locus-tag	class	description
OY18_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
OY18_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
OY18_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
OY18_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
OY18_00035	ENOG4108K0D	peptidase, M48
OY18_00075	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
OY18_00095	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
OY18_00110	ENOG4108ZUW	Major pilin subunit
OY18_00145	ENOG4105CGF	Aromatic amino acid aminotransferase
OY18_00170	ENOG4105D6S	protein involved in catabolism of external DNA
OY18_00180	ENOG4108JA2	transcriptioN-repair coupling factor
OY18_00190	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
OY18_00195	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
OY18_00200	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
OY18_00205	ENOG4105C4R	Atp-dependent dna helicase
OY18_00215	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
OY18_00230	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
OY18_00240	ENOG4105MJ2	Competence protein
OY18_00245	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
OY18_00250	ENOG4105D78	K07001 NTE family protein
OY18_00255	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
OY18_00290	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
OY18_00300	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OY18_00330	ENOG4108VEV	chaperone
OY18_00335	ENOG4105X0I	Fimbrial
OY18_00340	ENOG4107TH8	cina domain protein
OY18_00345	ENOG4105CSH	Transporter
OY18_00350	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
OY18_00355	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
OY18_00360	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
OY18_00365	ENOG4105EEI	dihydropteroate synthase
OY18_00375	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
OY18_00380	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
OY18_00385	ENOG4105HBR	Rna-binding protein
OY18_00395	ENOG4105C01	Dihydroxy-acid dehydratase
OY18_00420	ENOG4105D1S	lipid A biosynthesis
OY18_00425	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
OY18_00435	ENOG4105K5M	30s ribosomal protein S16
OY18_00440	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
OY18_00445	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
OY18_00450	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
OY18_00455	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
OY18_00460	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
OY18_00465	ENOG4105KUZ	arsenate reductase
OY18_00470	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
OY18_00475	ENOG4105CAQ	asparagine synthetase
OY18_00485	ENOG4105EA8	2-Nitropropane dioxygenase
OY18_00490	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
OY18_00495	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
OY18_00515	ENOG4105DGW	oligopeptidase A
OY18_00525	ENOG4105E3B	Multicopper oxidase
OY18_00535	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
OY18_00555	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
OY18_00575	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
OY18_00585	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
OY18_00590	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
OY18_00605	ENOG4105C75	arginyL-tRNA synthetase
OY18_00610	ENOG4105W5Q	DNA repair protein (RadC
OY18_00615	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
OY18_00625	ENOG4107QKV	phosphomannomutase
OY18_00635	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
OY18_00670	ENOG4105EYM	Major Facilitator superfamily
OY18_00675	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
OY18_00680	ENOG4105DR5	peptidase
OY18_00685	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
OY18_00715	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
OY18_00740	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
OY18_00745	ENOG4108UT2	hemolysin iii
OY18_00755	ENOG4105EYA	deoxyribonuclease
OY18_00770	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
OY18_00775	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
OY18_00785	ENOG4107QX8	SPFH domain, Band 7 family protein
OY18_00790	ENOG4105DXN	mazG family
OY18_00795	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
OY18_00800	ENOG4107RK2	ADP-ribose diphosphatase NudE
OY18_00810	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
OY18_00815	ENOG4105C1J	atp-dependent rna helicase
OY18_00820	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
OY18_00850	ENOG4108YXA	Membrane
OY18_00855	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
OY18_00860	ENOG4105C0B	DNA polymerase III (alpha subunit)
OY18_00880	ENOG4105CRQ	synthase (Component I)
OY18_00885	ENOG4105DDQ	anthranilate synthase
OY18_00890	ENOG4107QYG	anthranilate phosphoribosyltransferase
OY18_00895	ENOG4105DK0	Indole-3-glycerol phosphate synthase
OY18_00915	ENOG4105DC7	peptidase M24
OY18_00930	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
OY18_00935	ENOG4105VIE	preprotein translocase, subunit YajC
OY18_00940	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
OY18_00945	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
OY18_00955	ENOG4105DJ0	Poly(A) Polymerase
OY18_00960	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OY18_00965	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
OY18_00970	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
OY18_00975	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
OY18_00980	ENOG4107QP8	phosphohexose isomerase
OY18_00995	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
OY18_01000	ENOG4105CHV	Transcription elongation factor NusA
OY18_01005	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
OY18_01010	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
OY18_01015	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
OY18_01020	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
OY18_01025	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
OY18_01035	ENOG4105ECR	NmrA family
OY18_01080	ENOG4105C10	Electron transfer flavoprotein
OY18_01085	ENOG4105BZJ	Electron transfer flavoprotein
OY18_01100	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
OY18_01115	ENOG4107QKV	phosphomannomutase
OY18_01145	ENOG4105CBP	Major Facilitator
OY18_01160	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
OY18_01165	ENOG4105DFU	Cell wall formation (By similarity)
OY18_01170	ENOG410841Q	phosphoesterase PA-phosphatase related protein
OY18_01180	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
OY18_01185	ENOG4105C02	permease
OY18_01205	ENOG4105C0H	protease
OY18_01210	ENOG4105ECP	epimerase
OY18_01220	ENOG4107QM5	aconitate hydratase
OY18_01235	ENOG4107QIJ	Aconitate hydratase 2
OY18_01260	ENOG4105DZR	Type I site-specific deoxyribonuclease
OY18_01315	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OY18_01325	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OY18_01335	ENOG4105GKE	subunit e
OY18_01340	ENOG4107QIZ	NADH dehydrogenase
OY18_01345	ENOG4108IEH	NADH dehydrogenase subunit g
OY18_01355	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
OY18_01360	ENOG4105DF2	NADH dehydrogenase subunit j
OY18_01365	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
OY18_01370	ENOG4105D65	subunit l
OY18_01375	ENOG4105C8S	subunit m
OY18_01380	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
OY18_01385	ENOG4105CHR	reductase
