locus-tag	class	description
XFFB_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFFB_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFFB_00025	COG0187	DNA topoisomerase II activity
XFFB_00035	COG0501	Belongs to the peptidase M48B family
XFFB_00075	COG0408	coproporphyrinogen oxidase activity
XFFB_00095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFFB_00110	COG4969	Belongs to the N-Me-Phe pilin family
XFFB_00140	COG0284	orotidine-5'-phosphate decarboxylase activity
XFFB_00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFFB_00195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFFB_00200	COG0511	ligase activity, forming carbon-carbon bonds
XFFB_00205	COG0439	Biotin carboxylase
XFFB_00210	COG0210	DNA helicase
XFFB_00220	COG1017	nitric oxide dioxygenase activity
XFFB_00220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFFB_00235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFFB_00245	COG1040	competence protein
XFFB_00250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFFB_00255	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFFB_00295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFFB_00305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFFB_00340	COG3121	Chaperone
XFFB_00345	COG3539	Fimbrial protein
XFFB_00350	COG1546	Belongs to the CinA family
XFFB_00355	COG0477	Major facilitator Superfamily
XFFB_00360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFFB_00365	COG1923	regulation of RNA biosynthetic process
XFFB_00370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFFB_00375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFFB_00395	COG1534	Rna-binding protein
XFFB_00405	COG0129	dihydroxy-acid dehydratase activity
XFFB_00430	COG1560	Kdo2-lipid A biosynthetic process
XFFB_00435	COG1519	Transferase
XFFB_00445	COG0228	four-way junction DNA binding
XFFB_00450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFFB_00455	COG0336	Belongs to the RNA methyltransferase TrmD family
XFFB_00460	COG0335	large ribosomal subunit rRNA binding
XFFB_00470	COG2171	N-acyltransferase activity
XFFB_00475	COG1393	Belongs to the ArsC family
XFFB_00480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFFB_00485	COG0367	asparagine synthase
XFFB_00495	COG2070	2-Nitropropane dioxygenase
XFFB_00500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFFB_00505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFFB_00525	COG0339	signal peptide processing
XFFB_00540	COG2132	Multicopper oxidase
XFFB_00570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFFB_00590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFFB_00600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFFB_00605	COG1166	arginine decarboxylase activity
XFFB_00610	COG4221	oxidoreductase activity
XFFB_00620	COG0018	arginyl-trna synthetase
XFFB_00625	COG2003	Belongs to the UPF0758 family
XFFB_00630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFFB_00640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFFB_00650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFFB_00690	COG2223	nitrite transmembrane transporter activity
XFFB_00700	COG0739	heme binding
XFFB_00705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFFB_00735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFFB_00750	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_00755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFFB_00760	COG1272	protein, Hemolysin III
XFFB_00765	COG0463	Glycosyl transferase, family 2
XFFB_00770	COG0084	hydrolase, TatD family'
XFFB_00785	COG0509	glycine decarboxylation via glycine cleavage system
XFFB_00790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFFB_00800	COG0330	HflC and HflK could
XFFB_00805	COG3956	TIGRFAM MazG family protein
XFFB_00810	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFFB_00815	COG0494	nUDIX hydrolase
XFFB_00825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFFB_00830	COG0513	Belongs to the DEAD box helicase family
XFFB_00835	COG0720	synthase
XFFB_00865	COG1981	membrane
XFFB_00870	COG0825	malonyl-CoA metabolic process
XFFB_00875	COG0587	DNA-directed DNA polymerase activity
XFFB_00880	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XFFB_00900	COG0512	Glutamine amidotransferase of anthranilate synthase
XFFB_00905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFFB_00910	COG0134	indole-3-glycerol-phosphate synthase activity
XFFB_00930	COG0006	proline dipeptidase activity
XFFB_00945	COG0343	queuine tRNA-ribosyltransferase activity
XFFB_00955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFFB_00970	COG0617	tRNA 3'-terminal CCA addition
XFFB_00980	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFFB_01010	COG0779	Required for maturation of 30S ribosomal subunits
XFFB_01015	COG0195	Participates in both transcription termination and antitermination
XFFB_01020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFFB_01025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFFB_01040	COG1185	polyribonucleotide nucleotidyltransferase activity
XFFB_01045	COG1733	regulation of RNA biosynthetic process
XFFB_01050	COG0702	epimerase
XFFB_01100	COG2086	electron transfer activity
XFFB_01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFFB_01165	COG0477	Major facilitator Superfamily
XFFB_01180	COG0563	adenylate kinase activity
XFFB_01185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFFB_01190	COG0671	phosphoesterase, PA-phosphatase related
XFFB_01200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFFB_01205	COG0628	permease
XFFB_012100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFFB_012205	COG0629	single-stranded DNA binding
XFFB_012215	COG4962	Type ii secretion system protein e
XFFB_012230	COG3451	type IV secretory pathway VirB4
XFFB_01225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFFB_012290	COG0596	Alpha beta hydrolase
XFFB_01230	COG1090	epimerase
XFFB_01250	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFFB_01270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFFB_01325	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFFB_01335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFFB_01345	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFFB_01355	COG1034	ATP synthesis coupled electron transport
XFFB_01375	COG0713	ATP synthesis coupled electron transport
XFFB_01390	COG1007	ATP synthesis coupled electron transport
XFFB_01395	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_01400	COG2851	Citrate transporter
XFFB_01430	COG0675	Transposase, IS605 OrfB family
XFFB_01460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFFB_01470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFFB_01490	COG0277	FAD linked oxidase domain protein
XFFB_01495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFFB_01505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFFB_01510	COG2124	cytochrome p450
XFFB_01540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFFB_01545	COG0667	Aldo Keto reductase
XFFB_01550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFFB_01585	COG2194	sulfuric ester hydrolase activity
XFFB_01590	COG2124	cytochrome p450
XFFB_01595	COG0352	thiamine-phosphate diphosphorylase activity
XFFB_01645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFFB_01660	COG0494	nUDIX hydrolase
XFFB_01670	COG2193	ferroxidase activity
XFFB_01715	COG0861	Integral membrane protein TerC family
XFFB_01720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFFB_01725	COG0531	amino acid
XFFB_01735	COG1116	anion transmembrane transporter activity
XFFB_01740	COG1322	Protein conserved in bacteria
XFFB_01750	COG2853	Lipoprotein
XFFB_01765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFFB_01770	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFFB_01775	COG1127	ABC transporter
XFFB_01805	COG0358	DNA primase activity
XFFB_01815	COG1610	YqeY-like protein
XFFB_01825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFFB_01830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFFB_01835	COG0668	transmembrane transport
XFFB_01855	COG1183	phosphatidylcholine synthase activity
XFFB_01865	COG0442	prolyl-tRNA aminoacylation
XFFB_01885	COG0604	alcohol dehydrogenase
XFFB_01895	COG0330	HflC and HflK could
XFFB_01905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFFB_01910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFFB_01915	COG0105	UTP biosynthetic process
XFFB_01920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFFB_01940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_01945	COG1160	GTP binding
XFFB_01950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFFB_01955	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFFB_01965	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFFB_02010	COG0629	single-stranded DNA binding
XFFB_02030	COG4969	Belongs to the N-Me-Phe pilin family
XFFB_02140	COG3772	lysozyme
XFFB_02185	COG5449	Phage conserved hypothetical protein BR0599
XFFB_02235	COG0675	Transposase, IS605 OrfB family
XFFB_02275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFFB_02275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFFB_02285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFFB_02290	COG3107	peptidoglycan biosynthetic process
XFFB_02295	COG0792	nuclease activity
XFFB_02300	COG1162	GTPase activity
XFFB_02305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFFB_02315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFFB_02315	COG0519	Catalyzes the synthesis of GMP from XMP
XFFB_02335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFFB_02345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFFB_02355	COG2974	May be involved in recombination
XFFB_02360	COG0037	tRNA processing
XFFB_02370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFFB_02385	COG3590	peptidase
XFFB_02405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFFB_02410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFFB_02420	COG0628	permease
XFFB_02430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFFB_02435	COG3178	'Phosphotransferase
XFFB_02440	COG1555	photosystem II stabilization
XFFB_02445	COG1477	protein flavinylation
XFFB_02465	COG3128	pkhd-type hydroxylase
XFFB_02470	COG4774	siderophore transport
XFFB_02490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFFB_02505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFFB_02515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFFB_02550	COG1324	tolerance protein
XFFB_02560	COG0351	phosphomethylpyrimidine kinase
XFFB_02560	COG0352	thiamine-phosphate diphosphorylase activity
XFFB_02565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFFB_02665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFFB_02675	COG2311	Membrane
XFFB_02685	COG0791	NLP P60 protein
XFFB_02690	COG0791	NLP P60 protein
XFFB_02700	COG1301	dicarboxylic acid transport
XFFB_02710	COG0037	tRNA processing
XFFB_02715	COG1722	exodeoxyribonuclease VII activity
XFFB_02720	COG0142	geranyltranstransferase activity
XFFB_02760	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_02780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFFB_02805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFFB_02810	COG0483	inositol monophosphate 1-phosphatase activity
XFFB_02820	COG1509	lysine 2,3-aminomutase activity
XFFB_02830	COG0402	S-adenosylhomocysteine deaminase activity
XFFB_02835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFFB_02840	COG0546	phosphoglycolate phosphatase activity
XFFB_02875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFFB_02880	COG1138	Cytochrome C-type biogenesis protein
XFFB_02885	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFFB_02900	COG4133	protoheme IX ABC transporter activity
XFFB_02920	COG1187	pseudouridine synthase activity
XFFB_02925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
XFFB_02930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFFB_02950	COG1175	transmembrane transport
XFFB_02955	COG0395	ABC-type sugar transport system, permease component
XFFB_02985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFFB_02995	COG0776	regulation of translation
XFFB_03005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFFB_03020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFFB_03025	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFFB_03035	COG0519	Catalyzes the synthesis of GMP from XMP
XFFB_03035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFFB_03055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFFB_03060	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFFB_03065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFFB_03070	COG0268	Binds directly to 16S ribosomal RNA
XFFB_03075	COG0728	peptidoglycan biosynthetic process
XFFB_03080	COG0196	riboflavin kinase activity
