locus-tag	class	description
P303_00130	COG3736	Type IV secretory pathway, component VirB8
P303_00215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
P303_00225	COG0642	Histidine kinase
P303_00230	COG0745	RESPONSE REGULATOR receiver
P303_00255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
P303_00335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
P303_00335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
P303_00340	COG0802	atpase or kinase
P303_00345	COG0860	N-Acetylmuramoyl-L-alanine amidase
P303_00405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
P303_00455	COG0471	metal ion transport
P303_00455	COG3273	potassium ion transport
P303_00475	COG3116	cell division
P303_00490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
P303_00530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
P303_00545	COG0739	heme binding
P303_00560	COG4305	rare lipoprotein A
P303_00575	COG0612	Peptidase, M16
P303_00585	COG5297	Belongs to the glycosyl hydrolase family 6
P303_00585	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
P303_00595	COG0735	belongs to the Fur family
P303_00615	COG0469	pyruvate kinase activity
P303_00660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P303_00665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
P303_00695	COG3537	Alpha-1,2-mannosidase
P303_00710	COG1472	Belongs to the glycosyl hydrolase 3 family
P303_00720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
P303_00725	COG3858	chitin binding
P303_00725	COG1388	LysM domain
P303_00765	COG1238	metal cluster binding
P303_00785	COG0739	heme binding
P303_00790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
P303_00795	COG0626	cystathionine gamma-synthase activity
P303_00805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
P303_00810	COG0508	dehydrogenase complex catalyzes the overall conversion of
P303_00825	COG2011	ABC-type metal ion transport system permease component
P303_00850	COG0288	reversible hydration of carbon dioxide
P303_00865	COG2166	iron-sulfur cluster assembly
P303_00895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
P303_00975	COG0590	tRNA wobble adenosine to inosine editing
P303_00980	COG1321	iron dependent repressor
P303_00985	COG1914	H( )-stimulated, divalent metal cation uptake system
P303_01005	COG1946	Acyl-CoA thioesterase
P303_01110	COG0575	Belongs to the CDS family
P303_01140	COG0528	UMP kinase activity
P303_01170	COG0800	Aldolase
P303_01200	COG0354	folic acid binding
P303_01210	COG2009	succinate dehydrogenase
P303_01215	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
P303_01225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
P303_01255	COG0811	peptide transport
P303_01300	COG3077	Addiction module antitoxin, RelB DinJ family
P303_01375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P303_01395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P303_01480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
P303_01485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
P303_01505	COG1024	Enoyl-CoA hydratase
P303_01510	COG0527	aspartate kinase activity
P303_01530	COG0494	nUDIX hydrolase
P303_01535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
P303_01550	COG1530	ribonuclease E activity
P303_01565	COG0312	modulator of DNA gyrase
P303_01580	COG0312	modulator of DNA gyrase
P303_01585	COG0583	DNA-binding transcription factor activity
P303_01600	COG1064	alcohol dehydrogenase
P303_01655	COG0356	it plays a direct role in the translocation of protons across the membrane
P303_01765	COG0201	protein transport
P303_01795	COG2960	long-chain fatty acid transporting porin activity
P303_01800	COG0606	chelatase, subunit chli
P303_01815	COG5380	lipid catabolic process
P303_01825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
P303_01850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
P303_01885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P303_01890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
P303_01905	COG1187	pseudouridine synthase activity
P303_01910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
P303_01935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P303_01945	COG0625	glutathione transferase activity
P303_01955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
P303_01995	COG0842	Transport permease protein
P303_02000	COG1131	(ABC) transporter
P303_02020	COG1643	Atp-dependent helicase
P303_02030	COG1956	GAF domain-containing protein
P303_02040	COG2911	Protein conserved in bacteria
P303_02155	COG0668	transmembrane transport
P303_02195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
P303_02230	COG2733	membrane
P303_02235	COG1253	flavin adenine dinucleotide binding
P303_02305	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
P303_02305	COG0644	oxidoreductase
P303_02320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
P303_02320	COG3218	ABC-type transport auxiliary lipoprotein component
P303_02325	COG1127	ABC transporter
P303_02330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P303_02350	COG1077	Cell shape determining protein MreB Mrl
