locus-tag	class	description
IUD23_00010	COG0592	DNA-directed DNA polymerase activity
IUD23_00020	COG0187	DNA topoisomerase II activity
IUD23_00030	COG0501	Belongs to the peptidase M48B family
IUD23_00090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IUD23_00145	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IUD23_00155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IUD23_00165	COG0511	ligase activity, forming carbon-carbon bonds
IUD23_00170	COG0439	Biotin carboxylase
IUD23_00175	COG0210	DNA helicase
IUD23_00200	COG1040	competence protein
IUD23_00210	COG1752	Esterase of the alpha-beta hydrolase superfamily
IUD23_00250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IUD23_00260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IUD23_00290	COG3121	Chaperone
IUD23_00295	COG3539	Fimbrial protein
IUD23_00300	COG1546	Belongs to the CinA family
IUD23_00305	COG0477	Major facilitator Superfamily
IUD23_00310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IUD23_00325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IUD23_00330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IUD23_00340	COG1534	Rna-binding protein
IUD23_00370	COG1560	Kdo2-lipid A biosynthetic process
IUD23_00375	COG1519	Transferase
IUD23_00415	COG1393	Belongs to the ArsC family
IUD23_00425	COG0367	asparagine synthase
IUD23_00435	COG2070	2-Nitropropane dioxygenase
IUD23_00450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IUD23_00465	COG0339	signal peptide processing
IUD23_00550	COG4221	oxidoreductase activity
IUD23_00570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IUD23_00580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD23_00635	COG2223	nitrite transmembrane transporter activity
IUD23_00645	COG0739	heme binding
IUD23_00680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IUD23_00695	COG1028	Short-chain dehydrogenase reductase Sdr
IUD23_00705	COG1272	protein, Hemolysin III
IUD23_00710	COG0463	Glycosyl transferase, family 2
IUD23_00715	COG0084	hydrolase, TatD family'
IUD23_00745	COG0330	HflC and HflK could
IUD23_00750	COG3956	TIGRFAM MazG family protein
IUD23_00755	COG1218	3'(2'),5'-bisphosphate nucleotidase
IUD23_00760	COG0494	nUDIX hydrolase
IUD23_00770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IUD23_00775	COG0513	Belongs to the DEAD box helicase family
IUD23_00780	COG0720	synthase
IUD23_00805	COG1981	membrane
IUD23_00840	COG0512	Glutamine amidotransferase of anthranilate synthase
IUD23_00875	COG0006	proline dipeptidase activity
IUD23_00895	COG1862	Preprotein translocase
IUD23_00900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUD23_00905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IUD23_00915	COG0617	tRNA 3'-terminal CCA addition
IUD23_00955	COG0195	Participates in both transcription termination and antitermination
IUD23_00985	COG1733	regulation of RNA biosynthetic process
IUD23_00990	COG0702	epimerase
IUD23_01035	COG2086	electron transfer activity
IUD23_01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD23_01095	COG0477	Major facilitator Superfamily
IUD23_01115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IUD23_01120	COG0671	phosphoesterase, PA-phosphatase related
IUD23_01135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IUD23_01140	COG0628	permease
IUD23_01160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUD23_01165	COG1090	epimerase
IUD23_01170	COG0318	PFAM AMP-dependent synthetase and ligase
IUD23_01190	COG1049	propionate catabolic process, 2-methylcitrate cycle
IUD23_01235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD23_01260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IUD23_01280	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IUD23_01285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IUD23_01290	COG1034	ATP synthesis coupled electron transport
IUD23_01325	COG1007	ATP synthesis coupled electron transport
IUD23_01330	COG1028	Short-chain dehydrogenase reductase Sdr
IUD23_01335	COG2851	Citrate transporter
IUD23_01350	COG0642	Histidine kinase
IUD23_01365	COG0784	Response regulator, receiver
IUD23_01365	COG2205	protein histidine kinase activity
IUD23_01385	COG0280	phosphate acetyltransferase
IUD23_01385	COG0281	malic enzyme
IUD23_01395	COG0742	ribosomal rna small subunit methyltransferase
IUD23_01415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IUD23_01435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IUD23_01455	COG1199	ATP-dependent helicase activity
IUD23_01465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IUD23_01555	COG0598	Magnesium transport protein CorA
IUD23_01565	COG4535	Mg2 and Co2 transporter CorC
IUD23_01580	COG1702	phosphate starvation-inducible protein PhoH
IUD23_01590	COG0741	lytic transglycosylase activity
IUD23_01595	COG0723	plastoquinol--plastocyanin reductase activity
IUD23_01600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IUD23_01605	COG2857	Cytochrome c1
IUD23_01610	COG0625	glutathione transferase activity
IUD23_01615	COG2969	positive regulation of protein catabolic process
IUD23_01660	COG0758	DNA mediated transformation
IUD23_01685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IUD23_01695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IUD23_01695	COG1918	ferrous iron import across plasma membrane
IUD23_01710	COG0564	pseudouridine synthase activity
IUD23_01725	COG3011	Protein conserved in bacteria
IUD23_01735	COG0488	(ABC) transporter
IUD23_01755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUD23_01755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IUD23_01780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IUD23_01800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IUD23_01845	COG0629	single-stranded DNA binding
IUD23_01850	COG3617	BRO family, N-terminal domain
IUD23_01865	COG5532	Uncharacterized conserved protein (DUF2303)
IUD23_01945	COG3617	BRO family, N-terminal domain
IUD23_01950	COG3617	BRO family, N-terminal domain
IUD23_01955	COG3617	BRO family, N-terminal domain
IUD23_01995	COG3772	lysozyme
IUD23_02020	COG5410	chromosome segregation
IUD23_02025	COG3567	Phage-associated protein, HI1409 family
IUD23_02030	COG0582	viral genome integration into host DNA
IUD23_02050	COG2369	cell adhesion
IUD23_02115	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD23_02120	COG3657	addiction module killer protein
IUD23_02155	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD23_02160	COG3657	addiction module killer protein
IUD23_02235	COG3617	BRO family, N-terminal domain
IUD23_02330	COG3617	BRO family, N-terminal domain
IUD23_02345	COG0305	Participates in initiation and elongation during chromosome replication
IUD23_02370	COG3772	lysozyme
IUD23_02395	COG5410	chromosome segregation
IUD23_02400	COG3567	Phage-associated protein, HI1409 family
IUD23_02405	COG0582	viral genome integration into host DNA
IUD23_02425	COG2369	cell adhesion
IUD23_02490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD23_02495	COG3657	addiction module killer protein
IUD23_02530	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IUD23_02535	COG3657	addiction module killer protein
IUD23_02565	COG4206	TonB-dependent receptor
IUD23_02580	COG0277	FAD linked oxidase domain protein
IUD23_02585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUD23_02595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IUD23_02620	COG0305	Participates in initiation and elongation during chromosome replication
IUD23_02630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IUD23_02635	COG0667	Aldo Keto reductase
IUD23_02675	COG2194	sulfuric ester hydrolase activity
IUD23_02760	COG2193	ferroxidase activity
IUD23_02790	COG0861	Integral membrane protein TerC family
IUD23_02795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IUD23_02800	COG0531	amino acid
IUD23_02810	COG1116	anion transmembrane transporter activity
IUD23_02820	COG2853	Lipoprotein
IUD23_02840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUD23_02845	COG1127	ABC transporter
IUD23_02850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IUD23_02855	COG1074	ATP-dependent DNA helicase activity
IUD23_02900	COG0358	DNA primase activity
IUD23_02910	COG1610	YqeY-like protein
IUD23_02925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IUD23_02930	COG0668	transmembrane transport
IUD23_02950	COG1183	phosphatidylcholine synthase activity
IUD23_02980	COG0604	alcohol dehydrogenase
IUD23_02985	COG0330	HflC and HflK could
IUD23_02990	COG0330	HflC and HflK could
IUD23_03005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IUD23_03035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD23_03045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IUD23_03050	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IUD23_03055	COG1611	Belongs to the LOG family
IUD23_03100	COG0827	DNA restriction-modification system
IUD23_03105	COG0827	DNA restriction-modification system
IUD23_03130	COG0629	single-stranded DNA binding
IUD23_03225	COG2878	Part of a membrane complex involved in electron transport
IUD23_03245	COG3107	peptidoglycan biosynthetic process
IUD23_03260	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IUD23_03275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IUD23_03275	COG0519	Catalyzes the synthesis of GMP from XMP
IUD23_03335	COG3590	peptidase
IUD23_03360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IUD23_03380	COG0628	permease
IUD23_03390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IUD23_03395	COG3178	'Phosphotransferase
IUD23_03400	COG1555	photosystem II stabilization
IUD23_03405	COG1477	protein flavinylation
IUD23_03430	COG4774	siderophore transport
IUD23_03450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IUD23_03465	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IUD23_03470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD23_03475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD23_03510	COG1324	tolerance protein
IUD23_03520	COG0352	thiamine-phosphate diphosphorylase activity
IUD23_03520	COG0351	phosphomethylpyrimidine kinase
IUD23_03575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IUD23_03590	COG2311	Membrane
IUD23_03600	COG0791	NLP P60 protein
IUD23_03605	COG0791	NLP P60 protein
IUD23_03615	COG1301	dicarboxylic acid transport
IUD23_03635	COG0037	tRNA processing
IUD23_03645	COG0142	geranyltranstransferase activity
IUD23_03690	COG1028	Short-chain dehydrogenase reductase Sdr
IUD23_03705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IUD23_03710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IUD23_03745	COG1509	lysine 2,3-aminomutase activity
IUD23_03755	COG0402	S-adenosylhomocysteine deaminase activity
IUD23_03810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUD23_03820	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IUD23_03845	COG0436	Aminotransferase
IUD23_03890	COG1175	transmembrane transport
IUD23_03895	COG0395	ABC-type sugar transport system, permease component
IUD23_03950	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IUD23_03965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IUD23_03995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IUD23_04015	COG0268	Binds directly to 16S ribosomal RNA
IUD23_04020	COG0728	peptidoglycan biosynthetic process
IUD23_04025	COG0196	riboflavin kinase activity
IUD23_04080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD23_04080	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IUD23_04140	COG0436	Aminotransferase
IUD23_04150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUD23_04165	COG1064	alcohol dehydrogenase
IUD23_04180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUD23_04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD23_04245	COG0438	transferase activity, transferring glycosyl groups
IUD23_04255	COG0438	transferase activity, transferring glycosyl groups
IUD23_04260	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IUD23_04275	COG2954	triphosphatase activity
IUD23_04285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IUD23_04295	COG1278	Cold shock
IUD23_04320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD23_04355	COG1605	Chorismate mutase
IUD23_04355	COG0287	Prephenate dehydrogenase
IUD23_04365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IUD23_04390	COG4555	ABC transporter
IUD23_04395	COG1668	transmembrane transport
IUD23_04405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IUD23_04410	COG1605	Chorismate mutase
IUD23_04410	COG0077	Prephenate dehydratase
IUD23_04510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IUD23_04520	COG0489	protein tyrosine kinase activity
IUD23_04565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IUD23_04630	COG1192	Involved in chromosome partitioning
IUD23_04645	COG0463	Glycosyl transferase, family 2
IUD23_04655	COG0318	PFAM AMP-dependent synthetase and ligase
IUD23_04660	COG1335	isochorismatase
IUD23_04665	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IUD23_04675	COG0676	glucose-6-phosphate 1-epimerase activity
IUD23_04705	COG1297	OPT oligopeptide transporter protein
IUD23_04710	COG0823	Involved in the tonB-independent uptake of proteins
IUD23_04710	COG1506	peptidase
IUD23_04715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IUD23_04780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IUD23_04810	COG4953	penicillin-binding protein 1C
IUD23_04840	COG1686	Belongs to the peptidase S11 family
IUD23_04855	COG0540	Belongs to the ATCase OTCase family
IUD23_04860	COG0527	aspartate kinase activity
IUD23_04860	COG0460	homoserine dehydrogenase
IUD23_04930	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IUD23_04940	COG0531	amino acid
IUD23_04945	COG0531	amino acid
IUD23_04950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IUD23_04955	COG0277	FAD linked oxidase domain protein
IUD23_05135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IUD23_05185	COG0069	glutamate synthase activity
IUD23_05185	COG0070	glutamate synthase
IUD23_05185	COG0067	glutamate synthase
IUD23_05190	COG0493	'glutamate synthase
IUD23_05195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IUD23_05210	COG4942	peptidase
IUD23_05215	COG0793	Belongs to the peptidase S41A family
IUD23_05235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IUD23_05240	COG3118	belongs to the thioredoxin family
IUD23_05250	COG2884	Cell division ATP-binding protein ftsE
IUD23_05255	COG2177	Part of the ABC transporter FtsEX involved in
IUD23_05260	COG2201	protein-glutamate methylesterase activity
IUD23_05275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IUD23_05295	COG0616	signal peptide processing
IUD23_05305	COG0210	DNA helicase
IUD23_05315	COG2132	Multicopper oxidase
IUD23_05340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IUD23_05350	COG2095	MarC family integral membrane protein
IUD23_05445	COG0012	GTP binding
IUD23_05545	COG1278	Cold shock
IUD23_05555	COG0488	(ABC) transporter
IUD23_05570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUD23_05585	COG2197	response regulator
IUD23_05590	COG1530	ribonuclease E activity
IUD23_05595	COG0564	pseudouridine synthase activity
IUD23_05620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IUD23_05625	COG3083	sulfuric ester hydrolase activity
IUD23_05630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IUD23_05640	COG0473	3-isopropylmalate dehydrogenase activity
IUD23_05650	COG4783	chaperone-mediated protein folding
IUD23_05655	COG0745	RESPONSE REGULATOR receiver
IUD23_05685	COG1538	Outer membrane efflux protein
IUD23_05690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IUD23_05695	COG1132	(ABC) transporter
IUD23_05710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IUD23_05715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IUD23_05730	COG0671	phosphoesterase, PA-phosphatase related
IUD23_05735	COG0697	spore germination
IUD23_05775	COG0316	Belongs to the HesB IscA family
IUD23_05785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IUD23_05815	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IUD23_05840	COG2831	hemolysin activation secretion protein
IUD23_05850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IUD23_05895	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IUD23_05905	COG0642	Histidine kinase
IUD23_05910	COG0745	RESPONSE REGULATOR receiver
IUD23_05935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IUD23_06010	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IUD23_06010	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IUD23_06015	COG0802	atpase or kinase
IUD23_06020	COG0860	N-Acetylmuramoyl-L-alanine amidase
IUD23_06080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IUD23_06130	COG0471	metal ion transport
IUD23_06130	COG3273	potassium ion transport
IUD23_06145	COG3116	cell division
IUD23_06160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IUD23_06190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IUD23_06200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IUD23_06215	COG0739	heme binding
IUD23_06225	COG4305	rare lipoprotein A
IUD23_06245	COG0612	Peptidase, M16
IUD23_06255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IUD23_06255	COG5297	Belongs to the glycosyl hydrolase family 6
IUD23_06265	COG0735	belongs to the Fur family
IUD23_06290	COG0469	pyruvate kinase activity
IUD23_06335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUD23_06340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IUD23_06365	COG3537	Alpha-1,2-mannosidase
IUD23_06380	COG1472	Belongs to the glycosyl hydrolase 3 family
IUD23_06390	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IUD23_06395	COG1388	LysM domain
IUD23_06395	COG3858	chitin binding
IUD23_06435	COG1238	metal cluster binding
IUD23_06455	COG0739	heme binding
IUD23_06460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IUD23_06465	COG0626	cystathionine gamma-synthase activity
IUD23_06475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IUD23_06480	COG0508	dehydrogenase complex catalyzes the overall conversion of
IUD23_06500	COG2011	ABC-type metal ion transport system permease component
IUD23_06525	COG0288	reversible hydration of carbon dioxide
IUD23_06540	COG2166	iron-sulfur cluster assembly
IUD23_06565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IUD23_06655	COG1914	H( )-stimulated, divalent metal cation uptake system
IUD23_06670	COG1946	Acyl-CoA thioesterase
IUD23_06760	COG0575	Belongs to the CDS family
IUD23_06880	COG3772	lysozyme
IUD23_06900	COG3617	BRO family, N-terminal domain
IUD23_06975	COG3617	BRO family, N-terminal domain
IUD23_07005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD23_07020	COG0528	UMP kinase activity
IUD23_07050	COG0800	Aldolase
IUD23_07080	COG0354	folic acid binding
IUD23_07090	COG2009	succinate dehydrogenase
IUD23_07095	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IUD23_07105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IUD23_07135	COG0811	peptide transport
IUD23_07180	COG3077	Addiction module antitoxin, RelB DinJ family
IUD23_07265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD23_07335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IUD23_07360	COG1024	Enoyl-CoA hydratase
IUD23_07365	COG0527	aspartate kinase activity
IUD23_07385	COG0494	nUDIX hydrolase
IUD23_07390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IUD23_07415	COG0312	modulator of DNA gyrase
IUD23_07425	COG0312	modulator of DNA gyrase
IUD23_07430	COG0583	DNA-binding transcription factor activity
IUD23_07445	COG1064	alcohol dehydrogenase
IUD23_07505	COG0356	it plays a direct role in the translocation of protons across the membrane
IUD23_07620	COG0201	protein transport
IUD23_07650	COG2960	long-chain fatty acid transporting porin activity
IUD23_07655	COG0606	chelatase, subunit chli
IUD23_07665	COG5380	lipid catabolic process
IUD23_07675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IUD23_07700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IUD23_07735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUD23_07740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IUD23_07755	COG1187	pseudouridine synthase activity
IUD23_07760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IUD23_07780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IUD23_07785	COG0625	glutathione transferase activity
IUD23_07795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IUD23_07800	COG1217	gtp-binding protein TYPA
IUD23_07840	COG0842	Transport permease protein
IUD23_07845	COG1131	(ABC) transporter
IUD23_07865	COG1643	Atp-dependent helicase
IUD23_07875	COG1956	GAF domain-containing protein
IUD23_07885	COG0729	surface antigen
IUD23_07890	COG2911	Protein conserved in bacteria
IUD23_07900	COG0582	viral genome integration into host DNA
IUD23_08065	COG0668	transmembrane transport
IUD23_08095	COG5297	Belongs to the glycosyl hydrolase family 6
IUD23_08100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IUD23_08130	COG2733	membrane
IUD23_08135	COG1253	flavin adenine dinucleotide binding
IUD23_08190	COG2840	Smr protein MutS2
IUD23_08200	COG0644	oxidoreductase
IUD23_08200	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IUD23_08215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IUD23_08215	COG3218	ABC-type transport auxiliary lipoprotein component
IUD23_08220	COG1127	ABC transporter
IUD23_08225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IUD23_08265	COG1077	Cell shape determining protein MreB Mrl
IUD23_08275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IUD23_08280	COG0768	penicillin binding
IUD23_08285	COG0772	Belongs to the SEDS family
IUD23_08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IUD23_08315	COG2894	cell division
IUD23_08335	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IUD23_08350	COG2353	YceI-like domain
IUD23_08415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IUD23_08420	COG4208	sulfate ABC transporter
IUD23_08445	COG1846	Transcriptional regulator
IUD23_08470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IUD23_08480	COG0741	lytic transglycosylase activity
IUD23_08505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IUD23_08540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IUD23_08550	COG0514	ATP-dependent DNA helicase (RecQ)
IUD23_08555	COG0783	Belongs to the Dps family
IUD23_08560	COG1643	Atp-dependent helicase
IUD23_08605	COG3617	BRO family, N-terminal domain
IUD23_08655	COG4197	protein conserved in bacteria, prophage-related
IUD23_08695	COG3772	lysozyme
IUD23_08765	COG2944	sequence-specific DNA binding
IUD23_08775	COG3093	addiction module antidote protein HigA
IUD23_08840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IUD23_08845	COG1845	cytochrome c oxidase, subunit III
IUD23_08850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IUD23_08855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IUD23_08860	COG0142	geranyltranstransferase activity
IUD23_08895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IUD23_08930	COG1137	ATPase activity
IUD23_08945	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IUD23_08990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUD23_09000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IUD23_09015	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IUD23_09035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IUD23_09065	COG0542	response to heat
IUD23_09085	COG0492	ferredoxin-NADP+ reductase activity
IUD23_09105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IUD23_09115	COG4191	Histidine kinase
IUD23_09120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IUD23_09125	COG1028	Short-chain dehydrogenase reductase Sdr
IUD23_09155	COG1609	Transcriptional regulator
IUD23_09160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IUD23_09165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IUD23_09170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IUD23_09175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IUD23_09180	COG0726	polysaccharide deacetylase
IUD23_09185	COG0297	glycogen (starch) synthase activity
IUD23_09200	COG0719	Fe-S assembly protein
IUD23_09205	COG0396	ATPase activity
IUD23_09210	COG0719	Fe-S assembly protein
IUD23_09215	COG1959	2 iron, 2 sulfur cluster binding
IUD23_09400	COG3772	lysozyme
IUD23_09420	COG3617	BRO family, N-terminal domain
IUD23_09525	COG3617	BRO family, N-terminal domain
IUD23_09565	COG0308	aminopeptidase N
IUD23_09620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IUD23_09635	COG1758	RNA polymerase activity
IUD23_09645	COG1561	YicC-like family, N-terminal region
IUD23_09660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IUD23_09705	COG5295	Hep Hag repeat protein
IUD23_09710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IUD23_09715	COG1459	type II secretion system
IUD23_09720	COG2165	general secretion pathway protein
IUD23_09725	COG4970	Tfp pilus assembly protein FimT
IUD23_09730	COG2165	general secretion pathway protein
IUD23_09735	COG4795	General secretion pathway protein
IUD23_09740	COG3156	type II secretion system protein K
IUD23_09745	COG3166	PFAM Fimbrial assembly family protein
IUD23_09760	COG1450	Type ii and iii secretion system protein
IUD23_09780	COG3634	alkyl hydroperoxide reductase activity
IUD23_09785	COG0583	DNA-binding transcription factor activity
IUD23_09850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IUD23_09875	COG0567	Dehydrogenase, E1 component
IUD23_09880	COG2850	peptidyl-arginine hydroxylation
IUD23_09985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IUD23_09990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IUD23_09995	COG2902	Dehydrogenase
IUD23_10090	COG0675	Transposase, IS605 OrfB family
IUD23_10110	COG3657	addiction module killer protein
IUD23_10125	COG3609	addiction module antidote protein, CC2985 family
IUD23_10135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IUD23_10165	COG2925	Exonuclease
IUD23_10175	COG0025	NhaP-type Na H and K H
IUD23_10195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IUD23_10220	COG0006	proline dipeptidase activity
IUD23_10230	COG0778	Nitroreductase
IUD23_10265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IUD23_10305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IUD23_10315	COG0557	exoribonuclease II activity
IUD23_10325	COG0582	viral genome integration into host DNA
IUD23_10330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IUD23_10345	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IUD23_10350	COG1289	transmembrane transporter activity
IUD23_10365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IUD23_10375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUD23_10395	COG0596	Alpha beta hydrolase
IUD23_10400	COG0727	PFAM Uncharacterised protein family (UPF0153)
IUD23_10445	COG0840	transmembrane signaling receptor activity
IUD23_10450	COG0643	Histidine kinase
IUD23_10450	COG2198	Histidine kinase
IUD23_10450	COG0784	Response regulator, receiver
IUD23_10480	COG0285	dihydrofolate synthase activity
IUD23_10490	COG0339	signal peptide processing
IUD23_10510	COG1301	dicarboxylic acid transport
IUD23_10515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IUD23_10525	COG2091	lysine biosynthetic process via aminoadipic acid
IUD23_10570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IUD23_10625	COG0084	hydrolase, TatD family'
IUD23_10640	COG0552	protein localization to endoplasmic reticulum
IUD23_10685	COG0824	Thioesterase
IUD23_10710	COG2885	chlorophyll binding
IUD23_10720	COG0602	queuosine metabolic process
IUD23_10740	COG0386	Belongs to the glutathione peroxidase family
IUD23_10760	COG0406	alpha-ribazole phosphatase activity
IUD23_10970	COG0675	Transposase, IS605 OrfB family
IUD23_10985	COG3852	Histidine kinase
IUD23_10990	COG2204	response regulator
IUD23_11005	COG0004	ammonium transporteR
IUD23_11010	COG0347	Belongs to the P(II) protein family
IUD23_11015	COG0174	glutamine synthetase
IUD23_11020	COG1968	undecaprenyl-diphosphatase activity
IUD23_11025	COG2353	YceI-like domain
IUD23_11085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IUD23_11090	COG1764	response to oxidative stress
IUD23_11095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IUD23_11130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IUD23_11140	COG1399	metal-binding, possibly nucleic acid-binding protein
IUD23_11150	COG0714	Associated with various cellular activities
IUD23_11170	COG0537	adenosine 5'-monophosphoramidase activity
IUD23_11230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IUD23_11255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IUD23_11255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IUD23_11320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IUD23_11335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IUD23_11350	COG0251	oxidation-reduction process
IUD23_11355	COG0392	lysyltransferase activity
IUD23_11355	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IUD23_11365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IUD23_11375	COG0463	Glycosyl transferase, family 2
IUD23_11420	COG3275	phosphorelay sensor kinase activity
IUD23_11425	COG0400	carboxylic ester hydrolase activity
IUD23_11445	COG2226	methyltransferase
IUD23_11465	COG2027	D-alanyl-D-alanine carboxypeptidase
IUD23_11470	COG2027	D-alanyl-D-alanine carboxypeptidase
IUD23_11510	COG0386	Belongs to the glutathione peroxidase family
IUD23_11515	COG1131	(ABC) transporter
IUD23_11630	COG0675	Transposase, IS605 OrfB family
IUD23_11675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IUD23_11680	COG0488	(ABC) transporter
IUD23_11700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IUD23_11700	COG4651	solute:proton antiporter activity
IUD23_11760	COG0859	PFAM glycosyl transferase family 9
IUD23_11775	COG0631	protein serine/threonine phosphatase activity
IUD23_11780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IUD23_11785	COG0328	RNA-DNA hybrid ribonuclease activity
IUD23_11810	COG2183	response to ionizing radiation
IUD23_11825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IUD23_11830	COG3118	belongs to the thioredoxin family
IUD23_11870	COG2951	lytic endotransglycosylase activity
IUD23_11875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IUD23_12005	COG3505	Type IV secretory pathway VirD4
IUD23_12025	COG3736	Type IV secretory pathway, component VirB8