locus-tag	class	description
XFPR_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFPR_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFPR_00025	COG0187	DNA topoisomerase II activity
XFPR_00035	COG0501	Belongs to the peptidase M48B family
XFPR_00075	COG0408	coproporphyrinogen oxidase activity
XFPR_00095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFPR_00110	COG4969	Belongs to the N-Me-Phe pilin family
XFPR_00140	COG0284	orotidine-5'-phosphate decarboxylase activity
XFPR_00175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFPR_00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFPR_00195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFPR_00200	COG0511	ligase activity, forming carbon-carbon bonds
XFPR_00205	COG0439	Biotin carboxylase
XFPR_00210	COG0210	DNA helicase
XFPR_00220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFPR_00220	COG1017	nitric oxide dioxygenase activity
XFPR_00235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFPR_00245	COG1040	competence protein
XFPR_00250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFPR_00255	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFPR_00260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFPR_00295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFPR_00310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFPR_00345	COG3121	Chaperone
XFPR_00350	COG3539	Fimbrial protein
XFPR_00355	COG1546	Belongs to the CinA family
XFPR_00360	COG0477	Major facilitator Superfamily
XFPR_00365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFPR_00370	COG1923	regulation of RNA biosynthetic process
XFPR_00375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFPR_00380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFPR_00390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFPR_00395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XFPR_00400	COG1534	Rna-binding protein
XFPR_00410	COG0129	dihydroxy-acid dehydratase activity
XFPR_00435	COG1560	Kdo2-lipid A biosynthetic process
XFPR_00440	COG1519	Transferase
XFPR_00450	COG0228	four-way junction DNA binding
XFPR_00455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFPR_00460	COG0336	Belongs to the RNA methyltransferase TrmD family
XFPR_00465	COG0335	large ribosomal subunit rRNA binding
XFPR_00470	COG0024	Methionine aminopeptidase
XFPR_00475	COG2171	N-acyltransferase activity
XFPR_00480	COG1393	Belongs to the ArsC family
XFPR_00485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFPR_00490	COG0367	asparagine synthase
XFPR_00500	COG2070	2-Nitropropane dioxygenase
XFPR_00505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFPR_00510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFPR_00515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XFPR_00530	COG0339	signal peptide processing
XFPR_00555	COG0525	valine-tRNA ligase activity
XFPR_00585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFPR_00595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFPR_00605	COG4221	oxidoreductase activity
XFPR_00615	COG0018	arginyl-trna synthetase
XFPR_00620	COG2003	Belongs to the UPF0758 family
XFPR_00625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFPR_00635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFPR_00645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFPR_00680	COG2223	nitrite transmembrane transporter activity
XFPR_00685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XFPR_00690	COG0739	heme binding
XFPR_00695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFPR_00725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFPR_00740	COG1028	Short-chain dehydrogenase reductase Sdr
XFPR_00745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFPR_00750	COG1272	protein, Hemolysin III
XFPR_00755	COG0463	Glycosyl transferase, family 2
XFPR_00760	COG0084	hydrolase, TatD family'
XFPR_00775	COG0509	glycine decarboxylation via glycine cleavage system
XFPR_00780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFPR_00790	COG0330	HflC and HflK could
XFPR_00795	COG3956	TIGRFAM MazG family protein
XFPR_00800	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFPR_00805	COG0494	nUDIX hydrolase
XFPR_00815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFPR_00820	COG0513	Belongs to the DEAD box helicase family
XFPR_00825	COG0720	synthase
XFPR_00855	COG0825	malonyl-CoA metabolic process
XFPR_00865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XFPR_00885	COG0512	Glutamine amidotransferase of anthranilate synthase
XFPR_00890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFPR_00895	COG0134	indole-3-glycerol-phosphate synthase activity
XFPR_00915	COG0006	proline dipeptidase activity
XFPR_00930	COG0343	queuine tRNA-ribosyltransferase activity
XFPR_00935	COG1862	Preprotein translocase
XFPR_00940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFPR_00945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFPR_00955	COG0617	tRNA 3'-terminal CCA addition
XFPR_00965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFPR_00970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XFPR_00975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XFPR_00980	COG0166	Belongs to the GPI family
XFPR_00995	COG0779	Required for maturation of 30S ribosomal subunits
XFPR_01000	COG0195	Participates in both transcription termination and antitermination
XFPR_01005	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFPR_01010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFPR_01015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFPR_01020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XFPR_01025	COG1185	polyribonucleotide nucleotidyltransferase activity
XFPR_01030	COG1733	regulation of RNA biosynthetic process
XFPR_01035	COG0702	epimerase
XFPR_01085	COG2086	electron transfer activity
XFPR_01115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFPR_01145	COG0477	Major facilitator Superfamily
XFPR_01160	COG0563	adenylate kinase activity
XFPR_01165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFPR_01170	COG0671	phosphoesterase, PA-phosphatase related
XFPR_01180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFPR_01185	COG0628	permease
XFPR_01205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFPR_01210	COG1090	epimerase
XFPR_01215	COG0318	PFAM AMP-dependent synthetase and ligase
XFPR_01235	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFPR_01260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFPR_01315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFPR_01325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFPR_01335	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFPR_01340	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFPR_01345	COG1034	ATP synthesis coupled electron transport
