locus-tag	class	description
ACZ76_00015	COG3077	Addiction module antitoxin, RelB DinJ family
ACZ76_00020	COG2026	Addiction module toxin, RelE StbE family
ACZ76_00060	COG3772	lysozyme
ACZ76_00140	COG1396	sequence-specific DNA binding
ACZ76_00175	COG0582	viral genome integration into host DNA
ACZ76_00185	COG1276	copper resistance
ACZ76_00190	COG2372	response to copper ion
ACZ76_00195	COG1528	Iron-storage protein
ACZ76_00210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACZ76_00215	COG1770	oligopeptidase
ACZ76_00230	COG3141	response to X-ray
ACZ76_00235	COG0513	Belongs to the DEAD box helicase family
ACZ76_00240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACZ76_00245	COG3140	Belongs to the UPF0181 family
ACZ76_00255	COG0494	nUDIX hydrolase
ACZ76_00260	COG1760	l-serine dehydratase
ACZ76_00265	COG1253	flavin adenine dinucleotide binding
ACZ76_00270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_00270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_00275	COG3715	PTS system
ACZ76_00280	COG3716	PTS system mannose fructose sorbose family IID component
ACZ76_00285	COG4811	Protein of unknown function (DUF986)
ACZ76_00290	COG1971	Probably functions as a manganese efflux pump
ACZ76_00300	COG5001	Diguanylate cyclase
ACZ76_00300	COG3447	MASE1 domain protein
ACZ76_00300	COG5002	protein histidine kinase activity
ACZ76_00310	COG2226	methyltransferase
ACZ76_00315	COG0768	penicillin binding
ACZ76_00325	COG1278	Cold shock
ACZ76_00335	COG1113	amino acid transport
ACZ76_00370	COG2207	Transcriptional regulator
ACZ76_00390	COG1132	(ABC) transporter
ACZ76_00400	COG4251	negative regulation of phosphorylation
ACZ76_00400	COG5001	Diguanylate cyclase
ACZ76_00400	COG3706	GGDEF domain
ACZ76_00400	COG2203	Gaf domain
ACZ76_00415	COG3755	Protein conserved in bacteria
ACZ76_00425	COG0697	spore germination
ACZ76_00430	COG1733	regulation of RNA biosynthetic process
ACZ76_00435	COG0702	epimerase
ACZ76_00440	COG2873	o-acetylhomoserine
ACZ76_00445	COG0840	transmembrane signaling receptor activity
ACZ76_00465	COG4974	Belongs to the 'phage' integrase family
ACZ76_00545	COG0210	DNA helicase
ACZ76_00560	COG4695	Portal protein
ACZ76_00650	COG5301	cellulose 1,4-beta-cellobiosidase activity
ACZ76_00715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACZ76_00720	COG0322	excinuclease ABC activity
ACZ76_00725	COG2197	response regulator
ACZ76_00735	COG3136	membrane protein required for alginate biosynthesis
ACZ76_00745	COG0840	transmembrane signaling receptor activity
ACZ76_00750	COG0366	Alpha amylase catalytic
ACZ76_00765	COG2226	methyltransferase
ACZ76_00775	COG1113	amino acid transport
ACZ76_00780	COG1309	transcriptional regulator
ACZ76_00785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACZ76_00790	COG1335	isochorismatase
ACZ76_00795	COG0251	oxidation-reduction process
ACZ76_00800	COG2267	carboxylic ester hydrolase activity
ACZ76_00805	COG0778	Nitroreductase
ACZ76_00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACZ76_00815	COG2233	PERMEase
ACZ76_00835	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ACZ76_00865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACZ76_00870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACZ76_00870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACZ76_00870	COG0506	proline dehydrogenase activity
ACZ76_00900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ACZ76_00910	COG1191	sigma factor activity
ACZ76_00945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACZ76_00950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ACZ76_00955	COG1677	Flagellar hook-basal body complex protein FliE
ACZ76_00965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACZ76_00970	COG1317	bacterial-type flagellum organization
ACZ76_00980	COG2882	bacterial-type flagellum organization
ACZ76_00985	COG3144	bacterial-type flagellum assembly
ACZ76_01010	COG1338	Plays a role in the flagellum-specific transport system
ACZ76_01025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACZ76_01030	COG1256	bacterial-type flagellum assembly
ACZ76_01050	COG4786	Flagellar basal body rod
ACZ76_01060	COG1749	Flagellar hook protein flgE
ACZ76_01065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ACZ76_01070	COG1558	bacterial-type flagellum-dependent cell motility
ACZ76_01075	COG1815	bacterial-type flagellum-dependent cell motility
ACZ76_01085	COG2747	anti-sigma28 factor FlgM
ACZ76_01090	COG3418	PFAM FlgN family protein
ACZ76_01100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACZ76_01105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACZ76_01110	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ACZ76_01115	COG0745	RESPONSE REGULATOR receiver
ACZ76_01125	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACZ76_01130	COG0840	transmembrane signaling receptor activity
ACZ76_01135	COG0840	transmembrane signaling receptor activity
ACZ76_01140	COG0835	chemotaxis
ACZ76_01145	COG0643	Histidine kinase
ACZ76_01145	COG2198	Histidine kinase
ACZ76_01170	COG0589	response to stress
ACZ76_01175	COG2130	NADP-dependent
ACZ76_01185	COG1285	pathogenesis
ACZ76_01190	COG0840	transmembrane signaling receptor activity
ACZ76_01200	COG1278	Cold shock
ACZ76_01210	COG1609	Transcriptional regulator
ACZ76_01215	COG3250	beta-galactosidase activity
ACZ76_01220	COG0604	alcohol dehydrogenase
ACZ76_01220	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_01220	COG3321	synthase
ACZ76_01250	COG3121	Chaperone
ACZ76_01265	COG3121	Chaperone
ACZ76_01275	COG3121	Chaperone
ACZ76_01295	COG3228	Belongs to the MtfA family
ACZ76_01305	COG3423	Transcriptional regulator
ACZ76_01320	COG0471	metal ion transport
ACZ76_01335	COG3051	citrate lyase alpha subunit
ACZ76_01340	COG2301	Belongs to the HpcH HpaI aldolase family
ACZ76_01345	COG3052	prosthetic group binding
ACZ76_01350	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ACZ76_01355	COG3290	protein histidine kinase activity
ACZ76_01360	COG4565	transcriptional regulatory protein
ACZ76_01375	COG2271	Major facilitator Superfamily
ACZ76_01380	COG1840	ABC-type Fe3 transport system, periplasmic component
ACZ76_01390	COG3842	ATPase activity
ACZ76_01405	COG2205	protein histidine kinase activity
ACZ76_01405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_01415	COG3121	Chaperone
ACZ76_01420	COG3188	usher protein
ACZ76_01430	COG3121	Chaperone
ACZ76_01435	COG1187	pseudouridine synthase activity
ACZ76_01465	COG3122	Protein conserved in bacteria
ACZ76_01485	COG4221	oxidoreductase activity
ACZ76_01490	COG0835	chemotaxis
ACZ76_01490	COG0784	Response regulator, receiver
ACZ76_01495	COG0583	DNA-binding transcription factor activity
ACZ76_01510	COG1349	DNA-binding transcription factor activity
ACZ76_01515	COG0352	thiamine-phosphate diphosphorylase activity
ACZ76_01525	COG0534	Mate efflux family protein
ACZ76_01530	COG0137	argininosuccinate synthase activity
ACZ76_01540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ACZ76_01560	COG1492	cobalamin metabolic process
ACZ76_01610	COG2875	Belongs to the precorrin methyltransferase family
ACZ76_01620	COG2241	protein methyltransferase activity
ACZ76_01625	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
ACZ76_01635	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ACZ76_01655	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ACZ76_01690	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ACZ76_01720	COG1012	belongs to the aldehyde dehydrogenase family
ACZ76_01730	COG4656	Part of a membrane complex involved in electron transport
ACZ76_01740	COG4810	utilization protein
ACZ76_01750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACZ76_01755	COG1648	precorrin-2 dehydrogenase activity
ACZ76_01755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACZ76_01760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACZ76_01770	COG1879	ABC-type sugar transport system periplasmic component
ACZ76_01775	COG1129	ABC transporter
ACZ76_01780	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_01790	COG2926	Belongs to the UPF0265 family
ACZ76_01795	COG1289	transmembrane transporter activity
ACZ76_01805	COG2925	Exonuclease
ACZ76_01810	COG0531	amino acid
ACZ76_01815	COG0371	Dehydrogenase
ACZ76_01820	COG1129	ABC transporter
ACZ76_01825	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_01830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACZ76_01835	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACZ76_01840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACZ76_01845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACZ76_01850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACZ76_01850	COG0131	Imidazoleglycerol-phosphate dehydratase
ACZ76_01855	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACZ76_01860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACZ76_01865	COG0107	imidazoleglycerol-phosphate synthase activity
ACZ76_01870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACZ76_01870	COG0140	phosphoribosyl-ATP diphosphatase activity
ACZ76_01875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ACZ76_01880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACZ76_01885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACZ76_01905	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ACZ76_01935	COG1253	flavin adenine dinucleotide binding
ACZ76_01940	COG3069	C4-dicarboxylate transmembrane transporter activity
ACZ76_01945	COG2982	Protein involved in outer membrane biogenesis
ACZ76_01955	COG0572	uridine kinase
ACZ76_01960	COG0489	protein tyrosine kinase activity
ACZ76_01965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACZ76_01965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACZ76_01980	COG2814	Major facilitator Superfamily
ACZ76_01985	COG1380	Effector of murein hydrolase LrgA
ACZ76_01990	COG1346	cytolysis
ACZ76_02000	COG0281	malic enzyme
ACZ76_02005	COG2949	membrane
ACZ76_02010	COG0298	carbon dioxide binding
ACZ76_02015	COG0375	protein maturation
ACZ76_02020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACZ76_02025	COG0651	ATP synthesis coupled electron transport
ACZ76_02030	COG0650	Formate hydrogenlyase subunit 4
ACZ76_02035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACZ76_02040	COG4237	Hydrogenase 4 membrane
ACZ76_02045	COG0651	ATP synthesis coupled electron transport
ACZ76_02050	COG3261	NADH dehydrogenase
ACZ76_02050	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ACZ76_02055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACZ76_02060	COG3260	NADH ubiquinone oxidoreductase 20
ACZ76_02070	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACZ76_02075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACZ76_02080	COG3383	formate dehydrogenase (NAD+) activity
ACZ76_02085	COG3604	Transcriptional regulator
ACZ76_02090	COG2116	formate transmembrane transporter activity
ACZ76_02115	COG2311	Membrane
ACZ76_02120	COG0302	gtp cyclohydrolase
ACZ76_02125	COG0477	Major facilitator Superfamily
ACZ76_02130	COG0583	DNA-binding transcription factor activity
ACZ76_02165	COG0477	Major facilitator Superfamily
ACZ76_02175	COG0303	'Molybdopterin
ACZ76_02180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACZ76_02185	COG0488	(ABC) transporter
ACZ76_02205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ACZ76_02220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ACZ76_02235	COG4106	trans-aconitate 2-methyltransferase activity
ACZ76_02240	COG0783	Belongs to the Dps family
ACZ76_02245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACZ76_02250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_02255	COG0765	amino acid transport
ACZ76_02260	COG1126	abc transporter atp-binding protein
ACZ76_02270	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ACZ76_02275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACZ76_02290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACZ76_02295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACZ76_02315	COG0697	spore germination
ACZ76_02325	COG1982	Orn Lys Arg decarboxylase major
ACZ76_02330	COG0531	amino acid
ACZ76_02340	COG1174	glycine betaine transport
ACZ76_02345	COG1125	glycine betaine transport
ACZ76_02350	COG1174	glycine betaine transport
ACZ76_02355	COG1732	Glycine betaine
ACZ76_02370	COG2897	thiosulfate sulfurtransferase activity
ACZ76_02380	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ACZ76_02400	COG4807	Protein conserved in bacteria
ACZ76_02415	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ACZ76_02425	COG2261	transglycosylase associated protein
ACZ76_02435	COG1403	HNH endonuclease
ACZ76_02445	COG0277	FAD linked oxidase domain protein
ACZ76_02450	COG1686	Belongs to the peptidase S11 family
ACZ76_02465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACZ76_02470	COG0513	Belongs to the DEAD box helicase family
ACZ76_02475	COG1309	transcriptional regulator
ACZ76_02480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_02485	COG1131	(ABC) transporter
ACZ76_02490	COG0842	Transport permease protein
ACZ76_02495	COG0842	Transport permease protein
ACZ76_02500	COG0670	Belongs to the BI1 family
ACZ76_02505	COG0314	molybdopterin synthase activity
ACZ76_02510	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACZ76_02515	COG0315	cyclic pyranopterin monophosphate synthase activity
ACZ76_02520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACZ76_02525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACZ76_02530	COG4628	conserved protein (DUF2132)
ACZ76_02535	COG0556	nucleotide-excision repair
ACZ76_02545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACZ76_02550	COG2226	methyltransferase
ACZ76_02560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACZ76_02575	COG0561	phosphatase activity
ACZ76_02580	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACZ76_02585	COG0622	Phosphoesterase
ACZ76_02595	COG1090	epimerase
ACZ76_02605	COG4160	amino acid transport
ACZ76_02610	COG4215	(ABC) transporter
ACZ76_02615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_02620	COG0163	prenyltransferase activity
ACZ76_02625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACZ76_02630	COG1286	toxin biosynthetic process
ACZ76_02635	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ACZ76_02640	COG0285	dihydrofolate synthase activity
ACZ76_02650	COG0586	Pfam SNARE associated Golgi protein
ACZ76_02660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACZ76_02680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACZ76_02690	COG4232	protein-disulfide reductase activity
ACZ76_02705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACZ76_02715	COG1794	racemase activity, acting on amino acids and derivatives
ACZ76_02720	COG3706	GGDEF domain
ACZ76_02720	COG0745	RESPONSE REGULATOR receiver
ACZ76_02725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACZ76_02740	COG3101	peptidyl-lysine hydroxylation
ACZ76_02745	COG0730	response to heat
ACZ76_02750	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ACZ76_02755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACZ76_02760	COG2890	protein-(glutamine-N5) methyltransferase activity
