locus-tag	class	description
CEW88_00005	COG0277	FAD linked oxidase domain protein
CEW88_00010	COG0277	FAD linked oxidase domain protein
CEW88_00015	COG0247	lactate metabolic process
CEW88_00020	COG3591	Belongs to the peptidase S1B family
CEW88_00025	COG3591	Belongs to the peptidase S1B family
CEW88_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
CEW88_00055	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_00075	COG0437	4 iron, 4 sulfur cluster binding
CEW88_00080	COG0243	molybdopterin cofactor binding
CEW88_00095	COG0438	transferase activity, transferring glycosyl groups
CEW88_00140	COG0673	inositol 2-dehydrogenase activity
CEW88_00145	COG0489	protein tyrosine kinase activity
CEW88_00185	COG0438	transferase activity, transferring glycosyl groups
CEW88_00195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW88_00225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEW88_00225	COG0517	IMP dehydrogenase activity
CEW88_00230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW88_00235	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW88_00240	COG1346	cytolysis
CEW88_00245	COG1380	Effector of murein hydrolase LrgA
CEW88_00270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEW88_00275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEW88_00300	COG1115	amino acid carrier protein
CEW88_00310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CEW88_00320	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CEW88_00330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CEW88_00335	COG1999	signal sequence binding
CEW88_00350	COG0802	atpase or kinase
CEW88_00355	COG3178	'Phosphotransferase
CEW88_00360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW88_00365	COG2887	Belongs to the helicase family. UvrD subfamily
CEW88_00370	COG1074	ATP-dependent DNA helicase activity
CEW88_00385	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEW88_00390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CEW88_00410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW88_00420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW88_00425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CEW88_00460	COG3034	peptidoglycan biosynthetic process
CEW88_00470	COG1132	(ABC) transporter
CEW88_00475	COG1132	(ABC) transporter
CEW88_00490	COG0494	nUDIX hydrolase
CEW88_00495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEW88_00505	COG0745	RESPONSE REGULATOR receiver
CEW88_00515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_00525	COG0137	argininosuccinate synthase activity
CEW88_00535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW88_00540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CEW88_00540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CEW88_00545	COG0280	phosphate acetyltransferase
CEW88_00545	COG0281	malic enzyme
CEW88_00550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEW88_00555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEW88_00560	COG1420	regulation of RNA biosynthetic process
CEW88_00565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CEW88_00570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEW88_00575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW88_00580	COG1475	DNA binding
CEW88_00585	COG1192	Involved in chromosome partitioning
CEW88_00590	COG0357	Ribosomal RNA small subunit methyltransferase G
CEW88_00595	COG0445	tRNA wobble uridine modification
CEW88_00600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW88_00605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CEW88_00610	COG0424	maF-like protein
CEW88_00615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_00620	COG0237	dephospho-CoA kinase activity
CEW88_00625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEW88_00630	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CEW88_00635	COG3030	protein affecting phage T7 exclusion by the F plasmid
CEW88_00655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CEW88_00660	COG3474	cytochrome
CEW88_00665	COG1596	polysaccharide export
CEW88_00680	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_00685	COG1360	Flagellar Motor Protein
CEW88_00705	COG1706	bacterial-type flagellum-dependent cell motility
CEW88_00725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW88_00750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEW88_00760	COG4786	Flagellar basal body rod
CEW88_00765	COG4786	Flagellar basal body rod
CEW88_00770	COG1987	bacterial-type flagellum assembly
CEW88_00775	COG1677	Flagellar hook-basal body complex protein FliE
CEW88_00780	COG1558	bacterial-type flagellum-dependent cell motility
CEW88_00790	COG1157	protein secretion by the type III secretion system
CEW88_00800	COG5443	negative regulation of bacterial-type flagellum assembly
CEW88_00840	COG2226	methyltransferase
CEW88_00845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEW88_00860	COG0268	Binds directly to 16S ribosomal RNA
CEW88_00865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEW88_00870	COG0592	DNA-directed DNA polymerase activity
CEW88_00875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEW88_00880	COG0187	DNA topoisomerase II activity
CEW88_00935	COG0601	transmembrane transport
CEW88_00940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_00945	COG4172	Belongs to the ABC transporter superfamily
CEW88_00955	COG0697	spore germination
CEW88_00960	COG0473	3-isopropylmalate dehydrogenase activity
CEW88_00975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CEW88_00985	COG0066	3-isopropylmalate dehydratase activity
CEW88_01000	COG3264	Mechanosensitive ion channel
CEW88_01000	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEW88_01005	COG0183	Belongs to the thiolase family
CEW88_01015	COG0784	Response regulator, receiver
CEW88_01015	COG2198	Histidine kinase
CEW88_01015	COG5002	protein histidine kinase activity
CEW88_01020	COG3022	response to hydroperoxide
CEW88_01025	COG0514	ATP-dependent DNA helicase (RecQ)
CEW88_01035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CEW88_01045	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CEW88_01075	COG0583	DNA-binding transcription factor activity
CEW88_01080	COG1960	acyl-CoA dehydrogenase activity
CEW88_01085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_01095	COG0019	diaminopimelate decarboxylase activity
CEW88_01110	COG0165	Argininosuccinate lyase
CEW88_01115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW88_01130	COG0287	Prephenate dehydrogenase
CEW88_01135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW88_01140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CEW88_01145	COG1335	isochorismatase
CEW88_01155	COG1338	Plays a role in the flagellum-specific transport system
CEW88_01160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_01170	COG1766	The M ring may be actively involved in energy transduction
CEW88_01190	COG3118	belongs to the thioredoxin family
CEW88_01195	COG1376	ErfK ybiS ycfS ynhG family protein
CEW88_01210	COG4181	ATPase activity
CEW88_01220	COG0483	inositol monophosphate 1-phosphatase activity
CEW88_01225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW88_01225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW88_01230	COG0509	glycine decarboxylation via glycine cleavage system
CEW88_01235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_01240	COG1959	2 iron, 2 sulfur cluster binding
CEW88_01250	COG4325	translation initiation factor activity
CEW88_01255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW88_01265	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CEW88_01270	COG3128	pkhd-type hydroxylase
CEW88_01310	COG3842	ATPase activity
CEW88_01320	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_01335	COG1648	precorrin-2 dehydrogenase activity
CEW88_01335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW88_01340	COG0243	molybdopterin cofactor binding
CEW88_01345	COG2146	nitrite reductase [NAD(P)H] activity
CEW88_01350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW88_01355	COG1116	anion transmembrane transporter activity
CEW88_01360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_01365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_01370	COG1116	anion transmembrane transporter activity
CEW88_01370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_01375	COG3707	response regulator
CEW88_01380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_01385	COG1177	transmembrane transport
CEW88_01390	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_01395	COG3842	ATPase activity
CEW88_01405	COG1802	Transcriptional regulator
CEW88_01415	COG0004	ammonium transporteR
CEW88_01420	COG0347	Belongs to the P(II) protein family
CEW88_01425	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEW88_01430	COG0284	orotidine-5'-phosphate decarboxylase activity
CEW88_01435	COG0180	Tryptophanyl-tRNA synthetase
CEW88_01460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEW88_01475	COG1322	Protein conserved in bacteria
CEW88_01480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEW88_01485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEW88_01500	COG2169	Transcriptional regulator
CEW88_01500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW88_01510	COG2186	Transcriptional regulator
CEW88_01515	COG0314	molybdopterin synthase activity
CEW88_01525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEW88_01530	COG1381	Involved in DNA repair and RecF pathway recombination
CEW88_01545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEW88_01550	COG0697	spore germination
CEW88_01555	COG0571	ribonuclease III activity
CEW88_01560	COG0681	Belongs to the peptidase S26 family
CEW88_01565	COG0736	holo-[acyl-carrier-protein] synthase activity
CEW88_01570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CEW88_01580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW88_01585	COG1758	RNA polymerase activity
CEW88_01590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEW88_01600	COG1238	metal cluster binding
CEW88_01605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEW88_01615	COG0328	RNA-DNA hybrid ribonuclease activity
CEW88_01625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CEW88_01630	COG0242	peptide deformylase activity
CEW88_01635	COG0242	peptide deformylase activity
CEW88_01640	COG0242	peptide deformylase activity
CEW88_01645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW88_01655	COG0435	Glutathione S-transferase
CEW88_01675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_01685	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_01690	COG1024	Enoyl-CoA hydratase
CEW88_01695	COG0840	transmembrane signaling receptor activity
CEW88_01705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CEW88_01725	COG2171	N-acyltransferase activity
CEW88_01730	COG0346	lactoylglutathione lyase activity
CEW88_01735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_01760	COG0288	reversible hydration of carbon dioxide
CEW88_01770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEW88_01775	COG0791	NLP P60 protein
CEW88_01800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_01805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW88_01810	COG0659	secondary active sulfate transmembrane transporter activity
CEW88_01815	COG0254	rRNA binding
CEW88_01820	COG0335	large ribosomal subunit rRNA binding
CEW88_01825	COG0336	Belongs to the RNA methyltransferase TrmD family
CEW88_01835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEW88_01845	COG0228	four-way junction DNA binding
CEW88_01870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEW88_01900	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW88_01905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW88_01910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW88_01915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW88_01920	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW88_01920	COG0489	protein tyrosine kinase activity
CEW88_01940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEW88_01945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CEW88_01950	COG0747	negative chemotaxis
CEW88_01955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_01965	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CEW88_01985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW88_02000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW88_02005	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEW88_02010	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW88_02015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW88_02045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEW88_02060	COG0540	Belongs to the ATCase OTCase family
CEW88_02065	COG0742	ribosomal rna small subunit methyltransferase
CEW88_02080	COG2154	pterin-4-alpha-carbinolamine dehydratase
CEW88_02100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_02105	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CEW88_02110	COG2853	Lipoprotein
CEW88_02125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CEW88_02130	COG0069	glutamate synthase activity
CEW88_02135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW88_02140	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CEW88_02190	COG0250	Participates in transcription elongation, termination and antitermination
CEW88_02195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEW88_02200	COG0081	regulation of translation
CEW88_02210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEW88_02215	COG0222	ribosome binding
CEW88_02220	COG0085	RNA polymerase activity
CEW88_02225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEW88_02240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEW88_02245	COG0049	tRNA binding
CEW88_02250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEW88_02255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW88_02260	COG0051	transcription antitermination factor activity, RNA binding
CEW88_02265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEW88_02270	COG0088	Forms part of the polypeptide exit tunnel
CEW88_02275	COG0089	rRNA binding
CEW88_02280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEW88_02285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEW88_02290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEW88_02295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEW88_02300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEW88_02310	COG0255	Belongs to the universal ribosomal protein uL29 family
CEW88_02315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEW88_02320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEW88_02325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEW88_02330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEW88_02335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEW88_02340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEW88_02345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEW88_02350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEW88_02355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEW88_02360	COG1841	ribosomal large subunit assembly
CEW88_02365	COG0200	Binds to the 23S rRNA
CEW88_02370	COG0201	protein transport
CEW88_02385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEW88_02390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEW88_02395	COG0202	RNA polymerase activity
CEW88_02400	COG0203	ribosomal protein L17
CEW88_02410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEW88_02435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEW88_02435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEW88_02440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEW88_02445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEW88_02450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW88_02450	COG2169	Transcriptional regulator
CEW88_02455	COG2885	chlorophyll binding
CEW88_02465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEW88_02480	COG1137	ATPase activity
CEW88_02485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEW88_02490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW88_02515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEW88_02520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CEW88_02545	COG3145	DNA-N1-methyladenine dioxygenase activity
CEW88_02550	COG0443	Heat shock 70 kDa protein
CEW88_02560	COG2003	Belongs to the UPF0758 family
CEW88_02575	COG0653	protein targeting
CEW88_02580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW88_02585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CEW88_02590	COG0494	nUDIX hydrolase
CEW88_02600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEW88_02615	COG0779	Required for maturation of 30S ribosomal subunits
CEW88_02640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEW88_02645	COG0142	geranyltranstransferase activity
CEW88_02665	COG0346	lactoylglutathione lyase activity
CEW88_02670	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_02685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEW88_02690	COG0493	'glutamate synthase
CEW88_02700	COG1309	transcriptional regulator
CEW88_02725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_02730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_02735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_02750	COG1609	Transcriptional regulator
CEW88_02760	COG2755	lipolytic protein G-D-S-L family
CEW88_02760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CEW88_02770	COG0583	DNA-binding transcription factor activity
CEW88_02775	COG1136	(ABC) transporter
CEW88_02775	COG0577	efflux transmembrane transporter activity
CEW88_02795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEW88_02815	COG1522	sequence-specific DNA binding
CEW88_02820	COG0492	ferredoxin-NADP+ reductase activity
CEW88_02855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW88_02860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_02865	COG1435	thymidine kinase activity
CEW88_02880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW88_02885	COG0471	metal ion transport
CEW88_02885	COG3273	potassium ion transport
CEW88_02895	COG0842	Transport permease protein
CEW88_02900	COG1183	phosphatidylcholine synthase activity
CEW88_02910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW88_02915	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEW88_02935	COG2244	polysaccharide biosynthetic process
CEW88_02985	COG0297	glycogen (starch) synthase activity
CEW88_03000	COG1960	acyl-CoA dehydrogenase activity
CEW88_03010	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_03015	COG1024	Enoyl-CoA hydratase
CEW88_03035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_03060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW88_03065	COG0778	Nitroreductase
CEW88_03070	COG0072	phenylalanine-tRNA ligase activity
CEW88_03070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW88_03075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CEW88_03110	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_03125	COG0463	Glycosyl transferase, family 2
CEW88_03130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEW88_03135	COG1278	Cold shock
CEW88_03145	COG0488	(ABC) transporter
CEW88_03165	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CEW88_03180	COG2894	cell division
CEW88_03190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CEW88_03215	COG1832	CoA-binding protein
CEW88_03220	COG0140	phosphoribosyl-ATP diphosphatase activity
CEW88_03225	COG0107	imidazoleglycerol-phosphate synthase activity
CEW88_03230	COG0737	Belongs to the 5'-nucleotidase family
CEW88_03250	COG1393	Belongs to the ArsC family
CEW88_03255	COG0116	Belongs to the methyltransferase superfamily
CEW88_03255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW88_03265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEW88_03270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEW88_03275	COG0131	Imidazoleglycerol-phosphate dehydratase
CEW88_03295	COG0210	DNA helicase
CEW88_03300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CEW88_03340	COG0527	aspartate kinase activity
CEW88_03345	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_03360	COG1519	Transferase
CEW88_03375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEW88_03375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEW88_03380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CEW88_03385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW88_03430	COG0564	pseudouridine synthase activity
CEW88_03435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW88_03455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEW88_03460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_03465	COG0174	glutamine synthetase
CEW88_03475	COG0174	glutamine synthetase
CEW88_03480	COG4160	amino acid transport
CEW88_03485	COG4215	(ABC) transporter
CEW88_03510	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CEW88_03520	COG0504	CTP synthase activity
CEW88_03545	COG0616	signal peptide processing
CEW88_03545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEW88_03565	COG0322	excinuclease ABC activity
CEW88_03570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEW88_03575	COG0012	GTP binding
CEW88_03580	COG0534	Mate efflux family protein
CEW88_03600	COG2326	polyphosphate kinase activity
CEW88_03610	COG0159	tryptophan synthase activity
CEW88_03620	COG2084	Dehydrogenase
CEW88_03625	COG3395	kinase activity
CEW88_03630	COG0235	Class ii aldolase
CEW88_03635	COG3622	Belongs to the hyi family
CEW88_03640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_03650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEW88_03660	COG0277	FAD linked oxidase domain protein
CEW88_03675	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_03680	COG2084	Dehydrogenase
CEW88_03685	COG1609	Transcriptional regulator
CEW88_03700	COG0129	dihydroxy-acid dehydratase activity
CEW88_03705	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_03710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_03715	COG0697	spore germination
CEW88_03720	COG2721	sulfolactate sulfo-lyase activity
CEW88_03740	COG1802	Transcriptional regulator
CEW88_03800	COG0753	catalase activity
CEW88_03810	COG1216	Glycosyl transferase, family 2
CEW88_03830	COG1295	ribonuclease BN
CEW88_03855	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CEW88_03865	COG1215	transferase activity, transferring glycosyl groups
CEW88_03890	COG3174	membrane
CEW88_03905	COG2197	response regulator
CEW88_03910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_03950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_03955	COG1120	ATPase activity
CEW88_03965	COG1522	sequence-specific DNA binding
CEW88_03975	COG2072	flavoprotein involved in K transport
CEW88_04000	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_04005	COG1177	transmembrane transport
CEW88_04010	COG3842	ATPase activity
CEW88_04025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CEW88_04035	COG0435	Glutathione S-transferase
CEW88_04040	COG2514	catechol 2,3-dioxygenase activity
CEW88_04050	COG0321	lipoyl(octanoyl) transferase activity
CEW88_04070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW88_04075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEW88_04080	COG0667	Aldo Keto reductase
CEW88_04085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEW88_04135	COG2894	cell division
CEW88_04145	COG4964	Belongs to the GSP D family
CEW88_04165	COG1643	Atp-dependent helicase
CEW88_04190	COG1703	isobutyryl-CoA mutase activity
CEW88_04195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEW88_04200	COG2847	Copper chaperone PCu(A)C
CEW88_04205	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEW88_04210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEW88_04220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEW88_04225	COG3768	UPF0283 membrane protein
CEW88_04235	COG3106	COG3106 Predicted ATPase
CEW88_04240	COG0101	tRNA pseudouridine synthase activity
CEW88_04245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW88_04250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEW88_04255	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CEW88_04280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_04300	COG0174	glutamine synthetase
CEW88_04305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW88_04325	COG1674	ftsk spoiiie
CEW88_04330	COG3246	L-lysine catabolic process to acetate
CEW88_04335	COG1802	Transcriptional regulator
CEW88_04340	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_04365	COG0481	GTPase activity
CEW88_04380	COG0583	DNA-binding transcription factor activity
CEW88_04385	COG0596	Alpha beta hydrolase
CEW88_04425	COG3706	GGDEF domain
CEW88_04425	COG0745	RESPONSE REGULATOR receiver
CEW88_04500	COG3590	peptidase
CEW88_04505	COG3596	GTP binding
CEW88_04510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW88_04520	COG0745	RESPONSE REGULATOR receiver
CEW88_04525	COG1607	acyl-coa hydrolase
CEW88_04535	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_04565	COG1692	metallophosphoesterase
CEW88_04575	COG3273	potassium ion transport
CEW88_04575	COG0471	metal ion transport
CEW88_04580	COG0217	transcriptional regulatory protein
CEW88_04610	COG0596	Alpha beta hydrolase
CEW88_04620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEW88_04640	COG0670	Belongs to the BI1 family
CEW88_04650	COG0583	DNA-binding transcription factor activity
CEW88_04660	COG1396	sequence-specific DNA binding
CEW88_04665	COG0483	inositol monophosphate 1-phosphatase activity
CEW88_04685	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_04690	COG2239	Acts as a magnesium transporter
CEW88_04695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEW88_04700	COG0151	Belongs to the GarS family
CEW88_04705	COG1570	exodeoxyribonuclease VII activity
CEW88_04715	COG0741	lytic transglycosylase activity
CEW88_04720	COG0552	protein localization to endoplasmic reticulum
CEW88_04725	COG1285	pathogenesis
CEW88_04730	COG2917	probably involved in intracellular septation
CEW88_04735	COG0477	Major facilitator Superfamily
CEW88_04745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEW88_04760	COG0084	hydrolase, TatD family'
CEW88_04895	COG4373	Mu-like prophage FluMu protein gp28
CEW88_04930	COG4397	Mu-like prophage major head subunit gpT
CEW88_04995	COG2001	Belongs to the MraZ family
CEW88_05000	COG0275	rRNA processing
CEW88_05015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEW88_05025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEW88_05030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEW88_05040	COG2081	HI0933 family
CEW88_05050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEW88_05055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEW88_05070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEW88_05075	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEW88_05080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEW88_05085	COG0849	cell division
CEW88_05090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEW88_05100	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_05110	COG0525	valine-tRNA ligase activity
CEW88_05120	COG0489	protein tyrosine kinase activity
CEW88_05130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEW88_05150	COG2197	response regulator
CEW88_05155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_05185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEW88_05190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_05195	COG0601	transmembrane transport
CEW88_05205	COG4172	Belongs to the ABC transporter superfamily
CEW88_05210	COG0850	regulation of cytokinetic process
CEW88_05215	COG2894	cell division
CEW88_05220	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CEW88_05225	COG0443	Heat shock 70 kDa protein
CEW88_05230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_05240	COG1473	amidohydrolase
CEW88_05245	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW88_05250	COG0642	Histidine kinase
CEW88_05280	COG1695	Transcriptional regulator
CEW88_05290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW88_05310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_05325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_05335	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_05340	COG3618	amidohydrolase
CEW88_05350	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CEW88_05370	COG0395	ABC-type sugar transport system, permease component
CEW88_05375	COG1175	transmembrane transport
CEW88_05395	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CEW88_05400	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_05440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CEW88_05475	COG1024	Enoyl-CoA hydratase
CEW88_05475	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_05485	COG3750	Belongs to the UPF0335 family
CEW88_05495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CEW88_05520	COG0586	Pfam SNARE associated Golgi protein
CEW88_05525	COG2610	gluconate transmembrane transporter activity
CEW88_05530	COG1215	transferase activity, transferring glycosyl groups
CEW88_05535	COG3769	mannosylglycerate metabolic process
CEW88_05545	COG0583	DNA-binding transcription factor activity
CEW88_05550	COG1278	Cold shock
CEW88_05555	COG1393	Belongs to the ArsC family
CEW88_05560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEW88_05605	COG0386	Belongs to the glutathione peroxidase family
CEW88_05610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEW88_05625	COG1982	Orn Lys Arg decarboxylase major
CEW88_05630	COG1793	dna ligase
CEW88_05660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEW88_05670	COG1329	Transcriptional regulator
CEW88_05675	COG1252	NADH dehydrogenase
CEW88_05680	COG0475	glutathione-regulated potassium exporter activity
CEW88_05680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEW88_05690	COG1469	GTP cyclohydrolase I activity
CEW88_05700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_05705	COG0277	FAD linked oxidase domain protein
CEW88_05715	COG1764	response to oxidative stress
CEW88_05720	COG1846	Transcriptional regulator
CEW88_05765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW88_05775	COG0271	Belongs to the BolA IbaG family
CEW88_05785	COG3135	benzoate transporter
CEW88_05790	COG0523	cobalamin synthesis protein
CEW88_05810	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CEW88_05815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW88_05830	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_05835	COG0308	aminopeptidase N
CEW88_05875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_05890	COG2995	paraquat-inducible protein a
CEW88_05895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CEW88_05895	COG3008	intermembrane lipid transfer
CEW88_05915	COG5002	protein histidine kinase activity
CEW88_05915	COG2176	DNA-directed DNA polymerase activity
CEW88_05930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW88_05940	COG0563	adenylate kinase activity
CEW88_05945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW88_05955	COG5487	UPF0391 membrane protein
CEW88_05960	COG0784	Response regulator, receiver
CEW88_05985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CEW88_06000	COG1160	GTP binding
CEW88_06015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEW88_06020	COG3591	Belongs to the peptidase S1B family
CEW88_06030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW88_06035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW88_06040	COG3737	Protein of unknown function (DUF498/DUF598)
CEW88_06045	COG4133	protoheme IX ABC transporter activity
CEW88_06050	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEW88_06055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEW88_06065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW88_06105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CEW88_06105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CEW88_06120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CEW88_06130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW88_06150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_06155	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_06170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEW88_06175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEW88_06185	COG0248	Ppx GppA phosphatase
CEW88_06190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CEW88_06285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEW88_06310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW88_06315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CEW88_06320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEW88_06325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEW88_06330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW88_06335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CEW88_06350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEW88_06360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW88_06370	COG2095	MarC family integral membrane protein
CEW88_06375	COG0488	(ABC) transporter
CEW88_06380	COG0105	UTP biosynthetic process
CEW88_06390	COG0401	homolog of Blt101
CEW88_06415	COG4695	Portal protein
CEW88_06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW88_06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW88_06500	COG0022	dehydrogenase e1 component
CEW88_06505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEW88_06510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CEW88_06515	COG0126	phosphoglycerate kinase activity
CEW88_06520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEW88_06525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEW88_06540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEW88_06540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW88_06555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEW88_06560	COG0316	Belongs to the HesB IscA family
CEW88_06565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEW88_06575	COG0018	arginyl-trna synthetase
CEW88_06585	COG1472	Belongs to the glycosyl hydrolase 3 family
CEW88_06590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEW88_06595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEW88_06610	COG0717	Belongs to the dCTP deaminase family
CEW88_06625	COG0776	regulation of translation
CEW88_06630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW88_06635	COG0416	fatty acid biosynthetic process
CEW88_06640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CEW88_06675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEW88_06680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CEW88_06705	COG2885	chlorophyll binding
CEW88_06710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEW88_06720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CEW88_06740	COG0440	acetolactate synthase activity
CEW88_06745	COG0028	Belongs to the TPP enzyme family
CEW88_06765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW88_06775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_06790	COG4638	Rieske (2fe-2S)
CEW88_06795	COG0028	Belongs to the TPP enzyme family
CEW88_06805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEW88_06815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEW88_06820	COG4235	cytochrome complex assembly
CEW88_06825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_06845	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_06845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_06865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW88_06875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_06895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_06905	COG0415	Belongs to the DNA photolyase family
CEW88_06915	COG0494	nUDIX hydrolase
CEW88_06925	COG3264	Mechanosensitive ion channel
CEW88_06925	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEW88_06930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW88_06945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CEW88_06960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEW88_06970	COG0166	Belongs to the GPI family
CEW88_06995	COG3108	Peptidase M15
CEW88_07005	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_07010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW88_07025	COG2354	Protein conserved in bacteria
CEW88_07030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEW88_07060	COG0033	Phosphoglucomutase
CEW88_07075	COG0297	glycogen (starch) synthase activity
CEW88_07080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CEW88_07085	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEW88_07090	COG0058	SHG alpha-glucan phosphorylase activity
CEW88_07095	COG0837	glucose binding
CEW88_07100	COG2723	6-phospho-beta-galactosidase activity
CEW88_07105	COG1609	Transcriptional regulator
CEW88_07110	COG1653	transport
CEW88_07115	COG1175	transmembrane transport
CEW88_07120	COG0395	ABC-type sugar transport system, permease component
CEW88_07125	COG0366	Alpha amylase catalytic
CEW88_07130	COG3842	ATPase activity
CEW88_07135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEW88_07145	COG1024	Enoyl-CoA hydratase
CEW88_07155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEW88_07180	COG1492	cobalamin metabolic process
CEW88_07190	COG0538	isocitrate dehydrogenase activity
CEW88_07195	COG2814	Major facilitator Superfamily
CEW88_07210	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CEW88_07215	COG1960	acyl-CoA dehydrogenase activity
CEW88_07220	COG0438	transferase activity, transferring glycosyl groups
CEW88_07225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_07235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW88_07240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEW88_07245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CEW88_07255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEW88_07265	COG2166	iron-sulfur cluster assembly
CEW88_07270	COG0233	cytoplasmic translational termination
CEW88_07275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEW88_07280	COG0575	Belongs to the CDS family
CEW88_07285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEW88_07290	COG0750	zinc metalloprotease
CEW88_07295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_07305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEW88_07310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_07320	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW88_07330	COG0433	COG0433 Predicted ATPase
CEW88_07345	COG4166	transmembrane transport
CEW88_07350	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_07370	COG2313	pseudouridylate synthase activity
CEW88_07385	COG0586	Pfam SNARE associated Golgi protein
CEW88_07390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEW88_07395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEW88_07400	COG0052	Belongs to the universal ribosomal protein uS2 family
CEW88_07425	COG0745	RESPONSE REGULATOR receiver
CEW88_07430	COG0704	Plays a role in the regulation of phosphate uptake
CEW88_07435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW88_07440	COG0581	inorganic phosphate transmembrane transporter activity
CEW88_07445	COG0573	inorganic phosphate transmembrane transporter activity
CEW88_07455	COG5002	protein histidine kinase activity
CEW88_07460	COG0626	cystathionine gamma-synthase activity
CEW88_07475	COG0194	GDP metabolic process
CEW88_07480	COG1561	YicC-like family, N-terminal region
CEW88_07490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CEW88_07495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEW88_07505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CEW88_07510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CEW88_07565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEW88_07580	COG1278	Cold shock
CEW88_07585	COG0259	pyridoxamine-phosphate oxidase activity
CEW88_07590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEW88_07595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CEW88_07600	COG0702	epimerase
CEW88_07605	COG1733	regulation of RNA biosynthetic process
CEW88_07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEW88_07630	COG2032	superoxide dismutase activity
CEW88_07640	COG0646	methionine synthase
CEW88_07640	COG1410	methionine synthase
CEW88_07650	COG5012	cobalamin binding
CEW88_07665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEW88_07670	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEW88_07675	COG0134	indole-3-glycerol-phosphate synthase activity
CEW88_07685	COG0303	'Molybdopterin
CEW88_07690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEW88_07695	COG2333	competence protein COMEC
CEW88_07695	COG0658	competence protein
CEW88_07700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW88_07705	COG0372	Belongs to the citrate synthase family
CEW88_07710	COG0372	Belongs to the citrate synthase family
CEW88_07715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_07720	COG1024	Enoyl-CoA hydratase
CEW88_07725	COG3088	subunit of a heme lyase
CEW88_07730	COG1138	Cytochrome C-type biogenesis protein
CEW88_07740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEW88_07745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEW88_07745	COG3743	rRNA binding
CEW88_07770	COG1238	metal cluster binding
CEW88_07810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEW88_07815	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CEW88_07820	COG0583	DNA-binding transcription factor activity
CEW88_07850	COG2059	Chromate
CEW88_07860	COG0114	fumarate hydratase activity
CEW88_07875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEW88_07915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_07920	COG0642	Histidine kinase
CEW88_07925	COG0745	RESPONSE REGULATOR receiver
CEW88_07930	COG1376	ErfK ybiS ycfS ynhG family protein
CEW88_07940	COG1070	Carbohydrate kinase
CEW88_07965	COG1175	transmembrane transport
CEW88_07990	COG0805	protein transport
CEW88_08000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEW88_08005	COG2378	regulation of single-species biofilm formation
CEW88_08015	COG2353	YceI-like domain
CEW88_08025	COG0360	Binds together with S18 to 16S ribosomal RNA
CEW88_08030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEW88_08035	COG0359	binds to the 23S rRNA
CEW88_08045	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEW88_08050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEW88_08070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CEW88_08080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEW88_08085	COG5265	(ABC) transporter
CEW88_08110	COG3588	fructose-bisphosphate aldolase
CEW88_08115	COG2124	cytochrome p450
CEW88_08125	COG0785	Cytochrome C biogenesis protein
CEW88_08130	COG1530	ribonuclease E activity
CEW88_08140	COG2084	Dehydrogenase
CEW88_08155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEW88_08160	COG1923	regulation of RNA biosynthetic process
CEW88_08165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_08170	COG0569	domain protein
CEW88_08175	COG2204	response regulator
CEW88_08180	COG5000	phosphorelay sensor kinase activity
CEW88_08185	COG2204	response regulator
CEW88_08190	COG3852	Histidine kinase
CEW88_08195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEW88_08200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEW88_08200	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEW88_08215	COG2867	negative regulation of translational initiation
CEW88_08230	COG2010	Cytochrome c
CEW88_08235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CEW88_08245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW88_08250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CEW88_08260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEW88_08265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEW88_08285	COG0482	sulfurtransferase activity
CEW88_08300	COG2204	response regulator
CEW88_08310	COG0047	phosphoribosylformylglycinamidine synthase activity
CEW88_08315	COG1063	alcohol dehydrogenase
CEW88_08320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CEW88_08330	COG2326	polyphosphate kinase activity
CEW88_08355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEW88_08360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_08370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEW88_08375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEW88_08385	COG4974	Belongs to the 'phage' integrase family
CEW88_08390	COG0528	UMP kinase activity
CEW88_08395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEW88_08410	COG1858	cytochrome C peroxidase
CEW88_08415	COG0741	lytic transglycosylase activity
CEW88_08420	COG0629	single-stranded DNA binding
CEW88_08435	COG4536	flavin adenine dinucleotide binding
CEW88_08455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEW88_08460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEW88_08470	COG2205	protein histidine kinase activity
CEW88_08560	COG2207	Transcriptional regulator
CEW88_08565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW88_08610	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_08720	COG0714	Associated with various cellular activities
CEW88_08730	COG3119	arylsulfatase activity
CEW88_08740	COG0753	catalase activity
CEW88_08770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEW88_08770	COG0519	Catalyzes the synthesis of GMP from XMP
CEW88_08790	COG0840	transmembrane signaling receptor activity
CEW88_08825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW88_08855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CEW88_08865	COG0024	Methionine aminopeptidase
CEW88_08870	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CEW88_08875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEW88_08890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEW88_08905	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEW88_08910	COG1612	heme a metabolic process
CEW88_08930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CEW88_08930	COG0352	thiamine-phosphate diphosphorylase activity
CEW88_08955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEW88_08960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEW88_08965	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEW88_08985	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW88_08995	COG0316	Belongs to the HesB IscA family
CEW88_09000	COG0149	triose-phosphate isomerase activity
CEW88_09005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_09010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_09015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_09030	COG2124	cytochrome p450
CEW88_09040	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CEW88_09065	COG0713	ATP synthesis coupled electron transport
CEW88_09080	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW88_09085	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CEW88_09140	COG0649	NAD binding
CEW88_09145	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW88_09150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW88_09160	COG1024	Enoyl-CoA hydratase
CEW88_09170	COG0625	glutathione transferase activity
CEW88_09180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW88_09185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW88_09195	COG1960	acyl-CoA dehydrogenase activity
CEW88_09210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_09215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEW88_09220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW88_09225	COG0513	Belongs to the DEAD box helicase family
CEW88_09230	COG1764	response to oxidative stress
CEW88_09240	COG1522	sequence-specific DNA binding
CEW88_09250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW88_09255	COG0175	sulfate reduction
CEW88_09280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEW88_09290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CEW88_09300	COG0546	phosphoglycolate phosphatase activity
CEW88_09305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEW88_09315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEW88_09330	COG0719	Fe-S assembly protein
CEW88_09335	COG0396	ATPase activity
CEW88_09345	COG0393	Putative heavy-metal-binding
CEW88_09355	COG0719	Fe-S assembly protein
CEW88_09365	COG1959	2 iron, 2 sulfur cluster binding
CEW88_09370	COG2945	thiolester hydrolase activity
CEW88_09385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW88_09410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CEW88_09420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW88_09425	COG0739	heme binding
CEW88_09460	COG2814	Major facilitator Superfamily
CEW88_09470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW88_09475	COG0215	cysteine-tRNA ligase activity
CEW88_09485	COG2890	protein-(glutamine-N5) methyltransferase activity
CEW88_09490	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEW88_09505	COG0010	Belongs to the arginase family
CEW88_09510	COG1473	amidohydrolase
CEW88_09515	COG1473	amidohydrolase
CEW88_09520	COG3956	TIGRFAM MazG family protein
CEW88_09525	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW88_09530	COG3454	Phosphonate metabolism
CEW88_09545	COG4778	phosphonate C-P lyase system protein PhnL
CEW88_09550	COG4107	phosphonate C-P lyase system protein PhnK
CEW88_09555	COG3627	carbon phosphorus lyase activity
CEW88_09565	COG3626	phosphonate metabolism
CEW88_09570	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CEW88_09575	COG3624	Phosphonate C-P lyase system protein PhnG
CEW88_09580	COG2188	Transcriptional regulator
CEW88_09595	COG0840	transmembrane signaling receptor activity
CEW88_09605	COG3639	organic phosphonate transmembrane transporter activity
CEW88_09615	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CEW88_09620	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CEW88_09635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CEW88_09660	COG1846	Transcriptional regulator
CEW88_09665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_09670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_09680	COG2943	transferase activity, transferring hexosyl groups
CEW88_09685	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CEW88_09700	COG0154	amidase activity
CEW88_09705	COG0444	Belongs to the ABC transporter superfamily
CEW88_09710	COG4608	Belongs to the ABC transporter superfamily
CEW88_09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_09750	COG0183	Belongs to the thiolase family
CEW88_09755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CEW88_09765	COG1414	Transcriptional regulator
CEW88_09780	COG0330	HflC and HflK could
CEW88_09785	COG0330	HflC and HflK could
CEW88_09795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CEW88_09800	COG1760	l-serine dehydratase
CEW88_09830	COG4603	Belongs to the binding-protein-dependent transport system permease family
CEW88_09840	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_09855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEW88_09895	COG1136	(ABC) transporter
CEW88_09905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW88_09915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CEW88_09925	COG1132	(ABC) transporter
CEW88_09930	COG0354	folic acid binding
CEW88_09940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEW88_09960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW88_09975	COG0405	Gamma-glutamyltransferase
CEW88_10000	COG0745	RESPONSE REGULATOR receiver
CEW88_10005	COG3800	Transcriptional regulator
CEW88_10005	COG1396	sequence-specific DNA binding
CEW88_10015	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW88_10030	COG0410	ABC transporter
CEW88_10035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW88_10050	COG0439	Biotin carboxylase
CEW88_10055	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CEW88_10085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEW88_10090	COG0740	serine-type endopeptidase activity
CEW88_10095	COG1230	cation diffusion facilitator family transporter
CEW88_10120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEW88_10130	COG0735	belongs to the Fur family
CEW88_10145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_10150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_10155	COG1120	ATPase activity
CEW88_10165	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEW88_10170	COG1984	allophanate hydrolase subunit 2
CEW88_10175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CEW88_10180	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CEW88_10185	COG1530	ribonuclease E activity
CEW88_10195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEW88_10200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW88_10240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEW88_10250	COG2954	triphosphatase activity
CEW88_10255	COG1192	Involved in chromosome partitioning
CEW88_10275	COG0358	DNA primase activity
CEW88_10280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW88_10290	COG0586	Pfam SNARE associated Golgi protein
CEW88_10295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_10300	COG0729	surface antigen
CEW88_10315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CEW88_10325	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CEW88_10335	COG0804	urea catabolic process
CEW88_10360	COG0832	Belongs to the urease beta subunit family
CEW88_10365	COG0831	urea catabolic process
CEW88_10370	COG0829	nickel cation binding
CEW88_10380	COG0800	Aldolase
CEW88_10385	COG3734	2-keto-3-deoxy-galactonokinase
CEW88_10395	COG1830	Aldolase
CEW88_10415	COG4221	oxidoreductase activity
CEW88_10425	COG0432	Pfam Uncharacterised protein family UPF0047
CEW88_10430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEW88_10435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW88_10435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW88_10440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEW88_10475	COG4166	transmembrane transport
CEW88_10480	COG4174	ABC transporter (Permease)
CEW88_10485	COG4239	(ABC) transporter, permease
CEW88_10490	COG4172	Belongs to the ABC transporter superfamily
CEW88_10495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW88_10500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW88_10505	COG5507	3-demethylubiquinone-9 3-methyltransferase
CEW88_10540	COG2010	Cytochrome c
CEW88_10545	COG0583	DNA-binding transcription factor activity
CEW88_10550	COG0348	domain, Protein
CEW88_10580	COG1522	sequence-specific DNA binding
CEW88_10585	COG0686	Belongs to the AlaDH PNT family
CEW88_10590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEW88_10595	COG1970	mechanosensitive ion channel activity
CEW88_10625	COG0768	penicillin binding
CEW88_10630	COG0772	Belongs to the SEDS family
CEW88_10635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_10645	COG0659	secondary active sulfate transmembrane transporter activity
CEW88_10650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CEW88_10655	COG1280	lysine exporter protein (LysE YggA)
CEW88_10670	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW88_10690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEW88_10695	COG0758	DNA mediated transformation
CEW88_10700	COG0312	modulator of DNA gyrase
CEW88_10710	COG0109	protoheme IX farnesyltransferase activity
CEW88_10720	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CEW88_10730	COG3346	SURF1 family
CEW88_10740	COG0612	Peptidase, M16
CEW88_10765	COG4134	Bacterial extracellular solute-binding protein
CEW88_10770	COG4135	transport system, permease component
CEW88_10775	COG4136	ATPase activity
CEW88_10780	COG1070	Carbohydrate kinase
CEW88_10790	COG2816	NAD+ diphosphatase activity
CEW88_10795	COG0737	Belongs to the 5'-nucleotidase family
CEW88_10805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_10810	COG1116	anion transmembrane transporter activity
CEW88_10815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_10845	COG2205	protein histidine kinase activity
CEW88_10845	COG5002	protein histidine kinase activity
CEW88_10845	COG0784	Response regulator, receiver
CEW88_10850	COG1215	transferase activity, transferring glycosyl groups
CEW88_10855	COG1216	Glycosyl transferase, family 2
CEW88_10915	COG1366	Belongs to the anti-sigma-factor antagonist family
CEW88_10925	COG0564	pseudouridine synthase activity
CEW88_10940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEW88_10945	COG0135	phosphoribosylanthranilate isomerase activity
CEW88_10955	COG0776	regulation of translation
CEW88_10965	COG0539	negative regulation of cytoplasmic translation
CEW88_10970	COG3284	Transcriptional regulator
CEW88_10975	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_10995	COG2968	Membrane
CEW88_11005	COG0751	glycine-tRNA ligase activity
CEW88_11010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEW88_11010	COG0574	Belongs to the PEP-utilizing enzyme family
CEW88_11015	COG3773	Cell wall hydrolase
CEW88_11015	COG3409	Peptidoglycan-binding domain 1 protein
CEW88_11020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEW88_11025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEW88_11030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEW88_11035	COG0534	Mate efflux family protein
CEW88_11065	COG0625	glutathione transferase activity
CEW88_11070	COG0183	Belongs to the thiolase family
CEW88_11080	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_11080	COG1024	Enoyl-CoA hydratase
CEW88_11110	COG0813	purine-nucleoside phosphorylase activity
CEW88_11150	COG2030	dehydratase
CEW88_11165	COG2301	Belongs to the HpcH HpaI aldolase family
CEW88_11175	COG1732	Glycine betaine
CEW88_11180	COG1174	glycine betaine transport
CEW88_11185	COG1125	glycine betaine transport
CEW88_11190	COG1174	glycine betaine transport
CEW88_11195	COG0039	L-malate dehydrogenase activity
CEW88_11200	COG0045	succinate-CoA ligase (ADP-forming) activity
CEW88_11205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CEW88_11210	COG0567	Dehydrogenase, E1 component
CEW88_11215	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW88_11255	COG2884	Cell division ATP-binding protein ftsE
CEW88_11265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_11270	COG1116	anion transmembrane transporter activity
CEW88_11285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_11300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEW88_11320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEW88_11325	COG0602	queuosine metabolic process
CEW88_11330	COG0720	synthase
CEW88_11335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEW88_11340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CEW88_11345	COG0142	geranyltranstransferase activity
CEW88_11350	COG1722	exodeoxyribonuclease VII activity
CEW88_11355	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEW88_11360	COG0745	RESPONSE REGULATOR receiver
CEW88_11365	COG1846	Transcriptional regulator
CEW88_11370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEW88_11385	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_11395	COG3842	ATPase activity
CEW88_11400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_11415	COG0745	RESPONSE REGULATOR receiver
CEW88_11425	COG1185	polyribonucleotide nucleotidyltransferase activity
CEW88_11430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEW88_11445	COG2835	tetraacyldisaccharide 4'-kinase activity
CEW88_11465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_11480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEW88_11485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEW88_11495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEW88_11500	COG1702	phosphate starvation-inducible protein PhoH
CEW88_11510	COG2885	chlorophyll binding
CEW88_11515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW88_11535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEW88_11540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW88_11545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEW88_11605	COG1061	Type III restriction enzyme res subunit
CEW88_11675	COG1522	sequence-specific DNA binding
CEW88_11685	COG0840	transmembrane signaling receptor activity
CEW88_11690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEW88_11695	COG4143	(ABC) transporter
CEW88_11705	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CEW88_11730	COG2824	Alkylphosphonate utilization operon protein PhnA
CEW88_11735	COG1183	phosphatidylcholine synthase activity
CEW88_11745	COG0625	glutathione transferase activity
CEW88_11750	COG0459	protein refolding
CEW88_11760	COG0697	spore germination
CEW88_11775	COG0339	signal peptide processing
CEW88_11780	COG0765	amino acid transport
CEW88_11790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEW88_11795	COG0756	dUTP diphosphatase activity
CEW88_11800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEW88_11810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW88_11815	COG0606	chelatase, subunit chli
CEW88_11820	COG0657	acetylesterase activity
CEW88_11830	COG0792	nuclease activity
CEW88_11835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEW88_11845	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEW88_11850	COG1278	Cold shock
CEW88_11855	COG0513	Belongs to the DEAD box helicase family
CEW88_11860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_11870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_11880	COG0180	Tryptophanyl-tRNA synthetase
CEW88_11895	COG2255	four-way junction helicase activity
CEW88_11900	COG0632	four-way junction helicase activity
CEW88_11925	COG0408	coproporphyrinogen oxidase activity
CEW88_11930	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_11935	COG2813	Specifically methylates the guanine in position
CEW88_11940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEW88_11950	COG1686	Belongs to the peptidase S11 family
CEW88_11955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEW88_11965	COG1063	alcohol dehydrogenase
CEW88_11980	COG1047	Peptidyl-prolyl cis-trans
CEW88_11995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEW88_12015	COG0640	Transcriptional regulator
CEW88_12020	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_12025	COG1132	(ABC) transporter
CEW88_12040	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_12045	COG3806	Anti-sigma factor
CEW88_12050	COG1595	DNA-templated transcription, initiation
CEW88_12075	COG2135	peptidase activity
CEW88_12085	COG0590	tRNA wobble adenosine to inosine editing
CEW88_12090	COG1187	pseudouridine synthase activity
CEW88_12110	COG3853	Toxic anion resistance protein (TelA)
CEW88_12140	COG1490	D-aminoacyl-tRNA deacylase activity
CEW88_12160	COG1294	oxidase, subunit
CEW88_12170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CEW88_12175	COG4988	ABC transporter
CEW88_12210	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CEW88_12215	COG0594	ribonuclease P activity
CEW88_12220	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CEW88_12225	COG0037	tRNA processing
CEW88_12235	COG0706	membrane insertase activity
CEW88_12245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CEW88_12250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEW88_12255	COG2062	phosphohistidine phosphatase, SixA
CEW88_12260	COG1126	abc transporter atp-binding protein
CEW88_12265	COG0765	amino acid transport
CEW88_12270	COG4597	amino acid ABC transporter
CEW88_12275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_12285	COG0546	phosphoglycolate phosphatase activity
CEW88_12290	COG0564	pseudouridine synthase activity
CEW88_12300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEW88_12305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW88_12310	COG0560	Phosphoserine phosphatase
CEW88_12325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEW88_12335	COG2217	Heavy metal translocating P-type atpase
CEW88_12375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW88_12380	COG2096	Adenosyltransferase
CEW88_12390	COG0300	oxidoreductase activity
CEW88_12400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEW88_12430	COG1573	uracil-dna glycosylase
CEW88_12440	COG3191	aminopeptidase activity
CEW88_12455	COG4172	Belongs to the ABC transporter superfamily
CEW88_12475	COG3454	Phosphonate metabolism
CEW88_12480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CEW88_12485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEW88_12490	COG0039	L-malate dehydrogenase activity
CEW88_12505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CEW88_12510	COG0745	RESPONSE REGULATOR receiver
CEW88_12515	COG2205	protein histidine kinase activity
CEW88_12525	COG1660	Displays ATPase and GTPase activities
CEW88_12535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW88_12545	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_12565	COG4638	Rieske (2fe-2S)
CEW88_12580	COG0469	pyruvate kinase activity
CEW88_12585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEW88_12590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEW88_12595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEW88_12615	COG0495	leucyl-tRNA aminoacylation
CEW88_12635	COG0457	Tetratricopeptide repeat
CEW88_12640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CEW88_12645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_12650	COG0196	riboflavin kinase activity
CEW88_12655	COG2983	Belongs to the UPF0260 family
CEW88_12685	COG0436	Aminotransferase
CEW88_12690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_12695	COG0557	exoribonuclease II activity
CEW88_12705	COG2378	regulation of single-species biofilm formation
CEW88_12710	COG2951	lytic endotransglycosylase activity
CEW88_12720	COG1051	belongs to the nudix hydrolase family
CEW88_12725	COG0793	Belongs to the peptidase S41A family
CEW88_12735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CEW88_12740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_12780	COG1872	DUF167
CEW88_12785	COG0778	Nitroreductase
CEW88_12825	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEW88_12830	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEW88_12835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEW88_12855	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW88_12870	COG0725	ABC transporter, periplasmic molybdate-binding protein
CEW88_12875	COG4149	molybdate abc transporter
CEW88_12880	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CEW88_12910	COG1266	CAAX protease self-immunity
CEW88_12915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEW88_12920	COG0285	dihydrofolate synthase activity
CEW88_12925	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CEW88_12930	COG2271	Major facilitator Superfamily
CEW88_12935	COG1073	alpha beta
CEW88_12935	COG2226	methyltransferase
CEW88_12945	COG1671	Belongs to the UPF0178 family
CEW88_12950	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CEW88_12955	COG0679	Auxin Efflux Carrier
CEW88_12965	COG1131	(ABC) transporter
CEW88_12990	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_13000	COG0714	Associated with various cellular activities
CEW88_13030	COG0277	FAD linked oxidase domain protein
CEW88_13040	COG1473	amidohydrolase
CEW88_13085	COG1074	ATP-dependent DNA helicase activity
CEW88_13130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEW88_13175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_13190	COG0587	DNA-directed DNA polymerase activity
CEW88_13200	COG2900	Belongs to the SlyX family
CEW88_13210	COG0124	histidyl-tRNA synthetase
CEW88_13220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEW88_13225	COG0625	glutathione transferase activity
CEW88_13230	COG1201	RNA secondary structure unwinding
CEW88_13240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW88_13250	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CEW88_13260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW88_13265	COG0037	tRNA processing
CEW88_13275	COG2885	chlorophyll binding
CEW88_13280	COG0823	Involved in the tonB-independent uptake of proteins
CEW88_13300	COG0824	Thioesterase
CEW88_13310	COG1403	HNH endonuclease
CEW88_13325	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_13340	COG0189	ligase activity
CEW88_13340	COG4067	protein conserved in archaea
CEW88_13355	COG1522	sequence-specific DNA binding
CEW88_13365	COG0825	malonyl-CoA metabolic process
CEW88_13400	COG1116	anion transmembrane transporter activity
CEW88_13410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_13415	COG0601	transmembrane transport
CEW88_13430	COG0747	negative chemotaxis
CEW88_13435	COG0601	transmembrane transport
CEW88_13440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_13450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_13455	COG1120	ATPase activity
CEW88_13520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEW88_13525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_13545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_13565	COG4598	ABC transporter
CEW88_13570	COG0765	amino acid transport
CEW88_13580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEW88_13585	COG0277	FAD linked oxidase domain protein
CEW88_13590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CEW88_13600	COG2986	histidine ammonia-lyase
CEW88_13605	COG1228	amidohydrolase
CEW88_13615	COG0628	permease
CEW88_13625	COG1295	ribonuclease BN
CEW88_13630	COG1597	lipid kinase activity
CEW88_13655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW88_13665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEW88_13670	COG0442	prolyl-tRNA aminoacylation
CEW88_13675	COG0628	permease
CEW88_13685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEW88_13690	COG0248	Ppx GppA phosphatase
CEW88_13705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CEW88_13730	COG0439	Biotin carboxylase
CEW88_13755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW88_13765	COG1396	sequence-specific DNA binding
CEW88_13765	COG3800	Transcriptional regulator
CEW88_13775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW88_13780	COG0154	amidase activity
CEW88_13790	COG3023	N-Acetylmuramoyl-L-alanine amidase
CEW88_13815	COG0505	Belongs to the CarA family
CEW88_13825	COG1802	Transcriptional regulator
CEW88_13845	COG0741	lytic transglycosylase activity
CEW88_13850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_13855	COG0612	Peptidase, M16
CEW88_13860	COG0612	Peptidase, M16
CEW88_13870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEW88_13890	COG0138	bifunctional purine biosynthesis protein purh
CEW88_13900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW88_13900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEW88_13915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEW88_13920	COG3698	Phosphodiester glycosidase
CEW88_13925	COG0312	modulator of DNA gyrase
CEW88_13930	COG1218	3'(2'),5'-bisphosphate nucleotidase
CEW88_13940	COG1519	Transferase
CEW88_13945	COG1663	tetraacyldisaccharide 4'-kinase activity
CEW88_13955	COG0450	alkyl hydroperoxide reductase
CEW88_13965	COG2814	Major facilitator Superfamily
CEW88_13970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEW88_13980	COG0346	lactoylglutathione lyase activity
CEW88_14005	COG1805	sodium ion transport
CEW88_14015	COG1477	protein flavinylation
CEW88_14060	COG0583	DNA-binding transcription factor activity
CEW88_14080	COG0306	phosphate transporter
CEW88_14100	COG1309	transcriptional regulator
CEW88_14120	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_14130	COG3254	rhamnose metabolic process
CEW88_14135	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_14140	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_14145	COG1129	ABC transporter
CEW88_14160	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_14160	COG3347	Dehydrogenase
CEW88_14165	COG4952	isomerase
CEW88_14170	COG1475	DNA binding
CEW88_14175	COG1192	Involved in chromosome partitioning
CEW88_14185	COG1879	ABC-type sugar transport system periplasmic component
CEW88_14190	COG1129	ABC transporter
CEW88_14195	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_14200	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_14205	COG2186	Transcriptional regulator
CEW88_14215	COG4213	ABC transporter substrate-binding protein
CEW88_14225	COG4214	carbohydrate transport
CEW88_14245	COG2017	converts alpha-aldose to the beta-anomer
CEW88_14255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_14280	COG0811	peptide transport
CEW88_14300	COG1021	2,3-dihydroxybenzoate-AMP ligase
CEW88_14310	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CEW88_14310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CEW88_14325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_14340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CEW88_14345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEW88_14365	COG0745	RESPONSE REGULATOR receiver
CEW88_14370	COG0589	response to stress
CEW88_14375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_14395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CEW88_14425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_14430	COG1335	isochorismatase
CEW88_14435	COG0251	oxidation-reduction process
CEW88_14440	COG2267	carboxylic ester hydrolase activity
CEW88_14460	COG2951	lytic endotransglycosylase activity
CEW88_14505	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW88_14510	COG3257	ureidoglycine aminohydrolase activity
CEW88_14520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEW88_14525	COG2897	thiosulfate sulfurtransferase activity
CEW88_14550	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_14555	COG0799	negative regulation of ribosome biogenesis
CEW88_14560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEW88_14565	COG1968	undecaprenyl-diphosphatase activity
CEW88_14585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEW88_14595	COG1535	isochorismatase
CEW88_14595	COG3433	isochorismatase activity
CEW88_14615	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_14620	COG2391	methyltransferase activity
CEW88_14630	COG2814	Major facilitator Superfamily
CEW88_14635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CEW88_14645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEW88_14675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEW88_14685	COG1194	a g-specific adenine glycosylase
CEW88_14700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEW88_14705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CEW88_14710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEW88_14715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEW88_14750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEW88_14755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CEW88_14775	COG2321	neutral zinc metallopeptidase
CEW88_14790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW88_14795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEW88_14795	COG0574	Belongs to the PEP-utilizing enzyme family
CEW88_14805	COG1115	amino acid carrier protein
CEW88_14810	COG1522	sequence-specific DNA binding
CEW88_14825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEW88_14850	COG0084	hydrolase, TatD family'
CEW88_14860	COG2115	Belongs to the xylose isomerase family
CEW88_14865	COG1129	ABC transporter
CEW88_14870	COG4214	carbohydrate transport
CEW88_14875	COG4213	ABC transporter substrate-binding protein
CEW88_14880	COG1846	Transcriptional regulator
CEW88_14880	COG1940	carbohydrate kinase activity
CEW88_14890	COG1858	cytochrome C peroxidase
CEW88_14900	COG0395	ABC-type sugar transport system, permease component
CEW88_14905	COG1175	transmembrane transport
CEW88_14915	COG0410	ABC transporter
CEW88_14930	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW88_14940	COG2308	Evidence 4 Homologs of previously reported genes of
CEW88_14960	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEW88_14965	COG2201	protein-glutamate methylesterase activity
CEW88_14975	COG0745	RESPONSE REGULATOR receiver
CEW88_14980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEW88_14985	COG0835	chemotaxis
CEW88_14995	COG0745	RESPONSE REGULATOR receiver
CEW88_15020	COG0133	tryptophan synthase activity
CEW88_15030	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEW88_15035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW88_15045	COG4206	TonB-dependent receptor
CEW88_15055	COG1136	(ABC) transporter
CEW88_15065	COG1785	Belongs to the alkaline phosphatase family
CEW88_15090	COG3250	beta-galactosidase activity
CEW88_15100	COG3237	CsbD-like
CEW88_15125	COG0187	DNA topoisomerase II activity
CEW88_15150	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEW88_15165	COG0346	lactoylglutathione lyase activity
CEW88_15180	COG1846	Transcriptional regulator
CEW88_15210	COG3119	arylsulfatase activity
CEW88_15215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_15225	COG0483	inositol monophosphate 1-phosphatase activity
CEW88_15240	COG0589	response to stress
CEW88_15260	COG0405	Gamma-glutamyltransferase
CEW88_15265	COG4608	Belongs to the ABC transporter superfamily
CEW88_15270	COG0444	Belongs to the ABC transporter superfamily
CEW88_15280	COG0601	transmembrane transport
CEW88_15290	COG1802	Transcriptional regulator
CEW88_15305	COG0784	Response regulator, receiver
CEW88_15315	COG3920	Histidine kinase
CEW88_15345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_15350	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_15355	COG1522	sequence-specific DNA binding
CEW88_15365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_15370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_15375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_15380	COG0589	response to stress
CEW88_15390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_15395	COG2423	ornithine cyclodeaminase activity
CEW88_15400	COG0006	proline dipeptidase activity
CEW88_15415	COG0343	queuine tRNA-ribosyltransferase activity
CEW88_15420	COG1902	pentaerythritol trinitrate reductase activity
CEW88_15425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEW88_15465	COG3750	Belongs to the UPF0335 family
CEW88_15540	COG4695	Portal protein
CEW88_15685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_15690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_15695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_15710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW88_15715	COG3842	ATPase activity
CEW88_15720	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_15725	COG1177	transmembrane transport
CEW88_15735	COG4172	Belongs to the ABC transporter superfamily
CEW88_15745	COG0747	negative chemotaxis
CEW88_15795	COG2132	Multicopper oxidase
CEW88_15800	COG2132	Multicopper oxidase
CEW88_15810	COG1034	ATP synthesis coupled electron transport
CEW88_15830	COG0395	ABC-type sugar transport system, permease component
CEW88_15835	COG0165	Argininosuccinate lyase
CEW88_15840	COG3842	ATPase activity
CEW88_15850	COG0363	glucosamine-6-phosphate deaminase activity
CEW88_15855	COG2186	Transcriptional regulator
CEW88_15870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_15875	COG0698	ribose 5-phosphate isomerase
CEW88_15890	COG0583	DNA-binding transcription factor activity
CEW88_15905	COG2086	electron transfer activity
CEW88_15915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_15930	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_15930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_15940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEW88_15960	COG0673	inositol 2-dehydrogenase activity
CEW88_15975	COG4989	oxidoreductase activity
CEW88_16005	COG0583	DNA-binding transcription factor activity
CEW88_16060	COG1473	amidohydrolase
CEW88_16065	COG0583	DNA-binding transcription factor activity
CEW88_16075	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_16090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_16150	COG0556	nucleotide-excision repair
CEW88_16180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_16225	COG3842	ATPase activity
CEW88_16235	COG1175	transmembrane transport
CEW88_16240	COG0395	ABC-type sugar transport system, permease component
CEW88_16245	COG3842	ATPase activity
CEW88_16265	COG4251	negative regulation of phosphorylation
CEW88_16275	COG0587	DNA-directed DNA polymerase activity
CEW88_16280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEW88_16290	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CEW88_16315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEW88_16325	COG0800	Aldolase
CEW88_16330	COG0129	dihydroxy-acid dehydratase activity
CEW88_16340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW88_16350	COG1320	monovalent cation:proton antiporter activity
CEW88_16355	COG2212	antiporter activity
CEW88_16365	COG0651	ATP synthesis coupled electron transport
CEW88_16370	COG1006	Multisubunit Na H antiporter MnhC subunit
CEW88_16375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW88_16375	COG2111	Na H antiporter
CEW88_16380	COG3842	ATPase activity
CEW88_16445	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_16450	COG4335	DNA alkylation repair
CEW88_16455	COG3180	Ammonia monooxygenase
CEW88_16460	COG2863	cytochrome
CEW88_16470	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_16485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW88_16490	COG0737	Belongs to the 5'-nucleotidase family
CEW88_16495	COG3258	Cytochrome c
CEW88_16520	COG0785	Cytochrome C biogenesis protein
CEW88_16535	COG2391	methyltransferase activity
CEW88_16545	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_16550	COG1177	transmembrane transport
CEW88_16555	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_16560	COG3842	ATPase activity
CEW88_16565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW88_16570	COG0583	DNA-binding transcription factor activity
CEW88_16580	COG1522	sequence-specific DNA binding
CEW88_16610	COG0583	DNA-binding transcription factor activity
CEW88_16615	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_16625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_16625	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CEW88_16635	COG1473	amidohydrolase
CEW88_16645	COG0697	spore germination
CEW88_16655	COG4191	Histidine kinase
CEW88_16675	COG1049	propionate catabolic process, 2-methylcitrate cycle
CEW88_16685	COG2080	2 iron, 2 sulfur cluster binding
CEW88_16690	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CEW88_16695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_16700	COG1132	(ABC) transporter
CEW88_16705	COG0438	transferase activity, transferring glycosyl groups
CEW88_16710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEW88_16730	COG1304	FMN binding
CEW88_16755	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CEW88_16760	COG1214	PFAM Peptidase M22, glycoprotease
CEW88_16790	COG0730	response to heat
CEW88_16825	COG1022	Amp-dependent synthetase and ligase
CEW88_16860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CEW88_16880	COG2183	response to ionizing radiation
CEW88_16885	COG2197	response regulator
CEW88_16890	COG4585	Histidine kinase
CEW88_16895	COG1879	ABC-type sugar transport system periplasmic component
CEW88_16900	COG1129	ABC transporter
CEW88_16905	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_16915	COG3386	PFAM SMP-30 Gluconolaconase
CEW88_16920	COG0693	protein deglycase activity
CEW88_16925	COG0583	DNA-binding transcription factor activity
CEW88_16930	COG1309	transcriptional regulator
CEW88_16955	COG1058	Belongs to the CinA family
CEW88_16955	COG1546	Belongs to the CinA family
CEW88_16970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_16980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_16985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_17025	COG1780	Probably involved in ribonucleotide reductase function
CEW88_17040	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CEW88_17050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_17075	COG0754	glutathionylspermidine amidase activity
CEW88_17095	COG2832	Protein of unknown function (DUF454)
CEW88_17105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_17115	COG2116	formate transmembrane transporter activity
CEW88_17120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CEW88_17125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CEW88_17135	COG3842	ATPase activity
CEW88_17145	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_17155	COG1609	Transcriptional regulator
CEW88_17160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW88_17165	COG1127	ABC transporter
CEW88_17185	COG4175	Glycine betaine
CEW88_17200	COG1309	transcriptional regulator
CEW88_17220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEW88_17225	COG2011	ABC-type metal ion transport system permease component
CEW88_17230	COG1464	Belongs to the NlpA lipoprotein family
CEW88_17240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW88_17240	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_17270	COG0281	malic enzyme
CEW88_17270	COG0280	phosphate acetyltransferase
CEW88_17280	COG1227	inorganic diphosphatase activity
CEW88_17295	COG2030	dehydratase
CEW88_17305	COG1309	transcriptional regulator
CEW88_17315	COG0730	response to heat
CEW88_17320	COG0024	Methionine aminopeptidase
CEW88_17325	COG0668	transmembrane transport
CEW88_17330	COG1489	DNA binding
CEW88_17335	COG1349	DNA-binding transcription factor activity
CEW88_17345	COG3842	ATPase activity
CEW88_17350	COG3842	ATPase activity
CEW88_17355	COG1175	transmembrane transport
CEW88_17360	COG0395	ABC-type sugar transport system, permease component
CEW88_17375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEW88_17380	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_17385	COG1177	transmembrane transport
CEW88_17390	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW88_17445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_17480	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_17500	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEW88_17520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_17535	COG0752	glycyl-tRNA synthetase alpha subunit
CEW88_17545	COG0181	hydroxymethylbilane synthase activity
CEW88_17550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEW88_17555	COG0697	spore germination
CEW88_17560	COG1131	(ABC) transporter
CEW88_17565	COG0842	Transport permease protein
CEW88_17605	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEW88_17630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEW88_17640	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_17670	COG0418	dihydroorotase activity
CEW88_17675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEW88_17690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEW88_17695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW88_17700	COG1127	ABC transporter
CEW88_17730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEW88_17740	COG4221	oxidoreductase activity
CEW88_17750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CEW88_17755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW88_17770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CEW88_17775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEW88_17780	COG1845	cytochrome c oxidase, subunit III
CEW88_17785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CEW88_17800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEW88_17810	COG0193	aminoacyl-tRNA hydrolase activity
CEW88_17845	COG1114	Component of the transport system for branched-chain amino acids
CEW88_17855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEW88_17875	COG5425	PFAM Usg family protein
CEW88_17880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEW88_17900	COG3220	belongs to the UPF0276 family
CEW88_17930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEW88_17940	COG1162	GTPase activity
CEW88_17955	COG1940	carbohydrate kinase activity
CEW88_17960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CEW88_17965	COG0673	inositol 2-dehydrogenase activity
CEW88_17970	COG1175	transmembrane transport
CEW88_17975	COG0395	ABC-type sugar transport system, permease component
CEW88_17985	COG3842	ATPase activity
CEW88_18000	COG1737	Transcriptional regulator
CEW88_18015	COG3142	Participates in the control of copper homeostasis
CEW88_18020	COG0363	glucosamine-6-phosphate deaminase activity
CEW88_18040	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CEW88_18045	COG0673	inositol 2-dehydrogenase activity
CEW88_18065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEW88_18100	COG1960	acyl-CoA dehydrogenase activity
CEW88_18105	COG0009	L-threonylcarbamoyladenylate synthase
CEW88_18110	COG1678	Uncharacterized ACR, COG1678
CEW88_18130	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEW88_18140	COG1573	uracil-dna glycosylase
CEW88_18150	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEW88_18155	COG1121	(ABC) transporter
CEW88_18160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEW88_18165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEW88_18170	COG1063	alcohol dehydrogenase
CEW88_18180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_18190	COG4166	transmembrane transport
CEW88_18195	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_18195	COG0824	Thioesterase
CEW88_18200	COG3246	L-lysine catabolic process to acetate
CEW88_18220	COG0306	phosphate transporter
CEW88_18235	COG1802	Transcriptional regulator
CEW88_18245	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW88_18270	COG3246	L-lysine catabolic process to acetate
CEW88_18275	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_18280	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_18285	COG1011	Hydrolase
CEW88_18295	COG3639	organic phosphonate transmembrane transporter activity
CEW88_18335	COG1070	Carbohydrate kinase
CEW88_18340	COG1879	ABC-type sugar transport system periplasmic component
CEW88_18345	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_18350	COG1129	ABC transporter
CEW88_18355	COG0673	inositol 2-dehydrogenase activity
CEW88_18370	COG1609	Transcriptional regulator
CEW88_18375	COG1653	transport
CEW88_18385	COG0395	ABC-type sugar transport system, permease component
CEW88_18390	COG3507	Belongs to the glycosyl hydrolase 43 family
CEW88_18400	COG0673	inositol 2-dehydrogenase activity
CEW88_18475	COG0154	amidase activity
CEW88_18480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_18485	COG4172	Belongs to the ABC transporter superfamily
CEW88_18495	COG0601	transmembrane transport
CEW88_18500	COG0747	negative chemotaxis
CEW88_18505	COG0235	Class ii aldolase
CEW88_18520	COG0789	Transcriptional regulator
CEW88_18545	COG0662	Cupin 2, conserved barrel domain protein
CEW88_18625	COG0662	Cupin 2, conserved barrel domain protein
CEW88_18625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CEW88_18670	COG1971	Probably functions as a manganese efflux pump
CEW88_18680	COG3436	PFAM IS66 Orf2 family protein
CEW88_18700	COG0583	DNA-binding transcription factor activity
CEW88_18715	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_18740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW88_18745	COG0477	Major facilitator Superfamily
CEW88_18750	COG1959	2 iron, 2 sulfur cluster binding
CEW88_18755	COG3119	arylsulfatase activity
CEW88_18800	COG0444	Belongs to the ABC transporter superfamily
CEW88_18815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_18835	COG0583	DNA-binding transcription factor activity
CEW88_18840	COG0747	negative chemotaxis
CEW88_18845	COG0210	DNA helicase
CEW88_18860	COG0420	3'-5' exonuclease activity
CEW88_18870	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CEW88_18890	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_18895	COG1733	regulation of RNA biosynthetic process
CEW88_18970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW88_19060	COG1414	Transcriptional regulator
CEW88_19085	COG1506	peptidase
CEW88_19090	COG0747	negative chemotaxis
CEW88_19115	COG0444	Belongs to the ABC transporter superfamily
CEW88_19125	COG0601	transmembrane transport
CEW88_19130	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_19145	COG1063	alcohol dehydrogenase
CEW88_19195	COG0601	transmembrane transport
CEW88_19200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_19205	COG0445	tRNA wobble uridine modification
CEW88_19215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW88_19230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW88_19240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_19250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW88_19260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_19265	COG1522	sequence-specific DNA binding
CEW88_19270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_19275	COG0473	3-isopropylmalate dehydrogenase activity
CEW88_19280	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_19290	COG1802	Transcriptional regulator
CEW88_19295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_19325	COG4154	Belongs to the RbsD FucU family
CEW88_19340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEW88_19345	COG0667	Aldo Keto reductase
CEW88_19355	COG2376	Dihydroxyacetone kinase
CEW88_19365	COG1129	ABC transporter
CEW88_19380	COG1609	Transcriptional regulator
CEW88_19385	COG1609	Transcriptional regulator
CEW88_19410	COG0673	inositol 2-dehydrogenase activity
CEW88_19430	COG1566	PFAM secretion protein HlyD family protein
CEW88_19435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_19440	COG0745	RESPONSE REGULATOR receiver
CEW88_19445	COG2205	protein histidine kinase activity
CEW88_19450	COG1132	(ABC) transporter
CEW88_19460	COG1053	succinate dehydrogenase
CEW88_19465	COG1802	Transcriptional regulator
CEW88_19475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_19485	COG2828	Protein conserved in bacteria
CEW88_19505	COG2205	protein histidine kinase activity
CEW88_19520	COG0583	DNA-binding transcription factor activity
CEW88_19525	COG2433	Pfam Transposase IS66
CEW88_19550	COG1271	oxidase subunit
CEW88_19555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_19560	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_19565	COG0156	8-amino-7-oxononanoate synthase activity
CEW88_19575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW88_19600	COG2144	transferase activity, transferring acyl groups
CEW88_19610	COG2072	flavoprotein involved in K transport
CEW88_19625	COG0583	DNA-binding transcription factor activity
CEW88_19630	COG0346	lactoylglutathione lyase activity
CEW88_19635	COG0400	carboxylic ester hydrolase activity
CEW88_19640	COG2388	GCN5-related N-acetyl-transferase
CEW88_19645	COG1741	Belongs to the pirin family
CEW88_19650	COG2205	protein histidine kinase activity
CEW88_19665	COG2223	nitrite transmembrane transporter activity
CEW88_19685	COG1215	transferase activity, transferring glycosyl groups
CEW88_19720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW88_19725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW88_19740	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW88_19750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW88_19750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW88_19780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CEW88_19810	COG1446	asparaginase
CEW88_19825	COG0747	negative chemotaxis
CEW88_19850	COG0601	transmembrane transport
CEW88_19855	COG2197	response regulator
CEW88_19875	COG2197	response regulator
CEW88_19880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW88_19895	COG1215	transferase activity, transferring glycosyl groups
CEW88_19900	COG1216	Glycosyl transferase, family 2
CEW88_19905	COG0438	transferase activity, transferring glycosyl groups
CEW88_19915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_19945	COG3038	cytochrome b561
CEW88_19950	COG0583	DNA-binding transcription factor activity
CEW88_19955	COG2080	2 iron, 2 sulfur cluster binding
CEW88_19960	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_19975	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_19980	COG3257	ureidoglycine aminohydrolase activity
CEW88_19985	COG1414	Transcriptional regulator
CEW88_20015	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW88_20025	COG0583	DNA-binding transcription factor activity
CEW88_20035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_20050	COG0726	polysaccharide deacetylase
CEW88_20055	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_20075	COG0747	negative chemotaxis
CEW88_20080	COG0601	transmembrane transport
CEW88_20085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_20090	COG0444	Belongs to the ABC transporter superfamily
CEW88_20095	COG4608	Belongs to the ABC transporter superfamily
CEW88_20100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEW88_20110	COG1309	transcriptional regulator
CEW88_20120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_20125	COG4215	(ABC) transporter
CEW88_20135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_20145	COG0235	Class ii aldolase
CEW88_20150	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_20150	COG0824	Thioesterase
CEW88_20155	COG3246	L-lysine catabolic process to acetate
CEW88_20170	COG1960	acyl-CoA dehydrogenase activity
CEW88_20185	COG3347	Dehydrogenase
CEW88_20185	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_20190	COG1879	ABC-type sugar transport system periplasmic component
CEW88_20200	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_20205	COG1129	ABC transporter
CEW88_20210	COG2390	Transcriptional regulator
CEW88_20225	COG1126	abc transporter atp-binding protein
CEW88_20240	COG0583	DNA-binding transcription factor activity
CEW88_20245	COG2814	Major facilitator Superfamily
CEW88_20250	COG2186	Transcriptional regulator
CEW88_20275	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_20280	COG1063	alcohol dehydrogenase
CEW88_20300	COG1733	regulation of RNA biosynthetic process
CEW88_20305	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_20325	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW88_20325	COG1902	pentaerythritol trinitrate reductase activity
CEW88_20340	COG1733	regulation of RNA biosynthetic process
CEW88_20360	COG1131	(ABC) transporter
CEW88_20365	COG0842	Transport permease protein
CEW88_20370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW88_20375	COG2233	PERMEase
CEW88_20390	COG1309	transcriptional regulator
CEW88_20395	COG2249	NAD(P)H dehydrogenase (quinone) activity
CEW88_20400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_20415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_20440	COG1132	(ABC) transporter
CEW88_20455	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_20475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_20480	COG1338	Plays a role in the flagellum-specific transport system
CEW88_20485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW88_20495	COG5443	negative regulation of bacterial-type flagellum assembly
CEW88_20505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEW88_20520	COG1706	bacterial-type flagellum-dependent cell motility
CEW88_20550	COG4786	Flagellar basal body rod
CEW88_20555	COG4786	Flagellar basal body rod
CEW88_20565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEW88_20585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW88_20595	COG1360	Flagellar Motor Protein
CEW88_20620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEW88_20645	COG2936	dipeptidyl-peptidase activity
CEW88_20660	COG0601	transmembrane transport
CEW88_20670	COG0583	DNA-binding transcription factor activity
CEW88_20675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW88_20675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW88_20685	COG0246	Mannitol dehydrogenase
CEW88_20690	COG1312	Catalyzes the dehydration of D-mannonate
CEW88_20695	COG1802	Transcriptional regulator
CEW88_20700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_20710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_20715	COG1063	alcohol dehydrogenase
CEW88_20725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEW88_20730	COG3485	protocatechuate 3,4-dioxygenase
CEW88_20735	COG3485	protocatechuate 3,4-dioxygenase
CEW88_20745	COG0596	Alpha beta hydrolase
CEW88_20750	COG0583	DNA-binding transcription factor activity
CEW88_20755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW88_20765	COG0456	acetyltransferase
CEW88_20770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CEW88_20775	COG1917	Cupin 2, conserved barrel domain protein
CEW88_20780	COG0527	aspartate kinase activity
CEW88_20785	COG0019	diaminopimelate decarboxylase activity
CEW88_20800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEW88_20810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW88_20815	COG1305	Transglutaminase-like
CEW88_20820	COG0025	NhaP-type Na H and K H
CEW88_20830	COG1192	Involved in chromosome partitioning
CEW88_20850	COG1157	protein secretion by the type III secretion system
CEW88_20855	COG1815	bacterial-type flagellum-dependent cell motility
CEW88_20860	COG1558	bacterial-type flagellum-dependent cell motility
CEW88_20865	COG1677	Flagellar hook-basal body complex protein FliE
CEW88_20870	COG1987	bacterial-type flagellum assembly
CEW88_20880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW88_20885	COG1684	flagellar biosynthetic protein fliR
CEW88_20890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW88_20920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW88_20925	COG1178	ABC-type Fe3 transport system permease component
CEW88_20930	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW88_20935	COG3842	ATPase activity
CEW88_20940	COG2351	hydroxyisourate hydrolase activity
CEW88_20965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW88_20985	COG2204	response regulator
CEW88_20995	COG2864	formate dehydrogenase
CEW88_21000	COG0437	4 iron, 4 sulfur cluster binding
CEW88_21005	COG0243	molybdopterin cofactor binding
CEW88_21005	COG3383	formate dehydrogenase (NAD+) activity
CEW88_21040	COG0489	protein tyrosine kinase activity
CEW88_21055	COG3852	Histidine kinase
CEW88_21060	COG3383	formate dehydrogenase (NAD+) activity
CEW88_21070	COG0425	Belongs to the sulfur carrier protein TusA family
CEW88_21075	COG0303	'Molybdopterin
CEW88_21080	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEW88_21085	COG0746	molybdenum cofactor guanylyltransferase activity
CEW88_21110	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_21115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW88_21120	COG3246	L-lysine catabolic process to acetate
CEW88_21125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW88_21135	COG4993	Dehydrogenase
CEW88_21145	COG2205	protein histidine kinase activity
CEW88_21165	COG0395	ABC-type sugar transport system, permease component
CEW88_21170	COG3842	ATPase activity
CEW88_21185	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_21190	COG0583	DNA-binding transcription factor activity
CEW88_21200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CEW88_21205	COG4208	sulfate ABC transporter
CEW88_21215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CEW88_21220	COG1959	2 iron, 2 sulfur cluster binding
CEW88_21225	COG1522	sequence-specific DNA binding
CEW88_21245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_21260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CEW88_21265	COG0243	molybdopterin cofactor binding
CEW88_21270	COG1271	oxidase subunit
CEW88_21275	COG1294	oxidase, subunit
CEW88_21280	COG0655	NAD(P)H dehydrogenase (quinone) activity
CEW88_21290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEW88_21330	COG2873	o-acetylhomoserine
CEW88_21355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW88_21360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW88_21365	COG0583	DNA-binding transcription factor activity
CEW88_21370	COG0246	Mannitol dehydrogenase
CEW88_21395	COG0633	Ferredoxin
CEW88_21415	COG1609	Transcriptional regulator
CEW88_21440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_21445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW88_21450	COG1522	sequence-specific DNA binding
CEW88_21455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEW88_21460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CEW88_21465	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CEW88_21485	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CEW88_21535	COG2099	Precorrin-6x reductase
CEW88_21550	COG2875	Belongs to the precorrin methyltransferase family
CEW88_21555	COG1797	cobyrinic acid a,c-diamide synthase activity
CEW88_21580	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_21595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_21630	COG0765	amino acid transport
CEW88_21635	COG0765	amino acid transport
CEW88_21645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEW88_21665	COG3938	Belongs to the proline racemase family
CEW88_21670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_21675	COG3938	Belongs to the proline racemase family
CEW88_21740	COG1116	anion transmembrane transporter activity
CEW88_21800	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CEW88_21870	COG1414	Transcriptional regulator
CEW88_21875	COG1475	DNA binding
CEW88_21880	COG1192	Involved in chromosome partitioning
CEW88_21885	COG0535	radical SAM domain protein
CEW88_21890	COG0535	radical SAM domain protein
CEW88_21895	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CEW88_21900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CEW88_21910	COG0745	RESPONSE REGULATOR receiver
CEW88_21930	COG1131	(ABC) transporter
CEW88_21940	COG0583	DNA-binding transcription factor activity
CEW88_21950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW88_21955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW88_22000	COG1473	amidohydrolase
CEW88_22040	COG1755	Isoprenylcysteine carboxyl methyltransferase
CEW88_22045	COG3424	synthase
CEW88_22050	COG4529	Protein conserved in bacteria
CEW88_22065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_22070	COG1116	anion transmembrane transporter activity
CEW88_22090	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CEW88_22105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW88_22115	COG0625	glutathione transferase activity
CEW88_22135	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_22145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW88_22155	COG1902	pentaerythritol trinitrate reductase activity
CEW88_22160	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_22170	COG0251	oxidation-reduction process
CEW88_22190	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW88_22200	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW88_22210	COG1846	Transcriptional regulator
CEW88_22230	COG0747	negative chemotaxis
CEW88_22235	COG0601	transmembrane transport
CEW88_22240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_22245	COG0444	Belongs to the ABC transporter superfamily
CEW88_22270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_22285	COG0243	molybdopterin cofactor binding
CEW88_22290	COG0437	4 iron, 4 sulfur cluster binding
CEW88_22295	COG0348	domain, Protein
CEW88_22380	COG0489	protein tyrosine kinase activity
CEW88_22415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CEW88_22415	COG0392	lysyltransferase activity
CEW88_22425	COG0671	phosphoesterase, PA-phosphatase related
CEW88_22435	COG0477	Major facilitator Superfamily
CEW88_22440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_22445	COG1116	anion transmembrane transporter activity
CEW88_22450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CEW88_22455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW88_22460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEW88_22470	COG2022	thiamine diphosphate biosynthetic process
CEW88_22485	COG0351	phosphomethylpyrimidine kinase
CEW88_22490	COG1522	sequence-specific DNA binding
CEW88_22495	COG3483	tryptophan 2,3-dioxygenase activity
CEW88_22500	COG1126	abc transporter atp-binding protein
CEW88_22510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_22515	COG0765	amino acid transport
CEW88_22520	COG3844	kynureninase activity
CEW88_22525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW88_22530	COG1126	abc transporter atp-binding protein
CEW88_22535	COG0765	amino acid transport
CEW88_22560	COG2826	transposase and inactivated derivatives, IS30 family
CEW88_22570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW88_22575	COG2186	Transcriptional regulator
CEW88_22580	COG0747	negative chemotaxis
CEW88_22590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW88_22595	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_22600	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_22605	COG0444	Belongs to the ABC transporter superfamily
CEW88_22610	COG4608	Belongs to the ABC transporter superfamily
CEW88_22615	COG0590	tRNA wobble adenosine to inosine editing
CEW88_22640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_22660	COG0583	DNA-binding transcription factor activity
CEW88_22680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEW88_22685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEW88_22690	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_22720	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_22720	COG1024	Enoyl-CoA hydratase
CEW88_22755	COG1024	Enoyl-CoA hydratase
CEW88_22760	COG2050	protein possibly involved in aromatic compounds catabolism
CEW88_22770	COG1309	transcriptional regulator
CEW88_22780	COG2030	dehydratase
CEW88_22780	COG1012	belongs to the aldehyde dehydrogenase family
CEW88_22790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW88_22795	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW88_22800	COG3396	Phenylacetate-CoA oxygenase
CEW88_22805	COG3460	Phenylacetate-CoA oxygenase
CEW88_22810	COG3396	Phenylacetate-CoA oxygenase
CEW88_22815	COG0183	Belongs to the thiolase family
CEW88_22820	COG3327	negative regulation of DNA-templated transcription, initiation
CEW88_22830	COG1522	sequence-specific DNA binding
CEW88_22845	COG0569	domain protein
CEW88_22850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEW88_22855	COG3842	ATPase activity
CEW88_22860	COG0395	ABC-type sugar transport system, permease component
CEW88_22865	COG1175	transmembrane transport
CEW88_22870	COG2182	Extracellular solute-binding protein
CEW88_22885	COG1609	Transcriptional regulator
CEW88_22890	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEW88_22895	COG1129	ABC transporter
CEW88_22930	COG0583	DNA-binding transcription factor activity
CEW88_22945	COG3842	ATPase activity
CEW88_22955	COG0395	ABC-type sugar transport system, permease component
CEW88_22970	COG1609	Transcriptional regulator
CEW88_22975	COG0625	glutathione transferase activity
CEW88_22985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW88_23015	COG0667	Aldo Keto reductase
CEW88_23025	COG1802	Transcriptional regulator
CEW88_23040	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW88_23065	COG2067	long-chain fatty acid transport protein
CEW88_23070	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_23075	COG0789	Transcriptional regulator
CEW88_23080	COG0183	Belongs to the thiolase family
CEW88_23085	COG1024	Enoyl-CoA hydratase
CEW88_23085	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW88_23090	COG1960	acyl-CoA dehydrogenase activity
CEW88_23095	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_23110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEW88_23115	COG1126	abc transporter atp-binding protein
CEW88_23125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW88_23130	COG2186	Transcriptional regulator
CEW88_23145	COG0640	Transcriptional regulator
CEW88_23150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEW88_23155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW88_23170	COG1802	Transcriptional regulator
CEW88_23175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW88_23195	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_23200	COG1024	Enoyl-CoA hydratase
CEW88_23205	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_23230	COG1366	Belongs to the anti-sigma-factor antagonist family
CEW88_23235	COG1366	Belongs to the anti-sigma-factor antagonist family
CEW88_23240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW88_23245	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CEW88_23250	COG2080	2 iron, 2 sulfur cluster binding
CEW88_23265	COG0640	Transcriptional regulator
CEW88_23285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW88_23325	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_23335	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEW88_23345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW88_23350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW88_23360	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_23365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_23370	COG0471	metal ion transport
CEW88_23375	COG4948	Mandelate Racemase Muconate Lactonizing
CEW88_23385	COG0596	Alpha beta hydrolase
CEW88_23390	COG0583	DNA-binding transcription factor activity
CEW88_23410	COG0489	protein tyrosine kinase activity
CEW88_23410	COG3206	protein involved in exopolysaccharide biosynthesis
CEW88_23430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW88_23450	COG1216	Glycosyl transferase, family 2
CEW88_23450	COG1442	glycosyl transferase family 8
CEW88_23470	COG0667	Aldo Keto reductase
CEW88_23480	COG0673	inositol 2-dehydrogenase activity
CEW88_23505	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW88_23515	COG0175	sulfate reduction
CEW88_23550	COG1192	Involved in chromosome partitioning
CEW88_23640	COG3562	capsule polysaccharide
CEW88_23680	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CEW88_23685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CEW88_23695	COG0517	IMP dehydrogenase activity
CEW88_23695	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEW88_23700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW88_23705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW88_23785	COG2244	polysaccharide biosynthetic process
CEW88_23790	COG2327	Polysaccharide pyruvyl transferase
CEW88_23820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEW88_23835	COG1216	Glycosyl transferase, family 2
CEW88_23840	COG0463	Glycosyl transferase, family 2
CEW88_23845	COG0251	oxidation-reduction process
CEW88_23850	COG0747	negative chemotaxis
CEW88_23855	COG0601	transmembrane transport
CEW88_23865	COG0444	Belongs to the ABC transporter superfamily
CEW88_23870	COG4608	Belongs to the ABC transporter superfamily
CEW88_23895	COG0765	amino acid transport
CEW88_23920	COG0210	DNA helicase
CEW88_23925	COG0318	PFAM AMP-dependent synthetase and ligase
CEW88_23930	COG0183	Belongs to the thiolase family
CEW88_23940	COG1268	BioY protein
CEW88_23945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CEW88_23950	COG1122	ATPase activity
CEW88_23965	COG2124	cytochrome p450
CEW88_23965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEW88_24020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW88_24040	COG0402	S-adenosylhomocysteine deaminase activity
CEW88_24060	COG1028	Short-chain dehydrogenase reductase Sdr
CEW88_24075	COG1268	BioY protein
CEW88_24080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEW88_24105	COG1278	Cold shock
CEW88_24175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEW88_24205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW88_24225	COG1652	LysM domain
CEW88_24250	COG3104	oligopeptide transport
CEW88_24260	COG1192	Involved in chromosome partitioning
CEW88_24280	COG2814	Major facilitator Superfamily
CEW88_24295	COG0110	maltose O-acetyltransferase activity