XFPR_01355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFPR_01365	COG0713	ATP synthesis coupled electron transport
XFPR_01380	COG1007	ATP synthesis coupled electron transport
XFPR_01390	COG2851	Citrate transporter
XFPR_01405	COG0642	Histidine kinase
XFPR_01420	COG0675	Transposase, IS605 OrfB family
XFPR_01450	COG4206	TonB-dependent receptor
XFPR_01455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFPR_01475	COG0277	FAD linked oxidase domain protein
XFPR_01480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFPR_01490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFPR_01510	COG0305	Participates in initiation and elongation during chromosome replication
XFPR_01525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFPR_01530	COG0667	Aldo Keto reductase
XFPR_01535	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFPR_01570	COG2194	sulfuric ester hydrolase activity
XFPR_01575	COG2124	cytochrome p450
XFPR_01580	COG0352	thiamine-phosphate diphosphorylase activity
XFPR_01590	COG0542	response to heat
XFPR_01635	COG4969	Belongs to the N-Me-Phe pilin family
XFPR_01675	COG2856	Zn peptidase
XFPR_01695	COG4197	protein conserved in bacteria, prophage-related
XFPR_01715	COG0358	DNA primase activity
XFPR_01745	COG0740	serine-type endopeptidase activity
XFPR_01760	COG3772	lysozyme
XFPR_01805	COG5449	Phage conserved hypothetical protein BR0599
XFPR_01865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFPR_01875	COG0745	RESPONSE REGULATOR receiver
XFPR_01880	COG2205	protein histidine kinase activity
XFPR_01885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFPR_01900	COG0494	nUDIX hydrolase
XFPR_01910	COG2193	ferroxidase activity
XFPR_01940	COG0861	Integral membrane protein TerC family
XFPR_01945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFPR_01950	COG0531	amino acid
XFPR_01960	COG1116	anion transmembrane transporter activity
XFPR_01965	COG1322	Protein conserved in bacteria
XFPR_01975	COG2853	Lipoprotein
XFPR_01990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFPR_01995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFPR_02000	COG1127	ABC transporter
XFPR_02005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
XFPR_02010	COG1074	ATP-dependent DNA helicase activity
XFPR_02025	COG0180	Tryptophanyl-tRNA synthetase
XFPR_02030	COG0358	DNA primase activity
XFPR_02040	COG1610	YqeY-like protein
XFPR_02045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XFPR_02050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFPR_02055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFPR_02060	COG0668	transmembrane transport
XFPR_02080	COG1183	phosphatidylcholine synthase activity
XFPR_02090	COG0442	prolyl-tRNA aminoacylation
XFPR_02115	COG0604	alcohol dehydrogenase
XFPR_02120	COG0330	HflC and HflK could
XFPR_02125	COG0330	HflC and HflK could
XFPR_02135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFPR_02140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFPR_02145	COG0105	UTP biosynthetic process
XFPR_02150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFPR_02170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFPR_02175	COG1160	GTP binding
XFPR_02180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFPR_02185	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFPR_02190	COG1611	Belongs to the LOG family
XFPR_02195	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFPR_02235	COG0675	Transposase, IS605 OrfB family
XFPR_02275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFPR_02275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFPR_02285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFPR_02290	COG3107	peptidoglycan biosynthetic process
XFPR_02300	COG1162	GTPase activity
XFPR_02305	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFPR_02315	COG0519	Catalyzes the synthesis of GMP from XMP
XFPR_02315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFPR_02330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFPR_02335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFPR_02345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFPR_02355	COG2974	May be involved in recombination
XFPR_02360	COG0037	tRNA processing
XFPR_02370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFPR_02385	COG3590	peptidase
XFPR_02405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFPR_02410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFPR_02420	COG0628	permease
XFPR_02430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFPR_02435	COG3178	'Phosphotransferase
XFPR_02440	COG1555	photosystem II stabilization
XFPR_02445	COG1477	protein flavinylation
XFPR_02465	COG3128	pkhd-type hydroxylase
XFPR_02470	COG4774	siderophore transport
XFPR_02490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFPR_02505	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFPR_02540	COG0459	protein refolding
XFPR_02550	COG1324	tolerance protein
XFPR_02560	COG0351	phosphomethylpyrimidine kinase
XFPR_02560	COG0352	thiamine-phosphate diphosphorylase activity
XFPR_02565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFPR_02665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFPR_02675	COG2311	Membrane
XFPR_02685	COG0791	NLP P60 protein
XFPR_02690	COG0791	NLP P60 protein
XFPR_02700	COG1301	dicarboxylic acid transport
XFPR_02710	COG0037	tRNA processing
XFPR_02715	COG1722	exodeoxyribonuclease VII activity
XFPR_02720	COG0142	geranyltranstransferase activity
XFPR_02765	COG1028	Short-chain dehydrogenase reductase Sdr
XFPR_02780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFPR_02785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFPR_02810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFPR_02815	COG0483	inositol monophosphate 1-phosphatase activity
XFPR_02825	COG1509	lysine 2,3-aminomutase activity
XFPR_02835	COG0402	S-adenosylhomocysteine deaminase activity
XFPR_02840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFPR_02845	COG0546	phosphoglycolate phosphatase activity
XFPR_02855	COG5434	Belongs to the glycosyl hydrolase 28 family
XFPR_02880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFPR_02885	COG1138	Cytochrome C-type biogenesis protein
XFPR_02890	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFPR_02905	COG4133	protoheme IX ABC transporter activity
XFPR_02925	COG1187	pseudouridine synthase activity
XFPR_02935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFPR_02955	COG1175	transmembrane transport
XFPR_02960	COG0395	ABC-type sugar transport system, permease component
XFPR_02990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFPR_03000	COG0776	regulation of translation
XFPR_03010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFPR_03025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFPR_03030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFPR_03040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFPR_03040	COG0519	Catalyzes the synthesis of GMP from XMP
XFPR_03055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
XFPR_03060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFPR_03065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFPR_03070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFPR_03075	COG0268	Binds directly to 16S ribosomal RNA
XFPR_03085	COG0196	riboflavin kinase activity
XFPR_03090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
XFPR_03120	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFPR_03120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFPR_03190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFPR_03210	COG1064	alcohol dehydrogenase
XFPR_03225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFPR_03230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFPR_03235	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFPR_03235	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFPR_03250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFPR_03255	COG0066	3-isopropylmalate dehydratase activity
XFPR_03260	COG0473	3-isopropylmalate dehydrogenase activity
XFPR_03290	COG0438	transferase activity, transferring glycosyl groups
XFPR_03310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFPR_03315	COG0745	RESPONSE REGULATOR receiver
XFPR_03320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFPR_03330	COG1472	Belongs to the glycosyl hydrolase 3 family
XFPR_03345	COG1278	Cold shock
XFPR_03355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XFPR_03365	COG2914	Belongs to the UPF0125 (RnfH) family
XFPR_03370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFPR_03380	COG0497	DNA recombination
XFPR_03385	COG1420	regulation of RNA biosynthetic process
XFPR_03390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFPR_03395	COG0443	Heat shock 70 kDa protein
XFPR_03400	COG0484	heat shock protein binding
XFPR_03405	COG0287	Prephenate dehydrogenase
XFPR_03405	COG1605	Chorismate mutase
XFPR_03415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFPR_03420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFPR_03425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFPR_03440	COG4555	ABC transporter
XFPR_03445	COG1668	transmembrane transport
XFPR_03460	COG1605	Chorismate mutase
XFPR_03460	COG0077	Prephenate dehydratase
XFPR_03465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFPR_03505	COG3772	lysozyme
XFPR_03520	COG0322	excinuclease ABC activity
XFPR_03525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFPR_03565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFPR_03570	COG0489	protein tyrosine kinase activity
XFPR_03575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFPR_03580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFPR_03630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFPR_03640	COG1192	Involved in chromosome partitioning
XFPR_03645	COG1475	DNA binding
XFPR_03655	COG0463	Glycosyl transferase, family 2
XFPR_03665	COG0318	PFAM AMP-dependent synthetase and ligase
XFPR_03675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFPR_03680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFPR_03685	COG0676	glucose-6-phosphate 1-epimerase activity
XFPR_03695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFPR_03715	COG1297	OPT oligopeptide transporter protein
XFPR_03725	COG1506	peptidase
XFPR_03725	COG0823	Involved in the tonB-independent uptake of proteins
XFPR_03730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFPR_03740	COG1971	Probably functions as a manganese efflux pump
XFPR_03745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFPR_03755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
XFPR_03760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFPR_03765	COG1381	Involved in DNA repair and RecF pathway recombination
XFPR_03770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFPR_03775	COG0571	ribonuclease III activity
XFPR_03790	COG0481	GTPase activity
XFPR_03795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFPR_03835	COG4953	penicillin-binding protein 1C
XFPR_03850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFPR_03860	COG1686	Belongs to the peptidase S11 family
XFPR_03865	COG1678	Uncharacterized ACR, COG1678
XFPR_03875	COG0540	Belongs to the ATCase OTCase family
XFPR_03880	COG0460	homoserine dehydrogenase
XFPR_03880	COG0527	aspartate kinase activity
XFPR_03885	COG0083	homoserine kinase activity
XFPR_03895	COG0124	histidyl-tRNA synthetase
XFPR_03905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFPR_03910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFPR_03920	COG0131	Imidazoleglycerol-phosphate dehydratase
XFPR_03920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFPR_03930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFPR_03945	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFPR_03950	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFPR_03955	COG0235	Class ii aldolase
XFPR_03960	COG0531	amino acid
XFPR_03965	COG0531	amino acid
XFPR_03970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFPR_03975	COG0277	FAD linked oxidase domain protein
XFPR_03980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFPR_04015	COG3210	domain, Protein
XFPR_04015	COG3210	domain, Protein
XFPR_04070	COG2951	lytic endotransglycosylase activity
XFPR_04095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFPR_04110	COG0495	leucyl-tRNA aminoacylation
XFPR_04120	COG3118	belongs to the thioredoxin family
XFPR_04130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFPR_04145	COG2183	response to ionizing radiation
XFPR_04155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFPR_04165	COG0328	RNA-DNA hybrid ribonuclease activity
XFPR_04170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFPR_04175	COG0631	protein serine/threonine phosphatase activity
XFPR_04190	COG0859	PFAM glycosyl transferase family 9
XFPR_04195	COG3642	lipopolysaccharide core region biosynthetic process
XFPR_04205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFPR_04210	COG2967	ApaG domain
XFPR_04215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFPR_04220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFPR_04225	COG0704	Plays a role in the regulation of phosphate uptake
XFPR_04230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFPR_04235	COG0581	inorganic phosphate transmembrane transporter activity
XFPR_04240	COG0573	inorganic phosphate transmembrane transporter activity
XFPR_04245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFPR_04250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFPR_04250	COG4651	solute:proton antiporter activity
XFPR_04260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFPR_04270	COG0488	(ABC) transporter
XFPR_04275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFPR_04305	COG0358	DNA primase activity
XFPR_04405	COG0445	tRNA wobble uridine modification
XFPR_04425	COG1469	GTP cyclohydrolase I activity
XFPR_04430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFPR_04435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFPR_04440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFPR_04450	COG2902	Dehydrogenase
XFPR_04455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFPR_04485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFPR_04490	COG1028	Short-chain dehydrogenase reductase Sdr
XFPR_04495	COG3077	Addiction module antitoxin, RelB DinJ family
XFPR_04535	COG3609	addiction module antidote protein, CC2985 family
XFPR_04600	COG2925	Exonuclease
XFPR_04615	COG0025	NhaP-type Na H and K H
XFPR_04625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFPR_04635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFPR_04650	COG3079	Belongs to the UPF0149 family
XFPR_04655	COG0006	proline dipeptidase activity
XFPR_04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFPR_04700	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFPR_04730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFPR_04735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFPR_04745	COG0557	exoribonuclease II activity
XFPR_04755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFPR_04760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFPR_04765	COG0302	gtp cyclohydrolase
XFPR_04785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFPR_04800	COG0151	Belongs to the GarS family
XFPR_04805	COG0138	bifunctional purine biosynthesis protein purh
XFPR_04815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFPR_04825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFPR_04840	COG0596	Alpha beta hydrolase
XFPR_04855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XFPR_04855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XFPR_04895	COG0840	transmembrane signaling receptor activity
XFPR_04930	COG0285	dihydrofolate synthase activity
XFPR_04940	COG0339	signal peptide processing
XFPR_04960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFPR_04965	COG1301	dicarboxylic acid transport
XFPR_04970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFPR_04975	COG0357	Ribosomal RNA small subunit methyltransferase G
XFPR_04980	COG2091	lysine biosynthetic process via aminoadipic acid
XFPR_05030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFPR_05040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFPR_05080	COG0084	hydrolase, TatD family'
XFPR_05095	COG0552	protein localization to endoplasmic reticulum
XFPR_05105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFPR_05110	COG0217	transcriptional regulatory protein
XFPR_05115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFPR_05120	COG0632	four-way junction helicase activity
XFPR_05125	COG3158	transport of potassium into the cell
XFPR_05130	COG2255	four-way junction helicase activity
XFPR_05135	COG0824	Thioesterase
XFPR_05155	COG0823	Involved in the tonB-independent uptake of proteins
XFPR_05160	COG2885	chlorophyll binding
XFPR_05170	COG0602	queuosine metabolic process
XFPR_05175	COG0588	phosphoglycerate mutase activity
XFPR_05180	COG1515	deoxyribonuclease V activity
XFPR_05185	COG3104	oligopeptide transport
XFPR_05190	COG0386	Belongs to the glutathione peroxidase family
XFPR_05210	COG0406	alpha-ribazole phosphatase activity
XFPR_05305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFPR_05310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFPR_05335	COG3852	Histidine kinase
XFPR_05340	COG2204	response regulator
XFPR_05345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFPR_05350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFPR_05355	COG0004	ammonium transporteR
XFPR_05360	COG0347	Belongs to the P(II) protein family
XFPR_05365	COG0174	glutamine synthetase
XFPR_05370	COG1968	undecaprenyl-diphosphatase activity
XFPR_05395	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFPR_05405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFPR_05430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFPR_05435	COG1764	response to oxidative stress
XFPR_05440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFPR_05450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFPR_05470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFPR_05475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFPR_05480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFPR_05485	COG1399	metal-binding, possibly nucleic acid-binding protein
XFPR_05495	COG0714	Associated with various cellular activities
XFPR_05515	COG0537	adenosine 5'-monophosphoramidase activity
XFPR_05525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFPR_05555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XFPR_05560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XFPR_05565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFPR_05590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFPR_05590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFPR_05595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFPR_05640	COG1192	Involved in chromosome partitioning
XFPR_05680	COG0629	single-stranded DNA binding
XFPR_05690	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFPR_05855	COG1064	alcohol dehydrogenase
XFPR_05865	COG4221	oxidoreductase activity
XFPR_05880	COG1028	Short-chain dehydrogenase reductase Sdr
XFPR_05885	COG2133	pyrroloquinoline quinone binding
XFPR_05915	COG1064	alcohol dehydrogenase
XFPR_05925	COG1902	pentaerythritol trinitrate reductase activity
XFPR_05930	COG0583	DNA-binding transcription factor activity
XFPR_05935	COG0667	Aldo Keto reductase
XFPR_05955	COG1942	4-Oxalocrotonate Tautomerase
XFPR_05965	COG0667	Aldo Keto reductase
XFPR_05975	COG1396	sequence-specific DNA binding
XFPR_05985	COG0582	viral genome integration into host DNA
XFPR_05995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFPR_06000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFPR_06005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFPR_06010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
XFPR_06025	COG0251	oxidation-reduction process
XFPR_06030	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFPR_06030	COG0392	lysyltransferase activity
XFPR_06045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFPR_06055	COG0463	Glycosyl transferase, family 2
XFPR_06090	COG0181	hydroxymethylbilane synthase activity
XFPR_06100	COG3275	phosphorelay sensor kinase activity
XFPR_06110	COG2943	transferase activity, transferring hexosyl groups
XFPR_06125	COG2226	methyltransferase
XFPR_06140	COG2027	D-alanyl-D-alanine carboxypeptidase
XFPR_06150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFPR_06165	COG2900	Belongs to the SlyX family
XFPR_06180	COG0386	Belongs to the glutathione peroxidase family
XFPR_06190	COG1131	(ABC) transporter
XFPR_06210	COG3657	addiction module killer protein
XFPR_06215	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFPR_06315	COG2369	cell adhesion
XFPR_06325	COG5410	chromosome segregation
XFPR_06350	COG3772	lysozyme
XFPR_06370	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFPR_06395	COG0629	single-stranded DNA binding
XFPR_06420	COG2850	peptidyl-arginine hydroxylation
XFPR_06425	COG0567	Dehydrogenase, E1 component
XFPR_06450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFPR_06465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XFPR_06470	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFPR_06475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFPR_06480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFPR_06490	COG0254	rRNA binding
XFPR_06500	COG0583	DNA-binding transcription factor activity
XFPR_06505	COG3634	alkyl hydroperoxide reductase activity
XFPR_06510	COG0450	alkyl hydroperoxide reductase
XFPR_06520	COG1450	Type ii and iii secretion system protein
XFPR_06535	COG3166	PFAM Fimbrial assembly family protein
XFPR_06540	COG3156	type II secretion system protein K
XFPR_06545	COG4795	General secretion pathway protein
XFPR_06550	COG2165	general secretion pathway protein
XFPR_06555	COG4970	Tfp pilus assembly protein FimT
XFPR_06560	COG2165	general secretion pathway protein
XFPR_06565	COG1459	type II secretion system
XFPR_06570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFPR_06575	COG5295	Hep Hag repeat protein
XFPR_06595	COG2890	protein-(glutamine-N5) methyltransferase activity
XFPR_06600	COG0596	Alpha beta hydrolase
XFPR_06615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFPR_06620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFPR_06630	COG1561	YicC-like family, N-terminal region
XFPR_06635	COG0194	GDP metabolic process
XFPR_06640	COG1758	RNA polymerase activity
XFPR_06645	COG0529	Catalyzes the synthesis of activated sulfate
XFPR_06645	COG2895	sulfate adenylyltransferase (ATP) activity
XFPR_06650	COG0175	sulfate reduction
XFPR_06660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFPR_06665	COG0175	sulfate reduction
XFPR_06680	COG2912	Transglutaminase-like superfamily
XFPR_06700	COG0308	aminopeptidase N
XFPR_06705	COG2226	methyltransferase
XFPR_06740	COG3617	BRO family, N-terminal domain
XFPR_06860	COG3772	lysozyme
XFPR_07030	COG3617	BRO family, N-terminal domain
XFPR_07150	COG3772	lysozyme
XFPR_07295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFPR_07305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFPR_07315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFPR_07330	COG1959	2 iron, 2 sulfur cluster binding
XFPR_07335	COG0719	Fe-S assembly protein
XFPR_07340	COG0396	ATPase activity
XFPR_07345	COG0719	Fe-S assembly protein
XFPR_07350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFPR_07360	COG0297	glycogen (starch) synthase activity
XFPR_07365	COG0726	polysaccharide deacetylase
XFPR_07370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFPR_07380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFPR_07385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFPR_07390	COG1609	Transcriptional regulator
XFPR_07405	COG0837	glucose binding
XFPR_07420	COG1028	Short-chain dehydrogenase reductase Sdr
XFPR_07425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFPR_07430	COG4191	Histidine kinase
XFPR_07435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFPR_07440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFPR_07445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFPR_07455	COG1674	ftsk spoiiie
XFPR_07460	COG0492	ferredoxin-NADP+ reductase activity
XFPR_07470	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFPR_07475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFPR_07480	COG0542	response to heat
XFPR_07485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFPR_07495	COG0482	sulfurtransferase activity
XFPR_07500	COG2915	High frequency lysogenization protein hflD homolog
XFPR_07510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFPR_07530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFPR_07545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFPR_07555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFPR_07595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFPR_07600	COG0271	Belongs to the BolA IbaG family
XFPR_07610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFPR_07625	COG1137	ATPase activity
XFPR_07645	COG1660	Displays ATPase and GTPase activities
XFPR_07660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFPR_07665	COG2239	Acts as a magnesium transporter
XFPR_07690	COG0629	single-stranded DNA binding
XFPR_07695	COG0142	geranyltranstransferase activity
XFPR_07700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFPR_07705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFPR_07710	COG1845	cytochrome c oxidase, subunit III
XFPR_07715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFPR_07720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFPR_07720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFPR_07735	COG1643	Atp-dependent helicase
XFPR_07740	COG0783	Belongs to the Dps family
XFPR_07745	COG0514	ATP-dependent DNA helicase (RecQ)
XFPR_07755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFPR_07765	COG0159	tryptophan synthase activity
XFPR_07770	COG0133	tryptophan synthase activity
XFPR_07775	COG0135	phosphoribosylanthranilate isomerase activity
XFPR_07780	COG0101	tRNA pseudouridine synthase activity
XFPR_07790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFPR_07800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFPR_07805	COG2890	protein-(glutamine-N5) methyltransferase activity
XFPR_07825	COG0741	lytic transglycosylase activity
XFPR_07830	COG0617	tRNA 3'-terminal CCA addition
XFPR_07835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFPR_07850	COG0156	8-amino-7-oxononanoate synthase activity
XFPR_07855	COG2267	carboxylic ester hydrolase activity
XFPR_07865	COG1846	Transcriptional regulator
XFPR_07875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFPR_07885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFPR_07890	COG4208	sulfate ABC transporter
XFPR_07895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFPR_07910	COG3142	Participates in the control of copper homeostasis
XFPR_07915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFPR_07920	COG0259	pyridoxamine-phosphate oxidase activity
XFPR_07930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFPR_07935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
XFPR_07940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFPR_07950	COG2353	YceI-like domain