ACZ76_02765	COG2840	Smr protein MutS2
ACZ76_02775	COG2062	phosphohistidine phosphatase, SixA
ACZ76_02780	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACZ76_02780	COG1024	Enoyl-CoA hydratase
ACZ76_02785	COG0183	Belongs to the thiolase family
ACZ76_02790	COG3691	Protein conserved in bacteria
ACZ76_02815	COG3088	subunit of a heme lyase
ACZ76_02815	COG4235	cytochrome complex assembly
ACZ76_02820	COG4235	cytochrome complex assembly
ACZ76_02820	COG3088	subunit of a heme lyase
ACZ76_02825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACZ76_02830	COG1138	Cytochrome C-type biogenesis protein
ACZ76_02835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ACZ76_02840	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACZ76_02845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACZ76_02850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACZ76_02865	COG2824	Alkylphosphonate utilization operon protein PhnA
ACZ76_02870	COG1695	Transcriptional regulator
ACZ76_02880	COG2723	6-phospho-beta-galactosidase activity
ACZ76_02885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_02885	COG1263	PTS System
ACZ76_02890	COG1609	Transcriptional regulator
ACZ76_02895	COG2353	YceI-like domain
ACZ76_02900	COG3038	cytochrome b561
ACZ76_02915	COG1127	ABC transporter
ACZ76_02920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACZ76_02940	COG0531	amino acid
ACZ76_02945	COG2951	lytic endotransglycosylase activity
ACZ76_02970	COG0243	molybdopterin cofactor binding
ACZ76_02975	COG0437	4 iron, 4 sulfur cluster binding
ACZ76_02980	COG3302	dmso reductase anchor subunit
ACZ76_02985	COG3381	protein complex oligomerization
ACZ76_03005	COG1598	PFAM Uncharacterised protein family UPF0150
ACZ76_03010	COG3038	cytochrome b561
ACZ76_03015	COG0436	Aminotransferase
ACZ76_03030	COG3275	phosphorelay sensor kinase activity
ACZ76_03035	COG3279	Response regulator of the LytR AlgR family
ACZ76_03040	COG2223	nitrite transmembrane transporter activity
ACZ76_03045	COG0837	glucose binding
ACZ76_03060	COG3961	Belongs to the TPP enzyme family
ACZ76_03065	COG0667	Aldo Keto reductase
ACZ76_03075	COG1914	H( )-stimulated, divalent metal cation uptake system
ACZ76_03080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACZ76_03105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACZ76_03135	COG3530	Putative quorum-sensing-regulated virulence factor
ACZ76_03140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACZ76_03150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ACZ76_03155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACZ76_03160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_03165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACZ76_03170	COG2190	(PTS) system
ACZ76_03175	COG2205	protein histidine kinase activity
ACZ76_03180	COG0745	RESPONSE REGULATOR receiver
ACZ76_03185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_03205	COG4208	sulfate ABC transporter
ACZ76_03210	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACZ76_03215	COG4150	thiosulfate binding
ACZ76_03225	COG1737	Transcriptional regulator
ACZ76_03230	COG2731	YhcH YjgK YiaL family protein
ACZ76_03245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACZ76_03250	COG2837	iron assimilation
ACZ76_03265	COG3111	PFAM Bacterial OB fold (BOF) protein
ACZ76_03270	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_03275	COG2897	thiosulfate sulfurtransferase activity
ACZ76_03295	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_03300	COG1129	ABC transporter
ACZ76_03310	COG0456	acetyltransferase
ACZ76_03315	COG0408	coproporphyrinogen oxidase activity
ACZ76_03320	COG1671	Belongs to the UPF0178 family
ACZ76_03330	COG0494	nUDIX hydrolase
ACZ76_03335	COG3005	denitrification pathway
ACZ76_03340	COG3043	anaerobic respiration
ACZ76_03345	COG0243	molybdopterin cofactor binding
ACZ76_03350	COG3062	negative regulation of establishment of protein localization
ACZ76_03355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACZ76_03355	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACZ76_03360	COG2197	response regulator
ACZ76_03370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACZ76_03380	COG3842	ATPase activity
ACZ76_03385	COG1175	transmembrane transport
ACZ76_03400	COG1393	Belongs to the ArsC family
ACZ76_03405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACZ76_03410	COG1876	peptidase activity
ACZ76_03420	COG0400	carboxylic ester hydrolase activity
ACZ76_03425	COG1444	tRNA N-acetyltransferase activity
ACZ76_03430	COG2707	UPF0756 membrane protein
ACZ76_03435	COG2321	neutral zinc metallopeptidase
ACZ76_03440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACZ76_03445	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ACZ76_03450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACZ76_03455	COG2716	regulation of RNA biosynthetic process
ACZ76_03460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACZ76_03465	COG0628	permease
ACZ76_03470	COG4783	chaperone-mediated protein folding
ACZ76_03475	COG1393	Belongs to the ArsC family
ACZ76_03480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACZ76_03485	COG2233	PERMEase
ACZ76_03495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACZ76_03500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACZ76_03505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACZ76_03525	COG0581	inorganic phosphate transmembrane transporter activity
ACZ76_03530	COG0573	inorganic phosphate transmembrane transporter activity
ACZ76_03535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACZ76_03540	COG0248	Ppx GppA phosphatase
ACZ76_03550	COG2239	Acts as a magnesium transporter
ACZ76_03555	COG5001	Diguanylate cyclase
ACZ76_03555	COG3447	MASE1 domain protein
ACZ76_03555	COG5002	protein histidine kinase activity
ACZ76_03560	COG0443	Heat shock 70 kDa protein
ACZ76_03570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACZ76_03590	COG0477	Major facilitator Superfamily
ACZ76_03595	COG2205	protein histidine kinase activity
ACZ76_03600	COG0745	RESPONSE REGULATOR receiver
ACZ76_03605	COG3422	double-strand break repair
ACZ76_03615	COG1597	lipid kinase activity
ACZ76_03620	COG3730	PTS system glucitol sorbitol-specific
ACZ76_03635	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_03640	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_03645	COG1349	DNA-binding transcription factor activity
ACZ76_03665	COG0351	phosphomethylpyrimidine kinase
ACZ76_03690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACZ76_03690	COG0519	Catalyzes the synthesis of GMP from XMP
ACZ76_03695	COG0516	GMP reductase activity
ACZ76_03695	COG0517	IMP dehydrogenase activity
ACZ76_03700	COG1570	exodeoxyribonuclease VII activity
ACZ76_03705	COG1645	bacterial-type flagellum-dependent swarming motility
ACZ76_03715	COG1160	GTP binding
ACZ76_03720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACZ76_03725	COG2976	Protein conserved in bacteria
ACZ76_03765	COG4953	penicillin-binding protein 1C
ACZ76_03770	COG2373	Large extracellular alpha-helical protein
ACZ76_03775	COG3468	outer membrane autotransporter barrel domain protein
ACZ76_03780	COG3468	outer membrane autotransporter barrel domain protein
ACZ76_03795	COG2975	iron-sulfur cluster assembly
ACZ76_03800	COG0633	Ferredoxin
ACZ76_03805	COG0443	Heat shock 70 kDa protein
ACZ76_03820	COG0822	iron-sulfur transferase activity
ACZ76_03830	COG1959	2 iron, 2 sulfur cluster binding
ACZ76_03835	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACZ76_03840	COG0483	inositol monophosphate 1-phosphatase activity
ACZ76_03845	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACZ76_03850	COG3683	transport system, periplasmic component
ACZ76_03855	COG3711	transcriptional antiterminator
ACZ76_03860	COG2814	Major facilitator Superfamily
ACZ76_03870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACZ76_03870	COG1017	nitric oxide dioxygenase activity
ACZ76_03875	COG2188	Transcriptional regulator
ACZ76_03885	COG3457	Alanine racemase
ACZ76_03890	COG0347	Belongs to the P(II) protein family
ACZ76_03895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACZ76_03895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACZ76_03900	COG2204	response regulator
ACZ76_03905	COG3170	Tfp pilus assembly protein FimV
ACZ76_03910	COG2205	protein histidine kinase activity
ACZ76_03925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACZ76_03930	COG0590	tRNA wobble adenosine to inosine editing
ACZ76_03940	COG0560	Phosphoserine phosphatase
ACZ76_03945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_03945	COG1263	PTS System
ACZ76_03955	COG1737	Transcriptional regulator
ACZ76_03960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACZ76_03965	COG2610	gluconate transmembrane transporter activity
ACZ76_03970	COG0736	holo-[acyl-carrier-protein] synthase activity
ACZ76_03975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACZ76_03980	COG1381	Involved in DNA repair and RecF pathway recombination
ACZ76_03985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACZ76_03995	COG0681	Belongs to the peptidase S26 family
ACZ76_04000	COG0481	GTPase activity
ACZ76_04010	COG3086	response to oxidative stress
ACZ76_04020	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ACZ76_04030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACZ76_04035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACZ76_04040	COG0513	Belongs to the DEAD box helicase family
ACZ76_04045	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ACZ76_04050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACZ76_04055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACZ76_04060	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACZ76_04065	COG0497	DNA recombination
ACZ76_04070	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACZ76_04080	COG2867	negative regulation of translational initiation
ACZ76_04085	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACZ76_04090	COG0582	viral genome integration into host DNA
ACZ76_04145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACZ76_04215	COG1917	Cupin 2, conserved barrel domain protein
ACZ76_04215	COG2169	Transcriptional regulator
ACZ76_04220	COG1447	Phosphotransferase system cellobiose-specific component IIA
ACZ76_04225	COG2723	6-phospho-beta-galactosidase activity
ACZ76_04230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ACZ76_04235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ACZ76_04240	COG2133	pyrroloquinoline quinone binding
ACZ76_04250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACZ76_04255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACZ76_04265	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ACZ76_04270	COG4413	Urea transporter
ACZ76_04295	COG0804	urea catabolic process
ACZ76_04300	COG0832	Belongs to the urease beta subunit family
ACZ76_04320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACZ76_04325	COG0601	transmembrane transport
ACZ76_04340	COG1278	Cold shock
ACZ76_04365	COG4575	ribosome binding
ACZ76_04375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACZ76_04380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACZ76_04385	COG1780	Probably involved in ribonucleotide reductase function
ACZ76_04395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACZ76_04400	COG4175	Glycine betaine
ACZ76_04405	COG4176	ABC-type proline glycine betaine transport system permease component
ACZ76_04410	COG2113	Glycine betaine
ACZ76_04420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACZ76_04425	COG0328	RNA-DNA hybrid ribonuclease activity
ACZ76_04430	COG2226	methyltransferase
ACZ76_04435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACZ76_04440	COG1388	LysM domain
ACZ76_04440	COG0741	lytic transglycosylase activity
ACZ76_04445	COG3021	interspecies interaction between organisms
ACZ76_04450	COG0656	L-ascorbic acid biosynthetic process
ACZ76_04485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACZ76_04495	COG2011	ABC-type metal ion transport system permease component
ACZ76_04500	COG1464	Belongs to the NlpA lipoprotein family
ACZ76_04510	COG1720	tRNA m6t6A37 methyltransferase activity
ACZ76_04520	COG3015	lipoprotein NlpE involved in copper resistance
ACZ76_04530	COG4681	YaeQ
ACZ76_04540	COG4568	rho-dependent transcription termination
ACZ76_04555	COG0346	lactoylglutathione lyase activity
ACZ76_04570	COG0825	malonyl-CoA metabolic process
ACZ76_04575	COG0587	DNA-directed DNA polymerase activity
ACZ76_04580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACZ76_04585	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACZ76_04590	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACZ76_04605	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ACZ76_04615	COG0750	zinc metalloprotease
ACZ76_04620	COG0575	Belongs to the CDS family
ACZ76_04625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACZ76_04630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACZ76_04635	COG0233	cytoplasmic translational termination
ACZ76_04640	COG0528	UMP kinase activity
ACZ76_04645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACZ76_04650	COG0052	Belongs to the universal ribosomal protein uS2 family
ACZ76_04655	COG0024	Methionine aminopeptidase
ACZ76_04660	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACZ76_04665	COG2171	N-acyltransferase activity
ACZ76_04685	COG0564	pseudouridine synthase activity
ACZ76_04690	COG3098	single-species biofilm formation
ACZ76_04700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACZ76_04700	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACZ76_04705	COG1611	Belongs to the LOG family
ACZ76_04715	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ACZ76_04720	COG2363	Small membrane protein
ACZ76_04725	COG0583	DNA-binding transcription factor activity
ACZ76_04735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACZ76_04740	COG2166	iron-sulfur cluster assembly
ACZ76_04745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACZ76_04750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACZ76_04770	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACZ76_04775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACZ76_04775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACZ76_04780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACZ76_04785	COG1074	ATP-dependent DNA helicase activity
ACZ76_04790	COG1025	Belongs to the peptidase M16 family
ACZ76_04795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ACZ76_04805	COG4795	General secretion pathway protein
ACZ76_04825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACZ76_04835	COG1051	belongs to the nudix hydrolase family
ACZ76_04840	COG3066	DNA modification
ACZ76_04845	COG0861	Integral membrane protein TerC family
ACZ76_04850	COG0667	Aldo Keto reductase
ACZ76_04860	COG0477	Major facilitator Superfamily
ACZ76_04865	COG0318	PFAM AMP-dependent synthetase and ligase
ACZ76_04865	COG0204	Acyl-transferase
ACZ76_04875	COG1609	Transcriptional regulator
ACZ76_04880	COG0019	diaminopimelate decarboxylase activity
ACZ76_04885	COG0583	DNA-binding transcription factor activity
ACZ76_04890	COG2814	Major facilitator Superfamily
ACZ76_04895	COG0583	DNA-binding transcription factor activity
ACZ76_04920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACZ76_04955	COG1459	type II secretion system
ACZ76_04980	COG1733	regulation of RNA biosynthetic process
ACZ76_04985	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_04995	COG0484	heat shock protein binding
ACZ76_05005	COG2271	Major facilitator Superfamily
ACZ76_05020	COG1522	sequence-specific DNA binding
ACZ76_05025	COG3706	GGDEF domain
ACZ76_05030	COG4319	ketosteroid isomerase
ACZ76_05050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACZ76_05055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACZ76_05060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACZ76_05065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACZ76_05070	COG4974	Belongs to the 'phage' integrase family
ACZ76_05075	COG0716	FMN binding
ACZ76_05080	COG4452	Inner membrane protein CreD
ACZ76_05085	COG2205	protein histidine kinase activity
ACZ76_05090	COG0745	RESPONSE REGULATOR receiver
ACZ76_05100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ACZ76_05105	COG0354	folic acid binding
ACZ76_05110	COG1272	protein, Hemolysin III
ACZ76_05115	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_05120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACZ76_05120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACZ76_05125	COG0509	glycine decarboxylation via glycine cleavage system
ACZ76_05130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACZ76_05135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACZ76_05140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACZ76_05145	COG0006	proline dipeptidase activity
ACZ76_05150	COG3079	Belongs to the UPF0149 family
ACZ76_05155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ACZ76_05160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACZ76_05165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACZ76_05170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACZ76_05175	COG0583	DNA-binding transcription factor activity
ACZ76_05185	COG1279	arginine transmembrane transporter activity
ACZ76_05200	COG0191	fructose-bisphosphate aldolase activity
ACZ76_05205	COG0126	phosphoglycerate kinase activity
ACZ76_05210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACZ76_05220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACZ76_05225	COG0501	Belongs to the peptidase M48B family
ACZ76_05235	COG1166	arginine decarboxylase activity
ACZ76_05245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACZ76_05260	COG0640	Transcriptional regulator
ACZ76_05265	COG3091	SprT-like family
ACZ76_05270	COG2356	endonuclease I
ACZ76_05275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACZ76_05280	COG0189	ligase activity
ACZ76_05285	COG1678	Uncharacterized ACR, COG1678
ACZ76_05290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACZ76_05295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACZ76_05305	COG2805	Type II/IV secretion system protein
ACZ76_05310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACZ76_05315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACZ76_05320	COG0762	integral membrane protein
ACZ76_05325	COG1872	DUF167
ACZ76_05330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACZ76_05335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACZ76_05340	COG2826	transposase and inactivated derivatives, IS30 family
ACZ76_05355	COG2066	Belongs to the glutaminase family
ACZ76_05360	COG3171	Protein conserved in bacteria
ACZ76_05365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACZ76_05370	COG1194	a g-specific adenine glycosylase
ACZ76_05380	COG0741	lytic transglycosylase activity
ACZ76_05385	COG1982	Orn Lys Arg decarboxylase major
ACZ76_05520	COG3047	cAMP biosynthetic process
ACZ76_05520	COG2885	chlorophyll binding
ACZ76_05545	COG0288	reversible hydration of carbon dioxide
ACZ76_05555	COG1289	transmembrane transporter activity
ACZ76_05590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACZ76_05595	COG1737	Transcriptional regulator
ACZ76_05600	COG3069	C4-dicarboxylate transmembrane transporter activity
ACZ76_05605	COG0281	malic enzyme
ACZ76_05615	COG0024	Methionine aminopeptidase
ACZ76_05620	COG4604	ABC transporter, ATP-binding protein
ACZ76_05625	COG4605	iron ion homeostasis
ACZ76_05635	COG4607	ABC-type enterochelin transport system periplasmic component
ACZ76_05640	COG0477	Major facilitator Superfamily
ACZ76_05645	COG1609	Transcriptional regulator
ACZ76_05655	COG1283	sodium-dependent phosphate transmembrane transporter activity
ACZ76_05675	COG4302	ethanolamine ammonia-lyase activity
ACZ76_05680	COG4303	Ethanolamine ammonia lyase large subunit
ACZ76_05695	COG2197	response regulator
ACZ76_05710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_05715	COG5001	Diguanylate cyclase
ACZ76_05720	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACZ76_05725	COG0309	Hydrogenase expression formation protein (HypE)
ACZ76_05730	COG0409	Hydrogenase expression formation protein
ACZ76_05735	COG0298	carbon dioxide binding
ACZ76_05740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACZ76_05745	COG0375	protein maturation
ACZ76_05750	COG1773	rubredoxin
ACZ76_05755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACZ76_05760	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ACZ76_05765	COG5557	Pfam Polysulphide reductase, NrfD
ACZ76_05770	COG0437	4 iron, 4 sulfur cluster binding
ACZ76_05775	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
ACZ76_05790	COG3133	Outer membrane lipoprotein
ACZ76_05800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ACZ76_05805	COG1191	sigma factor activity
ACZ76_05825	COG1516	flagellar protein fliS
ACZ76_05830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACZ76_05835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ACZ76_05840	COG3710	Transcriptional regulator
ACZ76_05870	COG1706	bacterial-type flagellum-dependent cell motility
ACZ76_05880	COG4786	Flagellar basal body rod
ACZ76_05890	COG1749	Flagellar hook protein flgE
ACZ76_05895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ACZ76_05900	COG1558	bacterial-type flagellum-dependent cell motility
ACZ76_05905	COG1815	bacterial-type flagellum-dependent cell motility
ACZ76_05950	COG1677	Flagellar hook-basal body complex protein FliE
ACZ76_05955	COG2204	response regulator
ACZ76_05975	COG1987	bacterial-type flagellum assembly
ACZ76_05980	COG1684	flagellar biosynthetic protein fliR
ACZ76_06000	COG0840	transmembrane signaling receptor activity
ACZ76_06005	COG4592	Periplasmic binding protein
ACZ76_06015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACZ76_06020	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACZ76_06025	COG1120	ATPase activity
ACZ76_06050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_06055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACZ76_06080	COG4964	Belongs to the GSP D family
ACZ76_06130	COG0848	biopolymer transport protein
ACZ76_06135	COG0811	peptide transport
ACZ76_06145	COG0586	Pfam SNARE associated Golgi protein
ACZ76_06150	COG2207	Transcriptional regulator
ACZ76_06155	COG1979	alcohol dehydrogenase
ACZ76_06160	COG0656	L-ascorbic acid biosynthetic process
ACZ76_06170	COG2132	Multicopper oxidase
ACZ76_06175	COG0204	Acyl-transferase
ACZ76_06180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACZ76_06185	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACZ76_06190	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ACZ76_06200	COG0187	DNA topoisomerase II activity
ACZ76_06205	COG3150	esterase
ACZ76_06210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACZ76_06215	COG3151	Protein conserved in bacteria
ACZ76_06220	COG0494	nUDIX hydrolase
ACZ76_06225	COG1538	Outer membrane efflux protein
ACZ76_06230	COG5463	Belongs to the UPF0441 family
ACZ76_06235	COG0754	glutathionylspermidine amidase activity
ACZ76_06240	COG3384	dioxygenase
ACZ76_06245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACZ76_06255	COG0531	amino acid
ACZ76_06260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACZ76_06260	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACZ76_06265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACZ76_06270	COG3025	triphosphatase activity
ACZ76_06275	COG4991	sh3 domain protein
ACZ76_06280	COG0617	tRNA 3'-terminal CCA addition
ACZ76_06285	COG1968	undecaprenyl-diphosphatase activity
ACZ76_06290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACZ76_06295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACZ76_06300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACZ76_06310	COG0358	DNA primase activity
ACZ76_06315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACZ76_06325	COG2814	Major facilitator Superfamily
ACZ76_06330	COG3247	response to pH
ACZ76_06335	COG1902	pentaerythritol trinitrate reductase activity
ACZ76_06335	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACZ76_06345	COG2813	Specifically methylates the guanine in position
ACZ76_06355	COG1451	nucleotide metabolic process
ACZ76_06360	COG0673	inositol 2-dehydrogenase activity
ACZ76_06365	COG0861	Integral membrane protein TerC family
ACZ76_06370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACZ76_06380	COG2721	sulfolactate sulfo-lyase activity
ACZ76_06385	COG0246	Mannitol dehydrogenase
ACZ76_06390	COG1904	glucuronate isomerase
ACZ76_06395	COG2271	Major facilitator Superfamily
ACZ76_06415	COG0586	Pfam SNARE associated Golgi protein
ACZ76_06430	COG4575	ribosome binding
ACZ76_06435	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ACZ76_06445	COG2259	Doxx family
ACZ76_06450	COG0435	Glutathione S-transferase
ACZ76_06455	COG0583	DNA-binding transcription factor activity
ACZ76_06460	COG1741	Belongs to the pirin family
ACZ76_06465	COG0583	DNA-binding transcription factor activity
ACZ76_06475	COG0583	DNA-binding transcription factor activity
ACZ76_06480	COG1064	alcohol dehydrogenase
ACZ76_06510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACZ76_06520	COG0792	nuclease activity
ACZ76_06525	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACZ76_06530	COG2823	Periplasmic or secreted lipoprotein
ACZ76_06535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACZ76_06540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ACZ76_06545	COG5002	protein histidine kinase activity
ACZ76_06545	COG2198	Histidine kinase
ACZ76_06545	COG0784	Response regulator, receiver
ACZ76_06550	COG1242	4 iron, 4 sulfur cluster binding
ACZ76_06555	COG0067	glutamate synthase
ACZ76_06555	COG0069	glutamate synthase activity
ACZ76_06555	COG0070	glutamate synthase
ACZ76_06560	COG0493	'glutamate synthase
ACZ76_06570	COG2969	positive regulation of protein catabolic process
ACZ76_06575	COG0625	glutathione transferase activity
ACZ76_06580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACZ76_06585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACZ76_06590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACZ76_06595	COG3105	Protein conserved in bacteria
ACZ76_06600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACZ76_06605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACZ76_06615	COG5007	Belongs to the BolA IbaG family
ACZ76_06620	COG3113	response to antibiotic
ACZ76_06625	COG2854	intermembrane phospholipid transfer
ACZ76_06630	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACZ76_06635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACZ76_06640	COG1127	ABC transporter
ACZ76_06645	COG0530	calcium, potassium:sodium antiporter activity
ACZ76_06650	COG0517	IMP dehydrogenase activity
ACZ76_06650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACZ76_06655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACZ76_06660	COG3117	lipopolysaccharide transmembrane transporter activity
ACZ76_06665	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ACZ76_06670	COG1137	ATPase activity
ACZ76_06675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACZ76_06685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_06695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_06700	COG0540	Belongs to the ATCase OTCase family
ACZ76_06705	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ACZ76_06715	COG2308	Evidence 4 Homologs of previously reported genes of
ACZ76_06735	COG0366	Alpha amylase catalytic
ACZ76_06740	COG1263	PTS System
ACZ76_06740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_06750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACZ76_06755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_06755	COG3711	transcriptional antiterminator
ACZ76_06760	COG2706	6-phosphogluconolactonase activity
ACZ76_06775	COG3964	amidohydrolase
ACZ76_06805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACZ76_06810	COG3783	Cytochrome b(562)
ACZ76_06815	COG0312	modulator of DNA gyrase
ACZ76_06820	COG3028	Belongs to the UPF0307 family
ACZ76_06825	COG2732	(Barnase) inhibitor
ACZ76_06835	COG1012	belongs to the aldehyde dehydrogenase family
ACZ76_06840	COG1289	transmembrane transporter activity
ACZ76_06845	COG1566	PFAM secretion protein HlyD family protein
ACZ76_06855	COG0583	DNA-binding transcription factor activity
ACZ76_06860	COG0312	modulator of DNA gyrase
ACZ76_06865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACZ76_06870	COG3164	Protein of unknown function
ACZ76_06875	COG1530	ribonuclease E activity
ACZ76_06885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ACZ76_06890	COG1792	Involved in formation and maintenance of cell shape
ACZ76_06895	COG1077	Cell shape determining protein MreB Mrl
ACZ76_06900	COG2200	EAL domain
ACZ76_06900	COG2199	diguanylate cyclase activity
ACZ76_06905	COG0604	alcohol dehydrogenase
ACZ76_06915	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACZ76_06920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACZ76_06925	COG0511	ligase activity, forming carbon-carbon bonds
ACZ76_06930	COG0439	Biotin carboxylase
ACZ76_06935	COG3924	membrane
ACZ76_06940	COG4145	pantothenate transmembrane transporter activity
ACZ76_06945	COG2264	protein methyltransferase activity
ACZ76_06950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACZ76_06955	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ACZ76_06965	COG4626	Terminase
ACZ76_06965	COG1802	Transcriptional regulator
ACZ76_07055	COG3706	GGDEF domain
ACZ76_07060	COG3133	Outer membrane lipoprotein
ACZ76_07065	COG1278	Cold shock
ACZ76_07070	COG1278	Cold shock
ACZ76_07075	COG0471	metal ion transport
ACZ76_07085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACZ76_07095	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_07100	COG1129	ABC transporter
ACZ76_07110	COG1560	Kdo2-lipid A biosynthetic process
ACZ76_07115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_07120	COG4597	amino acid ABC transporter
