locus-tag	class	description
LPH46_00065	COG1487	ribonuclease activity
LPH46_00075	COG0406	alpha-ribazole phosphatase activity
LPH46_00085	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPH46_00095	COG0386	Belongs to the glutathione peroxidase family
LPH46_00105	COG1515	deoxyribonuclease V activity
LPH46_00115	COG0602	queuosine metabolic process
LPH46_00125	COG2885	chlorophyll binding
LPH46_00140	COG0848	biopolymer transport protein
LPH46_00145	COG0811	peptide transport
LPH46_00150	COG0824	Thioesterase
LPH46_00160	COG3158	transport of potassium into the cell
LPH46_00175	COG0217	transcriptional regulatory protein
LPH46_00195	COG0552	protein localization to endoplasmic reticulum
LPH46_00220	COG3041	Addiction module toxin RelE StbE family
LPH46_00225	COG3077	Addiction module antitoxin, RelB DinJ family
LPH46_00300	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPH46_00360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPH46_00395	COG2091	lysine biosynthetic process via aminoadipic acid
LPH46_00405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPH46_00410	COG1301	dicarboxylic acid transport
LPH46_00435	COG0339	signal peptide processing
LPH46_00445	COG0285	dihydrofolate synthase activity
LPH46_00470	COG2201	protein-glutamate methylesterase activity
LPH46_00475	COG0643	Histidine kinase
LPH46_00475	COG0784	Response regulator, receiver
LPH46_00475	COG2198	Histidine kinase
LPH46_00480	COG0840	transmembrane signaling receptor activity
LPH46_00510	COG0751	glycine-tRNA ligase activity
LPH46_00520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH46_00520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPH46_00540	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPH46_00550	COG0596	Alpha beta hydrolase
LPH46_00560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH46_00570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPH46_00580	COG0138	bifunctional purine biosynthesis protein purh
LPH46_00585	COG0151	Belongs to the GarS family
LPH46_00605	COG1289	transmembrane transporter activity
LPH46_00615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPH46_00625	COG0302	gtp cyclohydrolase
LPH46_00635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPH46_00645	COG0557	exoribonuclease II activity
LPH46_00655	COG3772	lysozyme
LPH46_00750	COG1881	PFAM PEBP family protein
LPH46_00755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPH46_00760	COG3118	belongs to the thioredoxin family
LPH46_00770	COG0495	leucyl-tRNA aminoacylation
LPH46_00800	COG2951	lytic endotransglycosylase activity
LPH46_00945	COG3210	domain, Protein
LPH46_01045	COG3210	domain, Protein
LPH46_01065	COG1280	lysine exporter protein (LysE YggA)
LPH46_01085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPH46_01090	COG0277	FAD linked oxidase domain protein
LPH46_01095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPH46_01100	COG0531	amino acid
LPH46_01105	COG0531	amino acid
LPH46_01110	COG0235	Class ii aldolase
LPH46_01115	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPH46_01120	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPH46_01165	COG0131	Imidazoleglycerol-phosphate dehydratase
LPH46_01165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPH46_01175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPH46_01180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPH46_01205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPH46_01210	COG0083	homoserine kinase activity
LPH46_01215	COG0460	homoserine dehydrogenase
LPH46_01215	COG0527	aspartate kinase activity
LPH46_01225	COG0540	Belongs to the ATCase OTCase family
LPH46_01240	COG1686	Belongs to the peptidase S11 family
LPH46_01245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPH46_01260	COG4953	penicillin-binding protein 1C
LPH46_01295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH46_01320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPH46_01325	COG1381	Involved in DNA repair and RecF pathway recombination
LPH46_01340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPH46_01350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPH46_01360	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_01375	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH46_01380	COG0823	Involved in the tonB-independent uptake of proteins
LPH46_01380	COG1506	peptidase
LPH46_01385	COG1297	OPT oligopeptide transporter protein
LPH46_01420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPH46_01430	COG0318	PFAM AMP-dependent synthetase and ligase
LPH46_01440	COG0463	Glycosyl transferase, family 2
LPH46_01450	COG1475	DNA binding
LPH46_01455	COG1192	Involved in chromosome partitioning
LPH46_01470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPH46_01485	COG0077	Prephenate dehydratase
LPH46_01485	COG1605	Chorismate mutase
LPH46_01500	COG1668	transmembrane transport
LPH46_01505	COG4555	ABC transporter
LPH46_01535	COG1309	transcriptional regulator
LPH46_01540	COG2226	methyltransferase
LPH46_01550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPH46_01565	COG2900	Belongs to the SlyX family
LPH46_01580	COG0386	Belongs to the glutathione peroxidase family
LPH46_01590	COG1131	(ABC) transporter
LPH46_01615	COG2850	peptidyl-arginine hydroxylation
LPH46_01620	COG0567	Dehydrogenase, E1 component
LPH46_01645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPH46_01670	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPH46_01700	COG0583	DNA-binding transcription factor activity
LPH46_01705	COG3634	alkyl hydroperoxide reductase activity
LPH46_01715	COG5295	Hep Hag repeat protein
LPH46_01720	COG1450	Type ii and iii secretion system protein
LPH46_01735	COG3166	PFAM Fimbrial assembly family protein
LPH46_01740	COG3156	type II secretion system protein K
LPH46_01750	COG3156	type II secretion system protein K
LPH46_01755	COG4795	General secretion pathway protein
LPH46_01760	COG2165	general secretion pathway protein
LPH46_01765	COG4970	Tfp pilus assembly protein FimT
LPH46_01770	COG2165	general secretion pathway protein
LPH46_01775	COG1459	type II secretion system
LPH46_01780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPH46_01825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPH46_01840	COG1561	YicC-like family, N-terminal region
LPH46_01845	COG0194	GDP metabolic process
LPH46_01850	COG1758	RNA polymerase activity
LPH46_01855	COG2895	sulfate adenylyltransferase (ATP) activity
LPH46_01855	COG0529	Catalyzes the synthesis of activated sulfate
LPH46_01860	COG0175	sulfate reduction
LPH46_01875	COG0175	sulfate reduction
LPH46_01935	COG0308	aminopeptidase N
LPH46_01940	COG2226	methyltransferase
LPH46_01995	COG1959	2 iron, 2 sulfur cluster binding
LPH46_02000	COG0719	Fe-S assembly protein
LPH46_02005	COG0396	ATPase activity
LPH46_02010	COG0719	Fe-S assembly protein
LPH46_02015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPH46_02020	COG2146	nitrite reductase [NAD(P)H] activity
LPH46_02025	COG0297	glycogen (starch) synthase activity
LPH46_02030	COG0726	polysaccharide deacetylase
LPH46_02035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH46_02040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPH46_02060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPH46_02065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH46_02085	COG0837	glucose binding
LPH46_02110	COG4191	Histidine kinase
LPH46_02130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPH46_02135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPH46_02150	COG1674	ftsk spoiiie
LPH46_02155	COG0492	ferredoxin-NADP+ reductase activity
LPH46_02165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPH46_02170	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPH46_02175	COG0542	response to heat
LPH46_02195	COG2915	High frequency lysogenization protein hflD homolog
LPH46_02240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPH46_02250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPH46_02255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPH46_02255	COG0047	phosphoribosylformylglycinamidine synthase activity
LPH46_02265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPH46_02280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPH46_02295	COG1137	ATPase activity
LPH46_02315	COG1660	Displays ATPase and GTPase activities
LPH46_02325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPH46_02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPH46_02335	COG2239	Acts as a magnesium transporter
LPH46_02350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH46_02375	COG1595	DNA-templated transcription, initiation
LPH46_02395	COG0142	geranyltranstransferase activity
LPH46_02405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPH46_02410	COG1845	cytochrome c oxidase, subunit III
LPH46_02415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPH46_02420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH46_02420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH46_02430	COG1643	Atp-dependent helicase
LPH46_02435	COG0783	Belongs to the Dps family
LPH46_02440	COG0514	ATP-dependent DNA helicase (RecQ)
LPH46_02460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPH46_02500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPH46_02585	COG0142	geranyltranstransferase activity
LPH46_02590	COG1722	exodeoxyribonuclease VII activity
LPH46_02595	COG0037	tRNA processing
LPH46_02605	COG1301	dicarboxylic acid transport
LPH46_02610	COG0791	NLP P60 protein
LPH46_02615	COG0791	NLP P60 protein
LPH46_02625	COG2311	Membrane
LPH46_02650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPH46_02665	COG0545	Peptidyl-prolyl cis-trans isomerase
LPH46_02670	COG0494	nUDIX hydrolase
LPH46_02680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPH46_02695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPH46_02700	COG0352	thiamine-phosphate diphosphorylase activity
LPH46_02700	COG0351	phosphomethylpyrimidine kinase
LPH46_02725	COG1324	tolerance protein
LPH46_02760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH46_02765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH46_02770	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPH46_02785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPH46_02805	COG4774	siderophore transport
LPH46_02830	COG1477	protein flavinylation
LPH46_02835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPH46_02840	COG1555	photosystem II stabilization
LPH46_02850	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPH46_02860	COG0628	permease
LPH46_02870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPH46_02875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPH46_02895	COG3590	peptidase
LPH46_02900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH46_02930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPH46_02950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPH46_02950	COG0519	Catalyzes the synthesis of GMP from XMP
LPH46_02955	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LPH46_02960	COG1162	GTPase activity
LPH46_02970	COG3107	peptidoglycan biosynthetic process
LPH46_02995	COG2878	Part of a membrane complex involved in electron transport
LPH46_03090	COG1611	Belongs to the LOG family
LPH46_03095	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPH46_03105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPH46_03110	COG1160	GTP binding
LPH46_03115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH46_03145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPH46_03160	COG0330	HflC and HflK could
LPH46_03165	COG0330	HflC and HflK could
LPH46_03170	COG0604	alcohol dehydrogenase
LPH46_03200	COG1183	phosphatidylcholine synthase activity
LPH46_03210	COG0456	acetyltransferase
LPH46_03230	COG0668	transmembrane transport
LPH46_03235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPH46_03250	COG1610	YqeY-like protein
LPH46_03255	COG1295	ribonuclease BN
LPH46_03260	COG0358	DNA primase activity
LPH46_03270	COG0180	Tryptophanyl-tRNA synthetase
LPH46_03280	COG1074	ATP-dependent DNA helicase activity
LPH46_03285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPH46_03290	COG1127	ABC transporter
LPH46_03295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH46_03300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH46_03315	COG2853	Lipoprotein
LPH46_03325	COG1116	anion transmembrane transporter activity
LPH46_03340	COG0531	amino acid
LPH46_03350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPH46_03355	COG0861	Integral membrane protein TerC family
LPH46_03395	COG4999	Histidine kinase
LPH46_03395	COG3850	Histidine kinase
LPH46_03395	COG3437	response regulator, receiver
LPH46_03395	COG2205	protein histidine kinase activity
LPH46_03455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPH46_03505	COG2124	cytochrome p450
LPH46_03535	COG0305	Participates in initiation and elongation during chromosome replication
LPH46_03550	COG0667	Aldo Keto reductase
LPH46_03555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPH46_03590	COG2194	sulfuric ester hydrolase activity
LPH46_03595	COG2124	cytochrome p450
LPH46_03600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPH46_03610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH46_03620	COG0277	FAD linked oxidase domain protein
LPH46_03635	COG4206	TonB-dependent receptor
LPH46_03680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPH46_03685	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPH46_03710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPH46_03730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH46_03730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH46_03750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPH46_03755	COG0488	(ABC) transporter
LPH46_03765	COG3011	Protein conserved in bacteria
LPH46_03775	COG0564	pseudouridine synthase activity
LPH46_03780	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH46_03800	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_03805	COG2969	positive regulation of protein catabolic process
LPH46_03810	COG0625	glutathione transferase activity
LPH46_03830	COG0741	lytic transglycosylase activity
LPH46_03840	COG1702	phosphate starvation-inducible protein PhoH
LPH46_03855	COG4535	Mg2 and Co2 transporter CorC
LPH46_03890	COG3210	domain, Protein
LPH46_03895	COG2831	hemolysin activation secretion protein
LPH46_03920	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPH46_03940	COG3115	cell septum assembly
LPH46_03955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPH46_03965	COG0316	Belongs to the HesB IscA family
LPH46_03990	COG0167	dihydroorotate dehydrogenase activity
LPH46_03995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPH46_04000	COG0697	spore germination
LPH46_04005	COG0671	phosphoesterase, PA-phosphatase related
LPH46_04010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPH46_04020	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPH46_04025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPH46_04045	COG1132	(ABC) transporter
LPH46_04060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH46_04065	COG1538	Outer membrane efflux protein
LPH46_04070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPH46_04080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPH46_04095	COG4783	chaperone-mediated protein folding
LPH46_04105	COG0473	3-isopropylmalate dehydrogenase activity
LPH46_04115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPH46_04125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPH46_04135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPH46_04135	COG0316	Belongs to the HesB IscA family
LPH46_04140	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPH46_04155	COG0564	pseudouridine synthase activity
LPH46_04160	COG1530	ribonuclease E activity
LPH46_04180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH46_04195	COG0488	(ABC) transporter
LPH46_04205	COG1278	Cold shock
LPH46_04220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH46_04230	COG0049	tRNA binding
LPH46_04245	COG0085	RNA polymerase activity
LPH46_04250	COG0222	ribosome binding
LPH46_04265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPH46_04270	COG0250	Participates in transcription elongation, termination and antitermination
LPH46_04275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPH46_04285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH46_04305	COG0012	GTP binding
LPH46_04310	COG0193	aminoacyl-tRNA hydrolase activity
LPH46_04315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPH46_04320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPH46_04330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPH46_04335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPH46_04345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPH46_04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPH46_04430	COG0765	amino acid transport
LPH46_04435	COG1126	abc transporter atp-binding protein
LPH46_04440	COG0765	amino acid transport
LPH46_04445	COG1074	ATP-dependent DNA helicase activity
LPH46_04455	COG2095	MarC family integral membrane protein
LPH46_04460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH46_04490	COG2132	Multicopper oxidase
LPH46_04500	COG0210	DNA helicase
LPH46_04510	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPH46_04515	COG0616	signal peptide processing
LPH46_04535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPH46_04540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH46_04545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPH46_04555	COG2177	Part of the ABC transporter FtsEX involved in
LPH46_04560	COG2884	Cell division ATP-binding protein ftsE
LPH46_04565	COG0513	Belongs to the DEAD box helicase family
LPH46_04570	COG3118	belongs to the thioredoxin family
LPH46_04575	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPH46_04605	COG0793	Belongs to the peptidase S41A family
LPH46_04610	COG4942	peptidase
LPH46_04620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH46_04640	COG0493	'glutamate synthase
LPH46_04645	COG0067	glutamate synthase
LPH46_04645	COG0069	glutamate synthase activity
LPH46_04645	COG0070	glutamate synthase
LPH46_04745	COG3210	domain, Protein
LPH46_04885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH46_04895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH46_04900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH46_05010	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_05030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH46_05040	COG1199	ATP-dependent helicase activity
LPH46_05050	COG0288	reversible hydration of carbon dioxide
LPH46_05055	COG0438	transferase activity, transferring glycosyl groups
LPH46_05070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPH46_05075	COG2011	ABC-type metal ion transport system permease component
LPH46_05080	COG1464	Belongs to the NlpA lipoprotein family
LPH46_05095	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPH46_05100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPH46_05115	COG0626	cystathionine gamma-synthase activity
LPH46_05120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH46_05125	COG0739	heme binding
LPH46_05135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPH46_05140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH46_05165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPH46_05200	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH46_05215	COG3537	Alpha-1,2-mannosidase
LPH46_05235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPH46_05245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH46_05250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH46_05255	COG2207	Transcriptional regulator
LPH46_05260	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPH46_05290	COG3588	fructose-bisphosphate aldolase
LPH46_05305	COG0469	pyruvate kinase activity
LPH46_05325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH46_05330	COG0735	belongs to the Fur family
LPH46_05345	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH46_05345	COG5297	Belongs to the glycosyl hydrolase family 6
LPH46_05355	COG0612	Peptidase, M16
LPH46_05370	COG4305	rare lipoprotein A
LPH46_05375	COG0653	protein targeting
LPH46_05380	COG0739	heme binding
LPH46_05390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPH46_05405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPH46_05410	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPH46_05415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH46_05430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPH46_05435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPH46_05450	COG3116	cell division
LPH46_05455	COG0275	rRNA processing
LPH46_05465	COG0471	metal ion transport
LPH46_05465	COG3273	potassium ion transport
LPH46_05470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPH46_05515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH46_05540	COG0717	Belongs to the dCTP deaminase family
LPH46_05555	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPH46_05560	COG0802	atpase or kinase
LPH46_05565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPH46_05565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPH46_05570	COG1570	exodeoxyribonuclease VII activity
LPH46_05615	COG0776	regulation of translation
LPH46_05620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPH46_05620	COG0072	phenylalanine-tRNA ligase activity
LPH46_05625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPH46_05630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPH46_05640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPH46_05665	COG0745	RESPONSE REGULATOR receiver
LPH46_05680	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPH46_05730	COG0045	succinate-CoA ligase (ADP-forming) activity
LPH46_05735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPH46_05740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPH46_05755	COG0594	ribonuclease P activity
LPH46_05765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LPH46_05775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPH46_05780	COG0187	DNA topoisomerase II activity
LPH46_05790	COG0501	Belongs to the peptidase M48B family
LPH46_05835	COG0408	coproporphyrinogen oxidase activity
LPH46_05860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPH46_05930	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPH46_05940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPH46_05950	COG0511	ligase activity, forming carbon-carbon bonds
LPH46_05955	COG0439	Biotin carboxylase
LPH46_05960	COG0210	DNA helicase
LPH46_05995	COG1040	competence protein
LPH46_06000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPH46_06005	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPH46_06010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPH46_06025	COG2027	D-alanyl-D-alanine carboxypeptidase
LPH46_06060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH46_06070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPH46_06095	COG3121	Chaperone
LPH46_06100	COG3539	Fimbrial protein
LPH46_06105	COG1546	Belongs to the CinA family
LPH46_06110	COG0477	Major facilitator Superfamily
LPH46_06115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPH46_06120	COG1923	regulation of RNA biosynthetic process
LPH46_06130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPH46_06135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPH46_06145	COG1534	Rna-binding protein
LPH46_06160	COG0129	dihydroxy-acid dehydratase activity
LPH46_06190	COG1560	Kdo2-lipid A biosynthetic process
LPH46_06195	COG1519	Transferase
LPH46_06210	COG0228	four-way junction DNA binding
LPH46_06215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPH46_06220	COG0336	Belongs to the RNA methyltransferase TrmD family
LPH46_06225	COG0335	large ribosomal subunit rRNA binding
LPH46_06245	COG1393	Belongs to the ArsC family
LPH46_06255	COG0367	asparagine synthase
LPH46_06265	COG2070	2-Nitropropane dioxygenase
LPH46_06285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPH46_06300	COG0339	signal peptide processing
LPH46_06325	COG0525	valine-tRNA ligase activity
LPH46_06365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH46_06390	COG4221	oxidoreductase activity
LPH46_06400	COG0018	arginyl-trna synthetase
LPH46_06405	COG2003	Belongs to the UPF0758 family
LPH46_06410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPH46_06485	COG2223	nitrite transmembrane transporter activity
LPH46_06490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPH46_06495	COG0739	heme binding
LPH46_06500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPH46_06530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH46_06555	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_06565	COG1272	protein, Hemolysin III
LPH46_06570	COG0463	Glycosyl transferase, family 2
LPH46_06575	COG0084	hydrolase, TatD family'
LPH46_06590	COG0509	glycine decarboxylation via glycine cleavage system
LPH46_06595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPH46_06605	COG0330	HflC and HflK could
LPH46_06610	COG3956	TIGRFAM MazG family protein
LPH46_06615	COG1218	3'(2'),5'-bisphosphate nucleotidase
LPH46_06620	COG0494	nUDIX hydrolase
LPH46_06630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPH46_06640	COG0513	Belongs to the DEAD box helicase family
LPH46_06645	COG0720	synthase
LPH46_06670	COG1981	membrane
LPH46_06680	COG0587	DNA-directed DNA polymerase activity
LPH46_06690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPH46_06695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPH46_06710	COG0512	Glutamine amidotransferase of anthranilate synthase
LPH46_06715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPH46_06755	COG0006	proline dipeptidase activity
LPH46_06775	COG1862	Preprotein translocase
LPH46_06780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH46_06785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH46_06795	COG0617	tRNA 3'-terminal CCA addition
LPH46_06810	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPH46_06815	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPH46_06820	COG0166	Belongs to the GPI family
LPH46_06830	COG0779	Required for maturation of 30S ribosomal subunits
LPH46_06835	COG0195	Participates in both transcription termination and antitermination
LPH46_06840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPH46_06845	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPH46_06850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPH46_06860	COG1185	polyribonucleotide nucleotidyltransferase activity
LPH46_06865	COG1733	regulation of RNA biosynthetic process
LPH46_06870	COG0702	epimerase
LPH46_06885	COG0475	glutathione-regulated potassium exporter activity
LPH46_06915	COG2086	electron transfer activity
LPH46_06945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH46_07005	COG0477	Major facilitator Superfamily
LPH46_07030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH46_07035	COG0671	phosphoesterase, PA-phosphatase related
LPH46_07060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPH46_07070	COG0628	permease
LPH46_07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH46_07095	COG1090	epimerase
LPH46_07100	COG0318	PFAM AMP-dependent synthetase and ligase
LPH46_07120	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPH46_07135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH46_07140	COG0732	type I restriction modification DNA specificity domain
LPH46_07155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH46_07190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH46_07200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH46_07210	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPH46_07215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPH46_07220	COG1034	ATP synthesis coupled electron transport
LPH46_07255	COG1007	ATP synthesis coupled electron transport
LPH46_07260	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_07265	COG2851	Citrate transporter
LPH46_07280	COG0642	Histidine kinase
LPH46_07295	COG0784	Response regulator, receiver
LPH46_07295	COG2198	Histidine kinase
LPH46_07295	COG2205	protein histidine kinase activity
LPH46_07305	COG1301	dicarboxylic acid transport
LPH46_07310	COG0280	phosphate acetyltransferase
LPH46_07310	COG0281	malic enzyme
LPH46_07320	COG0742	ribosomal rna small subunit methyltransferase
LPH46_07335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPH46_07355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPH46_07360	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPH46_07395	COG2166	iron-sulfur cluster assembly
LPH46_07400	COG0215	cysteine-tRNA ligase activity
LPH46_07420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPH46_07440	COG0165	Argininosuccinate lyase
LPH46_07455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPH46_07490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH46_07550	COG5314	conjugation
LPH46_07575	COG1233	COG1233 Phytoene dehydrogenase and related
LPH46_07585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPH46_07600	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_07620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH46_07700	COG1914	H( )-stimulated, divalent metal cation uptake system
LPH46_07715	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPH46_07725	COG1946	Acyl-CoA thioesterase
LPH46_07805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPH46_07820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH46_07840	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPH46_07845	COG0575	Belongs to the CDS family
LPH46_07880	COG2833	Protein of unknown function (DUF455)
LPH46_07885	COG0528	UMP kinase activity
LPH46_07955	COG0800	Aldolase
LPH46_07965	COG0363	glucosamine-6-phosphate deaminase activity
LPH46_07970	COG0837	glucose binding
LPH46_07975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPH46_07980	COG3842	ATPase activity
LPH46_08000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPH46_08015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPH46_08025	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPH46_08030	COG1136	(ABC) transporter
LPH46_08035	COG2333	competence protein COMEC
LPH46_08035	COG0658	competence protein
LPH46_08055	COG1663	tetraacyldisaccharide 4'-kinase activity
LPH46_08060	COG0489	protein tyrosine kinase activity
LPH46_08065	COG2062	phosphohistidine phosphatase, SixA
LPH46_08075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH46_08120	COG0009	L-threonylcarbamoyladenylate synthase
LPH46_08125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPH46_08125	COG1754	DNA topoisomerase type I activity
LPH46_08135	COG2922	Belongs to the Smg family
LPH46_08140	COG0758	DNA mediated transformation
LPH46_08155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPH46_08165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LPH46_08230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPH46_08305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPH46_08310	COG0505	Belongs to the CarA family
LPH46_08315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPH46_08320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPH46_08330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPH46_08340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPH46_08355	COG1024	Enoyl-CoA hydratase
LPH46_08360	COG0527	aspartate kinase activity
LPH46_08370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPH46_08390	COG0494	nUDIX hydrolase
LPH46_08400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPH46_08425	COG0312	modulator of DNA gyrase
LPH46_08430	COG3028	Belongs to the UPF0307 family
LPH46_08435	COG0312	modulator of DNA gyrase
LPH46_08445	COG4804	nuclease activity
LPH46_08470	COG0583	DNA-binding transcription factor activity
LPH46_08485	COG1064	alcohol dehydrogenase
LPH46_08500	COG0667	Aldo Keto reductase
LPH46_08530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPH46_08560	COG0356	it plays a direct role in the translocation of protons across the membrane
LPH46_08585	COG0089	rRNA binding
LPH46_08595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPH46_08600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPH46_08605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPH46_08665	COG1841	ribosomal large subunit assembly
LPH46_08670	COG0200	Binds to the 23S rRNA
LPH46_08675	COG0201	protein transport
LPH46_08680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPH46_08685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPH46_08705	COG2960	long-chain fatty acid transporting porin activity
LPH46_08710	COG0606	chelatase, subunit chli
LPH46_08715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LPH46_08730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPH46_08745	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPH46_08750	COG0740	serine-type endopeptidase activity
LPH46_08755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPH46_08790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH46_08795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH46_08820	COG1187	pseudouridine synthase activity
LPH46_08825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPH46_08845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH46_08880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH46_08880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH46_08900	COG3772	lysozyme
LPH46_08940	COG0625	glutathione transferase activity
LPH46_08950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPH46_08955	COG1217	gtp-binding protein TYPA
LPH46_09000	COG0842	Transport permease protein
LPH46_09005	COG1131	(ABC) transporter
LPH46_09025	COG1643	Atp-dependent helicase
LPH46_09035	COG1956	GAF domain-containing protein
LPH46_09040	COG0729	surface antigen
LPH46_09045	COG2911	Protein conserved in bacteria
LPH46_09095	COG1937	Protein conserved in bacteria
LPH46_09130	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPH46_09135	COG0668	transmembrane transport
LPH46_09165	COG2733	membrane
LPH46_09180	COG2921	Belongs to the UPF0250 family
LPH46_09185	COG0321	lipoyl(octanoyl) transferase activity
LPH46_09190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPH46_09220	COG1253	flavin adenine dinucleotide binding
LPH46_09245	COG0504	CTP synthase activity
LPH46_09250	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPH46_09255	COG0148	phosphopyruvate hydratase activity
LPH46_09270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPH46_09275	COG2840	Smr protein MutS2
LPH46_09285	COG0644	oxidoreductase
LPH46_09285	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LPH46_09300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH46_09300	COG3218	ABC-type transport auxiliary lipoprotein component
LPH46_09305	COG1127	ABC transporter
LPH46_09310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH46_09375	COG1077	Cell shape determining protein MreB Mrl
LPH46_09385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPH46_09390	COG0768	penicillin binding
LPH46_09395	COG0772	Belongs to the SEDS family
LPH46_09405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH46_09425	COG2894	cell division
LPH46_09430	COG0850	regulation of cytokinetic process
LPH46_09450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPH46_09460	COG3038	cytochrome b561
LPH46_09465	COG2353	YceI-like domain
LPH46_09470	COG0784	Response regulator, receiver
LPH46_09470	COG5002	protein histidine kinase activity
LPH46_09480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPH46_09505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH46_09535	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPH46_09540	COG4208	sulfate ABC transporter
LPH46_09665	COG5532	Uncharacterized conserved protein (DUF2303)
LPH46_09690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH46_09715	COG1566	PFAM secretion protein HlyD family protein
LPH46_09720	COG2814	Major facilitator Superfamily
LPH46_09725	COG2267	carboxylic ester hydrolase activity
LPH46_09745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH46_09750	COG0617	tRNA 3'-terminal CCA addition
LPH46_09755	COG0741	lytic transglycosylase activity
LPH46_09830	COG1028	Short-chain dehydrogenase reductase Sdr
LPH46_09845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPH46_09850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPH46_09870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPH46_09875	COG0483	inositol monophosphate 1-phosphatase activity
LPH46_09885	COG1509	lysine 2,3-aminomutase activity
LPH46_09895	COG0402	S-adenosylhomocysteine deaminase activity
LPH46_09900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH46_09905	COG0546	phosphoglycolate phosphatase activity
LPH46_09915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH46_09950	COG0436	Aminotransferase
LPH46_09965	COG1187	pseudouridine synthase activity
LPH46_09970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPH46_09975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPH46_10010	COG0395	ABC-type sugar transport system, permease component
LPH46_10025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH46_10030	COG2957	Belongs to the agmatine deiminase family
LPH46_10055	COG0776	regulation of translation
LPH46_10065	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPH46_10080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPH46_10085	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPH46_10160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPH46_10170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPH46_10175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPH46_10180	COG0268	Binds directly to 16S ribosomal RNA
LPH46_10185	COG0728	peptidoglycan biosynthetic process
LPH46_10190	COG0196	riboflavin kinase activity
LPH46_10195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPH46_10220	COG1396	sequence-specific DNA binding
LPH46_10275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH46_10275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPH46_10350	COG0436	Aminotransferase
LPH46_10360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH46_10380	COG1902	pentaerythritol trinitrate reductase activity
LPH46_10390	COG1335	isochorismatase
LPH46_10400	COG1064	alcohol dehydrogenase
LPH46_10405	COG0604	alcohol dehydrogenase
LPH46_10430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH46_10435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH46_10465	COG0473	3-isopropylmalate dehydrogenase activity
LPH46_10495	COG0438	transferase activity, transferring glycosyl groups
LPH46_10505	COG2244	polysaccharide biosynthetic process
LPH46_10510	COG0438	transferase activity, transferring glycosyl groups
LPH46_10525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPH46_10530	COG2954	triphosphatase activity
LPH46_10535	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH46_10540	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPH46_10550	COG1278	Cold shock
LPH46_10575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH46_10585	COG0497	DNA recombination
LPH46_10600	COG0443	Heat shock 70 kDa protein
LPH46_10605	COG0484	heat shock protein binding
LPH46_10620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPH46_10630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPH46_10650	COG0745	RESPONSE REGULATOR receiver
LPH46_10655	COG2205	protein histidine kinase activity
LPH46_10665	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPH46_10670	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPH46_10690	COG2967	ApaG domain
LPH46_10700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH46_10705	COG0704	Plays a role in the regulation of phosphate uptake
LPH46_10715	COG0581	inorganic phosphate transmembrane transporter activity
LPH46_10720	COG0573	inorganic phosphate transmembrane transporter activity
LPH46_10725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPH46_10730	COG4651	solute:proton antiporter activity
LPH46_10730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPH46_10740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPH46_10750	COG0488	(ABC) transporter
LPH46_10775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPH46_10785	COG0489	protein tyrosine kinase activity
LPH46_10810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH46_10865	COG1469	GTP cyclohydrolase I activity
LPH46_10875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH46_10880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH46_10885	COG2902	Dehydrogenase
LPH46_10890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPH46_10920	COG2925	Exonuclease
LPH46_10940	COG0025	NhaP-type Na H and K H
LPH46_10960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPH46_10980	COG3079	Belongs to the UPF0149 family
LPH46_10985	COG0006	proline dipeptidase activity
LPH46_11025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPH46_11085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPH46_11110	COG3772	lysozyme
LPH46_11130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH46_11130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH46_11170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH46_11180	COG0328	RNA-DNA hybrid ribonuclease activity
LPH46_11185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH46_11205	COG0859	PFAM glycosyl transferase family 9
LPH46_11215	COG2943	transferase activity, transferring hexosyl groups
LPH46_11220	COG0400	carboxylic ester hydrolase activity
LPH46_11225	COG3275	phosphorelay sensor kinase activity
LPH46_11270	COG0463	Glycosyl transferase, family 2
LPH46_11280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPH46_11295	COG0392	lysyltransferase activity
LPH46_11295	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPH46_11300	COG0251	oxidation-reduction process
LPH46_11315	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPH46_11320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH46_11325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPH46_11330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPH46_11350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPH46_11400	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPH46_11510	COG0582	viral genome integration into host DNA
LPH46_11525	COG3772	lysozyme
LPH46_11580	COG0640	Transcriptional regulator
LPH46_11595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH46_11620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPH46_11655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPH46_11660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPH46_11670	COG0537	adenosine 5'-monophosphoramidase activity
LPH46_11690	COG0714	Associated with various cellular activities
LPH46_11700	COG1399	metal-binding, possibly nucleic acid-binding protein
LPH46_11705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPH46_11710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH46_11725	COG5297	Belongs to the glycosyl hydrolase family 6
LPH46_11730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPH46_11750	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPH46_11760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH46_11765	COG1764	response to oxidative stress
LPH46_11770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPH46_11775	COG2945	thiolester hydrolase activity
LPH46_11835	COG2353	YceI-like domain
LPH46_11840	COG1968	undecaprenyl-diphosphatase activity
LPH46_11845	COG0174	glutamine synthetase
LPH46_11850	COG0347	Belongs to the P(II) protein family
LPH46_11855	COG0004	ammonium transporteR
LPH46_11885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH46_11890	COG0084	hydrolase, TatD family'