locus-tag class description ACZ76_00020 ENOG4105K4U addiction module toxin, RelE StbE family ACZ76_00080 ENOG4105HRS Antitermination protein ACZ76_00085 ENOG4105RWQ Protein of unknown function (DUF1364) ACZ76_00140 ENOG41087BU transcriptional repressor DicA ACZ76_00175 ENOG4108I1J Integrase ACZ76_00180 ENOG4105NKT exported protein ACZ76_00185 ENOG4108PNC copper resistance ACZ76_00190 ENOG4105FXM Copper resistance protein ACZ76_00195 ENOG41090A1 ferritin ACZ76_00200 ENOG4105MPK DNA polymerase III subunit theta ACZ76_00210 ENOG4105UMD exodeoxyribonuclease X ACZ76_00215 ENOG4105CUG Oligopeptidase b ACZ76_00225 ENOG4105N5Z UPF0267 protein ACZ76_00230 ENOG4105X2V dna damage-inducible protein ACZ76_00235 ENOG4105C1J atp-dependent rna helicase ACZ76_00240 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ACZ76_00245 ENOG4105X5C UPF0181 protein ACZ76_00255 ENOG4105P8F nudix hydrolase ACZ76_00260 ENOG4105EJQ L-serine dehydratase ACZ76_00265 ENOG4105EE5 Membrane protein terC ACZ76_00270 ENOG4108EQA pts system ACZ76_00275 ENOG4105ETZ PTS System ACZ76_00280 ENOG4105F3R pts system mannose fructose sorbose family iid ACZ76_00285 ENOG4108NK4 UPF0266 membrane protein ACZ76_00290 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) ACZ76_00300 ENOG4105BZU Histidine kinase ACZ76_00310 ENOG4105DHI Methyltransferase ACZ76_00315 ENOG4105CJN penicillin-binding protein ACZ76_00320 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ACZ76_00325 ENOG4105VEQ Cold shock protein ACZ76_00330 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) ACZ76_00335 ENOG4105C85 amino acid ACZ76_00350 ENOG41064PC ACZ76_00355 ENOG4105TIK ACZ76_00360 ENOG4105N4N Protein of unknown function (DUF2766) ACZ76_00380 ENOG4105D5Q Arginine ornithine antiporter ACZ76_00390 ENOG4105BZ1 (ABC) transporter ACZ76_00410 ENOG4105XXV Acid-resistance protein ACZ76_00415 ENOG4105VTN Protein of unknown function (DUF1311) ACZ76_00425 ENOG4105DWP Membrane ACZ76_00430 ENOG4105KVH Transcriptional regulator ACZ76_00435 ENOG4105ECR NmrA family ACZ76_00440 ENOG4108IQK o-acetylhomoserine ACZ76_00445 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ACZ76_00465 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACZ76_00520 ENOG4105DFE Dna adenine methylase ACZ76_00530 ENOG4105VZ1 Replication Protein ACZ76_00545 ENOG4105C4R Atp-dependent dna helicase ACZ76_00560 ENOG4105ED4 portal protein ACZ76_00650 ENOG4108X9F tail fiber protein ACZ76_00695 ENOG4105ZTC transcriptional activator, Ogr delta ACZ76_00715 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ACZ76_00720 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ACZ76_00725 ENOG4105WH1 Two component transcriptional regulator luxr family ACZ76_00730 ENOG4105XVG cytoplasmic protein ACZ76_00735 ENOG4105RA2 Membrane ACZ76_00745 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_00750 ENOG4105E5K Alpha-amylase ACZ76_00765 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ACZ76_00780 ENOG4108R86 Transcriptional regulator ACZ76_00785 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) ACZ76_00790 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) ACZ76_00795 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) ACZ76_00800 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ACZ76_00805 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) ACZ76_00810 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) ACZ76_00815 ENOG4105C2W permease ACZ76_00835 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) ACZ76_00865 ENOG4105CK7 Sodium proline symporter ACZ76_00870 ENOG4105C26 Dehydrogenase ACZ76_00885 ENOG4105CDA abc transporter atp-binding protein ACZ76_00890 ENOG4105E5Q amino acid AbC transporter ACZ76_00895 ENOG4105EAB amino acid AbC transporter ACZ76_00900 ENOG4105K6H D-cysteine desulfhydrase ACZ76_00905 ENOG4108M9K flagella biosynthesis protein FliZ ACZ76_00910 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACZ76_00915 ENOG4108C80 FliB family ACZ76_00925 ENOG4105DTS flagellar hook-associated ACZ76_00930 ENOG4105MQ3 flagellar protein FliS ACZ76_00935 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) ACZ76_00945 ENOG4105DHT Metal Dependent Phosphohydrolase ACZ76_00955 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ACZ76_00960 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ACZ76_00965 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ACZ76_00970 ENOG41090PJ Flagellar assembly protein ACZ76_00975 ENOG4108JIR Flagellum-specific ATP synthase ACZ76_00980 ENOG4105GSA Flagellar export protein flij ACZ76_00985 ENOG4105WF4 Flagellar hook-length control protein ACZ76_00990 ENOG4107ZI8 flagellar basal body-associated protein flil ACZ76_00995 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ACZ76_01000 ENOG4105DD5 Flagellar motor switch protein ACZ76_01010 ENOG4105CN7 Flagellar biosynthetic protein FliP ACZ76_01015 ENOG4105VS8 Flagellar biosynthetic protein fliq ACZ76_01020 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ACZ76_01025 ENOG4105DTJ flagellar hook-associated protein ACZ76_01030 ENOG4105E1Q flagellar hook-associated protein ACZ76_01035 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ACZ76_01050 ENOG4105CGA flagellar basal-body rod protein FlgG ACZ76_01055 ENOG4108KPB Flagellar basal-body rod protein FlgF ACZ76_01060 ENOG4105BZE flagellar hook protein, FlgE ACZ76_01065 ENOG4105W00 Flagellar hook capping protein ACZ76_01070 ENOG4108ZC9 flagellar basal-body rod protein flgc ACZ76_01075 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ACZ76_01080 ENOG4105CKS Flagella basal body P-ring formation protein flgA ACZ76_01085 ENOG4105M9M anti-sigma28 factor FlgM ACZ76_01090 ENOG4105QVD Flagella synthesis protein FlgN ACZ76_01095 ENOG4105W13 flagellar protein ACZ76_01100 ENOG4105D7B Flagellar biosynthesis protein flha ACZ76_01105 ENOG4105D00 flagellar biosynthetic protein flhB ACZ76_01110 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ACZ76_01115 ENOG4108VYJ response regulator receiver protein ACZ76_01125 ENOG4105BZU Histidine kinase ACZ76_01130 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_01135 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_01140 ENOG4108V3W Chemotaxis protein, CheW ACZ76_01145 ENOG4105CBS Chea signal transduction histidine kinase ACZ76_01150 ENOG4105ER2 Ompa motb domain protein ACZ76_01155 ENOG4107RD7 Flagellar Motor Protein, MotA ACZ76_01160 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region ACZ76_01165 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) ACZ76_01170 ENOG4108VA4 Universal stress protein ACZ76_01175 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ACZ76_01180 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ACZ76_01185 ENOG4105KT7 mgtC SapB transporter ACZ76_01190 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_01195 ENOG4105VZF DsrB protein ACZ76_01200 ENOG4105VEQ Cold shock protein ACZ76_01210 ENOG4105ETE Transcriptional regulator (LacI family ACZ76_01215 ENOG4105CNT hydrolase family 2 ACZ76_01225 ENOG4105GSJ Inner membrane protein ylaC ACZ76_01230 ENOG4105J0Q Transcriptional regulator ACZ76_01240 ENOG41061EV selenium-binding protein YdfZ ACZ76_01245 ENOG4105D6F Phosphatase ACZ76_01250 ENOG4108VEV chaperone ACZ76_01265 ENOG4105GQR Chaperone ACZ76_01275 ENOG4108S1B Periplasmic chaperone protein ACZ76_01280 ENOG4108D1K outer membrane usher protein ACZ76_01295 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) ACZ76_01305 ENOG4105HVQ Regulatory factor of maltose metabolism ACZ76_01315 ENOG4108TSE Transferase ACZ76_01320 ENOG4107QPK )-transporter ACZ76_01325 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ACZ76_01335 ENOG4105CHY citrate lyase, alpha ACZ76_01340 ENOG4105CI0 Citrate lyase ACZ76_01345 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) ACZ76_01350 ENOG4105DUA (citrate (pro-3S)-lyase ligase ACZ76_01355 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ACZ76_01360 ENOG4106YYS transcriptional regulatory protein ACZ76_01365 ENOG4108KX4 response regulator ACZ76_01370 ENOG4105BZU Histidine kinase ACZ76_01375 ENOG4105CXY transporter ACZ76_01380 ENOG4105C4Y ABC transporter ACZ76_01385 ENOG4107RCV ABC transporter, permease ACZ76_01390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACZ76_01400 ENOG4108Q9V regulatoR ACZ76_01405 ENOG4105BZU Histidine kinase ACZ76_01415 ENOG4105GQR Chaperone ACZ76_01420 ENOG4105CW0 outer membrane usher protein ACZ76_01430 ENOG4108VCD Chaperone ACZ76_01435 ENOG4105FE9 pseudouridine synthase ACZ76_01460 ENOG4105D3G Pseudouridine synthase ACZ76_01465 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme ACZ76_01485 ENOG4105EMU Dehydrogenase ACZ76_01490 ENOG4107R88 Chemotaxis protein (CheV) ACZ76_01495 ENOG410642W LysR family Transcriptional regulator ACZ76_01500 ENOG4107S1E Beta-lactamase ACZ76_01510 ENOG4105E98 transcriptional regulator DeoR family ACZ76_01515 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ACZ76_01525 ENOG4105UQX Mate efflux family protein ACZ76_01530 ENOG4105CDH Citrulline--aspartate ligase ACZ76_01540 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ACZ76_01545 ENOG4108TGR phosphatase ACZ76_01550 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) ACZ76_01555 ENOG4108YZT Adenosylcobinamide kinase ACZ76_01560 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ACZ76_01570 ENOG4108V4M Cobalt abc transporter ACZ76_01580 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) ACZ76_01585 ENOG4105DVK Precorrin-2 c20-methyltransferase ACZ76_01590 ENOG4107PPM cobalt chelatase ACZ76_01595 ENOG4105QUC reductase ACZ76_01600 ENOG4105E4R Precorrin-3B C17-methyltransferase ACZ76_01605 ENOG4108P62 biosynthesis protein (CbiG) ACZ76_01610 ENOG4105CIA precorrin-4 C(11)-methyltransferase ACZ76_01615 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase ACZ76_01620 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase ACZ76_01625 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) ACZ76_01630 ENOG41081F0 Precorrin-8x methylmutase ACZ76_01635 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) ACZ76_01640 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) ACZ76_01645 ENOG4107XVH Transcriptional regulator ACZ76_01650 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ACZ76_01655 ENOG4105KNY Microcompartments protein ACZ76_01660 ENOG4105EHR propanediol utilization protein pduB ACZ76_01665 ENOG4105DMB glycerol dehydratase ACZ76_01670 ENOG4105YCI dehydratase medium subunit ACZ76_01675 ENOG4108ZFT Dehydratase small subunit ACZ76_01680 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit ACZ76_01690 ENOG4105KNY Microcompartments protein ACZ76_01695 ENOG4105KNY Microcompartments protein ACZ76_01700 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) ACZ76_01710 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml ACZ76_01720 ENOG4108EKI Dehydrogenase ACZ76_01730 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) ACZ76_01740 ENOG4105M3W utilization protein ACZ76_01745 ENOG4105KTW ethanolamine utilization protein ACZ76_01750 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ACZ76_01755 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ACZ76_01760 ENOG4107QZB decarboxylase ACZ76_01765 ENOG4105JZC GHMP kinase ACZ76_01770 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ACZ76_01775 ENOG4105C2J ABC transporter ACZ76_01780 ENOG4105CNN ABC, transporter ACZ76_01790 ENOG41090HJ UPF0265 protein ACZ76_01795 ENOG4105DR8 Membrane ACZ76_01805 ENOG4105CJB Exodeoxyribonuclease I ACZ76_01810 ENOG4105CUB amino acid ACZ76_01815 ENOG4107SCQ Iron-containing alcohol dehydrogenase ACZ76_01820 ENOG4105C2J ABC transporter ACZ76_01825 ENOG4105CNN ABC, transporter ACZ76_01830 ENOG4108535 NAD dependent epimerase/dehydratase family ACZ76_01835 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ACZ76_01840 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ACZ76_01845 ENOG4105CIH Imidazole acetol-phosphate transaminase ACZ76_01850 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ACZ76_01855 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ACZ76_01860 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ACZ76_01865 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ACZ76_01870 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ACZ76_01875 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ACZ76_01880 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ACZ76_01885 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ACZ76_01900 ENOG4108DMA Nad-dependent epimerase dehydratase ACZ76_01905 ENOG4105C0K Gdp-mannose 4,6-dehydratase ACZ76_01920 ENOG4105EY8 ABC transporter ACZ76_01935 ENOG4105EE5 Membrane protein terC ACZ76_01940 ENOG4105CEE C4-dicarboxylate transporter ACZ76_01945 ENOG4108GAE asmA family ACZ76_01955 ENOG4105DBI uridine monophosphokinase ACZ76_01960 ENOG4105D1F ATP-binding protein ACZ76_01965 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ACZ76_01980 ENOG4105E5W Transporter ACZ76_01985 ENOG4105VAW lrga family ACZ76_01990 ENOG41067MG lrgb family ACZ76_02000 ENOG4107R1I NAD-dependent malic enzyme ACZ76_02005 ENOG4107GZ4 SanA protein ACZ76_02015 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ACZ76_02020 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) ACZ76_02025 ENOG4108JPZ Monovalent cation H antiporter subunit D ACZ76_02030 ENOG4107TDF Formate hydrogenlyase subunit 4 ACZ76_02035 ENOG4105D65 subunit l ACZ76_02040 ENOG4107WQX hydrogenase 4 membrane subunit ACZ76_02045 ENOG4108JPZ Monovalent cation H antiporter subunit D ACZ76_02050 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACZ76_02060 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit ACZ76_02065 ENOG4105I6X formate hydrogenlyase maturation ACZ76_02070 ENOG4108MG9 hydrogenase 3 maturation protease ACZ76_02075 ENOG4108RC0 Electron transport protein ACZ76_02080 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACZ76_02085 ENOG4108JUA Transcriptional regulator ACZ76_02090 ENOG4105TMB Formate nitrite transporter ACZ76_02095 ENOG4107SDZ Galactoside transport system permease protein mglC ACZ76_02110 ENOG41060NJ transcriptional regulator ACZ76_02115 ENOG4105DHF Membrane ACZ76_02120 ENOG4105EUJ GTP cyclohydrolase i ACZ76_02125 ENOG4105CBP Major Facilitator ACZ76_02130 ENOG4105EGI Transcriptional regulator ACZ76_02165 ENOG4105CSH Transporter ACZ76_02175 ENOG4105CVM Molybdenum cofactor synthesis domain protein ACZ76_02180 ENOG4105D06 uba thif-type nad fad binding protein ACZ76_02185 ENOG4105C5H ABC transporter ACZ76_02205 ENOG4108T1M outer membrane protein x ACZ76_02235 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) ACZ76_02240 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction ACZ76_02245 ENOG4105KSC Transcriptional regulator, TraR DksA family ACZ76_02250 ENOG4107R0W ABC transporter ACZ76_02255 ENOG4105E5Q amino acid AbC transporter ACZ76_02260 ENOG4105CDA abc transporter atp-binding protein ACZ76_02265 ENOG4107SDU Methyl-accepting chemotaxis ACZ76_02270 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) ACZ76_02275 ENOG4105EW6 flavin reductase domain protein, FMN-binding ACZ76_02280 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction ACZ76_02290 ENOG4108MTB glycosyl transferase family ACZ76_02295 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ACZ76_02300 ENOG4105DVT helicase ACZ76_02315 ENOG4105FDR Membrane ACZ76_02325 ENOG4105CXN decarboxylase ACZ76_02330 ENOG4105D5Q Arginine ornithine antiporter ACZ76_02340 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component ACZ76_02345 ENOG4108IJ8 ABC transporter ACZ76_02350 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component ACZ76_02355 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system ACZ76_02370 ENOG4105KHC sulfurtransferase ACZ76_02375 ENOG4108IV0 ABC, transporter ACZ76_02380 ENOG4105D5T phosphonate abc transporter ACZ76_02385 ENOG4105CNN ABC, transporter ACZ76_02390 ENOG4105C32 Amino acid ABC transporter (Permease) ACZ76_02395 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein ACZ76_02400 ENOG4108W15 Protein of unknown function (DUF1456) ACZ76_02415 ENOG4105EHI Phosphonate ABC transporter, periplasmic ACZ76_02425 ENOG4105Y3U Transglycosylase-associated protein ACZ76_02435 ENOG4105N1F Hnh endonuclease ACZ76_02445 ENOG4105CXG d-lactate dehydrogenase ACZ76_02450 ENOG41061WM D-Alanyl-D-Alanine ACZ76_02465 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ACZ76_02470 ENOG4105C1J atp-dependent rna helicase ACZ76_02475 ENOG4107MVR Transcriptional regulator ACZ76_02480 ENOG4105D0S secretion protein (HlyD ACZ76_02485 ENOG4105CJ1 ABC, transporter ACZ76_02490 ENOG4107QWP ABC-2 type transporter ACZ76_02495 ENOG4107QWP ABC-2 type transporter ACZ76_02500 ENOG4105HFZ Membrane ACZ76_02505 ENOG4108ZAF Molybdopterin ACZ76_02510 ENOG4105M00 molybdopterin converting factor, subunit 1 ACZ76_02515 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACZ76_02520 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACZ76_02525 ENOG4105CHW UPF0052 protein ACZ76_02530 ENOG4105VYA Uncharacterized conserved protein (DUF2132) ACZ76_02535 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ACZ76_02545 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ACZ76_02550 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ACZ76_02560 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ACZ76_02575 ENOG4108K4B hydrolase ACZ76_02580 ENOG4105PTV Nudix Hydrolase ACZ76_02585 ENOG4108RE9 Phosphodiesterase ACZ76_02595 ENOG4105ECP epimerase ACZ76_02600 ENOG4108JEH abc transporter atp-binding protein ACZ76_02605 ENOG4106YG3 ABC transporter ACZ76_02610 ENOG4105DSP amino acid AbC transporter ACZ76_02615 ENOG4105E89 ABC transporter ACZ76_02620 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ACZ76_02625 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ACZ76_02630 ENOG4105E96 Colicin v production protein ACZ76_02635 ENOG4108S3P Sporulation domain protein ACZ76_02640 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ACZ76_02650 ENOG4105DQR SNARE associated Golgi ACZ76_02660 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ACZ76_02680 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ACZ76_02690 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ACZ76_02700 ENOG4106WZ1 flagella biosynthesis regulator ACZ76_02705 ENOG4105F4P )-transporter ACZ76_02710 ENOG4105D6F Phosphatase ACZ76_02720 ENOG4105BZU Histidine kinase ACZ76_02725 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACZ76_02735 ENOG4105MH2 YfcL protein ACZ76_02740 ENOG4108BPE -transporting atpase ACZ76_02745 ENOG4105EJ9 Membrane ACZ76_02750 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) ACZ76_02755 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ACZ76_02760 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ACZ76_02765 ENOG4108DG9 Smr protein MutS2 ACZ76_02775 ENOG4108BY2 phosphohistidine phosphatase ACZ76_02780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ACZ76_02785 ENOG4105CHU acetyl-coa acetyltransferase ACZ76_02790 ENOG4105KZW UPF0381 protein ACZ76_02795 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ACZ76_02810 ENOG410903C (LipO)protein ACZ76_02815 ENOG4105KWW Biogenesis protein ACZ76_02820 ENOG4105KWW Biogenesis protein ACZ76_02825 ENOG4107QX9 Thiol disulfide interChange protein ACZ76_02830 ENOG4105DA4 cytochrome c-type biogenesis protein ACZ76_02835 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) ACZ76_02840 ENOG4105X3C heme exporter protein ACZ76_02845 ENOG41060IM Heme exporter protein ACZ76_02850 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ACZ76_02865 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ACZ76_02870 ENOG4105NTW Transcriptional regulator ACZ76_02880 ENOG4105CS2 ec 3.2.1.21 ACZ76_02885 ENOG4105C5Y PTS System ACZ76_02890 ENOG4105DDV Transcriptional regulator (LacI family ACZ76_02895 ENOG4108YYC ycei family ACZ76_02900 ENOG4105DS1 cytochrome b561 ACZ76_02915 ENOG4105DHJ ABC, transporter ACZ76_02940 ENOG4105CUB amino acid ACZ76_02945 ENOG4105CVE Lytic murein transglycosylase ACZ76_02960 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACZ76_02970 ENOG4107QY8 reductase ACZ76_02975 ENOG4105QAX Iron-sulfur ACZ76_02980 ENOG4107KGK dmso reductase anchor subunit ACZ76_02985 ENOG4108NEM leader-binding protein dmsD ACZ76_02990 ENOG4107Y60 (LipO)protein ACZ76_03000 ENOG4106B0W Curli production assembly transport component CsgG ACZ76_03005 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin ACZ76_03010 ENOG4108VKM cytochrome b561 ACZ76_03015 ENOG4105CHM Aminotransferase ACZ76_03025 ENOG41072TH Protein of unknown function (DUF1479) ACZ76_03030 ENOG4108HRK Histidine kinase ACZ76_03035 ENOG4105DY9 regulatoR ACZ76_03040 ENOG4105FCD Major Facilitator ACZ76_03045 ENOG4105CHC glucokinase (EC 2.7.1.2) ACZ76_03060 ENOG4107RA9 decarboxylase ACZ76_03065 ENOG4105CPC Aldo Keto reductase ACZ76_03075 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ACZ76_03080 ENOG4105D9N nucleoside ACZ76_03105 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ACZ76_03135 ENOG4105VRT cytoplasmic protein ACZ76_03140 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ACZ76_03150 ENOG4105EXN Sulfate transport protein CysZ ACZ76_03155 ENOG4105C6T cysteine synthase ACZ76_03160 ENOG4105KZ7 phosphocarrier protein hpr ACZ76_03165 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ACZ76_03170 ENOG4105C5Y PTS System ACZ76_03175 ENOG4105E0F Histidine kinase ACZ76_03180 ENOG4105E3W Two component transcriptional regulator (Winged helix family ACZ76_03185 ENOG4105DJY efflux transporter, rnd family, mfp subunit ACZ76_03195 ENOG4105C6T cysteine synthase ACZ76_03205 ENOG4105ECW sulfate abc transporter ACZ76_03210 ENOG4108I5D sulfate abc transporter ACZ76_03215 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ACZ76_03225 ENOG4105QEK Transcriptional regulator ACZ76_03230 ENOG4108R66 Conserved Protein ACZ76_03250 ENOG4105EZR dyp-type peroxidase family protein ACZ76_03255 ENOG4105E7K (LipO)protein ACZ76_03265 ENOG4105H4F exported protein ACZ76_03270 ENOG4105CHR reductase ACZ76_03275 ENOG4105KHC sulfurtransferase ACZ76_03295 ENOG4105CNN ABC, transporter ACZ76_03300 ENOG4105C2J ABC transporter ACZ76_03305 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ACZ76_03310 ENOG4108R6G acetyltransferase ACZ76_03315 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ACZ76_03320 ENOG4108UPT UPF0178 protein ACZ76_03325 ENOG4105C6K Malic enzyme ACZ76_03330 ENOG4107VIJ nudix hydrolase ACZ76_03335 ENOG4105CUW cytochrome C-TYPE protein ACZ76_03340 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) ACZ76_03345 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACZ76_03350 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase ACZ76_03355 ENOG4108ZNS ferredoxin-type protein NapF ACZ76_03360 ENOG4105WH1 Two component transcriptional regulator luxr family ACZ76_03370 ENOG4105BZS acriflavin resistance protein ACZ76_03380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACZ76_03385 ENOG4107Z33 ABC transporter, permease ACZ76_03400 ENOG4105KUZ arsenate reductase ACZ76_03405 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) ACZ76_03415 ENOG4105XYK UPF0370 protein ACZ76_03420 ENOG4106KED esterase YpfH ACZ76_03425 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ACZ76_03430 ENOG4108VMM UPF0756 membrane protein ACZ76_03435 ENOG4105CGZ zinc metallopeptidase ACZ76_03440 ENOG4105C8V SAICAR synthetase ACZ76_03445 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ACZ76_03450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACZ76_03455 ENOG4105RH4 Glycine cleavage system transcriptional repressor ACZ76_03460 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ACZ76_03465 ENOG4105C02 permease ACZ76_03470 ENOG4105ERG peptidase m48, ste24p ACZ76_03475 ENOG4105K89 arsenate reductase ACZ76_03480 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) ACZ76_03485 ENOG4105C2W permease ACZ76_03495 ENOG4105CXB phosphoribosylaminoimidazole synthetase ACZ76_03500 ENOG4108V3E phosphoribosylglycinamide formyltransferase ACZ76_03505 ENOG4108MK9 spermidine N(1)-acetyltransferase ACZ76_03510 ENOG4108C80 FliB family ACZ76_03525 ENOG4105E2Z phosphate ABC transporter (Permease ACZ76_03530 ENOG4105C8U phosphate abc transporter ACZ76_03535 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ACZ76_03540 ENOG4105C9X ppx gppa phosphatase ACZ76_03550 ENOG4105CJW magnesium transporter ACZ76_03555 ENOG4105BZU Histidine kinase ACZ76_03560 ENOG4105R8A Heat shock protein ACZ76_03570 ENOG4105ENT Efflux transporter rnd family, mfp subunit ACZ76_03580 ENOG4105BZS acriflavin resistance protein ACZ76_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACZ76_03595 ENOG4105EB3 Histidine kinase ACZ76_03600 ENOG4105E3W Two component transcriptional regulator (Winged helix family ACZ76_03605 ENOG4105KWI UPF0339 protein ACZ76_03610 ENOG4105CFP Peptidase U32 ACZ76_03615 ENOG4107TE5 Lipid kinase ACZ76_03620 ENOG410787A Pts system, glucitol sorbitol-specific ACZ76_03625 ENOG4105DZY Pts system, glucitol sorbitol-specific ACZ76_03630 ENOG4105VI0 Pts system, glucitol sorbitol-specific ACZ76_03635 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase ACZ76_03640 ENOG4105J92 DNA-binding transcriptional activator GutM ACZ76_03645 ENOG410804X Transcriptional regulator ACZ76_03655 ENOG4108ZGU inhibitor of vertebrate lysozyme ACZ76_03665 ENOG4105DWF phosphomethylpyrimidine kinase ACZ76_03690 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ACZ76_03695 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ACZ76_03700 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ACZ76_03705 ENOG4105VPD cellular component movement ACZ76_03715 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ACZ76_03720 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ACZ76_03725 ENOG4105N21 Membrane ACZ76_03765 ENOG4108JQB penicillin-binding protein 1C ACZ76_03770 ENOG4105DN3 alpha-2-macroglobulin domain protein ACZ76_03775 ENOG4108MGN ATP-binding component of a transport system ACZ76_03780 ENOG4108MGN ATP-binding component of a transport system ACZ76_03785 ENOG4105YYA enhanced serine sensitivity protein SseB ACZ76_03795 ENOG4105WVQ Fe-S assembly protein IscX ACZ76_03800 ENOG4108ZIT Ferredoxin, 2FE-2S ACZ76_03805 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB ACZ76_03820 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ACZ76_03825 ENOG4105C3J Cysteine desulfurase ACZ76_03830 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ACZ76_03835 ENOG4105CVS RNA methyltransferase TrmH family, group 1 ACZ76_03845 ENOG4105D7X high-affinity nickel-transporter ACZ76_03850 ENOG41065CD Exported protein ACZ76_03855 ENOG4108MN2 Stationary phase inducible protein CsiE ACZ76_03860 ENOG4105D8G Major Facilitator superfamily ACZ76_03870 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ACZ76_03875 ENOG4108M21 ACZ76_03880 ENOG4105RMW regulation of transcription, DNA-dependent ACZ76_03885 ENOG4108626 Racemase ACZ76_03890 ENOG4108YZA Nitrogen regulatory protein pii ACZ76_03895 ENOG4105C4K Nad synthetase ACZ76_03900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACZ76_03905 ENOG4108SKK alpha helix protein ACZ76_03910 ENOG4107WP9 Histidine kinase ACZ76_03925 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) ACZ76_03930 ENOG4108Z6B deaminase ACZ76_03940 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB ACZ76_03955 ENOG4106G6Q Transcriptional regulator ACZ76_03960 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ACZ76_03965 ENOG4107EFN gluconate transport system permease 3 ACZ76_03970 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ACZ76_03975 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ACZ76_03980 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ACZ76_03985 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ACZ76_03995 ENOG4105C3F Signal peptidase i ACZ76_04000 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ACZ76_04010 ENOG4105WMJ Positive regulator of sigma E, RseC MucC ACZ76_04020 ENOG41069PW sigma-e factor negative regulatory protein ACZ76_04030 ENOG4108IYU L-aspartate oxidase ACZ76_04035 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) ACZ76_04040 ENOG4105C1J atp-dependent rna helicase ACZ76_04045 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) ACZ76_04050 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ACZ76_04055 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ACZ76_04060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ACZ76_04065 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ACZ76_04070 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ACZ76_04080 ENOG4108Z1B Cyclase dehydrase ACZ76_04085 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ACZ76_04090 ENOG4105DFP Integrase ACZ76_04215 ENOG4105EZV Transcriptional regulator ACZ76_04220 ENOG4105VCP PTS System ACZ76_04225 ENOG4105CS2 ec 3.2.1.21 ACZ76_04230 ENOG4105CK1 PTS System ACZ76_04235 ENOG4105VZJ PTS System ACZ76_04240 ENOG4105D8V Glucose sorbosone dehydrogenase ACZ76_04250 ENOG41086WQ Protein CrcB homolog ACZ76_04255 ENOG4107SVH Potassium channel protein ACZ76_04260 ENOG4105XXV Acid-resistance protein ACZ76_04295 ENOG4105CQM Urea amidohydrolase subunit alpha ACZ76_04300 ENOG4105KI2 Urea amidohydrolase subunit beta ACZ76_04310 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) ACZ76_04320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACZ76_04325 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACZ76_04340 ENOG4105VEQ Cold shock protein ACZ76_04350 ENOG4108SAJ Protein of unknown function (DUF1198) ACZ76_04355 ENOG4108WMJ Protein of unknown function (DUF2002) ACZ76_04365 ENOG4105NE1 Conserved Protein ACZ76_04375 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ACZ76_04380 ENOG4105WAZ (Glutaredoxin-like protein) NrdH ACZ76_04385 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ACZ76_04395 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACZ76_04400 ENOG4108IJ7 Glycine betaine ACZ76_04405 ENOG4108HQS Glycine betaine ACZ76_04410 ENOG4105GIJ Glycine betaine ACZ76_04420 ENOG4108JDX DNA polymerase iii, epsilon subunit ACZ76_04425 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ACZ76_04430 ENOG4105D1A Methyltransferase ACZ76_04435 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ACZ76_04440 ENOG4105E9H Lytic Murein transglycosylase ACZ76_04445 ENOG4107NA1 Endonuclease Exonuclease phosphatase ACZ76_04450 ENOG4105CV8 reductase ACZ76_04485 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ACZ76_04495 ENOG4108UMI ABC transporter, permease ACZ76_04500 ENOG4105D01 (LipO)protein ACZ76_04505 ENOG4108R8X outer membrane lipoprotein ACZ76_04510 ENOG4108R96 Methyltransferase, YaeB family ACZ76_04520 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion ACZ76_04525 ENOG4108YZN class I peptide chain release factor ACZ76_04530 ENOG4108VWS Yaeq family ACZ76_04540 ENOG4105M1T rho-binding antiterminator ACZ76_04555 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ACZ76_04570 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) ACZ76_04575 ENOG4105C0B DNA polymerase III (alpha subunit) ACZ76_04580 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ACZ76_04585 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACZ76_04590 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACZ76_04605 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) ACZ76_04615 ENOG4105DZP Membrane-associated zinc metalloprotease ACZ76_04620 ENOG4105KNE Phosphatidate cytidylyltransferase ACZ76_04625 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ACZ76_04630 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ACZ76_04635 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ACZ76_04640 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) ACZ76_04645 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ACZ76_04650 ENOG4105CE9 30S ribosomal protein S2 ACZ76_04655 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ACZ76_04660 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) ACZ76_04665 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ACZ76_04670 ENOG4108T8E UPF0325 protein ACZ76_04680 ENOG4105QDK Flavodoxin ACZ76_04685 ENOG4105DR9 pseudouridine synthase ACZ76_04690 ENOG4105WP7 tRNA pseudouridine synthase C ACZ76_04695 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) ACZ76_04700 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ACZ76_04705 ENOG4105EWT decarboxylase family ACZ76_04715 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) ACZ76_04720 ENOG4105M08 Membrane ACZ76_04725 ENOG4105ETT transcriptional Regulator, LysR family ACZ76_04730 ENOG4105M5B (LipO)protein ACZ76_04735 ENOG4105C9B Cysteine desulfurase ACZ76_04740 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ACZ76_04745 ENOG4105CUZ uba thif-type nad fad binding protein ACZ76_04750 ENOG4105CA3 membrane-bound lytic murein transglycosylase ACZ76_04770 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ACZ76_04775 ENOG4107QZM n-acetylglutamate synthase ACZ76_04780 ENOG4107QYX exodeoxyribonuclease v alpha ACZ76_04785 ENOG4107QKA exodeoxyribonuclease V beta ACZ76_04790 ENOG4107QXK peptidase ACZ76_04795 ENOG4105DSY exodeoxyribonuclease V, gamma ACZ76_04805 ENOG4105JCS prepilin peptidase dependent protein ACZ76_04825 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ACZ76_04830 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ACZ76_04835 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ACZ76_04840 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) ACZ76_04845 ENOG4105EE5 Membrane protein terC ACZ76_04850 ENOG4105CPC Aldo Keto reductase ACZ76_04860 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) ACZ76_04865 ENOG4105CEY Amp-dependent synthetase and ligase ACZ76_04875 ENOG41060NJ transcriptional regulator ACZ76_04880 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ACZ76_04885 ENOG4105RQF LysR family Transcriptional regulator ACZ76_04890 ENOG4105F27 Major Facilitator ACZ76_04895 ENOG4105EJC lysr family transcriptional regulator ACZ76_04920 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ACZ76_04955 ENOG4105D7Q type ii secretion system ACZ76_04960 ENOG4107QHF type ii secretion system protein e ACZ76_04980 ENOG4105KVH Transcriptional regulator ACZ76_04985 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr ACZ76_04995 ENOG4105DVC DnaJ domain protein ACZ76_05005 ENOG4105DPW Major facilitator superfamily MFS_1 ACZ76_05020 ENOG4105F7P transcriptional regulator AsnC family ACZ76_05025 ENOG4105BZU Histidine kinase ACZ76_05030 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein ACZ76_05050 ENOG4105CRK lysyL-tRNA synthetase ACZ76_05055 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ACZ76_05060 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ACZ76_05065 ENOG4105T95 Thiol disulfide interChange protein ACZ76_05070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACZ76_05075 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ACZ76_05080 ENOG4105CT7 inner membrane cred family protein ACZ76_05085 ENOG4105EB3 Histidine kinase ACZ76_05090 ENOG4105E3W Two component transcriptional regulator (Winged helix family ACZ76_05100 ENOG4105Y75 tpr repeat protein ACZ76_05105 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ACZ76_05110 ENOG4108UT2 hemolysin iii ACZ76_05115 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ACZ76_05120 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ACZ76_05125 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ACZ76_05130 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ACZ76_05135 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ACZ76_05140 ENOG4105D0A hydroxylase ACZ76_05145 ENOG4107RAQ aminopeptidase ACZ76_05150 ENOG4105E07 UPF0149 protein ACZ76_05155 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) ACZ76_05160 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ACZ76_05165 ENOG4108JQ1 Dehydrogenase ACZ76_05170 ENOG4105E66 phosphoriboisomerase A ACZ76_05175 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ACZ76_05180 ENOG4105MPN Membrane ACZ76_05185 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ACZ76_05190 ENOG4105D64 Mechanosensitive ion channel ACZ76_05200 ENOG4105D2N Aldolase ACZ76_05205 ENOG4105BZA Phosphoglycerate kinase ACZ76_05210 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ACZ76_05220 ENOG4105CV1 Transketolase (EC 2.2.1.1) ACZ76_05225 ENOG4108K0D peptidase, M48 ACZ76_05235 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ACZ76_05245 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ACZ76_05260 ENOG41080HT Transcriptional regulator, arsr family ACZ76_05265 ENOG4105GPY SprT protein ACZ76_05270 ENOG4105RWS endonuclease I ACZ76_05275 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ACZ76_05280 ENOG4105D7Z glutathione synthase ACZ76_05285 ENOG4108UJU UPF0301 protein ACZ76_05290 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ACZ76_05295 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) ACZ76_05305 ENOG4105CZX twitching motility protein ACZ76_05310 ENOG4105DFA alanine racemase domain protein ACZ76_05315 ENOG4105II7 pyrroline-5-carboxylate reductase ACZ76_05320 ENOG4108VIA integral membrane protein ACZ76_05325 ENOG4105VZ9 UPF0235 protein ACZ76_05330 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ACZ76_05335 ENOG4105CSA Coproporphyrinogen iii oxidase ACZ76_05340 ENOG4105F9F transposase ACZ76_05350 ENOG4105K33 Periplasmic Protein ACZ76_05355 ENOG4105CSV Glutaminase ACZ76_05360 ENOG41090ED Protein with unknown function (DUF469) ACZ76_05365 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ACZ76_05370 ENOG4105CEN a g-specific adenine glycosylase ACZ76_05380 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division ACZ76_05385 ENOG4105CXN decarboxylase ACZ76_05510 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACZ76_05545 ENOG4107B2H carbonic anhydrase ACZ76_05555 ENOG4108MI0 Resistance protein ACZ76_05560 ENOG4105J12 Multidrug resistance protein mdtN ACZ76_05590 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase ACZ76_05595 ENOG4108Q3X Transcriptional regulator ACZ76_05600 ENOG4105CEE C4-dicarboxylate transporter ACZ76_05605 ENOG4107R1I NAD-dependent malic enzyme ACZ76_05615 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ACZ76_05620 ENOG4108IPW abc transporter atp-binding protein ACZ76_05625 ENOG4105CM4 permease protein ACZ76_05645 ENOG4105ETE Transcriptional regulator (LacI family ACZ76_05655 ENOG4105EAM Na Pi-cotransporter ACZ76_05670 ENOG4105CSH Transporter ACZ76_05675 ENOG4107FQ9 ethanolamine ammonia-lyase ACZ76_05680 ENOG4105CPD ethanolamine ammonia-lyase ACZ76_05685 ENOG4105C85 amino acid ACZ76_05695 ENOG4108KX4 response regulator ACZ76_05710 ENOG4105C1P efflux transporter, rnd family, mfp subunit ACZ76_05720 ENOG4105C8H hydrogenase maturation protein Hypf ACZ76_05725 ENOG4105C45 hydrogenase expression formation protein (HypE) ACZ76_05730 ENOG4105CQS hydrogenase expression formation protein HypD ACZ76_05735 ENOG41082MF Hydrogenase assembly chaperone hypC hupF ACZ76_05740 ENOG4107RSS Hydrogenase accessory protein HypB ACZ76_05745 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ACZ76_05750 ENOG4108WGS hydrogenase 2-specific chaperone ACZ76_05755 ENOG4108USZ hydrogenase ACZ76_05760 ENOG4105DPX Hydrogenase, large subunit ACZ76_05765 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit ACZ76_05770 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACZ76_05775 ENOG4105E3S small subunit ACZ76_05790 ENOG4108XTF Outer Membrane Lipoprotein ACZ76_05800 ENOG4107RD7 Flagellar Motor Protein, MotA ACZ76_05825 ENOG4105MQ3 flagellar protein FliS ACZ76_05830 ENOG410804A Flagellar hook-associated 2 domain-containing protein ACZ76_05835 ENOG4105I03 Flagellin ACZ76_05840 ENOG4108M3R transcriptional activator CadC ACZ76_05870 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) ACZ76_05880 ENOG4105CGA flagellar basal-body rod protein FlgG ACZ76_05885 ENOG4108KPB Flagellar basal-body rod protein FlgF ACZ76_05890 ENOG4105BZE flagellar hook protein, FlgE ACZ76_05895 ENOG4105W00 Flagellar hook capping protein ACZ76_05900 ENOG4108ZC9 flagellar basal-body rod protein flgc ACZ76_05905 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ACZ76_05930 ENOG4108JIR Flagellum-specific ATP synthase ACZ76_05945 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ACZ76_05950 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ACZ76_05955 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACZ76_05965 ENOG4105DD5 Flagellar motor switch protein ACZ76_05970 ENOG4105CN7 Flagellar biosynthetic protein FliP ACZ76_05975 ENOG4105VS8 Flagellar biosynthetic protein fliq ACZ76_05980 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ACZ76_05985 ENOG4105D00 flagellar biosynthetic protein flhB ACZ76_06000 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_06005 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein ACZ76_06015 ENOG4105DQ5 transport system permease protein ACZ76_06020 ENOG4105TVJ transport system, permease ACZ76_06025 ENOG4105E0A ABC, transporter ACZ76_06050 ENOG4105EP1 Efflux transporter rnd family, mfp subunit ACZ76_06055 ENOG4108IJF Heavy metal efflux pump, CzcA ACZ76_06130 ENOG4108ZZF transport protein (ExbD) ACZ76_06135 ENOG4105CWK Biopolymer transport protein, ExbB ACZ76_06140 ENOG4105C28 cystathionine ACZ76_06145 ENOG4108K81 inner membrane protein YghB ACZ76_06150 ENOG4105CF7 AraC family transcriptional regulator ACZ76_06155 ENOG4108I6A alcohol dehydrogenase ACZ76_06160 ENOG4105CV8 reductase ACZ76_06170 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) ACZ76_06175 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ACZ76_06180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACZ76_06185 ENOG4105NF4 modulator of drug activity ACZ76_06190 ENOG4105VRH Antibiotic biosynthesis monooxygenase ACZ76_06195 ENOG4105JQN Transcriptional regulator ACZ76_06200 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACZ76_06205 ENOG4105IPS esterase ACZ76_06210 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ACZ76_06215 ENOG4108SX3 cytoplasmic protein ACZ76_06220 ENOG41087AY ADP-Ribose pyrophosphatase ACZ76_06225 ENOG4105DFG type I secretion outer membrane protein ACZ76_06230 ENOG4105F1G UPF0441 protein ACZ76_06235 ENOG4106032 Glutathionylspermidine synthase ACZ76_06240 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ACZ76_06245 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ACZ76_06250 ENOG4105W0Z cytoplasmic protein ACZ76_06255 ENOG4105DVH amino acid ACZ76_06260 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) ACZ76_06265 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ACZ76_06270 ENOG4105I7R Adenylate cyclase ACZ76_06275 ENOG4106MWK domain protein ACZ76_06280 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ACZ76_06285 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ACZ76_06290 ENOG4107ZVW dihydroneopterin aldolase ACZ76_06295 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ACZ76_06300 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ACZ76_06305 ENOG4105VCC 30S ribosomal protein S21 ACZ76_06310 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ACZ76_06315 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACZ76_06325 ENOG4105C2C drug resistance transporter, Bcr CflA ACZ76_06330 ENOG4108YK4 Acid-resistance membrane protein ACZ76_06335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACZ76_06345 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ACZ76_06355 ENOG4108VKG metal-dependent hydrolase ACZ76_06360 ENOG4105EE0 oxidoreductase ACZ76_06365 ENOG4105DU1 integral membrane protein, terc ACZ76_06370 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ACZ76_06375 ENOG4105P66 Membrane ACZ76_06380 ENOG4105CTX dehydratase ACZ76_06385 ENOG4107QZW Altronate oxidoreductase ACZ76_06390 ENOG4105D2H Uronic isomerase ACZ76_06395 ENOG4105DPW Major facilitator superfamily MFS_1 ACZ76_06415 ENOG4106W5V Membrane ACZ76_06430 ENOG4105NE1 Conserved Protein ACZ76_06435 ENOG41090KG Inner membrane protein YqjE ACZ76_06440 ENOG4105YJD ACZ76_06445 ENOG4108VBZ doxx family ACZ76_06450 ENOG4105CHF Glutathione S-transferase ACZ76_06455 ENOG4105CWB LysR family transcriptional Regulator ACZ76_06460 ENOG4108CNN domain protein ACZ76_06465 ENOG4106KR7 LysR family Transcriptional regulator ACZ76_06475 ENOG4106KR7 LysR family Transcriptional regulator ACZ76_06480 ENOG4105DQ4 alcohol dehydrogenase ACZ76_06490 ENOG4105EQ2 LysR family Transcriptional regulator ACZ76_06510 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ACZ76_06520 ENOG41082RQ UPF0102 protein ACZ76_06525 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ACZ76_06530 ENOG4105W4M Transport-associated protein ACZ76_06535 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase ACZ76_06540 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ACZ76_06545 ENOG4105BZU Histidine kinase ACZ76_06550 ENOG4105N5T Radical SAM Protein ACZ76_06555 ENOG4105CBC glutamate synthase ACZ76_06560 ENOG4105BZ8 glutamate synthase ACZ76_06570 ENOG4105KB2 stringent starvation protein b ACZ76_06575 ENOG4107MKT Stringent starvation protein a ACZ76_06580 ENOG4108UJD 30S ribosomal protein S9 ACZ76_06585 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ACZ76_06590 ENOG4105D6Z AFG1 family ATPase ACZ76_06595 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III ACZ76_06600 ENOG4105C0H protease ACZ76_06605 ENOG4105C0H protease ACZ76_06615 ENOG4105VFK BolA family ACZ76_06620 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane ACZ76_06625 ENOG4105E3I toluene tolerance ACZ76_06630 ENOG4107PE3 Mammalian cell entry related domain protein ACZ76_06635 ENOG4105CY3 ABC transporter, permease ACZ76_06640 ENOG4105DHJ ABC, transporter ACZ76_06645 ENOG4105FEU K -dependent Na -Ca exchanger ACZ76_06650 ENOG4105C2X Arabinose 5-phosphate isomerase ACZ76_06655 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ACZ76_06660 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) ACZ76_06665 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ACZ76_06670 ENOG4108IUZ ABC transporter ACZ76_06675 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACZ76_06680 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ACZ76_06685 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ACZ76_06695 ENOG41080Z8 PHOSPHOCARRIER protein ACZ76_06700 ENOG4105CXT aspartate transcarbamylase ACZ76_06705 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) ACZ76_06710 ENOG4105KME endoribonuclease L-psp ACZ76_06735 ENOG4105CG3 alpha amylase, catalytic region ACZ76_06740 ENOG4105C5Y PTS System ACZ76_06745 ENOG4105D4X repressor ACZ76_06750 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ACZ76_06755 ENOG4105EMD TRANSCRIPTIONal ACZ76_06760 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) ACZ76_06775 ENOG41069H0 dihydroorotase EC 3.5.2.3 ACZ76_06805 ENOG4105NXH GreA GreB family elongation factor ACZ76_06810 ENOG4108XVM Cytochrome b(562) ACZ76_06815 ENOG4105CMS peptidase U62, modulator of DNA gyrase ACZ76_06820 ENOG4105N42 UPF0307 protein ACZ76_06825 ENOG4105UNR (Barnase) inhibitor ACZ76_06835 ENOG4105C26 Dehydrogenase ACZ76_06840 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) ACZ76_06845 ENOG4105Y49 secretion protein, HlyD family ACZ76_06850 ENOG4105ZQC membrane protein AaeX ACZ76_06855 ENOG4105CR8 Transcriptional regulator ACZ76_06860 ENOG4105D1U peptidase U62 modulator of DNA gyrase ACZ76_06870 ENOG4105QD6 exported protein ACZ76_06875 ENOG4105C03 ribonuclease ACZ76_06885 ENOG4105VQ7 Rod shape-determining protein MreD ACZ76_06890 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ACZ76_06895 ENOG4105DFF Rod shape-determining protein mreb ACZ76_06900 ENOG41062P1 Diguanylate cyclase phosphodiesterase ACZ76_06905 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ACZ76_06915 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) ACZ76_06920 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ACZ76_06925 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ACZ76_06930 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACZ76_06935 ENOG4105RG0 Membrane ACZ76_06940 ENOG4108IA2 Sodium pantothenate symporter ACZ76_06945 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ACZ76_06950 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ACZ76_06955 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ACZ76_06965 ENOG4105CAR Terminase, large subunit ACZ76_07055 ENOG4105BZU Histidine kinase ACZ76_07060 ENOG4108XTF Outer Membrane Lipoprotein ACZ76_07065 ENOG4105VEQ Cold shock protein ACZ76_07070 ENOG4105VEQ Cold shock protein ACZ76_07075 ENOG4107QPK )-transporter ACZ76_07080 ENOG4105C2X Arabinose 5-phosphate isomerase ACZ76_07085 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACZ76_07095 ENOG4105CNN ABC, transporter ACZ76_07100 ENOG4105C2J ABC transporter ACZ76_07110 ENOG4105D1S lipid A biosynthesis ACZ76_07120 ENOG4105EZ7 amino acid ABC transporter ACZ76_07125 ENOG4105DRP amino acid AbC transporter ACZ76_07130 ENOG4105CDA abc transporter atp-binding protein ACZ76_07150 ENOG4105CMU LysR family (Transcriptional regulator ACZ76_07155 ENOG4105EEQ Na H antiporter ACZ76_07165 ENOG4105C7N Xanthine uracil vitamin C permease ACZ76_07175 ENOG4108UUM single-stranded DNA-binding protein ACZ76_07180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ACZ76_07185 ENOG4105MSB protein, conserved in bacteria ACZ76_07190 ENOG4105CGF Aromatic amino acid aminotransferase ACZ76_07195 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ACZ76_07200 ENOG4105CDU Replicative dna helicase ACZ76_07205 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ACZ76_07215 ENOG4105P4Z Phage shock protein G ACZ76_07220 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ACZ76_07225 ENOG4105MYN Zinc uptake regulation protein ACZ76_07230 ENOG4105VDW Csbd family ACZ76_07235 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACZ76_07240 ENOG41080IJ Diacylglycerol kinase ACZ76_07245 ENOG4105E55 glycerol-3-phosphate acyltransferase ACZ76_07250 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ACZ76_07255 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) ACZ76_07265 ENOG4107W52 maltose operon periplasmic protein ACZ76_07270 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) ACZ76_07280 ENOG4107FKK extracellular solute-binding protein family 1 ACZ76_07285 ENOG4105D56 permease protein ACZ76_07290 ENOG4105EG2 ABC transporter, permease ACZ76_07295 ENOG4108VY7 phosphate-starvation-inducible protein PsiE ACZ76_07305 ENOG4105CFH Aspartokinase ACZ76_07320 ENOG4105C3R Methionine synthase ACZ76_07325 ENOG41069M3 Transcriptional regulator ACZ76_07330 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) ACZ76_07335 ENOG4108I9X Isocitrate lyase ACZ76_07340 ENOG4107QP3 malate synthase g ACZ76_07345 ENOG4105CVG Homoserine O-transsuccinylase ACZ76_07390 ENOG4105C12 Phosphoribosylglycinamide synthetase ACZ76_07395 ENOG4108T8B Protein of unknown function (DUF1481) ACZ76_07405 ENOG4105R2J Conserved Protein ACZ76_07410 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) ACZ76_07420 ENOG4105E09 nadh pyrophosphatase ACZ76_07425 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor ACZ76_07430 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ACZ76_07440 ENOG4105D06 uba thif-type nad fad binding protein ACZ76_07445 ENOG4105WHD thiamine biosynthesis protein ThiS ACZ76_07450 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ACZ76_07455 ENOG4105D41 biosynthesis protein thiH ACZ76_07470 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ACZ76_07475 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ACZ76_07480 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ACZ76_07485 ENOG4108VZM 50s ribosomal protein L10 ACZ76_07490 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ACZ76_07495 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ACZ76_07500 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ACZ76_07505 ENOG4105PM1 preprotein translocase subunit SecE ACZ76_07540 ENOG4105CS9 pantothenic acid kinase ACZ76_07545 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ACZ76_07575 ENOG4108Z0R Transferase ACZ76_07580 ENOG4105E2X shikimate dehydrogenase ACZ76_07585 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ACZ76_07590 ENOG4108WI1 Dna topoisomerase ACZ76_07600 ENOG4105C79 DNA protecting protein DprA ACZ76_07605 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ACZ76_07610 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ACZ76_07615 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ACZ76_07620 ENOG4105C1A potassium transporter peripheral membrane ACZ76_07625 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ACZ76_07630 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system ACZ76_07635 ENOG4105W1Y Transcriptional regulator ACZ76_07640 ENOG4105VTS DnaJ-like, subfamily C ACZ76_07645 ENOG4108ZT0 50S ribosomal protein l17 ACZ76_07650 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ACZ76_07655 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ACZ76_07660 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ACZ76_07665 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ACZ76_07670 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ACZ76_07675 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ACZ76_07680 ENOG4105VPB 50S ribosomal protein L30 ACZ76_07685 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ACZ76_07690 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ACZ76_07695 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ACZ76_07705 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ACZ76_07725 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ACZ76_07730 ENOG41083MP 50s ribosomal protein l29 ACZ76_07735 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ACZ76_07740 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ACZ76_07745 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ACZ76_07750 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ACZ76_07755 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ACZ76_07760 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ACZ76_07770 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ACZ76_07785 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ACZ76_07795 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ACZ76_07805 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ACZ76_07810 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) ACZ76_07815 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) ACZ76_07820 ENOG4105WWK YheO domain protein ACZ76_07825 ENOG4108V1T peptidylprolyl cis-trans isomerase ACZ76_07835 ENOG4108YZY peptidylprolyl cis-trans isomerase ACZ76_07840 ENOG4105VKU nucleicacid-binding protein ACZ76_07850 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ACZ76_07855 ENOG4105C5H ABC transporter ACZ76_07860 ENOG4105K64 Glycosyl transferase, family 2 ACZ76_07865 ENOG4105E2B Taurine dioxygenase ACZ76_07870 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ACZ76_07880 ENOG4106FTQ Taurine ABC transporter, periplasmic ACZ76_07885 ENOG4105JAB phenazine biosynthesis protein, phzf family ACZ76_07895 ENOG4105DNZ Alpha Beta Hydrolase ACZ76_07900 ENOG4105YP7 UPF0270 protein ACZ76_07905 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ACZ76_07910 ENOG4108UKZ OsmC family ACZ76_07920 ENOG410613R integral membrane protein, YccS YhfK family ACZ76_07925 ENOG4105C8Y Acetylornithine aminotransferase ACZ76_07945 ENOG4105D7A ATP-binding protein ACZ76_07950 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ACZ76_07955 ENOG4105F8D glycoside hydrolase family 4 ACZ76_07960 ENOG41060NJ transcriptional regulator ACZ76_07975 ENOG4106DTQ Protein TsgA homolog ACZ76_07980 ENOG4105DZC cytosine deaminase ACZ76_07985 ENOG4107QZF nitrite reductase NADPH large subunit ACZ76_07990 ENOG4105WZK nitrite reductase NADPH small subunit ACZ76_07995 ENOG4107V9H nitrite transporter ACZ76_08000 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ACZ76_08005 ENOG4105C31 Tryptophanyl-tRNA synthetase ACZ76_08015 ENOG4105DJV ribulose-phosphate 3-epimerase ACZ76_08035 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ACZ76_08040 ENOG4105E4G Type IV pilus ACZ76_08065 ENOG4108JQC penicillin-binding protein 1A ACZ76_08070 ENOG4107RK2 ADP-ribose diphosphatase NudE ACZ76_08075 ENOG4105DQY intracellular growth attenuator ACZ76_08080 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 ACZ76_08085 ENOG4105VEJ Heat shock protein ACZ76_08095 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ACZ76_08100 ENOG4105E0F Histidine kinase ACZ76_08105 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACZ76_08110 ENOG4108RRZ Transcription elongation factor GreB ACZ76_08135 ENOG4105BZM domain protein ACZ76_08140 ENOG4105XFK Ferrous iron transport protein A ACZ76_08145 ENOG4105CE1 Ferrous iron transport protein b ACZ76_08150 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) ACZ76_08155 ENOG4105RID UPF0379 protein yhcN ACZ76_08160 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ACZ76_08165 ENOG4105MJ2 Competence protein ACZ76_08170 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) ACZ76_08175 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ACZ76_08180 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ACZ76_08185 ENOG41061ZR Transcriptional regulator ACZ76_08200 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) ACZ76_08205 ENOG4105E98 transcriptional regulator DeoR family ACZ76_08210 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ACZ76_08215 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ACZ76_08220 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ACZ76_08230 ENOG4108IUM Glycogen debranching enzyme ACZ76_08235 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) ACZ76_08240 ENOG4108HRK Histidine kinase ACZ76_08245 ENOG4108JJA ABC, transporter ACZ76_08250 ENOG4108MBX Secretion Protein ACZ76_08260 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ACZ76_08265 ENOG41076UM multiple antibiotic resistance (MarC)-related protein ACZ76_08270 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ACZ76_08275 ENOG4105C6Z Gluconate ACZ76_08280 ENOG4105DIQ Transcriptional regulator ACZ76_08285 ENOG4105C2I pirin domain protein ACZ76_08290 ENOG4105WCN acetyltransferase ACZ76_08295 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) ACZ76_08300 ENOG4105F0H myo-inositol catabolism protein ACZ76_08305 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ACZ76_08315 ENOG4105EDK PfkB domain protein ACZ76_08325 ENOG4105DH8 myo-inositol catabolism ACZ76_08330 ENOG4105C26 Dehydrogenase ACZ76_08345 ENOG4105EQ0 Major Facilitator superfamily ACZ76_08350 ENOG4105CR8 Transcriptional regulator ACZ76_08370 ENOG4105CW0 outer membrane usher protein ACZ76_08375 ENOG4108AF8 Chaperone ACZ76_08400 ENOG4105CBX hi0933 family ACZ76_08405 ENOG4105CJ3 phosphate transporter ACZ76_08410 ENOG4108V6B universal stress protein B ACZ76_08415 ENOG4108M6U Universal stress protein A ACZ76_08430 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ACZ76_08435 ENOG4105DGW oligopeptidase A ACZ76_08440 ENOG4105D6S protein involved in catabolism of external DNA ACZ76_08445 ENOG4105DC8 reductase ACZ76_08455 ENOG4107H3J ribonuclease ACZ76_08460 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) ACZ76_08465 ENOG41066T0 asmA family ACZ76_08470 ENOG4105CMB EAL domain-containing protein ACZ76_08475 ENOG4105VSH 4-oxalocrotonate tautomerase ACZ76_08480 ENOG4107SS6 2-dehydro-3-deoxygluconokinase ACZ76_08485 ENOG4105CS0 peptidase ACZ76_08490 ENOG4105CK2 sodium dicarboxylate symporter ACZ76_08500 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ACZ76_08505 ENOG4105DSJ YicC domain protein ACZ76_08515 ENOG4105C7B Threonine dehydratase ACZ76_08520 ENOG4108SGR YheO domain-containing protein ACZ76_08530 ENOG41090BB DNA mismatch endonuclease (vsr) ACZ76_08540 ENOG4105D99 atp gtp-binding protein ACZ76_08545 ENOG4105R2A (LipO)protein ACZ76_08560 ENOG4105D0C transport protein ACZ76_08565 ENOG4105JKW Valine--pyruvate aminotransferase ACZ76_08570 ENOG4107T9C Alpha amylase catalytic region ACZ76_08590 ENOG4108ZG0 Ompa motb domain protein ACZ76_08600 ENOG4105HNP -acetyltransferase ACZ76_08605 ENOG4108R3E Dna-3-methyladenine glycosylase i ACZ76_08620 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ACZ76_08625 ENOG4106JH6 (LipO)protein ACZ76_08630 ENOG4105CTS PTS system mannitol-specific ACZ76_08635 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase ACZ76_08640 ENOG4105E61 Mannitol repressor protein ACZ76_08650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACZ76_08655 ENOG4108YYI Protein of unknown function (DUF2810) ACZ76_08665 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A ACZ76_08670 ENOG4108RPX mosc domain containing protein ACZ76_08675 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_08680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ACZ76_08685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ACZ76_08690 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACZ76_08695 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ACZ76_08700 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACZ76_08705 ENOG4108MG3 formate dehydrogenase ACZ76_08710 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) ACZ76_08715 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) ACZ76_08720 ENOG4105EM7 Selenocysteine-specific translation elongation factor ACZ76_08725 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ACZ76_08730 ENOG4105FB2 class II Aldolase ACZ76_08735 ENOG4105G63 Type III effector Hrp-dependent ACZ76_08740 ENOG4105MVE transcriptional regulator ACZ76_08745 ENOG4105CSP Major Facilitator Superfamily ACZ76_08750 ENOG4105EXW epimerase dehydratase ACZ76_08760 ENOG4105MEV Acyl-transferase ACZ76_08770 ENOG4108RWI nicotinamidase ACZ76_08785 ENOG4108TTM chaperone ACZ76_08795 ENOG4105CMG Carbohydrate kinase ACZ76_08800 ENOG4105C93 Xylose Isomerase ACZ76_08805 ENOG4105DFW ABC transporter ACZ76_08815 ENOG4107RNG ABC transporter ACZ76_08820 ENOG4105T16 Transcriptional regulator (AraC family) ACZ76_08830 ENOG41066YJ Beta-lactamase ACZ76_08835 ENOG410667J hydrolase ACZ76_08840 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACZ76_08850 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ACZ76_08855 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ACZ76_08860 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ACZ76_08865 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ACZ76_08870 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ACZ76_08875 ENOG4105RKW reductase (By ACZ76_08885 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ACZ76_08890 ENOG4108UMI ABC transporter, permease ACZ76_08895 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_08900 ENOG4108YYH Nadph-dependent fmn reductase ACZ76_08905 ENOG4105BZU Histidine kinase ACZ76_08910 ENOG4108ZXC Two component transcriptional regulator, luxr family ACZ76_08920 ENOG4105C7N Xanthine uracil vitamin C permease ACZ76_08925 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 ACZ76_08930 ENOG4105DRP amino acid AbC transporter ACZ76_08935 ENOG4105EAD ABC transporter ACZ76_08940 ENOG4106PMH Extracellular solute-binding protein family 3 ACZ76_08960 ENOG4105E2Z phosphate ABC transporter (Permease ACZ76_08965 ENOG4105C8U phosphate abc transporter ACZ76_08970 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ACZ76_08975 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ACZ76_08980 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ACZ76_08985 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ACZ76_08990 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ACZ76_09000 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ACZ76_09005 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACZ76_09010 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACZ76_09015 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACZ76_09020 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) ACZ76_09025 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation ACZ76_09030 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ACZ76_09035 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ACZ76_09040 ENOG4105QTB Flavodoxin ACZ76_09045 ENOG4108VVK transcriptional Regulator, AsnC ACZ76_09050 ENOG4105CU9 asparagine synthetase A ACZ76_09060 ENOG4105EV2 VWA domain protein interacting with AAA ATPase ACZ76_09065 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) ACZ76_09075 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ACZ76_09080 ENOG4105C2J ABC transporter ACZ76_09085 ENOG4105CNN ABC, transporter ACZ76_09090 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ACZ76_09095 ENOG4108RVA ribokinase ACZ76_09100 ENOG4105ETE Transcriptional regulator (LacI family ACZ76_09105 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACZ76_09110 ENOG4107EJG GntR family transcriptional regulator ACZ76_09135 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b ACZ76_09145 ENOG4105PC1 Conserved Protein ACZ76_09150 ENOG4105E27 serine threonine protein kinase ACZ76_09155 ENOG4108Z33 Thiol disulfide Interchange Protein ACZ76_09160 ENOG4105C2M dna polymerase I ACZ76_09165 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ACZ76_09170 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) ACZ76_09175 ENOG4105D4P Coproporphyrinogen iii oxidase ACZ76_09180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACZ76_09185 ENOG4105CUX Signal transduction histidine kinase ACZ76_09190 ENOG4105C5F glutamine synthetase ACZ76_09200 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 ACZ76_09205 ENOG4107S2Z UPF0761 membrane protein ACZ76_09210 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ACZ76_09215 ENOG4105SUU thioesterase domain ACZ76_09230 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACZ76_09245 ENOG4105HVQ Regulatory factor of maltose metabolism ACZ76_09270 ENOG4105JV1 AsmA family ACZ76_09275 ENOG4105C2W permease ACZ76_09280 ENOG4105D6U Sodium Glutamate Symporter ACZ76_09285 ENOG4105CB5 ATP-dependent DNA helicase recG ACZ76_09290 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase ACZ76_09295 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACZ76_09300 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ACZ76_09310 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) ACZ76_09315 ENOG4105EN6 Membrane ACZ76_09325 ENOG4105D9N nucleoside ACZ76_09330 ENOG4105E39 Enoyl-CoA hydratase ACZ76_09335 ENOG4105BZU Histidine kinase ACZ76_09340 ENOG4105CGP Urocanate hydratase ACZ76_09345 ENOG4105C84 Histidine ammonia-lyase ACZ76_09350 ENOG4105C85 amino acid ACZ76_09360 ENOG4108ZHJ Organic hydroperoxide resistance protein ACZ76_09365 ENOG4105DIJ Phosphoethanolamine transferase ACZ76_09370 ENOG4108KX4 response regulator ACZ76_09375 ENOG4105BZU Histidine kinase ACZ76_09380 ENOG4105CXY transporter ACZ76_09390 ENOG4105D5K Hemolysin activator protein ACZ76_09395 ENOG4105CKT filamentous hemagglutinin ACZ76_09400 ENOG4105DEF Extracellular solute-binding protein, family 5 ACZ76_09405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACZ76_09410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACZ76_09415 ENOG4105C3U ABC transporter ACZ76_09420 ENOG4108JQ7 (ABC) transporter ACZ76_09425 ENOG4105D1V cellulose synthase operon protein YhjU ACZ76_09430 ENOG4105WQA Cellulose biosynthesis protein BcsF ACZ76_09435 ENOG4105U74 cellulose biosynthesis protein BcsE ACZ76_09445 ENOG4105UTS cellulose synthase operon protein YhjQ ACZ76_09450 ENOG4107QZ7 Cellulose synthase catalytic subunit ACZ76_09455 ENOG4107EEX Cellulose synthase regulator protein ACZ76_09460 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) ACZ76_09465 ENOG4105EJG cellulose synthase ACZ76_09470 ENOG4105BZU Histidine kinase ACZ76_09475 ENOG4108PU9 oligogalacturonate-specific porin ACZ76_09485 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) ACZ76_09490 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ACZ76_09495 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ACZ76_09505 ENOG4105KDC 50s ribosomal protein l28 ACZ76_09510 ENOG4105W0E 50S ribosomal protein L33 ACZ76_09530 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ACZ76_09535 ENOG4105D16 lipopolysaccharide heptosyltransferase i ACZ76_09540 ENOG4105XA0 heptosyltransferase ii ACZ76_09545 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) ACZ76_09550 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ACZ76_09560 ENOG4105PXI polysaccharide deacetylase ACZ76_09565 ENOG41063SB peptidase ACZ76_09570 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACZ76_09575 ENOG4107YZP Rhodanese domain protein ACZ76_09580 ENOG4105VW4 glutaredoxin 3 ACZ76_09585 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) ACZ76_09590 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ACZ76_09595 ENOG4105D7W serine acetyltransferase ACZ76_09600 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ACZ76_09605 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ACZ76_09610 ENOG4105E0F Histidine kinase ACZ76_09615 ENOG4105E3W Two component transcriptional regulator (Winged helix family ACZ76_09620 ENOG4105FMW periplasmic ACZ76_09625 ENOG41076HS cation diffusion facilitator family transporter ACZ76_09635 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ACZ76_09650 ENOG4105EBK exported protein ACZ76_09655 ENOG4108VTS Membrane ACZ76_09660 ENOG4105SYT Methylenetetrahydrofolate reductase ACZ76_09665 ENOG4105CFH Aspartokinase ACZ76_09670 ENOG4105C28 cystathionine ACZ76_09675 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) ACZ76_09680 ENOG4105VFB Binds the 23S rRNA (By similarity) ACZ76_09685 ENOG4105C25 Primosomal protein n' ACZ76_09690 ENOG4105ETE Transcriptional regulator (LacI family ACZ76_09695 ENOG41063M6 Cell Division Protein ACZ76_09700 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ACZ76_09705 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ACZ76_09710 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ACZ76_09715 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ACZ76_09720 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) ACZ76_09725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ACZ76_09730 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACZ76_09735 ENOG4105CBT Fructose-1,6-bisphosphatase ACZ76_09740 ENOG4105E5M Multidrug resistance protein D ACZ76_09745 ENOG4105DP0 ferredoxin-NADP reductase ACZ76_09750 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) ACZ76_09760 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ACZ76_09765 ENOG4105CAS nag kinase ACZ76_09770 ENOG4105CH7 arginosuccinase ACZ76_09795 ENOG4107QZV Type I secretion membrane fusion protein ACZ76_09805 ENOG4107QN2 dihydrolipoyl dehydrogenase ACZ76_09810 ENOG4105EHV domain protein ACZ76_09815 ENOG4105C5Q Transcriptional regulator ACZ76_09820 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) ACZ76_09825 ENOG4105EJ2 Transcriptional regulator ACZ76_09830 ENOG4108Y73 Membrane ACZ76_09835 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) ACZ76_09845 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ACZ76_09885 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator ACZ76_09890 ENOG4105C2J ABC transporter ACZ76_09895 ENOG4107R9N ABC transporter ACZ76_09900 ENOG41062B0 ABC transporter, permease ACZ76_09905 ENOG4105CVI Transcriptional regulator ACZ76_09910 ENOG4108WFC UPF0438 protein yifE ACZ76_09915 ENOG4105C0P Mg chelatase subunit ChlI ACZ76_09925 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit ACZ76_09930 ENOG4105CM2 brancheD-chain amino acid aminotransferase ACZ76_09935 ENOG4105C01 Dihydroxy-acid dehydratase ACZ76_09940 ENOG4105C7B Threonine dehydratase ACZ76_09955 ENOG4105EMY transcriptional regulator ACZ76_09960 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ACZ76_09970 ENOG4108MA7 Inherit from COG: YD repeat protein ACZ76_09985 ENOG41060S4 immunity protein ACZ76_10000 ENOG4108VEV chaperone ACZ76_10010 ENOG4105CW0 outer membrane usher protein ACZ76_10015 ENOG4108MQF Chaperone ACZ76_10025 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ACZ76_10030 ENOG4105C4R Atp-dependent dna helicase ACZ76_10040 ENOG4105C9X ppx gppa phosphatase ACZ76_10050 ENOG4105K63 Thioredoxin ACZ76_10060 ENOG4105ESV Glycosyl transferase, family 4 ACZ76_10065 ENOG4105SFE lipopolysaccharide biosynthesis protein ACZ76_10070 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ACZ76_10075 ENOG4108IJ1 Dehydrogenase ACZ76_10080 ENOG4105C1B dTDP-glucose 4-6-dehydratase ACZ76_10085 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ACZ76_10090 ENOG4108WJ1 acetyltransferase ACZ76_10095 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACZ76_10100 ENOG4105EGZ biosynthesis protein ACZ76_10105 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) ACZ76_10120 ENOG4105C85 amino acid ACZ76_10145 ENOG410601J HemY protein ACZ76_10150 ENOG4105ECF c-methyltransferase ACZ76_10155 ENOG41076E6 Uroporphyrinogen-III Synthase ACZ76_10160 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ACZ76_10170 ENOG4105XQ6 frataxin-like protein ACZ76_10175 ENOG4105S7Z (LipO)protein ACZ76_10180 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ACZ76_10185 ENOG4105CT0 Protein of unknown function, DUF484 ACZ76_10190 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACZ76_10195 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ACZ76_10200 ENOG4105C4R Atp-dependent dna helicase ACZ76_10210 ENOG4105EQN UPF0261 protein ACZ76_10225 ENOG4107QUT magnesium and cobalt transport protein CorA ACZ76_10230 ENOG4105FR1 rard protein ACZ76_10235 ENOG4108VUY thioesterase Superfamily protein ACZ76_10240 ENOG4105HDD phospholipase ACZ76_10245 ENOG4105C9U ATP-dependent DNA helicase RecQ ACZ76_10250 ENOG4105CCF Lysine exporter protein (Lyse ygga) ACZ76_10255 ENOG410829K Lysine exporter protein (Lyse ygga) ACZ76_10260 ENOG4108EUD Lysophospholipase ACZ76_10265 ENOG4105DQF Hydrolase ACZ76_10270 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ACZ76_10275 ENOG4105CXY transporter ACZ76_10280 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ACZ76_10290 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ACZ76_10295 ENOG4108W1V Lipoprotein ACZ76_10300 ENOG4105EX9 Membrane ACZ76_10305 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ACZ76_10315 ENOG4107FS9 Membrane ACZ76_10330 ENOG4105MG3 Membrane ACZ76_10335 ENOG4106H78 methyltransferase ACZ76_10340 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ACZ76_10340 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ACZ76_10345 ENOG4105CAK Cell division ATP-binding protein ftsE ACZ76_10350 ENOG4105CRP Part of the ABC transporter FtsEX involved in ACZ76_10360 ENOG4105U59 -acetyltransferase ACZ76_10365 ENOG4105CP9 extracellular ligand-binding receptor ACZ76_10370 ENOG4105C32 Amino acid ABC transporter (Permease) ACZ76_10375 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ACZ76_10380 ENOG4105C0Z ABC transporter ACZ76_10385 ENOG4108IV0 ABC, transporter ACZ76_10430 ENOG4105BZ7 extracellular solute-binding protein family 1 ACZ76_10435 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component ACZ76_10440 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component ACZ76_10445 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACZ76_10450 ENOG4107T6V glycerophosphoryl diester phosphodiesterase ACZ76_10455 ENOG4105RK9 auxin efflux carrier ACZ76_10465 ENOG4105EMK carboxylate amino acid amine transporter ACZ76_10470 ENOG4105DZ2 Transcriptional regulator ACZ76_10475 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ACZ76_10480 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) ACZ76_10485 ENOG4108I5U Uridine phosphorylase ACZ76_10500 ENOG4108KF1 Membrane ACZ76_10505 ENOG4105CGY Dna recombination protein ACZ76_10510 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACZ76_10515 ENOG4105JC1 sterol-binding domain protein ACZ76_10520 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) ACZ76_10525 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ACZ76_10530 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ACZ76_10535 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ACZ76_10545 ENOG4105D52 delta-aminolevulinic acid dehydratase ACZ76_10550 ENOG4105MDZ Transcriptional activator rfaH ACZ76_10555 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ACZ76_10560 ENOG4107QK7 reductase ACZ76_10565 ENOG4105CHU acetyl-coa acetyltransferase ACZ76_10570 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ACZ76_10580 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ACZ76_10585 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ACZ76_10590 ENOG4108RR8 protoporphyrinogen oxidase ACZ76_10620 ENOG4107QN1 sodium solute ACZ76_10625 ENOG41062QD Membrane ACZ76_10630 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ACZ76_10635 ENOG4105CK2 sodium dicarboxylate symporter ACZ76_10645 ENOG4105BZU Histidine kinase ACZ76_10685 ENOG4108SZ7 secretion system effector ACZ76_10745 ENOG4105UQF type iii secretion ACZ76_10760 ENOG4108JIR Flagellum-specific ATP synthase ACZ76_10780 ENOG4108HHI Type III secretion system protein ACZ76_10785 ENOG41083GP type iii secretion ACZ76_10790 ENOG4108TN6 type iii secretion ACZ76_10795 ENOG4108IUF type iii secretion ACZ76_10805 ENOG4105EGS Mechanosensitive ion channel ACZ76_10810 ENOG4105E0K tonB-dependent siderophore receptor ACZ76_10820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACZ76_10825 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) ACZ76_10830 ENOG4105EHG Permease protein ACZ76_10835 ENOG4107R4I Periplasmic binding protein ACZ76_10840 ENOG4106QJH hemin transport protein ACZ76_10845 ENOG4107ENK receptor ACZ76_10860 ENOG41090JE Utilization Protein ACZ76_10865 ENOG4105D4P Coproporphyrinogen iii oxidase ACZ76_10870 ENOG4107QZ7 Cellulose synthase catalytic subunit ACZ76_10905 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACZ76_10910 ENOG4105FAW cDP-glucose 4,6-dehydratase ACZ76_10915 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ACZ76_10920 ENOG4108EX3 reductase ACZ76_10930 ENOG4105F9F transposase ACZ76_10935 ENOG4105D4P Coproporphyrinogen iii oxidase ACZ76_10945 ENOG4108SIC Transcriptional regulator ACZ76_10950 ENOG4105CNV Aldolase ACZ76_10955 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ACZ76_10960 ENOG4105BZW Glycerate kinase ACZ76_10965 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ACZ76_10970 ENOG4105CTX dehydratase ACZ76_10975 ENOG4105DJB Major Facilitator Superfamily ACZ76_10980 ENOG4105BZ8 glutamate synthase ACZ76_10985 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ACZ76_11010 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ACZ76_11015 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ACZ76_11020 ENOG4108ZVF (LipO)protein ACZ76_11025 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ACZ76_11040 ENOG4105KPY Small multidrug resistance protein ACZ76_11050 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ACZ76_11055 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) ACZ76_11070 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) ACZ76_11075 ENOG4105EGS Mechanosensitive ion channel ACZ76_11080 ENOG4105DJ4 phosphatidylserine decarboxylase ACZ76_11085 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ACZ76_11090 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ACZ76_11110 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ACZ76_11115 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ACZ76_11120 ENOG4105K8N protein family UPF0079, ATPase ACZ76_11125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ACZ76_11130 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ACZ76_11140 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ACZ76_11145 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ACZ76_11150 ENOG4107QJR hflk protein ACZ76_11155 ENOG4105EPW hflc protein ACZ76_11165 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ACZ76_11170 ENOG4105KPV Transcriptional regulator ACZ76_11175 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ACZ76_11180 ENOG4105C2N RNA methyltransferase TrmH family group 3 ACZ76_11185 ENOG4105CSU acyl-Coa dehydrogenase ACZ76_11190 ENOG4105WSB biofilm stress and motility protein A ACZ76_11195 ENOG4108MXZ Esterase ACZ76_11200 ENOG4105RID UPF0379 protein yhcN ACZ76_11205 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ACZ76_11215 