locus-tag	class	description
XFC3_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
XFC3_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
XFC3_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
XFC3_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFC3_00035	ENOG4108K0D	peptidase, M48
XFC3_00075	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
XFC3_00095	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
XFC3_00110	ENOG4108ZUW	Major pilin subunit
XFC3_00140	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
XFC3_00145	ENOG4105CGF	Aromatic amino acid aminotransferase
XFC3_00175	ENOG4105D6S	protein involved in catabolism of external DNA
XFC3_00185	ENOG4108JA2	transcriptioN-repair coupling factor
XFC3_00195	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
XFC3_00200	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
XFC3_00205	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
XFC3_00210	ENOG4105C4R	Atp-dependent dna helicase
XFC3_00220	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
XFC3_00235	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
XFC3_00245	ENOG4105MJ2	Competence protein
XFC3_00250	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
XFC3_00255	ENOG4105D78	K07001 NTE family protein
XFC3_00260	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
XFC3_00295	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
XFC3_00305	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFC3_00335	ENOG4108VEV	chaperone
XFC3_00340	ENOG4105X0I	Fimbrial
XFC3_00345	ENOG4107TH8	cina domain protein
XFC3_00350	ENOG4105CSH	Transporter
XFC3_00355	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
XFC3_00360	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
XFC3_00365	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
XFC3_00370	ENOG4105EEI	dihydropteroate synthase
XFC3_00380	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
XFC3_00385	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
XFC3_00390	ENOG4105HBR	Rna-binding protein
XFC3_00400	ENOG4105C01	Dihydroxy-acid dehydratase
XFC3_00425	ENOG4105D1S	lipid A biosynthesis
XFC3_00430	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
XFC3_00440	ENOG4105K5M	30s ribosomal protein S16
XFC3_00445	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
XFC3_00450	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
XFC3_00455	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
XFC3_00460	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
XFC3_00465	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
XFC3_00470	ENOG4105KUZ	arsenate reductase
XFC3_00475	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
XFC3_00480	ENOG4105CAQ	asparagine synthetase
XFC3_00490	ENOG4105EA8	2-Nitropropane dioxygenase
XFC3_00495	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
XFC3_00500	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
XFC3_00520	ENOG4105DGW	oligopeptidase A
XFC3_00535	ENOG4105E3B	Multicopper oxidase
XFC3_00545	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
XFC3_00585	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
XFC3_00595	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
XFC3_00600	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
XFC3_00615	ENOG4105C75	arginyL-tRNA synthetase
XFC3_00620	ENOG4105W5Q	DNA repair protein (RadC
XFC3_00625	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
XFC3_00635	ENOG4107QKV	phosphomannomutase
XFC3_00645	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
XFC3_00680	ENOG4105EYM	Major Facilitator superfamily
XFC3_00685	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
XFC3_00690	ENOG4105DR5	peptidase
XFC3_00695	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
XFC3_00725	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
XFC3_00740	ENOG4105C2D	reductase
XFC3_00745	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
XFC3_00750	ENOG4108UT2	hemolysin iii
XFC3_00760	ENOG4105EYA	deoxyribonuclease
XFC3_00775	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
XFC3_00780	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
XFC3_00790	ENOG4107QX8	SPFH domain, Band 7 family protein
XFC3_00795	ENOG4105DXN	mazG family
XFC3_00800	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
XFC3_00805	ENOG4107RK2	ADP-ribose diphosphatase NudE
XFC3_00815	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
XFC3_00820	ENOG4105C1J	atp-dependent rna helicase
XFC3_00825	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
XFC3_00855	ENOG4108YXA	Membrane
XFC3_00860	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
XFC3_00865	ENOG4105C0B	DNA polymerase III (alpha subunit)
XFC3_00885	ENOG4105CRQ	synthase (Component I)
XFC3_00890	ENOG4105DDQ	anthranilate synthase
XFC3_00895	ENOG4107QYG	anthranilate phosphoribosyltransferase
XFC3_00900	ENOG4105DK0	Indole-3-glycerol phosphate synthase
XFC3_00920	ENOG4105DC7	peptidase M24
XFC3_00935	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
XFC3_00940	ENOG4105VIE	preprotein translocase, subunit YajC
XFC3_00945	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
XFC3_00950	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
XFC3_00960	ENOG4105DJ0	Poly(A) Polymerase
XFC3_00965	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFC3_00970	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
XFC3_00975	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
XFC3_00980	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
XFC3_00985	ENOG4107QP8	phosphohexose isomerase
XFC3_01000	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
XFC3_01005	ENOG4105CHV	Transcription elongation factor NusA
XFC3_01010	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
XFC3_01015	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
XFC3_01020	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
XFC3_01025	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
XFC3_01030	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
XFC3_01040	ENOG4105ECR	NmrA family
XFC3_01085	ENOG4105C10	Electron transfer flavoprotein
XFC3_01090	ENOG4105BZJ	Electron transfer flavoprotein
XFC3_01105	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
XFC3_01120	ENOG4107QKV	phosphomannomutase
XFC3_01155	ENOG4105CBP	Major Facilitator
XFC3_01170	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
XFC3_01175	ENOG4105DFU	Cell wall formation (By similarity)
XFC3_01180	ENOG410841Q	phosphoesterase PA-phosphatase related protein
XFC3_01190	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
XFC3_01195	ENOG4105C02	permease
XFC3_01215	ENOG4105C0H	protease
XFC3_01220	ENOG4105ECP	epimerase
XFC3_01225	ENOG4105CEY	Amp-dependent synthetase and ligase
XFC3_01230	ENOG4107QM5	aconitate hydratase
XFC3_01245	ENOG4107QIJ	Aconitate hydratase 2
XFC3_01265	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFC3_01320	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFC3_01330	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFC3_01340	ENOG4105GKE	subunit e
XFC3_01345	ENOG4107QIZ	NADH dehydrogenase
XFC3_01350	ENOG4108IEH	NADH dehydrogenase subunit g
XFC3_01360	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFC3_01365	ENOG4105DF2	NADH dehydrogenase subunit j
XFC3_01370	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFC3_01375	ENOG4105D65	subunit l
XFC3_01380	ENOG4105C8S	subunit m