P303_02355	COG1792	Involved in formation and maintenance of cell shape
P303_02360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
P303_02365	COG0768	penicillin binding
P303_02370	COG0772	Belongs to the SEDS family
P303_02380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P303_02400	COG2894	cell division
P303_02425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
P303_02445	COG2353	YceI-like domain
P303_02520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
P303_02525	COG4208	sulfate ABC transporter
P303_02555	COG1846	Transcriptional regulator
P303_02585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
P303_02595	COG0741	lytic transglycosylase activity
P303_02630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
P303_02670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
P303_02680	COG0514	ATP-dependent DNA helicase (RecQ)
P303_02685	COG0783	Belongs to the Dps family
P303_02690	COG1643	Atp-dependent helicase
P303_02740	COG3617	BRO family, N-terminal domain
P303_02855	COG3772	lysozyme
P303_02925	COG2944	sequence-specific DNA binding
P303_02935	COG3093	addiction module antidote protein HigA
P303_03000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
P303_03005	COG1845	cytochrome c oxidase, subunit III
P303_03010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
P303_03015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
P303_03020	COG0142	geranyltranstransferase activity
P303_03055	COG2239	Acts as a magnesium transporter
P303_03065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
P303_03100	COG1137	ATPase activity
P303_03115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
P303_03125	COG0271	Belongs to the BolA IbaG family
P303_03160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P303_03170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
P303_03190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
P303_03215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
P303_03250	COG0542	response to heat
P303_03270	COG0492	ferredoxin-NADP+ reductase activity
P303_03290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
P303_03300	COG4191	Histidine kinase
P303_03305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P303_03310	COG1028	Short-chain dehydrogenase reductase Sdr
P303_03340	COG1609	Transcriptional regulator
P303_03345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
P303_03350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
P303_03355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
P303_03365	COG0726	polysaccharide deacetylase
P303_03370	COG0297	glycogen (starch) synthase activity
P303_03390	COG0719	Fe-S assembly protein
P303_03395	COG0396	ATPase activity
P303_03400	COG0719	Fe-S assembly protein
P303_03405	COG1959	2 iron, 2 sulfur cluster binding
P303_03455	COG0308	aminopeptidase N
P303_03510	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
P303_03525	COG1758	RNA polymerase activity
P303_03535	COG1561	YicC-like family, N-terminal region
P303_03550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
P303_03600	COG5295	Hep Hag repeat protein
P303_03605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
P303_03610	COG1459	type II secretion system
P303_03620	COG2165	general secretion pathway protein
P303_03625	COG4970	Tfp pilus assembly protein FimT
P303_03630	COG2165	general secretion pathway protein
P303_03635	COG4795	General secretion pathway protein
P303_03640	COG3156	type II secretion system protein K
P303_03645	COG3166	PFAM Fimbrial assembly family protein
P303_03660	COG1450	Type ii and iii secretion system protein
P303_03670	COG0450	alkyl hydroperoxide reductase
P303_03675	COG3634	alkyl hydroperoxide reductase activity
P303_03680	COG0583	DNA-binding transcription factor activity
P303_03715	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
P303_03740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
P303_03765	COG0567	Dehydrogenase, E1 component
P303_03775	COG2850	peptidyl-arginine hydroxylation
P303_03890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P303_03895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P303_03900	COG2902	Dehydrogenase
P303_03935	COG4962	Type ii secretion system protein e
P303_03940	COG4962	Type ii secretion system protein e
P303_03960	COG3451	type IV secretory pathway VirB4
P303_04010	COG1943	Transposase
P303_04025	COG3657	addiction module killer protein
P303_04060	COG3609	addiction module antidote protein, CC2985 family
P303_04070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
P303_04090	COG2925	Exonuclease
P303_04105	COG0025	NhaP-type Na H and K H
P303_04130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
P303_04150	COG0006	proline dipeptidase activity
P303_04160	COG0778	Nitroreductase
P303_04195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
P303_04245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P303_04255	COG0557	exoribonuclease II activity
P303_04265	COG0582	viral genome integration into host DNA
P303_04270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
P303_04275	COG0302	gtp cyclohydrolase