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ACZ76_11230 ENOG4105FHY Opacity-associated protein A ACZ76_11235 ENOG4108V1T peptidylprolyl cis-trans isomerase ACZ76_11245 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic ACZ76_11250 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ACZ76_11255 ENOG4108UUE Transcriptional regulator ACZ76_11260 ENOG41061GZ Protein of unknown function (DUF1107) ACZ76_11265 ENOG4105C37 (CBS) domain ACZ76_11270 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ACZ76_11280 ENOG4105MA0 exported protein ACZ76_11285 ENOG4108ZHD aig2 family ACZ76_11310 ENOG4105CG5 Glycosyl transferase (Group 1 ACZ76_11330 ENOG4105F0N pyrophosphate phospho-hydrolase ACZ76_11335 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_11340 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 ACZ76_11345 ENOG4105DFU Cell wall formation (By similarity) ACZ76_11365 ENOG4105HVQ Regulatory factor of maltose metabolism ACZ76_11375 ENOG4105EAH synthase ACZ76_11390 ENOG4105QYV Membrane ACZ76_11400 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ACZ76_11415 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ACZ76_11420 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ACZ76_11425 ENOG4105HBR Rna-binding protein ACZ76_11430 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ACZ76_11435 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACZ76_11440 ENOG4105EEI dihydropteroate synthase ACZ76_11470 ENOG4105CHV Transcription elongation factor NusA ACZ76_11480 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ACZ76_11485 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ACZ76_11495 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ACZ76_11505 ENOG4105C1J atp-dependent rna helicase ACZ76_11515 ENOG4105DEN Luciferase family ACZ76_11525 ENOG4105C44 Serine transporter ACZ76_11530 ENOG4105CEM UPF0597 protein ACZ76_11535 ENOG4106RZ4 Peptidase U32 ACZ76_11540 ENOG4105CFP Peptidase U32 ACZ76_11545 ENOG4105XPQ lipid carrier protein ACZ76_11550 ENOG4108YYD acetyltransferase ACZ76_11555 ENOG41082IR Excinuclease ABC C subunit domain protein ACZ76_11560 ENOG4105D5Q Arginine ornithine antiporter ACZ76_11565 ENOG4105CXN decarboxylase ACZ76_11570 ENOG4105EY3 heparinase II III family protein ACZ76_11585 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component ACZ76_11590 ENOG4105DRS transport system, permease ACZ76_11605 ENOG4108ZPB UPF0306 protein ACZ76_11610 ENOG4105K4T epimerase ACZ76_11615 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein ACZ76_11620 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) ACZ76_11625 ENOG4105FD8 phosphonate metabolism protein PhnM ACZ76_11630 ENOG4105HRV phosphonate c-p lyase system protein phnl ACZ76_11635 ENOG4105ENV phosphonate C-P lyase system protein PhnK ACZ76_11640 ENOG4105FT8 Phosphonate metabolism ACZ76_11645 ENOG4105EKV Phosphonate metabolism protein ACZ76_11650 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH ACZ76_11655 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG ACZ76_11660 ENOG4107RJJ Transcriptional regulator ACZ76_11675 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ACZ76_11680 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ACZ76_11695 ENOG4108JQ7 (ABC) transporter ACZ76_11700 ENOG4105C3U ABC transporter ACZ76_11705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACZ76_11710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACZ76_11720 ENOG4105XEP YhcH YjgK YiaL family protein ACZ76_11730 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) ACZ76_11735 ENOG4108MJ3 acetyltransferase ACZ76_11745 ENOG4105MYG DNA polymerase iii, chi subunit ACZ76_11750 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ACZ76_11755 ENOG4108M8S permease YjgP YjgQ family protein ACZ76_11760 ENOG4108K5H permease YjgP YjgQ family protein ACZ76_11770 ENOG4105PBD transposase, IS3 IS911 family protein ACZ76_11775 ENOG4105F9F transposase ACZ76_11800 ENOG4105HVQ Regulatory factor of maltose metabolism ACZ76_11810 ENOG4105RI1 glycoprotein receptor ACZ76_11825 ENOG4105D4B ABC, transporter ACZ76_11830 ENOG4105F5R ABC transporter ACZ76_11835 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane ACZ76_11840 ENOG4105C2J ABC transporter ACZ76_11845 ENOG4105DKT Transcriptional regulator ACZ76_11850 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) ACZ76_11855 ENOG4105DKP glycosyl transferase, family 9 ACZ76_11865 ENOG4105D5Q Arginine ornithine antiporter ACZ76_11870 ENOG4105CEU Arginine dihydrolase ACZ76_11875 ENOG410624X efflux transporter, rnd family, mfp subunit ACZ76_11880 ENOG4105BZS acriflavin resistance protein ACZ76_11890 ENOG4105CMT Dihydroxyacetone kinase ACZ76_11895 ENOG4108UTZ Dihydroxyacetone kinase ACZ76_11900 ENOG4105VDH Dihydroxyacetone kinase ACZ76_11945 ENOG4105GAV receptor ACZ76_11950 ENOG4105BZU Histidine kinase ACZ76_11955 ENOG4105YBH Protein of unknown function (DUF1435) ACZ76_11980 ENOG4105CPC Aldo Keto reductase ACZ76_11985 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ACZ76_11990 ENOG4108WPU DNA polymerase III subunit psi ACZ76_11995 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ACZ76_12000 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ACZ76_12005 ENOG4105K3G Periplasmic Protein ACZ76_12010 ENOG4108NRW Phospholipase, patatin family ACZ76_12015 ENOG4105EYA deoxyribonuclease ACZ76_12020 ENOG4105D9N nucleoside ACZ76_12025 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ACZ76_12035 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ACZ76_12045 ENOG4105EUP HipA domain protein ACZ76_12050 ENOG41062Z9 Membrane ACZ76_12055 ENOG4105EAC phosphoserine phosphatase ACZ76_12060 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ACZ76_12065 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase ACZ76_12070 ENOG4105CIS alcohol dehydrogenase ACZ76_12075 ENOG4105CC0 LysR family Transcriptional regulator ACZ76_12085 ENOG4105C5H ABC transporter ACZ76_12090 ENOG41090EK ompa motb domain protein ACZ76_12095 ENOG4108KHX Diguanylate cyclase ACZ76_12110 ENOG4107SC1 transglycosylase ACZ76_12115 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) ACZ76_12120 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ACZ76_12130 ENOG4105UEI Transcriptional Regulator AraC Family ACZ76_12135 ENOG4108RH0 Crea protein ACZ76_12140 ENOG41065U4 response regulator ACZ76_12145 ENOG4105F9F transposase ACZ76_12155 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ACZ76_12165 ENOG4105D1Q UPF0246 protein ACZ76_12170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ACZ76_12175 ENOG4108RIR Molybdenum cofactor biosynthesis protein ACZ76_12180 ENOG4105CSH Transporter ACZ76_12190 ENOG4106HK8 GPR1 FUN34 yaaH family protein ACZ76_12200 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ACZ76_12205 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ACZ76_12210 ENOG41063Z6 transcriptional regulator, lysR family ACZ76_12220 ENOG4105DTN riboflavin biosynthesis protein ribF ACZ76_12225 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ACZ76_12230 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ACZ76_12235 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ACZ76_12240 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ACZ76_12245 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ACZ76_12250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ACZ76_12255 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ACZ76_12260 ENOG4105N14 lysine exporter protein LysE YggA ACZ76_12265 ENOG4105DWK Membrane ACZ76_12275 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) ACZ76_12280 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ACZ76_12285 ENOG4105NWN ApaG protein ACZ76_12290 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ACZ76_12300 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ACZ76_12305 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ACZ76_12310 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ACZ76_12320 ENOG4105D3G Pseudouridine synthase ACZ76_12330 ENOG4105CQ2 DNA polymerase ACZ76_12335 ENOG4108KF1 Membrane ACZ76_12345 ENOG4106SMU thiamine transporter membrane protein ACZ76_12350 ENOG4105DP9 ABC transporter ACZ76_12355 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ACZ76_12360 ENOG4105F1A Pyruvate formate-lyase ACZ76_12365 ENOG4105C6N Formate acetyltransferase ACZ76_12370 ENOG4105S8Q sugar efflux transporter ACZ76_12380 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ACZ76_12385 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ACZ76_12395 ENOG41064T2 transcriptional regulator, lysR family ACZ76_12400 ENOG4108IQE Amp-dependent synthetase and ligase ACZ76_12405 ENOG4105C7K acetolactate synthase ACZ76_12410 ENOG4108ZP8 Acetolactate synthase small subunit ACZ76_12415 ENOG4107B7Y DNA-binding transcriptional regulator FruR ACZ76_12430 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ACZ76_12435 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ACZ76_12440 ENOG4105CJN penicillin-binding protein ACZ76_12445 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ACZ76_12450 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ACZ76_12455 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ACZ76_12465 ENOG4105CNI cell division protein FtsW ACZ76_12470 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ACZ76_12475 ENOG4105DFU Cell wall formation (By similarity) ACZ76_12485 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ACZ76_12490 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ACZ76_12495 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ACZ76_12510 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) ACZ76_12515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving ACZ76_12520 ENOG4105M6F mutator MutT protein ACZ76_12525 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ACZ76_12535 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ACZ76_12540 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ACZ76_12545 ENOG4105D7Q type ii secretion system ACZ76_12550 ENOG4107QHF type ii secretion system protein e ACZ76_12555 ENOG4108ZUW Major pilin subunit ACZ76_12560 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ACZ76_12565 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ACZ76_12570 ENOG4106A72 regulatory protein AmpE ACZ76_12575 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) ACZ76_12580 ENOG4105CT4 transporter ACZ76_12585 ENOG4105C85 amino acid ACZ76_12590 ENOG41073TP transcriptional regulator ACZ76_12595 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ACZ76_12600 ENOG4107QSN dihydrolipoamide acetyltransferase ACZ76_12605 ENOG4107QN2 dihydrolipoyl dehydrogenase ACZ76_12620 ENOG4107RNH Outer membrane receptor FepA ACZ76_12625 ENOG4107QIJ Aconitate hydratase 2 ACZ76_12630 ENOG4108ZIG UPF0231 protein ACZ76_12635 ENOG4105RPH Inner membrane protein YddG ACZ76_12665 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) ACZ76_12670 ENOG4108ZRK uncharacterized protein yacC ACZ76_12675 ENOG4105E3B Multicopper oxidase ACZ76_12685 ENOG4108UGV hypoxanthine phosphoribosyltransferase ACZ76_12690 ENOG41077A9 carbonic anhydrase ACZ76_12695 ENOG4105DA5 (ABC) transporter ACZ76_12700 ENOG4105E3A (ABC) transporter ACZ76_12705 ENOG4107BJW polysaccharide deacetylase ACZ76_12710 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ACZ76_12715 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ACZ76_12720 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ACZ76_12725 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ACZ76_12730 ENOG4105DJ0 Poly(A) Polymerase ACZ76_12740 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ACZ76_12745 ENOG4105PW4 Sugar fermentation stimulation protein homolog ACZ76_12750 ENOG4107XID 2'-5' rna ligase ACZ76_12755 ENOG4105CQ7 ATP-dependent helicase ACZ76_12760 ENOG4105BZ4 penicillin-binding protein ACZ76_12765 ENOG4105E0A ABC, transporter ACZ76_12770 ENOG4105J76 Periplasmic binding protein ACZ76_12775 ENOG4105S6R Iron-hydroxamate transporter permease subunit ACZ76_12785 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ACZ76_12795 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ACZ76_12805 ENOG4105EN6 Membrane ACZ76_12815 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ACZ76_12820 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein ACZ76_12825 ENOG4105C0H protease ACZ76_12830 ENOG4105BZU Histidine kinase ACZ76_12835 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ACZ76_12840 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACZ76_12845 ENOG4105DXN mazG family ACZ76_12850 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ACZ76_12855 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ACZ76_12865 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ACZ76_12870 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ACZ76_12875 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ACZ76_12880 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ACZ76_12885 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ACZ76_12900 ENOG4108MXK alkaline phosphatase isozyme conversion ACZ76_12905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ACZ76_12910 ENOG4105C11 sulfate adenylyltransferase), subunit 2 ACZ76_12915 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) ACZ76_12920 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) ACZ76_12925 ENOG4105N0Z inner membrane protein ygbE ACZ76_12930 ENOG4108YZG isomerase ACZ76_12935 ENOG4105CPQ Dehydrogenase ACZ76_12940 ENOG4105IE8 Alpha-ketoglutarate permease ACZ76_12945 ENOG4105CHR reductase ACZ76_12950 ENOG4105CMT Dihydroxyacetone kinase ACZ76_12955 ENOG4108UTZ Dihydroxyacetone kinase ACZ76_12960 ENOG4105DKT Transcriptional regulator ACZ76_12970 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ACZ76_12980 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ACZ76_12985 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) ACZ76_12990 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ACZ76_12995 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ACZ76_13000 ENOG4108K5P (LipO)protein ACZ76_13005 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACZ76_13010 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ACZ76_13030 ENOG4108RQP Major type 1 subunit fimbrin ACZ76_13035 ENOG4106PG1 outer membrane usher protein ACZ76_13040 ENOG4108FZ9 Chaperone ACZ76_13050 ENOG4105UGQ Fimbrial ACZ76_13080 ENOG4108JJA ABC, transporter ACZ76_13085 ENOG4105DJY efflux transporter, rnd family, mfp subunit ACZ76_13095 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ACZ76_13100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACZ76_13115 ENOG4105CHR reductase ACZ76_13120 ENOG4105E89 ABC transporter ACZ76_13125 ENOG4105CXK mandelate racemase muconate lactonizing ACZ76_13135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ACZ76_13140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACZ76_13150 ENOG4108JQ7 (ABC) transporter ACZ76_13155 ENOG4105EAB amino acid AbC transporter ACZ76_13160 ENOG4105E5Q amino acid AbC transporter ACZ76_13165 ENOG4105E5Q amino acid AbC transporter ACZ76_13170 ENOG4105CDA abc transporter atp-binding protein ACZ76_13175 ENOG4105CE7 Amidase, hydantoinase carbamoylase family ACZ76_13190 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ACZ76_13195 ENOG4105YVS arsR family transcriptional regulator ACZ76_13210 ENOG4107GFK fumarate ACZ76_13215 ENOG4107EDW L-fucose operon activator ACZ76_13225 ENOG4105CMG Carbohydrate kinase ACZ76_13235 ENOG4105EDR glucose galactose transporter ACZ76_13240 ENOG4107W7X Aldolase ACZ76_13245 ENOG4105C0A alcohol dehydrogenase ACZ76_13250 ENOG4107QY8 reductase ACZ76_13255 ENOG4105QAX Iron-sulfur ACZ76_13260 ENOG4107KGK dmso reductase anchor subunit ACZ76_13265 ENOG4108NEM leader-binding protein dmsD ACZ76_13290 ENOG4105C2J ABC transporter ACZ76_13295 ENOG4105CNN ABC, transporter ACZ76_13300 ENOG4108HHA Transketolase ACZ76_13305 ENOG4108IUS Transketolase ACZ76_13310 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACZ76_13335 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ACZ76_13340 ENOG4105Y3E Modulates RecA activity (By similarity) ACZ76_13345 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ACZ76_13350 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ACZ76_13375 ENOG4107VXZ Hydrolase ACZ76_13380 ENOG4105W39 Membrane ACZ76_13385 ENOG4105D9M gamma-glutamylcysteine synthetase ACZ76_13390 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ACZ76_13395 ENOG4108JU6 CBS domain protein ACZ76_13400 ENOG4106KVJ cytochrome C assembly protein ACZ76_13405 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ACZ76_13415 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ACZ76_13425 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ACZ76_13430 ENOG4108NE3 Salt-induced outer membrane protein ACZ76_13435 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ACZ76_13440 ENOG4108NEV two component transcriptional regulator, LytTR family ACZ76_13445 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACZ76_13455 ENOG4105CQC Prephenate dehydratase ACZ76_13460 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ACZ76_13465 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ACZ76_13470 ENOG4105C34 Pseudouridine synthase ACZ76_13475 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ACZ76_13480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACZ76_13515 ENOG4105JIM Phosphatidylserine synthase ACZ76_13520 ENOG4105CD5 CoA-binding domain protein ACZ76_13525 ENOG4106IUH DTW domain containing protein ACZ76_13530 ENOG4105K63 Thioredoxin ACZ76_13535 ENOG4105EIB trna rrna methyltransferase ACZ76_13540 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACZ76_13545 ENOG4105CW7 secretion protein, HlyD family ACZ76_13550 ENOG4105ETP RND efflux system, outer membrane lipoprotein ACZ76_13555 ENOG4105NTK Transcriptional repressor Mpra ACZ76_13560 ENOG4105ZED uncharacterized protein ygaH ACZ76_13565 ENOG4108UMN azlc family ACZ76_13570 ENOG4105EQ0 Major Facilitator superfamily ACZ76_13575 ENOG4105C5R Aminotransferase ACZ76_13585 ENOG4105CHM Aminotransferase ACZ76_13590 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) ACZ76_13600 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) ACZ76_13610 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) ACZ76_13625 ENOG4106YJS accessory processing protein ACZ76_13630 ENOG4107QPN acyl-Coa dehydrogenase ACZ76_13640 ENOG4105E7A Glutamine amidotransferase ACZ76_13645 ENOG4105F7V ErfK ybiS ycfS ynhG family protein ACZ76_13650 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACZ76_13655 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACZ76_13660 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACZ76_13665 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACZ76_13670 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) ACZ76_13675 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) ACZ76_13680 ENOG4105CJ2 (LipO)protein ACZ76_13695 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ACZ76_13700 ENOG4105CIN aminoacyl-histidine dipeptidase ACZ76_13710 ENOG4105V1F Fermentation respiration switch protein ACZ76_13715 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) ACZ76_13720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ACZ76_13725 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ACZ76_13745 ENOG4105F2W methyltransferase ACZ76_13770 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ACZ76_13775 ENOG4105NBK UPF0345 protein ACZ76_13780 ENOG4105DH7 May be involved in recombination (By similarity) ACZ76_13785 ENOG4105DKQ ROK family ACZ76_13790 ENOG4105EYH Exonuclease ACZ76_13795 ENOG4107RH8 nuclease SbcCD subunit D ACZ76_13800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACZ76_13805 ENOG4105BZU Histidine kinase ACZ76_13815 ENOG4105CWM branched-chain amino acid transport system II carrier protein ACZ76_13820 ENOG4105C85 amino acid ACZ76_13825 ENOG4107R28 alpha amylase, catalytic region ACZ76_13830 ENOG4105CHR reductase ACZ76_13840 ENOG4105D3R alkyl hydroperoxide reductase ACZ76_13845 ENOG4108ZYK Acyl carrier protein phosphodiesterase ACZ76_13850 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ACZ76_13855 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ACZ76_13860 ENOG4105VIE preprotein translocase, subunit YajC ACZ76_13865 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ACZ76_13870 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ACZ76_13885 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ACZ76_13890 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ACZ76_13895 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ACZ76_13905 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ACZ76_13910 ENOG4108ZAI phosphatidylglycerophosphatase a ACZ76_13915 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ACZ76_13920 ENOG4105CTB Polyprenyl synthetase ACZ76_13925 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ACZ76_13930 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ACZ76_13935 ENOG4107S0N DJ-1 family ACZ76_13940 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ACZ76_13945 ENOG4108VPT UPF0234 protein ACZ76_13950 ENOG4107RDB Major Facilitator ACZ76_13955 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ACZ76_13960 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) ACZ76_13965 ENOG4105CCU oxidase (Subunit III) ACZ76_13970 ENOG4105BZ9 Cytochrome C oxidase, subunit I ACZ76_13975 ENOG4105E2S oxidase) subunit II ACZ76_13980 ENOG4108NFH Sugar hydrolase ACZ76_13985 ENOG4105EYM Major Facilitator superfamily ACZ76_13990 ENOG4105IEY (LipO)protein ACZ76_13995 ENOG4105M85 Bola protein ACZ76_14000 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ACZ76_14005 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACZ76_14010 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ACZ76_14015 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ACZ76_14020 ENOG4105K70 DNA-binding protein ACZ76_14025 ENOG4105EIN peptidylprolyl cis-trans isomerase ACZ76_14030 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ACZ76_14035 ENOG4108TGP Thioesterase superfamily protein ACZ76_14040 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ACZ76_14045 ENOG4108NFA extracellular solute-binding protein ACZ76_14050 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) ACZ76_14060 ENOG4108XM1 transcriptional regulator AsnC family ACZ76_14065 ENOG4105BZ1 (ABC) transporter ACZ76_14070 ENOG4105BZ1 (ABC) transporter ACZ76_14075 ENOG4108YZA Nitrogen regulatory protein pii ACZ76_14080 ENOG4105BZU Histidine kinase ACZ76_14085 ENOG4105C29 acyl-CoA thioesterase ACZ76_14090 ENOG4108MNP Glycoprotein polysaccharide metabolism ACZ76_14095 ENOG41080UX Methyltransferase ACZ76_14100 ENOG4105KF5 hemolysin expression-modulating protein ACZ76_14105 ENOG4108UKR Biofilm formation regulator YbaJ ACZ76_14115 ENOG4105DIK (ABC) transporter ACZ76_14120 ENOG4105CC5 ABC transporter ACZ76_14125 ENOG4105DSE periplasmic solute binding protein ACZ76_14130 ENOG4105NRA 50s ribosomal protein l31 type b ACZ76_14135 ENOG4106M0N transport system permease protein ACZ76_14140 ENOG4105MUZ Protein of unknown function DUF2620 ACZ76_14145 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ACZ76_14150 ENOG4108626 Racemase ACZ76_14160 ENOG4105BZS acriflavin resistance protein ACZ76_14165 ENOG4105C1P efflux transporter, rnd family, mfp subunit ACZ76_14170 ENOG4108IG5 Transcriptional regulator ACZ76_14175 ENOG41090EX DsrE family ACZ76_14180 ENOG4105EGS Mechanosensitive ion channel ACZ76_14190 ENOG4105WD1 Membrane ACZ76_14195 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ACZ76_14200 ENOG4107QMP dna polymerase iii subunits gamma and tau ACZ76_14210 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ACZ76_14215 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ACZ76_14220 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ACZ76_14225 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ACZ76_14250 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACZ76_14280 ENOG4105DMT epimerase dehydratase ACZ76_14290 ENOG4105CMR udp-glucose 4-epimerase ACZ76_14295 ENOG4108QY5 Ferric enterobactin transport protein ACZ76_14300 ENOG4107RE1 Inosine-guanosine kinase ACZ76_14305 ENOG4105CKD glutathione-regulated potassium-efflux system protein ACZ76_14310 ENOG4105EU0 Major facilitator Superfamily ACZ76_14315 ENOG4105CGH 5'-nucleotidase ACZ76_14320 ENOG4108Z66 YbaK ebsC protein ACZ76_14325 ENOG4105MBR gumn family ACZ76_14330 ENOG4105C59 p-type ATPase ACZ76_14335 ENOG4108Z6Z Transcriptional regulator ACZ76_14340 ENOG4105G5H Membrane ACZ76_14345 ENOG4107QX8 SPFH domain, Band 7 family protein ACZ76_14350 ENOG4107QR8 Thioredoxin ACZ76_14355 ENOG4105E1F short-chain dehydrogenase reductase ACZ76_14360 ENOG4108UJV acyl-CoA thioesterase i ACZ76_14365 ENOG4108I0Y (ABC) transporter ACZ76_14370 ENOG4105CV6 ABC transporter, permease ACZ76_14375 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ACZ76_14380 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ACZ76_14385 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) ACZ76_14390 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ACZ76_14395 ENOG4105C8N cysteinyl-tRNA synthetase ACZ76_14400 ENOG4105WQ3 Rna-binding protein ACZ76_14405 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ACZ76_14455 ENOG4105DQ6 Transposase ACZ76_14465 ENOG4105CKT filamentous hemagglutinin ACZ76_14470 ENOG4105D5K Hemolysin activator protein ACZ76_14475 ENOG4108Y83 glucose-6-phosphate isomerase ACZ76_14485 ENOG4105F3R pts system mannose fructose sorbose family iid ACZ76_14490 ENOG4105ETZ PTS System ACZ76_14495 ENOG4108EQA pts system ACZ76_14510 ENOG4107P2S Transcriptional regulator ACZ76_14520 ENOG4105EZE Cupin 4 family protein ACZ76_14525 ENOG4108JJ7 ABC transporter ACZ76_14540 ENOG4108R1E Serine threonine protein phosphatase 1 ACZ76_14550 ENOG4108N8T regulatoR ACZ76_14560 ENOG4105VEQ Cold shock protein ACZ76_14565 ENOG4107Z6W Protein CrcB homolog ACZ76_14570 ENOG4105BZU Histidine kinase ACZ76_14575 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) ACZ76_14580 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ACZ76_14585 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ACZ76_14590 ENOG4108Z43 UPF0250 protein ACZ76_14595 ENOG4105DZ1 carboxypeptidase ACZ76_14600 ENOG4105K6T rare lipoprotein A ACZ76_14605 ENOG4105CNI cell division protein FtsW ACZ76_14610 ENOG4105CJN penicillin-binding protein ACZ76_14620 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ACZ76_14625 ENOG4108I1J Integrase ACZ76_14730 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACZ76_14750 ENOG4105CDU Replicative dna helicase ACZ76_14775 ENOG4105NY2 NinB protein ACZ76_14815 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 ACZ76_14840 ENOG4108N0N Phage Terminase Large Subunit ACZ76_14910 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ACZ76_14915 ENOG4105DJF DNA polymerase III, delta' subunit ACZ76_14920 ENOG4108U2H Rare lipoprotein B ACZ76_14930 ENOG4107PAI alpha helical protein ACZ76_14940 ENOG4105CDA abc transporter atp-binding protein ACZ76_14945 ENOG4105DRP amino acid AbC transporter ACZ76_14950 ENOG4105EAD ABC transporter ACZ76_14955 ENOG4107RP9 extracellular solute-binding protein, family 3 ACZ76_14965 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ACZ76_14970 ENOG4108JU5 Magnesium and cobalt efflux protein ACZ76_14975 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ACZ76_14980 ENOG4105C9A Phoh family ACZ76_14985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ACZ76_14990 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ACZ76_15025 ENOG4105CAQ asparagine synthetase ACZ76_15030 ENOG4105D4U had-superfamily hydrolase, subfamily iia ACZ76_15035 ENOG4105E2R ROK family ACZ76_15040 ENOG4105CE4 GlcNAc 6-P deacetylase ACZ76_15050 ENOG4105CI1 PTS System ACZ76_15055 ENOG4105CX6 glutaminyL-tRNA synthetase ACZ76_15065 ENOG4105GX6 (LipO)protein ACZ76_15085 ENOG41090R7 Ferric uptake ACZ76_15090 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ACZ76_15095 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_15100 ENOG4105NNH LexA regulated protein ACZ76_15105 ENOG4105EV9 Alpha Beta Hydrolase ACZ76_15115 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ACZ76_15130 ENOG4105EEX Two component transcriptional regulator (Winged helix family ACZ76_15135 ENOG4105C08 Histidine kinase ACZ76_15140 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) ACZ76_15145 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ACZ76_15150 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ACZ76_15160 ENOG4105XIQ Protein of unknown function (DUF2517) ACZ76_15165 ENOG4107SEY Conserved Protein ACZ76_15170 ENOG4105CVP deoxyribo-dipyrimidine photolyase ACZ76_15175 ENOG4107RF4 Phosphodiesterase ACZ76_15180 ENOG4107QNR UPF0135 protein ACZ76_15185 ENOG4105P4J Allophanate hydrolase, subunit 1 ACZ76_15190 ENOG4107R7A Allophanate hydrolase subunit 2 ACZ76_15195 ENOG4105E7W lamb ycsf family protein ACZ76_15215 ENOG4105BZN citrate synthase ACZ76_15220 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ACZ76_15225 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ACZ76_15235 ENOG4105E33 succinate dehydrogenase ACZ76_15240 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ACZ76_15245 ENOG4105C7S Dehydrogenase ACZ76_15250 ENOG4105CMV Succinyl-CoA synthetase subunit beta ACZ76_15255 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ACZ76_15260 ENOG4105CGH 5'-nucleotidase ACZ76_15265 ENOG4105C4M (Ubiquinol oxidase) subunit I ACZ76_15270 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ACZ76_15280 ENOG4105KJB cyd operon protein YbgE ACZ76_15285 ENOG4107YD3 Thioesterase ACZ76_15290 ENOG4105E02 MotA TolQ exbB proton channel ACZ76_15295 ENOG4105M8F Biopolymer transport protein exbD tolR ACZ76_15300 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA ACZ76_15300 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA ACZ76_15305 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ACZ76_15310 ENOG4105KCK Peptidoglycan-associated lipoprotein ACZ76_15315 ENOG4105UFD tol-pal system protein YbgF ACZ76_15345 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ACZ76_15350 ENOG4105PGM cation diffusion facilitator family transporter ACZ76_15355 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACZ76_15360 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACZ76_15365 ENOG4105VIF phosphate starvation-inducible protein ACZ76_15370 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ACZ76_15375 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ACZ76_15380 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ACZ76_15385 ENOG4105CMR udp-glucose 4-epimerase ACZ76_15395 ENOG4105DKW ABC transporter ACZ76_15400 ENOG4105F4R Transcriptional regulator mode ACZ76_15405 ENOG410680R Protein of unknown function (DUF2592) ACZ76_15410 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ACZ76_15415 ENOG4105E0C molybdate abc transporter ACZ76_15425 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC ACZ76_15435 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia ACZ76_15440 ENOG4107P2S Transcriptional regulator ACZ76_15445 ENOG4105C6K Malic enzyme ACZ76_15455 ENOG4105PQ6 UPF0208 membrane protein ACZ76_15460 ENOG4105XWI UPF0304 protein ACZ76_15465 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 ACZ76_15475 ENOG4107QWE )-transporter ACZ76_15480 ENOG4105DK2 UPF0207 protein ACZ76_15485 ENOG4105CHM Aminotransferase ACZ76_15490 ENOG4107NQ8 LysR family Transcriptional regulator ACZ76_15495 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain ACZ76_15500 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACZ76_15505 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACZ76_15510 ENOG4105GKE subunit e ACZ76_15515 ENOG4107QIZ NADH dehydrogenase ACZ76_15520 ENOG4108IEH NADH dehydrogenase subunit g ACZ76_15525 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) ACZ76_15530 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACZ76_15535 ENOG4107UFS subunit j ACZ76_15540 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACZ76_15545 ENOG4105D65 subunit l ACZ76_15550 ENOG4105C8S subunit m ACZ76_15555 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ACZ76_15575 ENOG4108UQ5 membrane protein YcdZ ACZ76_15585 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ACZ76_15590 ENOG4105CHR reductase ACZ76_15595 ENOG4105K2J Transcriptional regulator ACZ76_15600 ENOG4105C5I Dehydrogenase ACZ76_15610 ENOG41090KN UPF0303 protein ACZ76_15615 ENOG4105C01 Dihydroxy-acid dehydratase ACZ76_15620 ENOG4105TNS Conserved Protein ACZ76_15630 ENOG4105E4F Isochorismate synthase ACZ76_15635 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ACZ76_15645 ENOG4108IPT Naphthoate synthase ACZ76_15650 ENOG4105DNI Converts SHCHC to OSB (By similarity) ACZ76_15655 ENOG4105CEY Amp-dependent synthetase and ligase ACZ76_15665 ENOG4105CH6 catalase ACZ76_15670 ENOG4108UII YfaZ family ACZ76_15675 ENOG4105E0U tyrosine-specific transport protein ACZ76_15710 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) ACZ76_15715 ENOG4105XPH Ferredoxin ACZ76_15720 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACZ76_15725 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACZ76_15730 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ACZ76_15735 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACZ76_15740 ENOG4105BZU Histidine kinase ACZ76_15745 ENOG41068CG regulatoR ACZ76_15750 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC ACZ76_15755 ENOG4106UW1 Major Facilitator superfamily ACZ76_15765 ENOG4105C42 Type I secretion membrane fusion protein (HlyD ACZ76_15770 ENOG4105FCK Membrane ACZ76_15785 ENOG4107R6D beta-lactam binding protein AmpH ACZ76_15790 ENOG4105CT4 transporter ACZ76_15800 ENOG4105C8Q Methyl-accepting chemotaxis ACZ76_15805 ENOG4108NC2 Outer membrane protease ACZ76_15810 ENOG4105Y50 Virulence Protein ACZ76_15820 ENOG4105HRS Antitermination protein ACZ76_15840 ENOG4105TKZ Tail Sheath ACZ76_15880 ENOG4108T86 baseplate J family protein ACZ76_15900 ENOG4108Q3X Transcriptional regulator ACZ76_15905 ENOG4105C5Y PTS System ACZ76_15910 ENOG4105CS2 ec 3.2.1.21 ACZ76_15925 ENOG4105HVQ Regulatory factor of maltose metabolism ACZ76_15955 ENOG4105KT5 UmuD protein ACZ76_15970 ENOG4105E68 Sulfatase ACZ76_15975 ENOG4105PAN UPF0352 protein ACZ76_15980 ENOG4106V8H Nucleoid-associated protein ACZ76_15990 ENOG4105CFI type iii restriction protein res subunit ACZ76_15995 ENOG4105I08 Pseudouridine synthase ACZ76_16000 ENOG4105C2C drug resistance transporter, Bcr CflA ACZ76_16005 ENOG4105HG6 ACZ76_16010 ENOG4108JQ5 ABC transporter ACZ76_16015 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ACZ76_16020 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ACZ76_16025 ENOG4105E43 Extracellular solute-binding protein, family 5 ACZ76_16030 ENOG4105CXC rtn protein ACZ76_16035 ENOG4107TT5 NLP P60 protein ACZ76_16040 ENOG41076MN Phosphoesterase, PA-phosphatase related ACZ76_16045 ENOG4105CKI cobalamin synthesis protein ACZ76_16055 ENOG4107YCY Transcriptional regulator ACZ76_16060 ENOG4105DEI Mannitol dehydrogenase ACZ76_16065 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) ACZ76_16070 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ACZ76_16080 ENOG4105KRS Proteinase inhibitor ACZ76_16085 ENOG4107QY8 reductase ACZ76_16090 ENOG4105CUW cytochrome C-TYPE protein ACZ76_16100 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ACZ76_16105 ENOG4105DE4 1-phosphofructokinase ACZ76_16110 ENOG4105DM4 PTS System ACZ76_16115 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ACZ76_16120 ENOG4105HMI Membrane ACZ76_16135 ENOG4105DUM transcriptional regulator, lysR family ACZ76_16140 ENOG4108IQI permease ACZ76_16145 ENOG4105EHG Permease protein ACZ76_16155 ENOG4105D05 Receptor ACZ76_16160 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) ACZ76_16180 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) ACZ76_16185 ENOG4108TGY Glutathione S-transferase ACZ76_16200 ENOG4105D01 (LipO)protein ACZ76_16210 ENOG4108UMI ABC transporter, permease ACZ76_16220 ENOG4105C28 cystathionine ACZ76_16230 ENOG4105DZ1 carboxypeptidase ACZ76_16235 ENOG4105EJQ L-serine dehydratase ACZ76_16240 ENOG4105C44 Serine transporter ACZ76_16245 ENOG4107FB0 transcriptional regulator DeoR family ACZ76_16250 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ACZ76_16255 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ACZ76_16265 ENOG4105D0C transport protein ACZ76_16270 ENOG41090BQ Glutaredoxin ACZ76_16275 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress ACZ76_16280 ENOG4108RMJ sensory transduction regulator ACZ76_16285 ENOG4107RUE extracellular solute-binding protein family 1 ACZ76_16290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACZ76_16295 ENOG4105F38 ABC transporter, permease ACZ76_16300 ENOG4105D38 putrescine abc transporter ACZ76_16305 ENOG4105RBQ inner membrane protein ybjO ACZ76_16315 ENOG4106TNF Periplasmic binding protein ACZ76_16320 ENOG4105DMR ABC, transporter ACZ76_16325 ENOG4105GBT ABC transporter ACZ76_16330 ENOG4106PMH Extracellular solute-binding protein family 3 ACZ76_16335 ENOG4105E5Z arginine transporter ATP-binding subunit ACZ76_16340 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) ACZ76_16345 ENOG41064MM (LipO)protein ACZ76_16350 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ACZ76_16355 ENOG4105CGD Nad-dependent epimerase dehydratase ACZ76_16360 ENOG4105C5W Aldolase ACZ76_16370 ENOG4105C7K acetolactate synthase ACZ76_16375 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ACZ76_16380 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) ACZ76_16385 ENOG4105DWU Membrane ACZ76_16390 ENOG4105CPB ATP-dependent endonuclease of the OLD family ACZ76_16395 ENOG4108MJ5 VirK protein ACZ76_16400 ENOG4105DJY efflux transporter, rnd family, mfp subunit ACZ76_16410 ENOG4105VEQ Cold shock protein ACZ76_16415 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ACZ76_16420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACZ76_16425 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ACZ76_16430 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ACZ76_16435 ENOG4108JJ8 (ABC) transporter ACZ76_16440 ENOG4108JJ9 ABC, transporter ACZ76_16445 ENOG4105C3M thioredoxin reductase ACZ76_16450 ENOG4105EW9 transcriptional regulator AsnC family ACZ76_16455 ENOG4105CNU cell division protein FtsK ACZ76_16460 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) ACZ76_16465 ENOG4105D1H recombination factor protein RarA ACZ76_16470 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ACZ76_16475 ENOG4108ISG Major Facilitator ACZ76_16480 ENOG4105F1A Pyruvate formate-lyase ACZ76_16485 ENOG4105C6N Formate acetyltransferase ACZ76_16490 ENOG4105TMB Formate nitrite transporter ACZ76_16495 ENOG4105DDY UPF0142 protein ycaO ACZ76_16500 ENOG4105HDK L-asparaginase ACZ76_16505 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ACZ76_16510 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ACZ76_16515 ENOG4105CAT Cytidine monophosphate kinase ACZ76_16520 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ACZ76_16525 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ACZ76_16530 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ACZ76_16545 ENOG4105E32 cytoplasmic protein ACZ76_16550 ENOG4105VEQ Cold shock protein ACZ76_16555 ENOG4105W49 UPF0434 protein ACZ76_16565 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups ACZ76_16570 ENOG4107S90 membrAne ACZ76_16575 ENOG4106371 Methyltransferase ACZ76_16580 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) ACZ76_16585 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ACZ76_16595 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ACZ76_16600 ENOG4105EAQ (twin-arginine translocation) pathway signal ACZ76_16605 ENOG4105C5X domain protein ACZ76_16610 ENOG4105BZU Histidine kinase ACZ76_16615 ENOG4105CGF Aromatic amino acid aminotransferase ACZ76_16625 ENOG4105C5S asparaginyl-tRNA synthetase ACZ76_16630 ENOG4107RH7 Nicotinate phosphoribosyltransferase ACZ76_16635 ENOG4105CD8 aminopeptidase N ACZ76_16640 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) ACZ76_16645 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ACZ76_16650 ENOG4105QVC MOSC domain-containing protein ACZ76_16655 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ACZ76_16660 ENOG4105C5H ABC transporter ACZ76_16665 ENOG4105F1S paraquat-inducible protein a ACZ76_16670 ENOG4105DY2 Paraquat-inducible protein b ACZ76_16675 ENOG4108Q2G (LipO)protein ACZ76_16680 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACZ76_16690 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) ACZ76_16695 ENOG4105DAN ATP-dependent protease ACZ76_16700 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) ACZ76_16705 ENOG4105UYK outer membrane protein a ACZ76_16710 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) ACZ76_16715 ENOG4108RZ1 DNA transformation protein ACZ76_16720 ENOG4105EM2 membrane ACZ76_16725 ENOG410901E Membrane ACZ76_16730 ENOG41088T4 Helicase IV ACZ76_16735 ENOG4108Z5K methylglyoxal synthase ACZ76_16740 ENOG4108Q67 UPF0319 protein ACZ76_16745 ENOG4105K4P CoA-binding domain protein ACZ76_16750 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) ACZ76_16755 ENOG4105DR4 Methyltransferase ACZ76_16775 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ACZ76_16780 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ACZ76_16795 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ACZ76_16800 ENOG4105DUU IucA IucC family protein ACZ76_16820 ENOG4105Q26 Siderophore-interacting protein ACZ76_16825 ENOG4105EAU Plays a role in nitrite reduction (By similarity) ACZ76_16830 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit ACZ76_16835 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACZ76_16840 ENOG4105DVI reductase, NrfD ACZ76_16845 ENOG4105DA4 cytochrome c-type biogenesis protein ACZ76_16850 ENOG4107QX9 Thiol disulfide interChange protein ACZ76_16860 ENOG4108DMF Cytochrome C biogenesis protein ACZ76_16865 ENOG4105VJY transcriptional regulator ACZ76_16870 ENOG4107YC3 synthase ACZ76_16880 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) ACZ76_16895 ENOG4105DJ9 glucan biosynthesis protein ACZ76_16900 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) ACZ76_16905 ENOG4105NAC (LipO)protein ACZ76_16915 ENOG4105DUX Transporter ACZ76_16920 ENOG4105C6X Major Facilitator ACZ76_16925 ENOG4108VGI doxx family ACZ76_16930 ENOG4105D1S lipid A biosynthesis ACZ76_16935 ENOG4108ZXC Two component transcriptional regulator, luxr family ACZ76_16940 ENOG4106AFQ Histidine kinase ACZ76_16945 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ACZ76_16950 ENOG4106WHD Tetrathionate reductase ACZ76_16955 ENOG4105DB1 molybdopterin oxidoreductase ACZ76_16970 ENOG4105DSF transport protein ACZ76_16985 ENOG4105PVA Biofilm formation regulatory protein BssS ACZ76_16995 ENOG4105EKE dihydroorotase ACZ76_17000 ENOG41067V3 Antibiotic biosynthesis monooxygenase ACZ76_17005 ENOG4107QQB Ribonuclease E ACZ76_17005 ENOG4107QQB Ribonuclease E ACZ76_17010 ENOG4105EI2 Pseudouridine synthase ACZ76_17020 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ACZ76_17025 ENOG4105VGS 50s ribosomal protein l32 ACZ76_17030 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ACZ76_17040 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ACZ76_17045 ENOG4105CHR reductase ACZ76_17055 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACZ76_17060 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ACZ76_17065 ENOG4105HHA aminodeoxychorismate lyase ACZ76_17070 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ACZ76_17075 ENOG4107QRG dna polymerase iii ACZ76_17080 ENOG4105F8V Hydrolase, tatD family ACZ76_17085 ENOG4105CI1 PTS System ACZ76_17090 ENOG4105ZTC transcriptional activator, Ogr delta ACZ76_17155 ENOG4105MZU cell filamentation protein ACZ76_17220 ENOG4105ED4 portal protein ACZ76_17245 ENOG4105DFE Dna adenine methylase ACZ76_17285 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACZ76_17305 ENOG4108JJA ABC, transporter ACZ76_17315 ENOG4105C4X radical SAM domain protein ACZ76_17320 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ACZ76_17325 ENOG4105F9E Shikimate 5-dehydrogenase ACZ76_17330 ENOG4105K59 histidine triad (HIT) protein ACZ76_17335 ENOG41090DQ Lipoprotein ACZ76_17340 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) ACZ76_17345 ENOG4108RUM thiamine kinase ACZ76_17355 ENOG4105D0Y UPF0227 protein ACZ76_17360 ENOG4105CEP NADH dehydrogenase ACZ76_17365 ENOG4107MBR 17 kDa surface antigen ACZ76_17370 ENOG4108JA2 transcriptioN-repair coupling factor ACZ76_17375 ENOG4105D60 lipoprotein releasing system transmembrane protein ACZ76_17385 ENOG4105D60 lipoprotein releasing system transmembrane protein ACZ76_17390 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) ACZ76_17395 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ACZ76_17405 ENOG4105EZE Cupin 4 family protein ACZ76_17415 ENOG4105XJC Two component transcriptional regulator (Winged helix family ACZ76_17425 ENOG4107QTF adenylosuccinate lyase ACZ76_17430 ENOG41075W9 High frequency lysogenization protein HflD homolog ACZ76_17435 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ACZ76_17445 ENOG4108R99 pseudouridine synthase ACZ76_17450 ENOG4108HMX isocitrate dehydrogenase (NADP) ACZ76_17460 ENOG4108HCJ Hydrolase ACZ76_17465 ENOG4106UW1 Major Facilitator superfamily ACZ76_17475 ENOG4105C85 amino acid ACZ76_17490 ENOG4108MRH transcriptional regulatory protein ACZ76_17495 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ACZ76_17500 ENOG4105CSV Glutaminase ACZ76_17515 ENOG4105DDV Transcriptional regulator (LacI family ACZ76_17520 ENOG4105VZJ PTS System ACZ76_17525 ENOG4105CK1 PTS System ACZ76_17530 ENOG4105CS2 ec 3.2.1.21 ACZ76_17535 ENOG4105VCP PTS System ACZ76_17545 ENOG4107SJW iron permease, FTR1 ACZ76_17560 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACZ76_17570 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACZ76_17590 ENOG4105EXG Transcriptional regulator ACZ76_17600 ENOG4105H1N peptidase, M24 ACZ76_17605 ENOG4108TUY outer membrane protein PgaA ACZ76_17610 ENOG4107BJW polysaccharide deacetylase ACZ76_17615 ENOG4105CND Glycosyl transferase, family 2 ACZ76_17620 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD ACZ76_17630 ENOG4105D5M phosphate starvation-inducible protein ACZ76_17635 ENOG4105EWV Sodium calcium exchanger membrane region ACZ76_17645 ENOG4107R11 Transcriptional regulator ACZ76_17650 ENOG4105BZU Histidine kinase ACZ76_17655 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ACZ76_17660 ENOG4105C4M (Ubiquinol oxidase) subunit I ACZ76_17665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACZ76_17670 ENOG4105C8Y Acetylornithine aminotransferase ACZ76_17675 ENOG4105F4X arginine ACZ76_17685 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) ACZ76_17690 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) ACZ76_17705 ENOG4105CI2 imidazolone-5-propionate hydrolase ACZ76_17710 ENOG4105CZE histidine utilization repressor ACZ76_17720 ENOG41090B9 response to stress ACZ76_17730 ENOG4105C2J ABC transporter ACZ76_17735 ENOG4108HWV )-transporter ACZ76_17740 ENOG4108MEK Metal-binding protein YodA ACZ76_17750 ENOG4108K5P (LipO)protein ACZ76_17755 ENOG4105SUA Ydil protein ACZ76_17760 ENOG4105EMV Major Facilitator ACZ76_17765 ENOG4105DND Transcriptional regulator ACZ76_17770 ENOG4105EMV Major Facilitator ACZ76_17785 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) ACZ76_17790 ENOG4105C1G acyl-Coa dehydrogenase ACZ76_17795 ENOG4105W4W Transcriptional regulator ACZ76_17800 ENOG4105CV7 Electron transfer flavoprotein ACZ76_17805 ENOG4105C10 Electron transfer flavoprotein ACZ76_17810 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ACZ76_17815 ENOG41090P5 ferredoxin-like protein ACZ76_17820 ENOG4105CEY Amp-dependent synthetase and ligase ACZ76_17830 ENOG4105D17 glycoside hydrolase, family 3 domain protein ACZ76_17855 ENOG4105WH1 Two component transcriptional regulator luxr family ACZ76_17860 ENOG4105C3G gtp-binding protein ACZ76_17870 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ACZ76_17875 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria