotic biosynthesis monooxygenase
Xcel_0133	COG4702	Belongs to the UPF0303 family
Xcel_0134	COG0789	Transcriptional regulator
Xcel_0138	COG2201	protein-glutamate methylesterase activity
Xcel_0142	COG0659	secondary active sulfate transmembrane transporter activity
Xcel_0144	COG1309	transcriptional regulator
Xcel_0145	COG1131	(ABC) transporter
Xcel_0155	COG0406	alpha-ribazole phosphatase activity
Xcel_0160	COG0328	RNA-DNA hybrid ribonuclease activity
Xcel_0162	COG3265	gluconokinase activity
Xcel_0166	COG1053	succinate dehydrogenase
Xcel_0172	COG2018	Roadblock/LC7 domain
Xcel_0179	COG1176	ABC-type spermidine putrescine transport system, permease component I
Xcel_0180	COG3842	ATPase activity
Xcel_0183	COG0166	Belongs to the GPI family
Xcel_0186	COG1609	Transcriptional regulator
Xcel_0192	COG0589	response to stress
Xcel_0194	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Xcel_0201	COG0443	Heat shock 70 kDa protein
Xcel_0203	COG0484	heat shock protein binding
Xcel_0204	COG0789	Transcriptional regulator
Xcel_0207	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Xcel_0208	COG0590	tRNA wobble adenosine to inosine editing
Xcel_0210	COG1132	(ABC) transporter
Xcel_0212	COG2197	response regulator
Xcel_0220	COG0438	transferase activity, transferring glycosyl groups
Xcel_0223	COG1960	acyl-CoA dehydrogenase activity
Xcel_0225	COG3201	nicotinamide mononucleotide transporter
Xcel_0226	COG2223	nitrite transmembrane transporter activity
Xcel_0227	COG1309	transcriptional regulator
Xcel_0229	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Xcel_0233	COG2233	PERMEase
Xcel_0239	COG2197	response regulator
Xcel_0240	COG3851	Histidine kinase
Xcel_0244	COG2197	response regulator
Xcel_0250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Xcel_0251	COG2011	ABC-type metal ion transport system permease component
Xcel_0256	COG1940	carbohydrate kinase activity
Xcel_0258	COG1172	Belongs to the binding-protein-dependent transport system permease family
Xcel_0261	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
Xcel_0263	COG0601	transmembrane transport
Xcel_0265	COG0444	Belongs to the ABC transporter superfamily
Xcel_0266	COG4172	Belongs to the ABC transporter superfamily
Xcel_0271	COG0598	Magnesium transport protein CorA
Xcel_0272	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Xcel_0281	COG2329	Antibiotic biosynthesis monooxygenase
Xcel_0285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Xcel_0287	COG1733	regulation of RNA biosynthetic process
Xcel_0292	COG0513	Belongs to the DEAD box helicase family
Xcel_0293	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Xcel_0300	COG0306	phosphate transporter
Xcel_0302	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Xcel_0304	COG0251	oxidation-reduction process
Xcel_0305	COG0179	Fumarylacetoacetate (FAA) hydrolase
Xcel_0306	COG1946	Acyl-CoA thioesterase
Xcel_0310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_0311	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Xcel_0313	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Xcel_0316	COG0456	acetyltransferase
Xcel_0317	COG4804	nuclease activity
Xcel_0318	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Xcel_0319	COG1902	pentaerythritol trinitrate reductase activity
Xcel_0330	COG1205	dead DEAH box helicase
Xcel_0330	COG1111	helicase
Xcel_0333	COG1362	aminopeptidase activity
Xcel_0336	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Xcel_0337	COG2514	catechol 2,3-dioxygenase activity
Xcel_0339	COG2318	DinB family
Xcel_0342	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcel_0344	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Xcel_0344	COG1754	DNA topoisomerase type I activity
Xcel_0345	COG0577	efflux transmembrane transporter activity
Xcel_0345	COG1136	(ABC) transporter
Xcel_0346	COG1136	(ABC) transporter
Xcel_0347	COG1104	cysteine desulfurase activity
Xcel_0349	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Xcel_0350	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Xcel_0358	COG0242	peptide deformylase activity
Xcel_0363	COG0542	response to heat
Xcel_0364	COG0546	phosphoglycolate phosphatase activity
Xcel_0366	COG1609	Transcriptional regulator
Xcel_0367	COG4209	transmembrane transport
Xcel_0368	COG0395	ABC-type sugar transport system, permease component
Xcel_0372	COG1609	Transcriptional regulator
Xcel_0375	COG2186	Transcriptional regulator
Xcel_0377	COG0667	Aldo Keto reductase
Xcel_0380	COG1136	(ABC) transporter
Xcel_0383	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Xcel_0384	COG2354	Protein conserved in bacteria
Xcel_0386	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Xcel_0389	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Xcel_0390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Xcel_0391	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Xcel_0392	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Xcel_0396	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Xcel_0399	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Xcel_0400	COG1609	Transcriptional regulator
Xcel_0402	COG0235	Class ii aldolase
Xcel_0403	COG2160	L-arabinose isomerase activity
Xcel_0404	COG4213	ABC transporter substrate-binding protein
Xcel_0406	COG4214	carbohydrate transport
Xcel_0409	COG1175	transmembrane transport
Xcel_0410	COG0395	ABC-type sugar transport system, permease component
Xcel_0411	COG1653	transport
Xcel_0414	COG1131	(ABC) transporter
Xcel_0419	COG1879	ABC-type sugar transport system periplasmic component
Xcel_0421	COG1172	Belongs to the binding-protein-dependent transport system permease family
Xcel_0422	COG1172	Belongs to the binding-protein-dependent transport system permease family
Xcel_0423	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xcel_0424	COG1116	anion transmembrane transporter activity
Xcel_0428	COG0569	domain protein
Xcel_0429	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Xcel_0430	COG0123	including yeast histone deacetylase and acetoin utilization protein
Xcel_0431	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_0432	COG0667	Aldo Keto reductase
Xcel_0434	COG1116	anion transmembrane transporter activity
Xcel_0435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xcel_0438	COG0560	Phosphoserine phosphatase
Xcel_0440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Xcel_0443	COG0406	alpha-ribazole phosphatase activity
Xcel_0445	COG0785	Cytochrome C biogenesis protein
Xcel_0446	COG1333	cytochrome c biogenesis protein
Xcel_0447	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Xcel_0452	COG1470	cell adhesion involved in biofilm formation
Xcel_0455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Xcel_0457	COG4948	Mandelate Racemase Muconate Lactonizing
Xcel_0458	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Xcel_0459	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Xcel_0460	COG1309	transcriptional regulator
Xcel_0465	COG0534	Mate efflux family protein
Xcel_0466	COG1169	isochorismate synthase
Xcel_0467	COG2226	methyltransferase
Xcel_0468	COG0644	oxidoreductase
Xcel_0470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcel_0471	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcel_0472	COG0649	NAD binding
Xcel_0474	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Xcel_0475	COG1034	ATP synthesis coupled electron transport
Xcel_0476	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Xcel_0477	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Xcel_0478	COG0839	Belongs to the complex I subunit 6 family
Xcel_0479	COG0713	ATP synthesis coupled electron transport
Xcel_0480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xcel_0482	COG1007	ATP synthesis coupled electron transport
Xcel_0485	COG0714	Associated with various cellular activities
Xcel_0493	COG1674	ftsk spoiiie
Xcel_0503	COG0501	Belongs to the peptidase M48B family
Xcel_0505	COG0561	phosphatase activity
Xcel_0506	COG1660	Displays ATPase and GTPase activities
Xcel_0508	COG1666	GTP binding
Xcel_0524	COG3617	BRO family, N-terminal domain
Xcel_0577	COG0305	Participates in initiation and elongation during chromosome replication
Xcel_0598	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Xcel_0599	COG2030	dehydratase
Xcel_0601	COG1609	Transcriptional regulator
Xcel_0602	COG0738	Major facilitator superfamily