P303_04285	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
P303_04290	COG1289	transmembrane transporter activity
P303_04320	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
P303_04330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P303_04360	COG0596	Alpha beta hydrolase
P303_04420	COG0840	transmembrane signaling receptor activity
P303_04455	COG0285	dihydrofolate synthase activity
P303_04465	COG0339	signal peptide processing
P303_04490	COG1301	dicarboxylic acid transport
P303_04505	COG2091	lysine biosynthetic process via aminoadipic acid
P303_04565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
P303_04615	COG0084	hydrolase, TatD family'
P303_04635	COG0552	protein localization to endoplasmic reticulum
P303_04675	COG0824	Thioesterase
P303_04700	COG2885	chlorophyll binding
P303_04710	COG0602	queuosine metabolic process
P303_04725	COG3104	oligopeptide transport
P303_04730	COG0386	Belongs to the glutathione peroxidase family
P303_04750	COG0406	alpha-ribazole phosphatase activity
P303_05020	COG3852	Histidine kinase
P303_05025	COG2204	response regulator
P303_05040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
P303_05045	COG0004	ammonium transporteR
P303_05050	COG0347	Belongs to the P(II) protein family
P303_05055	COG0174	glutamine synthetase
P303_05065	COG2353	YceI-like domain
P303_05205	COG3617	BRO family, N-terminal domain
P303_05280	COG3617	BRO family, N-terminal domain
P303_05315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P303_05320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
P303_05320	COG0392	lysyltransferase activity
P303_05335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
P303_05345	COG0463	Glycosyl transferase, family 2
P303_05390	COG3275	phosphorelay sensor kinase activity
P303_05395	COG0400	carboxylic ester hydrolase activity
P303_05420	COG2226	methyltransferase
P303_05445	COG2027	D-alanyl-D-alanine carboxypeptidase
P303_05450	COG2027	D-alanyl-D-alanine carboxypeptidase
P303_05500	COG0386	Belongs to the glutathione peroxidase family
P303_05505	COG1131	(ABC) transporter
P303_05645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P303_05650	COG0488	(ABC) transporter
P303_05670	COG4651	solute:proton antiporter activity
P303_05670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
P303_05735	COG0859	PFAM glycosyl transferase family 9
P303_05750	COG0631	protein serine/threonine phosphatase activity
P303_05755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
P303_05760	COG0328	RNA-DNA hybrid ribonuclease activity
P303_05780	COG2183	response to ionizing radiation
P303_05795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
P303_05805	COG3118	belongs to the thioredoxin family
P303_05850	COG2951	lytic endotransglycosylase activity
P303_05855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
P303_05905	COG3210	domain, Protein
P303_05945	COG0277	FAD linked oxidase domain protein
P303_05950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
P303_05955	COG0531	amino acid
P303_05960	COG0531	amino acid
P303_05970	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
P303_06040	COG0527	aspartate kinase activity
P303_06040	COG0460	homoserine dehydrogenase
P303_06045	COG0540	Belongs to the ATCase OTCase family
P303_06060	COG1686	Belongs to the peptidase S11 family
P303_06085	COG4953	penicillin-binding protein 1C
P303_06120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P303_06185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P303_06190	COG1506	peptidase
P303_06190	COG0823	Involved in the tonB-independent uptake of proteins
P303_06195	COG1297	OPT oligopeptide transporter protein
P303_06235	COG0676	glucose-6-phosphate 1-epimerase activity
P303_06245	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
P303_06250	COG1335	isochorismatase
P303_06255	COG0318	PFAM AMP-dependent synthetase and ligase
P303_06265	COG0463	Glycosyl transferase, family 2
P303_06280	COG1192	Involved in chromosome partitioning
P303_06340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
P303_06375	COG3316	Transposase and inactivated derivatives
P303_06390	COG0489	protein tyrosine kinase activity
P303_06400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
P303_06500	COG1605	Chorismate mutase
P303_06500	COG0077	Prephenate dehydratase
P303_06505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
P303_06515	COG1668	transmembrane transport
P303_06520	COG4555	ABC transporter
P303_06545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
P303_06555	COG1605	Chorismate mutase
P303_06555	COG0287	Prephenate dehydrogenase
P303_06590	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P303_06615	COG1278	Cold shock
P303_06650	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
P303_06670	COG0438	transferase activity, transferring glycosyl groups
P303_06740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P303_06745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P303_06760	COG1064	alcohol dehydrogenase
P303_06785	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
P303_06795	COG0436	Aminotransferase
P303_06870	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
P303_06870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
P303_06930	COG0196	riboflavin kinase activity
P303_06935	COG0728	peptidoglycan biosynthetic process
P303_06940	COG0268	Binds directly to 16S ribosomal RNA
P303_06990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
P303_07005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
P303_07030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
P303_07060	COG0395	ABC-type sugar transport system, permease component
P303_07065	COG1175	transmembrane transport
P303_07090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
P303_07110	COG0436	Aminotransferase
P303_07135	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
P303_07145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
P303_07190	COG0402	S-adenosylhomocysteine deaminase activity
P303_07200	COG1509	lysine 2,3-aminomutase activity
P303_07240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
P303_07245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
P303_07260	COG1028	Short-chain dehydrogenase reductase Sdr
P303_07305	COG0142	geranyltranstransferase activity
P303_07315	COG0037	tRNA processing
P303_07325	COG1301	dicarboxylic acid transport
P303_07335	COG0791	NLP P60 protein
P303_07350	COG2311	Membrane
P303_07365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
P303_07425	COG0352	thiamine-phosphate diphosphorylase activity
P303_07425	COG0351	phosphomethylpyrimidine kinase
P303_07435	COG1324	tolerance protein
P303_07470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P303_07475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P303_07480	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
P303_07495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
P303_07515	COG4774	siderophore transport
P303_07540	COG1477	protein flavinylation
P303_07550	COG1555	photosystem II stabilization
P303_07555	COG3178	'Phosphotransferase
P303_07560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
P303_07570	COG0628	permease
P303_07585	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
P303_07615	COG3590	peptidase
P303_07685	COG0519	Catalyzes the synthesis of GMP from XMP
P303_07685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
P303_07700	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
P303_07720	COG3107	peptidoglycan biosynthetic process
P303_07740	COG2878	Part of a membrane complex involved in electron transport
P303_07795	COG0358	DNA primase activity
P303_07825	COG0629	single-stranded DNA binding
P303_07855	COG0827	DNA restriction-modification system
P303_07860	COG0827	DNA restriction-modification system
P303_07945	COG5449	Phage conserved hypothetical protein BR0599
P303_07995	COG3772	lysozyme
P303_08015	COG0740	serine-type endopeptidase activity
P303_08045	COG0358	DNA primase activity
P303_08075	COG0629	single-stranded DNA binding
P303_08105	COG0827	DNA restriction-modification system
P303_08110	COG0827	DNA restriction-modification system
P303_08155	COG1611	Belongs to the LOG family
P303_08160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
P303_08165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
P303_08180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
P303_08210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
P303_08225	COG0330	HflC and HflK could
P303_08230	COG0330	HflC and HflK could
P303_08235	COG0604	alcohol dehydrogenase
P303_08265	COG1183	phosphatidylcholine synthase activity
P303_08285	COG0668	transmembrane transport
P303_08290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
P303_08305	COG1610	YqeY-like protein
P303_08315	COG0358	DNA primase activity
P303_08355	COG1074	ATP-dependent DNA helicase activity
P303_08360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
P303_08365	COG1127	ABC transporter
P303_08370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
P303_08390	COG2853	Lipoprotein
P303_08405	COG1116	anion transmembrane transporter activity
P303_08425	COG0531	amino acid
P303_08435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
P303_08440	COG0861	Integral membrane protein TerC family
P303_08475	COG2193	ferroxidase activity
P303_08510	COG2205	protein histidine kinase activity
P303_08515	COG0745	RESPONSE REGULATOR receiver
P303_08565	COG2194	sulfuric ester hydrolase activity
P303_08605	COG0667	Aldo Keto reductase
P303_08610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
P303_08620	COG0305	Participates in initiation and elongation during chromosome replication
P303_08640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
P303_08650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
P303_08655	COG0277	FAD linked oxidase domain protein
P303_08690	COG4206	TonB-dependent receptor
P303_08735	COG3657	addiction module killer protein
P303_08740	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P303_08770	COG3657	addiction module killer protein
P303_08775	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P303_08840	COG2369	cell adhesion
P303_08860	COG0582	viral genome integration into host DNA
P303_08865	COG3567	Phage-associated protein, HI1409 family