XFC3_01385	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFC3_01390	ENOG4105CHR	reductase
XFC3_01395	ENOG4105D4T	Citrate transporter
XFC3_01410	ENOG4105DHQ	Histidine kinase
XFC3_01425	ENOG4105D7V	transposase
XFC3_01460	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
XFC3_01465	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFC3_01470	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
XFC3_01480	ENOG4105CDV	Ompa motb domain protein
XFC3_01490	ENOG4105CQB	FAD linked oxidase domain protein
XFC3_01495	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
XFC3_01500	ENOG4105KME	endoribonuclease L-psp
XFC3_01505	ENOG4105CB5	ATP-dependent DNA helicase recG
XFC3_01510	ENOG4106A3M	Cytochrome p-450
XFC3_01525	ENOG4105CDU	Replicative dna helicase
XFC3_01535	ENOG4105CDV	Ompa motb domain protein
XFC3_01540	ENOG4108RVA	ribokinase
XFC3_01545	ENOG4105CPC	Aldo Keto reductase
XFC3_01550	ENOG4108JQC	penicillin-binding protein 1A
XFC3_01585	ENOG4105DIJ	Phosphoethanolamine transferase
XFC3_01590	ENOG4106A3M	Cytochrome p-450
XFC3_01595	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
XFC3_01605	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
XFC3_01620	ENOG4105UGU	tonB-dependent Receptor
XFC3_01625	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
XFC3_01635	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
XFC3_01640	ENOG4105IFJ	Histidine kinase
XFC3_01645	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
XFC3_01660	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
XFC3_01670	ENOG4108UQY	Iron-storage protein
XFC3_01700	ENOG4105DU1	integral membrane protein, terc
XFC3_01705	ENOG4105DR4	Methyltransferase
XFC3_01710	ENOG4105CUB	amino acid
XFC3_01725	ENOG4107QSV	RmuC domain protein
XFC3_01750	ENOG4107PE3	Mammalian cell entry related domain protein
XFC3_01755	ENOG4105CY3	ABC transporter, permease
XFC3_01760	ENOG4105DHJ	ABC, transporter
XFC3_01765	ENOG4105DSY	exodeoxyribonuclease V, gamma
XFC3_01770	ENOG4107QKA	exodeoxyribonuclease V beta
XFC3_01785	ENOG4105C31	Tryptophanyl-tRNA synthetase
XFC3_01790	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFC3_01800	ENOG4105KTH	gatB Yqey
XFC3_01805	ENOG4105VCC	30S ribosomal protein S21
XFC3_01810	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
XFC3_01815	ENOG4107ZVW	dihydroneopterin aldolase
XFC3_01820	ENOG4105CUY	Mechanosensitive ion channel
XFC3_01825	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
XFC3_01840	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
XFC3_01850	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
XFC3_01865	ENOG4105M3Z	response regulator
XFC3_01875	ENOG4107QJR	hflk protein
XFC3_01880	ENOG4105EPW	hflc protein
XFC3_01890	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
XFC3_01895	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
XFC3_01900	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
XFC3_01905	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
XFC3_01925	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFC3_01930	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
XFC3_01935	ENOG4105D06	uba thif-type nad fad binding protein
XFC3_01945	ENOG41066DG	(EAL) domain protein
XFC3_01950	ENOG4105EWT	decarboxylase family
XFC3_01955	ENOG4106855	Competence protein
XFC3_01995	ENOG4105D7V	transposase
XFC3_02005	ENOG4105X0D	Fimbrial protein
XFC3_02035	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
XFC3_02040	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFC3_02045	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
XFC3_02050	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
XFC3_02055	ENOG41082RQ	UPF0102 protein
XFC3_02060	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
XFC3_02065	ENOG41090JD	Blue (Type 1) copper domain protein
XFC3_02075	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
XFC3_02090	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
XFC3_02105	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
XFC3_02120	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
XFC3_02130	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
XFC3_02150	ENOG4105C9K	Endothelin-converting enzyme 1
XFC3_02170	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
XFC3_02175	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
XFC3_02185	ENOG4105C02	permease
XFC3_02195	ENOG4108S0S	Nucleotidyl transferase
XFC3_02200	ENOG4105EHM	Aminoglycoside phosphotransferase
XFC3_02205	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
XFC3_02210	ENOG4105CJ2	(LipO)protein
XFC3_02230	ENOG4107E2E	PKHD-type hydroxylase
XFC3_02235	ENOG4108IU3	tonb-dependent siderophore receptor
XFC3_02255	ENOG4105C6T	cysteine synthase
XFC3_02270	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
XFC3_02275	ENOG4108DMA	Nad-dependent epimerase dehydratase
XFC3_02280	ENOG4108IAJ	Nad-dependent epimerase dehydratase
XFC3_02305	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
XFC3_02315	ENOG4105VF7	tolerance protein
XFC3_02320	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
XFC3_02325	ENOG4105DWF	phosphomethylpyrimidine kinase
XFC3_02330	ENOG4105E2X	shikimate dehydrogenase
XFC3_02425	ENOG4108V1T	peptidylprolyl cis-trans isomerase
XFC3_02435	ENOG4105CSM	endonuclease III
XFC3_02450	ENOG4108YZY	peptidylprolyl cis-trans isomerase
XFC3_02455	ENOG4105K4H	Nlp p60 protein
XFC3_02460	ENOG4105K4H	Nlp p60 protein
XFC3_02485	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
XFC3_02490	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
XFC3_02495	ENOG4105CTB	Polyprenyl synthetase
XFC3_02520	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
XFC3_02525	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
XFC3_02530	ENOG4105CHR	reductase
XFC3_02540	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFC3_02550	ENOG4105HHA	aminodeoxychorismate lyase
XFC3_02555	ENOG4107QRG	dna polymerase iii
XFC3_02575	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
XFC3_02580	ENOG4105ECY	inositol monophosphatase
XFC3_02590	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
XFC3_02600	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
XFC3_02605	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
XFC3_02610	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
XFC3_02640	ENOG4105KWW	Biogenesis protein
XFC3_02645	ENOG4107QX9	Thiol disulfide interChange protein
XFC3_02650	ENOG4105DA4	cytochrome c-type biogenesis protein
XFC3_02655	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
XFC3_02660	ENOG41060IM	Heme exporter protein
XFC3_02665	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
XFC3_02670	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
XFC3_02675	ENOG4105CHM	Aminotransferase
XFC3_02690	ENOG4105FE9	pseudouridine synthase
XFC3_02700	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
XFC3_02720	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
XFC3_02725	ENOG4105DRS	transport system, permease
XFC3_02745	ENOG4105DWY	Agmatine deiminase
XFC3_02755	ENOG4105CAT	Cytidine monophosphate kinase
XFC3_02760	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
XFC3_02765	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
XFC3_02775	ENOG4105CFV	Tetratricopeptide repeat protein
XFC3_02790	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
XFC3_02795	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
XFC3_02800	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
