locus-tag	class	description
CH48_1	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH48_100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH48_1000	COG3022	response to hydroperoxide
CH48_1003	COG0083	homoserine kinase activity
CH48_1005	COG0745	RESPONSE REGULATOR receiver
CH48_1006	COG3045	CreA protein
CH48_1007	COG0406	alpha-ribazole phosphatase activity
CH48_1008	COG3708	Transcriptional regulator
CH48_1008	COG2207	Transcriptional regulator
CH48_1009	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH48_101	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH48_1010	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH48_1011	COG0741	lytic transglycosylase activity
CH48_1012	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH48_1014	COG2199	diguanylate cyclase activity
CH48_1015	COG2885	chlorophyll binding
CH48_1016	COG0488	(ABC) transporter
CH48_102	COG3173	Aminoglycoside phosphotransferase
CH48_1020	COG0604	alcohol dehydrogenase
CH48_1022	COG0560	Phosphoserine phosphatase
CH48_1023	COG3726	membrane protein affecting hemolysin expression
CH48_1024	COG0813	purine-nucleoside phosphorylase activity
CH48_1025	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH48_1026	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH48_1027	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH48_1028	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH48_1029	COG0084	hydrolase, TatD family'
CH48_103	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CH48_1030	COG4667	esterase of the alpha-beta hydrolase superfamily
CH48_1032	COG2823	Periplasmic or secreted lipoprotein
CH48_1033	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH48_1034	COG0456	acetyltransferase
CH48_1035	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH48_1036	COG2813	Specifically methylates the guanine in position
CH48_1037	COG0667	Aldo Keto reductase
CH48_1038	COG0583	DNA-binding transcription factor activity
CH48_104	COG2835	tetraacyldisaccharide 4'-kinase activity
CH48_1042	COG3706	GGDEF domain
CH48_1043	COG4772	TonB-dependent receptor
CH48_105	COG1278	Cold shock
CH48_1050	COG3284	Transcriptional regulator
CH48_1056	COG2192	nodulation
CH48_1058	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH48_1058	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_1058	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH48_1059	COG1461	Dihydroxyacetone kinase
CH48_106	COG1278	Cold shock
CH48_1060	COG2376	Dihydroxyacetone kinase
CH48_1062	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_1063	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_1064	COG2235	arginine
CH48_1067	COG0859	PFAM glycosyl transferase family 9
CH48_1068	COG1070	Carbohydrate kinase
CH48_1069	COG2390	Transcriptional regulator
CH48_107	COG5383	Protein conserved in bacteria
CH48_1070	COG1129	ABC transporter
CH48_1071	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_1072	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_1073	COG1879	ABC-type sugar transport system periplasmic component
CH48_1074	COG1830	Aldolase
CH48_1075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH48_1078	COG3328	transposase activity
CH48_108	COG1663	tetraacyldisaccharide 4'-kinase activity
CH48_1085	COG0454	-acetyltransferase
CH48_1086	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH48_1086	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CH48_1096	COG0795	lipopolysaccharide-transporting ATPase activity
CH48_1097	COG0795	lipopolysaccharide-transporting ATPase activity
CH48_1098	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH48_1099	COG2927	DNA polymerase III (CHI subunit)
CH48_11	COG0564	pseudouridine synthase activity
CH48_110	COG2333	competence protein COMEC
CH48_110	COG0658	competence protein
CH48_1103	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH48_1105	COG2731	YhcH YjgK YiaL family protein
CH48_1107	COG0601	transmembrane transport
CH48_1109	COG0444	Belongs to the ABC transporter superfamily
CH48_111	COG0776	regulation of translation
CH48_1110	COG4608	Belongs to the ABC transporter superfamily
CH48_1115	COG2188	Transcriptional regulator
CH48_1116	COG3624	Phosphonate C-P lyase system protein PhnG
CH48_1117	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH48_1118	COG3626	phosphonate metabolism
CH48_1119	COG3627	carbon phosphorus lyase activity
CH48_1120	COG4107	phosphonate C-P lyase system protein PhnK
CH48_1121	COG4778	phosphonate C-P lyase system protein PhnL
CH48_1122	COG3454	Phosphonate metabolism
CH48_1123	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH48_1124	COG0702	epimerase
CH48_1125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH48_1128	COG3787	Belongs to the UPF0306 family
CH48_113	COG0539	negative regulation of cytoplasmic translation
CH48_1130	COG3842	ATPase activity