P303_08870	COG5410	chromosome segregation
P303_08895	COG3772	lysozyme
P303_08920	COG0305	Participates in initiation and elongation during chromosome replication
P303_08935	COG3617	BRO family, N-terminal domain
P303_09060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
P303_09110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
P303_09115	COG1764	response to oxidative stress
P303_09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
P303_09160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
P303_09170	COG1399	metal-binding, possibly nucleic acid-binding protein
P303_09180	COG0714	Associated with various cellular activities
P303_09200	COG0537	adenosine 5'-monophosphoramidase activity
P303_09260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
P303_09285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
P303_09285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
P303_09350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
P303_09365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
P303_09380	COG0251	oxidation-reduction process
P303_09580	COG3617	BRO family, N-terminal domain
P303_09655	COG3657	addiction module killer protein
P303_09660	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P303_09690	COG3657	addiction module killer protein
P303_09695	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
P303_09760	COG2369	cell adhesion
P303_09780	COG0582	viral genome integration into host DNA
P303_09785	COG3567	Phage-associated protein, HI1409 family
P303_09790	COG5410	chromosome segregation
P303_09815	COG3772	lysozyme
P303_09855	COG3617	BRO family, N-terminal domain
P303_09860	COG3617	BRO family, N-terminal domain
P303_09865	COG3617	BRO family, N-terminal domain
P303_09950	COG5532	Uncharacterized conserved protein (DUF2303)
P303_09965	COG3617	BRO family, N-terminal domain
P303_09970	COG0629	single-stranded DNA binding
P303_10015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
P303_10020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
P303_10025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
P303_10030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
P303_10050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
P303_10075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P303_10075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
P303_10095	COG0488	(ABC) transporter
P303_10105	COG3011	Protein conserved in bacteria
P303_10115	COG0564	pseudouridine synthase activity
P303_10130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
P303_10130	COG1918	ferrous iron import across plasma membrane
P303_10140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
P303_10165	COG0758	DNA mediated transformation
P303_10210	COG2969	positive regulation of protein catabolic process
P303_10215	COG0625	glutathione transferase activity
P303_10220	COG2857	Cytochrome c1
P303_10225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
P303_10230	COG0723	plastoquinol--plastocyanin reductase activity
P303_10235	COG0741	lytic transglycosylase activity
P303_10255	COG1702	phosphate starvation-inducible protein PhoH
P303_10270	COG4535	Mg2 and Co2 transporter CorC
P303_10280	COG0598	Magnesium transport protein CorA
P303_10325	COG3210	domain, Protein
P303_10345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
P303_10360	COG1199	ATP-dependent helicase activity
P303_10375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
P303_10385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
P303_10395	COG3706	GGDEF domain
P303_10410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
P303_10430	COG0742	ribosomal rna small subunit methyltransferase
P303_10440	COG0280	phosphate acetyltransferase
P303_10440	COG0281	malic enzyme
P303_10460	COG0784	Response regulator, receiver
P303_10460	COG2205	protein histidine kinase activity
P303_10475	COG0642	Histidine kinase
P303_10490	COG2851	Citrate transporter
P303_10495	COG1028	Short-chain dehydrogenase reductase Sdr
P303_10500	COG1007	ATP synthesis coupled electron transport
P303_10525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P303_10535	COG1034	ATP synthesis coupled electron transport
P303_10540	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
P303_10545	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
P303_10565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
P303_10590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
P303_10610	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
P303_10630	COG1049	propionate catabolic process, 2-methylcitrate cycle
P303_10655	COG0318	PFAM AMP-dependent synthetase and ligase
P303_10660	COG1090	epimerase
P303_10665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
P303_10685	COG0628	permease
P303_10690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
P303_10705	COG0671	phosphoesterase, PA-phosphatase related
P303_10710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
P303_10735	COG0477	Major facilitator Superfamily
P303_10770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P303_10805	COG2086	electron transfer activity
P303_10865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
P303_10870	COG0702	epimerase
P303_10875	COG1733	regulation of RNA biosynthetic process
P303_10905	COG0195	Participates in both transcription termination and antitermination
P303_10950	COG0617	tRNA 3'-terminal CCA addition
P303_10960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P303_10965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
P303_10970	COG1862	Preprotein translocase
P303_11000	COG0006	proline dipeptidase activity
P303_11040	COG0512	Glutamine amidotransferase of anthranilate synthase
P303_11105	COG0720	synthase
P303_11110	COG0513	Belongs to the DEAD box helicase family
P303_11115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
P303_11125	COG0494	nUDIX hydrolase
P303_11130	COG1218	3'(2'),5'-bisphosphate nucleotidase
P303_11135	COG3956	TIGRFAM MazG family protein
P303_11140	COG0330	HflC and HflK could
P303_11180	COG0084	hydrolase, TatD family'
P303_11185	COG0463	Glycosyl transferase, family 2
P303_11190	COG1272	protein, Hemolysin III
P303_11200	COG1028	Short-chain dehydrogenase reductase Sdr
P303_11215	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P303_11250	COG0739	heme binding
P303_11260	COG2223	nitrite transmembrane transporter activity
P303_11310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
P303_11320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
P303_11430	COG0339	signal peptide processing
P303_11445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
P303_11475	COG0367	asparagine synthase
P303_11490	COG1393	Belongs to the ArsC family
P303_11510	COG0024	Methionine aminopeptidase
P303_11540	COG1519	Transferase
P303_11545	COG1560	Kdo2-lipid A biosynthetic process
P303_11575	COG1534	Rna-binding protein
P303_11595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
P303_11610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
P303_11615	COG0477	Major facilitator Superfamily
P303_11620	COG1546	Belongs to the CinA family
P303_11625	COG3539	Fimbrial protein
P303_11630	COG3121	Chaperone
P303_11660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
P303_11670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
P303_11715	COG1752	Esterase of the alpha-beta hydrolase superfamily
P303_11725	COG1040	competence protein
P303_11755	COG0210	DNA helicase
P303_11760	COG0439	Biotin carboxylase
P303_11765	COG0511	ligase activity, forming carbon-carbon bonds
P303_11780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
P303_11790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
P303_11860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
P303_11920	COG0501	Belongs to the peptidase M48B family
P303_11930	COG0187	DNA topoisomerase II activity
P303_11945	COG0592	DNA-directed DNA polymerase activity
P303_11985	COG3210	domain, Protein
P303_12110	COG0732	type I restriction modification DNA specificity domain
P303_12190	COG0070	glutamate synthase
P303_12190	COG0067	glutamate synthase
P303_12190	COG0069	glutamate synthase activity
P303_12195	COG0493	'glutamate synthase
P303_12205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
P303_12220	COG4942	peptidase
P303_12225	COG0793	Belongs to the peptidase S41A family
P303_12235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
P303_12240	COG3118	belongs to the thioredoxin family
P303_12250	COG2884	Cell division ATP-binding protein ftsE
P303_12255	COG2177	Part of the ABC transporter FtsEX involved in
P303_12260	COG2201	protein-glutamate methylesterase activity
P303_12280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
P303_12305	COG0616	signal peptide processing
P303_12315	COG0210	DNA helicase
P303_12325	COG2132	Multicopper oxidase
P303_12360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
P303_12365	COG2095	MarC family integral membrane protein
P303_12540	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
P303_12570	COG1278	Cold shock
P303_12615	COG2197	response regulator
P303_12620	COG1530	ribonuclease E activity
P303_12625	COG0564	pseudouridine synthase activity
P303_12650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
P303_12655	COG3083	sulfuric ester hydrolase activity
P303_12660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
P303_12670	COG0473	3-isopropylmalate dehydrogenase activity
P303_12680	COG4783	chaperone-mediated protein folding
P303_12685	COG0745	RESPONSE REGULATOR receiver
P303_12710	COG1538	Outer membrane efflux protein
P303_12715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
P303_12725	COG1132	(ABC) transporter
P303_12740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
P303_12745	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
P303_12760	COG0671	phosphoesterase, PA-phosphatase related
P303_12765	COG0697	spore germination
P303_12810	COG0316	Belongs to the HesB IscA family
P303_12820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
P303_12855	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
P303_12895	COG2831	hemolysin activation secretion protein
P303_12905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit