locus-tag	class	description
XFUD_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
XFUD_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
XFUD_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
XFUD_00025	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFUD_00035	ENOG4108K0D	peptidase, M48
XFUD_00075	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
XFUD_00100	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
XFUD_00115	ENOG4108ZUW	Major pilin subunit
XFUD_00145	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
XFUD_00150	ENOG4105CGF	Aromatic amino acid aminotransferase
XFUD_00160	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
XFUD_00175	ENOG4105D6S	protein involved in catabolism of external DNA
XFUD_00185	ENOG4108JA2	transcriptioN-repair coupling factor
XFUD_00195	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
XFUD_00200	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
XFUD_00205	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
XFUD_00210	ENOG4105C4R	Atp-dependent dna helicase
XFUD_00220	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
XFUD_00235	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
XFUD_00245	ENOG4105MJ2	Competence protein
XFUD_00250	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
XFUD_00255	ENOG4105D78	K07001 NTE family protein
XFUD_00260	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
XFUD_00295	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
XFUD_00305	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFUD_00325	ENOG4108S54	Fimbrial protein
XFUD_00340	ENOG4108VEV	chaperone
XFUD_00345	ENOG4105X0I	Fimbrial
XFUD_00350	ENOG4107TH8	cina domain protein
XFUD_00355	ENOG4105CSH	Transporter
XFUD_00360	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
XFUD_00365	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
XFUD_00370	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
XFUD_00375	ENOG4105EEI	dihydropteroate synthase
XFUD_00385	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
XFUD_00390	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
XFUD_00395	ENOG4105HBR	Rna-binding protein
XFUD_00405	ENOG4105C01	Dihydroxy-acid dehydratase
XFUD_00430	ENOG4105D1S	lipid A biosynthesis
XFUD_00435	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
XFUD_00445	ENOG4105K5M	30s ribosomal protein S16
XFUD_00450	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
XFUD_00455	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
XFUD_00460	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
XFUD_00465	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
XFUD_00470	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
XFUD_00475	ENOG4105KUZ	arsenate reductase
XFUD_00480	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
XFUD_00485	ENOG4105CAQ	asparagine synthetase
XFUD_00495	ENOG4105EA8	2-Nitropropane dioxygenase
XFUD_00500	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
XFUD_00505	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
XFUD_00510	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
XFUD_00525	ENOG4105DGW	oligopeptidase A
XFUD_00535	ENOG4105E3B	Multicopper oxidase
XFUD_00545	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
XFUD_00565	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
XFUD_00585	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
XFUD_00595	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
XFUD_00600	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
XFUD_00615	ENOG4105C75	arginyL-tRNA synthetase
XFUD_00620	ENOG4105W5Q	DNA repair protein (RadC
XFUD_00625	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
XFUD_00630	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
XFUD_00635	ENOG4107QKV	phosphomannomutase
XFUD_00645	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
XFUD_00680	ENOG4105EYM	Major Facilitator superfamily
XFUD_00685	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
XFUD_00690	ENOG4105DR5	peptidase
XFUD_00695	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
XFUD_00725	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
XFUD_00740	ENOG4105C2D	reductase
XFUD_00745	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
XFUD_00750	ENOG4108UT2	hemolysin iii
XFUD_00760	ENOG4105EYA	deoxyribonuclease
XFUD_00775	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
XFUD_00780	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
XFUD_00790	ENOG4107QX8	SPFH domain, Band 7 family protein
XFUD_00795	ENOG4105DXN	mazG family
XFUD_00800	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
XFUD_00805	ENOG4107RK2	ADP-ribose diphosphatase NudE
XFUD_00815	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
XFUD_00820	ENOG4105C1J	atp-dependent rna helicase
XFUD_00825	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
XFUD_00855	ENOG4108YXA	Membrane
XFUD_00860	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
XFUD_00865	ENOG4105C0B	DNA polymerase III (alpha subunit)
XFUD_00870	ENOG4105C8V	SAICAR synthetase
XFUD_00885	ENOG4105CRQ	synthase (Component I)
XFUD_00890	ENOG4105DDQ	anthranilate synthase
XFUD_00895	ENOG4107QYG	anthranilate phosphoribosyltransferase
XFUD_00900	ENOG4105DK0	Indole-3-glycerol phosphate synthase
XFUD_00920	ENOG4105DC7	peptidase M24
XFUD_00935	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
XFUD_00940	ENOG4105VIE	preprotein translocase, subunit YajC
XFUD_00945	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
XFUD_00960	ENOG4105DJ0	Poly(A) Polymerase
XFUD_00965	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFUD_00970	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
XFUD_00975	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
XFUD_00980	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
XFUD_00985	ENOG4107QP8	phosphohexose isomerase
XFUD_01000	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
XFUD_01005	ENOG4105CHV	Transcription elongation factor NusA
XFUD_01010	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
XFUD_01015	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
XFUD_01020	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
XFUD_01025	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
XFUD_01030	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
XFUD_01040	ENOG4105ECR	NmrA family
XFUD_01085	ENOG4105C10	Electron transfer flavoprotein
XFUD_01090	ENOG4105BZJ	Electron transfer flavoprotein
XFUD_01105	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
XFUD_01120	ENOG4107QKV	phosphomannomutase
XFUD_01150	ENOG4105CBP	Major Facilitator
XFUD_01165	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
XFUD_01170	ENOG4105DFU	Cell wall formation (By similarity)
XFUD_01175	ENOG410841Q	phosphoesterase PA-phosphatase related protein
XFUD_01185	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
XFUD_01190	ENOG4105C02	permease
XFUD_01210	ENOG4105C0H	protease
XFUD_01215	ENOG4105ECP	epimerase
XFUD_01220	ENOG4105CEY	Amp-dependent synthetase and ligase
XFUD_01225	ENOG4107QM5	aconitate hydratase
XFUD_01240	ENOG4107QIJ	Aconitate hydratase 2
XFUD_01265	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFUD_01305	ENOG4105CP7	Triose-phosphate isomerase
XFUD_01320	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFUD_01325	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFUD_01330	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFUD_01335	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFUD_01340	ENOG4105GKE	subunit e
XFUD_01345	ENOG4107QIZ	NADH dehydrogenase
XFUD_01350	ENOG4108IEH	NADH dehydrogenase subunit g
XFUD_01355	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
