locus-tag	class	description
LPH63_00010	COG0594	ribonuclease P activity
LPH63_00025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LPH63_00030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LPH63_00035	COG0045	succinate-CoA ligase (ADP-forming) activity
LPH63_00085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LPH63_00100	COG0745	RESPONSE REGULATOR receiver
LPH63_00125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LPH63_00135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LPH63_00140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LPH63_00145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LPH63_00145	COG0072	phenylalanine-tRNA ligase activity
LPH63_00150	COG0776	regulation of translation
LPH63_00195	COG1570	exodeoxyribonuclease VII activity
LPH63_00200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LPH63_00200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LPH63_00205	COG0802	atpase or kinase
LPH63_00210	COG0860	N-Acetylmuramoyl-L-alanine amidase
LPH63_00225	COG0717	Belongs to the dCTP deaminase family
LPH63_00250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH63_00295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LPH63_00300	COG3273	potassium ion transport
LPH63_00300	COG0471	metal ion transport
LPH63_00310	COG0275	rRNA processing
LPH63_00315	COG3116	cell division
LPH63_00330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LPH63_00335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LPH63_00350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH63_00355	COG1181	Belongs to the D-alanine--D-alanine ligase family
LPH63_00360	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LPH63_00375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LPH63_00385	COG0739	heme binding
LPH63_00390	COG0653	protein targeting
LPH63_00395	COG4305	rare lipoprotein A
LPH63_00410	COG0612	Peptidase, M16
LPH63_00420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH63_00420	COG5297	Belongs to the glycosyl hydrolase family 6
LPH63_00435	COG0735	belongs to the Fur family
LPH63_00440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH63_00460	COG0469	pyruvate kinase activity
LPH63_00475	COG3588	fructose-bisphosphate aldolase
LPH63_00505	COG2249	NAD(P)H dehydrogenase (quinone) activity
LPH63_00510	COG2207	Transcriptional regulator
LPH63_00515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH63_00520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LPH63_00530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LPH63_00550	COG3537	Alpha-1,2-mannosidase
LPH63_00565	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH63_00575	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LPH63_00600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LPH63_00625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH63_00630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LPH63_00635	COG0739	heme binding
LPH63_00640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH63_00645	COG0626	cystathionine gamma-synthase activity
LPH63_00660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LPH63_00665	COG0508	dehydrogenase complex catalyzes the overall conversion of
LPH63_00680	COG1464	Belongs to the NlpA lipoprotein family
LPH63_00685	COG2011	ABC-type metal ion transport system permease component
LPH63_00690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LPH63_00705	COG0438	transferase activity, transferring glycosyl groups
LPH63_00710	COG0288	reversible hydration of carbon dioxide
LPH63_00720	COG1199	ATP-dependent helicase activity
LPH63_00730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH63_00750	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_00865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH63_00870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH63_00880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH63_01015	COG3210	domain, Protein
LPH63_01115	COG0067	glutamate synthase
LPH63_01115	COG0069	glutamate synthase activity
LPH63_01115	COG0070	glutamate synthase
LPH63_01120	COG0493	'glutamate synthase
LPH63_01140	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LPH63_01150	COG4942	peptidase
LPH63_01155	COG0793	Belongs to the peptidase S41A family
LPH63_01180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LPH63_01185	COG3118	belongs to the thioredoxin family
LPH63_01190	COG0513	Belongs to the DEAD box helicase family
LPH63_01195	COG2884	Cell division ATP-binding protein ftsE
LPH63_01200	COG2177	Part of the ABC transporter FtsEX involved in
LPH63_01210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LPH63_01215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH63_01220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LPH63_01240	COG0616	signal peptide processing
LPH63_01245	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LPH63_01255	COG0210	DNA helicase
LPH63_01265	COG2132	Multicopper oxidase
LPH63_01295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH63_01300	COG2095	MarC family integral membrane protein
LPH63_01310	COG1074	ATP-dependent DNA helicase activity
LPH63_01315	COG0765	amino acid transport
LPH63_01320	COG1126	abc transporter atp-binding protein
LPH63_01325	COG0765	amino acid transport
LPH63_01330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LPH63_01405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LPH63_01415	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LPH63_01420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LPH63_01430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LPH63_01435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LPH63_01440	COG0193	aminoacyl-tRNA hydrolase activity
LPH63_01445	COG0012	GTP binding
LPH63_01465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH63_01475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LPH63_01480	COG0250	Participates in transcription elongation, termination and antitermination
LPH63_01485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LPH63_01500	COG0222	ribosome binding
LPH63_01505	COG0085	RNA polymerase activity
LPH63_01520	COG0049	tRNA binding
LPH63_01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LPH63_01545	COG1278	Cold shock
LPH63_01555	COG0488	(ABC) transporter
LPH63_01570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH63_01590	COG1530	ribonuclease E activity
LPH63_01595	COG0564	pseudouridine synthase activity
LPH63_01610	COG2154	pterin-4-alpha-carbinolamine dehydratase
LPH63_01615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LPH63_01615	COG0316	Belongs to the HesB IscA family
LPH63_01625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LPH63_01635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LPH63_01645	COG0473	3-isopropylmalate dehydrogenase activity
LPH63_01655	COG4783	chaperone-mediated protein folding
LPH63_01670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LPH63_01680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LPH63_01685	COG1538	Outer membrane efflux protein
LPH63_01690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LPH63_01705	COG1132	(ABC) transporter
LPH63_01725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LPH63_01730	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LPH63_01740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LPH63_01745	COG0671	phosphoesterase, PA-phosphatase related
LPH63_01750	COG0697	spore germination
LPH63_01755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LPH63_01760	COG0167	dihydroorotate dehydrogenase activity
LPH63_01790	COG0316	Belongs to the HesB IscA family
LPH63_01800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LPH63_01815	COG3115	cell septum assembly
LPH63_01835	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LPH63_01860	COG2831	hemolysin activation secretion protein
LPH63_01865	COG3210	domain, Protein
LPH63_01900	COG4535	Mg2 and Co2 transporter CorC
LPH63_01915	COG1702	phosphate starvation-inducible protein PhoH
LPH63_01925	COG0741	lytic transglycosylase activity
LPH63_01945	COG0625	glutathione transferase activity
LPH63_01950	COG2969	positive regulation of protein catabolic process
LPH63_01955	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_01975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH63_01980	COG0564	pseudouridine synthase activity
LPH63_01990	COG3011	Protein conserved in bacteria
LPH63_02000	COG0488	(ABC) transporter
LPH63_02005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LPH63_02025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH63_02025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LPH63_02045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LPH63_02070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LPH63_02075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LPH63_02120	COG4206	TonB-dependent receptor
LPH63_02135	COG0277	FAD linked oxidase domain protein
LPH63_02145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH63_02155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LPH63_02160	COG2124	cytochrome p450
LPH63_02165	COG2194	sulfuric ester hydrolase activity
LPH63_02200	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LPH63_02205	COG0667	Aldo Keto reductase
LPH63_02220	COG0305	Participates in initiation and elongation during chromosome replication
LPH63_02250	COG2124	cytochrome p450
LPH63_02300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LPH63_02360	COG2205	protein histidine kinase activity
LPH63_02360	COG4999	Histidine kinase
LPH63_02360	COG3850	Histidine kinase
LPH63_02360	COG3437	response regulator, receiver
LPH63_02400	COG0861	Integral membrane protein TerC family
LPH63_02405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LPH63_02415	COG0531	amino acid
LPH63_02430	COG1116	anion transmembrane transporter activity
LPH63_02440	COG2853	Lipoprotein
LPH63_02455	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH63_02460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH63_02465	COG1127	ABC transporter
LPH63_02470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LPH63_02475	COG1074	ATP-dependent DNA helicase activity
LPH63_02485	COG0180	Tryptophanyl-tRNA synthetase
LPH63_02495	COG0358	DNA primase activity
LPH63_02500	COG1295	ribonuclease BN
LPH63_02505	COG1610	YqeY-like protein
LPH63_02520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LPH63_02525	COG0668	transmembrane transport
LPH63_02545	COG0456	acetyltransferase
LPH63_02555	COG1183	phosphatidylcholine synthase activity
LPH63_02585	COG0604	alcohol dehydrogenase
LPH63_02590	COG0330	HflC and HflK could
LPH63_02595	COG0330	HflC and HflK could
LPH63_02610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LPH63_02640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH63_02645	COG1160	GTP binding
LPH63_02650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LPH63_02660	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LPH63_02665	COG1611	Belongs to the LOG family
LPH63_02760	COG2878	Part of a membrane complex involved in electron transport
LPH63_02785	COG3107	peptidoglycan biosynthetic process
LPH63_02795	COG1162	GTPase activity
LPH63_02800	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LPH63_02805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LPH63_02805	COG0519	Catalyzes the synthesis of GMP from XMP
LPH63_02825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LPH63_02855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH63_02860	COG3590	peptidase
LPH63_02880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LPH63_02885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LPH63_02895	COG0628	permease
LPH63_02905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LPH63_02915	COG1555	photosystem II stabilization
LPH63_02920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LPH63_02925	COG1477	protein flavinylation
LPH63_02950	COG4774	siderophore transport
LPH63_02970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LPH63_02985	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LPH63_02990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH63_02995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH63_03030	COG1324	tolerance protein
LPH63_03055	COG0351	phosphomethylpyrimidine kinase
LPH63_03055	COG0352	thiamine-phosphate diphosphorylase activity
LPH63_03060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LPH63_03080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LPH63_03090	COG0494	nUDIX hydrolase
LPH63_03095	COG0545	Peptidyl-prolyl cis-trans isomerase
LPH63_03110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LPH63_03135	COG2311	Membrane
LPH63_03145	COG0791	NLP P60 protein
LPH63_03150	COG0791	NLP P60 protein
LPH63_03155	COG1301	dicarboxylic acid transport
LPH63_03165	COG0037	tRNA processing
LPH63_03170	COG1722	exodeoxyribonuclease VII activity
LPH63_03175	COG0142	geranyltranstransferase activity
LPH63_03250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LPH63_03290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LPH63_03310	COG0514	ATP-dependent DNA helicase (RecQ)
LPH63_03315	COG0783	Belongs to the Dps family
LPH63_03320	COG1643	Atp-dependent helicase
LPH63_03330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH63_03330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LPH63_03335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LPH63_03340	COG1845	cytochrome c oxidase, subunit III
LPH63_03345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LPH63_03355	COG0142	geranyltranstransferase activity
LPH63_03375	COG1595	DNA-templated transcription, initiation
LPH63_03400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH63_03415	COG2239	Acts as a magnesium transporter
LPH63_03420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LPH63_03425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LPH63_03435	COG1660	Displays ATPase and GTPase activities
LPH63_03455	COG1137	ATPase activity
LPH63_03470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LPH63_03485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LPH63_03495	COG0047	phosphoribosylformylglycinamidine synthase activity
LPH63_03495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LPH63_03500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LPH63_03510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LPH63_03555	COG2915	High frequency lysogenization protein hflD homolog
LPH63_03575	COG0542	response to heat
LPH63_03580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LPH63_03585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LPH63_03595	COG0492	ferredoxin-NADP+ reductase activity
LPH63_03600	COG1674	ftsk spoiiie
LPH63_03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LPH63_03620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LPH63_03635	COG4191	Histidine kinase
LPH63_03660	COG0837	glucose binding
LPH63_03680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH63_03685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LPH63_03705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LPH63_03710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH63_03715	COG0726	polysaccharide deacetylase
LPH63_03720	COG0297	glycogen (starch) synthase activity
LPH63_03725	COG2146	nitrite reductase [NAD(P)H] activity
LPH63_03730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LPH63_03735	COG0719	Fe-S assembly protein
LPH63_03740	COG0396	ATPase activity
LPH63_03745	COG0719	Fe-S assembly protein
LPH63_03750	COG1959	2 iron, 2 sulfur cluster binding
LPH63_03805	COG2226	methyltransferase
LPH63_03810	COG0308	aminopeptidase N
LPH63_03870	COG0175	sulfate reduction
LPH63_03885	COG0175	sulfate reduction
LPH63_03890	COG2895	sulfate adenylyltransferase (ATP) activity
LPH63_03890	COG0529	Catalyzes the synthesis of activated sulfate
LPH63_03895	COG1758	RNA polymerase activity
LPH63_03900	COG0194	GDP metabolic process
LPH63_03905	COG1561	YicC-like family, N-terminal region
LPH63_03920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LPH63_03965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LPH63_03970	COG1459	type II secretion system
LPH63_03975	COG2165	general secretion pathway protein
LPH63_03980	COG4970	Tfp pilus assembly protein FimT
LPH63_03985	COG2165	general secretion pathway protein
LPH63_03990	COG4795	General secretion pathway protein
LPH63_03995	COG3156	type II secretion system protein K
LPH63_04005	COG3156	type II secretion system protein K
LPH63_04010	COG3166	PFAM Fimbrial assembly family protein
LPH63_04025	COG1450	Type ii and iii secretion system protein
LPH63_04030	COG5295	Hep Hag repeat protein
LPH63_04040	COG3634	alkyl hydroperoxide reductase activity
LPH63_04045	COG0583	DNA-binding transcription factor activity
LPH63_04075	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LPH63_04100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LPH63_04120	COG0567	Dehydrogenase, E1 component
LPH63_04125	COG2850	peptidyl-arginine hydroxylation
LPH63_04150	COG1131	(ABC) transporter
LPH63_04160	COG0386	Belongs to the glutathione peroxidase family
LPH63_04175	COG2900	Belongs to the SlyX family
LPH63_04190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LPH63_04200	COG2226	methyltransferase
LPH63_04205	COG1309	transcriptional regulator
LPH63_04235	COG4555	ABC transporter
LPH63_04240	COG1668	transmembrane transport
LPH63_04255	COG0077	Prephenate dehydratase
LPH63_04255	COG1605	Chorismate mutase
LPH63_04270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LPH63_04285	COG1192	Involved in chromosome partitioning
LPH63_04290	COG1475	DNA binding
LPH63_04300	COG0463	Glycosyl transferase, family 2
LPH63_04310	COG0318	PFAM AMP-dependent synthetase and ligase
LPH63_04320	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LPH63_04355	COG1297	OPT oligopeptide transporter protein
LPH63_04360	COG0823	Involved in the tonB-independent uptake of proteins
LPH63_04360	COG1506	peptidase
LPH63_04365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH63_04380	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_04390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LPH63_04400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LPH63_04415	COG1381	Involved in DNA repair and RecF pathway recombination
LPH63_04420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LPH63_04445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH63_04480	COG4953	penicillin-binding protein 1C
LPH63_04495	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LPH63_04500	COG1686	Belongs to the peptidase S11 family
LPH63_04515	COG0540	Belongs to the ATCase OTCase family
LPH63_04525	COG0527	aspartate kinase activity
LPH63_04525	COG0460	homoserine dehydrogenase
LPH63_04530	COG0083	homoserine kinase activity
LPH63_04535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LPH63_04560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LPH63_04565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LPH63_04575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LPH63_04575	COG0131	Imidazoleglycerol-phosphate dehydratase
LPH63_04620	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LPH63_04625	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LPH63_04630	COG0235	Class ii aldolase
LPH63_04635	COG0531	amino acid
LPH63_04640	COG0531	amino acid
LPH63_04645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LPH63_04650	COG0277	FAD linked oxidase domain protein
LPH63_04655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LPH63_04675	COG1280	lysine exporter protein (LysE YggA)
LPH63_04690	COG3210	domain, Protein
LPH63_04790	COG3210	domain, Protein
LPH63_04935	COG2951	lytic endotransglycosylase activity
LPH63_04965	COG0495	leucyl-tRNA aminoacylation
LPH63_04975	COG3118	belongs to the thioredoxin family
LPH63_04980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LPH63_04985	COG1881	PFAM PEBP family protein
LPH63_05085	COG3772	lysozyme
LPH63_05095	COG0557	exoribonuclease II activity
LPH63_05105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LPH63_05115	COG0302	gtp cyclohydrolase
LPH63_05125	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LPH63_05135	COG1289	transmembrane transporter activity
LPH63_05155	COG0151	Belongs to the GarS family
LPH63_05160	COG0138	bifunctional purine biosynthesis protein purh
LPH63_05170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LPH63_05180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH63_05190	COG0596	Alpha beta hydrolase
LPH63_05200	COG0727	PFAM Uncharacterised protein family (UPF0153)
LPH63_05225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH63_05225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LPH63_05235	COG0751	glycine-tRNA ligase activity
LPH63_05265	COG0840	transmembrane signaling receptor activity
LPH63_05270	COG0643	Histidine kinase
LPH63_05270	COG2198	Histidine kinase
LPH63_05270	COG0784	Response regulator, receiver
LPH63_05275	COG2201	protein-glutamate methylesterase activity
LPH63_05300	COG0285	dihydrofolate synthase activity
LPH63_05310	COG0339	signal peptide processing
LPH63_05335	COG1301	dicarboxylic acid transport
LPH63_05340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LPH63_05350	COG2091	lysine biosynthetic process via aminoadipic acid
LPH63_05390	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LPH63_05450	COG2337	Toxic component of a toxin-antitoxin (TA) module
LPH63_05460	COG0582	viral genome integration into host DNA
LPH63_05525	COG3077	Addiction module antitoxin, RelB DinJ family
LPH63_05530	COG3041	Addiction module toxin RelE StbE family
LPH63_05605	COG1487	ribonuclease activity
LPH63_05630	COG0552	protein localization to endoplasmic reticulum
LPH63_05650	COG0217	transcriptional regulatory protein
LPH63_05665	COG3158	transport of potassium into the cell
LPH63_05675	COG0824	Thioesterase
LPH63_05680	COG0811	peptide transport
LPH63_05685	COG0848	biopolymer transport protein
LPH63_05700	COG2885	chlorophyll binding
LPH63_05710	COG0602	queuosine metabolic process
LPH63_05720	COG1515	deoxyribonuclease V activity
LPH63_05730	COG0386	Belongs to the glutathione peroxidase family
LPH63_05740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LPH63_05750	COG0406	alpha-ribazole phosphatase activity
LPH63_05770	COG0084	hydrolase, TatD family'
LPH63_05775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LPH63_05805	COG0004	ammonium transporteR
LPH63_05810	COG0347	Belongs to the P(II) protein family
LPH63_05815	COG0174	glutamine synthetase
LPH63_05820	COG1968	undecaprenyl-diphosphatase activity
LPH63_05825	COG2353	YceI-like domain
LPH63_05885	COG2945	thiolester hydrolase activity
LPH63_05890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LPH63_05895	COG1764	response to oxidative stress
LPH63_05900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LPH63_05910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LPH63_05930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LPH63_05935	COG5297	Belongs to the glycosyl hydrolase family 6
LPH63_05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LPH63_05955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LPH63_05960	COG1399	metal-binding, possibly nucleic acid-binding protein
LPH63_05970	COG0714	Associated with various cellular activities
LPH63_05990	COG0537	adenosine 5'-monophosphoramidase activity
LPH63_06000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LPH63_06005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LPH63_06040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LPH63_06065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH63_06080	COG0640	Transcriptional regulator
LPH63_06135	COG3772	lysozyme
LPH63_06150	COG0582	viral genome integration into host DNA
LPH63_06260	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LPH63_06310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LPH63_06330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LPH63_06335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LPH63_06340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LPH63_06345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LPH63_06360	COG0251	oxidation-reduction process
LPH63_06365	COG0392	lysyltransferase activity
LPH63_06365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LPH63_06380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LPH63_06390	COG0463	Glycosyl transferase, family 2
LPH63_06440	COG3275	phosphorelay sensor kinase activity
LPH63_06445	COG0400	carboxylic ester hydrolase activity
LPH63_06450	COG2943	transferase activity, transferring hexosyl groups
LPH63_06460	COG0859	PFAM glycosyl transferase family 9
LPH63_06480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH63_06485	COG0328	RNA-DNA hybrid ribonuclease activity
LPH63_06495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH63_06535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH63_06535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH63_06555	COG3772	lysozyme
LPH63_06580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LPH63_06640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LPH63_06680	COG0006	proline dipeptidase activity
LPH63_06685	COG3079	Belongs to the UPF0149 family
LPH63_06705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LPH63_06725	COG0025	NhaP-type Na H and K H
LPH63_06740	COG2925	Exonuclease
LPH63_06770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LPH63_06775	COG2902	Dehydrogenase
LPH63_06780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH63_06785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH63_06795	COG1469	GTP cyclohydrolase I activity
LPH63_06850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH63_06875	COG0489	protein tyrosine kinase activity
LPH63_06885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LPH63_06910	COG0488	(ABC) transporter
LPH63_06930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LPH63_06940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LPH63_06940	COG4651	solute:proton antiporter activity
LPH63_06945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LPH63_06950	COG0573	inorganic phosphate transmembrane transporter activity
LPH63_06955	COG0581	inorganic phosphate transmembrane transporter activity
LPH63_06965	COG0704	Plays a role in the regulation of phosphate uptake
LPH63_06970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LPH63_06980	COG2967	ApaG domain
LPH63_07000	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LPH63_07005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LPH63_07015	COG2205	protein histidine kinase activity
LPH63_07020	COG0745	RESPONSE REGULATOR receiver
LPH63_07040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LPH63_07050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LPH63_07065	COG0484	heat shock protein binding
LPH63_07070	COG0443	Heat shock 70 kDa protein
LPH63_07085	COG0497	DNA recombination
LPH63_07095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LPH63_07120	COG1278	Cold shock
LPH63_07130	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LPH63_07135	COG1472	Belongs to the glycosyl hydrolase 3 family
LPH63_07140	COG2954	triphosphatase activity
LPH63_07145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LPH63_07160	COG0438	transferase activity, transferring glycosyl groups
LPH63_07165	COG2244	polysaccharide biosynthetic process
LPH63_07175	COG0438	transferase activity, transferring glycosyl groups
LPH63_07205	COG0473	3-isopropylmalate dehydrogenase activity
LPH63_07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LPH63_07240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LPH63_07265	COG0604	alcohol dehydrogenase
LPH63_07270	COG1064	alcohol dehydrogenase
LPH63_07280	COG1335	isochorismatase
LPH63_07290	COG1902	pentaerythritol trinitrate reductase activity
LPH63_07310	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LPH63_07320	COG0436	Aminotransferase
LPH63_07395	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
LPH63_07395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH63_07455	COG1396	sequence-specific DNA binding
LPH63_07480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LPH63_07485	COG0196	riboflavin kinase activity
LPH63_07490	COG0728	peptidoglycan biosynthetic process
LPH63_07495	COG0268	Binds directly to 16S ribosomal RNA
LPH63_07500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LPH63_07505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LPH63_07515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LPH63_07590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LPH63_07595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LPH63_07610	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LPH63_07620	COG0776	regulation of translation
LPH63_07645	COG2957	Belongs to the agmatine deiminase family
LPH63_07650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LPH63_07665	COG0395	ABC-type sugar transport system, permease component
LPH63_07700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LPH63_07705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LPH63_07710	COG1187	pseudouridine synthase activity
LPH63_07725	COG0436	Aminotransferase
LPH63_07760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LPH63_07775	COG0546	phosphoglycolate phosphatase activity
LPH63_07780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LPH63_07785	COG0402	S-adenosylhomocysteine deaminase activity
LPH63_07795	COG1509	lysine 2,3-aminomutase activity
LPH63_07805	COG0483	inositol monophosphate 1-phosphatase activity
LPH63_07810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LPH63_07830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPH63_07835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LPH63_07850	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_07925	COG0741	lytic transglycosylase activity
LPH63_07930	COG0617	tRNA 3'-terminal CCA addition
LPH63_07935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LPH63_07955	COG2267	carboxylic ester hydrolase activity
LPH63_07960	COG2814	Major facilitator Superfamily
LPH63_07965	COG1566	PFAM secretion protein HlyD family protein
LPH63_07990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LPH63_08015	COG5532	Uncharacterized conserved protein (DUF2303)
LPH63_08135	COG4208	sulfate ABC transporter
LPH63_08140	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LPH63_08170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LPH63_08195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LPH63_08205	COG5002	protein histidine kinase activity
LPH63_08205	COG0784	Response regulator, receiver
LPH63_08210	COG2353	YceI-like domain
LPH63_08215	COG3038	cytochrome b561
LPH63_08225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LPH63_08245	COG0850	regulation of cytokinetic process
LPH63_08250	COG2894	cell division
LPH63_08270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LPH63_08280	COG0772	Belongs to the SEDS family
LPH63_08285	COG0768	penicillin binding
LPH63_08290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LPH63_08300	COG1077	Cell shape determining protein MreB Mrl
LPH63_08365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LPH63_08370	COG1127	ABC transporter
LPH63_08375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LPH63_08375	COG3218	ABC-type transport auxiliary lipoprotein component
LPH63_08390	COG0644	oxidoreductase
LPH63_08390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LPH63_08400	COG2840	Smr protein MutS2
LPH63_08405	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LPH63_08420	COG0148	phosphopyruvate hydratase activity
LPH63_08425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LPH63_08430	COG0504	CTP synthase activity
LPH63_08455	COG1253	flavin adenine dinucleotide binding
LPH63_08485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LPH63_08490	COG0321	lipoyl(octanoyl) transferase activity
LPH63_08495	COG2921	Belongs to the UPF0250 family
LPH63_08510	COG2733	membrane
LPH63_08540	COG0668	transmembrane transport
LPH63_08545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LPH63_08580	COG1937	Protein conserved in bacteria
LPH63_08630	COG2911	Protein conserved in bacteria
LPH63_08635	COG0729	surface antigen
LPH63_08640	COG1956	GAF domain-containing protein
LPH63_08650	COG1643	Atp-dependent helicase
LPH63_08670	COG1131	(ABC) transporter
LPH63_08675	COG0842	Transport permease protein
LPH63_08720	COG1217	gtp-binding protein TYPA
LPH63_08725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LPH63_08735	COG0625	glutathione transferase activity
LPH63_08775	COG3772	lysozyme
LPH63_08795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH63_08795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LPH63_08830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH63_08850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LPH63_08855	COG1187	pseudouridine synthase activity
LPH63_08880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH63_08885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LPH63_08920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LPH63_08925	COG0740	serine-type endopeptidase activity
LPH63_08930	COG0544	peptidyl-prolyl cis-trans isomerase activity
LPH63_08945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LPH63_08960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LPH63_08965	COG0606	chelatase, subunit chli
LPH63_08970	COG2960	long-chain fatty acid transporting porin activity
LPH63_08990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LPH63_08995	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LPH63_09000	COG0201	protein transport
LPH63_09005	COG0200	Binds to the 23S rRNA
LPH63_09010	COG1841	ribosomal large subunit assembly
LPH63_09070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LPH63_09075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LPH63_09080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LPH63_09090	COG0089	rRNA binding
LPH63_09115	COG0356	it plays a direct role in the translocation of protons across the membrane
LPH63_09145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LPH63_09175	COG0667	Aldo Keto reductase
LPH63_09190	COG1064	alcohol dehydrogenase
LPH63_09205	COG0583	DNA-binding transcription factor activity
LPH63_09230	COG4804	nuclease activity
LPH63_09240	COG0312	modulator of DNA gyrase
LPH63_09245	COG3028	Belongs to the UPF0307 family
LPH63_09250	COG0312	modulator of DNA gyrase
LPH63_09275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LPH63_09285	COG0494	nUDIX hydrolase
LPH63_09305	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LPH63_09315	COG0527	aspartate kinase activity
LPH63_09320	COG1024	Enoyl-CoA hydratase
LPH63_09335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LPH63_09345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LPH63_09355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LPH63_09360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LPH63_09365	COG0505	Belongs to the CarA family
LPH63_09370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LPH63_09445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LPH63_09510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LPH63_09520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LPH63_09535	COG0758	DNA mediated transformation
LPH63_09540	COG2922	Belongs to the Smg family
LPH63_09550	COG1754	DNA topoisomerase type I activity
LPH63_09550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LPH63_09555	COG0009	L-threonylcarbamoyladenylate synthase
LPH63_09600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LPH63_09610	COG2062	phosphohistidine phosphatase, SixA
LPH63_09615	COG0489	protein tyrosine kinase activity
LPH63_09620	COG1663	tetraacyldisaccharide 4'-kinase activity
LPH63_09640	COG2333	competence protein COMEC
LPH63_09640	COG0658	competence protein
LPH63_09645	COG1136	(ABC) transporter
LPH63_09650	COG4591	ABC-type transport system involved in lipoprotein release permease component
LPH63_09660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LPH63_09675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LPH63_09695	COG3842	ATPase activity
LPH63_09700	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LPH63_09705	COG0837	glucose binding
LPH63_09710	COG0363	glucosamine-6-phosphate deaminase activity
LPH63_09720	COG0800	Aldolase
LPH63_09790	COG0528	UMP kinase activity
LPH63_09795	COG2833	Protein of unknown function (DUF455)
LPH63_09830	COG0575	Belongs to the CDS family
LPH63_09835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LPH63_09855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LPH63_09870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LPH63_09950	COG1946	Acyl-CoA thioesterase
LPH63_09960	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LPH63_09975	COG1914	H( )-stimulated, divalent metal cation uptake system
LPH63_10055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH63_10075	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_10090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LPH63_10100	COG1233	COG1233 Phytoene dehydrogenase and related
LPH63_10125	COG5314	conjugation
LPH63_10190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LPH63_10225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LPH63_10240	COG0165	Argininosuccinate lyase
LPH63_10260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LPH63_10280	COG0215	cysteine-tRNA ligase activity
LPH63_10285	COG2166	iron-sulfur cluster assembly
LPH63_10315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LPH63_10320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LPH63_10340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LPH63_10355	COG0742	ribosomal rna small subunit methyltransferase
LPH63_10365	COG0280	phosphate acetyltransferase
LPH63_10365	COG0281	malic enzyme
LPH63_10370	COG1301	dicarboxylic acid transport
LPH63_10380	COG2205	protein histidine kinase activity
LPH63_10380	COG2198	Histidine kinase
LPH63_10380	COG0784	Response regulator, receiver
LPH63_10395	COG0642	Histidine kinase
LPH63_10410	COG2851	Citrate transporter
LPH63_10415	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_10420	COG1007	ATP synthesis coupled electron transport
LPH63_10455	COG1034	ATP synthesis coupled electron transport
LPH63_10460	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LPH63_10465	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LPH63_10475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH63_10485	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LPH63_10520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LPH63_10535	COG0732	type I restriction modification DNA specificity domain
LPH63_10540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LPH63_10555	COG1049	propionate catabolic process, 2-methylcitrate cycle
LPH63_10575	COG0318	PFAM AMP-dependent synthetase and ligase
LPH63_10580	COG1090	epimerase
LPH63_10585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LPH63_10605	COG0628	permease
LPH63_10615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LPH63_10645	COG0671	phosphoesterase, PA-phosphatase related
LPH63_10650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LPH63_10675	COG0477	Major facilitator Superfamily
LPH63_10730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LPH63_10760	COG2086	electron transfer activity
LPH63_10790	COG0475	glutathione-regulated potassium exporter activity
LPH63_10805	COG0702	epimerase
LPH63_10810	COG1733	regulation of RNA biosynthetic process
LPH63_10815	COG1185	polyribonucleotide nucleotidyltransferase activity
LPH63_10825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LPH63_10830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LPH63_10835	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LPH63_10840	COG0195	Participates in both transcription termination and antitermination
LPH63_10845	COG0779	Required for maturation of 30S ribosomal subunits
LPH63_10855	COG0166	Belongs to the GPI family
LPH63_10860	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LPH63_10865	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LPH63_10880	COG0617	tRNA 3'-terminal CCA addition
LPH63_10890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH63_10895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LPH63_10900	COG1862	Preprotein translocase
LPH63_10920	COG0006	proline dipeptidase activity
LPH63_10960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LPH63_10965	COG0512	Glutamine amidotransferase of anthranilate synthase
LPH63_10980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LPH63_10985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LPH63_10995	COG0587	DNA-directed DNA polymerase activity
LPH63_11005	COG1981	membrane
LPH63_11030	COG0720	synthase
LPH63_11035	COG0513	Belongs to the DEAD box helicase family
LPH63_11045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LPH63_11055	COG0494	nUDIX hydrolase
LPH63_11060	COG1218	3'(2'),5'-bisphosphate nucleotidase
LPH63_11065	COG3956	TIGRFAM MazG family protein
LPH63_11070	COG0330	HflC and HflK could
LPH63_11080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LPH63_11085	COG0509	glycine decarboxylation via glycine cleavage system
LPH63_11100	COG0084	hydrolase, TatD family'
LPH63_11105	COG0463	Glycosyl transferase, family 2
LPH63_11110	COG1272	protein, Hemolysin III
LPH63_11120	COG1028	Short-chain dehydrogenase reductase Sdr
LPH63_11140	COG4137	Cytochrome C assembly protein
LPH63_11145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH63_11175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LPH63_11180	COG0739	heme binding
LPH63_11185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LPH63_11190	COG2223	nitrite transmembrane transporter activity
LPH63_11255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LPH63_11260	COG2003	Belongs to the UPF0758 family
LPH63_11265	COG0018	arginyl-trna synthetase
LPH63_11275	COG4221	oxidoreductase activity
LPH63_11300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LPH63_11340	COG0525	valine-tRNA ligase activity
LPH63_11365	COG0339	signal peptide processing
LPH63_11380	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LPH63_11400	COG2070	2-Nitropropane dioxygenase
LPH63_11410	COG0367	asparagine synthase
LPH63_11420	COG1393	Belongs to the ArsC family
LPH63_11440	COG0335	large ribosomal subunit rRNA binding
LPH63_11445	COG0336	Belongs to the RNA methyltransferase TrmD family
LPH63_11450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LPH63_11455	COG0228	four-way junction DNA binding
LPH63_11470	COG1519	Transferase
LPH63_11475	COG1560	Kdo2-lipid A biosynthetic process
LPH63_11505	COG0129	dihydroxy-acid dehydratase activity
LPH63_11520	COG1534	Rna-binding protein
LPH63_11530	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LPH63_11535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LPH63_11545	COG1923	regulation of RNA biosynthetic process
LPH63_11550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LPH63_11555	COG0477	Major facilitator Superfamily
LPH63_11560	COG1546	Belongs to the CinA family
LPH63_11565	COG3539	Fimbrial protein
LPH63_11570	COG3121	Chaperone
LPH63_11595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LPH63_11600	COG4137	Cytochrome C assembly protein
LPH63_11605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LPH63_11640	COG2027	D-alanyl-D-alanine carboxypeptidase
LPH63_11655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LPH63_11660	COG1752	Esterase of the alpha-beta hydrolase superfamily
LPH63_11665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LPH63_11670	COG1040	competence protein
LPH63_11705	COG0210	DNA helicase
LPH63_11710	COG0439	Biotin carboxylase
LPH63_11715	COG0511	ligase activity, forming carbon-carbon bonds
LPH63_11725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LPH63_11735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LPH63_11805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LPH63_11830	COG0408	coproporphyrinogen oxidase activity
LPH63_11875	COG0501	Belongs to the peptidase M48B family
LPH63_11885	COG0187	DNA topoisomerase II activity
LPH63_11890	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LPH63_11900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids