locus-tag	class	description
XF_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XF_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XF_0005	COG0187	DNA topoisomerase II activity
XF_0006	COG0501	Belongs to the peptidase M48B family
XF_0017	COG0408	coproporphyrinogen oxidase activity
XF_0026	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XF_0028	COG4969	Belongs to the N-Me-Phe pilin family
XF_0034	COG0284	orotidine-5'-phosphate decarboxylase activity
XF_0039	COG1970	mechanosensitive ion channel activity
XF_0043	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XF_0045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XF_0047	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XF_0048	COG0511	ligase activity, forming carbon-carbon bonds
XF_0049	COG0439	Biotin carboxylase
XF_0050	COG0210	DNA helicase
XF_0053	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XF_0053	COG1017	nitric oxide dioxygenase activity
XF_0060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XF_0063	COG1040	competence protein
XF_0064	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XF_0066	COG1752	Esterase of the alpha-beta hydrolase superfamily
XF_0068	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XF_0071	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XF_0073	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XF_0078	COG3539	Fimbrial protein
XF_0082	COG3121	Chaperone
XF_0083	COG3539	Fimbrial protein
XF_0086	COG1546	Belongs to the CinA family
XF_0087	COG0477	Major facilitator Superfamily
XF_0088	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XF_0089	COG1923	regulation of RNA biosynthetic process
XF_0090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XF_0091	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XF_0093	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XF_0094	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XF_0095	COG1534	Rna-binding protein
XF_0099	COG0129	dihydroxy-acid dehydratase activity
XF_0104	COG1560	Kdo2-lipid A biosynthetic process
XF_0105	COG1519	Transferase
XF_0107	COG0228	four-way junction DNA binding
XF_0108	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XF_0109	COG0336	Belongs to the RNA methyltransferase TrmD family
XF_0110	COG0335	large ribosomal subunit rRNA binding
XF_0111	COG0024	Methionine aminopeptidase
XF_0114	COG2171	N-acyltransferase activity
XF_0115	COG1393	Belongs to the ArsC family
XF_0116	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XF_0118	COG0367	asparagine synthase
XF_0121	COG2070	2-Nitropropane dioxygenase
XF_0122	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XF_0123	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XF_0124	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XF_0127	COG0339	signal peptide processing
XF_0132	COG2132	Multicopper oxidase
XF_0134	COG0525	valine-tRNA ligase activity
XF_0138	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XF_0141	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XF_0143	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XF_0144	COG1166	arginine decarboxylase activity
XF_0145	COG4221	oxidoreductase activity
XF_0147	COG0018	arginyl-trna synthetase
XF_0148	COG2003	Belongs to the UPF0758 family
XF_0149	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XF_0150	COG0756	dUTP diphosphatase activity
XF_0151	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XF_0153	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XF_0165	COG2223	nitrite transmembrane transporter activity
XF_0166	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XF_0167	COG0739	heme binding
XF_0169	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XF_0170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XF_0173	COG1028	Short-chain dehydrogenase reductase Sdr
XF_0174	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XF_0175	COG1272	protein, Hemolysin III
XF_0176	COG0463	Glycosyl transferase, family 2
XF_0177	COG0084	hydrolase, TatD family'
XF_0181	COG0509	glycine decarboxylation via glycine cleavage system
XF_0183	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XF_0185	COG0330	HflC and HflK could
XF_0186	COG3956	TIGRFAM MazG family protein
XF_0187	COG1218	3'(2'),5'-bisphosphate nucleotidase
XF_0188	COG0494	nUDIX hydrolase
XF_0190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XF_0192	COG0513	Belongs to the DEAD box helicase family
XF_0193	COG0720	synthase
XF_0203	COG0825	malonyl-CoA metabolic process
XF_0204	COG0587	DNA-directed DNA polymerase activity
XF_0205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XF_0211	COG0512	Glutamine amidotransferase of anthranilate synthase
XF_0212	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XF_0213	COG0134	indole-3-glycerol-phosphate synthase activity
XF_0220	COG0006	proline dipeptidase activity
XF_0223	COG0343	queuine tRNA-ribosyltransferase activity
XF_0224	COG1862	Preprotein translocase
XF_0225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XF_0226	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XF_0227	COG0617	tRNA 3'-terminal CCA addition
XF_0229	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XF_0230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XF_0231	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XF_0232	COG0166	Belongs to the GPI family
XF_0233	COG0779	Required for maturation of 30S ribosomal subunits
XF_0234	COG0195	Participates in both transcription termination and antitermination
XF_0235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XF_0236	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XF_0237	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XF_0238	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XF_0239	COG1185	polyribonucleotide nucleotidyltransferase activity
XF_0240	COG1733	regulation of RNA biosynthetic process
XF_0241	COG0702	epimerase
XF_0254	COG2086	electron transfer activity
XF_0260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XF_0268	COG0477	Major facilitator Superfamily
XF_0275	COG0563	adenylate kinase activity
XF_0276	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XF_0277	COG0671	phosphoesterase, PA-phosphatase related
XF_0280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XF_0281	COG0628	permease
XF_0285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XF_0286	COG1090	epimerase
XF_0287	COG0318	PFAM AMP-dependent synthetase and ligase
XF_0292	COG1049	propionate catabolic process, 2-methylcitrate cycle
XF_0300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XF_0303	COG0149	triose-phosphate isomerase activity
XF_0305	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XF_0306	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XF_0307	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XF_0308	COG0649	NAD binding
XF_0309	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XF_0310	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XF_0311	COG1034	ATP synthesis coupled electron transport
XF_0312	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XF_0313	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XF_0315	COG0713	ATP synthesis coupled electron transport