XFUD_01360	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFUD_01365	ENOG4105DF2	NADH dehydrogenase subunit j
XFUD_01370	ENOG41080FQ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFUD_01375	ENOG4105D65	subunit l
XFUD_01380	ENOG4105C8S	subunit m
XFUD_01385	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
XFUD_01390	ENOG4105CHR	reductase
XFUD_01395	ENOG4105D4T	Citrate transporter
XFUD_01410	ENOG4105DHQ	Histidine kinase
XFUD_01425	ENOG4105D7V	transposase
XFUD_01460	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
XFUD_01465	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFUD_01470	ENOG41080I0	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
XFUD_01480	ENOG4105CDV	Ompa motb domain protein
XFUD_01490	ENOG4105CQB	FAD linked oxidase domain protein
XFUD_01495	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
XFUD_01500	ENOG4105KME	endoribonuclease L-psp
XFUD_01505	ENOG4105CB5	ATP-dependent DNA helicase recG
XFUD_01510	ENOG4106A3M	Cytochrome p-450
XFUD_01525	ENOG4105CDU	Replicative dna helicase
XFUD_01535	ENOG4105CDV	Ompa motb domain protein
XFUD_01540	ENOG4108RVA	ribokinase
XFUD_01545	ENOG4105CPC	Aldo Keto reductase
XFUD_01550	ENOG4108JQC	penicillin-binding protein 1A
XFUD_01575	ENOG4105E4G	Type IV pilus
XFUD_01585	ENOG4105DIJ	Phosphoethanolamine transferase
XFUD_01590	ENOG4106A3M	Cytochrome p-450
XFUD_01595	ENOG4107S5G	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
XFUD_01605	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
XFUD_01620	ENOG4105UGU	tonB-dependent Receptor
XFUD_01625	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
XFUD_01635	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
XFUD_01640	ENOG4105IFJ	Histidine kinase
XFUD_01645	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
XFUD_01660	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
XFUD_01670	ENOG4108UQY	Iron-storage protein
XFUD_01700	ENOG4105DU1	integral membrane protein, terc
XFUD_01705	ENOG4105DR4	Methyltransferase
XFUD_01710	ENOG4105CUB	amino acid
XFUD_01725	ENOG4107QSV	RmuC domain protein
XFUD_01750	ENOG4107PE3	Mammalian cell entry related domain protein
XFUD_01755	ENOG4105CY3	ABC transporter, permease
XFUD_01760	ENOG4105DHJ	ABC, transporter
XFUD_01770	ENOG4107QKA	exodeoxyribonuclease V beta
XFUD_01785	ENOG4105C31	Tryptophanyl-tRNA synthetase
XFUD_01790	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFUD_01800	ENOG4105KTH	gatB Yqey
XFUD_01805	ENOG4105VCC	30S ribosomal protein S21
XFUD_01810	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
XFUD_01815	ENOG4107ZVW	dihydroneopterin aldolase
XFUD_01820	ENOG4105CUY	Mechanosensitive ion channel
XFUD_01825	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
XFUD_01840	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
XFUD_01850	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
XFUD_01870	ENOG4105M3Z	response regulator
XFUD_01880	ENOG4107QJR	hflk protein
XFUD_01885	ENOG4105EPW	hflc protein
XFUD_01895	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
XFUD_01900	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
XFUD_01905	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
XFUD_01910	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
XFUD_01930	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFUD_01935	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
XFUD_01940	ENOG4105D06	uba thif-type nad fad binding protein
XFUD_01945	ENOG41066DG	(EAL) domain protein
XFUD_01955	ENOG4106855	Competence protein
XFUD_02000	ENOG4108UUM	single-stranded DNA-binding protein
XFUD_02020	ENOG4108ZUW	Major pilin subunit
XFUD_02070	ENOG4105M03	Domain of unknown function (DUF955)
XFUD_02085	ENOG410649Z	repressor
XFUD_02090	ENOG4105W7J	DNA binding
XFUD_02110	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFUD_02160	ENOG4105KUS	lysozyme
XFUD_02270	ENOG4105D7V	transposase
XFUD_02280	ENOG4105X0D	Fimbrial protein
XFUD_02310	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
XFUD_02315	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFUD_02320	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
XFUD_02325	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
XFUD_02330	ENOG41082RQ	UPF0102 protein
XFUD_02335	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
XFUD_02340	ENOG41090JD	Blue (Type 1) copper domain protein
XFUD_02350	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
XFUD_02365	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
XFUD_02380	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
XFUD_02390	ENOG4105DH7	May be involved in recombination (By similarity)
XFUD_02395	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
XFUD_02405	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
XFUD_02420	ENOG4105C9K	Endothelin-converting enzyme 1
XFUD_02440	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
XFUD_02445	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
XFUD_02455	ENOG4105C02	permease
XFUD_02465	ENOG4108S0S	Nucleotidyl transferase
XFUD_02470	ENOG4105EHM	Aminoglycoside phosphotransferase
XFUD_02475	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
XFUD_02480	ENOG4105CJ2	(LipO)protein
XFUD_02500	ENOG4107E2E	PKHD-type hydroxylase
XFUD_02505	ENOG4108IU3	tonb-dependent siderophore receptor
XFUD_02525	ENOG4105C6T	cysteine synthase
XFUD_02540	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
XFUD_02545	ENOG4108DMA	Nad-dependent epimerase dehydratase
XFUD_02550	ENOG4108IAJ	Nad-dependent epimerase dehydratase
XFUD_02575	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
XFUD_02585	ENOG4105VF7	tolerance protein
XFUD_02590	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
XFUD_02595	ENOG4105DWF	phosphomethylpyrimidine kinase
XFUD_02600	ENOG4105E2X	shikimate dehydrogenase
XFUD_02690	ENOG4108V1T	peptidylprolyl cis-trans isomerase
XFUD_02700	ENOG4105CSM	endonuclease III
XFUD_02715	ENOG4108YZY	peptidylprolyl cis-trans isomerase
XFUD_02720	ENOG4105K4H	Nlp p60 protein
XFUD_02725	ENOG4105K4H	Nlp p60 protein
XFUD_02745	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
XFUD_02750	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
XFUD_02755	ENOG4105CTB	Polyprenyl synthetase
XFUD_02785	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
XFUD_02790	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
XFUD_02795	ENOG4105CHR	reductase
XFUD_02805	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFUD_02815	ENOG4105HHA	aminodeoxychorismate lyase
XFUD_02820	ENOG4107QRG	dna polymerase iii
XFUD_02975	ENOG4105KUS	lysozyme
XFUD_03045	ENOG41082AG	Plasmid maintenance system antidote protein
XFUD_03120	ENOG4105C22	threonyL-tRNA synthetase
XFUD_03125	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
XFUD_03135	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
XFUD_03140	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
XFUD_03145	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
XFUD_03150	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
XFUD_03165	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
XFUD_03190	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
XFUD_03200	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
XFUD_03205	ENOG4105K8N	protein family UPF0079, ATPase
XFUD_03215	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
XFUD_03225	ENOG4105DHP	deoxycytidine triphosphate deaminase
XFUD_03230	ENOG4108VCT	Sulfite exporter TauE/SafE
XFUD_03235	ENOG4105KFG	YeeE YedE family protein
XFUD_03240	ENOG4105MD1	YeeE YedE family protein
XFUD_03245	ENOG41080HT	Transcriptional regulator, arsr family
XFUD_03250	ENOG4107QPB	Beta-lactamase domain protein
XFUD_03275	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