Xcel_0603	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Xcel_0605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Xcel_0606	COG2197	response regulator
Xcel_0607	COG4585	Histidine kinase
Xcel_0608	COG0842	Transport permease protein
Xcel_0610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Xcel_0612	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Xcel_0613	COG0081	regulation of translation
Xcel_0618	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Xcel_0619	COG0222	ribosome binding
Xcel_0620	COG0085	RNA polymerase activity
Xcel_0621	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Xcel_0622	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Xcel_0623	COG0049	tRNA binding
Xcel_0624	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Xcel_0625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Xcel_0626	COG0051	transcription antitermination factor activity, RNA binding
Xcel_0627	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Xcel_0628	COG0088	Forms part of the polypeptide exit tunnel
Xcel_0629	COG0089	rRNA binding
Xcel_0630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Xcel_0631	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Xcel_0632	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Xcel_0633	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Xcel_0634	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Xcel_0635	COG0255	Belongs to the universal ribosomal protein uL29 family
Xcel_0636	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Xcel_0637	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Xcel_0638	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Xcel_0639	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Xcel_0640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Xcel_0641	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Xcel_0642	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Xcel_0644	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Xcel_0645	COG1841	ribosomal large subunit assembly
Xcel_0646	COG0200	Binds to the 23S rRNA
Xcel_0647	COG0201	protein transport
Xcel_0648	COG0563	adenylate kinase activity
Xcel_0650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Xcel_0651	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Xcel_0652	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Xcel_0653	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Xcel_0654	COG0202	RNA polymerase activity
Xcel_0655	COG0203	ribosomal protein L17
Xcel_0657	COG1940	carbohydrate kinase activity
Xcel_0658	COG0101	tRNA pseudouridine synthase activity
Xcel_0661	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Xcel_0662	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Xcel_0664	COG0242	peptide deformylase activity
Xcel_0666	COG1072	(Pantothenic acid kinase))
Xcel_0667	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Xcel_0668	COG0736	holo-[acyl-carrier-protein] synthase activity
Xcel_0669	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_0671	COG0386	Belongs to the glutathione peroxidase family
Xcel_0672	COG0564	pseudouridine synthase activity
Xcel_0673	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Xcel_0674	COG0802	atpase or kinase
Xcel_0676	COG0456	acetyltransferase
Xcel_0678	COG0778	Nitroreductase
Xcel_0679	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Xcel_0681	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Xcel_0684	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Xcel_0689	COG0516	GMP reductase activity
Xcel_0690	COG1012	belongs to the aldehyde dehydrogenase family
Xcel_0692	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Xcel_0696	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Xcel_0697	COG1132	(ABC) transporter
Xcel_0698	COG1132	(ABC) transporter
Xcel_0700	COG1136	(ABC) transporter
Xcel_0700	COG0577	efflux transmembrane transporter activity
Xcel_0705	COG0519	Catalyzes the synthesis of GMP from XMP
Xcel_0705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Xcel_0710	COG2197	response regulator
Xcel_0711	COG1648	precorrin-2 dehydrogenase activity
Xcel_0711	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xcel_0712	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xcel_0713	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Xcel_0717	COG0175	sulfate reduction
Xcel_0718	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcel_0719	COG2855	membrane
Xcel_0724	COG2746	aminoglycoside 3-N-acetyltransferase activity
Xcel_0725	COG0542	response to heat
Xcel_0727	COG0045	succinate-CoA ligase (ADP-forming) activity
Xcel_0729	COG1464	Belongs to the NlpA lipoprotein family
Xcel_0732	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Xcel_0733	COG2011	ABC-type metal ion transport system permease component
Xcel_0741	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Xcel_0743	COG0039	L-malate dehydrogenase activity
Xcel_0745	COG0640	Transcriptional regulator
Xcel_0753	COG4214	carbohydrate transport
Xcel_0754	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Xcel_0755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Xcel_0758	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Xcel_0759	COG2197	response regulator
Xcel_0760	COG4585	Histidine kinase
Xcel_0761	COG1131	(ABC) transporter
Xcel_0766	COG2239	Acts as a magnesium transporter
Xcel_0769	COG0006	proline dipeptidase activity
Xcel_0771	COG0613	PHP domain protein
Xcel_0772	COG2095	MarC family integral membrane protein
Xcel_0774	COG0513	Belongs to the DEAD box helicase family
Xcel_0784	COG2816	NAD+ diphosphatase activity
Xcel_0792	COG3480	Lon protease (S16) C-terminal proteolytic domain
Xcel_0793	COG1615	UPF0182 protein
Xcel_0815	COG1136	(ABC) transporter
Xcel_0816	COG1136	(ABC) transporter
Xcel_0816	COG0577	efflux transmembrane transporter activity
Xcel_0822	COG2314	TM2 domain
Xcel_0824	COG0739	heme binding
Xcel_0830	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Xcel_0831	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Xcel_0852	COG1136	(ABC) transporter
Xcel_0877	COG3012	SEC-C Motif Domain Protein
Xcel_0878	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Xcel_0879	COG2720	vancomycin resistance protein
Xcel_0881	COG1129	ABC transporter
Xcel_0882	COG1172	Belongs to the binding-protein-dependent transport system permease family
Xcel_0883	COG1172	Belongs to the binding-protein-dependent transport system permease family
Xcel_0884	COG1879	ABC-type sugar transport system periplasmic component
Xcel_0887	COG3347	Dehydrogenase
Xcel_0887	COG1028	Short-chain dehydrogenase reductase Sdr
Xcel_0888	COG1609	Transcriptional regulator
Xcel_0889	COG1556	Lactate utilization protein
Xcel_0890	COG1139	Iron-sulfur cluster binding protein
Xcel_0891	COG0247	lactate metabolic process
Xcel_0896	COG0673	inositol 2-dehydrogenase activity
Xcel_0898	COG1175	transmembrane transport
Xcel_0899	COG0395	ABC-type sugar transport system, permease component
Xcel_0908	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcel_0913	COG1012	belongs to the aldehyde dehydrogenase family
Xcel_0916	COG1609	Transcriptional regulator
Xcel_0920	COG3250	beta-galactosidase activity
Xcel_0925	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Xcel_0927	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Xcel_0930	COG0601	transmembrane transport
Xcel_0932	COG0444	Belongs to the ABC transporter superfamily
Xcel_0935	COG0114	fumarate hydratase activity
Xcel_0937	COG1722	exodeoxyribonuclease VII activity
Xcel_0939	COG1570	exodeoxyribonuclease VII activity
Xcel_0941	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Xcel_0942	COG1322	Protein conserved in bacteria
Xcel_0946	COG0012	GTP binding
Xcel_0952	COG4166	transmembrane transport
Xcel_0954	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Xcel_0955	COG0444	Belongs to the ABC transporter superfamily
Xcel_0956	COG4608	Belongs to the ABC transporter superfamily
Xcel_0961	COG4172	Belongs to the ABC transporter superfamily
Xcel_0963	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Xcel_0967	COG0077	Prephenate dehydratase
Xcel_0968	COG0287	Prephenate dehydrogenase
Xcel_0976	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xcel_0977	COG1611	Belongs to the LOG family
Xcel_0978	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Xcel_0981	COG1595	DNA-templated transcription, initiation
Xcel_0984	COG0180	Tryptophanyl-tRNA synthetase
Xcel_0987	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Xcel_0988	COG1053	succinate dehydrogenase
Xcel_0990	COG2009	succinate dehydrogenase
Xcel_0992	COG0662	Cupin 2, conserved barrel domain protein
Xcel_0992	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Xcel_0993	COG1473	amidohydrolase
Xcel_0993	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Xcel_0994	COG1744	ABC transporter substrate-binding protein PnrA-like
Xcel_1002	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Xcel_1003	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Xcel_1005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcel_1009	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Xcel_1012	COG4770	biotin carboxylase activity
Xcel_1013	COG0424	maF-like protein
Xcel_1021	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Xcel_1024	COG2135	peptidase activity
Xcel_1025	COG1316	TRANSCRIPTIONal
Xcel_1026	COG1316	TRANSCRIPTIONal
Xcel_1034	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Xcel_1035	COG2884	Cell division ATP-binding protein ftsE
Xcel_1036	COG2177	Part of the ABC transporter FtsEX involved in
Xcel_1038	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Xcel_1040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Xcel_1044	COG1846	Transcriptional regulator
Xcel_1044	COG1940	carbohydrate kinase activity
Xcel_1046	COG1175	transmembrane transport
Xcel_1048	COG1940	carbohydrate kinase activity
Xcel_1049	COG0363	glucosamine-6-phosphate deaminase activity
Xcel_1054	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcel_1056	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Xcel_1058	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Xcel_1059	COG1234	tRNA 3'-trailer cleavage
Xcel_1061	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Xcel_1062	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Xcel_1063	COG0488	(ABC) transporter
Xcel_1065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Xcel_1066	COG2154	pterin-4-alpha-carbinolamine dehydratase
Xcel_1069	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Xcel_1073	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Xcel_1075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Xcel_1079	COG1174	glycine betaine transport
Xcel_1080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Xcel_1083	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Xcel_1086	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Xcel_1091	COG0481	GTPase activity
Xcel_1099	COG1263	PTS System
Xcel_1099	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Xcel_1100	COG0668	transmembrane transport
Xcel_1104	COG3590	peptidase
Xcel_1108	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_1110	COG1045	serine acetyltransferase
Xcel_1118	COG0544	peptidyl-prolyl cis-trans isomerase activity
Xcel_1120	COG0740	serine-type endopeptidase activity
Xcel_1121	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Xcel_1123	COG1605	Chorismate mutase
Xcel_1123	COG0287	Prephenate dehydrogenase
Xcel_1126	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Xcel_1127	COG0765	amino acid transport
Xcel_1128	COG1126	abc transporter atp-binding protein
Xcel_1130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_1131	COG0778	Nitroreductase
Xcel_1131	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Xcel_1135	COG1252	NADH dehydrogenase
Xcel_1136	COG1595	DNA-templated transcription, initiation
Xcel_1140	COG0395	ABC-type sugar transport system, permease component
Xcel_1148	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Xcel_1149	COG0285	dihydrofolate synthase activity
Xcel_1150	COG5297	Belongs to the glycosyl hydrolase family 6
Xcel_1151	COG1609	Transcriptional regulator
Xcel_1153	COG5297	Belongs to the glycosyl hydrolase family 6
Xcel_1153	COG4733	cellulase activity
Xcel_1154	COG2376	Dihydroxyacetone kinase
Xcel_1155	COG1461	Dihydroxyacetone kinase
Xcel_1158	COG0105	UTP biosynthetic process
Xcel_1159	COG1196	nuclear chromosome segregation
Xcel_1164	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Xcel_1167	COG0228	four-way junction DNA binding
Xcel_1168	COG1837	Belongs to the UPF0109 family
Xcel_1169	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Xcel_1170	COG0336	Belongs to the RNA methyltransferase TrmD family
Xcel_1171	COG0335	large ribosomal subunit rRNA binding
Xcel_1172	COG0681	Belongs to the peptidase S26 family
Xcel_1173	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Xcel_1175	COG0792	nuclease activity
Xcel_1176	COG0606	chelatase, subunit chli
Xcel_1178	COG4974	Belongs to the 'phage' integrase family
Xcel_1180	COG0052	Belongs to the universal ribosomal protein uS2 family
Xcel_1181	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Xcel_1183	COG0233	cytoplasmic translational termination
Xcel_1184	COG0575	Belongs to the CDS family
Xcel_1185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Xcel_1194	COG1501	Belongs to the glycosyl hydrolase 31 family
Xcel_1195	COG1472	Belongs to the glycosyl hydrolase 3 family
Xcel_1200	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Xcel_1201	COG0750	zinc metalloprotease
Xcel_1202	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Xcel_1205	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Xcel_1206	COG0442	prolyl-tRNA aminoacylation
Xcel_1208	COG0779	Required for maturation of 30S ribosomal subunits
Xcel_1211	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Xcel_1212	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Xcel_1213	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Xcel_1216	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Xcel_1217	COG1185	polyribonucleotide nucleotidyltransferase activity
Xcel_1218	COG0612	Peptidase, M16
Xcel_1219	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Xcel_1230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Xcel_1234	COG1674	ftsk spoiiie
Xcel_1237	COG1546	Belongs to the CinA family
Xcel_1237	COG1058	Belongs to the CinA family
Xcel_1238	COG1396	sequence-specific DNA binding
Xcel_1239	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Xcel_1240	COG1201	RNA secondary structure unwinding
Xcel_1242	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Xcel_1243	COG2137	regulation of response to DNA damage stimulus
Xcel_1244	COG0765	amino acid transport
Xcel_1245	COG0765	amino acid transport
Xcel_1246	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Xcel_1247	COG1126	abc transporter atp-binding protein
Xcel_1248	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Xcel_1252	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Xcel_1253	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Xcel_1254	COG2813	Specifically methylates the guanine in position
Xcel_1255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Xcel_1258	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Xcel_1259	COG1388	LysM domain
Xcel_1260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Xcel_1261	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Xcel_1264	COG4251	negative regulation of phosphorylation
Xcel_1265	COG0784	Response regulator, receiver
Xcel_1267	COG1278	Cold shock
Xcel_1274	COG0714	Associated with various cellular activities
Xcel_1275	COG2001	Belongs to the MraZ family
Xcel_1276	COG0275	rRNA processing
Xcel_1278	COG0768	penicillin binding
Xcel_1281	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcel_1282	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Xcel_1284	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Xcel_1285	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Xcel_1287	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Xcel_1289	COG1799	cell septum assembly
Xcel_1291	COG3599	regulation of cell shape
Xcel_1292	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Xcel_1293	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Xcel_1296	COG0587	DNA-directed DNA polymerase activity
Xcel_1301	COG2501	S4 domain
Xcel_1302	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Xcel_1303	COG1660	Displays ATPase and GTPase activities
Xcel_1307	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcel_1308	COG0131	Imidazoleglycerol-phosphate dehydratase
