locus-tag	class	description
XFUD_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
XFUD_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
XFUD_00025	COG0187	DNA topoisomerase II activity
XFUD_00035	COG0501	Belongs to the peptidase M48B family
XFUD_00075	COG0408	coproporphyrinogen oxidase activity
XFUD_00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
XFUD_00115	COG4969	Belongs to the N-Me-Phe pilin family
XFUD_00145	COG0284	orotidine-5'-phosphate decarboxylase activity
XFUD_00160	COG1970	mechanosensitive ion channel activity
XFUD_00175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
XFUD_00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
XFUD_00195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
XFUD_00200	COG0511	ligase activity, forming carbon-carbon bonds
XFUD_00205	COG0439	Biotin carboxylase
XFUD_00210	COG0210	DNA helicase
XFUD_00220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
XFUD_00220	COG1017	nitric oxide dioxygenase activity
XFUD_00235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
XFUD_00245	COG1040	competence protein
XFUD_00250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
XFUD_00255	COG1752	Esterase of the alpha-beta hydrolase superfamily
XFUD_00260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
XFUD_00295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFUD_00305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
XFUD_00325	COG3539	Fimbrial protein
XFUD_00340	COG3121	Chaperone
XFUD_00345	COG3539	Fimbrial protein
XFUD_00350	COG1546	Belongs to the CinA family
XFUD_00355	COG0477	Major facilitator Superfamily
XFUD_00360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
XFUD_00365	COG1923	regulation of RNA biosynthetic process
XFUD_00370	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
XFUD_00375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
XFUD_00385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
XFUD_00390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
XFUD_00395	COG1534	Rna-binding protein
XFUD_00405	COG0129	dihydroxy-acid dehydratase activity
XFUD_00430	COG1560	Kdo2-lipid A biosynthetic process
XFUD_00435	COG1519	Transferase
XFUD_00445	COG0228	four-way junction DNA binding
XFUD_00450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
XFUD_00455	COG0336	Belongs to the RNA methyltransferase TrmD family
XFUD_00460	COG0335	large ribosomal subunit rRNA binding
XFUD_00465	COG0024	Methionine aminopeptidase
XFUD_00470	COG2171	N-acyltransferase activity
XFUD_00475	COG1393	Belongs to the ArsC family
XFUD_00480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFUD_00485	COG0367	asparagine synthase
XFUD_00495	COG2070	2-Nitropropane dioxygenase
XFUD_00500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
XFUD_00505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
XFUD_00510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
XFUD_00525	COG0339	signal peptide processing
XFUD_00535	COG2132	Multicopper oxidase
XFUD_00545	COG0525	valine-tRNA ligase activity
XFUD_00565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFUD_00585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFUD_00595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
XFUD_00600	COG1166	arginine decarboxylase activity
XFUD_00605	COG4221	oxidoreductase activity
XFUD_00615	COG0018	arginyl-trna synthetase
XFUD_00620	COG2003	Belongs to the UPF0758 family
XFUD_00625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
XFUD_00630	COG0756	dUTP diphosphatase activity
XFUD_00635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFUD_00645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
XFUD_00680	COG2223	nitrite transmembrane transporter activity
XFUD_00685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
XFUD_00690	COG0739	heme binding
XFUD_00695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
XFUD_00725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
XFUD_00740	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_00745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
XFUD_00750	COG1272	protein, Hemolysin III
XFUD_00755	COG0463	Glycosyl transferase, family 2
XFUD_00760	COG0084	hydrolase, TatD family'
XFUD_00775	COG0509	glycine decarboxylation via glycine cleavage system
XFUD_00780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
XFUD_00790	COG0330	HflC and HflK could
XFUD_00795	COG3956	TIGRFAM MazG family protein
XFUD_00800	COG1218	3'(2'),5'-bisphosphate nucleotidase
XFUD_00805	COG0494	nUDIX hydrolase
XFUD_00815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
XFUD_00820	COG0513	Belongs to the DEAD box helicase family
XFUD_00825	COG0720	synthase
XFUD_00860	COG0825	malonyl-CoA metabolic process
XFUD_00865	COG0587	DNA-directed DNA polymerase activity
XFUD_00870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
XFUD_00890	COG0512	Glutamine amidotransferase of anthranilate synthase
XFUD_00895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
XFUD_00900	COG0134	indole-3-glycerol-phosphate synthase activity
XFUD_00920	COG0006	proline dipeptidase activity
XFUD_00935	COG0343	queuine tRNA-ribosyltransferase activity
XFUD_00940	COG1862	Preprotein translocase
XFUD_00945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
XFUD_00960	COG0617	tRNA 3'-terminal CCA addition
XFUD_00970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
XFUD_00975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
XFUD_00980	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
XFUD_00985	COG0166	Belongs to the GPI family
XFUD_01000	COG0779	Required for maturation of 30S ribosomal subunits
XFUD_01005	COG0195	Participates in both transcription termination and antitermination
XFUD_01010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
XFUD_01015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
XFUD_01020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
XFUD_01025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
XFUD_01030	COG1185	polyribonucleotide nucleotidyltransferase activity
XFUD_01035	COG1733	regulation of RNA biosynthetic process
XFUD_01040	COG0702	epimerase
XFUD_01090	COG2086	electron transfer activity
XFUD_01120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFUD_01150	COG0477	Major facilitator Superfamily
XFUD_01165	COG0563	adenylate kinase activity
XFUD_01170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFUD_01175	COG0671	phosphoesterase, PA-phosphatase related
XFUD_01185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
XFUD_01190	COG0628	permease
XFUD_01210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFUD_01215	COG1090	epimerase
XFUD_01220	COG0318	PFAM AMP-dependent synthetase and ligase
XFUD_01240	COG1049	propionate catabolic process, 2-methylcitrate cycle
XFUD_01265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFUD_01305	COG0149	triose-phosphate isomerase activity
XFUD_01320	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_01325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_01330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_01335	COG0649	NAD binding
XFUD_01340	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
XFUD_01345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
XFUD_01350	COG1034	ATP synthesis coupled electron transport
XFUD_01355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
XFUD_01360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
XFUD_01370	COG0713	ATP synthesis coupled electron transport
XFUD_01385	COG1007	ATP synthesis coupled electron transport
XFUD_01390	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_01395	COG2851	Citrate transporter
XFUD_01410	COG0642	Histidine kinase
XFUD_01425	COG0675	Transposase, IS605 OrfB family
XFUD_01460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
XFUD_01465	COG4206	TonB-dependent receptor
XFUD_01470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
XFUD_01490	COG0277	FAD linked oxidase domain protein
XFUD_01495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFUD_01505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
XFUD_01510	COG2124	cytochrome p450
XFUD_01525	COG0305	Participates in initiation and elongation during chromosome replication
XFUD_01540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFUD_01545	COG0667	Aldo Keto reductase
XFUD_01550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
XFUD_01585	COG2194	sulfuric ester hydrolase activity
XFUD_01590	COG2124	cytochrome p450
XFUD_01595	COG0352	thiamine-phosphate diphosphorylase activity
XFUD_01605	COG0542	response to heat
XFUD_01625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
XFUD_01635	COG0745	RESPONSE REGULATOR receiver
XFUD_01640	COG2205	protein histidine kinase activity
XFUD_01645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
XFUD_01660	COG0494	nUDIX hydrolase
XFUD_01670	COG2193	ferroxidase activity
XFUD_01700	COG0861	Integral membrane protein TerC family
XFUD_01705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFUD_01710	COG0531	amino acid
XFUD_01720	COG1116	anion transmembrane transporter activity
XFUD_01725	COG1322	Protein conserved in bacteria
XFUD_01735	COG2853	Lipoprotein
XFUD_01750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFUD_01755	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFUD_01760	COG1127	ABC transporter
XFUD_01770	COG1074	ATP-dependent DNA helicase activity
XFUD_01785	COG0180	Tryptophanyl-tRNA synthetase
XFUD_01790	COG0358	DNA primase activity
XFUD_01800	COG1610	YqeY-like protein
XFUD_01805	COG0828	Belongs to the bacterial ribosomal protein bS21 family
XFUD_01810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
XFUD_01815	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
XFUD_01820	COG0668	transmembrane transport
XFUD_01840	COG1183	phosphatidylcholine synthase activity
XFUD_01850	COG0442	prolyl-tRNA aminoacylation
XFUD_01875	COG0604	alcohol dehydrogenase
XFUD_01880	COG0330	HflC and HflK could
XFUD_01885	COG0330	HflC and HflK could
XFUD_01895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
XFUD_01900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
XFUD_01905	COG0105	UTP biosynthetic process
XFUD_01910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
XFUD_01930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_01935	COG1160	GTP binding
XFUD_01940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
XFUD_01945	COG4943	cyclic-guanylate-specific phosphodiesterase activity
XFUD_01955	COG4968	Prepilin-type N-terminal cleavage methylation domain
XFUD_02000	COG0629	single-stranded DNA binding
XFUD_02020	COG4969	Belongs to the N-Me-Phe pilin family
XFUD_02070	COG2856	Zn peptidase
XFUD_02090	COG4197	protein conserved in bacteria, prophage-related
XFUD_02145	COG0740	serine-type endopeptidase activity
XFUD_02160	COG3772	lysozyme
XFUD_02205	COG5449	Phage conserved hypothetical protein BR0599
XFUD_02270	COG0675	Transposase, IS605 OrfB family
XFUD_02310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFUD_02310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFUD_02320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
XFUD_02325	COG3107	peptidoglycan biosynthetic process
XFUD_02330	COG0792	nuclease activity
XFUD_02335	COG1162	GTPase activity
XFUD_02340	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
XFUD_02350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFUD_02350	COG0519	Catalyzes the synthesis of GMP from XMP
XFUD_02365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFUD_02370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
XFUD_02380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
XFUD_02390	COG2974	May be involved in recombination
XFUD_02395	COG0037	tRNA processing
XFUD_02405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFUD_02420	COG3590	peptidase
XFUD_02440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
XFUD_02445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
XFUD_02455	COG0628	permease
XFUD_02465	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
XFUD_02470	COG3178	'Phosphotransferase
XFUD_02475	COG1555	photosystem II stabilization
XFUD_02480	COG1477	protein flavinylation
XFUD_02500	COG3128	pkhd-type hydroxylase
XFUD_02505	COG4774	siderophore transport
XFUD_02525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
XFUD_02540	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
XFUD_02550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFUD_02575	COG0459	protein refolding
XFUD_02585	COG1324	tolerance protein
XFUD_02595	COG0352	thiamine-phosphate diphosphorylase activity
XFUD_02595	COG0351	phosphomethylpyrimidine kinase
XFUD_02600	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
XFUD_02700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
XFUD_02710	COG2311	Membrane
XFUD_02720	COG0791	NLP P60 protein
XFUD_02725	COG0791	NLP P60 protein
XFUD_02735	COG1301	dicarboxylic acid transport
XFUD_02745	COG0037	tRNA processing
XFUD_02750	COG1722	exodeoxyribonuclease VII activity
XFUD_02755	COG0142	geranyltranstransferase activity
XFUD_02795	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_02810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
XFUD_02815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
XFUD_02975	COG3772	lysozyme
XFUD_03045	COG3093	addiction module antidote protein HigA
XFUD_03120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
XFUD_03125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
XFUD_03135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
XFUD_03140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
XFUD_03145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
XFUD_03145	COG0072	phenylalanine-tRNA ligase activity
XFUD_03150	COG0776	regulation of translation
XFUD_03165	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
XFUD_03190	COG1570	exodeoxyribonuclease VII activity
XFUD_03200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
XFUD_03200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
XFUD_03205	COG0802	atpase or kinase
XFUD_03215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
XFUD_03225	COG0717	Belongs to the dCTP deaminase family
XFUD_03230	COG0730	response to heat
XFUD_03235	COG2391	methyltransferase activity
XFUD_03240	COG2391	methyltransferase activity
XFUD_03245	COG0640	Transcriptional regulator
XFUD_03250	COG3453	Protein conserved in bacteria
XFUD_03250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFUD_03275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFUD_03305	COG2755	lipolytic protein G-D-S-L family
XFUD_03305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
XFUD_03335	COG2022	thiamine diphosphate biosynthetic process
XFUD_03340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
XFUD_03355	COG2001	Belongs to the MraZ family
XFUD_03360	COG0275	rRNA processing
XFUD_03365	COG3116	cell division
XFUD_03375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
XFUD_03380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
XFUD_03385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
XFUD_03395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
XFUD_03400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
XFUD_03405	COG1181	Belongs to the D-alanine--D-alanine ligase family
XFUD_03410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
XFUD_03420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
XFUD_03425	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
XFUD_03435	COG0739	heme binding
XFUD_03440	COG0653	protein targeting
XFUD_03445	COG4305	rare lipoprotein A
XFUD_03460	COG0612	Peptidase, M16
XFUD_03465	COG5297	Belongs to the glycosyl hydrolase family 6
XFUD_03465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFUD_03475	COG0735	belongs to the Fur family
XFUD_03480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFUD_03485	COG0126	phosphoglycerate kinase activity
XFUD_03490	COG0469	pyruvate kinase activity
XFUD_03495	COG3588	fructose-bisphosphate aldolase
XFUD_03525	COG0583	DNA-binding transcription factor activity
XFUD_03530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFUD_03535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
XFUD_03540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
XFUD_03545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
XFUD_03550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
XFUD_03560	COG3537	Alpha-1,2-mannosidase
XFUD_03575	COG1472	Belongs to the glycosyl hydrolase 3 family
XFUD_03585	COG3525	Glycosyl hydrolase, family 20, catalytic domain
XFUD_03590	COG1388	LysM domain
XFUD_03590	COG3858	chitin binding
XFUD_03595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFUD_03600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
XFUD_03605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
XFUD_03610	COG5002	protein histidine kinase activity
XFUD_03625	COG1238	metal cluster binding
XFUD_03630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFUD_03635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
XFUD_03640	COG0739	heme binding
XFUD_03645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFUD_03650	COG0626	cystathionine gamma-synthase activity
XFUD_03670	COG0508	dehydrogenase complex catalyzes the overall conversion of
XFUD_03680	COG1464	Belongs to the NlpA lipoprotein family
XFUD_03685	COG2011	ABC-type metal ion transport system permease component
XFUD_03690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
XFUD_03705	COG0288	reversible hydration of carbon dioxide
XFUD_03715	COG1199	ATP-dependent helicase activity
XFUD_03725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFUD_03860	COG4535	Mg2 and Co2 transporter CorC
XFUD_03870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
XFUD_03875	COG1702	phosphate starvation-inducible protein PhoH
XFUD_03880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
XFUD_03885	COG0741	lytic transglycosylase activity
XFUD_03890	COG0723	plastoquinol--plastocyanin reductase activity
XFUD_03895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
XFUD_03900	COG2857	Cytochrome c1
XFUD_03910	COG2969	positive regulation of protein catabolic process
XFUD_03945	COG0009	L-threonylcarbamoyladenylate synthase
XFUD_03950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFUD_03950	COG1754	DNA topoisomerase type I activity
XFUD_03960	COG2922	Belongs to the Smg family
XFUD_03965	COG0758	DNA mediated transformation
XFUD_03980	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
XFUD_03985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFUD_03985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
XFUD_03990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
XFUD_04005	COG1918	ferrous iron import across plasma membrane
XFUD_04005	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
XFUD_04025	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_04030	COG0564	pseudouridine synthase activity
XFUD_04040	COG3011	Protein conserved in bacteria
XFUD_04045	COG0579	oxidoreductase
XFUD_04050	COG0488	(ABC) transporter
XFUD_04055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
XFUD_04065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
XFUD_04070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFUD_04070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
XFUD_04085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
XFUD_04090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
XFUD_04095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
XFUD_04115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
XFUD_04125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
XFUD_04140	COG0556	nucleotide-excision repair
XFUD_04180	COG1301	dicarboxylic acid transport
XFUD_04185	COG0280	phosphate acetyltransferase
XFUD_04185	COG0281	malic enzyme
XFUD_04190	COG0326	Molecular chaperone. Has ATPase activity
XFUD_04195	COG0742	ribosomal rna small subunit methyltransferase
XFUD_04200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
XFUD_04210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
XFUD_04220	COG3706	GGDEF domain
XFUD_04230	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
XFUD_04235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
XFUD_04240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
XFUD_04255	COG2166	iron-sulfur cluster assembly
XFUD_04260	COG0215	cysteine-tRNA ligase activity
XFUD_04270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
XFUD_04275	COG0137	argininosuccinate synthase activity
XFUD_04280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
XFUD_04285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
XFUD_04295	COG0165	Argininosuccinate lyase
XFUD_04300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
XFUD_04305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
XFUD_04340	COG0590	tRNA wobble adenosine to inosine editing
XFUD_04345	COG1321	iron dependent repressor
XFUD_04350	COG1914	H( )-stimulated, divalent metal cation uptake system
XFUD_04355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
XFUD_04365	COG1946	Acyl-CoA thioesterase
XFUD_04390	COG2937	Belongs to the GPAT DAPAT family
XFUD_04405	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
XFUD_04415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
XFUD_04420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_04425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_04430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
XFUD_04435	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_04445	COG0750	zinc metalloprotease
XFUD_04450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
XFUD_04455	COG0575	Belongs to the CDS family
XFUD_04460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
XFUD_04465	COG0233	cytoplasmic translational termination
XFUD_04470	COG2067	long-chain fatty acid transport protein
XFUD_04485	COG0528	UMP kinase activity
XFUD_04520	COG0363	glucosamine-6-phosphate deaminase activity
XFUD_04525	COG0837	glucose binding
XFUD_04530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
XFUD_04535	COG3842	ATPase activity
XFUD_04540	COG0354	folic acid binding
XFUD_04550	COG2009	succinate dehydrogenase
XFUD_04555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
XFUD_04565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
XFUD_04570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
XFUD_04580	COG4591	ABC-type transport system involved in lipoprotein release permease component
XFUD_04585	COG1136	(ABC) transporter
XFUD_04595	COG0811	peptide transport
XFUD_04605	COG1132	(ABC) transporter
XFUD_04610	COG1663	tetraacyldisaccharide 4'-kinase activity
XFUD_04630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFUD_04645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
XFUD_04670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
XFUD_04675	COG0505	Belongs to the CarA family
XFUD_04680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
XFUD_04685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
XFUD_04695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
XFUD_04700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
XFUD_04705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
XFUD_04720	COG1024	Enoyl-CoA hydratase
XFUD_04725	COG0019	diaminopimelate decarboxylase activity
XFUD_04735	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
XFUD_04745	COG0494	nUDIX hydrolase
XFUD_04760	COG0424	maF-like protein
XFUD_04765	COG1530	ribonuclease E activity
XFUD_04775	COG0312	modulator of DNA gyrase
XFUD_04780	COG3028	Belongs to the UPF0307 family
XFUD_04785	COG0312	modulator of DNA gyrase
XFUD_04790	COG0583	DNA-binding transcription factor activity
XFUD_04795	COG0655	NAD(P)H dehydrogenase (quinone) activity
XFUD_04805	COG1064	alcohol dehydrogenase
XFUD_04820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
XFUD_04830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
XFUD_04835	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
XFUD_04840	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
XFUD_04845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
XFUD_04850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
XFUD_04855	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
XFUD_04865	COG0356	it plays a direct role in the translocation of protons across the membrane
XFUD_04875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
XFUD_04880	COG0088	Forms part of the polypeptide exit tunnel
XFUD_04885	COG0089	rRNA binding
XFUD_04890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
XFUD_04895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
XFUD_04900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
XFUD_04905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
XFUD_04915	COG0255	Belongs to the universal ribosomal protein uL29 family
XFUD_04920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
XFUD_04925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
XFUD_04930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
XFUD_04935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
XFUD_04940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
XFUD_04945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
XFUD_04950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
XFUD_04955	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
XFUD_04960	COG0200	Binds to the 23S rRNA
XFUD_04965	COG0201	protein transport
XFUD_04970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
XFUD_04975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
XFUD_04980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
XFUD_04990	COG0203	ribosomal protein L17
XFUD_04995	COG2960	long-chain fatty acid transporting porin activity
XFUD_05000	COG0606	chelatase, subunit chli
XFUD_05010	COG5380	lipid catabolic process
XFUD_05020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
XFUD_05035	COG0544	peptidyl-prolyl cis-trans isomerase activity
XFUD_05040	COG0740	serine-type endopeptidase activity
XFUD_05045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
XFUD_05055	COG0776	regulation of translation
XFUD_05085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFUD_05090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
XFUD_05105	COG1187	pseudouridine synthase activity
XFUD_05135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFUD_05140	COG0625	glutathione transferase activity
XFUD_05145	COG0039	L-malate dehydrogenase activity
XFUD_05150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
XFUD_05185	COG1131	(ABC) transporter
XFUD_05205	COG1643	Atp-dependent helicase
XFUD_05210	COG1956	GAF domain-containing protein
XFUD_05215	COG0729	surface antigen
XFUD_05220	COG2911	Protein conserved in bacteria
XFUD_05295	COG2373	Large extracellular alpha-helical protein
XFUD_05320	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
XFUD_05335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
XFUD_05360	COG5297	Belongs to the glycosyl hydrolase family 6
XFUD_05365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
XFUD_05370	COG0321	lipoyl(octanoyl) transferase activity
XFUD_05375	COG2921	Belongs to the UPF0250 family
XFUD_05395	COG2733	membrane
XFUD_05400	COG1253	flavin adenine dinucleotide binding
XFUD_05430	COG0504	CTP synthase activity
XFUD_05435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
XFUD_05440	COG0148	phosphopyruvate hydratase activity
XFUD_05445	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
XFUD_05450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
XFUD_05455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
XFUD_05460	COG2840	Smr protein MutS2
XFUD_05470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
XFUD_05470	COG0644	oxidoreductase
XFUD_05485	COG3218	ABC-type transport auxiliary lipoprotein component
XFUD_05485	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
XFUD_05490	COG1127	ABC transporter
XFUD_05495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
XFUD_05515	COG1077	Cell shape determining protein MreB Mrl
XFUD_05525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
XFUD_05530	COG0768	penicillin binding
XFUD_05535	COG0772	Belongs to the SEDS family
XFUD_05540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
XFUD_05545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
XFUD_05565	COG2894	cell division
XFUD_05570	COG0850	regulation of cytokinetic process
XFUD_05590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
XFUD_05600	COG3038	cytochrome b561
XFUD_05605	COG2353	YceI-like domain
XFUD_05615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
XFUD_05625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
XFUD_05635	COG0259	pyridoxamine-phosphate oxidase activity
XFUD_05640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
XFUD_05665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
XFUD_05670	COG4208	sulfate ABC transporter
XFUD_05675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
XFUD_05685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
XFUD_05695	COG1846	Transcriptional regulator
XFUD_05705	COG2267	carboxylic ester hydrolase activity
XFUD_05710	COG0156	8-amino-7-oxononanoate synthase activity
XFUD_05720	COG0109	protoheme IX farnesyltransferase activity
XFUD_05725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFUD_05730	COG0617	tRNA 3'-terminal CCA addition
XFUD_05735	COG0741	lytic transglycosylase activity
XFUD_05745	COG0688	phosphatidylethanolamine metabolic process
XFUD_05755	COG2890	protein-(glutamine-N5) methyltransferase activity
XFUD_05760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
XFUD_05765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
XFUD_05775	COG0101	tRNA pseudouridine synthase activity
XFUD_05780	COG0135	phosphoribosylanthranilate isomerase activity
XFUD_05785	COG0133	tryptophan synthase activity
XFUD_05790	COG0159	tryptophan synthase activity
XFUD_05800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
XFUD_05805	COG0514	ATP-dependent DNA helicase (RecQ)
XFUD_05810	COG0783	Belongs to the Dps family
XFUD_05815	COG1643	Atp-dependent helicase
XFUD_05830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFUD_05830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
XFUD_05835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
XFUD_05840	COG1845	cytochrome c oxidase, subunit III
XFUD_05845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
XFUD_05850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
XFUD_05855	COG0142	geranyltranstransferase activity
XFUD_05860	COG0629	single-stranded DNA binding
XFUD_05865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFUD_05885	COG2239	Acts as a magnesium transporter
XFUD_05890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
XFUD_05895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
XFUD_05905	COG1660	Displays ATPase and GTPase activities
XFUD_05925	COG1137	ATPase activity
XFUD_05940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
XFUD_05950	COG0271	Belongs to the BolA IbaG family
XFUD_05955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
XFUD_05990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
XFUD_05990	COG0047	phosphoribosylformylglycinamidine synthase activity
XFUD_05995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFUD_06000	COG4974	Belongs to the 'phage' integrase family
XFUD_06005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
XFUD_06010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
XFUD_06020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
XFUD_06045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
XFUD_06055	COG2915	High frequency lysogenization protein hflD homolog
XFUD_06070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
XFUD_06075	COG0542	response to heat
XFUD_06080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
XFUD_06085	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
XFUD_06095	COG0492	ferredoxin-NADP+ reductase activity
XFUD_06100	COG1674	ftsk spoiiie
XFUD_06110	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
XFUD_06115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
XFUD_06120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
XFUD_06125	COG4191	Histidine kinase
XFUD_06130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
XFUD_06135	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_06150	COG0837	glucose binding
XFUD_06165	COG1609	Transcriptional regulator
XFUD_06170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
XFUD_06175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
XFUD_06185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
XFUD_06190	COG0726	polysaccharide deacetylase
XFUD_06195	COG0297	glycogen (starch) synthase activity
XFUD_06205	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
XFUD_06210	COG0719	Fe-S assembly protein
XFUD_06215	COG0396	ATPase activity
XFUD_06220	COG0719	Fe-S assembly protein
XFUD_06225	COG1959	2 iron, 2 sulfur cluster binding
XFUD_06240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
XFUD_06260	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
XFUD_06270	COG2226	methyltransferase
XFUD_06275	COG0308	aminopeptidase N
XFUD_06300	COG2912	Transglutaminase-like superfamily
XFUD_06315	COG0175	sulfate reduction
XFUD_06320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
XFUD_06330	COG0175	sulfate reduction
XFUD_06335	COG2895	sulfate adenylyltransferase (ATP) activity
XFUD_06335	COG0529	Catalyzes the synthesis of activated sulfate
XFUD_06340	COG1758	RNA polymerase activity
XFUD_06345	COG0194	GDP metabolic process
XFUD_06350	COG1561	YicC-like family, N-terminal region
XFUD_06355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
XFUD_06360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
XFUD_06365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
XFUD_06380	COG0596	Alpha beta hydrolase
XFUD_06385	COG2890	protein-(glutamine-N5) methyltransferase activity
XFUD_06405	COG5295	Hep Hag repeat protein
XFUD_06410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
XFUD_06415	COG1459	type II secretion system
XFUD_06420	COG2165	general secretion pathway protein
XFUD_06425	COG4970	Tfp pilus assembly protein FimT
XFUD_06430	COG2165	general secretion pathway protein
XFUD_06435	COG4795	General secretion pathway protein
XFUD_06440	COG3156	type II secretion system protein K
XFUD_06445	COG3166	PFAM Fimbrial assembly family protein
XFUD_06460	COG1450	Type ii and iii secretion system protein
XFUD_06470	COG0450	alkyl hydroperoxide reductase
XFUD_06475	COG3634	alkyl hydroperoxide reductase activity
XFUD_06480	COG0583	DNA-binding transcription factor activity
XFUD_06490	COG0254	rRNA binding
XFUD_06500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
XFUD_06505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
XFUD_06510	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
XFUD_06515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
XFUD_06530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
XFUD_06555	COG0567	Dehydrogenase, E1 component
XFUD_06560	COG2850	peptidyl-arginine hydroxylation
XFUD_06575	COG0114	fumarate hydratase activity
XFUD_06585	COG0629	single-stranded DNA binding
XFUD_06605	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFUD_06625	COG3772	lysozyme
XFUD_06650	COG5410	chromosome segregation
XFUD_06675	COG2369	cell adhesion
XFUD_06745	COG1487	ribonuclease activity
XFUD_06750	COG4691	Plasmid stability protein
XFUD_06780	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFUD_06785	COG3657	addiction module killer protein
XFUD_06805	COG1131	(ABC) transporter
XFUD_06810	COG0386	Belongs to the glutathione peroxidase family
XFUD_06825	COG2900	Belongs to the SlyX family
XFUD_06840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
XFUD_06850	COG2027	D-alanyl-D-alanine carboxypeptidase
XFUD_06865	COG2226	methyltransferase
XFUD_06880	COG2943	transferase activity, transferring hexosyl groups
XFUD_06890	COG3275	phosphorelay sensor kinase activity
XFUD_06900	COG0181	hydroxymethylbilane synthase activity
XFUD_06935	COG0463	Glycosyl transferase, family 2
XFUD_06945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
XFUD_06960	COG0392	lysyltransferase activity
XFUD_06960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
XFUD_06965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
XFUD_06970	COG0629	single-stranded DNA binding
XFUD_06995	COG5532	Uncharacterized conserved protein (DUF2303)
XFUD_07100	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
XFUD_07115	COG3772	lysozyme
XFUD_07140	COG5410	chromosome segregation
XFUD_07170	COG2369	cell adhesion
XFUD_07275	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFUD_07280	COG3657	addiction module killer protein
XFUD_07320	COG0251	oxidation-reduction process
XFUD_07340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
XFUD_07345	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
XFUD_07350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
XFUD_07360	COG0582	viral genome integration into host DNA
XFUD_07370	COG1396	sequence-specific DNA binding
XFUD_07380	COG0667	Aldo Keto reductase
XFUD_07385	COG0667	Aldo Keto reductase
XFUD_07390	COG1942	4-Oxalocrotonate Tautomerase
XFUD_07410	COG0667	Aldo Keto reductase
XFUD_07415	COG0583	DNA-binding transcription factor activity
XFUD_07420	COG1902	pentaerythritol trinitrate reductase activity
XFUD_07430	COG1064	alcohol dehydrogenase
XFUD_07460	COG2133	pyrroloquinoline quinone binding
XFUD_07465	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_07470	COG3386	PFAM SMP-30 Gluconolaconase
XFUD_07480	COG4221	oxidoreductase activity
XFUD_07490	COG1064	alcohol dehydrogenase
XFUD_07655	COG0270	DNA (cytosine-5-)-methyltransferase activity
XFUD_07665	COG0629	single-stranded DNA binding
XFUD_07705	COG1192	Involved in chromosome partitioning
XFUD_07750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
XFUD_07755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
XFUD_07755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
XFUD_07780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
XFUD_07785	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
XFUD_07790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
XFUD_07820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
XFUD_07825	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
XFUD_07830	COG0537	adenosine 5'-monophosphoramidase activity
XFUD_07850	COG0714	Associated with various cellular activities
XFUD_07860	COG1399	metal-binding, possibly nucleic acid-binding protein
XFUD_07865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
XFUD_07870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFUD_07875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
XFUD_07895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
XFUD_07905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
XFUD_07910	COG1764	response to oxidative stress
XFUD_07915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
XFUD_07940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
XFUD_07950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
XFUD_07975	COG1968	undecaprenyl-diphosphatase activity
XFUD_07980	COG0174	glutamine synthetase
XFUD_07985	COG0347	Belongs to the P(II) protein family
XFUD_07990	COG0004	ammonium transporteR
XFUD_07995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFUD_08000	COG2204	response regulator
XFUD_08005	COG3852	Histidine kinase
XFUD_08035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
XFUD_08040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
XFUD_08060	COG2337	Toxic component of a toxin-antitoxin (TA) module
XFUD_08155	COG0406	alpha-ribazole phosphatase activity
XFUD_08175	COG0386	Belongs to the glutathione peroxidase family
XFUD_08180	COG3104	oligopeptide transport
XFUD_08185	COG1515	deoxyribonuclease V activity
XFUD_08190	COG0588	phosphoglycerate mutase activity
XFUD_08195	COG0602	queuosine metabolic process
XFUD_08205	COG2885	chlorophyll binding
XFUD_08210	COG0823	Involved in the tonB-independent uptake of proteins
XFUD_08230	COG0824	Thioesterase
XFUD_08235	COG2255	four-way junction helicase activity
XFUD_08240	COG3158	transport of potassium into the cell
XFUD_08245	COG0632	four-way junction helicase activity
XFUD_08250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
XFUD_08255	COG0217	transcriptional regulatory protein
XFUD_08260	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
XFUD_08270	COG0552	protein localization to endoplasmic reticulum
XFUD_08285	COG0084	hydrolase, TatD family'
XFUD_08320	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
XFUD_08325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
XFUD_08335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
XFUD_08340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
XFUD_08385	COG2091	lysine biosynthetic process via aminoadipic acid
XFUD_08390	COG0357	Ribosomal RNA small subunit methyltransferase G
XFUD_08395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
XFUD_08400	COG1301	dicarboxylic acid transport
XFUD_08405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
XFUD_08425	COG0339	signal peptide processing
XFUD_08435	COG0285	dihydrofolate synthase activity
XFUD_08470	COG0840	transmembrane signaling receptor activity
XFUD_08485	COG0189	ligase activity
XFUD_08500	COG0751	glycine-tRNA ligase activity
XFUD_08505	COG0752	glycyl-tRNA synthetase alpha subunit
XFUD_08510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
XFUD_08510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
XFUD_08525	COG0596	Alpha beta hydrolase
XFUD_08540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
XFUD_08550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
XFUD_08560	COG0138	bifunctional purine biosynthesis protein purh
XFUD_08565	COG0151	Belongs to the GarS family
XFUD_08575	COG1289	transmembrane transporter activity
XFUD_08580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
XFUD_08595	COG0302	gtp cyclohydrolase
XFUD_08600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFUD_08605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
XFUD_08625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFUD_08630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
XFUD_08660	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
XFUD_08665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
XFUD_08705	COG0006	proline dipeptidase activity
XFUD_08710	COG3079	Belongs to the UPF0149 family
XFUD_08725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
XFUD_08735	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
XFUD_08745	COG0025	NhaP-type Na H and K H
XFUD_08760	COG2925	Exonuclease
XFUD_08785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFUD_09005	COG3609	addiction module antidote protein, CC2985 family
XFUD_09045	COG3077	Addiction module antitoxin, RelB DinJ family
XFUD_09050	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_09055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFUD_09085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
XFUD_09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFUD_09105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFUD_09110	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
XFUD_09115	COG1469	GTP cyclohydrolase I activity
XFUD_09135	COG0445	tRNA wobble uridine modification
XFUD_09260	COG0488	(ABC) transporter
XFUD_09270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
XFUD_09285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
XFUD_09285	COG4651	solute:proton antiporter activity
XFUD_09290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
XFUD_09295	COG0573	inorganic phosphate transmembrane transporter activity
XFUD_09300	COG0581	inorganic phosphate transmembrane transporter activity
XFUD_09305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
XFUD_09310	COG0704	Plays a role in the regulation of phosphate uptake
XFUD_09315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFUD_09320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
XFUD_09325	COG2967	ApaG domain
XFUD_09330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
XFUD_09340	COG3642	lipopolysaccharide core region biosynthetic process
XFUD_09345	COG0859	PFAM glycosyl transferase family 9
XFUD_09360	COG0631	protein serine/threonine phosphatase activity
XFUD_09365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
XFUD_09370	COG0328	RNA-DNA hybrid ribonuclease activity
XFUD_09380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
XFUD_09385	COG2183	response to ionizing radiation
XFUD_09400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
XFUD_09405	COG3118	belongs to the thioredoxin family
XFUD_09415	COG0495	leucyl-tRNA aminoacylation
XFUD_09430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
XFUD_09455	COG2951	lytic endotransglycosylase activity
XFUD_09590	COG2264	protein methyltransferase activity
XFUD_09600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
XFUD_09605	COG0277	FAD linked oxidase domain protein
XFUD_09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
XFUD_09615	COG0531	amino acid
XFUD_09620	COG0531	amino acid
XFUD_09625	COG0235	Class ii aldolase
XFUD_09630	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
XFUD_09635	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
XFUD_09640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
XFUD_09640	COG0140	phosphoribosyl-ATP diphosphatase activity
XFUD_09645	COG0107	imidazoleglycerol-phosphate synthase activity
XFUD_09650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
XFUD_09655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
XFUD_09660	COG0131	Imidazoleglycerol-phosphate dehydratase
XFUD_09660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
XFUD_09665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
XFUD_09670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
XFUD_09675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
XFUD_09685	COG0124	histidyl-tRNA synthetase
XFUD_09695	COG0083	homoserine kinase activity
XFUD_09700	COG0527	aspartate kinase activity
XFUD_09700	COG0460	homoserine dehydrogenase
XFUD_09705	COG0540	Belongs to the ATCase OTCase family
XFUD_09715	COG1678	Uncharacterized ACR, COG1678
XFUD_09720	COG1686	Belongs to the peptidase S11 family
XFUD_09730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
XFUD_09745	COG4953	penicillin-binding protein 1C
XFUD_09770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
XFUD_09775	COG0481	GTPase activity
XFUD_09790	COG0571	ribonuclease III activity
XFUD_09795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
XFUD_09800	COG1381	Involved in DNA repair and RecF pathway recombination
XFUD_09805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
XFUD_09820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
XFUD_09825	COG1971	Probably functions as a manganese efflux pump
XFUD_09840	COG0823	Involved in the tonB-independent uptake of proteins
XFUD_09840	COG1506	peptidase
XFUD_09845	COG1297	OPT oligopeptide transporter protein
XFUD_09865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
XFUD_09875	COG0676	glucose-6-phosphate 1-epimerase activity
XFUD_09880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
XFUD_09885	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
XFUD_09895	COG0318	PFAM AMP-dependent synthetase and ligase
XFUD_09905	COG0463	Glycosyl transferase, family 2
XFUD_09915	COG1475	DNA binding
XFUD_09920	COG1192	Involved in chromosome partitioning
XFUD_09930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
XFUD_09985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
XFUD_09990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
XFUD_09995	COG0489	protein tyrosine kinase activity
XFUD_10000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
XFUD_10040	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
XFUD_10045	COG0322	excinuclease ABC activity
XFUD_10060	COG3772	lysozyme
XFUD_10095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
XFUD_10100	COG0077	Prephenate dehydratase
XFUD_10100	COG1605	Chorismate mutase
XFUD_10105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
XFUD_10115	COG1668	transmembrane transport
XFUD_10120	COG4555	ABC transporter
XFUD_10135	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
XFUD_10140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
XFUD_10145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
XFUD_10155	COG1605	Chorismate mutase
XFUD_10155	COG0287	Prephenate dehydrogenase
XFUD_10165	COG0443	Heat shock 70 kDa protein
XFUD_10170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
XFUD_10175	COG1420	regulation of RNA biosynthetic process
XFUD_10180	COG0497	DNA recombination
XFUD_10190	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
XFUD_10195	COG2914	Belongs to the UPF0125 (RnfH) family
XFUD_10205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
XFUD_10215	COG1278	Cold shock
XFUD_10220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
XFUD_10240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
XFUD_10245	COG0745	RESPONSE REGULATOR receiver
XFUD_10250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
XFUD_10270	COG0438	transferase activity, transferring glycosyl groups
XFUD_10300	COG0473	3-isopropylmalate dehydrogenase activity
XFUD_10305	COG0066	3-isopropylmalate dehydratase activity
XFUD_10310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
XFUD_10325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFUD_10325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
XFUD_10330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
XFUD_10335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
XFUD_10350	COG1064	alcohol dehydrogenase
XFUD_10365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFUD_10435	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
XFUD_10435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
XFUD_10465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
XFUD_10475	COG0196	riboflavin kinase activity
XFUD_10480	COG0728	peptidoglycan biosynthetic process
XFUD_10485	COG0268	Binds directly to 16S ribosomal RNA
XFUD_10490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
XFUD_10495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
XFUD_10500	COG0261	This protein binds to 23S rRNA in the presence of protein L20
XFUD_10520	COG0519	Catalyzes the synthesis of GMP from XMP
XFUD_10520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
XFUD_10530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
XFUD_10535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
XFUD_10550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
XFUD_10560	COG0776	regulation of translation
XFUD_10570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
XFUD_10600	COG0395	ABC-type sugar transport system, permease component
XFUD_10605	COG1175	transmembrane transport
XFUD_10625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
XFUD_10635	COG1187	pseudouridine synthase activity
XFUD_10650	COG0436	Aminotransferase
XFUD_10655	COG4133	protoheme IX ABC transporter activity
XFUD_10670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
XFUD_10680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
XFUD_10700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
XFUD_10715	COG0546	phosphoglycolate phosphatase activity
XFUD_10720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
XFUD_10725	COG0402	S-adenosylhomocysteine deaminase activity
XFUD_10735	COG1509	lysine 2,3-aminomutase activity
XFUD_10745	COG0483	inositol monophosphate 1-phosphatase activity
XFUD_10750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
XFUD_10820	COG2944	sequence-specific DNA binding
XFUD_10890	COG3772	lysozyme
XFUD_11040	COG0582	viral genome integration into host DNA
XFUD_11055	COG0745	RESPONSE REGULATOR receiver
XFUD_11060	COG0642	Histidine kinase
XFUD_11065	COG0237	dephospho-CoA kinase activity
XFUD_11070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
XFUD_11115	COG0045	succinate-CoA ligase (ADP-forming) activity
XFUD_11120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
XFUD_11130	COG2831	hemolysin activation secretion protein
XFUD_11145	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
XFUD_11155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
XFUD_11165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
XFUD_11170	COG3115	cell septum assembly
XFUD_11180	COG0359	binds to the 23S rRNA
XFUD_11185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
XFUD_11195	COG0316	Belongs to the HesB IscA family
XFUD_11200	COG0017	Asparaginyl-tRNA synthetase
XFUD_11225	COG0167	dihydroorotate dehydrogenase activity
XFUD_11230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
XFUD_11235	COG0697	spore germination
XFUD_11240	COG0671	phosphoesterase, PA-phosphatase related
XFUD_11245	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
XFUD_11260	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
XFUD_11265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
XFUD_11280	COG1132	(ABC) transporter
XFUD_11285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
XFUD_11290	COG1538	Outer membrane efflux protein
XFUD_11295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
XFUD_11305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
XFUD_11320	COG4783	chaperone-mediated protein folding
XFUD_11330	COG0473	3-isopropylmalate dehydrogenase activity
XFUD_11340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
XFUD_11350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
XFUD_11360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
XFUD_11360	COG0316	Belongs to the HesB IscA family
XFUD_11365	COG2154	pterin-4-alpha-carbinolamine dehydratase
XFUD_11375	COG0564	pseudouridine synthase activity
XFUD_11380	COG1530	ribonuclease E activity
XFUD_11385	COG2197	response regulator
XFUD_11420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
XFUD_11425	COG1278	Cold shock
XFUD_11435	COG0501	Belongs to the peptidase M48B family
XFUD_11440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFUD_11445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
XFUD_11450	COG0049	tRNA binding
XFUD_11455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
XFUD_11460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
XFUD_11465	COG0085	RNA polymerase activity
XFUD_11470	COG0222	ribosome binding
XFUD_11475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
XFUD_11480	COG0081	regulation of translation
XFUD_11485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
XFUD_11490	COG0250	Participates in transcription elongation, termination and antitermination
XFUD_11495	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
XFUD_11505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
XFUD_11525	COG0012	GTP binding
XFUD_11530	COG0193	aminoacyl-tRNA hydrolase activity
XFUD_11535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
XFUD_11540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
XFUD_11550	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
XFUD_11555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
XFUD_11565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
XFUD_11570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
XFUD_11575	COG0116	Belongs to the methyltransferase superfamily
XFUD_11575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
XFUD_11615	COG2095	MarC family integral membrane protein
XFUD_11620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
XFUD_11635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFUD_11645	COG2132	Multicopper oxidase
XFUD_11655	COG0210	DNA helicase
XFUD_11660	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
XFUD_11665	COG0616	signal peptide processing
XFUD_11670	COG0534	Mate efflux family protein
XFUD_11690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
XFUD_11700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
XFUD_11705	COG2201	protein-glutamate methylesterase activity
XFUD_11710	COG2177	Part of the ABC transporter FtsEX involved in
XFUD_11715	COG2884	Cell division ATP-binding protein ftsE
XFUD_11720	COG0513	Belongs to the DEAD box helicase family
XFUD_11725	COG3118	belongs to the thioredoxin family
XFUD_11730	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
XFUD_11745	COG0793	Belongs to the peptidase S41A family
XFUD_11750	COG4942	peptidase
XFUD_11760	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
XFUD_11765	COG0493	'glutamate synthase
XFUD_11770	COG0069	glutamate synthase activity
XFUD_11770	COG0070	glutamate synthase
XFUD_11770	COG0067	glutamate synthase
XFUD_11795	COG1028	Short-chain dehydrogenase reductase Sdr
XFUD_11820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFUD_11860	COG1280	lysine exporter protein (LysE YggA)
XFUD_11875	COG4942	peptidase
XFUD_11900	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
XFUD_11915	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
XFUD_12020	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
XFUD_12025	COG3657	addiction module killer protein
XFUD_12125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
XFUD_12140	COG0594	ribonuclease P activity
XFUD_12165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
XFUD_12185	COG3451	type IV secretory pathway VirB4
XFUD_12210	COG3736	Type IV secretory pathway, component VirB8
XFUD_12220	COG2948	multi-organism process
XFUD_12255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
XFUD_12320	COG0596	Alpha beta hydrolase
XFUD_12385	COG3657	addiction module killer protein
XFUD_12460	COG1475	DNA binding
XFUD_12470	COG0629	single-stranded DNA binding