locus-tag	class	description
PLS229_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PLS229_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PLS229_00020	COG0187	DNA topoisomerase II activity
PLS229_00030	COG0501	Belongs to the peptidase M48B family
PLS229_00075	COG0408	coproporphyrinogen oxidase activity
PLS229_00100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PLS229_00175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PLS229_00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PLS229_00195	COG0511	ligase activity, forming carbon-carbon bonds
PLS229_00200	COG0439	Biotin carboxylase
PLS229_00205	COG0210	DNA helicase
PLS229_00240	COG1040	competence protein
PLS229_00245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PLS229_00250	COG1752	Esterase of the alpha-beta hydrolase superfamily
PLS229_00255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PLS229_00270	COG2027	D-alanyl-D-alanine carboxypeptidase
PLS229_00305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PLS229_00315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PLS229_00340	COG3121	Chaperone
PLS229_00345	COG3539	Fimbrial protein
PLS229_00350	COG1546	Belongs to the CinA family
PLS229_00355	COG0477	Major facilitator Superfamily
PLS229_00360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PLS229_00365	COG1923	regulation of RNA biosynthetic process
PLS229_00375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PLS229_00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PLS229_00390	COG1534	Rna-binding protein
PLS229_00405	COG0129	dihydroxy-acid dehydratase activity
PLS229_00435	COG1560	Kdo2-lipid A biosynthetic process
PLS229_00440	COG1519	Transferase
PLS229_00455	COG0228	four-way junction DNA binding
PLS229_00460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PLS229_00465	COG0336	Belongs to the RNA methyltransferase TrmD family
PLS229_00470	COG0335	large ribosomal subunit rRNA binding
PLS229_00490	COG1393	Belongs to the ArsC family
PLS229_00500	COG0367	asparagine synthase
PLS229_00510	COG2070	2-Nitropropane dioxygenase
PLS229_00530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PLS229_00545	COG0339	signal peptide processing
PLS229_00570	COG0525	valine-tRNA ligase activity
PLS229_00610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PLS229_00635	COG4221	oxidoreductase activity
PLS229_00645	COG0018	arginyl-trna synthetase
PLS229_00650	COG2003	Belongs to the UPF0758 family
PLS229_00655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PLS229_00720	COG2223	nitrite transmembrane transporter activity
PLS229_00725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PLS229_00730	COG0739	heme binding
PLS229_00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PLS229_00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PLS229_00790	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_00800	COG1272	protein, Hemolysin III
PLS229_00805	COG0463	Glycosyl transferase, family 2
PLS229_00810	COG0084	hydrolase, TatD family'
PLS229_00825	COG0509	glycine decarboxylation via glycine cleavage system
PLS229_00830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PLS229_00840	COG0330	HflC and HflK could
PLS229_00845	COG3956	TIGRFAM MazG family protein
PLS229_00850	COG1218	3'(2'),5'-bisphosphate nucleotidase
PLS229_00855	COG0494	nUDIX hydrolase
PLS229_00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PLS229_00875	COG0513	Belongs to the DEAD box helicase family
PLS229_00880	COG0720	synthase
PLS229_00915	COG0587	DNA-directed DNA polymerase activity
PLS229_00925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PLS229_00930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PLS229_00945	COG0512	Glutamine amidotransferase of anthranilate synthase
PLS229_00950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PLS229_00995	COG0006	proline dipeptidase activity
PLS229_01020	COG1862	Preprotein translocase
PLS229_01025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PLS229_01030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PLS229_01040	COG0617	tRNA 3'-terminal CCA addition
PLS229_01055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PLS229_01060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PLS229_01065	COG0166	Belongs to the GPI family
PLS229_01075	COG0779	Required for maturation of 30S ribosomal subunits
PLS229_01080	COG0195	Participates in both transcription termination and antitermination
PLS229_01085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PLS229_01090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PLS229_01095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PLS229_01105	COG1185	polyribonucleotide nucleotidyltransferase activity
PLS229_01110	COG1733	regulation of RNA biosynthetic process
PLS229_01115	COG0702	epimerase
PLS229_01130	COG0475	glutathione-regulated potassium exporter activity
PLS229_01160	COG2086	electron transfer activity
PLS229_01190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PLS229_01250	COG0477	Major facilitator Superfamily
PLS229_01275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PLS229_01280	COG0671	phosphoesterase, PA-phosphatase related
PLS229_01310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PLS229_01320	COG0628	permease
PLS229_01340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PLS229_01345	COG1090	epimerase
PLS229_01350	COG0318	PFAM AMP-dependent synthetase and ligase
PLS229_01370	COG1049	propionate catabolic process, 2-methylcitrate cycle
PLS229_01385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PLS229_01390	COG0732	type I restriction modification DNA specificity domain
PLS229_01400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PLS229_01435	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PLS229_01445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PLS229_01455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
PLS229_01460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PLS229_01465	COG1034	ATP synthesis coupled electron transport
PLS229_01500	COG1007	ATP synthesis coupled electron transport
PLS229_01505	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_01510	COG2851	Citrate transporter
PLS229_01525	COG0642	Histidine kinase
PLS229_01540	COG2205	protein histidine kinase activity
PLS229_01540	COG2198	Histidine kinase
PLS229_01540	COG0784	Response regulator, receiver
PLS229_01550	COG1301	dicarboxylic acid transport
PLS229_01555	COG0281	malic enzyme
PLS229_01555	COG0280	phosphate acetyltransferase
PLS229_01565	COG0742	ribosomal rna small subunit methyltransferase
PLS229_01580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PLS229_01590	COG3706	GGDEF domain
PLS229_01600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PLS229_01605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PLS229_01635	COG2166	iron-sulfur cluster assembly
PLS229_01640	COG0215	cysteine-tRNA ligase activity
PLS229_01660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PLS229_01680	COG0165	Argininosuccinate lyase
PLS229_01695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PLS229_01730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PLS229_01795	COG5314	conjugation
PLS229_01835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PLS229_01850	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_01870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PLS229_01950	COG1914	H( )-stimulated, divalent metal cation uptake system
PLS229_01965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PLS229_01975	COG1946	Acyl-CoA thioesterase
PLS229_02055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PLS229_02070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PLS229_02090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PLS229_02095	COG0575	Belongs to the CDS family
PLS229_02135	COG2833	Protein of unknown function (DUF455)
PLS229_02140	COG0528	UMP kinase activity
PLS229_02215	COG0800	Aldolase
PLS229_02225	COG0363	glucosamine-6-phosphate deaminase activity
PLS229_02230	COG0837	glucose binding
PLS229_02235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PLS229_02240	COG3842	ATPase activity
PLS229_02260	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PLS229_02275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PLS229_02285	COG4591	ABC-type transport system involved in lipoprotein release permease component
PLS229_02290	COG1136	(ABC) transporter
PLS229_02295	COG2333	competence protein COMEC
PLS229_02295	COG0658	competence protein
PLS229_02315	COG1663	tetraacyldisaccharide 4'-kinase activity
PLS229_02320	COG0489	protein tyrosine kinase activity
PLS229_02325	COG2062	phosphohistidine phosphatase, SixA
PLS229_02335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PLS229_02375	COG0009	L-threonylcarbamoyladenylate synthase
PLS229_02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PLS229_02380	COG1754	DNA topoisomerase type I activity
PLS229_02390	COG2922	Belongs to the Smg family
PLS229_02395	COG0758	DNA mediated transformation
PLS229_02410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PLS229_02420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PLS229_02485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PLS229_02560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PLS229_02565	COG0505	Belongs to the CarA family
PLS229_02570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PLS229_02575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PLS229_02585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PLS229_02595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PLS229_02610	COG1024	Enoyl-CoA hydratase
PLS229_02615	COG0527	aspartate kinase activity
PLS229_02625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PLS229_02645	COG0494	nUDIX hydrolase
PLS229_02655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PLS229_02670	COG1530	ribonuclease E activity
PLS229_02680	COG0312	modulator of DNA gyrase
PLS229_02685	COG3028	Belongs to the UPF0307 family
PLS229_02690	COG0312	modulator of DNA gyrase
PLS229_02715	COG0583	DNA-binding transcription factor activity
PLS229_02730	COG1064	alcohol dehydrogenase
PLS229_02745	COG0667	Aldo Keto reductase
PLS229_02775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PLS229_02805	COG0356	it plays a direct role in the translocation of protons across the membrane
PLS229_02830	COG0089	rRNA binding
PLS229_02840	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PLS229_02845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PLS229_02850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PLS229_02910	COG1841	ribosomal large subunit assembly
PLS229_02915	COG0200	Binds to the 23S rRNA
PLS229_02920	COG0201	protein transport
PLS229_02925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PLS229_02930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PLS229_02950	COG2960	long-chain fatty acid transporting porin activity
PLS229_02955	COG0606	chelatase, subunit chli
PLS229_02975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PLS229_02990	COG0544	peptidyl-prolyl cis-trans isomerase activity
PLS229_02995	COG0740	serine-type endopeptidase activity
PLS229_03000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PLS229_03035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PLS229_03040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PLS229_03065	COG1187	pseudouridine synthase activity
PLS229_03070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PLS229_03090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PLS229_03145	COG3772	lysozyme
PLS229_03185	COG0625	glutathione transferase activity
PLS229_03195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PLS229_03245	COG0842	Transport permease protein
PLS229_03250	COG1131	(ABC) transporter
PLS229_03270	COG1643	Atp-dependent helicase
PLS229_03280	COG1956	GAF domain-containing protein
PLS229_03285	COG0729	surface antigen
PLS229_03290	COG2911	Protein conserved in bacteria
PLS229_03340	COG1937	Protein conserved in bacteria
PLS229_03375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PLS229_03380	COG0668	transmembrane transport
PLS229_03410	COG2733	membrane
PLS229_03425	COG2921	Belongs to the UPF0250 family
PLS229_03430	COG0321	lipoyl(octanoyl) transferase activity
PLS229_03435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PLS229_03460	COG1253	flavin adenine dinucleotide binding
PLS229_03485	COG0504	CTP synthase activity
PLS229_03490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PLS229_03495	COG0148	phosphopyruvate hydratase activity
PLS229_03510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PLS229_03515	COG2840	Smr protein MutS2
PLS229_03525	COG0644	oxidoreductase
PLS229_03525	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
PLS229_03540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PLS229_03540	COG3218	ABC-type transport auxiliary lipoprotein component
PLS229_03545	COG1127	ABC transporter
PLS229_03550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PLS229_03615	COG1077	Cell shape determining protein MreB Mrl
PLS229_03620	COG1792	Involved in formation and maintenance of cell shape
PLS229_03625	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PLS229_03630	COG0768	penicillin binding
PLS229_03635	COG0772	Belongs to the SEDS family
PLS229_03645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PLS229_03665	COG2894	cell division
PLS229_03670	COG0850	regulation of cytokinetic process
PLS229_03690	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PLS229_03700	COG3038	cytochrome b561
PLS229_03705	COG2353	YceI-like domain
PLS229_03710	COG5002	protein histidine kinase activity
PLS229_03710	COG0784	Response regulator, receiver
PLS229_03720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PLS229_03745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PLS229_03775	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PLS229_03780	COG4208	sulfate ABC transporter
PLS229_03905	COG5532	Uncharacterized conserved protein (DUF2303)
PLS229_03930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PLS229_03950	COG1566	PFAM secretion protein HlyD family protein
PLS229_03955	COG2814	Major facilitator Superfamily
PLS229_03960	COG2267	carboxylic ester hydrolase activity
PLS229_03980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PLS229_03985	COG0617	tRNA 3'-terminal CCA addition
PLS229_03990	COG0741	lytic transglycosylase activity
PLS229_04070	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_04085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PLS229_04090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PLS229_04110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PLS229_04115	COG0483	inositol monophosphate 1-phosphatase activity
PLS229_04125	COG1509	lysine 2,3-aminomutase activity
PLS229_04135	COG0402	S-adenosylhomocysteine deaminase activity
PLS229_04140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PLS229_04145	COG0546	phosphoglycolate phosphatase activity
PLS229_04155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PLS229_04195	COG0436	Aminotransferase
PLS229_04210	COG1187	pseudouridine synthase activity
PLS229_04215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PLS229_04220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PLS229_04255	COG0395	ABC-type sugar transport system, permease component
PLS229_04270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PLS229_04275	COG2957	Belongs to the agmatine deiminase family
PLS229_04300	COG0776	regulation of translation
PLS229_04310	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PLS229_04325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PLS229_04330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PLS229_04395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PLS229_04405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PLS229_04410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PLS229_04415	COG0268	Binds directly to 16S ribosomal RNA
PLS229_04420	COG0728	peptidoglycan biosynthetic process
PLS229_04425	COG0196	riboflavin kinase activity
PLS229_04430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PLS229_04455	COG1396	sequence-specific DNA binding
PLS229_04495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PLS229_04495	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PLS229_04570	COG0436	Aminotransferase
PLS229_04580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PLS229_04600	COG1902	pentaerythritol trinitrate reductase activity
PLS229_04620	COG1064	alcohol dehydrogenase
PLS229_04625	COG0604	alcohol dehydrogenase
PLS229_04650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PLS229_04655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PLS229_04685	COG0473	3-isopropylmalate dehydrogenase activity
PLS229_04715	COG0438	transferase activity, transferring glycosyl groups
PLS229_04725	COG2244	polysaccharide biosynthetic process
PLS229_04730	COG0438	transferase activity, transferring glycosyl groups
PLS229_04745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PLS229_04750	COG2954	triphosphatase activity
PLS229_04755	COG1472	Belongs to the glycosyl hydrolase 3 family
PLS229_04770	COG1278	Cold shock
PLS229_04795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_04805	COG0497	DNA recombination
PLS229_04820	COG0443	Heat shock 70 kDa protein
PLS229_04825	COG0484	heat shock protein binding
PLS229_04840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PLS229_04850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PLS229_04865	COG0745	RESPONSE REGULATOR receiver
PLS229_04870	COG2205	protein histidine kinase activity
PLS229_04880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
PLS229_04885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
PLS229_04905	COG2967	ApaG domain
PLS229_04915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PLS229_04920	COG0704	Plays a role in the regulation of phosphate uptake
PLS229_04930	COG0581	inorganic phosphate transmembrane transporter activity
PLS229_04935	COG0573	inorganic phosphate transmembrane transporter activity
PLS229_04940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PLS229_04945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PLS229_04945	COG4651	solute:proton antiporter activity
PLS229_04955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PLS229_04965	COG0488	(ABC) transporter
PLS229_04990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PLS229_05000	COG0489	protein tyrosine kinase activity
PLS229_05025	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PLS229_05030	COG1414	Transcriptional regulator
PLS229_05080	COG1469	GTP cyclohydrolase I activity
PLS229_05090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PLS229_05095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PLS229_05100	COG2902	Dehydrogenase
PLS229_05105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PLS229_05135	COG2925	Exonuclease
PLS229_05150	COG0025	NhaP-type Na H and K H
PLS229_05170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PLS229_05190	COG3079	Belongs to the UPF0149 family
PLS229_05195	COG0006	proline dipeptidase activity
PLS229_05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PLS229_05295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PLS229_05320	COG3772	lysozyme
PLS229_05380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PLS229_05390	COG0328	RNA-DNA hybrid ribonuclease activity
PLS229_05395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PLS229_05415	COG0859	PFAM glycosyl transferase family 9
PLS229_05425	COG2943	transferase activity, transferring hexosyl groups
PLS229_05430	COG0400	carboxylic ester hydrolase activity
PLS229_05435	COG3275	phosphorelay sensor kinase activity
PLS229_05480	COG0463	Glycosyl transferase, family 2
PLS229_05490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PLS229_05505	COG0392	lysyltransferase activity
PLS229_05505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PLS229_05510	COG0251	oxidation-reduction process
PLS229_05525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PLS229_05530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PLS229_05535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PLS229_05540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PLS229_05560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PLS229_05615	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PLS229_05725	COG0582	viral genome integration into host DNA
PLS229_05740	COG3772	lysozyme
PLS229_05795	COG0640	Transcriptional regulator
PLS229_05810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PLS229_05835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PLS229_05870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PLS229_05875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PLS229_05885	COG0537	adenosine 5'-monophosphoramidase activity
PLS229_05905	COG0714	Associated with various cellular activities
PLS229_05915	COG1399	metal-binding, possibly nucleic acid-binding protein
PLS229_05920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PLS229_05925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PLS229_05940	COG5297	Belongs to the glycosyl hydrolase family 6
PLS229_05945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PLS229_05965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PLS229_05975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PLS229_05980	COG1764	response to oxidative stress
PLS229_05985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PLS229_05990	COG2945	thiolester hydrolase activity
PLS229_06050	COG2353	YceI-like domain
PLS229_06055	COG1968	undecaprenyl-diphosphatase activity
PLS229_06060	COG0174	glutamine synthetase
PLS229_06065	COG0347	Belongs to the P(II) protein family
PLS229_06070	COG0004	ammonium transporteR
PLS229_06095	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PLS229_06100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PLS229_06105	COG0084	hydrolase, TatD family'
PLS229_06140	COG0552	protein localization to endoplasmic reticulum
PLS229_06160	COG0217	transcriptional regulatory protein
PLS229_06175	COG3158	transport of potassium into the cell
PLS229_06185	COG0824	Thioesterase
PLS229_06190	COG0811	peptide transport
PLS229_06195	COG0848	biopolymer transport protein
PLS229_06210	COG2885	chlorophyll binding
PLS229_06220	COG0602	queuosine metabolic process
PLS229_06230	COG1515	deoxyribonuclease V activity
PLS229_06235	COG3104	oligopeptide transport
PLS229_06240	COG0386	Belongs to the glutathione peroxidase family
PLS229_06250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PLS229_06260	COG0406	alpha-ribazole phosphatase activity
PLS229_06270	COG1487	ribonuclease activity
PLS229_06345	COG3041	Addiction module toxin RelE StbE family
PLS229_06350	COG3077	Addiction module antitoxin, RelB DinJ family
PLS229_06425	COG2337	Toxic component of a toxin-antitoxin (TA) module
PLS229_06490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PLS229_06530	COG2091	lysine biosynthetic process via aminoadipic acid
PLS229_06540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PLS229_06545	COG1301	dicarboxylic acid transport
PLS229_06570	COG0339	signal peptide processing
PLS229_06580	COG0285	dihydrofolate synthase activity
PLS229_06605	COG2201	protein-glutamate methylesterase activity
PLS229_06610	COG0643	Histidine kinase
PLS229_06610	COG0784	Response regulator, receiver
PLS229_06610	COG2198	Histidine kinase
PLS229_06615	COG0840	transmembrane signaling receptor activity
PLS229_06645	COG0751	glycine-tRNA ligase activity
PLS229_06655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PLS229_06655	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PLS229_06675	COG0727	PFAM Uncharacterised protein family (UPF0153)
PLS229_06685	COG0596	Alpha beta hydrolase
PLS229_06695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PLS229_06705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PLS229_06715	COG0138	bifunctional purine biosynthesis protein purh
PLS229_06720	COG0151	Belongs to the GarS family
PLS229_06740	COG1289	transmembrane transporter activity
PLS229_06750	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PLS229_06760	COG0302	gtp cyclohydrolase
PLS229_06770	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PLS229_06780	COG0557	exoribonuclease II activity
PLS229_06785	COG3617	BRO family, N-terminal domain
PLS229_06790	COG3772	lysozyme
PLS229_06850	COG2183	response to ionizing radiation
PLS229_06880	COG1881	PFAM PEBP family protein
PLS229_06885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PLS229_06890	COG3118	belongs to the thioredoxin family
PLS229_06900	COG0495	leucyl-tRNA aminoacylation
PLS229_06930	COG2951	lytic endotransglycosylase activity
PLS229_07075	COG3210	domain, Protein
PLS229_07180	COG3210	domain, Protein
PLS229_07205	COG1280	lysine exporter protein (LysE YggA)
PLS229_07225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PLS229_07230	COG0277	FAD linked oxidase domain protein
PLS229_07235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PLS229_07240	COG0531	amino acid
PLS229_07245	COG0531	amino acid
PLS229_07250	COG0235	Class ii aldolase
PLS229_07255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PLS229_07260	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
PLS229_07305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PLS229_07305	COG0131	Imidazoleglycerol-phosphate dehydratase
PLS229_07315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PLS229_07320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PLS229_07340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PLS229_07345	COG0083	homoserine kinase activity
PLS229_07350	COG0460	homoserine dehydrogenase
PLS229_07350	COG0527	aspartate kinase activity
PLS229_07360	COG0540	Belongs to the ATCase OTCase family
PLS229_07375	COG1686	Belongs to the peptidase S11 family
PLS229_07380	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PLS229_07395	COG4953	penicillin-binding protein 1C
PLS229_07435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PLS229_07460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PLS229_07465	COG1381	Involved in DNA repair and RecF pathway recombination
PLS229_07480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PLS229_07490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PLS229_07500	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_07515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_07520	COG1506	peptidase
PLS229_07520	COG0823	Involved in the tonB-independent uptake of proteins
PLS229_07525	COG1297	OPT oligopeptide transporter protein
PLS229_07550	COG0676	glucose-6-phosphate 1-epimerase activity
PLS229_07560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PLS229_07570	COG0318	PFAM AMP-dependent synthetase and ligase
PLS229_07580	COG0463	Glycosyl transferase, family 2
PLS229_07590	COG1475	DNA binding
PLS229_07595	COG1192	Involved in chromosome partitioning
PLS229_07610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PLS229_07625	COG1605	Chorismate mutase
PLS229_07625	COG0077	Prephenate dehydratase
PLS229_07640	COG1668	transmembrane transport
PLS229_07645	COG4555	ABC transporter
PLS229_07675	COG1309	transcriptional regulator
PLS229_07680	COG2226	methyltransferase
PLS229_07690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PLS229_07705	COG2900	Belongs to the SlyX family
PLS229_07720	COG0386	Belongs to the glutathione peroxidase family
PLS229_07730	COG1131	(ABC) transporter
PLS229_07755	COG2850	peptidyl-arginine hydroxylation
PLS229_07760	COG0567	Dehydrogenase, E1 component
PLS229_07785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PLS229_07810	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
PLS229_07840	COG0583	DNA-binding transcription factor activity
PLS229_07845	COG3634	alkyl hydroperoxide reductase activity
PLS229_07855	COG5295	Hep Hag repeat protein
PLS229_07860	COG1450	Type ii and iii secretion system protein
PLS229_07875	COG3166	PFAM Fimbrial assembly family protein
PLS229_07880	COG3156	type II secretion system protein K
PLS229_07895	COG3156	type II secretion system protein K
PLS229_07900	COG4795	General secretion pathway protein
PLS229_07905	COG2165	general secretion pathway protein
PLS229_07910	COG4970	Tfp pilus assembly protein FimT
PLS229_07915	COG2165	general secretion pathway protein
PLS229_07920	COG1459	type II secretion system
PLS229_07925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PLS229_07970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PLS229_07985	COG1561	YicC-like family, N-terminal region
PLS229_07990	COG0194	GDP metabolic process
PLS229_07995	COG1758	RNA polymerase activity
PLS229_08000	COG0529	Catalyzes the synthesis of activated sulfate
PLS229_08000	COG2895	sulfate adenylyltransferase (ATP) activity
PLS229_08005	COG0175	sulfate reduction
PLS229_08020	COG0175	sulfate reduction
PLS229_08070	COG0308	aminopeptidase N
PLS229_08075	COG2226	methyltransferase
PLS229_08130	COG1959	2 iron, 2 sulfur cluster binding
PLS229_08135	COG0719	Fe-S assembly protein
PLS229_08140	COG0396	ATPase activity
PLS229_08145	COG0719	Fe-S assembly protein
PLS229_08150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PLS229_08155	COG2146	nitrite reductase [NAD(P)H] activity
PLS229_08160	COG0297	glycogen (starch) synthase activity
PLS229_08165	COG0726	polysaccharide deacetylase
PLS229_08170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PLS229_08175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PLS229_08195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PLS229_08200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PLS229_08220	COG0837	glucose binding
PLS229_08245	COG4191	Histidine kinase
PLS229_08265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PLS229_08270	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PLS229_08285	COG1674	ftsk spoiiie
PLS229_08290	COG0492	ferredoxin-NADP+ reductase activity
PLS229_08300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PLS229_08305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PLS229_08310	COG0542	response to heat
PLS229_08330	COG2915	High frequency lysogenization protein hflD homolog
PLS229_08375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PLS229_08385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PLS229_08390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PLS229_08390	COG0047	phosphoribosylformylglycinamidine synthase activity
PLS229_08400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PLS229_08405	COG0271	Belongs to the BolA IbaG family
PLS229_08415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
PLS229_08430	COG1137	ATPase activity
PLS229_08450	COG1660	Displays ATPase and GTPase activities
PLS229_08460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PLS229_08465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PLS229_08470	COG2239	Acts as a magnesium transporter
PLS229_08485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PLS229_08510	COG1595	DNA-templated transcription, initiation
PLS229_08535	COG0142	geranyltranstransferase activity
PLS229_08545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PLS229_08550	COG1845	cytochrome c oxidase, subunit III
PLS229_08555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PLS229_08560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PLS229_08560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PLS229_08570	COG1643	Atp-dependent helicase
PLS229_08575	COG0783	Belongs to the Dps family
PLS229_08580	COG0514	ATP-dependent DNA helicase (RecQ)
PLS229_08600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PLS229_08645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PLS229_08725	COG0142	geranyltranstransferase activity
PLS229_08730	COG1722	exodeoxyribonuclease VII activity
PLS229_08735	COG0037	tRNA processing
PLS229_08745	COG1301	dicarboxylic acid transport
PLS229_08750	COG0791	NLP P60 protein
PLS229_08755	COG0791	NLP P60 protein
PLS229_08765	COG2311	Membrane
PLS229_08790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PLS229_08805	COG0545	Peptidyl-prolyl cis-trans isomerase
PLS229_08810	COG0494	nUDIX hydrolase
PLS229_08820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PLS229_08835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PLS229_08840	COG0351	phosphomethylpyrimidine kinase
PLS229_08840	COG0352	thiamine-phosphate diphosphorylase activity
PLS229_08865	COG1324	tolerance protein
PLS229_08900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PLS229_08905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PLS229_08910	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
PLS229_08925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PLS229_08945	COG4774	siderophore transport
PLS229_08970	COG1477	protein flavinylation
PLS229_08975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PLS229_08980	COG1555	photosystem II stabilization
PLS229_08990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PLS229_09000	COG0628	permease
PLS229_09010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PLS229_09015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PLS229_09035	COG3590	peptidase
PLS229_09040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PLS229_09070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PLS229_09090	COG0519	Catalyzes the synthesis of GMP from XMP
PLS229_09090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PLS229_09095	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
PLS229_09100	COG1162	GTPase activity
PLS229_09110	COG3107	peptidoglycan biosynthetic process
PLS229_09135	COG2878	Part of a membrane complex involved in electron transport
PLS229_09230	COG1611	Belongs to the LOG family
PLS229_09235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
PLS229_09245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PLS229_09250	COG1160	GTP binding
PLS229_09255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_09285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PLS229_09300	COG0330	HflC and HflK could
PLS229_09305	COG0330	HflC and HflK could
PLS229_09310	COG0604	alcohol dehydrogenase
PLS229_09340	COG1183	phosphatidylcholine synthase activity
PLS229_09350	COG0456	acetyltransferase
PLS229_09370	COG0668	transmembrane transport
PLS229_09375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PLS229_09390	COG1610	YqeY-like protein
PLS229_09395	COG1295	ribonuclease BN
PLS229_09400	COG0358	DNA primase activity
PLS229_09410	COG0180	Tryptophanyl-tRNA synthetase
PLS229_09420	COG1074	ATP-dependent DNA helicase activity
PLS229_09425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PLS229_09430	COG1127	ABC transporter
PLS229_09435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PLS229_09440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PLS229_09455	COG2853	Lipoprotein
PLS229_09465	COG1116	anion transmembrane transporter activity
PLS229_09480	COG0531	amino acid
PLS229_09490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PLS229_09495	COG0861	Integral membrane protein TerC family
PLS229_09570	COG2205	protein histidine kinase activity
PLS229_09575	COG0745	RESPONSE REGULATOR receiver
PLS229_09585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PLS229_09635	COG2124	cytochrome p450
PLS229_09665	COG0305	Participates in initiation and elongation during chromosome replication
PLS229_09680	COG0667	Aldo Keto reductase
PLS229_09685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PLS229_09720	COG2194	sulfuric ester hydrolase activity
PLS229_09725	COG2124	cytochrome p450
PLS229_09730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PLS229_09740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PLS229_09750	COG0277	FAD linked oxidase domain protein
PLS229_09765	COG4206	TonB-dependent receptor
PLS229_09810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PLS229_09815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PLS229_09845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PLS229_09865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PLS229_09865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PLS229_09885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PLS229_09890	COG0488	(ABC) transporter
PLS229_09900	COG3011	Protein conserved in bacteria
PLS229_09910	COG0564	pseudouridine synthase activity
PLS229_09915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PLS229_09935	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_09940	COG2969	positive regulation of protein catabolic process
PLS229_09945	COG0625	glutathione transferase activity
PLS229_09965	COG0741	lytic transglycosylase activity
PLS229_09975	COG1702	phosphate starvation-inducible protein PhoH
PLS229_09990	COG4535	Mg2 and Co2 transporter CorC
PLS229_10025	COG3210	domain, Protein
PLS229_10030	COG2831	hemolysin activation secretion protein
PLS229_10055	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PLS229_10075	COG3115	cell septum assembly
PLS229_10090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PLS229_10100	COG0316	Belongs to the HesB IscA family
PLS229_10125	COG0167	dihydroorotate dehydrogenase activity
PLS229_10130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PLS229_10135	COG0697	spore germination
PLS229_10140	COG0671	phosphoesterase, PA-phosphatase related
PLS229_10145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PLS229_10155	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
PLS229_10160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PLS229_10180	COG1132	(ABC) transporter
PLS229_10195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PLS229_10200	COG1538	Outer membrane efflux protein
PLS229_10205	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PLS229_10215	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PLS229_10230	COG4783	chaperone-mediated protein folding
PLS229_10240	COG0473	3-isopropylmalate dehydrogenase activity
PLS229_10250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PLS229_10260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PLS229_10270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PLS229_10270	COG0316	Belongs to the HesB IscA family
PLS229_10275	COG2154	pterin-4-alpha-carbinolamine dehydratase
PLS229_10290	COG0564	pseudouridine synthase activity
PLS229_10295	COG1530	ribonuclease E activity
PLS229_10315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PLS229_10340	COG1278	Cold shock
PLS229_10355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PLS229_10365	COG0049	tRNA binding
PLS229_10380	COG0085	RNA polymerase activity
PLS229_10385	COG0222	ribosome binding
PLS229_10400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PLS229_10405	COG0250	Participates in transcription elongation, termination and antitermination
PLS229_10410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PLS229_10420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PLS229_10440	COG0012	GTP binding
PLS229_10445	COG0193	aminoacyl-tRNA hydrolase activity
PLS229_10450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PLS229_10455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PLS229_10465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PLS229_10470	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PLS229_10480	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PLS229_10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PLS229_10565	COG0765	amino acid transport
PLS229_10570	COG1126	abc transporter atp-binding protein
PLS229_10575	COG0765	amino acid transport
PLS229_10585	COG2095	MarC family integral membrane protein
PLS229_10590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PLS229_10620	COG2132	Multicopper oxidase
PLS229_10630	COG0210	DNA helicase
PLS229_10640	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
PLS229_10645	COG0616	signal peptide processing
PLS229_10665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PLS229_10670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PLS229_10675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PLS229_10685	COG2177	Part of the ABC transporter FtsEX involved in
PLS229_10690	COG2884	Cell division ATP-binding protein ftsE
PLS229_10695	COG0513	Belongs to the DEAD box helicase family
PLS229_10700	COG3118	belongs to the thioredoxin family
PLS229_10705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PLS229_10740	COG0793	Belongs to the peptidase S41A family
PLS229_10745	COG4942	peptidase
PLS229_10755	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PLS229_10770	COG0493	'glutamate synthase
PLS229_10775	COG0069	glutamate synthase activity
PLS229_10775	COG0067	glutamate synthase
PLS229_10775	COG0070	glutamate synthase
PLS229_10875	COG3210	domain, Protein
PLS229_11015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PLS229_11025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PLS229_11030	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PLS229_11135	COG1028	Short-chain dehydrogenase reductase Sdr
PLS229_11155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PLS229_11165	COG1199	ATP-dependent helicase activity
PLS229_11175	COG0288	reversible hydration of carbon dioxide
PLS229_11180	COG0438	transferase activity, transferring glycosyl groups
PLS229_11195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PLS229_11200	COG2011	ABC-type metal ion transport system permease component
PLS229_11205	COG1464	Belongs to the NlpA lipoprotein family
PLS229_11220	COG0508	dehydrogenase complex catalyzes the overall conversion of
PLS229_11225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PLS229_11240	COG0626	cystathionine gamma-synthase activity
PLS229_11245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PLS229_11250	COG0739	heme binding
PLS229_11255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PLS229_11260	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PLS229_11280	COG5002	protein histidine kinase activity
PLS229_11285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PLS229_11310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
PLS229_11320	COG1472	Belongs to the glycosyl hydrolase 3 family
PLS229_11335	COG3537	Alpha-1,2-mannosidase
PLS229_11355	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PLS229_11370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PLS229_11375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PLS229_11380	COG2207	Transcriptional regulator
PLS229_11385	COG2249	NAD(P)H dehydrogenase (quinone) activity
PLS229_11415	COG3588	fructose-bisphosphate aldolase
PLS229_11425	COG0469	pyruvate kinase activity
PLS229_11445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PLS229_11450	COG0735	belongs to the Fur family
PLS229_11465	COG5297	Belongs to the glycosyl hydrolase family 6
PLS229_11465	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PLS229_11475	COG0612	Peptidase, M16
PLS229_11490	COG4305	rare lipoprotein A
PLS229_11495	COG0653	protein targeting
PLS229_11500	COG0739	heme binding
PLS229_11510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PLS229_11525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PLS229_11530	COG1181	Belongs to the D-alanine--D-alanine ligase family
PLS229_11535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PLS229_11550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PLS229_11555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PLS229_11570	COG3116	cell division
PLS229_11575	COG0275	rRNA processing
PLS229_11585	COG0471	metal ion transport
PLS229_11585	COG3273	potassium ion transport
PLS229_11590	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PLS229_11635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PLS229_11660	COG0717	Belongs to the dCTP deaminase family
PLS229_11675	COG0860	N-Acetylmuramoyl-L-alanine amidase
PLS229_11680	COG0802	atpase or kinase
PLS229_11685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PLS229_11685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PLS229_11690	COG1570	exodeoxyribonuclease VII activity
PLS229_11735	COG0776	regulation of translation
PLS229_11740	COG0072	phenylalanine-tRNA ligase activity
PLS229_11740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PLS229_11745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PLS229_11750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PLS229_11760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PLS229_11780	COG0745	RESPONSE REGULATOR receiver
PLS229_11795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PLS229_11845	COG0045	succinate-CoA ligase (ADP-forming) activity
PLS229_11850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PLS229_11855	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PLS229_11870	COG0594	ribonuclease P activity