OY18_01390	ENOG4105D4T	Citrate transporter
OY18_01405	ENOG4105DHQ	Histidine kinase
OY18_01420	ENOG4105D7V	transposase
OY18_01450	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
OY18_01455	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
OY18_01460	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
OY18_01470	ENOG4105CDV	Ompa motb domain protein
OY18_01480	ENOG4105CQB	FAD linked oxidase domain protein
OY18_01485	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
OY18_01490	ENOG4105KME	endoribonuclease L-psp
OY18_01495	ENOG4105CB5	ATP-dependent DNA helicase recG
OY18_01500	ENOG4106A3M	Cytochrome p-450
OY18_01515	ENOG4105CDU	Replicative dna helicase
OY18_01520	ENOG4105CDV	Ompa motb domain protein
OY18_01525	ENOG4108RVA	ribokinase
OY18_01530	ENOG4105CPC	Aldo Keto reductase
OY18_01535	ENOG4108JQC	penicillin-binding protein 1A
OY18_01570	ENOG4105DIJ	Phosphoethanolamine transferase
OY18_01575	ENOG4106A3M	Cytochrome p-450
OY18_01580	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
OY18_01605	ENOG4105UGU	tonB-dependent Receptor
OY18_01610	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
OY18_01620	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
OY18_01625	ENOG4105IFJ	Histidine kinase
OY18_01630	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
OY18_01645	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
OY18_01655	ENOG4108UQY	Iron-storage protein
OY18_01685	ENOG4105DU1	integral membrane protein, terc
OY18_01690	ENOG4105DR4	Methyltransferase
OY18_01695	ENOG4105CUB	amino acid
OY18_01710	ENOG4107QSV	RmuC domain protein
OY18_01735	ENOG4107PE3	Mammalian cell entry related domain protein
OY18_01740	ENOG4105CY3	ABC transporter, permease
OY18_01745	ENOG4105DHJ	ABC, transporter
OY18_01750	ENOG4105DSY	exodeoxyribonuclease V, gamma
OY18_01755	ENOG4107QKA	exodeoxyribonuclease V beta
OY18_01770	ENOG4105C31	Tryptophanyl-tRNA synthetase
OY18_01775	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
OY18_01785	ENOG4105KTH	gatB Yqey
OY18_01790	ENOG4105VCC	30S ribosomal protein S21
OY18_01795	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
OY18_01800	ENOG4107ZVW	dihydroneopterin aldolase
OY18_01805	ENOG4105CUY	Mechanosensitive ion channel
OY18_01810	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
OY18_01825	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
OY18_01835	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
OY18_01850	ENOG4105M3Z	response regulator
OY18_01860	ENOG4107QJR	hflk protein
OY18_01865	ENOG4105EPW	hflc protein
OY18_01875	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
OY18_01880	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
OY18_01885	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
OY18_01890	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
OY18_01910	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
OY18_01915	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
OY18_01920	ENOG4105D06	uba thif-type nad fad binding protein
OY18_01930	ENOG41066DG	(EAL) domain protein
OY18_01935	ENOG4105EWT	decarboxylase family
OY18_01940	ENOG4106855	Competence protein
OY18_01985	ENOG4108UUM	single-stranded DNA-binding protein
OY18_02005	ENOG4108ZUW	Major pilin subunit
OY18_02135	ENOG4105KUS	lysozyme
OY18_02245	ENOG4105D7V	transposase
OY18_02255	ENOG4105X0D	Fimbrial protein
OY18_02290	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
OY18_02295	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
OY18_02300	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
OY18_02305	ENOG41082RQ	UPF0102 protein
OY18_02310	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
OY18_02315	ENOG41090JD	Blue (Type 1) copper domain protein
OY18_02325	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
OY18_02340	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
OY18_02355	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
OY18_02365	ENOG4105DH7	May be involved in recombination (By similarity)
OY18_02370	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
OY18_02380	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
OY18_02395	ENOG4105C9K	Endothelin-converting enzyme 1
OY18_02415	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
OY18_02420	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
OY18_02430	ENOG4105C02	permease
OY18_02440	ENOG4108S0S	Nucleotidyl transferase
OY18_02445	ENOG4105EHM	Aminoglycoside phosphotransferase
OY18_02450	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
OY18_02455	ENOG4105CJ2	(LipO)protein
OY18_02480	ENOG4108IU3	tonb-dependent siderophore receptor
OY18_02500	ENOG4105C6T	cysteine synthase
OY18_02515	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
OY18_02520	ENOG4108DMA	Nad-dependent epimerase dehydratase
OY18_02525	ENOG4108IAJ	Nad-dependent epimerase dehydratase
OY18_02550	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
OY18_02560	ENOG4105VF7	tolerance protein
OY18_02565	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
OY18_02570	ENOG4105DWF	phosphomethylpyrimidine kinase
OY18_02575	ENOG4105E2X	shikimate dehydrogenase
OY18_02665	ENOG4108V1T	peptidylprolyl cis-trans isomerase
OY18_02675	ENOG4105CSM	endonuclease III
OY18_02690	ENOG4108YZY	peptidylprolyl cis-trans isomerase
OY18_02695	ENOG4105K4H	Nlp p60 protein
OY18_02700	ENOG4105K4H	Nlp p60 protein
OY18_02720	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
OY18_02725	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
OY18_02730	ENOG4105CTB	Polyprenyl synthetase
OY18_02745	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
OY18_02750	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
OY18_02755	ENOG4105CHR	reductase
OY18_02765	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
OY18_02775	ENOG4105HHA	aminodeoxychorismate lyase
OY18_02780	ENOG4107QRG	dna polymerase iii
OY18_02800	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
OY18_02805	ENOG4105ECY	inositol monophosphatase
OY18_02815	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
OY18_02825	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
OY18_02830	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
OY18_02835	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
OY18_02850	ENOG4105DWV	Homoserine O-trans-acetylase
OY18_02865	ENOG4105KWW	Biogenesis protein
OY18_02870	ENOG4107QX9	Thiol disulfide interChange protein
OY18_02875	ENOG4105DA4	cytochrome c-type biogenesis protein
OY18_02880	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
OY18_02885	ENOG41060IM	Heme exporter protein
OY18_02890	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
OY18_02895	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
OY18_02900	ENOG4105CHM	Aminotransferase
OY18_02915	ENOG4105FE9	pseudouridine synthase
OY18_02925	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
OY18_02945	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
OY18_02950	ENOG4105DRS	transport system, permease
OY18_02970	ENOG4105DWY	Agmatine deiminase
OY18_02985	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
OY18_02990	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
OY18_03000	ENOG4105CFV	Tetratricopeptide repeat protein
OY18_03015	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
OY18_03020	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
OY18_03025	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