XFPR_07965	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFPR_07985	COG0850	regulation of cytokinetic process
XFPR_07990	COG2894	cell division
XFPR_08010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFPR_08015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFPR_08020	COG0772	Belongs to the SEDS family
XFPR_08025	COG0768	penicillin binding
XFPR_08030	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFPR_08040	COG1077	Cell shape determining protein MreB Mrl
XFPR_08060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFPR_08065	COG1127	ABC transporter
XFPR_08070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFPR_08070	COG3218	ABC-type transport auxiliary lipoprotein component
XFPR_08085	COG0644	oxidoreductase
XFPR_08085	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFPR_08095	COG2840	Smr protein MutS2
XFPR_08100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFPR_08105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFPR_08110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFPR_08115	COG0148	phosphopyruvate hydratase activity
XFPR_08120	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFPR_08125	COG0504	CTP synthase activity
XFPR_08155	COG1253	flavin adenine dinucleotide binding
XFPR_08160	COG2733	membrane
XFPR_08180	COG2921	Belongs to the UPF0250 family
XFPR_08185	COG0321	lipoyl(octanoyl) transferase activity
XFPR_08190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFPR_08195	COG5297	Belongs to the glycosyl hydrolase family 6
XFPR_08230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFPR_08255	COG2373	Large extracellular alpha-helical protein
XFPR_08320	COG2337	Toxic component of a toxin-antitoxin (TA) module
XFPR_08395	COG2911	Protein conserved in bacteria
XFPR_08400	COG0729	surface antigen
XFPR_08405	COG1956	GAF domain-containing protein
XFPR_08410	COG1643	Atp-dependent helicase
XFPR_08430	COG1131	(ABC) transporter
XFPR_08435	COG0842	Transport permease protein
XFPR_08465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFPR_08470	COG0039	L-malate dehydrogenase activity
XFPR_08475	COG0625	glutathione transferase activity
XFPR_08480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFPR_08510	COG1187	pseudouridine synthase activity
XFPR_08525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFPR_08530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFPR_08560	COG0776	regulation of translation
XFPR_08570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFPR_08575	COG0740	serine-type endopeptidase activity
XFPR_08580	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFPR_08595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFPR_08605	COG5380	lipid catabolic process
XFPR_08615	COG0606	chelatase, subunit chli
XFPR_08620	COG2960	long-chain fatty acid transporting porin activity
XFPR_08625	COG0203	ribosomal protein L17
XFPR_08635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFPR_08640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFPR_08645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFPR_08650	COG0201	protein transport
XFPR_08655	COG0200	Binds to the 23S rRNA
XFPR_08660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFPR_08665	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XFPR_08670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFPR_08675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFPR_08680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFPR_08685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFPR_08690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XFPR_08695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFPR_08700	COG0255	Belongs to the universal ribosomal protein uL29 family
XFPR_08710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFPR_08715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFPR_08725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFPR_08730	COG0088	Forms part of the polypeptide exit tunnel
XFPR_08735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFPR_08745	COG0356	it plays a direct role in the translocation of protons across the membrane
XFPR_08755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFPR_08760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFPR_08765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFPR_08770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFPR_08775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFPR_08780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFPR_08790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFPR_08805	COG1064	alcohol dehydrogenase
XFPR_08815	COG0655	NAD(P)H dehydrogenase (quinone) activity
XFPR_08820	COG0583	DNA-binding transcription factor activity
XFPR_08825	COG0312	modulator of DNA gyrase
XFPR_08835	COG0312	modulator of DNA gyrase
XFPR_08845	COG1530	ribonuclease E activity
XFPR_08850	COG0424	maF-like protein
XFPR_08865	COG0494	nUDIX hydrolase
XFPR_08885	COG0019	diaminopimelate decarboxylase activity
XFPR_08890	COG1024	Enoyl-CoA hydratase
XFPR_08905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFPR_08910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFPR_08915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFPR_08925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFPR_08930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XFPR_08935	COG0505	Belongs to the CarA family
XFPR_08940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFPR_08965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFPR_08980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFPR_09000	COG1663	tetraacyldisaccharide 4'-kinase activity
XFPR_09005	COG1132	(ABC) transporter
XFPR_09015	COG0811	peptide transport
XFPR_09025	COG1136	(ABC) transporter
XFPR_09030	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFPR_09045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFPR_09055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFPR_09060	COG2009	succinate dehydrogenase
XFPR_09070	COG0354	folic acid binding
XFPR_09085	COG0837	glucose binding
XFPR_09090	COG0363	glucosamine-6-phosphate deaminase activity
XFPR_09125	COG0528	UMP kinase activity
XFPR_09145	COG2067	long-chain fatty acid transport protein
XFPR_09150	COG0233	cytoplasmic translational termination
XFPR_09155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFPR_09160	COG0575	Belongs to the CDS family
XFPR_09165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFPR_09170	COG0750	zinc metalloprotease
XFPR_09180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFPR_09185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFPR_09190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFPR_09195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFPR_09200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFPR_09250	COG1946	Acyl-CoA thioesterase
XFPR_09260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFPR_09265	COG1914	H( )-stimulated, divalent metal cation uptake system
XFPR_09270	COG1321	iron dependent repressor
XFPR_09275	COG0590	tRNA wobble adenosine to inosine editing
XFPR_09340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFPR_09345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFPR_09350	COG0165	Argininosuccinate lyase
XFPR_09360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFPR_09365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFPR_09370	COG0137	argininosuccinate synthase activity
XFPR_09375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFPR_09385	COG0215	cysteine-tRNA ligase activity
XFPR_09390	COG2166	iron-sulfur cluster assembly
XFPR_09405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XFPR_09410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFPR_09415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFPR_09425	COG3706	GGDEF domain
XFPR_09435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFPR_09445	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFPR_09450	COG0742	ribosomal rna small subunit methyltransferase
XFPR_09455	COG0326	Molecular chaperone. Has ATPase activity
XFPR_09460	COG0280	phosphate acetyltransferase
XFPR_09460	COG0281	malic enzyme
XFPR_09465	COG1301	dicarboxylic acid transport
XFPR_09635	COG2369	cell adhesion
XFPR_09655	COG5410	chromosome segregation
XFPR_09675	COG3772	lysozyme
XFPR_09690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFPR_09800	COG5532	Uncharacterized conserved protein (DUF2303)
XFPR_09820	COG3617	BRO family, N-terminal domain
XFPR_09830	COG0629	single-stranded DNA binding
XFPR_09850	COG0556	nucleotide-excision repair
XFPR_09865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XFPR_09875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFPR_09895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFPR_09900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFPR_09905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFPR_09920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFPR_09920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFPR_09925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFPR_09935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFPR_09940	COG0488	(ABC) transporter
XFPR_09945	COG0579	oxidoreductase
XFPR_09950	COG3011	Protein conserved in bacteria
XFPR_09965	COG0564	pseudouridine synthase activity
XFPR_09970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFPR_09990	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFPR_09990	COG1918	ferrous iron import across plasma membrane
XFPR_10005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFPR_10030	COG0758	DNA mediated transformation
XFPR_10035	COG2922	Belongs to the Smg family
XFPR_10045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFPR_10045	COG1754	DNA topoisomerase type I activity
XFPR_10050	COG0009	L-threonylcarbamoyladenylate synthase
XFPR_10080	COG2969	positive regulation of protein catabolic process
XFPR_10085	COG0625	glutathione transferase activity
XFPR_10090	COG2857	Cytochrome c1
XFPR_10095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFPR_10100	COG0723	plastoquinol--plastocyanin reductase activity
XFPR_10105	COG0741	lytic transglycosylase activity
XFPR_10110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFPR_10120	COG1702	phosphate starvation-inducible protein PhoH
XFPR_10125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFPR_10135	COG4535	Mg2 and Co2 transporter CorC
XFPR_10185	COG3210	domain, Protein
XFPR_10205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFPR_10215	COG1199	ATP-dependent helicase activity
XFPR_10225	COG0288	reversible hydration of carbon dioxide
XFPR_10240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFPR_10245	COG2011	ABC-type metal ion transport system permease component
XFPR_10250	COG1464	Belongs to the NlpA lipoprotein family
XFPR_10260	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFPR_10265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
XFPR_10280	COG0626	cystathionine gamma-synthase activity
XFPR_10285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFPR_10290	COG0739	heme binding
XFPR_10295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFPR_10300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFPR_10305	COG1238	metal cluster binding
XFPR_10320	COG5002	protein histidine kinase activity
XFPR_10325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFPR_10330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFPR_10335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFPR_10340	COG1388	LysM domain
XFPR_10340	COG3858	chitin binding
XFPR_10345	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFPR_10355	COG1472	Belongs to the glycosyl hydrolase 3 family
XFPR_10370	COG3537	Alpha-1,2-mannosidase
XFPR_10380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFPR_10385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFPR_10390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFPR_10395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFPR_10400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFPR_10410	COG0583	DNA-binding transcription factor activity
XFPR_10435	COG3588	fructose-bisphosphate aldolase
XFPR_10440	COG0469	pyruvate kinase activity
XFPR_10445	COG0126	phosphoglycerate kinase activity
XFPR_10450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFPR_10455	COG0735	belongs to the Fur family
XFPR_10465	COG5297	Belongs to the glycosyl hydrolase family 6
XFPR_10465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFPR_10470	COG0612	Peptidase, M16
XFPR_10485	COG4305	rare lipoprotein A
XFPR_10490	COG0653	protein targeting
XFPR_10495	COG0739	heme binding
XFPR_10505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFPR_10510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFPR_10520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFPR_10525	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFPR_10530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFPR_10535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFPR_10545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFPR_10550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFPR_10555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFPR_10565	COG3116	cell division
XFPR_10570	COG0275	rRNA processing
XFPR_10585	COG0471	metal ion transport
XFPR_10585	COG3273	potassium ion transport
XFPR_10590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFPR_10595	COG2022	thiamine diphosphate biosynthetic process
XFPR_10625	COG2755	lipolytic protein G-D-S-L family
XFPR_10625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFPR_10655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFPR_10680	COG3453	Protein conserved in bacteria
XFPR_10680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFPR_10685	COG0640	Transcriptional regulator
XFPR_10690	COG2391	methyltransferase activity
XFPR_10695	COG2391	methyltransferase activity
XFPR_10705	COG0717	Belongs to the dCTP deaminase family
XFPR_10715	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFPR_10720	COG0860	N-Acetylmuramoyl-L-alanine amidase
XFPR_10725	COG0802	atpase or kinase
XFPR_10730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFPR_10730	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFPR_10740	COG1570	exodeoxyribonuclease VII activity
XFPR_10765	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFPR_10780	COG0776	regulation of translation
XFPR_10785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFPR_10785	COG0072	phenylalanine-tRNA ligase activity
XFPR_10790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFPR_10795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFPR_10805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFPR_10810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFPR_10835	COG0745	RESPONSE REGULATOR receiver
XFPR_10840	COG0642	Histidine kinase
XFPR_10845	COG0237	dephospho-CoA kinase activity
XFPR_10850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFPR_10895	COG0045	succinate-CoA ligase (ADP-forming) activity
XFPR_10900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFPR_10910	COG2831	hemolysin activation secretion protein
XFPR_10925	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFPR_10935	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFPR_10945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFPR_10950	COG3115	cell septum assembly
XFPR_10960	COG0359	binds to the 23S rRNA
XFPR_10965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFPR_10980	COG0017	Asparaginyl-tRNA synthetase
XFPR_11005	COG0167	dihydroorotate dehydrogenase activity
XFPR_11010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFPR_11015	COG0697	spore germination
XFPR_11020	COG0671	phosphoesterase, PA-phosphatase related
XFPR_11025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFPR_11035	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFPR_11040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFPR_11055	COG1132	(ABC) transporter
XFPR_11060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFPR_11065	COG1538	Outer membrane efflux protein
XFPR_11070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFPR_11080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFPR_11095	COG4783	chaperone-mediated protein folding
XFPR_11105	COG0473	3-isopropylmalate dehydrogenase activity
XFPR_11115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFPR_11125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFPR_11135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFPR_11135	COG0316	Belongs to the HesB IscA family
XFPR_11140	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFPR_11150	COG0564	pseudouridine synthase activity
XFPR_11155	COG1530	ribonuclease E activity
XFPR_11160	COG2197	response regulator
XFPR_11195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFPR_11200	COG1278	Cold shock
XFPR_11210	COG0501	Belongs to the peptidase M48B family
XFPR_11215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFPR_11220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFPR_11225	COG0049	tRNA binding
XFPR_11230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XFPR_11235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFPR_11240	COG0085	RNA polymerase activity
XFPR_11245	COG0222	ribosome binding
XFPR_11250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFPR_11255	COG0081	regulation of translation
XFPR_11260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFPR_11265	COG0250	Participates in transcription elongation, termination and antitermination
XFPR_11270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFPR_11300	COG0012	GTP binding
XFPR_11305	COG0193	aminoacyl-tRNA hydrolase activity
XFPR_11315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFPR_11325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFPR_11330	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFPR_11340	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFPR_11345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFPR_11350	COG0116	Belongs to the methyltransferase superfamily
XFPR_11350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFPR_11390	COG2095	MarC family integral membrane protein
XFPR_11395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFPR_11410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFPR_11420	COG2132	Multicopper oxidase
XFPR_11430	COG0210	DNA helicase
XFPR_11435	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFPR_11440	COG0616	signal peptide processing
XFPR_11445	COG0534	Mate efflux family protein
XFPR_11465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFPR_11475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFPR_11480	COG2201	protein-glutamate methylesterase activity
XFPR_11485	COG2177	Part of the ABC transporter FtsEX involved in
XFPR_11490	COG2884	Cell division ATP-binding protein ftsE
XFPR_11495	COG0513	Belongs to the DEAD box helicase family
XFPR_11500	COG3118	belongs to the thioredoxin family
XFPR_11505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFPR_11520	COG0793	Belongs to the peptidase S41A family
XFPR_11525	COG4942	peptidase
XFPR_11535	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFPR_11540	COG0493	'glutamate synthase
XFPR_11545	COG0070	glutamate synthase
XFPR_11545	COG0069	glutamate synthase activity
XFPR_11545	COG0067	glutamate synthase
XFPR_11570	COG1028	Short-chain dehydrogenase reductase Sdr
XFPR_11595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFPR_11640	COG1280	lysine exporter protein (LysE YggA)
XFPR_11655	COG4942	peptidase
XFPR_11690	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFPR_11705	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFPR_11815	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFPR_11820	COG3657	addiction module killer protein
XFPR_11925	COG3210	domain, Protein
XFPR_11925	COG3210	domain, Protein
XFPR_11930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFPR_11940	COG0706	membrane insertase activity
XFPR_11945	COG0594	ribonuclease P activity
XFPR_11970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFPR_11990	COG3451	type IV secretory pathway VirB4
XFPR_12015	COG3736	Type IV secretory pathway, component VirB8
XFPR_12025	COG2948	multi-organism process
XFPR_12065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFPR_12085	COG3657	addiction module killer protein
XFPR_12175	COG1475	DNA binding
XFPR_12185	COG0629	single-stranded DNA binding