locus-tag	class	description
XFHB_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
XFHB_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
XFHB_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
XFHB_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFHB_00035	ENOG4108K0D	peptidase, M48
XFHB_00075	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
XFHB_00095	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
XFHB_00110	ENOG4108ZUW	Major pilin subunit
XFHB_00140	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
XFHB_00145	ENOG4105CGF	Aromatic amino acid aminotransferase
XFHB_00170	ENOG4105D6S	protein involved in catabolism of external DNA
XFHB_00180	ENOG4108JA2	transcriptioN-repair coupling factor
XFHB_00190	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
XFHB_00195	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
XFHB_00200	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
XFHB_00205	ENOG4105C4R	Atp-dependent dna helicase
XFHB_00215	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
XFHB_00230	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
XFHB_00240	ENOG4105MJ2	Competence protein
XFHB_00245	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
XFHB_00250	ENOG4105D78	K07001 NTE family protein
XFHB_00255	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
XFHB_00290	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
XFHB_00300	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFHB_00330	ENOG4108VEV	chaperone
XFHB_00335	ENOG4105X0I	Fimbrial
XFHB_00340	ENOG4107TH8	cina domain protein
XFHB_00345	ENOG4105CSH	Transporter
XFHB_00350	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
XFHB_00355	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
XFHB_00360	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
XFHB_00365	ENOG4105EEI	dihydropteroate synthase
XFHB_00370	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
XFHB_00375	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
XFHB_00380	ENOG4105HBR	Rna-binding protein
XFHB_00390	ENOG4105C01	Dihydroxy-acid dehydratase
XFHB_00410	ENOG4105D1S	lipid A biosynthesis
XFHB_00415	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
XFHB_00430	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
XFHB_00435	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
XFHB_00440	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
XFHB_00445	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
XFHB_00450	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
XFHB_00455	ENOG4105KUZ	arsenate reductase
XFHB_00460	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
XFHB_00465	ENOG4105CAQ	asparagine synthetase
XFHB_00475	ENOG4105EA8	2-Nitropropane dioxygenase
XFHB_00485	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
XFHB_00505	ENOG4105DGW	oligopeptidase A
XFHB_00530	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
XFHB_00565	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
XFHB_00575	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
XFHB_00585	ENOG4105EMU	Dehydrogenase
XFHB_00600	ENOG4105W5Q	DNA repair protein (RadC
XFHB_00605	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
XFHB_00615	ENOG4107QKV	phosphomannomutase
XFHB_00625	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
XFHB_00650	ENOG4105EYM	Major Facilitator superfamily
XFHB_00655	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
XFHB_00660	ENOG4105DR5	peptidase
XFHB_00665	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
XFHB_00695	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
XFHB_00710	ENOG4105C2D	reductase
XFHB_00715	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
XFHB_00720	ENOG4108UT2	hemolysin iii
XFHB_00730	ENOG4105EYA	deoxyribonuclease
XFHB_00745	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
XFHB_00760	ENOG4107QX8	SPFH domain, Band 7 family protein
XFHB_00765	ENOG4105DXN	mazG family
XFHB_00770	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
XFHB_00775	ENOG4107RK2	ADP-ribose diphosphatase NudE
XFHB_00785	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
XFHB_00790	ENOG4105C1J	atp-dependent rna helicase
XFHB_00795	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
XFHB_00820	ENOG4108YXA	Membrane
XFHB_00830	ENOG4105C0B	DNA polymerase III (alpha subunit)
XFHB_00850	ENOG4105CRQ	synthase (Component I)
XFHB_00855	ENOG4105DDQ	anthranilate synthase
XFHB_00860	ENOG4107QYG	anthranilate phosphoribosyltransferase
XFHB_00865	ENOG4105DK0	Indole-3-glycerol phosphate synthase
XFHB_00885	ENOG4105DC7	peptidase M24
XFHB_00900	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
XFHB_00905	ENOG4105VIE	preprotein translocase, subunit YajC
XFHB_00910	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
XFHB_00915	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
XFHB_00925	ENOG4105DJ0	Poly(A) Polymerase
XFHB_00930	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFHB_00935	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
XFHB_00940	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
XFHB_00945	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
XFHB_00950	ENOG4107QP8	phosphohexose isomerase
XFHB_00965	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
XFHB_00970	ENOG4105CHV	Transcription elongation factor NusA
XFHB_00975	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
XFHB_00980	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
XFHB_00985	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
XFHB_00990	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
XFHB_00995	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
XFHB_01005	ENOG4105ECR	NmrA family
XFHB_01045	ENOG4105C10	Electron transfer flavoprotein
XFHB_01050	ENOG4105BZJ	Electron transfer flavoprotein
XFHB_01065	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
XFHB_01080	ENOG4107QKV	phosphomannomutase
XFHB_01130	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
XFHB_01135	ENOG4105DFU	Cell wall formation (By similarity)
XFHB_01140	ENOG410841Q	phosphoesterase PA-phosphatase related protein
XFHB_01150	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
XFHB_01155	ENOG4105C02	permease
XFHB_01175	ENOG4105C0H	protease
XFHB_01180	ENOG4105ECP	epimerase
XFHB_01185	ENOG4105CEY	Amp-dependent synthetase and ligase
XFHB_01190	ENOG4107QM5	aconitate hydratase
XFHB_01205	ENOG4107QIJ	Aconitate hydratase 2
XFHB_01230	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFHB_01285	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFHB_01295	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFHB_01305	ENOG4105GKE	subunit e
XFHB_01310	ENOG4107QIZ	NADH dehydrogenase
XFHB_01315	ENOG4108IEH	NADH dehydrogenase subunit g
XFHB_01325	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFHB_01330	ENOG4105DF2	NADH dehydrogenase subunit j
XFHB_01335	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFHB_01340	ENOG4105D65	subunit l
XFHB_01345	ENOG4105C8S	subunit m
XFHB_01350	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFHB_01355	ENOG4105CHR	reductase
XFHB_01360	ENOG4105D4T	Citrate transporter
XFHB_01375	ENOG4105DHQ	Histidine kinase
XFHB_01390	ENOG4105D7V	transposase
XFHB_01425	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
XFHB_01430	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFHB_01435	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