XF_0318	COG1007	ATP synthesis coupled electron transport
XF_0319	COG1028	Short-chain dehydrogenase reductase Sdr
XF_0320	COG2851	Citrate transporter
XF_0323	COG0642	Histidine kinase
XF_0326	COG0675	Transposase, IS605 OrfB family
XF_0338	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XF_0339	COG4206	TonB-dependent receptor
XF_0340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XF_0347	COG0277	FAD linked oxidase domain protein
XF_0352	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XF_0354	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XF_0356	COG2124	cytochrome p450
XF_0361	COG0305	Participates in initiation and elongation during chromosome replication
XF_0366	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XF_0367	COG0667	Aldo Keto reductase
XF_0368	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XF_0375	COG2194	sulfuric ester hydrolase activity
XF_0377	COG2124	cytochrome p450
XF_0378	COG0352	thiamine-phosphate diphosphorylase activity
XF_0381	COG0542	response to heat
XF_0387	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XF_0389	COG0745	RESPONSE REGULATOR receiver
XF_0390	COG2205	protein histidine kinase activity
XF_0392	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XF_0393	COG0494	nUDIX hydrolase
XF_0395	COG2193	ferroxidase activity
XF_0406	COG0861	Integral membrane protein TerC family
XF_0407	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XF_0408	COG0531	amino acid
XF_0412	COG1116	anion transmembrane transporter activity
XF_0413	COG1322	Protein conserved in bacteria
XF_0416	COG2853	Lipoprotein
XF_0419	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XF_0420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XF_0421	COG1127	ABC transporter
XF_0422	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XF_0423	COG1074	ATP-dependent DNA helicase activity
XF_0428	COG0180	Tryptophanyl-tRNA synthetase
XF_0430	COG0358	DNA primase activity
XF_0433	COG1610	YqeY-like protein
XF_0434	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XF_0435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XF_0436	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XF_0437	COG0668	transmembrane transport
XF_0442	COG1183	phosphatidylcholine synthase activity
XF_0445	COG0442	prolyl-tRNA aminoacylation
XF_0451	COG0604	alcohol dehydrogenase
XF_0452	COG0330	HflC and HflK could
XF_0453	COG0330	HflC and HflK could
XF_0455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XF_0457	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XF_0458	COG0105	UTP biosynthetic process
XF_0459	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XF_0464	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XF_0465	COG1160	GTP binding
XF_0466	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XF_0470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XF_0472	COG1611	Belongs to the LOG family
XF_0473	COG4968	Prepilin-type N-terminal cleavage methylation domain
XF_0482	COG0629	single-stranded DNA binding
XF_0487	COG4969	Belongs to the N-Me-Phe pilin family
XF_0496	COG2856	Zn peptidase
XF_0501	COG4197	protein conserved in bacteria, prophage-related
XF_0511	COG0740	serine-type endopeptidase activity
XF_0513	COG3772	lysozyme
XF_0523	COG5449	Phage conserved hypothetical protein BR0599
XF_0536	COG0675	Transposase, IS605 OrfB family
XF_0547	COG2878	Part of a membrane complex involved in electron transport
XF_0549	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XF_0549	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XF_0552	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XF_0553	COG3107	peptidoglycan biosynthetic process
XF_0554	COG0792	nuclease activity
XF_0556	COG1162	GTPase activity
XF_0557	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XF_0560	COG0519	Catalyzes the synthesis of GMP from XMP
XF_0560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XF_0563	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XF_0564	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XF_0566	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XF_0568	COG2974	May be involved in recombination
XF_0569	COG0037	tRNA processing
XF_0572	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XF_0576	COG3590	peptidase
XF_0585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XF_0587	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XF_0589	COG0628	permease
XF_0591	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XF_0592	COG3178	'Phosphotransferase
XF_0593	COG1555	photosystem II stabilization
XF_0594	COG1477	protein flavinylation
XF_0598	COG3128	pkhd-type hydroxylase
XF_0599	COG4774	siderophore transport
XF_0603	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XF_0609	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XF_0611	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XF_0615	COG0459	protein refolding
XF_0619	COG1324	tolerance protein
XF_0621	COG0351	phosphomethylpyrimidine kinase
XF_0621	COG0352	thiamine-phosphate diphosphorylase activity
XF_0624	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XF_0647	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XF_0651	COG2311	Membrane
XF_0653	COG0791	NLP P60 protein
XF_0654	COG0791	NLP P60 protein
XF_0656	COG1301	dicarboxylic acid transport
XF_0659	COG0037	tRNA processing
XF_0660	COG1722	exodeoxyribonuclease VII activity
XF_0661	COG0142	geranyltranstransferase activity
XF_0671	COG1028	Short-chain dehydrogenase reductase Sdr
XF_0674	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XF_0675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XF_0707	COG3772	lysozyme
XF_0720	COG3093	addiction module antidote protein HigA
XF_0736	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XF_0737	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XF_0740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XF_0741	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XF_0742	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XF_0742	COG0072	phenylalanine-tRNA ligase activity
XF_0743	COG0776	regulation of translation
XF_0748	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XF_0755	COG1570	exodeoxyribonuclease VII activity
XF_0757	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XF_0757	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XF_0758	COG0802	atpase or kinase
XF_0759	COG0860	N-Acetylmuramoyl-L-alanine amidase
XF_0760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XF_0762	COG0717	Belongs to the dCTP deaminase family
XF_0764	COG0730	response to heat
XF_0765	COG2391	methyltransferase activity
XF_0766	COG2391	methyltransferase activity
XF_0767	COG0640	Transcriptional regulator
XF_0768	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XF_0768	COG3453	Protein conserved in bacteria
XF_0774	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XF_0778	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XF_0778	COG2755	lipolytic protein G-D-S-L family
XF_0783	COG2022	thiamine diphosphate biosynthetic process
XF_0784	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XF_0785	COG3273	potassium ion transport
XF_0785	COG0471	metal ion transport
XF_0789	COG2001	Belongs to the MraZ family
XF_0790	COG0275	rRNA processing
XF_0791	COG3116	cell division
XF_0793	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XF_0794	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XF_0795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XF_0797	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XF_0798	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XF_0799	COG1181	Belongs to the D-alanine--D-alanine ligase family
XF_0800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XF_0802	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XF_0803	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XF_0805	COG0739	heme binding
XF_0806	COG0653	protein targeting
XF_0810	COG4305	rare lipoprotein A
XF_0816	COG0612	Peptidase, M16
XF_0818	COG5297	Belongs to the glycosyl hydrolase family 6
XF_0818	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XF_0821	COG0735	belongs to the Fur family
XF_0822	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XF_0823	COG0126	phosphoglycerate kinase activity
XF_0824	COG0469	pyruvate kinase activity
XF_0826	COG3588	fructose-bisphosphate aldolase
XF_0832	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
XF_0832	COG1648	precorrin-2 dehydrogenase activity
XF_0833	COG0583	DNA-binding transcription factor activity
XF_0834	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XF_0835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XF_0837	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XF_0838	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XF_0839	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XF_0842	COG3537	Alpha-1,2-mannosidase
XF_0845	COG1472	Belongs to the glycosyl hydrolase 3 family
XF_0847	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XF_0848	COG3858	chitin binding
XF_0848	COG1388	LysM domain
XF_0849	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XF_0851	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XF_0852	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XF_0853	COG5002	protein histidine kinase activity
XF_0856	COG1238	metal cluster binding
XF_0857	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XF_0858	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XF_0862	COG0739	heme binding
XF_0863	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XF_0864	COG0626	cystathionine gamma-synthase activity
XF_0868	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XF_0869	COG0508	dehydrogenase complex catalyzes the overall conversion of
XF_0873	COG1464	Belongs to the NlpA lipoprotein family
XF_0874	COG2011	ABC-type metal ion transport system permease component
XF_0875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XF_0880	COG0288	reversible hydration of carbon dioxide
XF_0882	COG1199	ATP-dependent helicase activity
XF_0884	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XF_0889	COG3210	domain, Protein
XF_0901	COG4535	Mg2 and Co2 transporter CorC
XF_0903	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XF_0904	COG1702	phosphate starvation-inducible protein PhoH
XF_0906	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XF_0907	COG0741	lytic transglycosylase activity
XF_0908	COG0723	plastoquinol--plastocyanin reductase activity
XF_0909	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XF_0910	COG2857	Cytochrome c1
XF_0911	COG0625	glutathione transferase activity
XF_0912	COG2969	positive regulation of protein catabolic process
XF_0919	COG0009	L-threonylcarbamoyladenylate synthase
XF_0920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XF_0920	COG1754	DNA topoisomerase type I activity
XF_0923	COG2922	Belongs to the Smg family
XF_0924	COG0758	DNA mediated transformation
XF_0927	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XF_0928	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XF_0928	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XF_0929	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XF_0933	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XF_0933	COG1918	ferrous iron import across plasma membrane
XF_0938	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XF_0939	COG0564	pseudouridine synthase activity
XF_0941	COG3011	Protein conserved in bacteria
XF_0942	COG0579	oxidoreductase
XF_0944	COG0488	(ABC) transporter
XF_0946	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XF_0948	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XF_0950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XF_0950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XF_0954	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XF_0955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XF_0956	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XF_0959	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XF_0960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
XF_0961	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XF_0963	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XF_0967	COG0556	nucleotide-excision repair
XF_0973	COG0784	Response regulator, receiver
XF_0973	COG2205	protein histidine kinase activity
XF_0976	COG1301	dicarboxylic acid transport
XF_0977	COG0280	phosphate acetyltransferase
XF_0977	COG0281	malic enzyme
XF_0978	COG0326	Molecular chaperone. Has ATPase activity
XF_0979	COG0742	ribosomal rna small subunit methyltransferase
XF_0980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XF_0983	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XF_0986	COG3706	GGDEF domain
XF_0988	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XF_0989	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XF_0991	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XF_0994	COG2166	iron-sulfur cluster assembly
XF_0995	COG0215	cysteine-tRNA ligase activity
XF_0998	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XF_0999	COG0137	argininosuccinate synthase activity
XF_1000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XF_1001	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XF_1002	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
XF_1003	COG0165	Argininosuccinate lyase
XF_1004	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XF_1005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XF_1012	COG0590	tRNA wobble adenosine to inosine editing
XF_1013	COG1321	iron dependent repressor
XF_1015	COG1914	H( )-stimulated, divalent metal cation uptake system
XF_1018	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XF_1021	COG1946	Acyl-CoA thioesterase
XF_1031	COG2937	Belongs to the GPAT DAPAT family
XF_1037	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XF_1041	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XF_1042	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XF_1043	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XF_1044	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XF_1045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XF_1047	COG0750	zinc metalloprotease
XF_1048	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XF_1049	COG0575	Belongs to the CDS family
XF_1050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XF_1051	COG0233	cytoplasmic translational termination