Xcel_1310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Xcel_1311	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Xcel_1316	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Xcel_1317	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Xcel_1318	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Xcel_1319	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xcel_1321	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Xcel_1327	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Xcel_1328	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Xcel_1329	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Xcel_1330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Xcel_1332	COG1438	arginine binding
Xcel_1333	COG0165	Argininosuccinate lyase
Xcel_1334	COG0572	uridine kinase
Xcel_1335	COG2094	Belongs to the DNA glycosylase MPG family
Xcel_1336	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Xcel_1338	COG0647	UMP catabolic process
Xcel_1342	COG0497	DNA recombination
Xcel_1347	COG0504	CTP synthase activity
Xcel_1353	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcel_1355	COG1131	(ABC) transporter
Xcel_1358	COG0719	Fe-S assembly protein
Xcel_1360	COG0396	ATPase activity
Xcel_1362	COG0822	iron-sulfur transferase activity
Xcel_1363	COG2151	metal-sulfur cluster biosynthetic enzyme
Xcel_1369	COG3833	ABC-type maltose transport systems, permease component
Xcel_1370	COG1175	transmembrane transport
Xcel_1373	COG0673	inositol 2-dehydrogenase activity
Xcel_1384	COG2267	carboxylic ester hydrolase activity
Xcel_1389	COG1051	belongs to the nudix hydrolase family
Xcel_1393	COG4607	ABC-type enterochelin transport system periplasmic component
Xcel_1394	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_1395	COG4605	iron ion homeostasis
Xcel_1396	COG4604	ABC transporter, ATP-binding protein
Xcel_1398	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Xcel_1399	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcel_1402	COG1028	Short-chain dehydrogenase reductase Sdr
Xcel_1408	COG1695	Transcriptional regulator
Xcel_1411	COG0488	(ABC) transporter
Xcel_1416	COG1028	Short-chain dehydrogenase reductase Sdr
Xcel_1421	COG0297	glycogen (starch) synthase activity
Xcel_1424	COG0745	RESPONSE REGULATOR receiver
Xcel_1425	COG2205	protein histidine kinase activity
Xcel_1427	COG1119	ATPase activity
Xcel_1441	COG0587	DNA-directed DNA polymerase activity
Xcel_1445	COG1988	membrane-bound metal-dependent
Xcel_1447	COG2382	esterase
Xcel_1448	COG1120	ATPase activity
Xcel_1449	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_1450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_1451	COG4592	Periplasmic binding protein
Xcel_1453	COG0351	phosphomethylpyrimidine kinase
Xcel_1453	COG0352	thiamine-phosphate diphosphorylase activity
Xcel_1453	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Xcel_1455	COG0352	thiamine-phosphate diphosphorylase activity
Xcel_1456	COG2022	thiamine diphosphate biosynthetic process
Xcel_1456	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Xcel_1458	COG2022	thiamine diphosphate biosynthetic process
Xcel_1460	COG2197	response regulator
Xcel_1471	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Xcel_1474	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xcel_1477	COG0656	L-ascorbic acid biosynthetic process
Xcel_1479	COG0215	cysteine-tRNA ligase activity
Xcel_1481	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Xcel_1483	COG0517	IMP dehydrogenase activity
Xcel_1483	COG1994	Peptidase M50
Xcel_1485	COG1222	aaa ATPase
Xcel_1486	COG4122	O-methyltransferase activity
Xcel_1488	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Xcel_1489	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Xcel_1490	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Xcel_1492	COG0107	imidazoleglycerol-phosphate synthase activity
Xcel_1493	COG1132	(ABC) transporter
Xcel_1494	COG1132	(ABC) transporter
Xcel_1499	COG0134	indole-3-glycerol-phosphate synthase activity
Xcel_1500	COG0133	tryptophan synthase activity
Xcel_1501	COG0159	tryptophan synthase activity
Xcel_1502	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Xcel_1503	COG0067	glutamate synthase
Xcel_1503	COG0069	glutamate synthase activity
Xcel_1503	COG0070	glutamate synthase
Xcel_1515	COG0539	negative regulation of cytoplasmic translation
Xcel_1516	COG1090	epimerase
Xcel_1517	COG1132	(ABC) transporter
Xcel_1520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Xcel_1520	COG0237	dephospho-CoA kinase activity
Xcel_1529	COG0556	nucleotide-excision repair
Xcel_1533	COG0861	Integral membrane protein TerC family
Xcel_1534	COG0861	Integral membrane protein TerC family
Xcel_1544	COG0322	excinuclease ABC activity
Xcel_1545	COG1660	Displays ATPase and GTPase activities
Xcel_1546	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Xcel_1547	COG1481	regulation of sporulation
Xcel_1548	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Xcel_1549	COG0126	phosphoglycerate kinase activity
Xcel_1550	COG0149	triose-phosphate isomerase activity
Xcel_1551	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Xcel_1553	COG0363	glucosamine-6-phosphate deaminase activity
Xcel_1556	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Xcel_1558	COG0109	protoheme IX farnesyltransferase activity
Xcel_1562	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Xcel_1563	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Xcel_1565	COG1160	GTP binding
Xcel_1579	COG4974	Belongs to the 'phage' integrase family
Xcel_1582	COG1136	(ABC) transporter
Xcel_1604	COG2226	methyltransferase
Xcel_1606	COG3012	SEC-C Motif Domain Protein
Xcel_1616	COG1136	(ABC) transporter
Xcel_1616	COG0577	efflux transmembrane transporter activity
Xcel_1617	COG4585	Histidine kinase
Xcel_1618	COG2197	response regulator
Xcel_1619	COG2197	response regulator
Xcel_1620	COG4585	Histidine kinase
Xcel_1624	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcel_1625	COG2146	nitrite reductase [NAD(P)H] activity
Xcel_1625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcel_1626	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Xcel_1626	COG1648	precorrin-2 dehydrogenase activity
Xcel_1632	COG1309	transcriptional regulator
Xcel_1633	COG2197	response regulator
Xcel_1634	COG4585	Histidine kinase
Xcel_1645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Xcel_1646	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Xcel_1648	COG0673	inositol 2-dehydrogenase activity
Xcel_1650	COG2318	DinB family
Xcel_1656	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Xcel_1659	COG1560	Kdo2-lipid A biosynthetic process
Xcel_1660	COG0438	transferase activity, transferring glycosyl groups
Xcel_1662	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Xcel_1663	COG1051	belongs to the nudix hydrolase family
Xcel_1664	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Xcel_1665	COG0217	transcriptional regulatory protein
Xcel_1666	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Xcel_1667	COG0632	four-way junction helicase activity
Xcel_1668	COG2255	four-way junction helicase activity
Xcel_1670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Xcel_1671	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Xcel_1672	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Xcel_1673	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Xcel_1674	COG1793	dna ligase
Xcel_1677	COG1196	nuclear chromosome segregation
Xcel_1679	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Xcel_1680	COG0124	histidyl-tRNA synthetase
Xcel_1682	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Xcel_1686	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Xcel_1689	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Xcel_1690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Xcel_1694	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Xcel_1695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Xcel_1696	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Xcel_1696	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Xcel_1702	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Xcel_1705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Xcel_1706	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Xcel_1707	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Xcel_1708	COG0540	Belongs to the ATCase OTCase family