XFHB_01445	ENOG4105CDV	Ompa motb domain protein
XFHB_01455	ENOG4105CQB	FAD linked oxidase domain protein
XFHB_01460	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
XFHB_01465	ENOG4105KME	endoribonuclease L-psp
XFHB_01470	ENOG4105CB5	ATP-dependent DNA helicase recG
XFHB_01475	ENOG4106A3M	Cytochrome p-450
XFHB_01485	ENOG4105CDU	Replicative dna helicase
XFHB_01495	ENOG4105CDV	Ompa motb domain protein
XFHB_01500	ENOG4108RVA	ribokinase
XFHB_01505	ENOG4105CPC	Aldo Keto reductase
XFHB_01510	ENOG4108JQC	penicillin-binding protein 1A
XFHB_01535	ENOG4105E4G	Type IV pilus
XFHB_01545	ENOG4105DIJ	Phosphoethanolamine transferase
XFHB_01555	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
XFHB_01565	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
XFHB_01580	ENOG4105UGU	tonB-dependent Receptor
XFHB_01585	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
XFHB_01595	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
XFHB_01600	ENOG4105IFJ	Histidine kinase
XFHB_01605	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
XFHB_01620	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
XFHB_01630	ENOG4108UQY	Iron-storage protein
XFHB_01660	ENOG4105DU1	integral membrane protein, terc
XFHB_01665	ENOG4105DR4	Methyltransferase
XFHB_01670	ENOG4105CUB	amino acid
XFHB_01685	ENOG4107QSV	RmuC domain protein
XFHB_01710	ENOG4107PE3	Mammalian cell entry related domain protein
XFHB_01715	ENOG4105CY3	ABC transporter, permease
XFHB_01720	ENOG4105DHJ	ABC, transporter
XFHB_01730	ENOG4107QKA	exodeoxyribonuclease V beta
XFHB_01745	ENOG4105C31	Tryptophanyl-tRNA synthetase
XFHB_01750	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFHB_01765	ENOG4105VCC	30S ribosomal protein S21
XFHB_01770	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
XFHB_01775	ENOG4107ZVW	dihydroneopterin aldolase
XFHB_01780	ENOG4105CUY	Mechanosensitive ion channel
XFHB_01785	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
XFHB_01800	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
XFHB_01810	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
XFHB_01825	ENOG4105M3Z	response regulator
XFHB_01835	ENOG4107QJR	hflk protein
XFHB_01840	ENOG4105EPW	hflc protein
XFHB_01850	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
XFHB_01855	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
XFHB_01860	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
XFHB_01865	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
XFHB_01885	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFHB_01890	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
XFHB_01895	ENOG4105D06	uba thif-type nad fad binding protein
XFHB_01905	ENOG41066DG	(EAL) domain protein
XFHB_01910	ENOG4105EWT	decarboxylase family
XFHB_01915	ENOG4106855	Competence protein
XFHB_01960	ENOG4108UUM	single-stranded DNA-binding protein
XFHB_02030	ENOG4105M03	Domain of unknown function (DUF955)
XFHB_02045	ENOG410649Z	repressor
XFHB_02050	ENOG4105W7J	DNA binding
XFHB_02115	ENOG4105KUS	lysozyme
XFHB_02205	ENOG4105D7V	transposase
XFHB_02215	ENOG4105X0D	Fimbrial protein
XFHB_02245	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
XFHB_02250	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFHB_02255	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
XFHB_02260	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
XFHB_02270	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
XFHB_02275	ENOG41090JD	Blue (Type 1) copper domain protein
XFHB_02285	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
XFHB_02300	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
XFHB_02315	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
XFHB_02330	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
XFHB_02340	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
XFHB_02355	ENOG4105C9K	Endothelin-converting enzyme 1
XFHB_02375	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
XFHB_02380	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
XFHB_02390	ENOG4105C02	permease
XFHB_02400	ENOG4108S0S	Nucleotidyl transferase
XFHB_02405	ENOG4105EHM	Aminoglycoside phosphotransferase
XFHB_02410	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
XFHB_02415	ENOG4105CJ2	(LipO)protein
XFHB_02435	ENOG4107E2E	PKHD-type hydroxylase
XFHB_02440	ENOG4108IU3	tonb-dependent siderophore receptor
XFHB_02460	ENOG4105C6T	cysteine synthase
XFHB_02475	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
XFHB_02480	ENOG4108DMA	Nad-dependent epimerase dehydratase
XFHB_02510	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
XFHB_02520	ENOG4105VF7	tolerance protein
XFHB_02525	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
XFHB_02530	ENOG4105DWF	phosphomethylpyrimidine kinase
XFHB_02540	ENOG4105E2X	shikimate dehydrogenase
XFHB_02630	ENOG4108V1T	peptidylprolyl cis-trans isomerase
XFHB_02640	ENOG4105CSM	endonuclease III
XFHB_02655	ENOG4108YZY	peptidylprolyl cis-trans isomerase
XFHB_02660	ENOG4105K4H	Nlp p60 protein
XFHB_02665	ENOG4105K4H	Nlp p60 protein
XFHB_02685	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
XFHB_02690	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
XFHB_02695	ENOG4105CTB	Polyprenyl synthetase
XFHB_02715	ENOG4105DDI	hemolysin-type calcium-binding region
XFHB_02720	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
XFHB_02725	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
XFHB_02730	ENOG4105CHR	reductase
XFHB_02740	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFHB_02750	ENOG4105HHA	aminodeoxychorismate lyase
XFHB_02755	ENOG4107QRG	dna polymerase iii
XFHB_02775	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
XFHB_02780	ENOG4105ECY	inositol monophosphatase
XFHB_02790	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
XFHB_02800	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
XFHB_02805	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
XFHB_02810	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
XFHB_02825	ENOG4105DWV	Homoserine O-trans-acetylase
XFHB_02840	ENOG4105KWW	Biogenesis protein
XFHB_02845	ENOG4107QX9	Thiol disulfide interChange protein
XFHB_02850	ENOG4105DA4	cytochrome c-type biogenesis protein
XFHB_02855	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
XFHB_02860	ENOG41060IM	Heme exporter protein
XFHB_02870	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
XFHB_02875	ENOG4105CHM	Aminotransferase
XFHB_02890	ENOG4105FE9	pseudouridine synthase
XFHB_02900	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
XFHB_02920	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
XFHB_02925	ENOG4105DRS	transport system, permease
XFHB_02945	ENOG4105DWY	Agmatine deiminase
XFHB_02955	ENOG4105CAT	Cytidine monophosphate kinase
XFHB_02960	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
XFHB_02965	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
XFHB_02975	ENOG4105CFV	Tetratricopeptide repeat protein
XFHB_02990	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
XFHB_02995	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
XFHB_03000	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
XFHB_03005	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
XFHB_03020	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
XFHB_03025	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
XFHB_03030	ENOG4105K46	50S ribosomal protein l27
XFHB_03035	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFHB_03040	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
XFHB_03045	ENOG4105CJR	Integral membrane protein (MviN
XFHB_03050	ENOG4105DTN	riboflavin biosynthesis protein ribF
XFHB_03055	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
XFHB_03060	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
XFHB_03100	ENOG4105DDI	hemolysin-type calcium-binding region
XFHB_03160	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
XFHB_03165	ENOG4108JJA	ABC, transporter
XFHB_03200	ENOG4105DQ4	alcohol dehydrogenase
XFHB_03215	ENOG4105BZS	acriflavin resistance protein
XFHB_03220	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
XFHB_03225	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
XFHB_03240	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
XFHB_03245	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
XFHB_03250	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
XFHB_03265	ENOG4105D3Q	Sugar transferase
XFHB_03280	ENOG4107UFF	group 1 glycosyl transferase
XFHB_03295	ENOG4108NQK	Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a
XFHB_03300	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
XFHB_03305	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
XFHB_03310	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
XFHB_03315	ENOG41080ZE	Adenylate cyclase
XFHB_03320	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
XFHB_03325	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
XFHB_03335	ENOG4105VEQ	Cold shock protein
XFHB_03345	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
XFHB_03360	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFHB_03365	ENOG41090R7	Ferric uptake
XFHB_03370	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
XFHB_03375	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
XFHB_03390	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
XFHB_03400	ENOG4105ETX	regulatoR
XFHB_03405	ENOG41080IJ	Diacylglycerol kinase
XFHB_03410	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
XFHB_03415	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
XFHB_03430	ENOG4108IUW	ABC transporter
XFHB_03435	ENOG4108SDH	ABC, transporter
XFHB_03455	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
XFHB_03490	ENOG4105KUS	lysozyme
XFHB_03505	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
XFHB_03510	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
XFHB_03530	ENOG4105D52	delta-aminolevulinic acid dehydratase
XFHB_03535	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
XFHB_03550	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
XFHB_03555	ENOG4105D1F	ATP-binding protein
XFHB_03560	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
XFHB_03595	ENOG4105WXW	Antirepressor
XFHB_03720	ENOG4105KUS	lysozyme
XFHB_03790	ENOG41082AG	Plasmid maintenance system antidote protein
XFHB_03800	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
XFHB_03860	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
XFHB_03865	ENOG4105CCU	oxidase (Subunit III)
XFHB_03870	ENOG4105BZ9	Cytochrome C oxidase, subunit I
XFHB_03875	ENOG4105E2S	oxidase) subunit II
XFHB_03880	ENOG4105EAH	synthase
XFHB_03885	ENOG4108UUM	single-stranded DNA-binding protein
XFHB_03890	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
XFHB_03910	ENOG4105CJW	magnesium transporter
XFHB_03915	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
XFHB_03930	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
XFHB_03940	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
XFHB_03945	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
XFHB_03950	ENOG4108IUZ	ABC transporter
XFHB_03965	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
XFHB_03970	ENOG4105C2X	Arabinose 5-phosphate isomerase
XFHB_03980	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
XFHB_04025	ENOG4105T95	Thiol disulfide interChange protein
XFHB_04030	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
XFHB_04035	ENOG4105EYW	Ion transport protein
XFHB_04050	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
XFHB_04065	ENOG4108Z33	Thiol disulfide Interchange Protein
XFHB_04070	ENOG4108Z33	Thiol disulfide Interchange Protein
XFHB_04080	ENOG41075W9	High frequency lysogenization protein HflD homolog
XFHB_04085	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
XFHB_04095	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
XFHB_04100	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
XFHB_04105	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
XFHB_04110	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
XFHB_04120	ENOG4105C3M	thioredoxin reductase
XFHB_04125	ENOG4105CNU	cell division protein FtsK
XFHB_04135	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
XFHB_04140	ENOG4105D1H	recombination factor protein RarA
XFHB_04145	ENOG4105WMR	Protein CrcB homolog
XFHB_04150	ENOG4105BZU	Histidine kinase
XFHB_04160	ENOG410642E	Short chain dehydrogenase
XFHB_04175	ENOG4105CHC	glucokinase (EC 2.7.1.2)
XFHB_04190	ENOG4105ETE	Transcriptional regulator (LacI family
XFHB_04195	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
XFHB_04200	ENOG4105CE4	GlcNAc 6-P deacetylase
XFHB_04205	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
XFHB_04210	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
XFHB_04215	ENOG4107BJW	polysaccharide deacetylase
XFHB_04220	ENOG4107QPH	glycogen) synthase
XFHB_04235	ENOG4105C9B	Cysteine desulfurase
XFHB_04245	ENOG4105C3K	feS assembly ATPase SufC
XFHB_04270	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
XFHB_04280	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
XFHB_04290	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
XFHB_04300	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFHB_04305	ENOG4105CD8	aminopeptidase N
XFHB_04325	ENOG41063JG	Transcriptional regulator
XFHB_04340	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
XFHB_04345	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
XFHB_04355	ENOG4105C11	sulfate adenylyltransferase), subunit 2
XFHB_04360	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
XFHB_04365	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
XFHB_04370	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
XFHB_04375	ENOG4105DSJ	YicC domain protein
XFHB_04385	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
XFHB_04390	ENOG4105CSA	Coproporphyrinogen iii oxidase
XFHB_04405	ENOG4108HGY	Proline imino-peptidase
XFHB_04410	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
XFHB_04425	ENOG4105EUR	Domain-Containing protein
XFHB_04430	ENOG4107QHF	type ii secretion system protein e
XFHB_04435	ENOG4105D7Q	type ii secretion system
XFHB_04445	ENOG4105WMT	general secretion pathway protein h
XFHB_04455	ENOG41069G9	General secretion pathway protein J
XFHB_04460	ENOG4105UV2	general secretion pathway protein K
XFHB_04465	ENOG41090VX	general secretion pathway protein L
XFHB_04470	ENOG410678M	general secretion pathway protein M
XFHB_04480	ENOG4105GVR	general secretion pathway protein D
XFHB_04490	ENOG4105D3R	alkyl hydroperoxide reductase
XFHB_04500	ENOG4105C5Q	Transcriptional regulator
XFHB_04505	ENOG41072GX	Peptidase M22 Glycoprotease
XFHB_04510	ENOG4105NRA	50s ribosomal protein l31 type b
XFHB_04515	ENOG4105BZN	citrate synthase
XFHB_04525	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