XF_1053	COG2067	long-chain fatty acid transport protein
XF_1058	COG0528	UMP kinase activity
XF_1063	COG0363	glucosamine-6-phosphate deaminase activity
XF_1064	COG0837	glucose binding
XF_1065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XF_1067	COG3842	ATPase activity
XF_1068	COG0354	folic acid binding
XF_1070	COG2009	succinate dehydrogenase
XF_1071	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XF_1073	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XF_1074	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XF_1076	COG4591	ABC-type transport system involved in lipoprotein release permease component
XF_1077	COG1136	(ABC) transporter
XF_1079	COG0811	peptide transport
XF_1081	COG1132	(ABC) transporter
XF_1082	COG1663	tetraacyldisaccharide 4'-kinase activity
XF_1087	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XF_1097	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XF_1105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XF_1106	COG0505	Belongs to the CarA family
XF_1107	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XF_1108	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XF_1110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XF_1111	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XF_1112	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XF_1115	COG1024	Enoyl-CoA hydratase
XF_1116	COG0019	diaminopimelate decarboxylase activity
XF_1118	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XF_1120	COG0494	nUDIX hydrolase
XF_1124	COG0424	maF-like protein
XF_1125	COG1530	ribonuclease E activity
XF_1127	COG0312	modulator of DNA gyrase
XF_1130	COG3028	Belongs to the UPF0307 family
XF_1131	COG0312	modulator of DNA gyrase
XF_1132	COG0583	DNA-binding transcription factor activity
XF_1133	COG0655	NAD(P)H dehydrogenase (quinone) activity
XF_1136	COG1064	alcohol dehydrogenase
XF_1140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XF_1142	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XF_1143	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XF_1144	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XF_1145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XF_1146	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XF_1147	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XF_1149	COG0356	it plays a direct role in the translocation of protons across the membrane
XF_1152	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XF_1153	COG0088	Forms part of the polypeptide exit tunnel
XF_1154	COG0089	rRNA binding
XF_1155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XF_1156	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XF_1157	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XF_1158	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XF_1160	COG0255	Belongs to the universal ribosomal protein uL29 family
XF_1161	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XF_1162	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XF_1163	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XF_1164	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XF_1165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XF_1166	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XF_1167	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XF_1168	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XF_1169	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XF_1170	COG1841	ribosomal large subunit assembly
XF_1171	COG0200	Binds to the 23S rRNA
XF_1172	COG0201	protein transport
XF_1173	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XF_1174	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XF_1175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XF_1177	COG0203	ribosomal protein L17
XF_1178	COG2960	long-chain fatty acid transporting porin activity
XF_1179	COG0606	chelatase, subunit chli
XF_1182	COG5380	lipid catabolic process
XF_1183	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XF_1186	COG0544	peptidyl-prolyl cis-trans isomerase activity
XF_1187	COG0740	serine-type endopeptidase activity
XF_1188	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XF_1190	COG0776	regulation of translation
XF_1196	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XF_1197	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XF_1200	COG1187	pseudouridine synthase activity
XF_1209	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XF_1210	COG0625	glutathione transferase activity
XF_1211	COG0039	L-malate dehydrogenase activity
XF_1212	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XF_1222	COG0842	Transport permease protein
XF_1223	COG1131	(ABC) transporter
XF_1229	COG1643	Atp-dependent helicase
XF_1230	COG1956	GAF domain-containing protein
XF_1231	COG0729	surface antigen
XF_1232	COG2911	Protein conserved in bacteria
XF_1252	COG2373	Large extracellular alpha-helical protein
XF_1257	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XF_1258	COG0668	transmembrane transport
XF_1260	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XF_1267	COG5297	Belongs to the glycosyl hydrolase family 6
XF_1269	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XF_1270	COG0321	lipoyl(octanoyl) transferase activity
XF_1271	COG2921	Belongs to the UPF0250 family
XF_1278	COG2733	membrane
XF_1280	COG1253	flavin adenine dinucleotide binding
XF_1288	COG0504	CTP synthase activity
XF_1289	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XF_1291	COG0148	phosphopyruvate hydratase activity
XF_1292	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XF_1293	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XF_1294	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XF_1295	COG2840	Smr protein MutS2
XF_1298	COG0644	oxidoreductase
XF_1298	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XF_1301	COG3218	ABC-type transport auxiliary lipoprotein component
XF_1301	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XF_1302	COG1127	ABC transporter
XF_1303	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XF_1309	COG1077	Cell shape determining protein MreB Mrl
XF_1310	COG1792	Involved in formation and maintenance of cell shape
XF_1311	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XF_1312	COG0768	penicillin binding
XF_1313	COG0772	Belongs to the SEDS family
XF_1314	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XF_1316	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XF_1321	COG2894	cell division
XF_1322	COG0850	regulation of cytokinetic process
XF_1326	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XF_1328	COG3038	cytochrome b561
XF_1329	COG2353	YceI-like domain
XF_1330	COG0784	Response regulator, receiver
XF_1330	COG2198	Histidine kinase
XF_1330	COG2205	protein histidine kinase activity
XF_1332	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XF_1334	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XF_1335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XF_1337	COG0259	pyridoxamine-phosphate oxidase activity
XF_1338	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XF_1341	COG3142	Participates in the control of copper homeostasis
XF_1345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XF_1346	COG4208	sulfate ABC transporter
XF_1347	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XF_1350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XF_1354	COG1846	Transcriptional regulator
XF_1356	COG2267	carboxylic ester hydrolase activity
XF_1357	COG0156	8-amino-7-oxononanoate synthase activity
XF_1360	COG0109	protoheme IX farnesyltransferase activity
XF_1361	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XF_1362	COG0617	tRNA 3'-terminal CCA addition
XF_1363	COG0741	lytic transglycosylase activity
XF_1365	COG0688	phosphatidylethanolamine metabolic process
XF_1368	COG2890	protein-(glutamine-N5) methyltransferase activity
XF_1369	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XF_1371	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XF_1373	COG0101	tRNA pseudouridine synthase activity
XF_1374	COG0135	phosphoribosylanthranilate isomerase activity
XF_1375	COG0133	tryptophan synthase activity
XF_1376	COG0159	tryptophan synthase activity
XF_1379	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XF_1381	COG0514	ATP-dependent DNA helicase (RecQ)
XF_1382	COG0783	Belongs to the Dps family
XF_1383	COG1643	Atp-dependent helicase
XF_1385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XF_1385	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XF_1387	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XF_1388	COG1845	cytochrome c oxidase, subunit III
XF_1389	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XF_1390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XF_1391	COG0142	geranyltranstransferase activity
XF_1392	COG0629	single-stranded DNA binding
XF_1397	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XF_1401	COG2239	Acts as a magnesium transporter
XF_1402	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XF_1403	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XF_1405	COG1660	Displays ATPase and GTPase activities
XF_1409	COG1137	ATPase activity
XF_1412	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XF_1414	COG0271	Belongs to the BolA IbaG family
XF_1415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XF_1423	COG0047	phosphoribosylformylglycinamidine synthase activity
XF_1423	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XF_1424	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XF_1425	COG4974	Belongs to the 'phage' integrase family
XF_1426	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XF_1427	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XF_1430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XF_1437	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XF_1439	COG2915	High frequency lysogenization protein hflD homolog
XF_1440	COG0482	sulfurtransferase activity
XF_1442	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XF_1443	COG0542	response to heat
XF_1445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XF_1446	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XF_1448	COG0492	ferredoxin-NADP+ reductase activity
XF_1450	COG1674	ftsk spoiiie
XF_1452	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XF_1453	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XF_1454	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XF_1455	COG4191	Histidine kinase
XF_1456	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XF_1457	COG1028	Short-chain dehydrogenase reductase Sdr
XF_1460	COG0837	glucose binding
XF_1464	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XF_1465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XF_1468	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XF_1469	COG0726	polysaccharide deacetylase
XF_1470	COG0297	glycogen (starch) synthase activity
XF_1473	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XF_1474	COG0719	Fe-S assembly protein
XF_1475	COG0396	ATPase activity
XF_1476	COG0719	Fe-S assembly protein
XF_1477	COG1959	2 iron, 2 sulfur cluster binding
XF_1481	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XF_1483	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XF_1485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XF_1487	COG2226	methyltransferase
XF_1488	COG0308	aminopeptidase N
XF_1494	COG2912	Transglutaminase-like superfamily
XF_1497	COG0175	sulfate reduction
XF_1498	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XF_1499	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
XF_1500	COG0175	sulfate reduction
XF_1501	COG2895	sulfate adenylyltransferase (ATP) activity
XF_1501	COG0529	Catalyzes the synthesis of activated sulfate
XF_1502	COG1758	RNA polymerase activity
XF_1503	COG0194	GDP metabolic process
XF_1504	COG1561	YicC-like family, N-terminal region
XF_1505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XF_1506	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XF_1507	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XF_1510	COG0596	Alpha beta hydrolase
XF_1512	COG2890	protein-(glutamine-N5) methyltransferase activity
XF_1516	COG5295	Hep Hag repeat protein
XF_1517	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XF_1518	COG1459	type II secretion system
XF_1519	COG2165	general secretion pathway protein
XF_1520	COG4970	Tfp pilus assembly protein FimT
XF_1521	COG2165	general secretion pathway protein
XF_1522	COG4795	General secretion pathway protein
XF_1523	COG3156	type II secretion system protein K
XF_1524	COG3166	PFAM Fimbrial assembly family protein
XF_1527	COG1450	Type ii and iii secretion system protein
XF_1530	COG0450	alkyl hydroperoxide reductase
XF_1531	COG3634	alkyl hydroperoxide reductase activity
XF_1532	COG0583	DNA-binding transcription factor activity
XF_1534	COG0254	rRNA binding
XF_1536	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XF_1537	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XF_1538	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XF_1539	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XF_1545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XF_1550	COG0567	Dehydrogenase, E1 component
XF_1552	COG2850	peptidyl-arginine hydroxylation
XF_1554	COG0114	fumarate hydratase activity
XF_1558	COG0629	single-stranded DNA binding
XF_1564	COG3772	lysozyme
XF_1569	COG5410	chromosome segregation
XF_1571	COG3567	Phage-associated protein, HI1409 family
XF_1574	COG2369	cell adhesion
XF_1589	COG1487	ribonuclease activity
XF_1590	COG4691	Plasmid stability protein
XF_1596	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XF_1597	COG3657	addiction module killer protein
XF_1602	COG1131	(ABC) transporter
XF_1604	COG0386	Belongs to the glutathione peroxidase family
XF_1607	COG2900	Belongs to the SlyX family
XF_1610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XF_1614	COG2027	D-alanyl-D-alanine carboxypeptidase
XF_1617	COG2226	methyltransferase
XF_1623	COG2943	transferase activity, transferring hexosyl groups
XF_1625	COG3275	phosphorelay sensor kinase activity
XF_1627	COG0181	hydroxymethylbilane synthase activity
XF_1638	COG0463	Glycosyl transferase, family 2
XF_1639	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XF_1641	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XF_1641	COG0392	lysyltransferase activity
XF_1642	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XF_1644	COG0629	single-stranded DNA binding
XF_1649	COG5532	Uncharacterized conserved protein (DUF2303)
XF_1666	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XF_1669	COG3772	lysozyme
XF_1674	COG5410	chromosome segregation
XF_1676	COG3567	Phage-associated protein, HI1409 family
XF_1679	COG2369	cell adhesion
XF_1702	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XF_1703	COG3657	addiction module killer protein
XF_1711	COG0251	oxidation-reduction process
XF_1713	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XF_1714	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XF_1715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XF_1716	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XF_1717	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XF_1718	COG0582	viral genome integration into host DNA
XF_1720	COG1396	sequence-specific DNA binding
XF_1722	COG0583	DNA-binding transcription factor activity
XF_1723	COG0667	Aldo Keto reductase
XF_1724	COG0667	Aldo Keto reductase
XF_1725	COG1942	4-Oxalocrotonate Tautomerase
XF_1729	COG0667	Aldo Keto reductase
XF_1730	COG0583	DNA-binding transcription factor activity
XF_1732	COG1902	pentaerythritol trinitrate reductase activity
XF_1734	COG1064	alcohol dehydrogenase
XF_1740	COG2133	pyrroloquinoline quinone binding
XF_1741	COG1028	Short-chain dehydrogenase reductase Sdr
XF_1742	COG3386	PFAM SMP-30 Gluconolaconase
XF_1744	COG4221	oxidoreductase activity
XF_1746	COG1064	alcohol dehydrogenase
XF_1776	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XF_1778	COG0629	single-stranded DNA binding
XF_1785	COG1192	Involved in chromosome partitioning
XF_1791	COG4969	Belongs to the N-Me-Phe pilin family
XF_1795	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XF_1796	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XF_1796	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XF_1800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XF_1801	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XF_1802	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XF_1804	COG0338	D12 class N6 adenine-specific DNA methyltransferase
XF_1808	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XF_1809	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XF_1810	COG0537	adenosine 5'-monophosphoramidase activity
XF_1813	COG0714	Associated with various cellular activities
XF_1815	COG1399	metal-binding, possibly nucleic acid-binding protein
XF_1816	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XF_1817	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XF_1818	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XF_1822	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XF_1825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XF_1827	COG1764	response to oxidative stress
XF_1828	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XF_1833	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XF_1835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XF_1840	COG2353	YceI-like domain
XF_1841	COG1968	undecaprenyl-diphosphatase activity
XF_1842	COG0174	glutamine synthetase
XF_1843	COG0347	Belongs to the P(II) protein family
XF_1844	COG0004	ammonium transporteR
XF_1845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XF_1847	COG4644	lycopene metabolic process
XF_1848	COG2204	response regulator
XF_1849	COG3852	Histidine kinase
XF_1850	COG0675	Transposase, IS605 OrfB family
XF_1856	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XF_1858	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XF_1862	COG2337	Toxic component of a toxin-antitoxin (TA) module
XF_1886	COG0406	alpha-ribazole phosphatase activity
XF_1888	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XF_1890	COG0386	Belongs to the glutathione peroxidase family
XF_1891	COG3104	oligopeptide transport
XF_1892	COG1515	deoxyribonuclease V activity
XF_1893	COG0588	phosphoglycerate mutase activity
XF_1894	COG0602	queuosine metabolic process
XF_1896	COG2885	chlorophyll binding
XF_1897	COG0823	Involved in the tonB-independent uptake of proteins
XF_1901	COG0824	Thioesterase
XF_1902	COG2255	four-way junction helicase activity
XF_1903	COG3158	transport of potassium into the cell
XF_1904	COG0632	four-way junction helicase activity
XF_1905	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XF_1906	COG0217	transcriptional regulatory protein
XF_1908	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XF_1910	COG0552	protein localization to endoplasmic reticulum
XF_1913	COG0084	hydrolase, TatD family'
XF_1920	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XF_1921	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XF_1923	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XF_1924	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XF_1928	COG0745	RESPONSE REGULATOR receiver
XF_1934	COG2091	lysine biosynthetic process via aminoadipic acid
XF_1935	COG0357	Ribosomal RNA small subunit methyltransferase G
XF_1936	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XF_1937	COG1301	dicarboxylic acid transport
XF_1940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XF_1944	COG0339	signal peptide processing
XF_1946	COG0285	dihydrofolate synthase activity
XF_1953	COG0840	transmembrane signaling receptor activity
XF_1956	COG0189	ligase activity
XF_1959	COG0751	glycine-tRNA ligase activity
XF_1960	COG0752	glycyl-tRNA synthetase alpha subunit
XF_1961	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XF_1961	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XF_1965	COG0596	Alpha beta hydrolase
XF_1970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XF_1972	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XF_1975	COG0138	bifunctional purine biosynthesis protein purh
XF_1976	COG0151	Belongs to the GarS family
XF_1978	COG1289	transmembrane transporter activity
XF_1979	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XF_1983	COG0302	gtp cyclohydrolase
XF_1984	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XF_1985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XF_1987	COG0557	exoribonuclease II activity
XF_1990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XF_1992	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XF_1998	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XF_1999	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XF_2009	COG0006	proline dipeptidase activity
XF_2010	COG3079	Belongs to the UPF0149 family
XF_2013	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XF_2015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XF_2019	COG0025	NhaP-type Na H and K H
XF_2022	COG2925	Exonuclease
XF_2028	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XF_2071	COG3609	addiction module antidote protein, CC2985 family
XF_2080	COG3041	Addiction module toxin RelE StbE family
XF_2081	COG3077	Addiction module antitoxin, RelB DinJ family
XF_2082	COG1028	Short-chain dehydrogenase reductase Sdr
XF_2083	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XF_2090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XF_2091	COG2902	Dehydrogenase
XF_2093	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XF_2094	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XF_2095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XF_2096	COG1469	GTP cyclohydrolase I activity
XF_2106	COG0445	tRNA wobble uridine modification
XF_2133	COG0488	(ABC) transporter
XF_2135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XF_2140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XF_2140	COG4651	solute:proton antiporter activity
XF_2141	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XF_2142	COG0573	inorganic phosphate transmembrane transporter activity
XF_2143	COG0581	inorganic phosphate transmembrane transporter activity
XF_2144	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XF_2145	COG0704	Plays a role in the regulation of phosphate uptake
XF_2146	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XF_2148	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XF_2149	COG2967	ApaG domain
XF_2150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XF_2153	COG3642	lipopolysaccharide core region biosynthetic process
XF_2154	COG0859	PFAM glycosyl transferase family 9
XF_2156	COG0631	protein serine/threonine phosphatase activity
XF_2157	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XF_2158	COG0328	RNA-DNA hybrid ribonuclease activity
XF_2160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XF_2165	COG2183	response to ionizing radiation
XF_2171	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XF_2174	COG3118	belongs to the thioredoxin family
XF_2176	COG0495	leucyl-tRNA aminoacylation
XF_2179	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XF_2184	COG2951	lytic endotransglycosylase activity
XF_2196	COG3210	domain, Protein
XF_2201	COG2264	protein methyltransferase activity
XF_2203	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XF_2205	COG0277	FAD linked oxidase domain protein
XF_2206	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XF_2207	COG0531	amino acid
XF_2208	COG0531	amino acid
XF_2209	COG0235	Class ii aldolase
XF_2210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XF_2211	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XF_2213	COG0140	phosphoribosyl-ATP diphosphatase activity
XF_2213	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XF_2214	COG0107	imidazoleglycerol-phosphate synthase activity
XF_2215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XF_2216	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XF_2217	COG0131	Imidazoleglycerol-phosphate dehydratase
XF_2217	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XF_2218	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XF_2219	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XF_2220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XF_2222	COG0124	histidyl-tRNA synthetase
XF_2224	COG0083	homoserine kinase activity
XF_2225	COG0527	aspartate kinase activity
XF_2225	COG0460	homoserine dehydrogenase
XF_2226	COG0540	Belongs to the ATCase OTCase family
XF_2228	COG1678	Uncharacterized ACR, COG1678
XF_2230	COG1686	Belongs to the peptidase S11 family
XF_2232	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XF_2235	COG4953	penicillin-binding protein 1C
XF_2241	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XF_2243	COG0481	GTPase activity
XF_2246	COG0571	ribonuclease III activity
XF_2247	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XF_2248	COG1381	Involved in DNA repair and RecF pathway recombination
XF_2249	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XF_2255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XF_2257	COG1971	Probably functions as a manganese efflux pump
XF_2259	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XF_2260	COG0823	Involved in the tonB-independent uptake of proteins
XF_2260	COG1506	peptidase
XF_2261	COG1297	OPT oligopeptide transporter protein
XF_2268	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XF_2270	COG0676	glucose-6-phosphate 1-epimerase activity
XF_2272	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XF_2273	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XF_2274	COG1335	isochorismatase
XF_2276	COG0318	PFAM AMP-dependent synthetase and ligase
XF_2278	COG0463	Glycosyl transferase, family 2
XF_2281	COG1475	DNA binding
XF_2282	COG1192	Involved in chromosome partitioning
XF_2286	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XF_2298	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XF_2299	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XF_2301	COG0489	protein tyrosine kinase activity
XF_2302	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XF_2303	COG3316	Transposase and inactivated derivatives
XF_2310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XF_2311	COG0322	excinuclease ABC activity
XF_2314	COG3772	lysozyme
XF_2324	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XF_2325	COG0077	Prephenate dehydratase
XF_2325	COG1605	Chorismate mutase
XF_2326	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XF_2328	COG1668	transmembrane transport
XF_2329	COG4555	ABC transporter
XF_2332	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XF_2333	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XF_2334	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XF_2338	COG1605	Chorismate mutase
XF_2338	COG0287	Prephenate dehydrogenase
XF_2339	COG0484	heat shock protein binding
XF_2340	COG0443	Heat shock 70 kDa protein
XF_2341	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XF_2342	COG1420	regulation of RNA biosynthetic process
XF_2343	COG0497	DNA recombination
XF_2345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XF_2346	COG2914	Belongs to the UPF0125 (RnfH) family
XF_2348	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XF_2352	COG1278	Cold shock
XF_2353	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XF_2355	COG1472	Belongs to the glycosyl hydrolase 3 family
XF_2358	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XF_2359	COG0745	RESPONSE REGULATOR receiver
XF_2360	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XF_2364	COG0438	transferase activity, transferring glycosyl groups
XF_2372	COG0473	3-isopropylmalate dehydrogenase activity
XF_2374	COG0066	3-isopropylmalate dehydratase activity
XF_2375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XF_2383	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XF_2383	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XF_2384	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XF_2385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XF_2389	COG1064	alcohol dehydrogenase
XF_2394	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XF_2409	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XF_2409	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XF_2417	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XF_2418	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XF_2419	COG0196	riboflavin kinase activity
XF_2420	COG0728	peptidoglycan biosynthetic process
XF_2421	COG0268	Binds directly to 16S ribosomal RNA
XF_2422	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XF_2423	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XF_2424	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XF_2426	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XF_2429	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XF_2429	COG0519	Catalyzes the synthesis of GMP from XMP
XF_2431	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XF_2432	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XF_2435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XF_2437	COG0776	regulation of translation
XF_2439	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XF_2440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
XF_2446	COG0395	ABC-type sugar transport system, permease component
XF_2447	COG1175	transmembrane transport
XF_2451	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XF_2452	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XF_2453	COG1187	pseudouridine synthase activity
XF_2455	COG4133	protoheme IX ABC transporter activity
XF_2459	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XF_2461	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XF_2465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XF_2470	COG0546	phosphoglycolate phosphatase activity
XF_2471	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XF_2472	COG0402	S-adenosylhomocysteine deaminase activity
XF_2474	COG1509	lysine 2,3-aminomutase activity
XF_2476	COG0483	inositol monophosphate 1-phosphatase activity
XF_2477	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XF_2491	COG2944	sequence-specific DNA binding
XF_2504	COG3772	lysozyme
XF_2524	COG3617	BRO family, N-terminal domain
XF_2530	COG0582	viral genome integration into host DNA
XF_2534	COG0745	RESPONSE REGULATOR receiver
XF_2535	COG0642	Histidine kinase
XF_2536	COG0237	dephospho-CoA kinase activity
XF_2537	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XF_2547	COG0045	succinate-CoA ligase (ADP-forming) activity
XF_2548	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XF_2550	COG2831	hemolysin activation secretion protein
XF_2553	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XF_2555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XF_2556	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XF_2557	COG3115	cell septum assembly
XF_2559	COG0359	binds to the 23S rRNA
XF_2560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XF_2562	COG0316	Belongs to the HesB IscA family
XF_2563	COG0017	Asparaginyl-tRNA synthetase
XF_2571	COG0167	dihydroorotate dehydrogenase activity
XF_2572	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XF_2573	COG0697	spore germination
XF_2574	COG0671	phosphoesterase, PA-phosphatase related
XF_2575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XF_2578	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XF_2579	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XF_2582	COG1132	(ABC) transporter
XF_2585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XF_2586	COG1538	Outer membrane efflux protein
XF_2588	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XF_2591	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XF_2594	COG4783	chaperone-mediated protein folding
XF_2596	COG0473	3-isopropylmalate dehydrogenase activity
XF_2598	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XF_2601	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XF_2603	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XF_2603	COG0316	Belongs to the HesB IscA family
XF_2604	COG2154	pterin-4-alpha-carbinolamine dehydratase
XF_2606	COG0564	pseudouridine synthase activity
XF_2607	COG1530	ribonuclease E activity
XF_2608	COG2197	response regulator
XF_2619	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XF_2622	COG1278	Cold shock
XF_2625	COG0501	Belongs to the peptidase M48B family
XF_2628	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XF_2629	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XF_2630	COG0049	tRNA binding
XF_2631	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XF_2632	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XF_2633	COG0085	RNA polymerase activity
XF_2634	COG0222	ribosome binding
XF_2635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XF_2636	COG0081	regulation of translation
XF_2637	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XF_2638	COG0250	Participates in transcription elongation, termination and antitermination
XF_2639	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XF_2640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XF_2641	COG0012	GTP binding
XF_2642	COG0193	aminoacyl-tRNA hydrolase activity
XF_2643	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XF_2644	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XF_2645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XF_2646	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XF_2648	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XF_2649	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XF_2651	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XF_2651	COG0116	Belongs to the methyltransferase superfamily
XF_2666	COG2095	MarC family integral membrane protein
XF_2669	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XF_2673	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XF_2677	COG2132	Multicopper oxidase
XF_2680	COG0210	DNA helicase
XF_2682	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XF_2685	COG0616	signal peptide processing
XF_2686	COG0534	Mate efflux family protein
XF_2689	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XF_2692	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XF_2694	COG2177	Part of the ABC transporter FtsEX involved in
XF_2695	COG2884	Cell division ATP-binding protein ftsE
XF_2696	COG0513	Belongs to the DEAD box helicase family
XF_2698	COG3118	belongs to the thioredoxin family
XF_2699	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XF_2704	COG0793	Belongs to the peptidase S41A family
XF_2705	COG4942	peptidase
XF_2708	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XF_2709	COG0493	'glutamate synthase
XF_2710	COG0069	glutamate synthase activity
XF_2710	COG0067	glutamate synthase
XF_2710	COG0070	glutamate synthase
XF_2716	COG1028	Short-chain dehydrogenase reductase Sdr
XF_2721	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XF_2730	COG1280	lysine exporter protein (LysE YggA)
XF_2733	COG4942	peptidase
XF_2739	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XF_2742	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XF_2763	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XF_2764	COG3657	addiction module killer protein
XF_2775	COG3210	domain, Protein
XF_2778	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XF_2780	COG0706	membrane insertase activity
XF_2781	COG0594	ribonuclease P activity
XF_a0003	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XF_a0007	COG3451	type IV secretory pathway VirB4
XF_a0012	COG3736	Type IV secretory pathway, component VirB8
XF_a0014	COG2948	multi-organism process
XF_a0019	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XF_a0032	COG0596	Alpha beta hydrolase
XF_a0045	COG3657	addiction module killer protein
XF_a0059	COG1475	DNA binding
XF_a0061	COG0629	single-stranded DNA binding