Xcel_1709	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Xcel_1712	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Xcel_1713	COG0284	orotidine-5'-phosphate decarboxylase activity
Xcel_1714	COG0322	excinuclease ABC activity
Xcel_1716	COG1758	RNA polymerase activity
Xcel_1718	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Xcel_1722	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Xcel_1725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Xcel_1728	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Xcel_1728	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Xcel_1729	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Xcel_1730	COG0140	phosphoribosyl-ATP diphosphatase activity
Xcel_1731	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Xcel_1738	COG1716	ATPase activity
Xcel_1742	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Xcel_1748	COG3340	Belongs to the peptidase S51 family
Xcel_1750	COG2337	Toxic component of a toxin-antitoxin (TA) module
Xcel_1756	COG3550	peptidyl-serine autophosphorylation
Xcel_1765	COG1487	ribonuclease activity
Xcel_1767	COG0137	argininosuccinate synthase activity
Xcel_1771	COG0686	Belongs to the AlaDH PNT family
Xcel_1773	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_1775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Xcel_1776	COG1228	amidohydrolase
Xcel_1778	COG1597	lipid kinase activity
Xcel_1779	COG0805	protein transport
Xcel_1783	COG2378	regulation of single-species biofilm formation
Xcel_1787	COG0714	Associated with various cellular activities
Xcel_1791	COG0783	Belongs to the Dps family
Xcel_1793	COG1739	Uncharacterized protein family UPF0029
Xcel_1795	COG0009	L-threonylcarbamoyladenylate synthase
Xcel_1805	COG1132	(ABC) transporter
Xcel_1806	COG1132	(ABC) transporter
Xcel_1814	COG2146	nitrite reductase [NAD(P)H] activity
Xcel_1814	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcel_1815	COG2146	nitrite reductase [NAD(P)H] activity
Xcel_1815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcel_1818	COG0315	cyclic pyranopterin monophosphate synthase activity
Xcel_1820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Xcel_1821	COG0243	molybdopterin cofactor binding
Xcel_1822	COG2223	nitrite transmembrane transporter activity
Xcel_1825	COG1140	nitrate reductase beta subunit
Xcel_1839	COG0475	glutathione-regulated potassium exporter activity
Xcel_1840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Xcel_1841	COG1006	Multisubunit Na H antiporter MnhC subunit
Xcel_1847	COG4608	Belongs to the ABC transporter superfamily
Xcel_1848	COG0444	Belongs to the ABC transporter superfamily
Xcel_1849	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Xcel_1850	COG0601	transmembrane transport
Xcel_1851	COG4166	transmembrane transport
Xcel_1854	COG1131	(ABC) transporter
Xcel_1856	COG1022	Amp-dependent synthetase and ligase
Xcel_1858	COG1253	flavin adenine dinucleotide binding
Xcel_1861	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Xcel_1862	COG2116	formate transmembrane transporter activity
Xcel_1863	COG4269	membrane
Xcel_1865	COG0640	Transcriptional regulator
Xcel_1882	COG2326	polyphosphate kinase activity
Xcel_1883	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Xcel_1889	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Xcel_1891	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Xcel_1892	COG0183	Belongs to the thiolase family
Xcel_1893	COG1250	3-hydroxyacyl-CoA dehydrogenase
Xcel_1893	COG1024	Enoyl-CoA hydratase
Xcel_1894	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Xcel_1896	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Xcel_1900	COG3973	AAA domain
Xcel_1901	COG0494	nUDIX hydrolase
Xcel_1903	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Xcel_1906	COG1131	(ABC) transporter
Xcel_1909	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Xcel_1916	COG0531	amino acid
Xcel_1917	COG0569	domain protein
Xcel_1922	COG0756	dUTP diphosphatase activity
Xcel_1926	COG2860	membrane
Xcel_1929	COG1435	thymidine kinase activity
Xcel_1934	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Xcel_1940	COG0646	methionine synthase
Xcel_1940	COG1410	methionine synthase
Xcel_1968	COG1132	(ABC) transporter
Xcel_1969	COG0446	pyridine nucleotide-disulphide oxidoreductase
Xcel_1970	COG1937	Protein conserved in bacteria
Xcel_1973	COG0318	PFAM AMP-dependent synthetase and ligase
Xcel_1979	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Xcel_1982	COG3655	Transcriptional regulator
Xcel_1984	COG4941	Belongs to the sigma-70 factor family
Xcel_1988	COG0187	DNA topoisomerase II activity
Xcel_1991	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Xcel_1992	COG0589	response to stress
Xcel_1995	COG0142	geranyltranstransferase activity
Xcel_1997	COG0515	serine threonine protein kinase
Xcel_1997	COG2815	serine threonine protein kinase
Xcel_1998	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Xcel_2002	COG1940	carbohydrate kinase activity
Xcel_2006	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Xcel_2008	COG1845	cytochrome c oxidase, subunit III
Xcel_2009	COG2010	Cytochrome c
Xcel_2010	COG0723	plastoquinol--plastocyanin reductase activity
Xcel_2011	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Xcel_2015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Xcel_2016	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Xcel_2021	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Xcel_2023	COG0667	Aldo Keto reductase
Xcel_2026	COG0167	dihydroorotate dehydrogenase activity
Xcel_2029	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Xcel_2030	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcel_2033	COG0673	inositol 2-dehydrogenase activity
Xcel_2034	COG0321	lipoyl(octanoyl) transferase activity
Xcel_2035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Xcel_2042	COG0596	Alpha beta hydrolase
Xcel_2043	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Xcel_2046	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Xcel_2047	COG0174	glutamine synthetase
Xcel_2051	COG0530	calcium, potassium:sodium antiporter activity
Xcel_2082	COG3022	response to hydroperoxide
Xcel_2083	COG0406	alpha-ribazole phosphatase activity
Xcel_2083	COG0328	RNA-DNA hybrid ribonuclease activity
Xcel_2085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Xcel_2086	COG0659	secondary active sulfate transmembrane transporter activity
Xcel_2090	COG0514	ATP-dependent DNA helicase (RecQ)
Xcel_2094	COG0442	prolyl-tRNA aminoacylation
Xcel_2098	COG0022	dehydrogenase e1 component
Xcel_2099	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcel_2100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Xcel_2102	COG1960	acyl-CoA dehydrogenase activity
Xcel_2105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Xcel_2111	COG0477	Major facilitator Superfamily
Xcel_2119	COG0366	Alpha amylase catalytic
Xcel_2121	COG1940	carbohydrate kinase activity
Xcel_2122	COG2188	Transcriptional regulator
Xcel_2123	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Xcel_2129	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Xcel_2129	COG1199	ATP-dependent helicase activity
Xcel_2132	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Xcel_2136	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Xcel_2137	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Xcel_2138	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Xcel_2148	COG1522	sequence-specific DNA binding
Xcel_2150	COG2814	Major facilitator Superfamily
Xcel_2152	COG2182	Extracellular solute-binding protein
Xcel_2153	COG1175	transmembrane transport
Xcel_2154	COG3833	ABC-type maltose transport systems, permease component
Xcel_2158	COG0366	Alpha amylase catalytic
Xcel_2159	COG0366	Alpha amylase catalytic
Xcel_2160	COG3833	ABC-type maltose transport systems, permease component
Xcel_2161	COG1175	transmembrane transport
Xcel_2164	COG0366	Alpha amylase catalytic
Xcel_2167	COG0423	glycine-tRNA ligase activity
Xcel_2168	COG3443	Belongs to the bacterial solute-binding protein 9 family
Xcel_2168	COG0803	Belongs to the bacterial solute-binding protein 9 family
Xcel_2169	COG1121	(ABC) transporter
Xcel_2170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Xcel_2172	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_2173	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_2174	COG1120	ATPase activity