XFHB_04530	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
XFHB_04535	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
XFHB_04555	ENOG4105CUZ	uba thif-type nad fad binding protein
XFHB_04575	ENOG4105C7S	Dehydrogenase
XFHB_04580	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
XFHB_04585	ENOG4105EZE	Cupin 4 family protein
XFHB_04590	ENOG4107QTF	adenylosuccinate lyase
XFHB_04600	ENOG4105C9Q	fumarate hydratase class II
XFHB_04605	ENOG4108J6E	Pfam:Phage_integr_N
XFHB_04635	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFHB_04735	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
XFHB_04755	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
XFHB_04760	ENOG4108Z0R	Transferase
XFHB_04765	ENOG4105BZS	acriflavin resistance protein
XFHB_04770	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
XFHB_04780	ENOG4105C7I	Dehydrogenase
XFHB_04825	ENOG4105CHR	reductase
XFHB_04975	ENOG4108C33	Resolvase
XFHB_05110	ENOG4108UUM	single-stranded DNA-binding protein
XFHB_05240	ENOG4105VUH	addiction module killer protein
XFHB_05260	ENOG4108C33	Resolvase
XFHB_05300	ENOG4105CJB	Exodeoxyribonuclease I
XFHB_05315	ENOG4105EEQ	Na H antiporter
XFHB_05325	ENOG4105E66	phosphoriboisomerase A
XFHB_05335	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
XFHB_05340	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
XFHB_05355	ENOG4107RAQ	aminopeptidase
XFHB_05395	ENOG4105CM2	brancheD-chain amino acid aminotransferase
XFHB_05400	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
XFHB_05420	ENOG4106WTF	Glycosyl transferase, family 2
XFHB_05430	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
XFHB_05435	ENOG4107ZT5	Thiol disulfide interchange protein
XFHB_05445	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
XFHB_05455	ENOG4105C2N	RNA methyltransferase TrmH family group 3
XFHB_05460	ENOG4108Z0R	Transferase
XFHB_05465	ENOG4105EUJ	GTP cyclohydrolase i
XFHB_05480	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
XFHB_05485	ENOG4105EM2	membrane
XFHB_05495	ENOG4105C12	Phosphoribosylglycinamide synthetase
XFHB_05500	ENOG4105DC1	bifunctional purine biosynthesis protein purh
XFHB_05510	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
XFHB_05520	ENOG4105E2T	synthase III
XFHB_05540	ENOG4105PI0	Ferredoxin
XFHB_05545	ENOG4105C4K	Nad synthetase
XFHB_05575	ENOG4108UNF	response regulator
XFHB_05580	ENOG4108ZGA	chew protein
XFHB_05585	ENOG4105C8Q	Methyl-accepting chemotaxis
XFHB_05590	ENOG4105CBS	Chea signal transduction histidine kinase
XFHB_05605	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
XFHB_05620	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
XFHB_05630	ENOG4105DGW	oligopeptidase A
XFHB_05645	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
XFHB_05650	ENOG4105CK2	sodium dicarboxylate symporter
XFHB_05655	ENOG4105CV1	Transketolase (EC 2.2.1.1)
XFHB_05660	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
XFHB_05700	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
XFHB_05705	ENOG4108IYU	L-aspartate oxidase
XFHB_05710	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
XFHB_05720	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFHB_05760	ENOG4105F8V	Hydrolase, tatD family
XFHB_05775	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
XFHB_05780	ENOG4105CEN	a g-specific adenine glycosylase
XFHB_05785	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
XFHB_05790	ENOG4105CDY	transcriptional regulatory protein
XFHB_05795	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
XFHB_05800	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
XFHB_05805	ENOG4105DFH	Transport of potassium into the cell (By similarity)
XFHB_05810	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
XFHB_05815	ENOG4107YD3	Thioesterase
XFHB_05820	ENOG4105E02	MotA TolQ exbB proton channel
XFHB_05825	ENOG4105M8F	Biopolymer transport protein exbD tolR
XFHB_05835	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
XFHB_05840	ENOG4105KCK	Peptidoglycan-associated lipoprotein
XFHB_05850	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
XFHB_05855	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
XFHB_05860	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
XFHB_05865	ENOG4105DUX	Transporter
XFHB_05870	ENOG4108V06	Glutathione peroxidase
XFHB_05875	ENOG4105DP0	ferredoxin-NADP reductase
XFHB_05890	ENOG4105CVJ	phosphoglycerate mutase
XFHB_06050	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
XFHB_06055	ENOG4105C9M	aspartyl-trna synthetase
XFHB_06060	ENOG4107GFK	fumarate
XFHB_06085	ENOG4105CUX	Signal transduction histidine kinase
XFHB_06090	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
XFHB_06095	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFHB_06100	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFHB_06105	ENOG4105BZU	Histidine kinase
XFHB_06115	ENOG4105C5F	glutamine synthetase
XFHB_06120	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
XFHB_06145	ENOG4105RKW	reductase (By
XFHB_06155	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
XFHB_06180	ENOG4105D6Z	AFG1 family ATPase
XFHB_06185	ENOG4108ZHJ	Organic hydroperoxide resistance protein
XFHB_06190	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
XFHB_06195	ENOG4105CN1	protease
XFHB_06200	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
XFHB_06215	ENOG4105C7B	Threonine dehydratase
XFHB_06220	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
XFHB_06230	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
XFHB_06235	ENOG4105VGS	50s ribosomal protein l32
XFHB_06240	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
XFHB_06250	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
XFHB_06260	ENOG4105F8C	transglutaminase domain-containing protein
XFHB_06270	ENOG4105K59	histidine triad (HIT) protein
XFHB_06280	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
XFHB_06285	ENOG4107QMP	dna polymerase iii subunits gamma and tau
XFHB_06310	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
XFHB_06315	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
XFHB_06320	ENOG4107YZP	Rhodanese domain protein
XFHB_06345	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
XFHB_06350	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
XFHB_06435	ENOG4105M4H	endoribonuclease L-psp
XFHB_06450	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
XFHB_06455	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
XFHB_06460	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
XFHB_06465	ENOG4105DFA	alanine racemase domain protein
XFHB_06475	ENOG4105DFP	Integrase
XFHB_06490	ENOG4106NZI	LysR family Transcriptional regulator
XFHB_06495	ENOG4105CPC	Aldo Keto reductase
XFHB_06500	ENOG4105CPC	Aldo Keto reductase
XFHB_06505	ENOG4105VW8	4-oxalocrotonate tautomerase
XFHB_06525	ENOG4107S5I	aldo keto reductase
XFHB_06530	ENOG4105HEI	LysR family (Transcriptional regulator
XFHB_06535	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
XFHB_06545	ENOG4105DQ4	alcohol dehydrogenase
XFHB_06550	ENOG4105D8V	Glucose sorbosone dehydrogenase
XFHB_06575	ENOG4105D8V	Glucose sorbosone dehydrogenase
XFHB_06580	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
XFHB_06585	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
XFHB_06595	ENOG4107GJV	short-chain dehydrogenase reductase
XFHB_06600	ENOG4105ENX	hydrolase
XFHB_06605	ENOG4105DQ4	alcohol dehydrogenase
XFHB_06620	ENOG4107RTG	Major Facilitator superfamily
XFHB_06625	ENOG4105ENX	hydrolase
XFHB_06635	ENOG4105EQ2	LysR family Transcriptional regulator
XFHB_06695	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFHB_06700	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
XFHB_06705	ENOG4105BZS	acriflavin resistance protein
XFHB_06710	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
XFHB_06900	ENOG4105EQ2	LysR family Transcriptional regulator
XFHB_06935	ENOG4105NI8	Cytosine-specific methyltransferase
XFHB_06940	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFHB_06945	ENOG4107YH6	single-stranded DNA-binding protein
XFHB_06980	ENOG4107QJE	Chromosome Partitioning Protein
XFHB_07025	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
XFHB_07030	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
XFHB_07055	ENOG4106FAK	Endodeoxyribonuclease RusA
XFHB_07190	ENOG4108UUM	single-stranded DNA-binding protein
XFHB_07200	ENOG4108J6E	Pfam:Phage_integr_N
XFHB_07220	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFHB_07230	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
XFHB_07240	ENOG4105CZX	twitching motility protein
XFHB_07245	ENOG4105CZX	twitching motility protein
XFHB_07260	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
XFHB_07265	ENOG4108NEV	two component transcriptional regulator, LytTR family
XFHB_07270	ENOG4108HRK	Histidine kinase
XFHB_07280	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
XFHB_07295	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFHB_07310	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
XFHB_07320	ENOG4105D7K	pfkb domain protein
XFHB_07340	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
XFHB_07350	ENOG4108V06	Glutathione peroxidase
XFHB_07360	ENOG4105CZV	ABC transporter
XFHB_07380	ENOG4105VUH	addiction module killer protein
XFHB_07385	ENOG4105YES	addiction module antidote protein
XFHB_07400	ENOG4105D4Y	metalloprotease
XFHB_07480	ENOG4106GZK	Protein of unknown function (DUF2669)
XFHB_07500	ENOG4106GMR	
XFHB_07535	ENOG4108C66	Inherit from COG: DNA primase
XFHB_07570	ENOG4105KUS	lysozyme
XFHB_07590	ENOG4106FAK	Endodeoxyribonuclease RusA
XFHB_07725	ENOG4108UUM	single-stranded DNA-binding protein
XFHB_07735	ENOG4108J6E	Pfam:Phage_integr_N
XFHB_07755	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFHB_07765	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
XFHB_07775	ENOG4105CZX	twitching motility protein
XFHB_07780	ENOG4105CZX	twitching motility protein
XFHB_07795	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
XFHB_07800	ENOG4108NEV	two component transcriptional regulator, LytTR family
XFHB_07805	ENOG4108HRK	Histidine kinase
XFHB_07815	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
XFHB_07830	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFHB_07845	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
XFHB_07855	ENOG4105D7K	pfkb domain protein
XFHB_07875	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
XFHB_07885	ENOG4108V06	Glutathione peroxidase
XFHB_07895	ENOG4105CZV	ABC transporter
XFHB_07915	ENOG4105VUH	addiction module killer protein
XFHB_07920	ENOG4105YES	addiction module antidote protein
XFHB_07935	ENOG4105D4Y	metalloprotease
XFHB_08015	ENOG4106GZK	Protein of unknown function (DUF2669)
XFHB_08035	ENOG4106GMR	
XFHB_08070	ENOG4108C66	Inherit from COG: DNA primase
XFHB_08115	ENOG4105KUS	lysozyme
XFHB_08160	ENOG4108UUM	single-stranded DNA-binding protein
XFHB_08170	ENOG4105C5H	ABC transporter
XFHB_08175	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFHB_08180	ENOG4107ZXU	DSBA oxidoreductase
XFHB_08185	ENOG4107RNH	Outer membrane receptor FepA
XFHB_08190	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
XFHB_08195	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
XFHB_08200	ENOG4105C8U	phosphate abc transporter
XFHB_08205	ENOG4105E2Z	phosphate ABC transporter (Permease
XFHB_08210	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
XFHB_08215	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
XFHB_08220	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
XFHB_08225	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
XFHB_08230	ENOG4105NWN	ApaG protein
XFHB_08235	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
XFHB_08245	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
XFHB_08250	ENOG4105DKP	glycosyl transferase, family 9
XFHB_08265	ENOG4108ZF3	Phosphatase
XFHB_08270	ENOG4107RZZ	dna polymerase iii epsilon subunit
XFHB_08275	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
XFHB_08285	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
XFHB_08290	ENOG4105BZM	domain protein
XFHB_08305	ENOG4105F0N	pyrophosphate phospho-hydrolase
XFHB_08310	ENOG4105K63	Thioredoxin
XFHB_08320	ENOG4105C8T	Leucyl-tRNA synthetase
XFHB_08335	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
XFHB_08360	ENOG4105CVE	Lytic murein transglycosylase
XFHB_08365	ENOG4105K6T	rare lipoprotein A
XFHB_08470	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
XFHB_08480	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
XFHB_08485	ENOG4105CQB	FAD linked oxidase domain protein
XFHB_08490	ENOG4108JQ1	Dehydrogenase
XFHB_08495	ENOG4105CUB	amino acid
XFHB_08500	ENOG4105CUB	amino acid
XFHB_08505	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
XFHB_08510	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
XFHB_08515	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
XFHB_08520	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
XFHB_08540	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
XFHB_08550	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
XFHB_08555	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
XFHB_08565	ENOG4105CUT	histidyl-tRNA synthetase
XFHB_08575	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
XFHB_08580	ENOG4105CFH	Aspartokinase
XFHB_08585	ENOG4105CXT	aspartate transcarbamylase
XFHB_08595	ENOG4108UJU	UPF0301 protein
XFHB_08600	ENOG4105DZ1	carboxypeptidase
XFHB_08610	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
XFHB_08625	ENOG4108JQB	penicillin-binding protein 1C
XFHB_08645	ENOG4105EMN	RNA polymerase sigma factor
XFHB_08655	ENOG4105C0H	protease
XFHB_08660	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
XFHB_08665	ENOG4105C3F	Signal peptidase i
XFHB_08675	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
XFHB_08680	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
XFHB_08690	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
XFHB_08695	ENOG4107QN1	sodium solute
XFHB_08705	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
XFHB_08725	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
XFHB_08730	ENOG4105EPD	Oligopeptide transporter, Opt family
XFHB_08740	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
XFHB_08745	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
XFHB_08750	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
XFHB_08760	ENOG4105DSB	aldose 1-epimerase
XFHB_08765	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
XFHB_08770	ENOG4105WPN	DNA integration recombination invertion protein
XFHB_08780	ENOG410680H	amp-dependent synthetase and ligase
XFHB_08800	ENOG4105FA0	parb-like partition protein
XFHB_08805	ENOG4107QJE	Chromosome Partitioning Protein
XFHB_08815	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
XFHB_08870	ENOG4105CQ7	ATP-dependent helicase
XFHB_08890	ENOG4108M8W	Monooxygenase
XFHB_08895	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
XFHB_08925	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
XFHB_08935	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
XFHB_08940	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
XFHB_08960	ENOG4107SC1	transglycosylase
XFHB_08965	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
XFHB_08970	ENOG4107U32	Beta-lactamase domain protein
XFHB_08985	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
XFHB_08990	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
XFHB_09000	ENOG4105NTK	Transcriptional repressor Mpra
XFHB_09005	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFHB_09010	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
XFHB_09020	ENOG4108IJ6	ABC transporter
XFHB_09030	ENOG4108I5D	sulfate abc transporter
XFHB_09035	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
XFHB_09045	ENOG4106N3A	copper homeostasis protein cutc
XFHB_09050	ENOG4105CX6	glutaminyL-tRNA synthetase
XFHB_09055	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
XFHB_09065	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
XFHB_09070	ENOG4105D49	3-dehydroquinate synthase
XFHB_09075	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
XFHB_09085	ENOG4108YYC	ycei family
XFHB_09090	ENOG4108VKM	cytochrome b561
XFHB_09125	ENOG4107QMS	site-determining protein
XFHB_09145	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
XFHB_09150	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
XFHB_09155	ENOG4105CNI	cell division protein FtsW
XFHB_09160	ENOG4105CJN	penicillin-binding protein
XFHB_09175	ENOG4105DFF	Rod shape-determining protein mreb
XFHB_09205	ENOG4105DHJ	ABC, transporter
XFHB_09210	ENOG4108SNX	Mammalian cell entry related domain protein
XFHB_09225	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
XFHB_09235	ENOG4108DG9	Smr protein MutS2
XFHB_09240	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
XFHB_09245	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
XFHB_09250	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
XFHB_09255	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
XFHB_09260	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
XFHB_09265	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
XFHB_09275	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFHB_09300	ENOG4106BRA	Membrane
XFHB_09325	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
XFHB_09330	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
XFHB_09335	ENOG41065HY	1,4-beta-cellobiosidase
XFHB_09370	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
XFHB_09390	ENOG4105DN3	alpha-2-macroglobulin domain protein
XFHB_09400	ENOG4105C7F	AcnD-accessory protein PrpF
XFHB_09405	ENOG4108I0Z	Aconitate hydratase
XFHB_09500	ENOG4105CR4	methylisocitrate lyase
XFHB_09505	ENOG4105MA0	exported protein
XFHB_09510	ENOG4105CFU	surface antigen
XFHB_09520	ENOG4105CQ7	ATP-dependent helicase
XFHB_09540	ENOG4105DA5	(ABC) transporter
XFHB_09545	ENOG4105E3A	(ABC) transporter
XFHB_09550	ENOG4108JJA	ABC, transporter
XFHB_09560	ENOG4108MBX	Secretion Protein
XFHB_09570	ENOG4105CI3	gtp-binding protein typa
XFHB_09575	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
XFHB_09580	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
XFHB_09585	ENOG4108K3A	Glutathione S-transferase
XFHB_09590	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
XFHB_09620	ENOG4105I08	Pseudouridine synthase
XFHB_09635	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
XFHB_09640	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
XFHB_09655	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
XFHB_09670	ENOG4105K70	DNA-binding protein
XFHB_09680	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
XFHB_09685	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
XFHB_09690	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
XFHB_09705	ENOG4107QQG	Dehydrogenase
XFHB_09715	ENOG4105MGK	May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity)
XFHB_09725	ENOG4105C0P	Mg chelatase subunit ChlI
XFHB_09730	ENOG4105W0Z	cytoplasmic protein
XFHB_09735	ENOG4108ZT0	50S ribosomal protein l17
XFHB_09745	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
XFHB_09750	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
XFHB_09755	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFHB_09760	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
XFHB_09765	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
XFHB_09770	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
XFHB_09775	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
XFHB_09780	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
XFHB_09785	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
XFHB_09790	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFHB_09795	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
XFHB_09800	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
XFHB_09805	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
XFHB_09810	ENOG41083MP	50s ribosomal protein l29
XFHB_09820	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
XFHB_09825	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
XFHB_09830	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFHB_09835	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
XFHB_09840	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
XFHB_09850	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
XFHB_09855	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFHB_09860	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFHB_09865	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFHB_09870	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
XFHB_09875	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
XFHB_09880	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
XFHB_09885	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
XFHB_09895	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
XFHB_09910	ENOG4105DQ4	alcohol dehydrogenase
XFHB_09925	ENOG4105CC0	LysR family Transcriptional regulator
XFHB_09930	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
XFHB_09935	ENOG4105N42	UPF0307 protein
XFHB_09940	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
XFHB_09950	ENOG4105C03	ribonuclease
XFHB_09955	ENOG4108Z03	MAF-like protein
XFHB_09965	ENOG4105SYT	Methylenetetrahydrofolate reductase
XFHB_09970	ENOG4105M6F	mutator MutT protein
XFHB_09980	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
XFHB_09995	ENOG4105E39	Enoyl-CoA hydratase
XFHB_10000	ENOG4105BZU	Histidine kinase
XFHB_10005	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
XFHB_10010	ENOG4105CRK	lysyL-tRNA synthetase
XFHB_10015	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
XFHB_10020	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
XFHB_10030	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
XFHB_10035	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
XFHB_10040	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
XFHB_10045	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
XFHB_10055	ENOG4105C2M	dna polymerase I
XFHB_10070	ENOG4107RH7	Nicotinate phosphoribosyltransferase
XFHB_10075	ENOG4105CS1	NAD(P)H quinone oxidoreductase
XFHB_10085	ENOG4107RZC	phospholipase d
XFHB_10105	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
XFHB_10110	ENOG4105BZ1	(ABC) transporter
XFHB_10125	ENOG4108EC8	DNA internalization-related competence protein ComEC
XFHB_10130	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
XFHB_10180	ENOG4108IJ9	(ABC) transporter
XFHB_10185	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
XFHB_10190	ENOG4105CHC	glucokinase (EC 2.7.1.2)
XFHB_10195	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
XFHB_10200	ENOG4105C01	Dihydroxy-acid dehydratase
XFHB_10205	ENOG4108UHU	Aldolase
XFHB_10230	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
XFHB_10250	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
XFHB_10255	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
XFHB_10260	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
XFHB_10265	ENOG4105KNE	Phosphatidate cytidylyltransferase
XFHB_10275	ENOG4105DZP	Membrane-associated zinc metalloprotease
XFHB_10280	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFHB_10285	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFHB_10290	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
XFHB_10295	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFHB_10300	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFHB_10305	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
XFHB_10355	ENOG4105C29	acyl-CoA thioesterase
XFHB_10365	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
XFHB_10370	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
XFHB_10375	ENOG4105KST	dependent repressor
XFHB_10380	ENOG4108Z6B	deaminase
XFHB_10385	ENOG4105DDI	hemolysin-type calcium-binding region
XFHB_10415	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
XFHB_10420	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
XFHB_10425	ENOG4105CH7	arginosuccinase
XFHB_10430	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
XFHB_10435	ENOG4105CAS	nag kinase
XFHB_10445	ENOG4105CDH	Citrulline--aspartate ligase
XFHB_10450	ENOG4105DBV	ornithine carbamoyltransferase
XFHB_10460	ENOG4105C8N	cysteinyl-tRNA synthetase
XFHB_10465	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
XFHB_10470	ENOG4105E8G	Major facilitator Superfamily
XFHB_10480	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XFHB_10485	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
XFHB_10490	ENOG4105CD3	dihydroorotase
XFHB_10500	ENOG4105BZU	Histidine kinase
XFHB_10510	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
XFHB_10520	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
XFHB_10525	ENOG4106H78	methyltransferase
XFHB_10530	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
XFHB_10535	ENOG4105C6K	Malic enzyme
XFHB_10540	ENOG4105CK2	sodium dicarboxylate symporter
XFHB_10585	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
XFHB_10610	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFHB_10615	ENOG4108IAB	Phoh family
XFHB_10620	ENOG4108IAB	Phoh family
XFHB_10635	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
XFHB_10640	ENOG4107YIM	Involved in the transcription termination process (By similarity)
XFHB_10650	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
XFHB_10660	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
XFHB_10665	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
XFHB_10675	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
XFHB_10680	ENOG4105C5H	ABC transporter
XFHB_10685	ENOG4105DWT	malate dehydrogenase (quinone)
XFHB_10690	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
XFHB_10695	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
XFHB_10700	ENOG4105C34	Pseudouridine synthase
XFHB_10705	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFHB_10715	ENOG4105CE1	Ferrous iron transport protein b
XFHB_10730	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
XFHB_10740	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
XFHB_10755	ENOG4105C79	DNA protecting protein DprA
XFHB_10760	ENOG4108RPN	Protein smg homolog
XFHB_10770	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFHB_10775	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
XFHB_10805	ENOG4105KB2	stringent starvation protein b
XFHB_10810	ENOG4107MKT	Stringent starvation protein a
XFHB_10815	ENOG4105EIX	cytochrome c1
XFHB_10820	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
XFHB_10825	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
XFHB_10835	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
XFHB_10840	ENOG4105C9A	Phoh family
XFHB_10845	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
XFHB_10855	ENOG4108JU5	Magnesium and cobalt efflux protein
XFHB_10950	ENOG4105BZ4	penicillin-binding protein
XFHB_10960	ENOG4105DVT	helicase
XFHB_10970	ENOG41077A9	carbonic anhydrase
XFHB_10990	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
XFHB_10995	ENOG4108UMI	ABC transporter, permease
XFHB_11000	ENOG4105D01	(LipO)protein
XFHB_11010	ENOG4107QSN	dihydrolipoamide acetyltransferase
XFHB_11015	ENOG4107QN2	dihydrolipoyl dehydrogenase
XFHB_11030	ENOG4105C28	cystathionine
XFHB_11035	ENOG4106TYC	homoserine o-acetyltransferase (EC 2.3.1.31)
XFHB_11040	ENOG4105DR5	peptidase
XFHB_11045	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
XFHB_11050	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
XFHB_11055	ENOG4108UM1	dedA family
XFHB_11060	ENOG4108K5P	(LipO)protein
XFHB_11070	ENOG4105BZU	Histidine kinase
XFHB_11075	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
XFHB_11080	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
XFHB_11085	ENOG4105E0X	reductase
XFHB_11090	ENOG4105VRS	hydrolase family 18
XFHB_11095	ENOG4105E2D	ec 3.2.1.52
XFHB_11120	ENOG4105CWX	Alpha-1,2-mannosidase
XFHB_11130	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
XFHB_11135	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
XFHB_11140	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
XFHB_11145	ENOG4105D0A	hydroxylase
XFHB_11150	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
XFHB_11155	ENOG4107R11	Transcriptional regulator
XFHB_11185	ENOG4107R1Y	fructose-bisphosphate aldolase
XFHB_11190	ENOG4105CA9	Pyruvate kinase
XFHB_11195	ENOG4105BZA	Phosphoglycerate kinase
XFHB_11200	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
XFHB_11205	ENOG4105MYN	Zinc uptake regulation protein
XFHB_11215	ENOG4106R7G	Glycoside hydrolase family 5
XFHB_11240	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
XFHB_11245	ENOG4105DR5	peptidase
XFHB_11255	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFHB_11260	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
XFHB_11265	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
XFHB_11270	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
XFHB_11275	ENOG4105CPF	Cell wall formation (By similarity)
XFHB_11280	ENOG4105DFU	Cell wall formation (By similarity)
XFHB_11285	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
XFHB_11295	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
XFHB_11300	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
XFHB_11305	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
XFHB_11310	ENOG4105CJN	penicillin-binding protein
XFHB_11315	ENOG4106932	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
XFHB_11320	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
XFHB_11340	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
XFHB_11345	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
XFHB_11350	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
XFHB_11375	ENOG4105EXC	Acyl-transferase
XFHB_11405	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
XFHB_11430	ENOG4107QPB	Beta-lactamase domain protein
XFHB_11435	ENOG41080HT	Transcriptional regulator, arsr family
XFHB_11440	ENOG4105MD1	YeeE YedE family protein
XFHB_11445	ENOG4105KFG	YeeE YedE family protein
XFHB_11450	ENOG4108VCT	Sulfite exporter TauE/SafE
XFHB_11455	ENOG4105DHP	deoxycytidine triphosphate deaminase
XFHB_11465	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
XFHB_11470	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
XFHB_11475	ENOG4105K8N	protein family UPF0079, ATPase
XFHB_11480	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
XFHB_11490	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
XFHB_11515	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
XFHB_11530	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
XFHB_11535	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
XFHB_11540	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
XFHB_11545	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
XFHB_11555	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
XFHB_11560	ENOG4105C22	threonyL-tRNA synthetase
XFHB_11705	ENOG4105KUS	lysozyme
XFHB_11810	ENOG4105WXW	Antirepressor
XFHB_11855	ENOG4105ETX	regulatoR
XFHB_11865	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
XFHB_11870	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
XFHB_11900	ENOG4107QHF	type ii secretion system protein e
XFHB_11905	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
XFHB_11910	ENOG4107TUY	Histidine kinase
XFHB_11920	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
XFHB_11930	ENOG4105D5K	Hemolysin activator protein
XFHB_11940	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFHB_11955	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
XFHB_11965	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
XFHB_11970	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
XFHB_11980	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
XFHB_11985	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
XFHB_11995	ENOG4108Z4V	iron-sulfur cluster assembly
XFHB_12000	ENOG4105C5S	asparaginyl-tRNA synthetase
XFHB_12025	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
XFHB_12030	ENOG4105D4A	Cell wall formation (By similarity)
XFHB_12035	ENOG4108SXK	Transporter Drug Metabolite Exporter family
XFHB_12040	ENOG410841Q	phosphoesterase PA-phosphatase related protein
XFHB_12045	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
XFHB_12055	ENOG4108UYB	regulatoR
XFHB_12060	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
XFHB_12075	ENOG4105BZ1	(ABC) transporter
XFHB_12080	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
XFHB_12085	ENOG4105DFG	type I secretion outer membrane protein
XFHB_12090	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
XFHB_12095	ENOG4105C9X	ppx gppa phosphatase
XFHB_12100	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
XFHB_12105	ENOG4105BZU	Histidine kinase
XFHB_12110	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
XFHB_12115	ENOG4105ERG	peptidase m48, ste24p
XFHB_12120	ENOG4105VW4	glutaredoxin 3
XFHB_12125	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
XFHB_12135	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
XFHB_12145	ENOG4108Z4U	Ferredoxin
XFHB_12155	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
XFHB_12160	ENOG41090A4	Pterin carbinolamine dehydratase
XFHB_12170	ENOG4105EI2	Pseudouridine synthase
XFHB_12175	ENOG4105C03	ribonuclease
XFHB_12185	ENOG4105C72	UPF0176 protein
XFHB_12195	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFHB_12210	ENOG4105C5H	ABC transporter
XFHB_12215	ENOG4105CNG	UPF0061 protein
XFHB_12230	ENOG4105D0M	Protease HtpX homolog
XFHB_12235	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
XFHB_12240	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
XFHB_12245	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
XFHB_12250	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
XFHB_12255	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
XFHB_12260	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
XFHB_12265	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
XFHB_12270	ENOG4108VZM	50s ribosomal protein L10
XFHB_12275	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
XFHB_12280	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
XFHB_12285	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
XFHB_12290	ENOG4105PM1	preprotein translocase subunit SecE
XFHB_12300	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
XFHB_12320	ENOG4105C3G	gtp-binding protein
XFHB_12325	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
XFHB_12335	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
XFHB_12345	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
XFHB_12350	ENOG4108D76	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
XFHB_12355	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
XFHB_12360	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
XFHB_12365	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
XFHB_12370	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
XFHB_12415	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
XFHB_12420	ENOG4105M2J	Glutaredoxin
XFHB_12425	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
XFHB_12430	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
XFHB_12435	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
XFHB_12455	ENOG4105C4R	Atp-dependent dna helicase
XFHB_12460	ENOG4105DJ9	glucan biosynthesis protein
XFHB_12465	ENOG4105D07	Signal peptide peptidase, SppA
XFHB_12470	ENOG4107QI1	Mate efflux family protein
XFHB_12490	ENOG4105C25	Primosomal protein n'
XFHB_12500	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
XFHB_12505	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
XFHB_12510	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
XFHB_12515	ENOG4105CAK	Cell division ATP-binding protein ftsE
XFHB_12520	ENOG4105C1J	atp-dependent rna helicase
XFHB_12525	ENOG4105K63	Thioredoxin
XFHB_12530	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
XFHB_12535	ENOG4105E9K	Isocitrate dehydrogenase
XFHB_12545	ENOG4105CN1	protease
XFHB_12550	ENOG41063SB	peptidase
XFHB_12565	ENOG4105BZ8	glutamate synthase
XFHB_12570	ENOG4105CBC	glutamate synthase
XFHB_12575	ENOG4105II7	pyrroline-5-carboxylate reductase
XFHB_12595	ENOG4105UBK	short-chain dehydrogenase reductase
XFHB_12645	ENOG41082EK	Restriction modification system DNA (Specificity
XFHB_12665	ENOG410829K	Lysine exporter protein (Lyse ygga)
XFHB_12705	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFHB_12720	ENOG4105CVR	type I restriction-modification system
XFHB_12810	ENOG4105YES	addiction module antidote protein
XFHB_12815	ENOG4105VUH	addiction module killer protein
XFHB_12880	ENOG4105CKT	filamentous hemagglutinin
XFHB_12885	ENOG4105CKT	filamentous hemagglutinin
XFHB_12895	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
XFHB_12905	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
XFHB_12910	ENOG4107FTS	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
XFHB_12970	ENOG4105C9U	ATP-dependent DNA helicase RecQ
XFHB_13040	ENOG4107QHF	type ii secretion system protein e
XFHB_13100	ENOG4105C26	Dehydrogenase
XFHB_13115	ENOG4108C33	Resolvase