ACZ76_07125	COG0765	amino acid transport
ACZ76_07130	COG1126	abc transporter atp-binding protein
ACZ76_07145	COG1380	Effector of murein hydrolase LrgA
ACZ76_07150	COG0583	DNA-binding transcription factor activity
ACZ76_07155	COG0025	NhaP-type Na H and K H
ACZ76_07165	COG2252	PERMEase
ACZ76_07175	COG0629	single-stranded DNA binding
ACZ76_07180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACZ76_07185	COG2315	Protein conserved in bacteria
ACZ76_07190	COG1448	Aminotransferase
ACZ76_07195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACZ76_07200	COG0305	Participates in initiation and elongation during chromosome replication
ACZ76_07220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACZ76_07225	COG0735	belongs to the Fur family
ACZ76_07230	COG3237	CsbD-like
ACZ76_07235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACZ76_07240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACZ76_07245	COG2937	Belongs to the GPAT DAPAT family
ACZ76_07250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACZ76_07255	COG3161	chorismate lyase activity
ACZ76_07270	COG4580	involved in the transport of maltose and maltodextrins
ACZ76_07285	COG1175	transmembrane transport
ACZ76_07290	COG3833	ABC-type maltose transport systems, permease component
ACZ76_07295	COG3223	Belongs to the PsiE family
ACZ76_07305	COG0527	aspartate kinase activity
ACZ76_07330	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
ACZ76_07335	COG2224	Isocitrate lyase
ACZ76_07340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACZ76_07345	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ACZ76_07390	COG0151	Belongs to the GarS family
ACZ76_07405	COG3068	Protein conserved in bacteria
ACZ76_07410	COG1515	deoxyribonuclease V activity
ACZ76_07420	COG2816	NAD+ diphosphatase activity
ACZ76_07425	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ACZ76_07430	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACZ76_07440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACZ76_07445	COG2104	thiamine diphosphate biosynthetic process
ACZ76_07450	COG2022	thiamine diphosphate biosynthetic process
ACZ76_07470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACZ76_07475	COG0085	RNA polymerase activity
ACZ76_07480	COG0222	ribosome binding
ACZ76_07485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACZ76_07490	COG0081	regulation of translation
ACZ76_07495	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACZ76_07500	COG0250	Participates in transcription elongation, termination and antitermination
ACZ76_07505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACZ76_07540	COG1072	(Pantothenic acid kinase))
ACZ76_07575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ACZ76_07580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACZ76_07585	COG0009	L-threonylcarbamoyladenylate synthase
ACZ76_07590	COG0551	DNA topoisomerase type I activity
ACZ76_07600	COG0758	DNA mediated transformation
ACZ76_07605	COG0242	peptide deformylase activity
ACZ76_07610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACZ76_07615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACZ76_07615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACZ76_07620	COG0569	domain protein
ACZ76_07625	COG1970	mechanosensitive ion channel activity
ACZ76_07630	COG3036	rescue of stalled ribosome
ACZ76_07635	COG0789	Transcriptional regulator
ACZ76_07645	COG0203	ribosomal protein L17
ACZ76_07655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACZ76_07660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACZ76_07665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACZ76_07670	COG0201	protein transport
ACZ76_07675	COG0200	Binds to the 23S rRNA
ACZ76_07680	COG1841	ribosomal large subunit assembly
ACZ76_07685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACZ76_07690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACZ76_07695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACZ76_07705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACZ76_07720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACZ76_07725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACZ76_07730	COG0255	Belongs to the universal ribosomal protein uL29 family
ACZ76_07735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACZ76_07740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACZ76_07745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACZ76_07750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACZ76_07755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACZ76_07760	COG0089	rRNA binding
ACZ76_07770	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACZ76_07775	COG0051	transcription antitermination factor activity, RNA binding
ACZ76_07785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACZ76_07795	COG0049	tRNA binding
ACZ76_07800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACZ76_07805	COG2168	tRNA wobble position uridine thiolation
ACZ76_07810	COG2923	Belongs to the DsrF TusC family
ACZ76_07815	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ACZ76_07820	COG2964	Protein conserved in bacteria
ACZ76_07825	COG0545	Peptidyl-prolyl cis-trans isomerase
ACZ76_07835	COG1047	Peptidyl-prolyl cis-trans
ACZ76_07840	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ACZ76_07850	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACZ76_07855	COG0488	(ABC) transporter
ACZ76_07860	COG1216	Glycosyl transferase, family 2
ACZ76_07865	COG2175	clavaminate synthase activity
ACZ76_07870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACZ76_07880	COG4521	taurine ABC transporter
ACZ76_07895	COG0429	hydrolase of the alpha beta-hydrolase fold
ACZ76_07900	COG3089	Belongs to the UPF0270 family
ACZ76_07905	COG3954	Phosphoribulokinase
ACZ76_07910	COG1765	OsmC-like protein
ACZ76_07920	COG1289	transmembrane transporter activity
ACZ76_07945	COG0433	COG0433 Predicted ATPase
ACZ76_07950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACZ76_07955	COG1486	melibiose metabolic process
ACZ76_07975	COG0738	Major facilitator superfamily
ACZ76_07980	COG0402	S-adenosylhomocysteine deaminase activity
ACZ76_07985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACZ76_07990	COG2146	nitrite reductase [NAD(P)H] activity
ACZ76_08000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACZ76_08000	COG1648	precorrin-2 dehydrogenase activity
ACZ76_08005	COG0180	Tryptophanyl-tRNA synthetase
ACZ76_08015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACZ76_08035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACZ76_08040	COG4796	Type ii and iii secretion system protein
ACZ76_08065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACZ76_08070	COG0494	nUDIX hydrolase
ACZ76_08080	COG1011	Hydrolase
ACZ76_08085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACZ76_08095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACZ76_08105	COG0745	RESPONSE REGULATOR receiver
ACZ76_08110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACZ76_08135	COG2183	response to ionizing radiation
ACZ76_08140	COG1918	ferrous iron import across plasma membrane
ACZ76_08160	COG0596	Alpha beta hydrolase
ACZ76_08170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACZ76_08170	COG0316	Belongs to the HesB IscA family
ACZ76_08175	COG1640	4-alpha-glucanotransferase
ACZ76_08180	COG0058	SHG alpha-glucan phosphorylase activity
ACZ76_08185	COG2909	trisaccharide binding
ACZ76_08200	COG0705	Rhomboid family
ACZ76_08205	COG1349	DNA-binding transcription factor activity
ACZ76_08210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACZ76_08215	COG0058	SHG alpha-glucan phosphorylase activity
ACZ76_08220	COG0297	glycogen (starch) synthase activity
ACZ76_08230	COG1523	belongs to the glycosyl hydrolase 13 family
ACZ76_08235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACZ76_08240	COG3275	phosphorelay sensor kinase activity
ACZ76_08260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACZ76_08265	COG2095	MarC family integral membrane protein
ACZ76_08270	COG3265	gluconokinase activity
ACZ76_08275	COG2610	gluconate transmembrane transporter activity
ACZ76_08280	COG1609	Transcriptional regulator
ACZ76_08285	COG1741	Belongs to the pirin family
ACZ76_08290	COG1247	-acetyltransferase
ACZ76_08295	COG1082	Xylose isomerase domain protein TIM barrel
ACZ76_08300	COG1082	Xylose isomerase domain protein TIM barrel
ACZ76_08305	COG0673	inositol 2-dehydrogenase activity
ACZ76_08315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACZ76_08325	COG3718	enzyme involved in inositol metabolism
ACZ76_08335	COG2814	Major facilitator Superfamily
ACZ76_08345	COG2814	Major facilitator Superfamily
ACZ76_08350	COG0583	DNA-binding transcription factor activity
ACZ76_08400	COG2081	HI0933 family
ACZ76_08405	COG0306	phosphate transporter
ACZ76_08415	COG0589	response to stress
ACZ76_08430	COG0742	ribosomal rna small subunit methyltransferase
ACZ76_08440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACZ76_08445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACZ76_08455	COG1295	ribonuclease BN
ACZ76_08460	COG2134	cdp-diacylglycerol pyrophosphatase
ACZ76_08465	COG2982	Protein involved in outer membrane biogenesis
ACZ76_08470	COG2200	EAL domain
ACZ76_08475	COG1942	4-Oxalocrotonate Tautomerase
ACZ76_08480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACZ76_08485	COG0612	Peptidase, M16
ACZ76_08490	COG1301	dicarboxylic acid transport
ACZ76_08500	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACZ76_08505	COG1561	YicC-like family, N-terminal region
ACZ76_08510	COG2423	ornithine cyclodeaminase activity
ACZ76_08530	COG3727	T/G mismatch-specific endonuclease activity
ACZ76_08540	COG0823	Involved in the tonB-independent uptake of proteins
ACZ76_08545	COG5645	(Lipo)protein
ACZ76_08560	COG2985	domain, Protein
ACZ76_08560	COG0569	domain protein
ACZ76_08565	COG3977	Valine--pyruvate aminotransferase
ACZ76_08570	COG0366	Alpha amylase catalytic
ACZ76_08590	COG2885	chlorophyll binding
ACZ76_08600	COG0456	acetyltransferase
ACZ76_08605	COG2818	Glycosylase
ACZ76_08620	COG0751	glycine-tRNA ligase activity
ACZ76_08630	COG2213	PTS system mannitol-specific
ACZ76_08630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_08635	COG0246	Mannitol dehydrogenase
ACZ76_08640	COG3722	fumarate hydratase activity
ACZ76_08650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACZ76_08670	COG2258	MOSC domain
ACZ76_08675	COG0840	transmembrane signaling receptor activity
ACZ76_08680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACZ76_08685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACZ76_08690	COG0243	molybdopterin cofactor binding
ACZ76_08690	COG3383	formate dehydrogenase (NAD+) activity
ACZ76_08695	COG0243	molybdopterin cofactor binding
ACZ76_08695	COG3383	formate dehydrogenase (NAD+) activity
ACZ76_08700	COG0437	4 iron, 4 sulfur cluster binding
ACZ76_08705	COG2864	formate dehydrogenase
ACZ76_08710	COG3058	Necessary for formate dehydrogenase activity
ACZ76_08715	COG1921	L-seryl-tRNASec selenium transferase activity
ACZ76_08720	COG3276	selenocysteine insertion sequence binding
ACZ76_08725	COG3622	Belongs to the hyi family
ACZ76_08730	COG0235	Class ii aldolase
ACZ76_08735	COG3395	kinase activity
ACZ76_08740	COG1349	DNA-binding transcription factor activity
ACZ76_08745	COG2271	Major facilitator Superfamily
ACZ76_08750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACZ76_08760	COG3274	enterobacterial common antigen metabolic process
ACZ76_08770	COG1335	isochorismatase
ACZ76_08780	COG3188	usher protein
ACZ76_08785	COG3121	Chaperone
ACZ76_08795	COG1070	Carbohydrate kinase
ACZ76_08800	COG2115	Belongs to the xylose isomerase family
ACZ76_08805	COG4213	ABC transporter substrate-binding protein
ACZ76_08815	COG4214	carbohydrate transport
ACZ76_08820	COG2207	Transcriptional regulator
ACZ76_08820	COG1609	Transcriptional regulator
ACZ76_08835	COG0561	phosphatase activity
ACZ76_08840	COG0187	DNA topoisomerase II activity
ACZ76_08850	COG0592	DNA-directed DNA polymerase activity
ACZ76_08855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACZ76_08860	COG0594	ribonuclease P activity
ACZ76_08865	COG0706	membrane insertase activity
ACZ76_08870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACZ76_08875	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACZ76_08885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACZ76_08890	COG2011	ABC-type metal ion transport system permease component
ACZ76_08895	COG0840	transmembrane signaling receptor activity
ACZ76_08900	COG0431	NADPH-dependent FMN reductase
ACZ76_08905	COG4191	Histidine kinase
ACZ76_08920	COG2252	PERMEase
ACZ76_08925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACZ76_08930	COG0765	amino acid transport
ACZ76_08935	COG0765	amino acid transport
ACZ76_08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_08950	COG0704	Plays a role in the regulation of phosphate uptake
ACZ76_08960	COG0581	inorganic phosphate transmembrane transporter activity
ACZ76_08965	COG0573	inorganic phosphate transmembrane transporter activity
ACZ76_08970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACZ76_08975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACZ76_08980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACZ76_08985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACZ76_08990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACZ76_09000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACZ76_09005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACZ76_09010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACZ76_09020	COG0356	it plays a direct role in the translocation of protons across the membrane
ACZ76_09025	COG3312	ion transport
ACZ76_09030	COG0357	Ribosomal RNA small subunit methyltransferase G
ACZ76_09035	COG0445	tRNA wobble uridine modification
ACZ76_09040	COG0716	FMN binding
ACZ76_09045	COG1522	sequence-specific DNA binding
ACZ76_09050	COG2502	aspartate--ammonia ligase
ACZ76_09060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ACZ76_09065	COG0714	Associated with various cellular activities
ACZ76_09070	COG3158	transport of potassium into the cell
ACZ76_09075	COG1869	D-ribose catabolic process
ACZ76_09080	COG1129	ABC transporter
ACZ76_09085	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_09090	COG1879	ABC-type sugar transport system periplasmic component
ACZ76_09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACZ76_09100	COG1609	Transcriptional regulator
ACZ76_09105	COG0477	Major facilitator Superfamily
ACZ76_09110	COG2186	Transcriptional regulator
ACZ76_09135	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACZ76_09145	COG3084	Protein conserved in bacteria
ACZ76_09150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACZ76_09155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACZ76_09160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACZ76_09160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACZ76_09165	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACZ76_09170	COG3078	GTPase activator activity