Xcel_2176	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Xcel_2177	COG1381	Involved in DNA repair and RecF pathway recombination
Xcel_2178	COG0740	serine-type endopeptidase activity
Xcel_2179	COG0740	serine-type endopeptidase activity
Xcel_2180	COG1396	sequence-specific DNA binding
Xcel_2182	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Xcel_2185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Xcel_2187	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Xcel_2189	COG0537	adenosine 5'-monophosphoramidase activity
Xcel_2191	COG0484	heat shock protein binding
Xcel_2192	COG1420	regulation of RNA biosynthetic process
Xcel_2194	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Xcel_2194	COG1672	PFAM Archaeal ATPase
Xcel_2200	COG0481	GTPase activity
Xcel_2203	COG1305	Transglutaminase-like
Xcel_2207	COG0268	Binds directly to 16S ribosomal RNA
Xcel_2216	COG1307	EDD domain protein, DegV family
Xcel_2217	COG0433	COG0433 Predicted ATPase
Xcel_2218	COG4552	Acetyltransferase involved in intracellular survival and related
Xcel_2219	COG0058	SHG alpha-glucan phosphorylase activity
Xcel_2225	COG2814	Major facilitator Superfamily
Xcel_2229	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Xcel_2232	COG2357	RelA SpoT domain protein
Xcel_2234	COG4941	Belongs to the sigma-70 factor family
Xcel_2235	COG3795	YCII-related domain
Xcel_2241	COG0579	oxidoreductase
Xcel_2242	COG0583	DNA-binding transcription factor activity
Xcel_2245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Xcel_2246	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Xcel_2249	COG0588	phosphoglycerate mutase activity
Xcel_2250	COG0799	negative regulation of ribosome biogenesis
Xcel_2252	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Xcel_2254	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Xcel_2255	COG0477	Major facilitator Superfamily
Xcel_2256	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Xcel_2258	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Xcel_2259	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Xcel_2260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Xcel_2261	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Xcel_2263	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Xcel_2265	COG1435	thymidine kinase activity
Xcel_2266	COG1530	ribonuclease E activity
Xcel_2267	COG1271	oxidase subunit
Xcel_2268	COG1294	oxidase, subunit
Xcel_2269	COG4988	ABC transporter
Xcel_2270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Xcel_2272	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Xcel_2273	COG0571	ribonuclease III activity
Xcel_2274	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Xcel_2278	COG0742	ribosomal rna small subunit methyltransferase
Xcel_2280	COG1461	Dihydroxyacetone kinase
Xcel_2281	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Xcel_2285	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xcel_2287	COG0009	L-threonylcarbamoyladenylate synthase
Xcel_2288	COG2271	Major facilitator Superfamily
Xcel_2289	COG4977	sequence-specific DNA binding
Xcel_2292	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Xcel_2294	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Xcel_2295	COG0477	Major facilitator Superfamily
Xcel_2296	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Xcel_2299	COG0602	queuosine metabolic process
Xcel_2300	COG1328	CTP reductase activity
Xcel_2302	COG2149	membrane
Xcel_2306	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_2307	COG1120	ATPase activity
Xcel_2311	COG1733	regulation of RNA biosynthetic process
Xcel_2312	COG2337	Toxic component of a toxin-antitoxin (TA) module
Xcel_2324	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Xcel_2325	COG0210	DNA helicase
Xcel_2340	COG1619	proteins homologs of microcin C7 resistance protein MccF
Xcel_2353	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_2355	COG2186	Transcriptional regulator
Xcel_2356	COG0066	3-isopropylmalate dehydratase activity
Xcel_2357	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Xcel_2358	COG1414	Transcriptional regulator
Xcel_2363	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Xcel_2366	COG0179	Fumarylacetoacetate (FAA) hydrolase
Xcel_2376	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Xcel_2377	COG3304	Inner membrane component domain
Xcel_2381	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Xcel_2382	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Xcel_2383	COG0473	3-isopropylmalate dehydrogenase activity
Xcel_2384	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Xcel_2385	COG0440	acetolactate synthase activity
Xcel_2387	COG2154	pterin-4-alpha-carbinolamine dehydratase
Xcel_2389	COG0129	dihydroxy-acid dehydratase activity
Xcel_2390	COG0129	dihydroxy-acid dehydratase activity
Xcel_2392	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Xcel_2393	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Xcel_2394	COG0154	amidase activity
Xcel_2395	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Xcel_2399	COG1879	ABC-type sugar transport system periplasmic component
Xcel_2400	COG1172	Belongs to the binding-protein-dependent transport system permease family
Xcel_2401	COG1129	ABC transporter
Xcel_2402	COG1940	carbohydrate kinase activity
Xcel_2404	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Xcel_2405	COG1454	alcohol dehydrogenase
Xcel_2405	COG1012	belongs to the aldehyde dehydrogenase family
Xcel_2406	COG1505	serine-type exopeptidase activity
Xcel_2408	COG0482	sulfurtransferase activity
Xcel_2411	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Xcel_2417	COG0366	Alpha amylase catalytic
Xcel_2419	COG3281	Trehalose synthase
Xcel_2420	COG2252	PERMEase
Xcel_2421	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Xcel_2426	COG2267	carboxylic ester hydrolase activity
Xcel_2432	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcel_2432	COG0574	Belongs to the PEP-utilizing enzyme family
Xcel_2436	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xcel_2437	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Xcel_2438	COG1780	Probably involved in ribonucleotide reductase function
Xcel_2442	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Xcel_2445	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Xcel_2447	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Xcel_2448	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Xcel_2449	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Xcel_2450	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Xcel_2451	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Xcel_2452	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Xcel_2454	COG0356	it plays a direct role in the translocation of protons across the membrane
Xcel_2456	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Xcel_2458	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcel_2459	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Xcel_2460	COG0254	rRNA binding
Xcel_2461	COG0438	transferase activity, transferring glycosyl groups
Xcel_2463	COG0083	homoserine kinase activity
Xcel_2464	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Xcel_2465	COG0460	homoserine dehydrogenase
Xcel_2467	COG0018	arginyl-trna synthetase
Xcel_2478	COG2079	MmgE PrpD family protein
Xcel_2479	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Xcel_2484	COG1253	flavin adenine dinucleotide binding
Xcel_2485	COG0745	RESPONSE REGULATOR receiver
Xcel_2486	COG2205	protein histidine kinase activity
Xcel_2487	COG0567	Dehydrogenase, E1 component
Xcel_2487	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcel_2488	COG0667	Aldo Keto reductase
Xcel_2489	COG2017	converts alpha-aldose to the beta-anomer
Xcel_2491	COG5662	AntiSigma factor
Xcel_2492	COG1595	DNA-templated transcription, initiation
Xcel_2494	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Xcel_2496	COG0483	inositol monophosphate 1-phosphatase activity
Xcel_2498	COG2211	Major facilitator Superfamily
Xcel_2505	COG0653	protein targeting
Xcel_2506	COG3214	Protein conserved in bacteria
Xcel_2507	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Xcel_2510	COG0577	efflux transmembrane transporter activity
Xcel_2510	COG1136	(ABC) transporter
Xcel_2512	COG5401	PFAM Sporulation and spore germination
Xcel_2513	COG5002	protein histidine kinase activity
Xcel_2514	COG0745	RESPONSE REGULATOR receiver
Xcel_2518	COG0714	Associated with various cellular activities
Xcel_2526	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Xcel_2530	COG4176	ABC-type proline glycine betaine transport system permease component
Xcel_2533	COG2721	sulfolactate sulfo-lyase activity
Xcel_2535	COG1175	transmembrane transport
Xcel_2536	COG0395	ABC-type sugar transport system, permease component
Xcel_2538	COG1028	Short-chain dehydrogenase reductase Sdr
Xcel_2539	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Xcel_2540	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Xcel_2541	COG2835	tetraacyldisaccharide 4'-kinase activity
Xcel_2542	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Xcel_2543	COG1482	cell wall glycoprotein biosynthetic process
Xcel_2557	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Xcel_2560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Xcel_2563	COG1088	dTDP-glucose 4,6-dehydratase activity
Xcel_2568	COG1216	Glycosyl transferase, family 2
Xcel_2574	COG1216	Glycosyl transferase, family 2
Xcel_2582	COG1215	transferase activity, transferring glycosyl groups
Xcel_2583	COG0463	Glycosyl transferase, family 2
Xcel_2584	COG1216	Glycosyl transferase, family 2
Xcel_2585	COG1215	transferase activity, transferring glycosyl groups
Xcel_2586	COG1134	teichoic acid transport
Xcel_2589	COG3475	LICD family
Xcel_2590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Xcel_2591	COG0438	transferase activity, transferring glycosyl groups
Xcel_2594	COG1316	TRANSCRIPTIONal
Xcel_2595	COG1316	TRANSCRIPTIONal
Xcel_2596	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Xcel_2598	COG2205	protein histidine kinase activity
Xcel_2599	COG0745	RESPONSE REGULATOR receiver
Xcel_2601	COG2197	response regulator
Xcel_2603	COG1136	(ABC) transporter
Xcel_2603	COG0577	efflux transmembrane transporter activity
Xcel_2612	COG1175	transmembrane transport
Xcel_2613	COG0395	ABC-type sugar transport system, permease component
Xcel_2616	COG3459	Glycosyltransferase 36 associated
Xcel_2617	COG1012	belongs to the aldehyde dehydrogenase family
Xcel_2621	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Xcel_2622	COG2890	protein-(glutamine-N5) methyltransferase activity
Xcel_2626	COG1929	Belongs to the glycerate kinase type-1 family
Xcel_2627	COG2409	Drug exporters of the RND superfamily
Xcel_2629	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Xcel_2631	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Xcel_2633	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Xcel_2635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Xcel_2636	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Xcel_2640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Xcel_2642	COG1793	dna ligase
Xcel_2646	COG2813	Specifically methylates the guanine in position
Xcel_2648	COG1175	transmembrane transport
Xcel_2649	COG0395	ABC-type sugar transport system, permease component
Xcel_2650	COG1904	glucuronate isomerase
Xcel_2655	COG1070	Carbohydrate kinase
Xcel_2656	COG0246	Mannitol dehydrogenase
Xcel_2657	COG0673	inositol 2-dehydrogenase activity
Xcel_2659	COG1609	Transcriptional regulator
Xcel_2660	COG4209	transmembrane transport
Xcel_2661	COG0395	ABC-type sugar transport system, permease component
Xcel_2666	COG0246	Mannitol dehydrogenase
Xcel_2667	COG1312	Catalyzes the dehydration of D-mannonate
Xcel_2670	COG3387	PFAM Glycoside hydrolase 15-related
Xcel_2675	COG2814	Major facilitator Superfamily
Xcel_2676	COG1252	NADH dehydrogenase
Xcel_2682	COG0148	phosphopyruvate hydratase activity
Xcel_2692	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Xcel_2700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Xcel_2701	COG0673	inositol 2-dehydrogenase activity
Xcel_2704	COG0193	aminoacyl-tRNA hydrolase activity
Xcel_2705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Xcel_2707	COG0463	Glycosyl transferase, family 2
Xcel_2709	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Xcel_2710	COG1309	transcriptional regulator
Xcel_2711	COG4152	abc transporter atp-binding protein
Xcel_2712	COG1668	transmembrane transport
Xcel_2713	COG1846	Transcriptional regulator
Xcel_2714	COG2807	transmembrane transport
Xcel_2716	COG4585	Histidine kinase
Xcel_2717	COG2197	response regulator
Xcel_2722	COG0488	(ABC) transporter
Xcel_2723	COG3458	cephalosporin-C deacetylase activity
Xcel_2724	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Xcel_2725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Xcel_2730	COG0084	hydrolase, TatD family'
Xcel_2731	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Xcel_2734	COG1335	isochorismatase
Xcel_2741	COG1280	lysine exporter protein (LysE YggA)
Xcel_2750	COG1176	ABC-type spermidine putrescine transport system, permease component I
Xcel_2751	COG3842	ATPase activity
Xcel_2753	COG1609	Transcriptional regulator
Xcel_2755	COG1175	transmembrane transport
Xcel_2760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Xcel_2761	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Xcel_2766	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Xcel_2767	COG1105	Belongs to the carbohydrate kinase PfkB family
Xcel_2768	COG0723	plastoquinol--plastocyanin reductase activity
Xcel_2776	COG1752	Esterase of the alpha-beta hydrolase superfamily
Xcel_2780	COG2207	Transcriptional regulator
Xcel_2780	COG3708	Transcriptional regulator
Xcel_2783	COG1609	Transcriptional regulator
Xcel_2785	COG4209	transmembrane transport
Xcel_2786	COG0395	ABC-type sugar transport system, permease component
Xcel_2793	COG1253	flavin adenine dinucleotide binding
Xcel_2798	COG0366	Alpha amylase catalytic
Xcel_2799	COG1609	Transcriptional regulator
Xcel_2803	COG1136	(ABC) transporter
Xcel_2803	COG4591	ABC-type transport system involved in lipoprotein release permease component
Xcel_2804	COG0577	efflux transmembrane transporter activity
Xcel_2804	COG1136	(ABC) transporter
Xcel_2813	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Xcel_2817	COG1970	mechanosensitive ion channel activity
Xcel_2821	COG3173	Aminoglycoside phosphotransferase
Xcel_2822	COG0577	efflux transmembrane transporter activity
Xcel_2822	COG1136	(ABC) transporter
Xcel_2827	COG2115	Belongs to the xylose isomerase family
Xcel_2828	COG1070	Carbohydrate kinase
Xcel_2841	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xcel_2846	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Xcel_2847	COG2814	Major facilitator Superfamily
Xcel_2848	COG2814	Major facilitator Superfamily
Xcel_2849	COG1846	Transcriptional regulator
Xcel_2856	COG2208	phosphoserine phosphatase activity
Xcel_2856	COG2770	Histidine kinase
Xcel_2867	COG0028	Belongs to the TPP enzyme family
Xcel_2887	COG0489	protein tyrosine kinase activity
Xcel_2900	COG1216	Glycosyl transferase, family 2
Xcel_2903	COG0438	transferase activity, transferring glycosyl groups
Xcel_2906	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Xcel_2911	COG1609	Transcriptional regulator
Xcel_2919	COG1487	ribonuclease activity
Xcel_2925	COG2252	PERMEase
Xcel_2926	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Xcel_2930	COG1278	Cold shock
Xcel_2932	COG1061	Type III restriction enzyme res subunit
Xcel_2934	COG1842	Phage shock protein A
Xcel_2937	COG0745	RESPONSE REGULATOR receiver
Xcel_2938	COG2205	protein histidine kinase activity
Xcel_2941	COG0459	protein refolding
Xcel_2944	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Xcel_2949	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Xcel_2950	COG3842	ATPase activity
Xcel_2952	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Xcel_2953	COG0215	cysteine-tRNA ligase activity
Xcel_2957	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Xcel_2958	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Xcel_2959	COG1329	Transcriptional regulator
Xcel_2961	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Xcel_2965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Xcel_2969	COG0745	RESPONSE REGULATOR receiver
Xcel_2970	COG5002	protein histidine kinase activity
Xcel_2971	COG0704	Plays a role in the regulation of phosphate uptake
Xcel_2972	COG0588	phosphoglycerate mutase activity
Xcel_2973	COG0297	glycogen (starch) synthase activity
Xcel_2977	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Xcel_2984	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Xcel_2985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Xcel_2986	COG0302	gtp cyclohydrolase
Xcel_2987	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Xcel_2989	COG0037	tRNA processing
Xcel_2991	COG2205	protein histidine kinase activity
Xcel_2992	COG0745	RESPONSE REGULATOR receiver
Xcel_2993	COG1840	ABC-type Fe3 transport system, periplasmic component
Xcel_2995	COG3842	ATPase activity
Xcel_2997	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Xcel_2998	COG1063	alcohol dehydrogenase
Xcel_2999	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Xcel_3000	COG3883	PFAM NLP P60 protein
Xcel_3000	COG0791	NLP P60 protein
Xcel_3002	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Xcel_3005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xcel_3014	COG0778	Nitroreductase
Xcel_3016	COG0277	FAD linked oxidase domain protein
Xcel_3016	COG0247	lactate metabolic process
Xcel_3022	COG1490	D-aminoacyl-tRNA deacylase activity
Xcel_3027	COG4129	membrane
Xcel_3028	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Xcel_3029	COG3485	protocatechuate 3,4-dioxygenase
Xcel_3035	COG0745	RESPONSE REGULATOR receiver
Xcel_3036	COG0596	Alpha beta hydrolase
Xcel_3042	COG1408	metallophosphoesterase
Xcel_3056	COG1120	ATPase activity
Xcel_3057	COG0577	efflux transmembrane transporter activity
Xcel_3057	COG1136	(ABC) transporter
Xcel_3058	COG0577	efflux transmembrane transporter activity
Xcel_3058	COG1136	(ABC) transporter
Xcel_3062	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Xcel_3071	COG1268	BioY protein
Xcel_3073	COG0183	Belongs to the thiolase family
Xcel_3074	COG1122	ATPase activity
Xcel_3078	COG0494	nUDIX hydrolase
Xcel_3080	COG0584	glycerophosphoryl diester phosphodiesterase
Xcel_3082	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Xcel_3088	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Xcel_3091	COG0737	Belongs to the 5'-nucleotidase family
Xcel_3094	COG2116	formate transmembrane transporter activity
Xcel_3098	COG0778	Nitroreductase
Xcel_3100	COG2838	Isocitrate dehydrogenase
Xcel_3103	COG1216	Glycosyl transferase, family 2
Xcel_3104	COG2244	polysaccharide biosynthetic process
Xcel_3107	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Xcel_3118	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Xcel_3126	COG0047	phosphoribosylformylglycinamidine synthase activity
Xcel_3127	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Xcel_3133	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Xcel_3134	COG0151	Belongs to the GarS family
Xcel_3138	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Xcel_3144	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Xcel_3147	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Xcel_3148	COG4221	oxidoreductase activity
Xcel_3151	COG0601	transmembrane transport
Xcel_3154	COG1028	Short-chain dehydrogenase reductase Sdr
Xcel_3155	COG0708	Exodeoxyribonuclease III
Xcel_3156	COG1136	(ABC) transporter
Xcel_3156	COG0577	efflux transmembrane transporter activity
Xcel_3157	COG0577	efflux transmembrane transporter activity
Xcel_3157	COG1136	(ABC) transporter
Xcel_3167	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Xcel_3168	COG0601	transmembrane transport
Xcel_3179	COG2197	response regulator
Xcel_3181	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Xcel_3181	COG2169	Transcriptional regulator
Xcel_3186	COG1006	Multisubunit Na H antiporter MnhC subunit
Xcel_3187	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Xcel_3187	COG2111	Na H antiporter
Xcel_3189	COG0717	Belongs to the dCTP deaminase family
Xcel_3195	COG1309	transcriptional regulator
Xcel_3197	COG2909	trisaccharide binding
Xcel_3200	COG1082	Xylose isomerase domain protein TIM barrel
Xcel_3201	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Xcel_3202	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcel_3203	COG2190	(PTS) system
Xcel_3205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Xcel_3206	COG0574	Belongs to the PEP-utilizing enzyme family
Xcel_3206	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Xcel_3214	COG0656	L-ascorbic acid biosynthetic process
Xcel_3218	COG2409	Drug exporters of the RND superfamily
Xcel_3220	COG3336	cytochrome c oxidase
Xcel_3221	COG0508	dehydrogenase complex catalyzes the overall conversion of
Xcel_3222	COG0022	dehydrogenase e1 component
Xcel_3224	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Xcel_3225	COG1950	PFAM Membrane protein of
Xcel_3228	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Xcel_3232	COG5006	permease, DMT superfamily
Xcel_3233	COG0248	Ppx GppA phosphatase
Xcel_3235	COG0395	ABC-type sugar transport system, permease component
Xcel_3236	COG1175	transmembrane transport
Xcel_3237	COG1653	transport
Xcel_3240	COG1396	sequence-specific DNA binding
Xcel_3241	COG0561	phosphatase activity
Xcel_3242	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Xcel_3243	COG1597	lipid kinase activity
Xcel_3245	COG1215	transferase activity, transferring glycosyl groups
Xcel_3247	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Xcel_3248	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Xcel_3249	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Xcel_3251	COG3177	Filamentation induced by cAMP protein fic
Xcel_3252	COG0181	hydroxymethylbilane synthase activity
Xcel_3254	COG0113	porphobilinogen synthase activity
Xcel_3255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Xcel_3257	COG1937	Protein conserved in bacteria
Xcel_3263	COG0601	transmembrane transport
Xcel_3266	COG3657	addiction module killer protein
Xcel_3267	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Xcel_3277	COG1672	PFAM Archaeal ATPase
Xcel_3277	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Xcel_3280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Xcel_3281	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Xcel_3282	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Xcel_3285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Xcel_3286	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Xcel_3289	COG2353	YceI-like domain
Xcel_3293	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Xcel_3296	COG2318	DinB family
Xcel_3304	COG1834	amidinotransferase
Xcel_3312	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Xcel_3316	COG2239	Acts as a magnesium transporter
Xcel_3320	COG1131	(ABC) transporter
Xcel_3322	COG3845	ABC transporter
Xcel_3326	COG2197	response regulator
Xcel_3328	COG3744	PilT protein domain protein
Xcel_3335	COG1733	regulation of RNA biosynthetic process
Xcel_3337	COG1619	proteins homologs of microcin C7 resistance protein MccF
Xcel_3339	COG0596	Alpha beta hydrolase
Xcel_3341	COG0477	Major facilitator Superfamily
Xcel_3345	COG0446	pyridine nucleotide-disulphide oxidoreductase
Xcel_3346	COG2226	methyltransferase
Xcel_3347	COG0640	Transcriptional regulator
Xcel_3350	COG0305	Participates in initiation and elongation during chromosome replication
Xcel_3351	COG0534	Mate efflux family protein
Xcel_3352	COG0359	binds to the 23S rRNA
Xcel_3353	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Xcel_3355	COG0360	Binds together with S18 to 16S ribosomal RNA
Xcel_3356	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcel_3357	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Xcel_3358	COG1695	Transcriptional regulator
Xcel_3359	COG1260	myo-inositol-1-phosphate synthase
Xcel_3361	COG2814	Major facilitator Superfamily
Xcel_3362	COG0617	tRNA 3'-terminal CCA addition
Xcel_3370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Xcel_3371	COG1181	Belongs to the D-alanine--D-alanine ligase family
Xcel_3373	COG1192	Involved in chromosome partitioning
Xcel_3374	COG0357	Ribosomal RNA small subunit methyltransferase G
Xcel_3376	COG0706	membrane insertase activity
Xcel_3377	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Xcel_3378	COG0594	ribonuclease P activity
Xcel_3379	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Xcel_3393	COG0175	sulfate reduction
Xcel_3415	COG1192	Involved in chromosome partitioning
Xcel_3419	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Xcel_3442	COG0791	NLP P60 protein
Xcel_3442	COG3883	PFAM NLP P60 protein
Xcel_3472	COG0194	GDP metabolic process
Xcel_3478	COG2135	peptidase activity