OY18_03030	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
OY18_03045	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
OY18_03050	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
OY18_03055	ENOG4105K46	50S ribosomal protein l27
OY18_03060	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OY18_03065	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
OY18_03070	ENOG4105CJR	Integral membrane protein (MviN
OY18_03075	ENOG4105DTN	riboflavin biosynthesis protein ribF
OY18_03080	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
OY18_03085	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
OY18_03170	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
OY18_03175	ENOG4108JJA	ABC, transporter
OY18_03205	ENOG4105DQ4	alcohol dehydrogenase
OY18_03220	ENOG4105BZS	acriflavin resistance protein
OY18_03225	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
OY18_03230	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
OY18_03245	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
OY18_03250	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
OY18_03255	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
OY18_03270	ENOG4105D3Q	Sugar transferase
OY18_03285	ENOG4107UFF	group 1 glycosyl transferase
OY18_03300	ENOG4108NQK	Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a
OY18_03305	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
OY18_03310	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
OY18_03315	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
OY18_03320	ENOG41080ZE	Adenylate cyclase
OY18_03325	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
OY18_03330	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
OY18_03340	ENOG4105VEQ	Cold shock protein
OY18_03350	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
OY18_03365	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
OY18_03370	ENOG41090R7	Ferric uptake
OY18_03375	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
OY18_03385	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OY18_03390	ENOG4105CFG	Acts as a chaperone (By similarity)
OY18_03395	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
OY18_03405	ENOG4105ETX	regulatoR
OY18_03410	ENOG41080IJ	Diacylglycerol kinase
OY18_03415	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
OY18_03420	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
OY18_03435	ENOG4108IUW	ABC transporter
OY18_03440	ENOG4108SDH	ABC, transporter
OY18_03450	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
OY18_03460	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
OY18_03500	ENOG4105KUS	lysozyme
OY18_03515	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
OY18_03520	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
OY18_03535	ENOG4105D52	delta-aminolevulinic acid dehydratase
OY18_03540	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
OY18_03555	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
OY18_03560	ENOG4105D1F	ATP-binding protein
OY18_03565	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
OY18_03600	ENOG4105WXW	Antirepressor
OY18_03665	ENOG41078CG	DNA-binding transcriptional regulator
OY18_03710	ENOG4105KUS	lysozyme
OY18_03755	ENOG4108C66	Inherit from COG: DNA primase
OY18_03790	ENOG4106GMR	
OY18_03810	ENOG4106GZK	Protein of unknown function (DUF2669)
OY18_03825	ENOG4105VG9	Plasmid stabilization system
OY18_03860	ENOG4105YES	addiction module antidote protein
OY18_03865	ENOG4105VUH	addiction module killer protein
OY18_03935	ENOG4105WXW	Antirepressor
OY18_04120	ENOG4105WJ3	XRE family Transcriptional regulator
OY18_04125	ENOG4105RT5	Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation
OY18_04200	ENOG4108UUM	single-stranded DNA-binding protein
OY18_04220	ENOG4108HJ1	Uncharacterized conserved protein (DUF2303)
OY18_04225	ENOG4105H40	
OY18_04310	ENOG4105WXW	Antirepressor
OY18_04325	ENOG4105CDU	Replicative dna helicase
OY18_04330	ENOG4106FAK	Endodeoxyribonuclease RusA
OY18_04340	ENOG4105KUS	lysozyme
OY18_04410	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
OY18_04485	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
OY18_04505	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
OY18_04530	ENOG4105C3K	feS assembly ATPase SufC
OY18_04540	ENOG4105C9B	Cysteine desulfurase
OY18_04550	ENOG4107QPH	glycogen) synthase
OY18_04555	ENOG4107BJW	polysaccharide deacetylase
OY18_04560	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
OY18_04565	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
OY18_04570	ENOG4105CE4	GlcNAc 6-P deacetylase
OY18_04575	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
OY18_04580	ENOG4105ETE	Transcriptional regulator (LacI family
OY18_04595	ENOG4105CHC	glucokinase (EC 2.7.1.2)
OY18_04610	ENOG410642E	Short chain dehydrogenase
OY18_04620	ENOG4105BZU	Histidine kinase
OY18_04625	ENOG4105WMR	Protein CrcB homolog
OY18_04630	ENOG4105D1H	recombination factor protein RarA
OY18_04635	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
OY18_04645	ENOG4105CNU	cell division protein FtsK
OY18_04650	ENOG4105C3M	thioredoxin reductase
OY18_04660	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
OY18_04665	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
OY18_04670	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
OY18_04675	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
OY18_04690	ENOG41075W9	High frequency lysogenization protein HflD homolog
OY18_04700	ENOG4108Z33	Thiol disulfide Interchange Protein
OY18_04705	ENOG4108Z33	Thiol disulfide Interchange Protein
OY18_04720	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
OY18_04730	ENOG4105C8Y	Acetylornithine aminotransferase
OY18_04735	ENOG4105EYW	Ion transport protein
OY18_04740	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
OY18_04745	ENOG4105T95	Thiol disulfide interChange protein
OY18_04790	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
OY18_04800	ENOG4105C2X	Arabinose 5-phosphate isomerase
OY18_04805	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
OY18_04820	ENOG4108IUZ	ABC transporter
OY18_04825	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
OY18_04830	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
OY18_04840	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
OY18_04850	ENOG41080Z8	PHOSPHOCARRIER protein
OY18_04860	ENOG4105CJW	magnesium transporter
OY18_04880	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
OY18_04885	ENOG4108UUM	single-stranded DNA-binding protein
OY18_04890	ENOG4105EAH	synthase
OY18_04895	ENOG4105E2S	oxidase) subunit II
OY18_04900	ENOG4105BZ9	Cytochrome C oxidase, subunit I
OY18_04905	ENOG4105CCU	oxidase (Subunit III)
OY18_04910	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
OY18_04915	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
OY18_04930	ENOG4105CQ7	ATP-dependent helicase
OY18_04940	ENOG4105C9U	ATP-dependent DNA helicase RecQ
OY18_04950	ENOG4108M8W	Monooxygenase
OY18_04955	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
OY18_04960	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
OY18_04965	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
OY18_04970	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
OY18_04975	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
OY18_04985	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
OY18_04990	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
OY18_04995	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
OY18_05005	ENOG4105DJ4	phosphatidylserine decarboxylase
OY18_05015	ENOG4107SC1	transglycosylase
OY18_05020	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
OY18_05025	ENOG4107U32	Beta-lactamase domain protein
OY18_05030	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
OY18_05040	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
OY18_05045	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
OY18_05055	ENOG4105NTK	Transcriptional repressor Mpra
OY18_05060	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
OY18_05065	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
OY18_05085	ENOG4108I5D	sulfate abc transporter
OY18_05090	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
OY18_05110	ENOG4105CX6	glutaminyL-tRNA synthetase
OY18_05115	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
OY18_05125	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
OY18_05135	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
OY18_05185	ENOG4107QMS	site-determining protein
OY18_05205	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
OY18_05210	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
OY18_05215	ENOG4105CNI	cell division protein FtsW
OY18_05220	ENOG4105CJN	penicillin-binding protein
OY18_05235	ENOG4105DFF	Rod shape-determining protein mreb
OY18_05280	ENOG4105DHJ	ABC, transporter
OY18_05285	ENOG4108SNX	Mammalian cell entry related domain protein
OY18_05300	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
OY18_05310	ENOG4108DG9	Smr protein MutS2
OY18_05315	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
OY18_05320	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
OY18_05325	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
OY18_05330	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
OY18_05335	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
OY18_05340	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
OY18_05350	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
OY18_05370	ENOG4106BRA	Membrane
OY18_05395	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
OY18_05400	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
OY18_05405	ENOG41065HY	1,4-beta-cellobiosidase
OY18_05425	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
OY18_05440	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
OY18_05465	ENOG4105DN3	alpha-2-macroglobulin domain protein
OY18_05485	ENOG4105C7F	AcnD-accessory protein PrpF
OY18_05490	ENOG4108I0Z	Aconitate hydratase
OY18_05575	ENOG4108KU3	Integrase
OY18_05585	ENOG4105CR4	methylisocitrate lyase
OY18_05590	ENOG4105MA0	exported protein
OY18_05595	ENOG4105CFU	surface antigen
OY18_05605	ENOG4105CQ7	ATP-dependent helicase
OY18_05620	ENOG4105DA5	(ABC) transporter
OY18_05625	ENOG4105E3A	(ABC) transporter
OY18_05630	ENOG4108JJA	ABC, transporter
OY18_05640	ENOG4108MBX	Secretion Protein
OY18_05650	ENOG4105CI3	gtp-binding protein typa
OY18_05655	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
OY18_05660	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
OY18_05665	ENOG4108K3A	Glutathione S-transferase
OY18_05670	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
OY18_05700	ENOG4105I08	Pseudouridine synthase
OY18_05715	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
OY18_05720	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
OY18_05730	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
OY18_05745	ENOG4105K70	DNA-binding protein
OY18_05755	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
OY18_05760	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
OY18_05765	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
OY18_05780	ENOG4107QQG	Dehydrogenase
OY18_05790	ENOG4105MGK	May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity)
OY18_05800	ENOG4105C0P	Mg chelatase subunit ChlI
OY18_05805	ENOG4105W0Z	cytoplasmic protein
OY18_05810	ENOG4108ZT0	50S ribosomal protein l17
OY18_05820	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
OY18_05825	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
OY18_05830	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OY18_05840	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
OY18_05845	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
OY18_05850	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
OY18_05855	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
OY18_05860	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
OY18_05865	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OY18_05870	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
OY18_05875	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
OY18_05880	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
OY18_05885	ENOG41083MP	50s ribosomal protein l29
OY18_05900	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
OY18_05910	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OY18_05915	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
OY18_05920	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
OY18_05930	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
OY18_05935	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
OY18_05940	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
OY18_05945	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
OY18_05950	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
OY18_05955	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
OY18_05960	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
OY18_05965	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
OY18_05975	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
OY18_05990	ENOG4105DQ4	alcohol dehydrogenase
OY18_06000	ENOG4107ZS6	Flavodoxin
OY18_06005	ENOG4105CC0	LysR family Transcriptional regulator
OY18_06010	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
OY18_06015	ENOG4105N42	UPF0307 protein
OY18_06020	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
OY18_06030	ENOG4105C03	ribonuclease
OY18_06035	ENOG4108Z03	MAF-like protein
OY18_06060	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
OY18_06075	ENOG4105E39	Enoyl-CoA hydratase
OY18_06080	ENOG4105BZU	Histidine kinase
OY18_06085	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
OY18_06090	ENOG4105CRK	lysyL-tRNA synthetase
OY18_06095	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
OY18_06100	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
OY18_06110	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
OY18_06120	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
OY18_06125	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
OY18_06135	ENOG4105C2M	dna polymerase I
OY18_06150	ENOG4107RH7	Nicotinate phosphoribosyltransferase
OY18_06155	ENOG4105CS1	NAD(P)H quinone oxidoreductase
OY18_06165	ENOG4107RZC	phospholipase d
OY18_06205	ENOG4108EC8	DNA internalization-related competence protein ComEC
OY18_06210	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
OY18_06215	ENOG4105D60	lipoprotein releasing system transmembrane protein
OY18_06255	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
OY18_06260	ENOG4108IJ9	(ABC) transporter
OY18_06265	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
OY18_06270	ENOG4105CHC	glucokinase (EC 2.7.1.2)
OY18_06275	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
OY18_06280	ENOG4105C01	Dihydroxy-acid dehydratase
OY18_06285	ENOG4108UHU	Aldolase
OY18_06310	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
OY18_06330	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
OY18_06335	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
OY18_06340	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
OY18_06345	ENOG4105KNE	Phosphatidate cytidylyltransferase
OY18_06350	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
OY18_06355	ENOG4105DZP	Membrane-associated zinc metalloprotease
OY18_06360	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OY18_06365	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
OY18_06370	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
OY18_06375	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
OY18_06380	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
OY18_06385	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
OY18_06395	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
OY18_06430	ENOG4105C29	acyl-CoA thioesterase
OY18_06440	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
OY18_06445	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
OY18_06450	ENOG4105KST	dependent repressor
OY18_06455	ENOG4108Z6B	deaminase
OY18_06460	ENOG4105DDI	hemolysin-type calcium-binding region
OY18_06500	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
OY18_06505	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
OY18_06510	ENOG4105CH7	arginosuccinase
OY18_06520	ENOG4105CAS	nag kinase
OY18_06530	ENOG4105CDH	Citrulline--aspartate ligase
OY18_06535	ENOG4105DBV	ornithine carbamoyltransferase
OY18_06545	ENOG4105C8N	cysteinyl-tRNA synthetase
OY18_06550	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
OY18_06555	ENOG4105E8G	Major facilitator Superfamily
OY18_06565	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
OY18_06570	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
OY18_06575	ENOG4105CD3	dihydroorotase
OY18_06585	ENOG4105BZU	Histidine kinase
OY18_06595	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
OY18_06605	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
OY18_06610	ENOG4106H78	methyltransferase
OY18_06615	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
OY18_06620	ENOG4105C6K	Malic enzyme
OY18_06625	ENOG4105CK2	sodium dicarboxylate symporter
OY18_06660	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
OY18_06675	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
OY18_06705	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
OY18_06710	ENOG4107YIM	Involved in the transcription termination process (By similarity)
OY18_06715	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
OY18_06720	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
OY18_06730	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
OY18_06735	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
OY18_06745	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
OY18_06750	ENOG4105C5H	ABC transporter
OY18_06755	ENOG4105DWT	malate dehydrogenase (quinone)
OY18_06760	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
OY18_06770	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
OY18_06775	ENOG4105C34	Pseudouridine synthase
OY18_06780	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
OY18_06800	ENOG4105CE1	Ferrous iron transport protein b
OY18_06810	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
OY18_06820	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
OY18_06835	ENOG4105C79	DNA protecting protein DprA
OY18_06840	ENOG4108RPN	Protein smg homolog
OY18_06845	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
OY18_06850	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
OY18_06885	ENOG4105KB2	stringent starvation protein b
OY18_06890	ENOG4107MKT	Stringent starvation protein a
OY18_06895	ENOG4105EIX	cytochrome c1
OY18_06900	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
OY18_06905	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
OY18_06915	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
OY18_06920	ENOG4105C9A	Phoh family
OY18_06925	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
OY18_06935	ENOG4108JU5	Magnesium and cobalt efflux protein
OY18_07070	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
OY18_07080	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
OY18_07085	ENOG4105CQB	FAD linked oxidase domain protein
OY18_07090	ENOG4108JQ1	Dehydrogenase
OY18_07095	ENOG4105CUB	amino acid
OY18_07100	ENOG4105CUB	amino acid
OY18_07105	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
OY18_07110	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
OY18_07115	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
OY18_07120	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
OY18_07130	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
OY18_07140	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
OY18_07150	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
OY18_07155	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
OY18_07165	ENOG4105CUT	histidyl-tRNA synthetase
OY18_07175	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
OY18_07180	ENOG4105CFH	Aspartokinase
OY18_07185	ENOG4105CXT	aspartate transcarbamylase
OY18_07195	ENOG4108UJU	UPF0301 protein
OY18_07200	ENOG4105DZ1	carboxypeptidase
OY18_07210	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
OY18_07225	ENOG4108JQB	penicillin-binding protein 1C
OY18_07240	ENOG4105EMN	RNA polymerase sigma factor
OY18_07250	ENOG4105C0H	protease
OY18_07255	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
OY18_07260	ENOG4105C3F	Signal peptidase i
OY18_07270	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
OY18_07275	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
OY18_07280	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
OY18_07285	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
OY18_07290	ENOG4107QN1	sodium solute
OY18_07315	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
OY18_07320	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
OY18_07325	ENOG4105EPD	Oligopeptide transporter, Opt family
OY18_07335	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
OY18_07340	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
OY18_07345	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
OY18_07355	ENOG4105DSB	aldose 1-epimerase
OY18_07360	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
OY18_07365	ENOG4105WPN	DNA integration recombination invertion protein
OY18_07375	ENOG410680H	amp-dependent synthetase and ligase
OY18_07395	ENOG4105FA0	parb-like partition protein
OY18_07400	ENOG4107QJE	Chromosome Partitioning Protein
OY18_07410	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
OY18_07465	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
OY18_07470	ENOG4105CD8	aminopeptidase N
OY18_07495	ENOG41063JG	Transcriptional regulator
OY18_07510	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
OY18_07515	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
OY18_07525	ENOG4105C11	sulfate adenylyltransferase), subunit 2
OY18_07530	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
OY18_07535	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
OY18_07540	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
OY18_07545	ENOG4105DSJ	YicC domain protein
OY18_07550	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
OY18_07555	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
OY18_07560	ENOG4105CSA	Coproporphyrinogen iii oxidase
OY18_07575	ENOG4108HGY	Proline imino-peptidase
OY18_07580	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
OY18_07595	ENOG4105EUR	Domain-Containing protein
OY18_07600	ENOG4107QHF	type ii secretion system protein e
OY18_07605	ENOG4105D7Q	type ii secretion system
OY18_07615	ENOG4105WMT	general secretion pathway protein h
OY18_07625	ENOG41069G9	General secretion pathway protein J
OY18_07635	ENOG41090VX	general secretion pathway protein L
OY18_07640	ENOG410678M	general secretion pathway protein M
OY18_07650	ENOG4105GVR	general secretion pathway protein D
OY18_07660	ENOG4105D3R	alkyl hydroperoxide reductase
OY18_07670	ENOG4105C5Q	Transcriptional regulator
OY18_07675	ENOG41072GX	Peptidase M22 Glycoprotease
OY18_07680	ENOG4105NRA	50s ribosomal protein l31 type b
OY18_07685	ENOG4105BZN	citrate synthase
OY18_07690	ENOG4108UJD	30S ribosomal protein S9
OY18_07695	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
OY18_07700	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
OY18_07705	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
OY18_07720	ENOG4105CUZ	uba thif-type nad fad binding protein
OY18_07740	ENOG4105C7S	Dehydrogenase
OY18_07745	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
OY18_07750	ENOG4105EZE	Cupin 4 family protein
OY18_07755	ENOG4107QTF	adenylosuccinate lyase
OY18_07765	ENOG4105C9Q	fumarate hydratase class II
OY18_07775	ENOG4108UUM	single-stranded DNA-binding protein
OY18_07805	ENOG4106FAK	Endodeoxyribonuclease RusA
OY18_07825	ENOG4105KUS	lysozyme
OY18_07870	ENOG4108C66	Inherit from COG: DNA primase
OY18_07905	ENOG4106GMR	
OY18_07925	ENOG4106GZK	Protein of unknown function (DUF2669)
OY18_07965	ENOG4105YES	addiction module antidote protein
OY18_07970	ENOG4105VUH	addiction module killer protein
OY18_07990	ENOG4105CZV	ABC transporter
OY18_07995	ENOG4108V06	Glutathione peroxidase
OY18_08005	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
OY18_08025	ENOG4105D7K	pfkb domain protein
OY18_08035	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
OY18_08050	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
OY18_08065	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
OY18_08075	ENOG4108HRK	Histidine kinase
OY18_08080	ENOG4108NEV	two component transcriptional regulator, LytTR family
OY18_08085	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
OY18_08100	ENOG4105CZX	twitching motility protein
OY18_08105	ENOG4105CZX	twitching motility protein
OY18_08115	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
OY18_08125	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
OY18_08145	ENOG4105M4H	endoribonuclease L-psp
OY18_08160	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
OY18_08165	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
OY18_08170	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
OY18_08175	ENOG4105DFA	alanine racemase domain protein
OY18_08185	ENOG4105DFP	Integrase
OY18_08205	ENOG4105CPC	Aldo Keto reductase
OY18_08210	ENOG4105CPC	Aldo Keto reductase
OY18_08215	ENOG4105VW8	4-oxalocrotonate tautomerase
OY18_08235	ENOG4107S5I	aldo keto reductase
OY18_08240	ENOG4105HEI	LysR family (Transcriptional regulator
OY18_08245	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
OY18_08255	ENOG4105DQ4	alcohol dehydrogenase
OY18_08260	ENOG4105D8V	Glucose sorbosone dehydrogenase
OY18_08285	ENOG4105D8V	Glucose sorbosone dehydrogenase
OY18_08290	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
OY18_08295	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
OY18_08305	ENOG4105EMU	Dehydrogenase
OY18_08310	ENOG4105ENX	hydrolase
OY18_08315	ENOG4105DQ4	alcohol dehydrogenase
OY18_08330	ENOG4107RTG	Major Facilitator superfamily
OY18_08335	ENOG4105ENX	hydrolase
OY18_08345	ENOG4105EQ2	LysR family Transcriptional regulator
OY18_08435	ENOG4105EQ2	LysR family Transcriptional regulator
OY18_08480	ENOG4105NI8	Cytosine-specific methyltransferase
OY18_08490	ENOG4107YH6	single-stranded DNA-binding protein
OY18_08530	ENOG4107QJE	Chromosome Partitioning Protein
OY18_08575	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
OY18_08580	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
OY18_08605	ENOG4107YZP	Rhodanese domain protein
OY18_08610	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
OY18_08615	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
OY18_08645	ENOG4107QMP	dna polymerase iii subunits gamma and tau
OY18_08650	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
OY18_08655	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
OY18_08660	ENOG4105K59	histidine triad (HIT) protein
OY18_08670	ENOG4105F8C	transglutaminase domain-containing protein
OY18_08680	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
OY18_08690	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
OY18_08695	ENOG4105VGS	50s ribosomal protein l32
OY18_08705	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
OY18_08710	ENOG4105C7B	Threonine dehydratase
OY18_08725	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
OY18_08730	ENOG4105CN1	protease
OY18_08735	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
OY18_08740	ENOG4108ZHJ	Organic hydroperoxide resistance protein
OY18_08745	ENOG4105D6Z	AFG1 family ATPase
OY18_08770	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
OY18_08780	ENOG4105RKW	reductase (By
OY18_08805	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
OY18_08810	ENOG4105C5F	glutamine synthetase
OY18_08820	ENOG4105BZU	Histidine kinase
OY18_08825	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
OY18_08830	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
OY18_08835	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
OY18_08865	ENOG4107GFK	fumarate
OY18_08870	ENOG4105C9M	aspartyl-trna synthetase
OY18_08875	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
OY18_08895	ENOG4108UUM	single-stranded DNA-binding protein
OY18_08925	ENOG4108ZUW	Major pilin subunit
OY18_09120	ENOG4108UUM	single-stranded DNA-binding protein
OY18_09140	ENOG4108ZUW	Major pilin subunit
OY18_09270	ENOG4105KUS	lysozyme
OY18_09380	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
OY18_09400	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
OY18_09405	ENOG4108Z0R	Transferase
OY18_09410	ENOG4105BZS	acriflavin resistance protein
OY18_09430	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
OY18_09460	ENOG4105BZS	acriflavin resistance protein
OY18_09465	ENOG4105CHR	reductase
OY18_09495	ENOG4105C26	Dehydrogenase
OY18_09505	ENOG4105X54	addiction module antidote protein
OY18_09725	ENOG4108C33	Resolvase
OY18_09750	ENOG4105CJB	Exodeoxyribonuclease I
OY18_09765	ENOG4105EEQ	Na H antiporter
OY18_09775	ENOG4105E66	phosphoriboisomerase A
OY18_09785	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
OY18_09790	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
OY18_09805	ENOG4107RAQ	aminopeptidase
OY18_09845	ENOG4105CM2	brancheD-chain amino acid aminotransferase
OY18_09850	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
OY18_09870	ENOG4106WTF	Glycosyl transferase, family 2
OY18_09880	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
OY18_09885	ENOG4107ZT5	Thiol disulfide interchange protein
OY18_09895	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
OY18_09905	ENOG4105C2N	RNA methyltransferase TrmH family group 3
OY18_09910	ENOG4108Z0R	Transferase
OY18_09915	ENOG4105EUJ	GTP cyclohydrolase i
OY18_09930	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
OY18_09935	ENOG4105EM2	membrane
OY18_09945	ENOG4105C12	Phosphoribosylglycinamide synthetase
OY18_09950	ENOG4105DC1	bifunctional purine biosynthesis protein purh
OY18_09960	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
OY18_09970	ENOG4105E2T	synthase III
OY18_09985	ENOG4108J2P	Alpha beta hydrolase fold
OY18_09990	ENOG4105PI0	Ferredoxin
OY18_10000	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
OY18_10005	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
OY18_10020	ENOG4105D7Z	glutathione synthase
OY18_10025	ENOG4108UNF	response regulator
OY18_10030	ENOG4108ZGA	chew protein
OY18_10035	ENOG4105C8Q	Methyl-accepting chemotaxis
OY18_10040	ENOG4105CBS	Chea signal transduction histidine kinase
OY18_10055	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
OY18_10070	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
OY18_10080	ENOG4105DGW	oligopeptidase A
OY18_10100	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
OY18_10105	ENOG4105CK2	sodium dicarboxylate symporter
OY18_10110	ENOG4105CV1	Transketolase (EC 2.2.1.1)
OY18_10115	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
OY18_10160	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
OY18_10165	ENOG4108IYU	L-aspartate oxidase
OY18_10170	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
OY18_10180	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
OY18_10220	ENOG4105F8V	Hydrolase, tatD family
OY18_10235	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
OY18_10240	ENOG4105CEN	a g-specific adenine glycosylase
OY18_10245	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
OY18_10250	ENOG4105CDY	transcriptional regulatory protein
OY18_10255	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
OY18_10260	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
OY18_10265	ENOG4105DFH	Transport of potassium into the cell (By similarity)
OY18_10270	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
OY18_10275	ENOG4107YD3	Thioesterase
OY18_10280	ENOG4105E02	MotA TolQ exbB proton channel
OY18_10285	ENOG4105M8F	Biopolymer transport protein exbD tolR
OY18_10295	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
OY18_10300	ENOG4105KCK	Peptidoglycan-associated lipoprotein
OY18_10310	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
OY18_10315	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
OY18_10320	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
OY18_10325	ENOG4105DUX	Transporter
OY18_10330	ENOG4108V06	Glutathione peroxidase
OY18_10335	ENOG4105DP0	ferredoxin-NADP reductase
OY18_10350	ENOG4105CVJ	phosphoglycerate mutase
OY18_10495	ENOG4105KUS	lysozyme
OY18_10540	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
OY18_10575	ENOG4105C5H	ABC transporter
OY18_10580	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
OY18_10585	ENOG4107ZXU	DSBA oxidoreductase
OY18_10590	ENOG4107RNH	Outer membrane receptor FepA
OY18_10600	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
OY18_10605	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
OY18_10610	ENOG4105C8U	phosphate abc transporter
OY18_10615	ENOG4105E2Z	phosphate ABC transporter (Permease
OY18_10620	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
OY18_10625	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
OY18_10630	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
OY18_10635	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
OY18_10640	ENOG4105NWN	ApaG protein
OY18_10645	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
OY18_10655	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
OY18_10660	ENOG4105DKP	glycosyl transferase, family 9
OY18_10675	ENOG4108ZF3	Phosphatase
OY18_10680	ENOG4107RZZ	dna polymerase iii epsilon subunit
OY18_10685	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
OY18_10695	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
OY18_10700	ENOG4105BZM	domain protein
OY18_10715	ENOG4105F0N	pyrophosphate phospho-hydrolase
OY18_10720	ENOG4105K63	Thioredoxin
OY18_10730	ENOG4105C8T	Leucyl-tRNA synthetase
OY18_10745	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
OY18_10770	ENOG4105CVE	Lytic murein transglycosylase
OY18_10775	ENOG4105K6T	rare lipoprotein A
OY18_10885	ENOG4105BZ4	penicillin-binding protein
OY18_10895	ENOG4105DVT	helicase
OY18_10905	ENOG41077A9	carbonic anhydrase
OY18_10920	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
OY18_10925	ENOG4108UMI	ABC transporter, permease
OY18_10930	ENOG4105D01	(LipO)protein
OY18_10940	ENOG4107QSN	dihydrolipoamide acetyltransferase
OY18_10960	ENOG4105C28	cystathionine
OY18_10965	ENOG4106TYC	homoserine o-acetyltransferase (EC 2.3.1.31)
OY18_10970	ENOG4105DR5	peptidase
OY18_10975	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
OY18_10980	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
OY18_10985	ENOG4108UM1	dedA family
OY18_10990	ENOG4108K5P	(LipO)protein
OY18_11000	ENOG4105BZU	Histidine kinase
OY18_11005	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
OY18_11010	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
OY18_11015	ENOG4105E0X	reductase
OY18_11020	ENOG4105VRS	hydrolase family 18
OY18_11050	ENOG4105CWX	Alpha-1,2-mannosidase
OY18_11060	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
OY18_11065	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
OY18_11070	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
OY18_11075	ENOG4105D0A	hydroxylase
OY18_11080	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
OY18_11085	ENOG4107R11	Transcriptional regulator
OY18_11115	ENOG4107R1Y	fructose-bisphosphate aldolase
OY18_11120	ENOG4105CA9	Pyruvate kinase
OY18_11125	ENOG4105BZA	Phosphoglycerate kinase
OY18_11130	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
OY18_11135	ENOG4105MYN	Zinc uptake regulation protein
OY18_11145	ENOG4106R7G	Glycoside hydrolase family 5
OY18_11165	ENOG4108YQE	rare lipoprotein a
OY18_11170	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
OY18_11175	ENOG4105DR5	peptidase
OY18_11185	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
OY18_11190	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
OY18_11195	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
OY18_11200	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
OY18_11205	ENOG4105CPF	Cell wall formation (By similarity)
OY18_11210	ENOG4105DFU	Cell wall formation (By similarity)
OY18_11215	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
OY18_11225	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
OY18_11230	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
OY18_11235	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
OY18_11240	ENOG4105CJN	penicillin-binding protein
OY18_11245	ENOG4106932	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
OY18_11250	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
OY18_11255	ENOG4108V6E	Cell division protein mraZ
OY18_11270	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
OY18_11275	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
OY18_11280	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
OY18_11305	ENOG4105EXC	Acyl-transferase
OY18_11335	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
OY18_11360	ENOG4107QPB	Beta-lactamase domain protein
OY18_11365	ENOG41080HT	Transcriptional regulator, arsr family
OY18_11370	ENOG4105MD1	YeeE YedE family protein
OY18_11375	ENOG4105KFG	YeeE YedE family protein
OY18_11380	ENOG4108VCT	Sulfite exporter TauE/SafE
OY18_11385	ENOG4105DHP	deoxycytidine triphosphate deaminase
OY18_11395	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
OY18_11400	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
OY18_11405	ENOG4105K8N	protein family UPF0079, ATPase
OY18_11410	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
OY18_11420	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
OY18_11460	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
OY18_11465	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
OY18_11470	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
OY18_11475	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
OY18_11485	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
OY18_11490	ENOG4105C22	threonyL-tRNA synthetase
OY18_11565	ENOG41082AG	Plasmid maintenance system antidote protein
OY18_11635	ENOG4105KUS	lysozyme
OY18_11760	ENOG4105WXW	Antirepressor
OY18_11785	ENOG4108J6E	Pfam:Phage_integr_N
OY18_11800	ENOG4105ETX	regulatoR
OY18_11810	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
OY18_11815	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
OY18_11845	ENOG4107QHF	type ii secretion system protein e
OY18_11850	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
OY18_11855	ENOG4107TUY	Histidine kinase
OY18_11865	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
OY18_11875	ENOG4105D5K	Hemolysin activator protein
OY18_11885	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
OY18_11890	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
OY18_11900	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
OY18_11910	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
OY18_11915	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
OY18_11925	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
OY18_11930	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
OY18_11940	ENOG4108Z4V	iron-sulfur cluster assembly
OY18_11945	ENOG4105C5S	asparaginyl-tRNA synthetase
OY18_11970	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
OY18_11975	ENOG4105D4A	Cell wall formation (By similarity)
OY18_11980	ENOG4108SXK	Transporter Drug Metabolite Exporter family
OY18_11985	ENOG410841Q	phosphoesterase PA-phosphatase related protein
OY18_11990	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
OY18_12005	ENOG4108UYB	regulatoR
OY18_12010	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
OY18_12025	ENOG4105BZ1	(ABC) transporter
OY18_12030	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
OY18_12035	ENOG4105DFG	type I secretion outer membrane protein
OY18_12040	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
OY18_12045	ENOG4105C9X	ppx gppa phosphatase
OY18_12050	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
OY18_12055	ENOG4105BZU	Histidine kinase
OY18_12060	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
OY18_12065	ENOG4105ERG	peptidase m48, ste24p
OY18_12070	ENOG4105VW4	glutaredoxin 3
OY18_12075	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
OY18_12085	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
OY18_12095	ENOG4108Z4U	Ferredoxin
OY18_12105	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
OY18_12110	ENOG41090A4	Pterin carbinolamine dehydratase
OY18_12120	ENOG4105EI2	Pseudouridine synthase
OY18_12125	ENOG4105C03	ribonuclease
OY18_12135	ENOG4105C72	UPF0176 protein
OY18_12145	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
OY18_12160	ENOG4105C5H	ABC transporter
OY18_12165	ENOG4105CNG	UPF0061 protein
OY18_12180	ENOG4105D0M	Protease HtpX homolog
OY18_12185	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
OY18_12190	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
OY18_12195	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
OY18_12200	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
OY18_12205	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
OY18_12210	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
OY18_12215	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
OY18_12220	ENOG4108VZM	50s ribosomal protein L10
OY18_12225	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
OY18_12230	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
OY18_12235	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
OY18_12240	ENOG4105PM1	preprotein translocase subunit SecE
OY18_12250	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
OY18_12270	ENOG4105C3G	gtp-binding protein
OY18_12275	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
OY18_12285	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
OY18_12295	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
OY18_12300	ENOG4108D76	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
OY18_12305	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
OY18_12310	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
OY18_12315	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
OY18_12320	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
OY18_12355	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
OY18_12360	ENOG4105M2J	Glutaredoxin
OY18_12365	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
OY18_12370	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
OY18_12375	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
OY18_12385	ENOG4107STQ	Multicopper oxidase
OY18_12395	ENOG4105C4R	Atp-dependent dna helicase
OY18_12400	ENOG4105DJ9	glucan biosynthesis protein
OY18_12405	ENOG4105D07	Signal peptide peptidase, SppA
OY18_12410	ENOG4107QI1	Mate efflux family protein
OY18_12430	ENOG4105C25	Primosomal protein n'
OY18_12440	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
OY18_12445	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
OY18_12450	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
OY18_12455	ENOG4105CAK	Cell division ATP-binding protein ftsE
OY18_12460	ENOG4105C1J	atp-dependent rna helicase
OY18_12465	ENOG4105K63	Thioredoxin
OY18_12470	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
OY18_12475	ENOG4105E9K	Isocitrate dehydrogenase
OY18_12485	ENOG4105CN1	protease
OY18_12490	ENOG41063SB	peptidase
OY18_12505	ENOG4105BZ8	glutamate synthase
OY18_12510	ENOG4105CBC	glutamate synthase
OY18_12515	ENOG4105II7	pyrroline-5-carboxylate reductase
OY18_12535	ENOG4105UBK	short-chain dehydrogenase reductase
OY18_12560	ENOG4105DZR	Type I site-specific deoxyribonuclease
OY18_12585	ENOG41082EK	Restriction modification system DNA (Specificity
OY18_12600	ENOG410829K	Lysine exporter protein (Lyse ygga)
OY18_12640	ENOG4105DZR	Type I site-specific deoxyribonuclease
OY18_12655	ENOG4105CVR	type I restriction-modification system
OY18_12770	ENOG4105YES	addiction module antidote protein
OY18_12775	ENOG4105VUH	addiction module killer protein
OY18_12870	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
OY18_12880	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
OY18_12885	ENOG4107FTS	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
OY18_13020	ENOG4105D7V	transposase
OY18_13025	ENOG4108RS6	transposase
OY18_13120	ENOG4108V42	Type IV secretion system protein VirB8
OY18_13130	ENOG4105CMA	conjugation trbi family protein
OY18_13165	ENOG4108C33	Resolvase
OY18_13295	ENOG4105VUH	addiction module killer protein