XFUD_03305	ENOG4105EXC	Acyl-transferase
XFUD_03330	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
XFUD_03335	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
XFUD_03340	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
XFUD_03355	ENOG4108V6E	Cell division protein mraZ
XFUD_03360	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
XFUD_03365	ENOG4106932	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
XFUD_03370	ENOG4105CJN	penicillin-binding protein
XFUD_03375	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
XFUD_03380	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
XFUD_03385	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
XFUD_03395	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
XFUD_03400	ENOG4105DFU	Cell wall formation (By similarity)
XFUD_03405	ENOG4105CPF	Cell wall formation (By similarity)
XFUD_03410	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
XFUD_03415	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
XFUD_03420	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
XFUD_03425	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFUD_03435	ENOG4105DR5	peptidase
XFUD_03440	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
XFUD_03445	ENOG4108YQE	rare lipoprotein a
XFUD_03465	ENOG4106R7G	Glycoside hydrolase family 5
XFUD_03475	ENOG4105MYN	Zinc uptake regulation protein
XFUD_03480	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
XFUD_03485	ENOG4105BZA	Phosphoglycerate kinase
XFUD_03490	ENOG4105CA9	Pyruvate kinase
XFUD_03495	ENOG4107R1Y	fructose-bisphosphate aldolase
XFUD_03525	ENOG4107R11	Transcriptional regulator
XFUD_03530	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
XFUD_03535	ENOG4105D0A	hydroxylase
XFUD_03540	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
XFUD_03545	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
XFUD_03550	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
XFUD_03560	ENOG4105CWX	Alpha-1,2-mannosidase
XFUD_03585	ENOG4105E2D	ec 3.2.1.52
XFUD_03590	ENOG4105VRS	hydrolase family 18
XFUD_03595	ENOG4105E0X	reductase
XFUD_03600	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
XFUD_03605	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
XFUD_03610	ENOG4105BZU	Histidine kinase
XFUD_03620	ENOG4108K5P	(LipO)protein
XFUD_03625	ENOG4108UM1	dedA family
XFUD_03630	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
XFUD_03635	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
XFUD_03640	ENOG4105DR5	peptidase
XFUD_03645	ENOG4106TYC	homoserine o-acetyltransferase (EC 2.3.1.31)
XFUD_03650	ENOG4105C28	cystathionine
XFUD_03670	ENOG4107QSN	dihydrolipoamide acetyltransferase
XFUD_03680	ENOG4105D01	(LipO)protein
XFUD_03685	ENOG4108UMI	ABC transporter, permease
XFUD_03690	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
XFUD_03705	ENOG41077A9	carbonic anhydrase
XFUD_03715	ENOG4105DVT	helicase
XFUD_03725	ENOG4105BZ4	penicillin-binding protein
XFUD_03860	ENOG4108JU5	Magnesium and cobalt efflux protein
XFUD_03870	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
XFUD_03875	ENOG4105C9A	Phoh family
XFUD_03880	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
XFUD_03885	ENOG4105E4C	Lytic transglycosylase catalytic
XFUD_03890	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
XFUD_03895	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
XFUD_03900	ENOG4105EIX	cytochrome c1
XFUD_03910	ENOG4105KB2	stringent starvation protein b
XFUD_03945	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
XFUD_03950	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFUD_03960	ENOG4108RPN	Protein smg homolog
XFUD_03965	ENOG4105C79	DNA protecting protein DprA
XFUD_03980	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
XFUD_03985	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
XFUD_03990	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
XFUD_04005	ENOG4105CE1	Ferrous iron transport protein b
XFUD_04025	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_04030	ENOG4105C34	Pseudouridine synthase
XFUD_04035	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
XFUD_04040	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
XFUD_04045	ENOG4105DWT	malate dehydrogenase (quinone)
XFUD_04050	ENOG4105C5H	ABC transporter
XFUD_04055	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
XFUD_04065	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
XFUD_04070	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
XFUD_04080	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
XFUD_04085	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
XFUD_04090	ENOG4107YIM	Involved in the transcription termination process (By similarity)
XFUD_04095	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
XFUD_04115	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFUD_04125	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
XFUD_04140	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
XFUD_04180	ENOG4105CK2	sodium dicarboxylate symporter
XFUD_04185	ENOG4105C6K	Malic enzyme
XFUD_04190	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
XFUD_04195	ENOG4106H78	methyltransferase
XFUD_04200	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
XFUD_04210	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
XFUD_04220	ENOG4105BZU	Histidine kinase
XFUD_04230	ENOG4105CD3	dihydroorotase
XFUD_04235	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
XFUD_04240	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XFUD_04250	ENOG4105E8G	Major facilitator Superfamily
XFUD_04255	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
XFUD_04260	ENOG4105C8N	cysteinyl-tRNA synthetase
XFUD_04270	ENOG4105DBV	ornithine carbamoyltransferase
XFUD_04275	ENOG4105CDH	Citrulline--aspartate ligase
XFUD_04285	ENOG4105CAS	nag kinase
XFUD_04295	ENOG4105CH7	arginosuccinase
XFUD_04300	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
XFUD_04305	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
XFUD_04335	ENOG4105DDI	hemolysin-type calcium-binding region
XFUD_04340	ENOG4108Z6B	deaminase
XFUD_04345	ENOG4105KST	dependent repressor
XFUD_04350	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
XFUD_04355	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
XFUD_04365	ENOG4105C29	acyl-CoA thioesterase
XFUD_04390	ENOG4105E55	glycerol-3-phosphate acyltransferase
XFUD_04405	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
XFUD_04415	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
XFUD_04420	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFUD_04425	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFUD_04430	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
XFUD_04435	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
XFUD_04440	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_04445	ENOG4105DZP	Membrane-associated zinc metalloprotease
XFUD_04450	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
XFUD_04455	ENOG4105KNE	Phosphatidate cytidylyltransferase
XFUD_04460	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
XFUD_04465	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
XFUD_04470	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
XFUD_04485	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
XFUD_04510	ENOG4108UHU	Aldolase
XFUD_04515	ENOG4105C01	Dihydroxy-acid dehydratase
XFUD_04520	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
XFUD_04525	ENOG4105CHC	glucokinase (EC 2.7.1.2)
XFUD_04530	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
XFUD_04535	ENOG4108IJ9	(ABC) transporter
XFUD_04540	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
XFUD_04580	ENOG4105D60	lipoprotein releasing system transmembrane protein
XFUD_04585	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
XFUD_04590	ENOG4108EC8	DNA internalization-related competence protein ComEC
XFUD_04605	ENOG4105BZ1	(ABC) transporter
XFUD_04610	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
XFUD_04630	ENOG4107RZC	phospholipase d
XFUD_04640	ENOG4105CS1	NAD(P)H quinone oxidoreductase
XFUD_04645	ENOG4107RH7	Nicotinate phosphoribosyltransferase
XFUD_04660	ENOG4105C2M	dna polymerase I
XFUD_04670	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
XFUD_04675	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
XFUD_04680	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
XFUD_04685	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
XFUD_04695	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
XFUD_04700	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
XFUD_04705	ENOG4105CRK	lysyL-tRNA synthetase
XFUD_04710	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
XFUD_04715	ENOG4105BZU	Histidine kinase
XFUD_04720	ENOG4105E39	Enoyl-CoA hydratase
XFUD_04735	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
XFUD_04745	ENOG4105M6F	mutator MutT protein
XFUD_04750	ENOG4105SYT	Methylenetetrahydrofolate reductase
XFUD_04760	ENOG4108Z03	MAF-like protein
XFUD_04765	ENOG4105C03	ribonuclease
XFUD_04775	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
XFUD_04780	ENOG4105N42	UPF0307 protein
XFUD_04785	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
XFUD_04790	ENOG4105CC0	LysR family Transcriptional regulator
XFUD_04795	ENOG4107ZS6	Flavodoxin
XFUD_04805	ENOG4105DQ4	alcohol dehydrogenase
XFUD_04820	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
XFUD_04830	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
XFUD_04835	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
XFUD_04840	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
XFUD_04845	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
XFUD_04850	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFUD_04855	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFUD_04860	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
XFUD_04865	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
XFUD_04875	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
XFUD_04880	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
XFUD_04885	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
XFUD_04890	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFUD_04895	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
XFUD_04900	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
XFUD_04905	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
XFUD_04915	ENOG41083MP	50s ribosomal protein l29
XFUD_04920	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
XFUD_04925	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
XFUD_04930	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
XFUD_04935	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFUD_04940	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
XFUD_04945	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
XFUD_04950	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
XFUD_04955	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
XFUD_04960	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
XFUD_04965	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
XFUD_04970	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFUD_04975	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
XFUD_04980	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
XFUD_04990	ENOG4108ZT0	50S ribosomal protein l17
XFUD_04995	ENOG4105W0Z	cytoplasmic protein
XFUD_05000	ENOG4105C0P	Mg chelatase subunit ChlI
XFUD_05010	ENOG4105MGK	May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity)
XFUD_05020	ENOG4107QQG	Dehydrogenase
XFUD_05035	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
XFUD_05040	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
XFUD_05045	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
XFUD_05055	ENOG4105K70	DNA-binding protein
XFUD_05070	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
XFUD_05085	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
XFUD_05090	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
XFUD_05105	ENOG4105I08	Pseudouridine synthase
XFUD_05135	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
XFUD_05140	ENOG4108K3A	Glutathione S-transferase
XFUD_05145	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
XFUD_05150	ENOG4107XH4	PPIases accelerate the folding of proteins (By similarity)
XFUD_05155	ENOG4105CI3	gtp-binding protein typa
XFUD_05165	ENOG4108MBX	Secretion Protein
XFUD_05185	ENOG4105DA5	(ABC) transporter
XFUD_05205	ENOG4105CQ7	ATP-dependent helicase
XFUD_05215	ENOG4105CFU	surface antigen
XFUD_05220	ENOG4105MA0	exported protein
XFUD_05225	ENOG4105CR4	methylisocitrate lyase
XFUD_05265	ENOG4105C7F	AcnD-accessory protein PrpF
XFUD_05295	ENOG4105DN3	alpha-2-macroglobulin domain protein
XFUD_05320	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
XFUD_05335	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
XFUD_05360	ENOG41065HY	1,4-beta-cellobiosidase
XFUD_05365	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
XFUD_05370	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
XFUD_05395	ENOG4106BRA	Membrane
XFUD_05420	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFUD_05430	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
XFUD_05435	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
XFUD_05440	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
XFUD_05445	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
XFUD_05450	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
XFUD_05455	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
XFUD_05460	ENOG4108DG9	Smr protein MutS2
XFUD_05470	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
XFUD_05485	ENOG4108SNX	Mammalian cell entry related domain protein
XFUD_05490	ENOG4105DHJ	ABC, transporter
XFUD_05515	ENOG4105DFF	Rod shape-determining protein mreb
XFUD_05530	ENOG4105CJN	penicillin-binding protein
XFUD_05535	ENOG4105CNI	cell division protein FtsW
XFUD_05540	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
XFUD_05545	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
XFUD_05565	ENOG4107QMS	site-determining protein
XFUD_05570	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
XFUD_05600	ENOG4108VKM	cytochrome b561
XFUD_05605	ENOG4108YYC	ycei family
XFUD_05615	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
XFUD_05625	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
XFUD_05635	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
XFUD_05640	ENOG4105CX6	glutaminyL-tRNA synthetase
XFUD_05660	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
XFUD_05665	ENOG4108I5D	sulfate abc transporter
XFUD_05675	ENOG4108IJ6	ABC transporter
XFUD_05685	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
XFUD_05690	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFUD_05695	ENOG4105NTK	Transcriptional repressor Mpra
XFUD_05705	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
XFUD_05710	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
XFUD_05720	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
XFUD_05725	ENOG4107U32	Beta-lactamase domain protein
XFUD_05730	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
XFUD_05735	ENOG4107SC1	transglycosylase
XFUD_05745	ENOG4105DJ4	phosphatidylserine decarboxylase
XFUD_05755	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
XFUD_05760	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
XFUD_05765	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
XFUD_05775	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
XFUD_05780	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
XFUD_05785	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
XFUD_05790	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
XFUD_05795	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
XFUD_05800	ENOG4108M8W	Monooxygenase
XFUD_05805	ENOG4105C9U	ATP-dependent DNA helicase RecQ
XFUD_05815	ENOG4105CQ7	ATP-dependent helicase
XFUD_05830	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFUD_05835	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
XFUD_05840	ENOG4105CCU	oxidase (Subunit III)
XFUD_05845	ENOG4105BZ9	Cytochrome C oxidase, subunit I
XFUD_05850	ENOG4105E2S	oxidase) subunit II
XFUD_05855	ENOG4105EAH	synthase
XFUD_05860	ENOG4108UUM	single-stranded DNA-binding protein
XFUD_05865	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
XFUD_05885	ENOG4105CJW	magnesium transporter
XFUD_05890	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
XFUD_05895	ENOG41080Z8	PHOSPHOCARRIER protein
XFUD_05905	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
XFUD_05915	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
XFUD_05920	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
XFUD_05925	ENOG4108IUZ	ABC transporter
XFUD_05940	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
XFUD_05945	ENOG4105C2X	Arabinose 5-phosphate isomerase
XFUD_05955	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
XFUD_05990	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
XFUD_05995	ENOG4105T95	Thiol disulfide interChange protein
XFUD_06000	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
XFUD_06005	ENOG4105EYW	Ion transport protein
XFUD_06010	ENOG4105C8Y	Acetylornithine aminotransferase
XFUD_06020	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
XFUD_06040	ENOG4108Z33	Thiol disulfide Interchange Protein
XFUD_06045	ENOG4108Z33	Thiol disulfide Interchange Protein
XFUD_06055	ENOG41075W9	High frequency lysogenization protein HflD homolog
XFUD_06070	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
XFUD_06075	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
XFUD_06080	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
XFUD_06085	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
XFUD_06095	ENOG4105C3M	thioredoxin reductase
XFUD_06100	ENOG4105CNU	cell division protein FtsK
XFUD_06110	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
XFUD_06115	ENOG4105D1H	recombination factor protein RarA
XFUD_06120	ENOG4105WMR	Protein CrcB homolog
XFUD_06125	ENOG4105BZU	Histidine kinase
XFUD_06135	ENOG4105CAN	Short-chain dehydrogenase reductase Sdr
XFUD_06150	ENOG4105CHC	glucokinase (EC 2.7.1.2)
XFUD_06165	ENOG4105ETE	Transcriptional regulator (LacI family
XFUD_06170	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
XFUD_06175	ENOG4105CE4	GlcNAc 6-P deacetylase
XFUD_06180	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
XFUD_06185	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
XFUD_06190	ENOG4107BJW	polysaccharide deacetylase
XFUD_06195	ENOG4107QPH	glycogen) synthase
XFUD_06205	ENOG4105C9B	Cysteine desulfurase
XFUD_06215	ENOG4105C3K	feS assembly ATPase SufC
XFUD_06240	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
XFUD_06260	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
XFUD_06270	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFUD_06275	ENOG4105CD8	aminopeptidase N
XFUD_06300	ENOG41063JG	Transcriptional regulator
XFUD_06315	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
XFUD_06320	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
XFUD_06330	ENOG4105C11	sulfate adenylyltransferase), subunit 2
XFUD_06335	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
XFUD_06340	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
XFUD_06345	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
XFUD_06350	ENOG4105DSJ	YicC domain protein
XFUD_06355	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
XFUD_06360	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
XFUD_06365	ENOG4105CSA	Coproporphyrinogen iii oxidase
XFUD_06380	ENOG4108HGY	Proline imino-peptidase
XFUD_06385	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
XFUD_06405	ENOG4105EUR	Domain-Containing protein
XFUD_06410	ENOG4107QHF	type ii secretion system protein e
XFUD_06415	ENOG4105D7Q	type ii secretion system
XFUD_06425	ENOG4105WMT	general secretion pathway protein h
XFUD_06435	ENOG41069G9	General secretion pathway protein J
XFUD_06440	ENOG4105UV2	general secretion pathway protein K
XFUD_06445	ENOG41090VX	general secretion pathway protein L
XFUD_06450	ENOG410678M	general secretion pathway protein M
XFUD_06460	ENOG4105GVR	general secretion pathway protein D
XFUD_06470	ENOG4105D3R	alkyl hydroperoxide reductase
XFUD_06480	ENOG4105C5Q	Transcriptional regulator
XFUD_06485	ENOG41072GX	Peptidase M22 Glycoprotease
XFUD_06490	ENOG4105NRA	50s ribosomal protein l31 type b
XFUD_06495	ENOG4105BZN	citrate synthase
XFUD_06500	ENOG4108UJD	30S ribosomal protein S9
XFUD_06505	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
XFUD_06510	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
XFUD_06515	ENOG4105FDS	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
XFUD_06530	ENOG4105CUZ	uba thif-type nad fad binding protein
XFUD_06550	ENOG4105C7S	Dehydrogenase
XFUD_06555	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
XFUD_06560	ENOG4105EZE	Cupin 4 family protein
XFUD_06565	ENOG4107QTF	adenylosuccinate lyase
XFUD_06575	ENOG4105C9Q	fumarate hydratase class II
XFUD_06585	ENOG4108UUM	single-stranded DNA-binding protein
XFUD_06605	ENOG4106FAK	Endodeoxyribonuclease RusA
XFUD_06625	ENOG4105KUS	lysozyme
XFUD_06675	ENOG4108C66	Inherit from COG: DNA primase
XFUD_06710	ENOG4106GMR	
XFUD_06730	ENOG4106GZK	Protein of unknown function (DUF2669)
XFUD_06780	ENOG4105YES	addiction module antidote protein
XFUD_06785	ENOG4105VUH	addiction module killer protein
XFUD_06805	ENOG4105CZV	ABC transporter
XFUD_06810	ENOG4108V06	Glutathione peroxidase
XFUD_06820	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
XFUD_06840	ENOG4105D7K	pfkb domain protein
XFUD_06850	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
XFUD_06865	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
XFUD_06880	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
XFUD_06890	ENOG4108HRK	Histidine kinase
XFUD_06895	ENOG4108NEV	two component transcriptional regulator, LytTR family
XFUD_06900	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
XFUD_06915	ENOG4105CZX	twitching motility protein
XFUD_06920	ENOG4105CZX	twitching motility protein
XFUD_06935	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
XFUD_06945	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
XFUD_06965	ENOG4108J6E	Pfam:Phage_integr_N
XFUD_06970	ENOG4108UUM	single-stranded DNA-binding protein
XFUD_06995	ENOG4108HJ1	Uncharacterized conserved protein (DUF2303)
XFUD_07000	ENOG4105H40	
XFUD_07100	ENOG4106FAK	Endodeoxyribonuclease RusA
XFUD_07115	ENOG4105KUS	lysozyme
XFUD_07170	ENOG4108C66	Inherit from COG: DNA primase
XFUD_07205	ENOG4106GMR	
XFUD_07225	ENOG4106GZK	Protein of unknown function (DUF2669)
XFUD_07275	ENOG4105YES	addiction module antidote protein
XFUD_07280	ENOG4105VUH	addiction module killer protein
XFUD_07320	ENOG4105M4H	endoribonuclease L-psp
XFUD_07340	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
XFUD_07345	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
XFUD_07350	ENOG4105DFA	alanine racemase domain protein
XFUD_07360	ENOG4105DFP	Integrase
XFUD_07380	ENOG4105CPC	Aldo Keto reductase
XFUD_07385	ENOG4105CPC	Aldo Keto reductase
XFUD_07390	ENOG4105VW8	4-oxalocrotonate tautomerase
XFUD_07410	ENOG4107S5I	aldo keto reductase
XFUD_07415	ENOG4105HEI	LysR family (Transcriptional regulator
XFUD_07420	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
XFUD_07430	ENOG4105DQ4	alcohol dehydrogenase
XFUD_07435	ENOG4105D8V	Glucose sorbosone dehydrogenase
XFUD_07460	ENOG4105D8V	Glucose sorbosone dehydrogenase
XFUD_07465	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
XFUD_07470	ENOG4108TY5	Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis
XFUD_07480	ENOG4105EMU	Dehydrogenase
XFUD_07485	ENOG4105ENX	hydrolase
XFUD_07490	ENOG4105DQ4	alcohol dehydrogenase
XFUD_07505	ENOG4107RTG	Major Facilitator superfamily
XFUD_07510	ENOG4105ENX	hydrolase
XFUD_07520	ENOG4105EQ2	LysR family Transcriptional regulator
XFUD_07610	ENOG4105EQ2	LysR family Transcriptional regulator
XFUD_07655	ENOG4105NI8	Cytosine-specific methyltransferase
XFUD_07665	ENOG4107YH6	single-stranded DNA-binding protein
XFUD_07705	ENOG4107QJE	Chromosome Partitioning Protein
XFUD_07750	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
XFUD_07755	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
XFUD_07780	ENOG4107YZP	Rhodanese domain protein
XFUD_07785	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
XFUD_07790	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
XFUD_07815	ENOG4107QMP	dna polymerase iii subunits gamma and tau
XFUD_07820	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
XFUD_07825	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
XFUD_07830	ENOG4105K59	histidine triad (HIT) protein
XFUD_07840	ENOG4105F8C	transglutaminase domain-containing protein
XFUD_07850	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
XFUD_07860	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
XFUD_07865	ENOG4105VGS	50s ribosomal protein l32
XFUD_07870	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
XFUD_07875	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
XFUD_07880	ENOG4105C7B	Threonine dehydratase
XFUD_07895	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
XFUD_07900	ENOG4105CN1	protease
XFUD_07905	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
XFUD_07910	ENOG4108ZHJ	Organic hydroperoxide resistance protein
XFUD_07915	ENOG4105D6Z	AFG1 family ATPase
XFUD_07940	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
XFUD_07950	ENOG4105RKW	reductase (By
XFUD_07975	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
XFUD_07980	ENOG4105C5F	glutamine synthetase
XFUD_07990	ENOG4105BZU	Histidine kinase
XFUD_07995	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
XFUD_08000	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
XFUD_08005	ENOG4105CUX	Signal transduction histidine kinase
XFUD_08030	ENOG4107GFK	fumarate
XFUD_08035	ENOG4105C9M	aspartyl-trna synthetase
XFUD_08040	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
XFUD_08060	ENOG4105NFY	transcriptional modulator of maze toxin, mazf
XFUD_08155	ENOG4105CVJ	phosphoglycerate mutase
XFUD_08170	ENOG4105DP0	ferredoxin-NADP reductase
XFUD_08175	ENOG4108V06	Glutathione peroxidase
XFUD_08180	ENOG4105DUX	Transporter
XFUD_08185	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
XFUD_08190	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
XFUD_08195	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
XFUD_08205	ENOG4105KCK	Peptidoglycan-associated lipoprotein
XFUD_08210	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
XFUD_08220	ENOG4105M8F	Biopolymer transport protein exbD tolR
XFUD_08225	ENOG4105E02	MotA TolQ exbB proton channel
XFUD_08230	ENOG4107YD3	Thioesterase
XFUD_08235	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
XFUD_08240	ENOG4105DFH	Transport of potassium into the cell (By similarity)
XFUD_08245	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
XFUD_08250	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
XFUD_08255	ENOG4105CDY	transcriptional regulatory protein
XFUD_08260	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
XFUD_08265	ENOG4105CEN	a g-specific adenine glycosylase
XFUD_08270	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
XFUD_08285	ENOG4105F8V	Hydrolase, tatD family
XFUD_08325	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFUD_08335	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
XFUD_08340	ENOG4108IYU	L-aspartate oxidase
XFUD_08345	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
XFUD_08390	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
XFUD_08395	ENOG4105CV1	Transketolase (EC 2.2.1.1)
XFUD_08400	ENOG4105CK2	sodium dicarboxylate symporter
XFUD_08405	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
XFUD_08425	ENOG4105DGW	oligopeptidase A
XFUD_08435	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
XFUD_08450	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
XFUD_08465	ENOG4105CBS	Chea signal transduction histidine kinase
XFUD_08470	ENOG4105C8Q	Methyl-accepting chemotaxis
XFUD_08475	ENOG4108ZGA	chew protein
XFUD_08480	ENOG4108UNF	response regulator
XFUD_08485	ENOG4105D7Z	glutathione synthase
XFUD_08500	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
XFUD_08505	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
XFUD_08510	ENOG4105C4K	Nad synthetase
XFUD_08520	ENOG4105PI0	Ferredoxin
XFUD_08525	ENOG4108J2P	Alpha beta hydrolase fold
XFUD_08535	ENOG4107QMH	DNA methylase
XFUD_08540	ENOG4105E2T	synthase III
XFUD_08550	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
XFUD_08560	ENOG4105DC1	bifunctional purine biosynthesis protein purh
XFUD_08565	ENOG4105C12	Phosphoribosylglycinamide synthetase
XFUD_08575	ENOG4105EM2	membrane
XFUD_08580	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
XFUD_08595	ENOG4105EUJ	GTP cyclohydrolase i
XFUD_08600	ENOG4108Z0R	Transferase
XFUD_08605	ENOG4105C2N	RNA methyltransferase TrmH family group 3
XFUD_08625	ENOG4107ZT5	Thiol disulfide interchange protein
XFUD_08630	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
XFUD_08640	ENOG4106WTF	Glycosyl transferase, family 2
XFUD_08660	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
XFUD_08665	ENOG4105CM2	brancheD-chain amino acid aminotransferase
XFUD_08705	ENOG4107RAQ	aminopeptidase
XFUD_08720	ENOG4105W8B	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
XFUD_08725	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
XFUD_08735	ENOG4105E66	phosphoriboisomerase A
XFUD_08745	ENOG4105EEQ	Na H antiporter
XFUD_08760	ENOG4105CJB	Exodeoxyribonuclease I
XFUD_08785	ENOG4108C33	Resolvase
XFUD_08945	ENOG4108IYH	Dna topoisomerase
XFUD_09005	ENOG4105X54	addiction module antidote protein
XFUD_09015	ENOG4105C26	Dehydrogenase
XFUD_09050	ENOG4105CHR	reductase
XFUD_09055	ENOG4105BZS	acriflavin resistance protein
XFUD_09085	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
XFUD_09100	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
XFUD_09105	ENOG4105BZS	acriflavin resistance protein
XFUD_09110	ENOG4108Z0R	Transferase
XFUD_09115	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
XFUD_09135	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
XFUD_09225	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
XFUD_09260	ENOG4105C5H	ABC transporter
XFUD_09265	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
XFUD_09270	ENOG4107ZXU	DSBA oxidoreductase
XFUD_09275	ENOG4107RNH	Outer membrane receptor FepA
XFUD_09285	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
XFUD_09290	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
XFUD_09295	ENOG4105C8U	phosphate abc transporter
XFUD_09300	ENOG4105E2Z	phosphate ABC transporter (Permease
XFUD_09305	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
XFUD_09310	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
XFUD_09315	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
XFUD_09320	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
XFUD_09325	ENOG4105NWN	ApaG protein
XFUD_09330	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
XFUD_09340	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
XFUD_09345	ENOG4105DKP	glycosyl transferase, family 9
XFUD_09360	ENOG4108ZF3	Phosphatase
XFUD_09365	ENOG4107RZZ	dna polymerase iii epsilon subunit
XFUD_09370	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
XFUD_09380	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
XFUD_09385	ENOG4105BZM	domain protein
XFUD_09400	ENOG4105F0N	pyrophosphate phospho-hydrolase
XFUD_09405	ENOG4105K63	Thioredoxin
XFUD_09415	ENOG4105C8T	Leucyl-tRNA synthetase
XFUD_09430	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
XFUD_09455	ENOG4105CVE	Lytic murein transglycosylase
XFUD_09460	ENOG4105K6T	rare lipoprotein A
XFUD_09590	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
XFUD_09600	ENOG4105FUQ	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
XFUD_09605	ENOG4105CQB	FAD linked oxidase domain protein
XFUD_09610	ENOG4108JQ1	Dehydrogenase
XFUD_09615	ENOG4105CUB	amino acid
XFUD_09620	ENOG4105CUB	amino acid
XFUD_09625	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
XFUD_09630	ENOG4108CAF	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)
XFUD_09635	ENOG4106YVY	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)
XFUD_09640	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
XFUD_09645	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
XFUD_09650	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
XFUD_09655	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
XFUD_09660	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
XFUD_09665	ENOG4105CIH	Imidazole acetol-phosphate transaminase
XFUD_09670	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
XFUD_09675	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
XFUD_09685	ENOG4105CUT	histidyl-tRNA synthetase
XFUD_09695	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
XFUD_09700	ENOG4105CFH	Aspartokinase
XFUD_09705	ENOG4105CXT	aspartate transcarbamylase
XFUD_09715	ENOG4108UJU	UPF0301 protein
XFUD_09720	ENOG4105DZ1	carboxypeptidase
XFUD_09730	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
XFUD_09745	ENOG4108JQB	penicillin-binding protein 1C
XFUD_09760	ENOG4105EMN	RNA polymerase sigma factor
XFUD_09770	ENOG4105C0H	protease
XFUD_09775	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
XFUD_09780	ENOG4105C3F	Signal peptidase i
XFUD_09790	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
XFUD_09795	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
XFUD_09800	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
XFUD_09805	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
XFUD_09820	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
XFUD_09840	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
XFUD_09845	ENOG4105EPD	Oligopeptide transporter, Opt family
XFUD_09855	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
XFUD_09860	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
XFUD_09865	ENOG4107QVN	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
XFUD_09875	ENOG4105DSB	aldose 1-epimerase
XFUD_09880	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
XFUD_09885	ENOG4105WPN	DNA integration recombination invertion protein
XFUD_09895	ENOG410680H	amp-dependent synthetase and ligase
XFUD_09915	ENOG4105FA0	parb-like partition protein
XFUD_09920	ENOG4107QJE	Chromosome Partitioning Protein
XFUD_09930	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
XFUD_09990	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
XFUD_09995	ENOG4105D1F	ATP-binding protein
XFUD_10000	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
XFUD_10015	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
XFUD_10020	ENOG4105D52	delta-aminolevulinic acid dehydratase
XFUD_10040	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
XFUD_10045	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
XFUD_10060	ENOG4105KUS	lysozyme
XFUD_10095	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
XFUD_10105	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
XFUD_10115	ENOG4108SDH	ABC, transporter
XFUD_10120	ENOG4108IUW	ABC transporter
XFUD_10135	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
XFUD_10140	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
XFUD_10145	ENOG41080IJ	Diacylglycerol kinase
XFUD_10150	ENOG4105ETX	regulatoR
XFUD_10165	ENOG4105CFG	Acts as a chaperone (By similarity)
XFUD_10170	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFUD_10175	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
XFUD_10180	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
XFUD_10185	ENOG41090R7	Ferric uptake
XFUD_10190	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
XFUD_10205	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
XFUD_10215	ENOG4105VEQ	Cold shock protein
XFUD_10220	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
XFUD_10225	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
XFUD_10235	ENOG41080ZE	Adenylate cyclase
XFUD_10240	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
XFUD_10245	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
XFUD_10250	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
XFUD_10255	ENOG4108NQK	Catalyzes the transfer of a glucuronic acid (GlcA) residue from UDP-glucuronate to mannose-alpha-1,3-glucose-beta- 1,4-glucose-P-P-polyisoprenyl to form the lipid-linked tetrasaccharide GlcA-Man-Glc(2)-PP-Pol, with a glucuronic acid- beta-mannose linkage. Is involved in the biosynthesis of the exopolysaccharide xanthan, since it catalyzes the fourth glycosylation step in the assembly of the pentasaccharide-P-P- polyisoprenyl repeating unit of xanthan. Is unable to use the trisaccharide acceptor freed from the pyrophosphate lipid moiety. Does not show specificity for the lipidic portion of the acceptor. Shows diminished activity when tested with 6-O-acetyl-mannose- alpha-1,3-glucose-beta-1,4-glucose-P-P-polyisoprenyl, a
XFUD_10270	ENOG4107UFF	group 1 glycosyl transferase
XFUD_10285	ENOG4105D3Q	Sugar transferase
XFUD_10300	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
XFUD_10305	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
XFUD_10310	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
XFUD_10325	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
XFUD_10330	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
XFUD_10335	ENOG4105BZS	acriflavin resistance protein
XFUD_10350	ENOG4105DQ4	alcohol dehydrogenase
XFUD_10380	ENOG4108JJA	ABC, transporter
XFUD_10385	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
XFUD_10465	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
XFUD_10475	ENOG4105DTN	riboflavin biosynthesis protein ribF
XFUD_10480	ENOG4105CJR	Integral membrane protein (MviN
XFUD_10485	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
XFUD_10490	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFUD_10495	ENOG4105K46	50S ribosomal protein l27
XFUD_10500	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
XFUD_10520	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
XFUD_10525	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
XFUD_10530	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
XFUD_10535	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
XFUD_10550	ENOG4105CFV	Tetratricopeptide repeat protein
XFUD_10560	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
XFUD_10565	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
XFUD_10570	ENOG4105CAT	Cytidine monophosphate kinase
XFUD_10580	ENOG4105DWY	Agmatine deiminase
XFUD_10600	ENOG4105DRS	transport system, permease
XFUD_10605	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
XFUD_10625	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
XFUD_10635	ENOG4105FE9	pseudouridine synthase
XFUD_10650	ENOG4105CHM	Aminotransferase
XFUD_10655	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
XFUD_10660	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
XFUD_10665	ENOG41060IM	Heme exporter protein
XFUD_10670	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
XFUD_10675	ENOG4105DA4	cytochrome c-type biogenesis protein
XFUD_10680	ENOG4107QX9	Thiol disulfide interChange protein
XFUD_10685	ENOG4105KWW	Biogenesis protein
XFUD_10700	ENOG4105DWV	Homoserine O-trans-acetylase
XFUD_10715	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
XFUD_10720	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
XFUD_10725	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
XFUD_10735	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
XFUD_10745	ENOG4105ECY	inositol monophosphatase
XFUD_10750	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
XFUD_10815	ENOG4105RT5	Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation
XFUD_10820	ENOG4105WJ3	XRE family Transcriptional regulator
XFUD_10890	ENOG4105KUS	lysozyme
XFUD_11040	ENOG4108I1J	Integrase
XFUD_11055	ENOG4105ETX	regulatoR
XFUD_11065	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
XFUD_11070	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
XFUD_11090	ENOG4105X0D	Fimbrial protein
XFUD_11100	ENOG4107QHF	type ii secretion system protein e
XFUD_11105	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
XFUD_11110	ENOG4107TUY	Histidine kinase
XFUD_11115	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
XFUD_11120	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
XFUD_11130	ENOG4105D5K	Hemolysin activator protein
XFUD_11140	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
XFUD_11145	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
XFUD_11155	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
XFUD_11165	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
XFUD_11170	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
XFUD_11180	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
XFUD_11185	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
XFUD_11195	ENOG4108Z4V	iron-sulfur cluster assembly
XFUD_11200	ENOG4105C5S	asparaginyl-tRNA synthetase
XFUD_11225	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
XFUD_11230	ENOG4105D4A	Cell wall formation (By similarity)
XFUD_11235	ENOG4108SXK	Transporter Drug Metabolite Exporter family
XFUD_11240	ENOG410841Q	phosphoesterase PA-phosphatase related protein
XFUD_11245	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
XFUD_11260	ENOG4108UYB	regulatoR
XFUD_11265	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
XFUD_11280	ENOG4105BZ1	(ABC) transporter
XFUD_11285	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
XFUD_11290	ENOG4105DFG	type I secretion outer membrane protein
XFUD_11295	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
XFUD_11300	ENOG4105C9X	ppx gppa phosphatase
XFUD_11305	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
XFUD_11310	ENOG4105BZU	Histidine kinase
XFUD_11315	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
XFUD_11320	ENOG4105ERG	peptidase m48, ste24p
XFUD_11325	ENOG4105VW4	glutaredoxin 3
XFUD_11330	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
XFUD_11340	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
XFUD_11350	ENOG4108Z4U	Ferredoxin
XFUD_11360	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
XFUD_11365	ENOG41090A4	Pterin carbinolamine dehydratase
XFUD_11375	ENOG4105EI2	Pseudouridine synthase
XFUD_11380	ENOG4105C03	ribonuclease
XFUD_11390	ENOG4105C72	UPF0176 protein
XFUD_11400	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
XFUD_11415	ENOG4105C5H	ABC transporter
XFUD_11420	ENOG4105CNG	UPF0061 protein
XFUD_11435	ENOG4105D0M	Protease HtpX homolog
XFUD_11440	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
XFUD_11445	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
XFUD_11450	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
XFUD_11455	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
XFUD_11460	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
XFUD_11465	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
XFUD_11470	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
XFUD_11475	ENOG4108VZM	50s ribosomal protein L10
XFUD_11480	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
XFUD_11485	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
XFUD_11490	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
XFUD_11495	ENOG4105PM1	preprotein translocase subunit SecE
XFUD_11505	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
XFUD_11525	ENOG4105C3G	gtp-binding protein
XFUD_11530	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
XFUD_11535	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
XFUD_11540	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
XFUD_11550	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
XFUD_11555	ENOG4108D76	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
XFUD_11560	ENOG4105DJQ	tetratricopeptide tpr_2 repeat protein
XFUD_11565	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
XFUD_11570	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
XFUD_11575	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
XFUD_11615	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
XFUD_11620	ENOG4105M2J	Glutaredoxin
XFUD_11625	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
XFUD_11630	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
XFUD_11635	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
XFUD_11645	ENOG4107STQ	Multicopper oxidase
XFUD_11655	ENOG4105C4R	Atp-dependent dna helicase
XFUD_11660	ENOG4105DJ9	glucan biosynthesis protein
XFUD_11665	ENOG4105D07	Signal peptide peptidase, SppA
XFUD_11670	ENOG4107QI1	Mate efflux family protein
XFUD_11690	ENOG4105C25	Primosomal protein n'
XFUD_11700	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
XFUD_11705	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
XFUD_11710	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
XFUD_11715	ENOG4105CAK	Cell division ATP-binding protein ftsE
XFUD_11720	ENOG4105C1J	atp-dependent rna helicase
XFUD_11725	ENOG4105K63	Thioredoxin
XFUD_11730	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
XFUD_11735	ENOG4105E9K	Isocitrate dehydrogenase
XFUD_11745	ENOG4105CN1	protease
XFUD_11750	ENOG41063SB	peptidase
XFUD_11765	ENOG4105BZ8	glutamate synthase
XFUD_11770	ENOG4105CBC	glutamate synthase
XFUD_11775	ENOG4105II7	pyrroline-5-carboxylate reductase
XFUD_11795	ENOG4105UBK	short-chain dehydrogenase reductase
XFUD_11820	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFUD_11860	ENOG410829K	Lysine exporter protein (Lyse ygga)
XFUD_11875	ENOG4105E7D	Protein of unknown function (DUF3375)
XFUD_11900	ENOG4105DZR	Type I site-specific deoxyribonuclease
XFUD_11915	ENOG4105CVR	type I restriction-modification system
XFUD_12020	ENOG4105YES	addiction module antidote protein
XFUD_12025	ENOG4105VUH	addiction module killer protein
XFUD_12125	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
XFUD_12140	ENOG4107FTS	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
XFUD_12210	ENOG4108V42	Type IV secretion system protein VirB8
XFUD_12220	ENOG4105CMA	conjugation trbi family protein
XFUD_12255	ENOG4108C33	Resolvase
XFUD_12320	ENOG4108YIQ	Alpha beta hydrolase
XFUD_12385	ENOG4105VUH	addiction module killer protein