ACZ76_09175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACZ76_09185	COG3852	Histidine kinase
ACZ76_09190	COG0174	glutamine synthetase
ACZ76_09200	COG1011	Hydrolase
ACZ76_09205	COG1295	ribonuclease BN
ACZ76_09210	COG1490	D-aminoacyl-tRNA deacylase activity
ACZ76_09215	COG0456	acetyltransferase
ACZ76_09230	COG2204	response regulator
ACZ76_09245	COG3423	Transcriptional regulator
ACZ76_09270	COG2982	Protein involved in outer membrane biogenesis
ACZ76_09275	COG2233	PERMEase
ACZ76_09280	COG0786	glutamate:sodium symporter activity
ACZ76_09285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACZ76_09290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACZ76_09295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACZ76_09300	COG1758	RNA polymerase activity
ACZ76_09310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACZ76_09315	COG2860	membrane
ACZ76_09325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACZ76_09330	COG1024	Enoyl-CoA hydratase
ACZ76_09335	COG5001	Diguanylate cyclase
ACZ76_09340	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACZ76_09345	COG2986	histidine ammonia-lyase
ACZ76_09360	COG1764	response to oxidative stress
ACZ76_09365	COG2194	sulfuric ester hydrolase activity
ACZ76_09370	COG2197	response regulator
ACZ76_09375	COG3851	Histidine kinase
ACZ76_09380	COG2271	Major facilitator Superfamily
ACZ76_09390	COG2831	hemolysin activation secretion protein
ACZ76_09395	COG3210	domain, Protein
ACZ76_09400	COG0747	negative chemotaxis
ACZ76_09405	COG0601	transmembrane transport
ACZ76_09410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACZ76_09415	COG0444	Belongs to the ABC transporter superfamily
ACZ76_09420	COG4608	Belongs to the ABC transporter superfamily
ACZ76_09425	COG2194	sulfuric ester hydrolase activity
ACZ76_09445	COG1192	Involved in chromosome partitioning
ACZ76_09455	COG1215	transferase activity, transferring glycosyl groups
ACZ76_09465	COG0457	Tetratricopeptide repeat
ACZ76_09465	COG3118	belongs to the thioredoxin family
ACZ76_09470	COG2200	EAL domain
ACZ76_09470	COG2199	diguanylate cyclase activity
ACZ76_09475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACZ76_09485	COG1309	transcriptional regulator
ACZ76_09490	COG0756	dUTP diphosphatase activity
ACZ76_09495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACZ76_09505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACZ76_09510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACZ76_09530	COG1519	Transferase
ACZ76_09535	COG0859	PFAM glycosyl transferase family 9
ACZ76_09540	COG0859	PFAM glycosyl transferase family 9
ACZ76_09545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACZ76_09550	COG0156	8-amino-7-oxononanoate synthase activity
ACZ76_09560	COG2861	carbohydrate metabolic process
ACZ76_09565	COG4942	peptidase
ACZ76_09570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACZ76_09575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACZ76_09580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACZ76_09585	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACZ76_09590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACZ76_09600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACZ76_09605	COG2169	Transcriptional regulator
ACZ76_09605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACZ76_09610	COG2205	protein histidine kinase activity
ACZ76_09615	COG0745	RESPONSE REGULATOR receiver
ACZ76_09620	COG3678	ATP-independent chaperone mediated protein folding
ACZ76_09625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ACZ76_09635	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACZ76_09655	COG3152	Membrane
ACZ76_09665	COG0460	homoserine dehydrogenase
ACZ76_09665	COG0527	aspartate kinase activity
ACZ76_09670	COG0626	cystathionine gamma-synthase activity
ACZ76_09675	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ACZ76_09680	COG0254	rRNA binding
ACZ76_09685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACZ76_09690	COG1609	Transcriptional regulator
ACZ76_09695	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACZ76_09700	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACZ76_09705	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACZ76_09710	COG1575	Belongs to the MenA family. Type 1 subfamily
ACZ76_09715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACZ76_09720	COG3074	FtsZ-dependent cytokinesis
ACZ76_09725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACZ76_09730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACZ76_09735	COG1494	fructose-1,6-bisphosphatase
ACZ76_09740	COG2814	Major facilitator Superfamily
ACZ76_09750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACZ76_09760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACZ76_09765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACZ76_09770	COG0165	Argininosuccinate lyase
ACZ76_09805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACZ76_09810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACZ76_09810	COG0678	peroxiredoxin activity
ACZ76_09820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACZ76_09825	COG1309	transcriptional regulator
ACZ76_09835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACZ76_09845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACZ76_09885	COG1879	ABC-type sugar transport system periplasmic component
ACZ76_09890	COG1129	ABC transporter
ACZ76_09895	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_09900	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_09905	COG0583	DNA-binding transcription factor activity
ACZ76_09910	COG3085	chromosome segregation
ACZ76_09925	COG3978	acetolactate synthase activity
ACZ76_09930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACZ76_09935	COG0129	dihydroxy-acid dehydratase activity
ACZ76_09940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACZ76_09955	COG0583	DNA-binding transcription factor activity
ACZ76_09960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACZ76_10000	COG3121	Chaperone
ACZ76_10015	COG3121	Chaperone
ACZ76_10025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACZ76_10040	COG0248	Ppx GppA phosphatase
ACZ76_10050	COG3118	belongs to the thioredoxin family
ACZ76_10055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACZ76_10060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACZ76_10065	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ACZ76_10070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACZ76_10075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACZ76_10080	COG1088	dTDP-glucose 4,6-dehydratase activity
ACZ76_10085	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ACZ76_10090	COG0456	acetyltransferase
ACZ76_10095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACZ76_10100	COG2244	polysaccharide biosynthetic process
ACZ76_10105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACZ76_10120	COG1113	amino acid transport
ACZ76_10145	COG3071	HemY protein
ACZ76_10150	COG2959	enzyme of heme biosynthesis
ACZ76_10155	COG1587	Uroporphyrinogen-III synthase
ACZ76_10160	COG0181	hydroxymethylbilane synthase activity
ACZ76_10165	COG3072	Adenylate cyclase
ACZ76_10170	COG1965	Belongs to the frataxin family
ACZ76_10175	COG5567	small periplasmic lipoprotein
ACZ76_10180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACZ76_10185	COG3159	Protein conserved in bacteria
ACZ76_10190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACZ76_10195	COG1011	Hydrolase
ACZ76_10200	COG0210	DNA helicase
ACZ76_10210	COG5441	Belongs to the UPF0261 family
ACZ76_10215	COG5564	TIM-barrel signal transduction protein
ACZ76_10225	COG0598	Magnesium transport protein CorA
ACZ76_10235	COG2050	protein possibly involved in aromatic compounds catabolism
ACZ76_10240	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ACZ76_10250	COG1280	lysine exporter protein (LysE YggA)
ACZ76_10260	COG2267	carboxylic ester hydrolase activity
ACZ76_10265	COG0561	phosphatase activity
ACZ76_10270	COG0584	glycerophosphoryl diester phosphodiesterase
ACZ76_10275	COG2271	Major facilitator Superfamily
ACZ76_10280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ACZ76_10290	COG0247	lactate metabolic process
ACZ76_10300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACZ76_10305	COG0425	Belongs to the sulfur carrier protein TusA family
ACZ76_10315	COG3714	YhhN family
ACZ76_10330	COG3776	membrane
ACZ76_10335	COG0742	ribosomal rna small subunit methyltransferase
ACZ76_10340	COG0552	protein localization to endoplasmic reticulum
ACZ76_10340	COG0552	protein localization to endoplasmic reticulum
ACZ76_10345	COG2884	Cell division ATP-binding protein ftsE
ACZ76_10350	COG2177	Part of the ABC transporter FtsEX involved in
ACZ76_10360	COG0456	acetyltransferase
ACZ76_10365	COG0683	leucine binding
ACZ76_10370	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACZ76_10375	COG4177	L-phenylalanine transmembrane transporter activity
ACZ76_10380	COG0411	ABC transporter
ACZ76_10385	COG0410	ABC transporter
ACZ76_10430	COG1653	transport
ACZ76_10435	COG1175	transmembrane transport
ACZ76_10440	COG0395	ABC-type sugar transport system, permease component
ACZ76_10445	COG3842	ATPase activity
ACZ76_10450	COG0584	glycerophosphoryl diester phosphodiesterase
ACZ76_10455	COG0679	Auxin Efflux Carrier
ACZ76_10470	COG0583	DNA-binding transcription factor activity
ACZ76_10475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACZ76_10480	COG0412	Dienelactone hydrolase
ACZ76_10485	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ACZ76_10495	COG1966	Carbon starvation protein
ACZ76_10500	COG0586	Pfam SNARE associated Golgi protein
ACZ76_10505	COG1322	Protein conserved in bacteria
ACZ76_10510	COG2226	methyltransferase
ACZ76_10520	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACZ76_10525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACZ76_10530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACZ76_10535	COG0805	protein transport
ACZ76_10555	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACZ76_10560	COG0543	2 iron, 2 sulfur cluster binding
ACZ76_10565	COG0183	Belongs to the thiolase family
ACZ76_10570	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACZ76_10570	COG1024	Enoyl-CoA hydratase
ACZ76_10580	COG1739	Uncharacterized protein family UPF0029
ACZ76_10585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACZ76_10620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACZ76_10625	COG3162	membrane
ACZ76_10630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACZ76_10635	COG1301	dicarboxylic acid transport
ACZ76_10645	COG5002	protein histidine kinase activity
ACZ76_10645	COG0784	Response regulator, receiver
ACZ76_10645	COG2205	protein histidine kinase activity
ACZ76_10805	COG3264	Mechanosensitive ion channel
ACZ76_10805	COG1196	nuclear chromosome segregation
ACZ76_10810	COG4774	siderophore transport
ACZ76_10820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACZ76_10825	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ACZ76_10830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACZ76_10835	COG4558	Periplasmic binding protein
ACZ76_10840	COG3720	iron ion transport
ACZ76_10855	COG0702	epimerase
ACZ76_10860	COG3721	Heme iron utilization protein
ACZ76_10870	COG1215	transferase activity, transferring glycosyl groups
ACZ76_10885	COG0463	Glycosyl transferase, family 2
ACZ76_10915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACZ76_10920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACZ76_10920	COG0543	2 iron, 2 sulfur cluster binding
ACZ76_10930	COG2826	transposase and inactivated derivatives, IS30 family
ACZ76_10945	COG1309	transcriptional regulator
ACZ76_10955	COG2084	Dehydrogenase
ACZ76_10960	COG1929	Belongs to the glycerate kinase type-1 family
ACZ76_10965	COG3835	regulator
ACZ76_10970	COG2721	sulfolactate sulfo-lyase activity
ACZ76_10975	COG2271	Major facilitator Superfamily
ACZ76_10980	COG0493	'glutamate synthase
ACZ76_10980	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACZ76_10985	COG4232	protein-disulfide reductase activity
ACZ76_11010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACZ76_11015	COG0459	protein refolding
ACZ76_11040	COG2076	Multidrug Resistance protein
ACZ76_11050	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ACZ76_11055	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ACZ76_11060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACZ76_11065	COG1053	succinate dehydrogenase
ACZ76_11070	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ACZ76_11075	COG3264	Mechanosensitive ion channel
ACZ76_11075	COG1511	domain protein
ACZ76_11080	COG0688	phosphatidylethanolamine metabolic process
ACZ76_11085	COG1162	GTPase activity
ACZ76_11090	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACZ76_11110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACZ76_11115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACZ76_11115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACZ76_11120	COG0802	atpase or kinase
ACZ76_11125	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACZ76_11130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACZ76_11140	COG1923	regulation of RNA biosynthetic process
ACZ76_11145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACZ76_11150	COG0330	HflC and HflK could
ACZ76_11155	COG0330	HflC and HflK could
ACZ76_11160	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ACZ76_11165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACZ76_11170	COG1959	2 iron, 2 sulfur cluster binding
ACZ76_11175	COG0557	exoribonuclease II activity
ACZ76_11180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACZ76_11185	COG1960	acyl-CoA dehydrogenase activity
ACZ76_11190	COG3650	response to hydrogen peroxide
ACZ76_11195	COG1073	alpha beta
ACZ76_11205	COG0360	Binds together with S18 to 16S ribosomal RNA
ACZ76_11215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACZ76_11230	COG3061	Opacity-associated protein A
ACZ76_11235	COG0545	Peptidyl-prolyl cis-trans isomerase
ACZ76_11245	COG0737	Belongs to the 5'-nucleotidase family
ACZ76_11250	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACZ76_11255	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ACZ76_11265	COG1253	flavin adenine dinucleotide binding
ACZ76_11270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACZ76_11280	COG2911	Protein conserved in bacteria
ACZ76_11285	COG2105	PFAM AIG2 family protein
ACZ76_11310	COG0438	transferase activity, transferring glycosyl groups
ACZ76_11330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACZ76_11340	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACZ76_11345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACZ76_11365	COG3423	Transcriptional regulator
ACZ76_11375	COG0142	geranyltranstransferase activity
ACZ76_11390	COG0697	spore germination
ACZ76_11400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACZ76_11405	COG0642	Histidine kinase
ACZ76_11410	COG0745	RESPONSE REGULATOR receiver
ACZ76_11415	COG2027	D-alanyl-D-alanine carboxypeptidase
ACZ76_11420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACZ76_11425	COG1534	Rna-binding protein
ACZ76_11430	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACZ76_11435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACZ76_11440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACZ76_11450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACZ76_11470	COG0195	Participates in both transcription termination and antitermination
ACZ76_11480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACZ76_11485	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACZ76_11495	COG1185	polyribonucleotide nucleotidyltransferase activity
ACZ76_11505	COG0513	Belongs to the DEAD box helicase family
ACZ76_11515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACZ76_11525	COG0814	amino acid
ACZ76_11530	COG3681	Belongs to the UPF0597 family
ACZ76_11550	COG3153	acetyltransferase
ACZ76_11555	COG2827	Endonuclease containing a URI domain
ACZ76_11560	COG0531	amino acid
ACZ76_11565	COG1982	Orn Lys Arg decarboxylase major
ACZ76_11580	COG1653	transport
ACZ76_11590	COG0395	ABC-type sugar transport system, permease component
ACZ76_11595	COG3842	ATPase activity
ACZ76_11605	COG3787	Belongs to the UPF0306 family
ACZ76_11610	COG0702	epimerase
ACZ76_11615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACZ76_11620	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ACZ76_11625	COG3454	Phosphonate metabolism
ACZ76_11630	COG4778	phosphonate C-P lyase system protein PhnL
ACZ76_11635	COG4107	phosphonate C-P lyase system protein PhnK
ACZ76_11640	COG3627	carbon phosphorus lyase activity
ACZ76_11645	COG3626	phosphonate metabolism
ACZ76_11650	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ACZ76_11655	COG3624	Phosphonate C-P lyase system protein PhnG
ACZ76_11660	COG2188	Transcriptional regulator
ACZ76_11675	COG0602	queuosine metabolic process
ACZ76_11695	COG4608	Belongs to the ABC transporter superfamily
ACZ76_11700	COG0444	Belongs to the ABC transporter superfamily
ACZ76_11705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACZ76_11710	COG0601	transmembrane transport
ACZ76_11720	COG2731	YhcH YjgK YiaL family protein
ACZ76_11730	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ACZ76_11745	COG2927	DNA polymerase III (CHI subunit)
ACZ76_11750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACZ76_11755	COG0795	lipopolysaccharide-transporting ATPase activity
ACZ76_11760	COG0795	lipopolysaccharide-transporting ATPase activity
ACZ76_11770	COG2963	transposase activity
ACZ76_11775	COG2826	transposase and inactivated derivatives, IS30 family
ACZ76_11800	COG3423	Transcriptional regulator
ACZ76_11825	COG1879	ABC-type sugar transport system periplasmic component
ACZ76_11830	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_11835	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_11840	COG1129	ABC transporter
ACZ76_11845	COG2390	Transcriptional regulator
ACZ76_11850	COG1070	Carbohydrate kinase
ACZ76_11855	COG0859	PFAM glycosyl transferase family 9
ACZ76_11870	COG2235	arginine
ACZ76_11875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_11880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACZ76_11890	COG2376	Dihydroxyacetone kinase
ACZ76_11895	COG1461	Dihydroxyacetone kinase
ACZ76_11900	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ACZ76_11900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACZ76_11900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_11910	COG2192	nodulation
ACZ76_11945	COG4772	TonB-dependent receptor
ACZ76_11950	COG3706	GGDEF domain
ACZ76_11980	COG0667	Aldo Keto reductase
ACZ76_11985	COG2813	Specifically methylates the guanine in position
ACZ76_11990	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ACZ76_12000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACZ76_12005	COG2823	Periplasmic or secreted lipoprotein
ACZ76_12010	COG4667	esterase of the alpha-beta hydrolase superfamily
ACZ76_12015	COG0084	hydrolase, TatD family'
ACZ76_12020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACZ76_12025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACZ76_12035	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ACZ76_12045	COG3550	peptidyl-serine autophosphorylation
ACZ76_12050	COG3726	membrane protein affecting hemolysin expression
ACZ76_12055	COG0560	Phosphoserine phosphatase
ACZ76_12070	COG0604	alcohol dehydrogenase
ACZ76_12075	COG0583	DNA-binding transcription factor activity
ACZ76_12085	COG0488	(ABC) transporter
ACZ76_12090	COG2885	chlorophyll binding
ACZ76_12095	COG2199	diguanylate cyclase activity
ACZ76_12105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACZ76_12110	COG0741	lytic transglycosylase activity
ACZ76_12115	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ACZ76_12120	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ACZ76_12130	COG3708	Transcriptional regulator
ACZ76_12130	COG2207	Transcriptional regulator
ACZ76_12135	COG3045	CreA protein
ACZ76_12140	COG0745	RESPONSE REGULATOR receiver
ACZ76_12145	COG2826	transposase and inactivated derivatives, IS30 family
ACZ76_12155	COG0083	homoserine kinase activity
ACZ76_12165	COG3022	response to hydroperoxide
ACZ76_12170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACZ76_12175	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACZ76_12180	COG0477	Major facilitator Superfamily
ACZ76_12190	COG1584	GPR1 FUN34 yaaH family protein
ACZ76_12200	COG0484	heat shock protein binding
ACZ76_12205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ACZ76_12210	COG0583	DNA-binding transcription factor activity
ACZ76_12220	COG0196	riboflavin kinase activity
ACZ76_12225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACZ76_12230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACZ76_12235	COG1047	Peptidyl-prolyl cis-trans
ACZ76_12240	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACZ76_12245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACZ76_12250	COG0505	Belongs to the CarA family
ACZ76_12255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACZ76_12260	COG1280	lysine exporter protein (LysE YggA)
ACZ76_12265	COG2966	Psort location CytoplasmicMembrane, score
ACZ76_12275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACZ76_12280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACZ76_12285	COG2967	ApaG domain
ACZ76_12290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACZ76_12300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACZ76_12305	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACZ76_12310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACZ76_12320	COG0564	pseudouridine synthase activity
ACZ76_12330	COG0417	DNA replication proofreading
ACZ76_12335	COG0586	Pfam SNARE associated Golgi protein
ACZ76_12345	COG1178	ABC-type Fe3 transport system permease component
ACZ76_12350	COG4143	(ABC) transporter
ACZ76_12355	COG4533	DNA binding
ACZ76_12360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ACZ76_12370	COG2814	Major facilitator Superfamily
ACZ76_12380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACZ76_12385	COG0473	3-isopropylmalate dehydrogenase activity
ACZ76_12400	COG1022	Amp-dependent synthetase and ligase
ACZ76_12405	COG0028	Belongs to the TPP enzyme family
ACZ76_12415	COG1609	Transcriptional regulator
ACZ76_12430	COG0275	rRNA processing
ACZ76_12435	COG3116	cell division
ACZ76_12440	COG0768	penicillin binding
ACZ76_12445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACZ76_12450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACZ76_12455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACZ76_12465	COG0772	Belongs to the SEDS family
ACZ76_12470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACZ76_12475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACZ76_12485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACZ76_12490	COG0849	cell division
ACZ76_12495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACZ76_12515	COG0653	protein targeting
ACZ76_12520	COG0494	nUDIX hydrolase
ACZ76_12525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACZ76_12535	COG0237	dephospho-CoA kinase activity
ACZ76_12540	COG0516	GMP reductase activity
ACZ76_12545	COG1459	type II secretion system
ACZ76_12550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACZ76_12555	COG4969	Belongs to the N-Me-Phe pilin family
ACZ76_12565	COG3023	N-Acetylmuramoyl-L-alanine amidase
ACZ76_12570	COG3725	Membrane protein required for beta-lactamase induction
ACZ76_12575	COG3940	Belongs to the glycosyl hydrolase 43 family
ACZ76_12580	COG2211	Major facilitator Superfamily
ACZ76_12585	COG1113	amino acid transport
ACZ76_12590	COG2186	Transcriptional regulator
ACZ76_12595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACZ76_12600	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACZ76_12605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACZ76_12615	COG2207	Transcriptional regulator
ACZ76_12630	COG3112	Uncharacterised protein family (UPF0231)
ACZ76_12635	COG0697	spore germination
ACZ76_12665	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACZ76_12675	COG2132	Multicopper oxidase
ACZ76_12685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACZ76_12690	COG0288	reversible hydration of carbon dioxide
ACZ76_12695	COG1131	(ABC) transporter
ACZ76_12700	COG0842	Transport permease protein
ACZ76_12705	COG0726	polysaccharide deacetylase
ACZ76_12710	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACZ76_12715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACZ76_12720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACZ76_12725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACZ76_12730	COG0617	tRNA 3'-terminal CCA addition
ACZ76_12740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACZ76_12745	COG1489	DNA binding
ACZ76_12750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ACZ76_12755	COG1643	Atp-dependent helicase
ACZ76_12760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACZ76_12765	COG1120	ATPase activity
ACZ76_12770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACZ76_12775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACZ76_12785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACZ76_12795	COG0316	Belongs to the HesB IscA family
ACZ76_12805	COG2860	membrane
ACZ76_12815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACZ76_12820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACZ76_12825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACZ76_12835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACZ76_12840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACZ76_12845	COG3956	TIGRFAM MazG family protein
ACZ76_12850	COG0504	CTP synthase activity
ACZ76_12855	COG0148	phosphopyruvate hydratase activity
ACZ76_12865	COG0602	queuosine metabolic process
ACZ76_12870	COG0720	synthase
ACZ76_12875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACZ76_12880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACZ76_12885	COG0175	sulfate reduction
ACZ76_12900	COG2234	aminopeptidase activity
ACZ76_12905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACZ76_12905	COG1648	precorrin-2 dehydrogenase activity
ACZ76_12910	COG0175	sulfate reduction
ACZ76_12915	COG2895	sulfate adenylyltransferase (ATP) activity
ACZ76_12920	COG0529	Catalyzes the synthesis of activated sulfate
ACZ76_12930	COG0698	ribose 5-phosphate isomerase
ACZ76_12935	COG1063	alcohol dehydrogenase
ACZ76_12940	COG2814	Major facilitator Superfamily
ACZ76_12945	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_12950	COG2376	Dihydroxyacetone kinase
ACZ76_12955	COG1461	Dihydroxyacetone kinase
ACZ76_12960	COG2390	Transcriptional regulator
ACZ76_12970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ACZ76_12980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACZ76_12985	COG0585	pseudouridine synthase activity
ACZ76_12990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACZ76_12995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACZ76_13000	COG4942	peptidase
ACZ76_13000	COG1388	LysM domain
ACZ76_13005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACZ76_13010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACZ76_13035	COG3188	usher protein
ACZ76_13040	COG3121	Chaperone
ACZ76_13050	COG3539	Fimbrial protein
ACZ76_13085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_13095	COG1538	Outer membrane efflux protein
ACZ76_13115	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_13120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_13125	COG4948	Mandelate Racemase Muconate Lactonizing
ACZ76_13135	COG0601	transmembrane transport
ACZ76_13145	COG0444	Belongs to the ABC transporter superfamily
ACZ76_13150	COG4608	Belongs to the ABC transporter superfamily
ACZ76_13160	COG0765	amino acid transport
ACZ76_13165	COG0765	amino acid transport
ACZ76_13170	COG1126	abc transporter atp-binding protein
ACZ76_13175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACZ76_13190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACZ76_13195	COG0640	Transcriptional regulator
ACZ76_13210	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACZ76_13210	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACZ76_13215	COG1349	DNA-binding transcription factor activity
ACZ76_13225	COG1070	Carbohydrate kinase
ACZ76_13235	COG0738	Major facilitator superfamily
ACZ76_13240	COG0235	Class ii aldolase
ACZ76_13245	COG1454	alcohol dehydrogenase
ACZ76_13250	COG0243	molybdopterin cofactor binding
ACZ76_13255	COG0437	4 iron, 4 sulfur cluster binding
ACZ76_13260	COG3302	dmso reductase anchor subunit
ACZ76_13265	COG3381	protein complex oligomerization
ACZ76_13290	COG1129	ABC transporter
ACZ76_13295	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACZ76_13300	COG3959	Transketolase, thiamine diphosphate binding domain
ACZ76_13305	COG3958	Transketolase
ACZ76_13310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACZ76_13335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACZ76_13340	COG2137	regulation of response to DNA damage stimulus
ACZ76_13345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACZ76_13350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACZ76_13375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACZ76_13380	COG1238	metal cluster binding
ACZ76_13385	COG2918	glutathione biosynthetic process
ACZ76_13390	COG1854	S-ribosylhomocysteine lyase activity
ACZ76_13395	COG4536	flavin adenine dinucleotide binding
ACZ76_13400	COG4137	Cytochrome C assembly protein
ACZ76_13405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACZ76_13415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACZ76_13425	COG0335	large ribosomal subunit rRNA binding
ACZ76_13430	COG3137	Salt-induced outer membrane protein
ACZ76_13435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACZ76_13440	COG3279	Response regulator of the LytR AlgR family
ACZ76_13445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACZ76_13450	COG0287	Prephenate dehydrogenase
ACZ76_13450	COG1605	Chorismate mutase
ACZ76_13455	COG0077	Prephenate dehydratase
ACZ76_13455	COG1605	Chorismate mutase
ACZ76_13460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACZ76_13465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACZ76_13470	COG0564	pseudouridine synthase activity
ACZ76_13480	COG0542	response to heat
ACZ76_13515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACZ76_13520	COG0045	succinate-CoA ligase (ADP-forming) activity
ACZ76_13520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACZ76_13520	COG1042	CoA-binding domain protein
ACZ76_13530	COG3118	belongs to the thioredoxin family
ACZ76_13535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACZ76_13540	COG2814	Major facilitator Superfamily
ACZ76_13545	COG1566	PFAM secretion protein HlyD family protein
ACZ76_13550	COG1538	Outer membrane efflux protein
ACZ76_13555	COG1846	Transcriptional regulator
ACZ76_13565	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACZ76_13570	COG2814	Major facilitator Superfamily
ACZ76_13575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACZ76_13585	COG0436	Aminotransferase
ACZ76_13590	COG0235	Class ii aldolase
ACZ76_13600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ACZ76_13610	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ACZ76_13625	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ACZ76_13630	COG1960	acyl-CoA dehydrogenase activity
ACZ76_13640	COG0121	glutamine amidotransferase
ACZ76_13645	COG3034	peptidoglycan biosynthetic process
ACZ76_13650	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACZ76_13655	COG1805	sodium ion transport
ACZ76_13660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACZ76_13665	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACZ76_13670	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACZ76_13675	COG2871	sodium ion transport
ACZ76_13680	COG1477	protein flavinylation
ACZ76_13685	COG2991	Protein conserved in bacteria
ACZ76_13695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACZ76_13700	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACZ76_13720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACZ76_13725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACZ76_13745	COG2226	methyltransferase
ACZ76_13770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACZ76_13775	COG3123	guanosine phosphorylase activity
ACZ76_13780	COG2974	May be involved in recombination
ACZ76_13785	COG1940	carbohydrate kinase activity
ACZ76_13790	COG0419	ATPase involved in DNA repair
ACZ76_13795	COG0420	3'-5' exonuclease activity
ACZ76_13800	COG0745	RESPONSE REGULATOR receiver
ACZ76_13805	COG5002	protein histidine kinase activity
ACZ76_13815	COG1114	Component of the transport system for branched-chain amino acids
ACZ76_13820	COG1113	amino acid transport
ACZ76_13825	COG0366	Alpha amylase catalytic
ACZ76_13840	COG0450	alkyl hydroperoxide reductase
ACZ76_13845	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ACZ76_13850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACZ76_13855	COG0343	queuine tRNA-ribosyltransferase activity
ACZ76_13860	COG1862	Preprotein translocase
ACZ76_13865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACZ76_13870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACZ76_13885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACZ76_13890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACZ76_13890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACZ76_13895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACZ76_13905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACZ76_13910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACZ76_13915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACZ76_13920	COG0142	geranyltranstransferase activity
ACZ76_13925	COG1722	exodeoxyribonuclease VII activity
ACZ76_13930	COG0301	tRNA thio-modification
ACZ76_13930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACZ76_13935	COG0693	protein deglycase activity
ACZ76_13940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACZ76_13945	COG1666	GTP binding
ACZ76_13950	COG2814	Major facilitator Superfamily
ACZ76_13955	COG0109	protoheme IX farnesyltransferase activity
ACZ76_13960	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACZ76_13965	COG1845	cytochrome c oxidase, subunit III
ACZ76_13970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACZ76_13975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACZ76_13985	COG2223	nitrite transmembrane transporter activity
ACZ76_13990	COG3056	Lipoprotein
ACZ76_13995	COG0271	Belongs to the BolA IbaG family
ACZ76_14000	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACZ76_14005	COG0740	serine-type endopeptidase activity
ACZ76_14010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACZ76_14015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACZ76_14020	COG0776	regulation of translation
ACZ76_14025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACZ76_14030	COG1555	photosystem II stabilization
ACZ76_14035	COG0824	Thioesterase
ACZ76_14040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACZ76_14045	COG4533	DNA binding
ACZ76_14050	COG0561	phosphatase activity
ACZ76_14060	COG1522	sequence-specific DNA binding
ACZ76_14065	COG1132	(ABC) transporter
ACZ76_14070	COG1132	(ABC) transporter
ACZ76_14075	COG0347	Belongs to the P(II) protein family
ACZ76_14080	COG0004	ammonium transporteR
ACZ76_14085	COG1946	Acyl-CoA thioesterase
ACZ76_14090	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ACZ76_14095	COG3695	enzyme binding
ACZ76_14115	COG1121	(ABC) transporter
ACZ76_14120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACZ76_14125	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACZ76_14130	COG0254	rRNA binding
ACZ76_14145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ACZ76_14150	COG3457	Alanine racemase
ACZ76_14160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACZ76_14165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_14170	COG1309	transcriptional regulator
ACZ76_14175	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ACZ76_14180	COG3264	Mechanosensitive ion channel
ACZ76_14180	COG1196	nuclear chromosome segregation
ACZ76_14190	COG2832	Protein of unknown function (DUF454)
ACZ76_14195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACZ76_14210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACZ76_14215	COG0326	Molecular chaperone. Has ATPase activity
ACZ76_14220	COG0563	adenylate kinase activity
ACZ76_14225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACZ76_14245	COG2963	transposase activity
ACZ76_14280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACZ76_14295	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ACZ76_14300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACZ76_14305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACZ76_14305	COG4651	solute:proton antiporter activity
ACZ76_14310	COG2223	nitrite transmembrane transporter activity
ACZ76_14315	COG0737	Belongs to the 5'-nucleotidase family
ACZ76_14320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACZ76_14325	COG3735	TraB family
ACZ76_14330	COG2217	Heavy metal translocating P-type atpase
ACZ76_14335	COG0789	Transcriptional regulator
ACZ76_14340	COG1585	Membrane protein implicated in regulation of membrane protease activity
ACZ76_14345	COG0330	HflC and HflK could
ACZ76_14350	COG3118	belongs to the thioredoxin family
ACZ76_14355	COG0300	oxidoreductase activity
ACZ76_14360	COG2755	lipolytic protein G-D-S-L family
ACZ76_14365	COG4181	ATPase activity
ACZ76_14370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ACZ76_14375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACZ76_14380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACZ76_14385	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACZ76_14390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACZ76_14395	COG0215	cysteine-tRNA ligase activity
ACZ76_14400	COG2501	S4 domain
ACZ76_14405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACZ76_14435	COG5444	nuclease activity
ACZ76_14455	COG2801	Transposase and inactivated derivatives
ACZ76_14465	COG3210	domain, Protein
ACZ76_14470	COG2831	hemolysin activation secretion protein
ACZ76_14475	COG2140	Oxalate decarboxylase
ACZ76_14485	COG3716	PTS system mannose fructose sorbose family IID component
ACZ76_14490	COG3715	PTS system
ACZ76_14495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_14495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_14510	COG1609	Transcriptional regulator
ACZ76_14520	COG2850	peptidyl-arginine hydroxylation
ACZ76_14525	COG5265	(ABC) transporter
ACZ76_14540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACZ76_14550	COG2197	response regulator
ACZ76_14555	COG1278	Cold shock
ACZ76_14560	COG1278	Cold shock
ACZ76_14565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACZ76_14570	COG3706	GGDEF domain
ACZ76_14575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACZ76_14580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACZ76_14585	COG0321	lipoyl(octanoyl) transferase activity
ACZ76_14590	COG2921	Belongs to the UPF0250 family
ACZ76_14595	COG1686	Belongs to the peptidase S11 family
ACZ76_14600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACZ76_14605	COG0772	Belongs to the SEDS family
ACZ76_14610	COG0768	penicillin binding
ACZ76_14620	COG0799	negative regulation of ribosome biogenesis
ACZ76_14625	COG0582	viral genome integration into host DNA
ACZ76_14685	COG4712	double-strand break repair protein
ACZ76_14730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACZ76_14750	COG0305	Participates in initiation and elongation during chromosome replication
ACZ76_14840	COG1783	phage Terminase large subunit
ACZ76_14910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACZ76_14915	COG1466	dna polymerase III delta subunit
ACZ76_14920	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ACZ76_14930	COG2888	peptidyl-tyrosine sulfation
ACZ76_14940	COG1126	abc transporter atp-binding protein
ACZ76_14945	COG0765	amino acid transport
ACZ76_14950	COG0765	amino acid transport
ACZ76_14965	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACZ76_14970	COG4535	Mg2 and Co2 transporter CorC
ACZ76_14975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACZ76_14980	COG1702	phosphate starvation-inducible protein PhoH
ACZ76_14985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACZ76_14990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACZ76_15025	COG0367	asparagine synthase
ACZ76_15030	COG0647	UMP catabolic process
ACZ76_15035	COG1846	Transcriptional regulator
ACZ76_15035	COG1940	carbohydrate kinase activity
ACZ76_15040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACZ76_15050	COG1263	PTS System
ACZ76_15050	COG2190	(PTS) system
ACZ76_15050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_15055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACZ76_15085	COG0735	belongs to the Fur family
ACZ76_15095	COG0840	transmembrane signaling receptor activity
ACZ76_15105	COG0596	Alpha beta hydrolase
ACZ76_15110	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ACZ76_15115	COG0033	Phosphoglucomutase
ACZ76_15130	COG0745	RESPONSE REGULATOR receiver
ACZ76_15135	COG2205	protein histidine kinase activity
ACZ76_15140	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACZ76_15145	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACZ76_15150	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACZ76_15165	COG3272	Protein of unknown function (DUF1722)
ACZ76_15175	COG5212	phosphodiesterase
ACZ76_15180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACZ76_15185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACZ76_15190	COG1984	allophanate hydrolase subunit 2
ACZ76_15195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACZ76_15220	COG2009	succinate dehydrogenase
ACZ76_15225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ACZ76_15230	COG1053	succinate dehydrogenase
ACZ76_15235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACZ76_15240	COG0567	Dehydrogenase, E1 component
ACZ76_15245	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACZ76_15250	COG0045	succinate-CoA ligase (ADP-forming) activity
ACZ76_15255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACZ76_15260	COG0737	Belongs to the 5'-nucleotidase family
ACZ76_15265	COG1271	oxidase subunit
ACZ76_15270	COG1294	oxidase, subunit
ACZ76_15275	COG4890	Cyd operon protein YbgT
ACZ76_15280	COG3790	cyd operon protein YbgE
ACZ76_15285	COG0824	Thioesterase
ACZ76_15290	COG0811	peptide transport
ACZ76_15295	COG0848	biopolymer transport protein
ACZ76_15300	COG3064	Membrane
ACZ76_15300	COG3064	Membrane
ACZ76_15305	COG0823	Involved in the tonB-independent uptake of proteins
ACZ76_15310	COG2885	chlorophyll binding
ACZ76_15315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ACZ76_15350	COG1230	cation diffusion facilitator family transporter
ACZ76_15355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACZ76_15360	COG0588	phosphoglycerate mutase activity
ACZ76_15370	COG2017	converts alpha-aldose to the beta-anomer
ACZ76_15375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ACZ76_15380	COG1085	galactose-1-phosphate uridylyltransferase
ACZ76_15385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACZ76_15395	COG1119	ATPase activity
ACZ76_15400	COG2005	Transcriptional regulator
ACZ76_15400	COG3585	molybdate ion transport
ACZ76_15410	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACZ76_15415	COG4149	molybdate abc transporter
ACZ76_15425	COG3037	sugar-specific permease SgaT UlaA
ACZ76_15435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACZ76_15440	COG1609	Transcriptional regulator
ACZ76_15445	COG0280	phosphate acetyltransferase
ACZ76_15445	COG0857	belongs to the CobB CobQ family
ACZ76_15455	COG3092	negative regulation of chromosome organization
ACZ76_15460	COG3013	Belongs to the UPF0304 family
ACZ76_15465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACZ76_15475	COG0490	domain, Protein
ACZ76_15475	COG0471	metal ion transport
ACZ76_15480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ACZ76_15485	COG0436	Aminotransferase
ACZ76_15490	COG0583	DNA-binding transcription factor activity
ACZ76_15495	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACZ76_15500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACZ76_15505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACZ76_15505	COG0649	NAD binding
ACZ76_15510	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACZ76_15520	COG1034	ATP synthesis coupled electron transport
ACZ76_15525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACZ76_15530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACZ76_15535	COG0839	Belongs to the complex I subunit 6 family
ACZ76_15540	COG0713	ATP synthesis coupled electron transport
ACZ76_15545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACZ76_15550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACZ76_15555	COG1007	ATP synthesis coupled electron transport
ACZ76_15585	COG3265	gluconokinase activity
ACZ76_15590	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_15595	COG1609	Transcriptional regulator
ACZ76_15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACZ76_15610	COG4702	Belongs to the UPF0303 family
ACZ76_15615	COG0129	dihydroxy-acid dehydratase activity
ACZ76_15620	COG4575	ribosome binding
ACZ76_15630	COG1169	isochorismate synthase
ACZ76_15635	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ACZ76_15645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ACZ76_15650	COG1441	menaquinone biosynthetic process
ACZ76_15675	COG0814	amino acid
ACZ76_15710	COG4574	serine-type endopeptidase inhibitor activity
ACZ76_15715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACZ76_15725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACZ76_15730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACZ76_15740	COG2205	protein histidine kinase activity
ACZ76_15740	COG0784	Response regulator, receiver
ACZ76_15750	COG0642	Histidine kinase
ACZ76_15750	COG2198	Histidine kinase
ACZ76_15755	COG2223	nitrite transmembrane transporter activity
ACZ76_15770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACZ76_15785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACZ76_15840	COG4386	tail sheath protein
ACZ76_15880	COG3299	homolog of phage Mu protein gp47
ACZ76_15900	COG1737	Transcriptional regulator
ACZ76_15905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_15905	COG1263	PTS System
ACZ76_15905	COG2190	(PTS) system
ACZ76_15910	COG2723	6-phospho-beta-galactosidase activity
ACZ76_15925	COG3423	Transcriptional regulator
ACZ76_15955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACZ76_15975	COG3082	Protein of unknown function (DUF1414)
ACZ76_15980	COG3081	Nucleoid-associated protein
ACZ76_15990	COG1061	Type III restriction enzyme res subunit
ACZ76_15995	COG1187	pseudouridine synthase activity
ACZ76_16000	COG2814	Major facilitator Superfamily
ACZ76_16010	COG4172	Belongs to the ABC transporter superfamily
ACZ76_16015	COG4239	(ABC) transporter, permease
ACZ76_16020	COG4174	ABC transporter (Permease)
ACZ76_16025	COG4166	transmembrane transport
ACZ76_16030	COG2200	EAL domain
ACZ76_16035	COG0791	NLP P60 protein
ACZ76_16040	COG0671	phosphoesterase, PA-phosphatase related
ACZ76_16045	COG0523	cobalamin synthesis protein
ACZ76_16055	COG2186	Transcriptional regulator
ACZ76_16060	COG0246	Mannitol dehydrogenase
ACZ76_16065	COG1312	Catalyzes the dehydration of D-mannonate
ACZ76_16070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACZ76_16085	COG0243	molybdopterin cofactor binding
ACZ76_16090	COG3005	denitrification pathway
ACZ76_16105	COG1105	Belongs to the carbohydrate kinase PfkB family
ACZ76_16110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACZ76_16110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACZ76_16110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ACZ76_16115	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACZ76_16120	COG2855	membrane
ACZ76_16135	COG0583	DNA-binding transcription factor activity
ACZ76_16140	COG0833	amino acid
ACZ76_16145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACZ76_16155	COG4771	TonB-dependent receptor
ACZ76_16160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACZ76_16180	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ACZ76_16185	COG0625	glutathione transferase activity
ACZ76_16210	COG2011	ABC-type metal ion transport system permease component
ACZ76_16220	COG0626	cystathionine gamma-synthase activity
ACZ76_16230	COG1686	Belongs to the peptidase S11 family
ACZ76_16235	COG1760	l-serine dehydratase
ACZ76_16240	COG0814	amino acid
ACZ76_16245	COG1349	DNA-binding transcription factor activity
ACZ76_16250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ACZ76_16255	COG0671	phosphoesterase, PA-phosphatase related
ACZ76_16265	COG2985	domain, Protein
ACZ76_16265	COG0569	domain protein
ACZ76_16270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACZ76_16285	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACZ76_16290	COG3842	ATPase activity
ACZ76_16295	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACZ76_16300	COG1177	transmembrane transport
ACZ76_16315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_16320	COG4160	amino acid transport
ACZ76_16325	COG4215	(ABC) transporter
ACZ76_16330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACZ76_16335	COG1126	abc transporter atp-binding protein
ACZ76_16340	COG1605	Chorismate mutase
ACZ76_16350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACZ76_16355	COG0702	epimerase
ACZ76_16360	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ACZ76_16370	COG0028	Belongs to the TPP enzyme family
ACZ76_16375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACZ76_16380	COG1151	hydroxylamine reductase activity
ACZ76_16385	COG2431	L-lysine efflux transmembrane transporter activity
ACZ76_16390	COG3593	DNA synthesis involved in DNA repair
ACZ76_16395	COG2990	Protein conserved in bacteria
ACZ76_16400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACZ76_16410	COG1278	Cold shock
ACZ76_16415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACZ76_16420	COG0542	response to heat
ACZ76_16425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACZ76_16430	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACZ76_16435	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ACZ76_16445	COG0492	ferredoxin-NADP+ reductase activity
ACZ76_16455	COG1674	ftsk spoiiie
ACZ76_16455	COG3107	peptidoglycan biosynthetic process
ACZ76_16460	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACZ76_16465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACZ76_16470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACZ76_16475	COG2814	Major facilitator Superfamily
ACZ76_16480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ACZ76_16485	COG1882	Formate acetyltransferase
ACZ76_16490	COG2116	formate transmembrane transporter activity
ACZ76_16495	COG1944	ATP diphosphatase activity
ACZ76_16500	COG0252	asparaginase activity
ACZ76_16505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACZ76_16510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACZ76_16515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACZ76_16520	COG0539	negative regulation of cytoplasmic translation
ACZ76_16525	COG0776	regulation of translation
ACZ76_16530	COG2333	competence protein COMEC
ACZ76_16530	COG0658	competence protein
ACZ76_16545	COG5383	Protein conserved in bacteria
ACZ76_16550	COG1278	Cold shock
ACZ76_16555	COG2835	tetraacyldisaccharide 4'-kinase activity
ACZ76_16565	COG3173	Aminoglycoside phosphotransferase
ACZ76_16570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACZ76_16575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACZ76_16580	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ACZ76_16585	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ACZ76_16595	COG2989	Protein conserved in bacteria
ACZ76_16600	COG3108	Peptidase M15
ACZ76_16605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACZ76_16610	COG2200	EAL domain
ACZ76_16615	COG1448	Aminotransferase
ACZ76_16625	COG0017	Asparaginyl-tRNA synthetase
ACZ76_16630	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACZ76_16635	COG0308	aminopeptidase N
ACZ76_16640	COG0167	dihydroorotate dehydrogenase activity
ACZ76_16650	COG3217	Mosc domain protein beta barrel domain protein
ACZ76_16650	COG0633	Ferredoxin
ACZ76_16655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACZ76_16655	COG0116	Belongs to the methyltransferase superfamily
ACZ76_16660	COG0488	(ABC) transporter
ACZ76_16665	COG2995	paraquat-inducible protein a
ACZ76_16670	COG3008	intermembrane lipid transfer
ACZ76_16670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACZ76_16675	COG3009	Protein conserved in bacteria
ACZ76_16680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACZ76_16690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACZ76_16695	COG1067	ATP-dependent peptidase activity
ACZ76_16700	COG3120	sequence-specific DNA binding
ACZ76_16705	COG2885	chlorophyll binding
ACZ76_16705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ACZ76_16710	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ACZ76_16715	COG3070	regulator of competence-specific genes
ACZ76_16720	COG1289	transmembrane transporter activity
ACZ76_16725	COG3304	Inner membrane component domain
ACZ76_16730	COG0210	DNA helicase
ACZ76_16735	COG1803	Methylglyoxal synthase
ACZ76_16740	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
ACZ76_16745	COG1832	CoA-binding protein
ACZ76_16750	COG3785	DNA binding
ACZ76_16755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACZ76_16775	COG1254	Belongs to the acylphosphatase family
ACZ76_16780	COG2920	part of a sulfur-relay system
ACZ76_16820	COG2375	cellular response to nickel ion
ACZ76_16830	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ACZ76_16835	COG0437	4 iron, 4 sulfur cluster binding
ACZ76_16840	COG3301	Polysulphide reductase, NrfD
ACZ76_16845	COG1138	Cytochrome C-type biogenesis protein
ACZ76_16850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACZ76_16855	COG3088	subunit of a heme lyase
ACZ76_16860	COG3088	subunit of a heme lyase
ACZ76_16860	COG4235	cytochrome complex assembly
ACZ76_16865	COG2771	luxR family
ACZ76_16870	COG3916	Acyl-homoserine-lactone synthase
ACZ76_16880	COG3263	regulation of cellular component size
ACZ76_16895	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ACZ76_16900	COG2943	transferase activity, transferring hexosyl groups
ACZ76_16905	COG5645	(Lipo)protein
ACZ76_16915	COG3104	oligopeptide transport
ACZ76_16920	COG2814	Major facilitator Superfamily
ACZ76_16925	COG2259	Doxx family
ACZ76_16930	COG1560	Kdo2-lipid A biosynthetic process
ACZ76_16970	COG0628	permease
ACZ76_16995	COG0418	dihydroorotase activity
ACZ76_17000	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ACZ76_17005	COG1530	ribonuclease E activity
ACZ76_17005	COG1530	ribonuclease E activity
ACZ76_17010	COG0564	pseudouridine synthase activity
ACZ76_17020	COG1399	metal-binding, possibly nucleic acid-binding protein
ACZ76_17025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACZ76_17030	COG0416	fatty acid biosynthetic process
ACZ76_17045	COG1028	Short-chain dehydrogenase reductase Sdr
ACZ76_17055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACZ76_17060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACZ76_17065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACZ76_17070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACZ76_17075	COG0470	DNA polymerase III
ACZ76_17080	COG0084	hydrolase, TatD family'
ACZ76_17085	COG1263	PTS System
ACZ76_17085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACZ76_17220	COG4695	Portal protein
ACZ76_17285	COG4974	Belongs to the 'phage' integrase family
ACZ76_17315	COG0641	radical SAM
ACZ76_17320	COG4533	DNA binding
ACZ76_17325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACZ76_17330	COG0537	adenosine 5'-monophosphoramidase activity
ACZ76_17335	COG5633	Lipoprotein
ACZ76_17340	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ACZ76_17345	COG0510	thiamine kinase activity
ACZ76_17355	COG3150	esterase
ACZ76_17360	COG1252	NADH dehydrogenase
ACZ76_17365	COG3134	Outer membrane lipoprotein
ACZ76_17370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACZ76_17375	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACZ76_17385	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACZ76_17390	COG1940	carbohydrate kinase activity
ACZ76_17395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACZ76_17405	COG2850	peptidyl-arginine hydroxylation
ACZ76_17415	COG0745	RESPONSE REGULATOR receiver
ACZ76_17425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACZ76_17430	COG2915	High frequency lysogenization protein hflD homolog
ACZ76_17435	COG0482	sulfurtransferase activity
ACZ76_17445	COG1187	pseudouridine synthase activity
ACZ76_17450	COG0538	isocitrate dehydrogenase activity
ACZ76_17460	COG0561	phosphatase activity
ACZ76_17465	COG2223	nitrite transmembrane transporter activity
ACZ76_17485	COG3493	citrate carrier protein
ACZ76_17490	COG4565	transcriptional regulatory protein
ACZ76_17495	COG3290	protein histidine kinase activity
ACZ76_17500	COG2066	Belongs to the glutaminase family
ACZ76_17515	COG1609	Transcriptional regulator
ACZ76_17520	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ACZ76_17525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ACZ76_17530	COG2723	6-phospho-beta-galactosidase activity
ACZ76_17535	COG1447	Phosphotransferase system cellobiose-specific component IIA
ACZ76_17545	COG0672	)-iron permease
ACZ76_17560	COG1136	(ABC) transporter
ACZ76_17560	COG0577	efflux transmembrane transporter activity
ACZ76_17570	COG1136	(ABC) transporter
ACZ76_17570	COG0577	efflux transmembrane transporter activity
ACZ76_17600	COG0006	proline dipeptidase activity
ACZ76_17605	COG0457	Tetratricopeptide repeat
ACZ76_17610	COG1649	PFAM Uncharacterised BCR, COG1649
ACZ76_17610	COG0726	polysaccharide deacetylase
ACZ76_17615	COG1215	transferase activity, transferring glycosyl groups
ACZ76_17620	COG3658	cytochrome
ACZ76_17630	COG1702	phosphate starvation-inducible protein PhoH
ACZ76_17635	COG0387	Pfam Sodium calcium exchanger
ACZ76_17645	COG0583	DNA-binding transcription factor activity
ACZ76_17650	COG3850	Histidine kinase
ACZ76_17655	COG1294	oxidase, subunit
ACZ76_17660	COG1271	oxidase subunit
ACZ76_17665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACZ76_17670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACZ76_17675	COG3138	arginine N-succinyltransferase
ACZ76_17685	COG3724	N-succinylarginine dihydrolase activity
ACZ76_17690	COG2988	succinylglutamate desuccinylase activity
ACZ76_17705	COG1228	amidohydrolase
ACZ76_17730	COG1129	ABC transporter
ACZ76_17735	COG4211	Belongs to the binding-protein-dependent transport system permease family
ACZ76_17740	COG3443	Belongs to the bacterial solute-binding protein 9 family
ACZ76_17750	COG4942	peptidase
ACZ76_17760	COG0738	Major facilitator superfamily
ACZ76_17765	COG0583	DNA-binding transcription factor activity
ACZ76_17770	COG2271	Major facilitator Superfamily
ACZ76_17785	COG4670	ketone body catabolic process
ACZ76_17790	COG1960	acyl-CoA dehydrogenase activity
ACZ76_17795	COG2207	Transcriptional regulator
ACZ76_17795	COG1917	Cupin 2, conserved barrel domain protein
ACZ76_17800	COG2086	electron transfer activity
ACZ76_17805	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACZ76_17810	COG0644	oxidoreductase
ACZ76_17815	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACZ76_17820	COG0318	PFAM AMP-dependent synthetase and ligase
ACZ76_17830	COG1472	Belongs to the glycosyl hydrolase 3 family
ACZ76_17855	COG2197	response regulator
ACZ76_17860	COG0012	GTP binding
ACZ76_17870	COG0193	aminoacyl-tRNA hydrolase activity