XFC3_02805	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
XFC3_02820	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
XFC3_02825	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
XFC3_02830	ENOG4105K46	50S ribosomal protein l27
XFC3_02835	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFC3_02840	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
XFC3_02845	ENOG4105CJR	Integral membrane protein (MviN
XFC3_02855	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
XFC3_02860	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
XFC3_02945	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
XFC3_02950	ENOG4108JJA	ABC, transporter
XFC3_02995	ENOG4105BZS	acriflavin resistance protein
XFC3_03000	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
XFC3_03005	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
XFC3_03020	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
XFC3_03025	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
XFC3_03030	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
XFC3_03045	ENOG4105D3Q	Sugar transferase
XFC3_03060	ENOG4107UFF	group 1 glycosyl transferase
XFC3_03075	ENOG4108NQK	Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a
XFC3_03080	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
XFC3_03085	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
XFC3_03090	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
XFC3_03095	ENOG41080ZE	Adenylate cyclase
XFC3_03100	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
XFC3_03105	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
XFC3_03115	ENOG4105VEQ	Cold shock protein
XFC3_03140	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFC3_03145	ENOG41090R7	Ferric uptake
XFC3_03150	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
XFC3_03155	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
XFC3_03160	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFC3_03165	ENOG4105CFG	Acts as a chaperone (By similarity)
XFC3_03170	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
XFC3_03180	ENOG4105ETX	regulatoR
XFC3_03185	ENOG41080IJ	Diacylglycerol kinase
XFC3_03190	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
XFC3_03195	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
XFC3_03210	ENOG4108IUW	ABC transporter
XFC3_03215	ENOG4108SDH	ABC, transporter
XFC3_03225	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
XFC3_03235	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
XFC3_03275	ENOG4105KUS	lysozyme
XFC3_03290	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
XFC3_03295	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
XFC3_03315	ENOG4105D52	delta-aminolevulinic acid dehydratase
XFC3_03320	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
XFC3_03335	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
XFC3_03340	ENOG4105D1F	ATP-binding protein
XFC3_03345	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
XFC3_03405	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
XFC3_03415	ENOG4107QJE	Chromosome Partitioning Protein
XFC3_03420	ENOG4105FA0	parb-like partition protein
XFC3_03440	ENOG410680H	amp-dependent synthetase and ligase
XFC3_03450	ENOG4105WPN	DNA integration recombination invertion protein
XFC3_03455	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
XFC3_03460	ENOG4105DSB	aldose 1-epimerase
XFC3_03470	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
XFC3_03475	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
XFC3_03480	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
XFC3_03490	ENOG4105EPD	Oligopeptide transporter, Opt family
XFC3_03495	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
XFC3_03500	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFC3_03515	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
XFC3_03525	ENOG4107QN1	sodium solute
XFC3_03530	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
XFC3_03535	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
XFC3_03540	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
XFC3_03545	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
XFC3_03555	ENOG4105C3F	Signal peptidase i
XFC3_03565	ENOG4105C0H	protease
XFC3_03575	ENOG4105EMN	RNA polymerase sigma factor
XFC3_03600	ENOG4108JQB	penicillin-binding protein 1C
XFC3_03615	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
XFC3_03625	ENOG4105DZ1	carboxypeptidase
XFC3_03630	ENOG4108UJU	UPF0301 protein
XFC3_03640	ENOG4105CXT	aspartate transcarbamylase
XFC3_03645	ENOG4105CFH	Aspartokinase
XFC3_03650	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
XFC3_03660	ENOG4105CUT	histidyl-tRNA synthetase
XFC3_03670	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
XFC3_03675	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
XFC3_03685	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
XFC3_03695	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
XFC3_03710	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
XFC3_03715	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
XFC3_03720	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
XFC3_03725	ENOG4105CUB	amino acid
XFC3_03730	ENOG4105CUB	amino acid
XFC3_03735	ENOG4108JQ1	Dehydrogenase
XFC3_03740	ENOG4105CQB	FAD linked oxidase domain protein
XFC3_03745	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
XFC3_03755	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
XFC3_03910	ENOG4105K6T	rare lipoprotein A
XFC3_03915	ENOG4105CVE	Lytic murein transglycosylase
XFC3_03940	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
XFC3_03955	ENOG4105C8T	Leucyl-tRNA synthetase
XFC3_03965	ENOG4105K63	Thioredoxin
XFC3_03970	ENOG4105F0N	pyrophosphate phospho-hydrolase
XFC3_03985	ENOG4105BZM	domain protein
XFC3_03990	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
XFC3_04000	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
XFC3_04005	ENOG4107RZZ	dna polymerase iii epsilon subunit
XFC3_04100	ENOG4105KUS	lysozyme
XFC3_04180	ENOG4108ZF3	Phosphatase
XFC3_04195	ENOG4105DKP	glycosyl transferase, family 9
XFC3_04200	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
XFC3_04210	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
XFC3_04215	ENOG4105NWN	ApaG protein
XFC3_04220	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
XFC3_04225	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
XFC3_04230	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
XFC3_04235	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
XFC3_04240	ENOG4105E2Z	phosphate ABC transporter (Permease
XFC3_04245	ENOG4105C8U	phosphate abc transporter
XFC3_04250	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
XFC3_04255	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
XFC3_04265	ENOG4107RNH	Outer membrane receptor FepA
XFC3_04270	ENOG4107ZXU	DSBA oxidoreductase
XFC3_04280	ENOG4105C5H	ABC transporter
XFC3_04315	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFC3_04410	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
XFC3_04430	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
XFC3_04435	ENOG4108Z0R	Transferase
XFC3_04440	ENOG4105BZS	acriflavin resistance protein
XFC3_04445	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
XFC3_04455	ENOG4105C7I	Dehydrogenase
XFC3_04460	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
XFC3_04490	ENOG4105BZS	acriflavin resistance protein
XFC3_04495	ENOG4105CHR	reductase
XFC3_04525	ENOG4105C26	Dehydrogenase
XFC3_04535	ENOG4105X54	addiction module antidote protein
XFC3_04595	ENOG4108IYH	Dna topoisomerase
XFC3_04720	ENOG4108C33	Resolvase
XFC3_04745	ENOG4105CJB	Exodeoxyribonuclease I
XFC3_04760	ENOG4105EEQ	Na H antiporter
XFC3_04770	ENOG4105E66	phosphoriboisomerase A
XFC3_04780	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
XFC3_04785	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
XFC3_04800	ENOG4107RAQ	aminopeptidase
XFC3_04840	ENOG4105CM2	brancheD-chain amino acid aminotransferase
XFC3_04845	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
XFC3_04865	ENOG4106WTF	Glycosyl transferase, family 2
XFC3_04875	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
XFC3_04880	ENOG4107ZT5	Thiol disulfide interchange protein
XFC3_04890	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
XFC3_04900	ENOG4105C2N	RNA methyltransferase TrmH family group 3
XFC3_04905	ENOG4108Z0R	Transferase
XFC3_04910	ENOG4105EUJ	GTP cyclohydrolase i
XFC3_04925	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
XFC3_04930	ENOG4105EM2	membrane
XFC3_04940	ENOG4105C12	Phosphoribosylglycinamide synthetase
XFC3_04945	ENOG4105DC1	bifunctional purine biosynthesis protein purh
XFC3_04955	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
XFC3_04965	ENOG4105E2T	synthase III
XFC3_04980	ENOG4108J2P	Alpha beta hydrolase fold
XFC3_04985	ENOG4105PI0	Ferredoxin
XFC3_04995	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
XFC3_05000	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
XFC3_05015	ENOG4105D7Z	glutathione synthase
XFC3_05020	ENOG4108UNF	response regulator
XFC3_05025	ENOG4108ZGA	chew protein
XFC3_05030	ENOG4105C8Q	Methyl-accepting chemotaxis
XFC3_05035	ENOG4105CBS	Chea signal transduction histidine kinase
XFC3_05050	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
XFC3_05065	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
XFC3_05075	ENOG4105DGW	oligopeptidase A
XFC3_05095	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
XFC3_05100	ENOG4105CK2	sodium dicarboxylate symporter
XFC3_05105	ENOG4105CV1	Transketolase (EC 2.2.1.1)
XFC3_05110	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
XFC3_05155	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
XFC3_05160	ENOG4108IYU	L-aspartate oxidase
XFC3_05165	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
XFC3_05175	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFC3_05215	ENOG4105F8V	Hydrolase, tatD family
XFC3_05230	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
XFC3_05235	ENOG4105CEN	a g-specific adenine glycosylase
XFC3_05240	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
XFC3_05245	ENOG4105CDY	transcriptional regulatory protein
XFC3_05250	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
XFC3_05255	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
XFC3_05260	ENOG4105DFH	Transport of potassium into the cell (By similarity)
XFC3_05265	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
XFC3_05270	ENOG4107YD3	Thioesterase
XFC3_05275	ENOG4105E02	MotA TolQ exbB proton channel
XFC3_05280	ENOG4105M8F	Biopolymer transport protein exbD tolR
XFC3_05290	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
XFC3_05295	ENOG4105KCK	Peptidoglycan-associated lipoprotein
XFC3_05305	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
XFC3_05310	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
XFC3_05315	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
XFC3_05320	ENOG4105DUX	Transporter
XFC3_05325	ENOG4108V06	Glutathione peroxidase
XFC3_05330	ENOG4105DP0	ferredoxin-NADP reductase
XFC3_05345	ENOG4105CVJ	phosphoglycerate mutase
XFC3_05510	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
XFC3_05515	ENOG4105C9M	aspartyl-trna synthetase
XFC3_05520	ENOG4107GFK	fumarate
XFC3_05620	ENOG4106GZK	Protein of unknown function (DUF2669)
XFC3_05640	ENOG4106GMR	
XFC3_05675	ENOG4108C66	Inherit from COG: DNA primase
XFC3_05720	ENOG4105KUS	lysozyme
XFC3_05740	ENOG4106FAK	Endodeoxyribonuclease RusA
XFC3_05845	ENOG4105H40	
XFC3_05850	ENOG4108HJ1	Uncharacterized conserved protein (DUF2303)
XFC3_05880	ENOG4108UUM	single-stranded DNA-binding protein
XFC3_05895	ENOG4105CUX	Signal transduction histidine kinase
XFC3_05900	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
XFC3_05910	ENOG4105BZU	Histidine kinase
XFC3_05920	ENOG4105C5F	glutamine synthetase
XFC3_05925	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
XFC3_05930	ENOG4108YYC	ycei family
XFC3_05950	ENOG4105RKW	reductase (By
XFC3_05960	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
XFC3_05985	ENOG4105D6Z	AFG1 family ATPase
XFC3_05990	ENOG4108ZHJ	Organic hydroperoxide resistance protein
XFC3_05995	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
XFC3_06000	ENOG4105CN1	protease
XFC3_06005	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
XFC3_06020	ENOG4105C7B	Threonine dehydratase
XFC3_06025	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
XFC3_06030	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
XFC3_06035	ENOG4105VGS	50s ribosomal protein l32
XFC3_06040	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
XFC3_06050	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
XFC3_06060	ENOG4105F8C	transglutaminase domain-containing protein
XFC3_06070	ENOG4105K59	histidine triad (HIT) protein
XFC3_06075	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
XFC3_06080	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
XFC3_06085	ENOG4107QMP	dna polymerase iii subunits gamma and tau
XFC3_06110	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
XFC3_06115	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
XFC3_06120	ENOG4107YZP	Rhodanese domain protein
XFC3_06145	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
XFC3_06150	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
XFC3_06195	ENOG4107QJE	Chromosome Partitioning Protein
XFC3_06235	ENOG4107YH6	single-stranded DNA-binding protein
XFC3_06245	ENOG4105NI8	Cytosine-specific methyltransferase
XFC3_06290	ENOG4105EQ2	LysR family Transcriptional regulator
XFC3_06380	ENOG4105EQ2	LysR family Transcriptional regulator
XFC3_06390	ENOG4105ENX	hydrolase
XFC3_06395	ENOG4107RTG	Major Facilitator superfamily
XFC3_06410	ENOG4105DQ4	alcohol dehydrogenase
XFC3_06415	ENOG4105ENX	hydrolase
XFC3_06420	ENOG4105EMU	Dehydrogenase
XFC3_06430	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
XFC3_06435	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
XFC3_06440	ENOG4105D8V	Glucose sorbosone dehydrogenase
XFC3_06465	ENOG4105D8V	Glucose sorbosone dehydrogenase
XFC3_06470	ENOG4105DQ4	alcohol dehydrogenase
XFC3_06480	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
XFC3_06485	ENOG4105HEI	LysR family (Transcriptional regulator
XFC3_06515	ENOG4105CPC	Aldo Keto reductase
XFC3_06535	ENOG4105DFP	Integrase
XFC3_06545	ENOG4105DFA	alanine racemase domain protein
XFC3_06550	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
XFC3_06555	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
XFC3_06560	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
XFC3_06575	ENOG4105M4H	endoribonuclease L-psp
XFC3_06595	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFC3_06605	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
XFC3_06635	ENOG4105CZX	twitching motility protein
XFC3_06650	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
XFC3_06655	ENOG4108NEV	two component transcriptional regulator, LytTR family
XFC3_06660	ENOG4108HRK	Histidine kinase
XFC3_06670	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
XFC3_06685	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFC3_06700	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
XFC3_06710	ENOG4105D7K	pfkb domain protein
XFC3_06730	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
XFC3_06740	ENOG4108V06	Glutathione peroxidase
XFC3_06750	ENOG4105CZV	ABC transporter
XFC3_06770	ENOG4105VUH	addiction module killer protein
XFC3_06775	ENOG4105YES	addiction module antidote protein
XFC3_06815	ENOG4106GZK	Protein of unknown function (DUF2669)
XFC3_06835	ENOG4106GMR	
XFC3_06870	ENOG4108C66	Inherit from COG: DNA primase
XFC3_06905	ENOG4105KUS	lysozyme
XFC3_06925	ENOG4106FAK	Endodeoxyribonuclease RusA
XFC3_06945	ENOG4108UUM	single-stranded DNA-binding protein
XFC3_06960	ENOG4105C9Q	fumarate hydratase class II
XFC3_06970	ENOG4107QTF	adenylosuccinate lyase
XFC3_06985	ENOG4105C7S	Dehydrogenase
XFC3_07005	ENOG4105CUZ	uba thif-type nad fad binding protein
XFC3_07020	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
XFC3_07025	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
XFC3_07030	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
XFC3_07035	ENOG4108UJD	30S ribosomal protein S9
XFC3_07040	ENOG4105BZN	citrate synthase
XFC3_07045	ENOG4105NRA	50s ribosomal protein l31 type b
XFC3_07050	ENOG41072GX	Peptidase M22 Glycoprotease
XFC3_07055	ENOG4105C5Q	Transcriptional regulator
XFC3_07065	ENOG4105D3R	alkyl hydroperoxide reductase
XFC3_07075	ENOG4105GVR	general secretion pathway protein D
XFC3_07085	ENOG410678M	general secretion pathway protein M
XFC3_07090	ENOG41090VX	general secretion pathway protein L
XFC3_07095	ENOG4105UV2	general secretion pathway protein K
XFC3_07100	ENOG41069G9	General secretion pathway protein J
XFC3_07110	ENOG4105WMT	general secretion pathway protein h
XFC3_07120	ENOG4105D7Q	type ii secretion system
XFC3_07125	ENOG4107QHF	type ii secretion system protein e
XFC3_07130	ENOG4105EUR	Domain-Containing protein
XFC3_07150	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
XFC3_07155	ENOG4108HGY	Proline imino-peptidase
XFC3_07170	ENOG4105CSA	Coproporphyrinogen iii oxidase
XFC3_07175	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
XFC3_07185	ENOG4105DSJ	YicC domain protein
XFC3_07190	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
XFC3_07195	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
XFC3_07200	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
XFC3_07205	ENOG4105C11	sulfate adenylyltransferase), subunit 2
XFC3_07210	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
XFC3_07215	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
XFC3_07220	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
XFC3_07235	ENOG41063JG	Transcriptional regulator
XFC3_07260	ENOG4105CD8	aminopeptidase N
XFC3_07265	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFC3_07300	ENOG4105WXW	Antirepressor
XFC3_07410	ENOG4105KUS	lysozyme
XFC3_07480	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
XFC3_07555	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
XFC3_07565	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
XFC3_07575	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
XFC3_07600	ENOG4105C3K	feS assembly ATPase SufC
XFC3_07610	ENOG4105C9B	Cysteine desulfurase
XFC3_07620	ENOG4107QPH	glycogen) synthase
XFC3_07625	ENOG4107BJW	polysaccharide deacetylase
XFC3_07630	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
XFC3_07635	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
XFC3_07640	ENOG4105CE4	GlcNAc 6-P deacetylase
XFC3_07645	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
XFC3_07650	ENOG4105ETE	Transcriptional regulator (LacI family
XFC3_07665	ENOG4105CHC	glucokinase (EC 2.7.1.2)
XFC3_07680	ENOG410642E	Short chain dehydrogenase
XFC3_07690	ENOG4105BZU	Histidine kinase
XFC3_07695	ENOG4105WMR	Protein CrcB homolog
XFC3_07700	ENOG4105D1H	recombination factor protein RarA
XFC3_07705	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
XFC3_07715	ENOG4105CNU	cell division protein FtsK
XFC3_07720	ENOG4105C3M	thioredoxin reductase
XFC3_07730	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
XFC3_07735	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
XFC3_07740	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
XFC3_07745	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
XFC3_07755	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
XFC3_07760	ENOG41075W9	High frequency lysogenization protein HflD homolog
XFC3_07770	ENOG4108Z33	Thiol disulfide Interchange Protein
XFC3_07775	ENOG4108Z33	Thiol disulfide Interchange Protein
XFC3_07790	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
XFC3_07795	ENOG4105D1K	glutamate--cysteine ligase
XFC3_07805	ENOG4105EYW	Ion transport protein
XFC3_07810	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
XFC3_07815	ENOG4105T95	Thiol disulfide interChange protein
XFC3_07855	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
XFC3_07865	ENOG4105C2X	Arabinose 5-phosphate isomerase
XFC3_07870	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
XFC3_07885	ENOG4108IUZ	ABC transporter
XFC3_07890	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
XFC3_07895	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
XFC3_07905	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
XFC3_07915	ENOG41080Z8	PHOSPHOCARRIER protein
XFC3_07920	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
XFC3_07925	ENOG4105CJW	magnesium transporter
XFC3_07945	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
XFC3_07950	ENOG4108UUM	single-stranded DNA-binding protein
XFC3_07955	ENOG4105EAH	synthase
XFC3_07960	ENOG4105E2S	oxidase) subunit II
XFC3_07965	ENOG4105BZ9	Cytochrome C oxidase, subunit I
XFC3_07970	ENOG4105CCU	oxidase (Subunit III)
XFC3_07975	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
XFC3_07980	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFC3_07995	ENOG4105CQ7	ATP-dependent helicase
XFC3_08005	ENOG4105C9U	ATP-dependent DNA helicase RecQ
XFC3_08015	ENOG4108M8W	Monooxygenase
XFC3_08020	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
XFC3_08025	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
XFC3_08030	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
XFC3_08035	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
XFC3_08040	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
XFC3_08050	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
XFC3_08055	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
XFC3_08060	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
XFC3_08070	ENOG4105DJ4	phosphatidylserine decarboxylase
XFC3_08080	ENOG4107SC1	transglycosylase
XFC3_08085	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
XFC3_08090	ENOG4107U32	Beta-lactamase domain protein
XFC3_08095	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
XFC3_08105	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
XFC3_08110	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
XFC3_08120	ENOG4105NTK	Transcriptional repressor Mpra
XFC3_08125	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFC3_08130	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
XFC3_08140	ENOG4108IJ6	ABC transporter
XFC3_08150	ENOG4108I5D	sulfate abc transporter
XFC3_08155	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
XFC3_08165	ENOG4106N3A	copper homeostasis protein cutc
XFC3_08175	ENOG4105CX6	glutaminyL-tRNA synthetase
XFC3_08180	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
XFC3_08190	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
XFC3_08195	ENOG4105D49	3-dehydroquinate synthase
XFC3_08200	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
XFC3_08210	ENOG4108YYC	ycei family
XFC3_08215	ENOG4108VKM	cytochrome b561
XFC3_08245	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
XFC3_08250	ENOG4107QMS	site-determining protein
XFC3_08270	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
XFC3_08275	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
XFC3_08280	ENOG4105CNI	cell division protein FtsW
XFC3_08285	ENOG4105CJN	penicillin-binding protein
XFC3_08300	ENOG4105DFF	Rod shape-determining protein mreb
XFC3_08345	ENOG4105DHJ	ABC, transporter
XFC3_08350	ENOG4108SNX	Mammalian cell entry related domain protein
XFC3_08365	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
XFC3_08375	ENOG4108DG9	Smr protein MutS2
XFC3_08380	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
XFC3_08385	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
XFC3_08390	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
XFC3_08395	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
XFC3_08400	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
XFC3_08405	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
XFC3_08415	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFC3_08440	ENOG4106BRA	Membrane
XFC3_08465	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
XFC3_08470	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
XFC3_08475	ENOG41065HY	1,4-beta-cellobiosidase
XFC3_08495	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
XFC3_08510	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
XFC3_08535	ENOG4105DN3	alpha-2-macroglobulin domain protein
XFC3_08560	ENOG4105C7F	AcnD-accessory protein PrpF
XFC3_08565	ENOG4108I0Z	Aconitate hydratase
XFC3_08600	ENOG4105CR4	methylisocitrate lyase
XFC3_08605	ENOG4105MA0	exported protein
XFC3_08610	ENOG4105CFU	surface antigen
XFC3_08620	ENOG4105CQ7	ATP-dependent helicase
XFC3_08640	ENOG4105DA5	(ABC) transporter
XFC3_08645	ENOG4105E3A	(ABC) transporter
XFC3_08650	ENOG4108JJA	ABC, transporter
XFC3_08660	ENOG4108MBX	Secretion Protein
XFC3_08670	ENOG4105CI3	gtp-binding protein typa
XFC3_08675	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
XFC3_08680	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
XFC3_08685	ENOG4108K3A	Glutathione S-transferase
XFC3_08690	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
XFC3_08725	ENOG4105I08	Pseudouridine synthase
XFC3_08740	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
XFC3_08745	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
XFC3_08760	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
XFC3_08775	ENOG4105K70	DNA-binding protein
XFC3_08785	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
XFC3_08790	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
XFC3_08795	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
XFC3_08810	ENOG4107QQG	Dehydrogenase
XFC3_08820	ENOG4105MGK	May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity)
XFC3_08830	ENOG4105C0P	Mg chelatase subunit ChlI
XFC3_08835	ENOG4105W0Z	cytoplasmic protein
XFC3_08840	ENOG4108ZT0	50S ribosomal protein l17
XFC3_08850	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
XFC3_08855	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
XFC3_08860	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFC3_08865	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
XFC3_08870	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
XFC3_08875	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
XFC3_08880	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
XFC3_08885	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
XFC3_08890	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
XFC3_08895	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFC3_08900	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
XFC3_08905	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
XFC3_08910	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
XFC3_08915	ENOG41083MP	50s ribosomal protein l29
XFC3_08925	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
XFC3_08930	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
XFC3_08940	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFC3_08945	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
XFC3_08950	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
XFC3_08955	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
XFC3_08965	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
XFC3_08970	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFC3_08975	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFC3_08980	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFC3_08985	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
XFC3_08990	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
XFC3_08995	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
XFC3_09000	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
XFC3_09010	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
XFC3_09025	ENOG4105DQ4	alcohol dehydrogenase
XFC3_09040	ENOG4105CC0	LysR family Transcriptional regulator
XFC3_09045	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
XFC3_09050	ENOG4105N42	UPF0307 protein
XFC3_09055	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
XFC3_09065	ENOG4105C03	ribonuclease
XFC3_09070	ENOG4108Z03	MAF-like protein
XFC3_09080	ENOG4105SYT	Methylenetetrahydrofolate reductase
XFC3_09085	ENOG4105M6F	mutator MutT protein
XFC3_09095	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
XFC3_09110	ENOG4105E39	Enoyl-CoA hydratase
XFC3_09115	ENOG4105BZU	Histidine kinase
XFC3_09120	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
XFC3_09125	ENOG4105CRK	lysyL-tRNA synthetase
XFC3_09130	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
XFC3_09135	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
XFC3_09145	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
XFC3_09150	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
XFC3_09155	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
XFC3_09160	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
XFC3_09170	ENOG4105C2M	dna polymerase I
XFC3_09185	ENOG4107RH7	Nicotinate phosphoribosyltransferase
XFC3_09190	ENOG4105CS1	NAD(P)H quinone oxidoreductase
XFC3_09200	ENOG4107RZC	phospholipase d
XFC3_09220	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
XFC3_09225	ENOG4105BZ1	(ABC) transporter
XFC3_09240	ENOG4108EC8	DNA internalization-related competence protein ComEC
XFC3_09245	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
XFC3_09250	ENOG4105D60	lipoprotein releasing system transmembrane protein
XFC3_09290	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
XFC3_09295	ENOG4108IJ9	(ABC) transporter
XFC3_09300	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
XFC3_09305	ENOG4105CHC	glucokinase (EC 2.7.1.2)
XFC3_09310	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
XFC3_09315	ENOG4105C01	Dihydroxy-acid dehydratase
XFC3_09320	ENOG4108UHU	Aldolase
XFC3_09345	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
XFC3_09360	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
XFC3_09365	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
XFC3_09370	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
XFC3_09375	ENOG4105KNE	Phosphatidate cytidylyltransferase
XFC3_09380	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
XFC3_09385	ENOG4105DZP	Membrane-associated zinc metalloprotease
XFC3_09395	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFC3_09400	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
XFC3_09405	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFC3_09410	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFC3_09415	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
XFC3_09425	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
XFC3_09460	ENOG4105C29	acyl-CoA thioesterase
XFC3_09470	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
XFC3_09475	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
XFC3_09480	ENOG4105KST	dependent repressor
XFC3_09485	ENOG4108Z6B	deaminase
XFC3_09490	ENOG4105DDI	hemolysin-type calcium-binding region
XFC3_09520	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
XFC3_09525	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
XFC3_09530	ENOG4105CH7	arginosuccinase
XFC3_09535	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
XFC3_09540	ENOG4105CAS	nag kinase
XFC3_09550	ENOG4105CDH	Citrulline--aspartate ligase
XFC3_09555	ENOG4105DBV	ornithine carbamoyltransferase
XFC3_09565	ENOG4105C8N	cysteinyl-tRNA synthetase
XFC3_09570	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
XFC3_09575	ENOG4105E8G	Major facilitator Superfamily
XFC3_09585	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XFC3_09590	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
XFC3_09595	ENOG4105CD3	dihydroorotase
XFC3_09605	ENOG4105BZU	Histidine kinase
XFC3_09615	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
XFC3_09625	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
XFC3_09630	ENOG4106H78	methyltransferase
XFC3_09635	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
XFC3_09640	ENOG4105C6K	Malic enzyme
XFC3_09645	ENOG4105CK2	sodium dicarboxylate symporter
XFC3_09780	ENOG4105KUS	lysozyme
XFC3_09865	ENOG4105WXW	Antirepressor
XFC3_09970	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
XFC3_10040	ENOG4105KUS	lysozyme
XFC3_10150	ENOG4105WXW	Antirepressor
XFC3_10190	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
XFC3_10205	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
XFC3_10215	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFC3_10235	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
XFC3_10240	ENOG4107YIM	Involved in the transcription termination process (By similarity)
XFC3_10245	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
XFC3_10250	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
XFC3_10260	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
XFC3_10265	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
XFC3_10275	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
XFC3_10280	ENOG4105C5H	ABC transporter
XFC3_10285	ENOG4105DWT	malate dehydrogenase (quinone)
XFC3_10290	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
XFC3_10300	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
XFC3_10305	ENOG4105C34	Pseudouridine synthase
XFC3_10310	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFC3_10330	ENOG4105CE1	Ferrous iron transport protein b
XFC3_10345	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
XFC3_10355	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
XFC3_10370	ENOG4105C79	DNA protecting protein DprA
XFC3_10375	ENOG4108RPN	Protein smg homolog
XFC3_10380	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFC3_10385	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
XFC3_10420	ENOG4105KB2	stringent starvation protein b
XFC3_10425	ENOG4107MKT	Stringent starvation protein a
XFC3_10430	ENOG4105EIX	cytochrome c1
XFC3_10435	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
XFC3_10440	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
XFC3_10445	ENOG4105E4C	Lytic transglycosylase catalytic
XFC3_10450	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
XFC3_10455	ENOG4105C9A	Phoh family
XFC3_10460	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
XFC3_10470	ENOG4108JU5	Magnesium and cobalt efflux protein
XFC3_10595	ENOG4105BZ4	penicillin-binding protein
XFC3_10605	ENOG4105DVT	helicase
XFC3_10615	ENOG41077A9	carbonic anhydrase
XFC3_10630	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
XFC3_10635	ENOG4108UMI	ABC transporter, permease
XFC3_10640	ENOG4105D01	(LipO)protein
XFC3_10650	ENOG4107QSN	dihydrolipoamide acetyltransferase
XFC3_10655	ENOG4107QN2	dihydrolipoyl dehydrogenase
XFC3_10670	ENOG4105C28	cystathionine
XFC3_10675	ENOG4106TYC	homoserine o-acetyltransferase (EC 2.3.1.31)
XFC3_10680	ENOG4105DR5	peptidase
XFC3_10685	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
XFC3_10690	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
XFC3_10695	ENOG4108UM1	dedA family
XFC3_10700	ENOG4108K5P	(LipO)protein
XFC3_10715	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
XFC3_10720	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
XFC3_10725	ENOG4105E0X	reductase
XFC3_10730	ENOG4105VRS	hydrolase family 18
XFC3_10735	ENOG4105E2D	ec 3.2.1.52
XFC3_10760	ENOG4105CWX	Alpha-1,2-mannosidase
XFC3_10770	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
XFC3_10775	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
XFC3_10780	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
XFC3_10785	ENOG4105D0A	hydroxylase
XFC3_10790	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
XFC3_10795	ENOG4107R11	Transcriptional regulator
XFC3_10825	ENOG4107R1Y	fructose-bisphosphate aldolase
XFC3_10830	ENOG4105CA9	Pyruvate kinase
XFC3_10835	ENOG4105BZA	Phosphoglycerate kinase
XFC3_10840	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
XFC3_10845	ENOG4105MYN	Zinc uptake regulation protein
XFC3_10855	ENOG4106R7G	Glycoside hydrolase family 5
XFC3_10875	ENOG4108YQE	rare lipoprotein a
XFC3_10880	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
XFC3_10885	ENOG4105DR5	peptidase
XFC3_10895	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFC3_10900	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
XFC3_10905	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
XFC3_10910	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
XFC3_10915	ENOG4105CPF	Cell wall formation (By similarity)
XFC3_10920	ENOG4105DFU	Cell wall formation (By similarity)
XFC3_10925	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
XFC3_10935	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
XFC3_10940	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
XFC3_10945	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
XFC3_10950	ENOG4105CJN	penicillin-binding protein
XFC3_10955	ENOG4106932	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
XFC3_10960	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
XFC3_10965	ENOG4108V6E	Cell division protein mraZ
XFC3_10980	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
XFC3_10985	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
XFC3_10990	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
XFC3_11045	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
XFC3_11070	ENOG4107QPB	Beta-lactamase domain protein
XFC3_11075	ENOG41080HT	Transcriptional regulator, arsr family
XFC3_11080	ENOG4105MD1	YeeE YedE family protein
XFC3_11085	ENOG4105KFG	YeeE YedE family protein
XFC3_11090	ENOG4108VCT	Sulfite exporter TauE/SafE
XFC3_11095	ENOG4105DHP	deoxycytidine triphosphate deaminase
XFC3_11105	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
XFC3_11110	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
XFC3_11115	ENOG4105K8N	protein family UPF0079, ATPase
XFC3_11120	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
XFC3_11130	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
XFC3_11155	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
XFC3_11170	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
XFC3_11175	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
XFC3_11180	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
XFC3_11185	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
XFC3_11195	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
XFC3_11200	ENOG4105C22	threonyL-tRNA synthetase
XFC3_11270	ENOG4105RT5	Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation
XFC3_11275	ENOG4105WJ3	XRE family Transcriptional regulator
XFC3_11345	ENOG4105KUS	lysozyme
XFC3_11450	ENOG4105WXW	Antirepressor
XFC3_11480	ENOG4108I1J	Integrase
XFC3_11495	ENOG4105ETX	regulatoR
XFC3_11505	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
XFC3_11510	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
XFC3_11540	ENOG4107QHF	type ii secretion system protein e
XFC3_11545	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
XFC3_11560	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
XFC3_11565	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
XFC3_11575	ENOG4105D5K	Hemolysin activator protein
XFC3_11585	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFC3_11590	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
XFC3_11600	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
XFC3_11610	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
XFC3_11615	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
XFC3_11625	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
XFC3_11630	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
XFC3_11640	ENOG4108Z4V	iron-sulfur cluster assembly
XFC3_11645	ENOG4105C5S	asparaginyl-tRNA synthetase
XFC3_11665	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
XFC3_11670	ENOG4105D4A	Cell wall formation (By similarity)
XFC3_11675	ENOG4108SXK	Transporter Drug Metabolite Exporter family
XFC3_11680	ENOG410841Q	phosphoesterase PA-phosphatase related protein
XFC3_11685	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
XFC3_11700	ENOG4108UYB	regulatoR
XFC3_11705	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
XFC3_11720	ENOG4105BZ1	(ABC) transporter
XFC3_11725	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
XFC3_11730	ENOG4105DFG	type I secretion outer membrane protein
XFC3_11735	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
XFC3_11740	ENOG4105C9X	ppx gppa phosphatase
XFC3_11745	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
XFC3_11750	ENOG4105BZU	Histidine kinase
XFC3_11755	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
XFC3_11760	ENOG4105ERG	peptidase m48, ste24p
XFC3_11765	ENOG4105VW4	glutaredoxin 3
XFC3_11770	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
XFC3_11780	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
XFC3_11790	ENOG4108Z4U	Ferredoxin
XFC3_11800	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
XFC3_11805	ENOG41090A4	Pterin carbinolamine dehydratase
XFC3_11815	ENOG4105EI2	Pseudouridine synthase
XFC3_11820	ENOG4105C03	ribonuclease
XFC3_11830	ENOG4105C72	UPF0176 protein
XFC3_11840	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFC3_11855	ENOG4105C5H	ABC transporter
XFC3_11860	ENOG4105CNG	UPF0061 protein
XFC3_11875	ENOG4105D0M	Protease HtpX homolog
XFC3_11880	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
XFC3_11885	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
XFC3_11890	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
XFC3_11895	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
XFC3_11900	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
XFC3_11905	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
XFC3_11910	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
XFC3_11915	ENOG4108VZM	50s ribosomal protein L10
XFC3_11920	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
XFC3_11925	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
XFC3_11930	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
XFC3_11935	ENOG4105PM1	preprotein translocase subunit SecE
XFC3_11945	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
XFC3_11965	ENOG4105C3G	gtp-binding protein
XFC3_11970	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
XFC3_11975	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
XFC3_11980	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
XFC3_11990	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
XFC3_11995	ENOG4108D76	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
XFC3_12000	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
XFC3_12005	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
XFC3_12010	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
XFC3_12015	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
XFC3_12055	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
XFC3_12060	ENOG4105M2J	Glutaredoxin
XFC3_12065	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
XFC3_12070	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
XFC3_12075	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
XFC3_12085	ENOG4107STQ	Multicopper oxidase
XFC3_12095	ENOG4105C4R	Atp-dependent dna helicase
XFC3_12100	ENOG4105DJ9	glucan biosynthesis protein
XFC3_12105	ENOG4105D07	Signal peptide peptidase, SppA
XFC3_12110	ENOG4107QI1	Mate efflux family protein
XFC3_12125	ENOG4105C25	Primosomal protein n'
XFC3_12135	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
XFC3_12140	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
XFC3_12145	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
XFC3_12150	ENOG4105CAK	Cell division ATP-binding protein ftsE
XFC3_12155	ENOG4105C1J	atp-dependent rna helicase
XFC3_12160	ENOG4105K63	Thioredoxin
XFC3_12165	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
XFC3_12170	ENOG4105E9K	Isocitrate dehydrogenase
XFC3_12180	ENOG4105CN1	protease
XFC3_12185	ENOG41063SB	peptidase
XFC3_12200	ENOG4105BZ8	glutamate synthase
XFC3_12205	ENOG4105CBC	glutamate synthase
XFC3_12210	ENOG4105II7	pyrroline-5-carboxylate reductase
XFC3_12230	ENOG4105UBK	short-chain dehydrogenase reductase
XFC3_12255	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFC3_12275	ENOG41082EK	Restriction modification system DNA (Specificity
XFC3_12290	ENOG410829K	Lysine exporter protein (Lyse ygga)
XFC3_12305	ENOG4105E7D	Protein of unknown function (DUF3375)
XFC3_12345	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFC3_12360	ENOG4105CVR	type I restriction-modification system
XFC3_12480	ENOG4105YES	addiction module antidote protein
XFC3_12485	ENOG4105VUH	addiction module killer protein
XFC3_12580	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
XFC3_12590	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
XFC3_12595	ENOG4107FTS	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)