XFFB_03090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFFB_03115	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFFB_03115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFFB_03175	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFFB_03190	COG1064	alcohol dehydrogenase
XFFB_03205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFFB_03210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFFB_03230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFFB_03235	COG0066	3-isopropylmalate dehydratase activity
XFFB_03240	COG0473	3-isopropylmalate dehydrogenase activity
XFFB_03270	COG0438	transferase activity, transferring glycosyl groups
XFFB_03285	COG0438	transferase activity, transferring glycosyl groups
XFFB_03290	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFFB_03295	COG0745	RESPONSE REGULATOR receiver
XFFB_03305	COG2954	triphosphatase activity
XFFB_03315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
XFFB_03320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XFFB_03330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XFFB_03340	COG2914	Belongs to the UPF0125 (RnfH) family
XFFB_03345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_03355	COG0497	DNA recombination
XFFB_03365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFFB_03370	COG0443	Heat shock 70 kDa protein
XFFB_03375	COG0484	heat shock protein binding
XFFB_03380	COG1605	Chorismate mutase
XFFB_03380	COG0287	Prephenate dehydrogenase
XFFB_03390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFFB_03395	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFFB_03400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFFB_03415	COG4555	ABC transporter
XFFB_03420	COG1668	transmembrane transport
XFFB_03430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XFFB_03435	COG1605	Chorismate mutase
XFFB_03435	COG0077	Prephenate dehydratase
XFFB_03440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFFB_03480	COG3772	lysozyme
XFFB_03495	COG0322	excinuclease ABC activity
XFFB_03500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFFB_03540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFFB_03545	COG0489	protein tyrosine kinase activity
XFFB_03550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFFB_03555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFFB_03605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFFB_03615	COG1192	Involved in chromosome partitioning
XFFB_03620	COG1475	DNA binding
XFFB_03630	COG0463	Glycosyl transferase, family 2
XFFB_03640	COG0318	PFAM AMP-dependent synthetase and ligase
XFFB_03650	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFFB_03655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFFB_03660	COG0676	glucose-6-phosphate 1-epimerase activity
XFFB_03670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFFB_03690	COG1297	OPT oligopeptide transporter protein
XFFB_03695	COG1506	peptidase
XFFB_03695	COG0823	Involved in the tonB-independent uptake of proteins
XFFB_03700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_03710	COG1971	Probably functions as a manganese efflux pump
XFFB_03715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFFB_03730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFFB_03735	COG1381	Involved in DNA repair and RecF pathway recombination
XFFB_03740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFFB_03745	COG0571	ribonuclease III activity
XFFB_03760	COG0481	GTPase activity
XFFB_03765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFFB_03815	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFFB_03825	COG1686	Belongs to the peptidase S11 family
XFFB_03830	COG1678	Uncharacterized ACR, COG1678
XFFB_03840	COG0540	Belongs to the ATCase OTCase family
XFFB_03845	COG0460	homoserine dehydrogenase
XFFB_03845	COG0527	aspartate kinase activity
XFFB_03850	COG0083	homoserine kinase activity
XFFB_03860	COG0124	histidyl-tRNA synthetase
XFFB_03870	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFFB_03885	COG0131	Imidazoleglycerol-phosphate dehydratase
XFFB_03885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFFB_03895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFFB_03905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XFFB_03905	COG0140	phosphoribosyl-ATP diphosphatase activity
XFFB_03910	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFFB_03915	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFFB_03920	COG0235	Class ii aldolase
XFFB_03925	COG0531	amino acid
XFFB_03930	COG0531	amino acid
XFFB_03935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFFB_03940	COG0277	FAD linked oxidase domain protein
XFFB_04075	COG2026	Addiction module toxin, RelE StbE family
XFFB_04110	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFFB_04115	COG3657	addiction module killer protein
XFFB_04135	COG1131	(ABC) transporter
XFFB_04140	COG0386	Belongs to the glutathione peroxidase family
XFFB_04155	COG2900	Belongs to the SlyX family
XFFB_04170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFFB_04180	COG2027	D-alanyl-D-alanine carboxypeptidase
XFFB_04195	COG2226	methyltransferase
XFFB_04220	COG3275	phosphorelay sensor kinase activity
XFFB_04230	COG0181	hydroxymethylbilane synthase activity
XFFB_04265	COG0463	Glycosyl transferase, family 2
XFFB_04275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFFB_04290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFFB_04290	COG0392	lysyltransferase activity
XFFB_04295	COG0251	oxidation-reduction process
XFFB_04310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XFFB_04315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFFB_04320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFFB_04325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFFB_04335	COG0582	viral genome integration into host DNA
XFFB_04345	COG1396	sequence-specific DNA binding
XFFB_04355	COG0667	Aldo Keto reductase
XFFB_04360	COG0667	Aldo Keto reductase
XFFB_04365	COG1942	4-Oxalocrotonate Tautomerase
XFFB_04385	COG0583	DNA-binding transcription factor activity
XFFB_04390	COG1902	pentaerythritol trinitrate reductase activity
XFFB_04400	COG1064	alcohol dehydrogenase
XFFB_04430	COG2133	pyrroloquinoline quinone binding
XFFB_04440	COG3386	PFAM SMP-30 Gluconolaconase
XFFB_04450	COG4221	oxidoreductase activity
XFFB_04460	COG1064	alcohol dehydrogenase
XFFB_04625	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFFB_04635	COG0629	single-stranded DNA binding
XFFB_04720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFFB_04725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFFB_04725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFFB_04750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFFB_04770	COG0338	D12 class N6 adenine-specific DNA methyltransferase
XFFB_04795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFFB_04800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XFFB_04805	COG0537	adenosine 5'-monophosphoramidase activity
XFFB_04825	COG0714	Associated with various cellular activities
XFFB_04835	COG1399	metal-binding, possibly nucleic acid-binding protein
XFFB_04840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFFB_04845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFFB_04850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFFB_04870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFFB_04880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFFB_04885	COG1764	response to oxidative stress
XFFB_04890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFFB_04915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFFB_04925	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFFB_04940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFFB_04950	COG0629	single-stranded DNA binding
XFFB_05060	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFFB_05075	COG3772	lysozyme
XFFB_05100	COG5410	chromosome segregation
XFFB_05115	COG2369	cell adhesion
XFFB_05185	COG2026	Addiction module toxin, RelE StbE family
XFFB_05220	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFFB_05225	COG3657	addiction module killer protein
XFFB_05280	COG2353	YceI-like domain
XFFB_05290	COG0174	glutamine synthetase
XFFB_05295	COG0347	Belongs to the P(II) protein family
XFFB_05300	COG0004	ammonium transporteR
XFFB_05305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFFB_05310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFFB_05315	COG2204	response regulator
XFFB_05320	COG3852	Histidine kinase
XFFB_05325	COG0675	Transposase, IS605 OrfB family
XFFB_05350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFFB_05355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFFB_05495	COG0406	alpha-ribazole phosphatase activity
XFFB_05505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
XFFB_05515	COG0386	Belongs to the glutathione peroxidase family
XFFB_05525	COG1515	deoxyribonuclease V activity
XFFB_05530	COG0588	phosphoglycerate mutase activity
XFFB_05535	COG0602	queuosine metabolic process
XFFB_05545	COG2885	chlorophyll binding
XFFB_05550	COG0823	Involved in the tonB-independent uptake of proteins
XFFB_05570	COG0824	Thioesterase
XFFB_05575	COG2255	four-way junction helicase activity
XFFB_05580	COG3158	transport of potassium into the cell
XFFB_05585	COG0632	four-way junction helicase activity
XFFB_05590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFFB_05595	COG0217	transcriptional regulatory protein
XFFB_05600	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFFB_05610	COG0552	protein localization to endoplasmic reticulum
XFFB_05625	COG0084	hydrolase, TatD family'
XFFB_05660	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XFFB_05665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFFB_05675	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFFB_05680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XFFB_05735	COG2091	lysine biosynthetic process via aminoadipic acid
XFFB_05740	COG0357	Ribosomal RNA small subunit methyltransferase G
XFFB_05745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFFB_05750	COG1301	dicarboxylic acid transport
XFFB_05755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFFB_05775	COG0339	signal peptide processing
XFFB_05785	COG0285	dihydrofolate synthase activity
XFFB_05815	COG0643	Histidine kinase
XFFB_05815	COG2198	Histidine kinase
XFFB_05815	COG0784	Response regulator, receiver
XFFB_05820	COG0840	transmembrane signaling receptor activity
XFFB_05835	COG0189	ligase activity
XFFB_05850	COG0751	glycine-tRNA ligase activity
XFFB_05855	COG0752	glycyl-tRNA synthetase alpha subunit
XFFB_05865	COG0727	PFAM Uncharacterised protein family (UPF0153)
XFFB_05885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFFB_05895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFFB_05900	COG0138	bifunctional purine biosynthesis protein purh
XFFB_05905	COG0151	Belongs to the GarS family
XFFB_05915	COG1289	transmembrane transporter activity
XFFB_05920	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFFB_05935	COG0302	gtp cyclohydrolase
XFFB_05940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFFB_05945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFFB_05965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFFB_05970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFFB_06000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFFB_06005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFFB_06045	COG0006	proline dipeptidase activity
XFFB_06050	COG3079	Belongs to the UPF0149 family
XFFB_06070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFFB_06080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFFB_06090	COG0025	NhaP-type Na H and K H
XFFB_06105	COG2925	Exonuclease
XFFB_06210	COG3077	Addiction module antitoxin, RelB DinJ family
XFFB_06215	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_06220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFFB_06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFFB_06255	COG2902	Dehydrogenase
XFFB_06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFFB_06270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFFB_06280	COG1469	GTP cyclohydrolase I activity
XFFB_06300	COG0445	tRNA wobble uridine modification
XFFB_06430	COG0488	(ABC) transporter
XFFB_06440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFFB_06455	COG4651	solute:proton antiporter activity
XFFB_06455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFFB_06460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFFB_06465	COG0573	inorganic phosphate transmembrane transporter activity
XFFB_06470	COG0581	inorganic phosphate transmembrane transporter activity
XFFB_06475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFFB_06480	COG0704	Plays a role in the regulation of phosphate uptake
XFFB_06485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFFB_06490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFFB_06495	COG2967	ApaG domain
XFFB_06500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFFB_06510	COG3642	lipopolysaccharide core region biosynthetic process
XFFB_06515	COG0859	PFAM glycosyl transferase family 9
XFFB_06530	COG0631	protein serine/threonine phosphatase activity
XFFB_06535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFFB_06540	COG0328	RNA-DNA hybrid ribonuclease activity
XFFB_06550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFFB_06555	COG2183	response to ionizing radiation
XFFB_06570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFFB_06575	COG3118	belongs to the thioredoxin family
XFFB_06585	COG0495	leucyl-tRNA aminoacylation
XFFB_06600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFFB_06620	COG2951	lytic endotransglycosylase activity
XFFB_06770	COG0582	viral genome integration into host DNA
XFFB_06780	COG5410	chromosome segregation
XFFB_06805	COG3772	lysozyme
XFFB_06825	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFFB_06880	COG2850	peptidyl-arginine hydroxylation
XFFB_06885	COG0567	Dehydrogenase, E1 component
XFFB_06910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFFB_06940	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFFB_06945	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFFB_06950	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFFB_06970	COG0583	DNA-binding transcription factor activity
XFFB_06975	COG3634	alkyl hydroperoxide reductase activity
XFFB_06990	COG1450	Type ii and iii secretion system protein
XFFB_07005	COG3166	PFAM Fimbrial assembly family protein
XFFB_07010	COG3156	type II secretion system protein K
XFFB_07015	COG4795	General secretion pathway protein
XFFB_07020	COG2165	general secretion pathway protein
XFFB_07025	COG4970	Tfp pilus assembly protein FimT
XFFB_07030	COG2165	general secretion pathway protein
XFFB_07035	COG1459	type II secretion system
XFFB_07040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFFB_07045	COG5295	Hep Hag repeat protein
XFFB_07065	COG2890	protein-(glutamine-N5) methyltransferase activity
XFFB_07070	COG0596	Alpha beta hydrolase
XFFB_07085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFFB_07090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFFB_07100	COG1561	YicC-like family, N-terminal region
XFFB_07105	COG0194	GDP metabolic process
XFFB_07110	COG1758	RNA polymerase activity
XFFB_07120	COG0175	sulfate reduction
XFFB_07130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFFB_07135	COG0175	sulfate reduction
XFFB_07150	COG2912	Transglutaminase-like superfamily
XFFB_07175	COG0308	aminopeptidase N
XFFB_07180	COG2226	methyltransferase
XFFB_07190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFFB_07210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFFB_07225	COG1959	2 iron, 2 sulfur cluster binding
XFFB_07230	COG0719	Fe-S assembly protein
XFFB_07235	COG0396	ATPase activity
XFFB_07245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFFB_07255	COG0297	glycogen (starch) synthase activity
XFFB_07260	COG0726	polysaccharide deacetylase
XFFB_07265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFFB_07270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
XFFB_07275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFFB_07280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFFB_07285	COG1609	Transcriptional regulator
XFFB_07300	COG0837	glucose binding
XFFB_07315	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_07320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFFB_07325	COG4191	Histidine kinase
XFFB_07330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFFB_07335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFFB_07340	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFFB_07350	COG1674	ftsk spoiiie
XFFB_07355	COG0492	ferredoxin-NADP+ reductase activity
XFFB_07365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFFB_07370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFFB_07375	COG0542	response to heat
XFFB_07380	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFFB_07395	COG2915	High frequency lysogenization protein hflD homolog
XFFB_07405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFFB_07425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFFB_07435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XFFB_07440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFFB_07445	COG4974	Belongs to the 'phage' integrase family
XFFB_07450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFFB_07490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFFB_07495	COG0271	Belongs to the BolA IbaG family
XFFB_07505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFFB_07520	COG1137	ATPase activity
XFFB_07540	COG1660	Displays ATPase and GTPase activities
XFFB_07550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFFB_07555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFFB_07575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFFB_07585	COG0142	geranyltranstransferase activity
XFFB_07590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFFB_07595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFFB_07600	COG1845	cytochrome c oxidase, subunit III
XFFB_07605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFFB_07610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFFB_07610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFFB_07630	COG0783	Belongs to the Dps family
XFFB_07635	COG0514	ATP-dependent DNA helicase (RecQ)
XFFB_07645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFFB_07655	COG0159	tryptophan synthase activity
XFFB_07660	COG0133	tryptophan synthase activity
XFFB_07665	COG0135	phosphoribosylanthranilate isomerase activity
XFFB_07670	COG0101	tRNA pseudouridine synthase activity
XFFB_07680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFFB_07685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFFB_07690	COG2890	protein-(glutamine-N5) methyltransferase activity
XFFB_07700	COG0688	phosphatidylethanolamine metabolic process
XFFB_07710	COG0741	lytic transglycosylase activity
XFFB_07715	COG0617	tRNA 3'-terminal CCA addition
XFFB_07725	COG0109	protoheme IX farnesyltransferase activity
XFFB_07735	COG0156	8-amino-7-oxononanoate synthase activity
XFFB_07740	COG2267	carboxylic ester hydrolase activity
XFFB_07750	COG1846	Transcriptional regulator
XFFB_07760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFFB_07770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFFB_07775	COG4208	sulfate ABC transporter
XFFB_07780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFFB_07805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFFB_07810	COG0259	pyridoxamine-phosphate oxidase activity
XFFB_07820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFFB_07825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFFB_07830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFFB_07835	COG2205	protein histidine kinase activity
XFFB_07835	COG2198	Histidine kinase
XFFB_07835	COG0784	Response regulator, receiver
XFFB_07840	COG2353	YceI-like domain
XFFB_07845	COG3038	cytochrome b561
XFFB_07855	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFFB_07875	COG0850	regulation of cytokinetic process
XFFB_07880	COG2894	cell division
XFFB_07900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFFB_07905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFFB_07910	COG0772	Belongs to the SEDS family
XFFB_07915	COG0768	penicillin binding
XFFB_07920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFFB_07930	COG1077	Cell shape determining protein MreB Mrl
XFFB_07970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFFB_07975	COG1127	ABC transporter
XFFB_07980	COG3218	ABC-type transport auxiliary lipoprotein component
XFFB_07980	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFFB_07995	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFFB_07995	COG0644	oxidoreductase
XFFB_08005	COG2840	Smr protein MutS2
XFFB_08010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFFB_08015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFFB_08020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFFB_08025	COG0148	phosphopyruvate hydratase activity
XFFB_08030	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFFB_08035	COG0504	CTP synthase activity
XFFB_08065	COG1253	flavin adenine dinucleotide binding
XFFB_08070	COG2733	membrane
XFFB_08090	COG2921	Belongs to the UPF0250 family
XFFB_08095	COG0321	lipoyl(octanoyl) transferase activity
XFFB_08100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFFB_08105	COG5297	Belongs to the glycosyl hydrolase family 6
XFFB_08125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XFFB_08135	COG0668	transmembrane transport
XFFB_08140	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFFB_08160	COG2373	Large extracellular alpha-helical protein
XFFB_08290	COG0582	viral genome integration into host DNA
XFFB_08305	COG2911	Protein conserved in bacteria
XFFB_08310	COG0729	surface antigen
XFFB_08315	COG1956	GAF domain-containing protein
XFFB_08320	COG1643	Atp-dependent helicase
XFFB_08340	COG1131	(ABC) transporter
XFFB_08345	COG0842	Transport permease protein
XFFB_08375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFFB_08380	COG0039	L-malate dehydrogenase activity
XFFB_08385	COG0625	glutathione transferase activity
XFFB_08390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFFB_08430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFFB_08435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFFB_08475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFFB_08480	COG0740	serine-type endopeptidase activity
XFFB_08485	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFFB_08500	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFFB_08510	COG5380	lipid catabolic process
XFFB_08520	COG0606	chelatase, subunit chli
XFFB_08525	COG2960	long-chain fatty acid transporting porin activity
XFFB_08530	COG0203	ribosomal protein L17
XFFB_08540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFFB_08545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFFB_08550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFFB_08555	COG0201	protein transport
XFFB_08560	COG0200	Binds to the 23S rRNA
XFFB_08565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFFB_08575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFFB_08580	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFFB_08585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
XFFB_08590	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFFB_08595	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFFB_08605	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFFB_08610	COG0255	Belongs to the universal ribosomal protein uL29 family
XFFB_08620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFFB_08625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFFB_08635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFFB_08640	COG0089	rRNA binding
XFFB_08645	COG0088	Forms part of the polypeptide exit tunnel
XFFB_08650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFFB_08660	COG0356	it plays a direct role in the translocation of protons across the membrane
XFFB_08670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFFB_08675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFFB_08680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFFB_08685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFFB_08690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFFB_08695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFFB_08705	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFFB_08720	COG1064	alcohol dehydrogenase
XFFB_08730	COG0655	NAD(P)H dehydrogenase (quinone) activity
XFFB_08735	COG0583	DNA-binding transcription factor activity
XFFB_08745	COG3028	Belongs to the UPF0307 family
XFFB_08750	COG0312	modulator of DNA gyrase
XFFB_08765	COG0424	maF-like protein
XFFB_08780	COG0494	nUDIX hydrolase
XFFB_08800	COG0019	diaminopimelate decarboxylase activity
XFFB_08805	COG1024	Enoyl-CoA hydratase
XFFB_08825	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFFB_08830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFFB_08840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFFB_08850	COG0505	Belongs to the CarA family
XFFB_08855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFFB_08880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFFB_08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFFB_08915	COG1663	tetraacyldisaccharide 4'-kinase activity
XFFB_08920	COG1132	(ABC) transporter
XFFB_08930	COG0811	peptide transport
XFFB_08940	COG1136	(ABC) transporter
XFFB_08945	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFFB_08955	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XFFB_08960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFFB_08970	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFFB_08975	COG2009	succinate dehydrogenase
XFFB_08985	COG0354	folic acid binding
XFFB_08990	COG3842	ATPase activity
XFFB_08995	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFFB_09000	COG0837	glucose binding
XFFB_09005	COG0363	glucosamine-6-phosphate deaminase activity
XFFB_09040	COG0528	UMP kinase activity
XFFB_09065	COG0233	cytoplasmic translational termination
XFFB_09070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFFB_09075	COG0575	Belongs to the CDS family
XFFB_09080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFFB_09085	COG0750	zinc metalloprotease
XFFB_09095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_09100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFFB_09105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_09110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_09115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFFB_09125	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XFFB_09165	COG1946	Acyl-CoA thioesterase
XFFB_09175	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFFB_09180	COG1914	H( )-stimulated, divalent metal cation uptake system
XFFB_09240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFFB_09245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFFB_09250	COG0165	Argininosuccinate lyase
XFFB_09260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFFB_09270	COG0137	argininosuccinate synthase activity
XFFB_09275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFFB_09290	COG2166	iron-sulfur cluster assembly
XFFB_09310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFFB_09315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFFB_09335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFFB_09345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFFB_09350	COG0742	ribosomal rna small subunit methyltransferase
XFFB_09355	COG0326	Molecular chaperone. Has ATPase activity
XFFB_09360	COG0280	phosphate acetyltransferase
XFFB_09360	COG0281	malic enzyme
XFFB_09365	COG1301	dicarboxylic acid transport
XFFB_09380	COG0784	Response regulator, receiver
XFFB_09380	COG2205	protein histidine kinase activity
XFFB_09550	COG5410	chromosome segregation
XFFB_09575	COG3772	lysozyme
XFFB_09595	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFFB_09715	COG5532	Uncharacterized conserved protein (DUF2303)
XFFB_09730	COG3617	BRO family, N-terminal domain
XFFB_09750	COG0629	single-stranded DNA binding
XFFB_09765	COG0556	nucleotide-excision repair
XFFB_09790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFFB_09815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFFB_09820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFFB_09835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFFB_09835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFFB_09840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFFB_09850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFFB_09855	COG0488	(ABC) transporter
XFFB_09860	COG0579	oxidoreductase
XFFB_09865	COG3011	Protein conserved in bacteria
XFFB_09875	COG0564	pseudouridine synthase activity
XFFB_09880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFFB_09900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFFB_09900	COG1918	ferrous iron import across plasma membrane
XFFB_09915	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFFB_09925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFFB_09940	COG0758	DNA mediated transformation
XFFB_09945	COG2922	Belongs to the Smg family
XFFB_09950	COG1754	DNA topoisomerase type I activity
XFFB_09950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFFB_09955	COG0009	L-threonylcarbamoyladenylate synthase
XFFB_09990	COG2969	positive regulation of protein catabolic process
XFFB_09995	COG0625	glutathione transferase activity
XFFB_10000	COG2857	Cytochrome c1
XFFB_10005	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFFB_10010	COG0723	plastoquinol--plastocyanin reductase activity
XFFB_10020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFFB_10025	COG1702	phosphate starvation-inducible protein PhoH
XFFB_10030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFFB_10040	COG4535	Mg2 and Co2 transporter CorC
XFFB_10140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFFB_10160	COG0288	reversible hydration of carbon dioxide
XFFB_10175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFFB_10180	COG2011	ABC-type metal ion transport system permease component
XFFB_10185	COG1464	Belongs to the NlpA lipoprotein family
XFFB_10195	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFFB_10200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFFB_10215	COG0626	cystathionine gamma-synthase activity
XFFB_10220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFFB_10225	COG0739	heme binding
XFFB_10230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFFB_10235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFFB_10240	COG1238	metal cluster binding
XFFB_10255	COG5002	protein histidine kinase activity
XFFB_10260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFFB_10265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFFB_10270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFFB_10275	COG1388	LysM domain
XFFB_10275	COG3858	chitin binding
XFFB_10290	COG1472	Belongs to the glycosyl hydrolase 3 family
XFFB_10315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFFB_10320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFFB_10335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFFB_10340	COG0583	DNA-binding transcription factor activity
XFFB_10375	COG3588	fructose-bisphosphate aldolase
XFFB_10380	COG0469	pyruvate kinase activity
XFFB_10385	COG0126	phosphoglycerate kinase activity
XFFB_10390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFFB_10395	COG0735	belongs to the Fur family
XFFB_10410	COG0612	Peptidase, M16
XFFB_10425	COG4305	rare lipoprotein A
XFFB_10430	COG0653	protein targeting
XFFB_10435	COG0739	heme binding
XFFB_10445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFFB_10450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFFB_10460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFFB_10465	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFFB_10470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFFB_10475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFFB_10485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFFB_10490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFFB_10495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFFB_10505	COG3116	cell division
XFFB_10510	COG0275	rRNA processing
XFFB_10515	COG2001	Belongs to the MraZ family
XFFB_10525	COG0471	metal ion transport
XFFB_10525	COG3273	potassium ion transport
XFFB_10530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFFB_10535	COG2022	thiamine diphosphate biosynthetic process
XFFB_10565	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFFB_10565	COG2755	lipolytic protein G-D-S-L family
XFFB_10590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFFB_10615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFFB_10615	COG3453	Protein conserved in bacteria
XFFB_10620	COG0640	Transcriptional regulator
XFFB_10625	COG2391	methyltransferase activity
XFFB_10630	COG2391	methyltransferase activity
XFFB_10635	COG0730	response to heat
XFFB_10640	COG0717	Belongs to the dCTP deaminase family
XFFB_10650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFFB_10660	COG0802	atpase or kinase
XFFB_10675	COG1570	exodeoxyribonuclease VII activity
XFFB_10700	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFFB_10715	COG0776	regulation of translation
XFFB_10720	COG0072	phenylalanine-tRNA ligase activity
XFFB_10720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFFB_10725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFFB_10730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFFB_10740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFFB_10745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFFB_10820	COG2944	sequence-specific DNA binding
XFFB_11040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFFB_11055	COG0745	RESPONSE REGULATOR receiver
XFFB_11060	COG0642	Histidine kinase
XFFB_11070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFFB_11115	COG0045	succinate-CoA ligase (ADP-forming) activity
XFFB_11120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFFB_11130	COG2831	hemolysin activation secretion protein
XFFB_11145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFFB_11155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFFB_11165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFFB_11170	COG3115	cell septum assembly
XFFB_11180	COG0359	binds to the 23S rRNA
XFFB_11185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFFB_11195	COG0316	Belongs to the HesB IscA family
XFFB_11200	COG0017	Asparaginyl-tRNA synthetase
XFFB_11225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFFB_11230	COG0697	spore germination
XFFB_11240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFFB_11255	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFFB_11260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFFB_11275	COG1132	(ABC) transporter
XFFB_11280	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFFB_11285	COG1538	Outer membrane efflux protein
XFFB_11290	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFFB_11300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFFB_11315	COG4783	chaperone-mediated protein folding
XFFB_11325	COG0473	3-isopropylmalate dehydrogenase activity
XFFB_11335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFFB_11345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFFB_11355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFFB_11355	COG0316	Belongs to the HesB IscA family
XFFB_11360	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFFB_11375	COG1530	ribonuclease E activity
XFFB_11380	COG2197	response regulator
XFFB_11385	COG1054	Belongs to the UPF0176 family
XFFB_11395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFFB_11410	COG0488	(ABC) transporter
XFFB_11415	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFFB_11420	COG1278	Cold shock
XFFB_11430	COG0501	Belongs to the peptidase M48B family
XFFB_11435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFFB_11440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFFB_11445	COG0049	tRNA binding
XFFB_11455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFFB_11460	COG0085	RNA polymerase activity
XFFB_11465	COG0222	ribosome binding
XFFB_11470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFFB_11475	COG0081	regulation of translation
XFFB_11480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFFB_11485	COG0250	Participates in transcription elongation, termination and antitermination
XFFB_11490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFFB_11500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFFB_11520	COG0012	GTP binding
XFFB_11525	COG0193	aminoacyl-tRNA hydrolase activity
XFFB_11545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFFB_11550	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFFB_11560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFFB_11565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFFB_11600	COG2095	MarC family integral membrane protein
XFFB_11605	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFFB_11620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFFB_11630	COG2132	Multicopper oxidase
XFFB_11640	COG0210	DNA helicase
XFFB_11650	COG0616	signal peptide processing
XFFB_11655	COG0534	Mate efflux family protein
XFFB_11670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFFB_11680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFFB_11685	COG2201	protein-glutamate methylesterase activity
XFFB_11690	COG2177	Part of the ABC transporter FtsEX involved in
XFFB_11695	COG2884	Cell division ATP-binding protein ftsE
XFFB_11700	COG0513	Belongs to the DEAD box helicase family
XFFB_11705	COG3118	belongs to the thioredoxin family
XFFB_11710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFFB_11725	COG0793	Belongs to the peptidase S41A family
XFFB_11730	COG4942	peptidase
XFFB_11740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFFB_11745	COG0493	'glutamate synthase
XFFB_11750	COG0067	glutamate synthase
XFFB_11750	COG0069	glutamate synthase activity
XFFB_11750	COG0070	glutamate synthase
XFFB_11780	COG1028	Short-chain dehydrogenase reductase Sdr
XFFB_11805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFFB_11855	COG1280	lysine exporter protein (LysE YggA)
XFFB_11870	COG4942	peptidase
XFFB_11900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFFB_11915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFFB_12015	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFFB_12020	COG3657	addiction module killer protein
XFFB_12075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFFB_12085	COG0706	membrane insertase activity
XFFB_12090	COG0594	ribonuclease P activity