CH48_1131	COG0395	ABC-type sugar transport system, permease component
CH48_1133	COG1653	transport
CH48_1136	COG1982	Orn Lys Arg decarboxylase major
CH48_1137	COG0531	amino acid
CH48_1138	COG3153	acetyltransferase
CH48_1139	COG2827	Endonuclease containing a URI domain
CH48_114	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH48_1143	COG3681	Belongs to the UPF0597 family
CH48_1144	COG0814	amino acid
CH48_1146	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH48_1148	COG0513	Belongs to the DEAD box helicase family
CH48_115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH48_1150	COG1185	polyribonucleotide nucleotidyltransferase activity
CH48_1151	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CH48_1152	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH48_1153	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH48_1154	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH48_1155	COG0195	Participates in both transcription termination and antitermination
CH48_1156	COG0779	Required for maturation of 30S ribosomal subunits
CH48_1159	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH48_116	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH48_1160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH48_1161	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH48_1162	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH48_1163	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH48_1164	COG1534	Rna-binding protein
CH48_1165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH48_1166	COG2027	D-alanyl-D-alanine carboxypeptidase
CH48_1167	COG0745	RESPONSE REGULATOR receiver
CH48_1168	COG0642	Histidine kinase
CH48_1169	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH48_117	COG2323	membrane
CH48_1170	COG0697	spore germination
CH48_1171	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CH48_1172	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CH48_1173	COG0142	geranyltranstransferase activity
CH48_1175	COG3423	Transcriptional regulator
CH48_1176	COG0039	L-malate dehydrogenase activity
CH48_1177	COG1438	arginine binding
CH48_1179	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH48_118	COG0252	asparaginase activity
CH48_1182	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH48_1183	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH48_1185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH48_1188	COG2105	PFAM AIG2 family protein
CH48_119	COG1944	ATP diphosphatase activity
CH48_1192	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH48_1193	COG1253	flavin adenine dinucleotide binding
CH48_1195	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH48_1196	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH48_1197	COG0737	Belongs to the 5'-nucleotidase family
CH48_1199	COG0545	Peptidyl-prolyl cis-trans isomerase
CH48_12	COG1530	ribonuclease E activity
CH48_120	COG2116	formate transmembrane transporter activity
CH48_1200	COG3061	Opacity-associated protein A
CH48_1202	COG0359	binds to the 23S rRNA
CH48_1203	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH48_1204	COG0360	Binds together with S18 to 16S ribosomal RNA
CH48_1206	COG1073	alpha beta
CH48_1207	COG3650	response to hydrogen peroxide
CH48_1208	COG1960	acyl-CoA dehydrogenase activity
CH48_1209	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH48_121	COG1882	Formate acetyltransferase
CH48_1210	COG0557	exoribonuclease II activity
CH48_1211	COG1959	2 iron, 2 sulfur cluster binding
CH48_1212	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH48_1213	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH48_1214	COG0330	HflC and HflK could
CH48_1215	COG0330	HflC and HflK could
CH48_1216	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH48_1217	COG1923	regulation of RNA biosynthetic process
CH48_1218	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH48_1219	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH48_122	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH48_1220	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH48_1221	COG0802	atpase or kinase
CH48_1222	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH48_1222	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH48_1223	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH48_1226	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH48_1227	COG1162	GTPase activity
CH48_1228	COG0688	phosphatidylethanolamine metabolic process
CH48_1229	COG3264	Mechanosensitive ion channel
CH48_1229	COG1511	domain protein
CH48_123	COG2814	Major facilitator Superfamily
CH48_1230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH48_1231	COG1053	succinate dehydrogenase
CH48_1232	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH48_1233	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH48_1234	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH48_1236	COG2076	Multidrug Resistance protein
CH48_1238	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH48_1241	COG0459	protein refolding
CH48_1242	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH48_1245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH48_1247	COG4232	protein-disulfide reductase activity
CH48_1248	COG1929	Belongs to the glycerate kinase type-1 family
CH48_1249	COG1309	transcriptional regulator
CH48_125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH48_1251	COG1882	Formate acetyltransferase
CH48_1252	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH48_1253	COG0814	amino acid
CH48_1254	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH48_1256	COG3721	Heme iron utilization protein
CH48_126	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH48_1260	COG3720	iron ion transport
CH48_1261	COG4558	Periplasmic binding protein
CH48_1262	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_1263	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH48_1264	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_1266	COG4774	siderophore transport
CH48_1267	COG3264	Mechanosensitive ion channel
CH48_1267	COG1511	domain protein
CH48_1268	COG2161	toxin-antitoxin pair type II binding
CH48_1269	COG0612	Peptidase, M16
CH48_127	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH48_1270	COG4178	(ABC) transporter
CH48_1271	COG4771	TonB-dependent receptor
CH48_1272	COG3712	iron ion homeostasis
CH48_1275	COG0425	Belongs to the sulfur carrier protein TusA family
CH48_1276	COG2391	methyltransferase activity
CH48_128	COG3107	peptidoglycan biosynthetic process
CH48_128	COG1674	ftsk spoiiie
CH48_129	COG1522	sequence-specific DNA binding
CH48_13	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH48_1308	COG5002	protein histidine kinase activity
CH48_1308	COG2205	protein histidine kinase activity
CH48_1308	COG0784	Response regulator, receiver
CH48_1309	COG2197	response regulator
CH48_131	COG0492	ferredoxin-NADP+ reductase activity
CH48_1310	COG1301	dicarboxylic acid transport
CH48_1311	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH48_1312	COG3162	membrane
CH48_1313	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH48_1323	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH48_1324	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH48_1325	COG0009	L-threonylcarbamoyladenylate synthase
CH48_1326	COG0551	DNA topoisomerase type I activity
CH48_1328	COG0758	DNA mediated transformation
CH48_1329	COG0242	peptide deformylase activity
CH48_133	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH48_1330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH48_1331	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH48_1331	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH48_1332	COG0569	domain protein
CH48_1333	COG1970	mechanosensitive ion channel activity
CH48_1336	COG3036	rescue of stalled ribosome
CH48_1337	COG0789	Transcriptional regulator
CH48_1339	COG0203	ribosomal protein L17
CH48_134	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CH48_1340	COG0202	RNA polymerase activity
CH48_1341	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH48_1342	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH48_1343	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH48_1344	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH48_1345	COG0201	protein transport
CH48_1346	COG0200	Binds to the 23S rRNA
CH48_1347	COG1841	ribosomal large subunit assembly
CH48_1348	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH48_1349	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH48_135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH48_1350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH48_1352	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH48_1353	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CH48_1354	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH48_1355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH48_1356	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH48_1357	COG0255	Belongs to the universal ribosomal protein uL29 family
CH48_1358	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH48_1359	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH48_136	COG0542	response to heat
CH48_1360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH48_1361	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH48_1362	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH48_1363	COG0089	rRNA binding
CH48_1364	COG0088	Forms part of the polypeptide exit tunnel
CH48_1365	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH48_1366	COG0051	transcription antitermination factor activity, RNA binding
CH48_137	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH48_1370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH48_1372	COG0049	tRNA binding
CH48_1373	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH48_1374	COG2168	tRNA wobble position uridine thiolation
CH48_1375	COG2923	Belongs to the DsrF TusC family
CH48_1376	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH48_1377	COG2964	Protein conserved in bacteria
CH48_1378	COG0545	Peptidyl-prolyl cis-trans isomerase
CH48_1379	COG2900	Belongs to the SlyX family
CH48_1380	COG1047	Peptidyl-prolyl cis-trans
CH48_1381	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH48_1383	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH48_1384	COG0488	(ABC) transporter
CH48_1385	COG1216	Glycosyl transferase, family 2
CH48_1387	COG2175	clavaminate synthase activity
CH48_1388	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH48_139	COG1278	Cold shock
CH48_1390	COG4521	taurine ABC transporter
CH48_1393	COG0429	hydrolase of the alpha beta-hydrolase fold
CH48_1394	COG3089	Belongs to the UPF0270 family
CH48_1395	COG3954	Phosphoribulokinase
CH48_1396	COG1765	OsmC-like protein
CH48_1398	COG1289	transmembrane transporter activity
CH48_14	COG0418	dihydroorotase activity
CH48_1401	COG0433	COG0433 Predicted ATPase
CH48_1402	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH48_1404	COG1486	melibiose metabolic process
CH48_1406	COG0738	Major facilitator superfamily
CH48_1407	COG0402	S-adenosylhomocysteine deaminase activity
CH48_1408	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH48_1409	COG2146	nitrite reductase [NAD(P)H] activity
CH48_141	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_1411	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH48_1411	COG1648	precorrin-2 dehydrogenase activity
CH48_1412	COG0180	Tryptophanyl-tRNA synthetase
CH48_1414	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH48_1418	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH48_1419	COG4796	Type ii and iii secretion system protein
CH48_142	COG3593	DNA synthesis involved in DNA repair
CH48_1424	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH48_1425	COG0494	nUDIX hydrolase
CH48_1427	COG1011	Hydrolase
CH48_1428	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH48_143	COG2990	Protein conserved in bacteria
CH48_1430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH48_1433	COG0745	RESPONSE REGULATOR receiver
CH48_1434	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH48_1439	COG2183	response to ionizing radiation
CH48_144	COG2431	L-lysine efflux transmembrane transporter activity
CH48_1440	COG1918	ferrous iron import across plasma membrane
CH48_1441	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CH48_1444	COG0596	Alpha beta hydrolase
CH48_1446	COG0316	Belongs to the HesB IscA family
CH48_1446	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH48_1449	COG1640	4-alpha-glucanotransferase
CH48_145	COG1151	hydroxylamine reductase activity
CH48_1450	COG0058	SHG alpha-glucan phosphorylase activity
CH48_1452	COG0058	SHG alpha-glucan phosphorylase activity
CH48_1453	COG2909	trisaccharide binding
CH48_1456	COG0705	Rhomboid family
CH48_1457	COG1349	DNA-binding transcription factor activity
CH48_1459	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH48_146	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH48_1460	COG0058	SHG alpha-glucan phosphorylase activity
CH48_1461	COG0297	glycogen (starch) synthase activity
CH48_1463	COG1523	belongs to the glycosyl hydrolase 13 family
CH48_1464	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH48_1466	COG3275	phosphorelay sensor kinase activity
CH48_1469	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH48_147	COG0028	Belongs to the TPP enzyme family
CH48_1470	COG2095	MarC family integral membrane protein
CH48_1471	COG3265	gluconokinase activity
CH48_1472	COG2610	gluconate transmembrane transporter activity
CH48_1473	COG1609	Transcriptional regulator
CH48_1474	COG1741	Belongs to the pirin family
CH48_1475	COG1247	-acetyltransferase
CH48_1476	COG1082	Xylose isomerase domain protein TIM barrel
CH48_1477	COG0673	inositol 2-dehydrogenase activity
CH48_1479	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_1481	COG3718	enzyme involved in inositol metabolism
CH48_1483	COG2814	Major facilitator Superfamily
CH48_1484	COG0583	DNA-binding transcription factor activity
CH48_1486	COG0561	phosphatase activity
CH48_1488	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_1488	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_1489	COG0583	DNA-binding transcription factor activity
CH48_149	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH48_1490	COG1648	precorrin-2 dehydrogenase activity
CH48_1490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH48_1492	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH48_1494	COG4865	methylaspartate mutase activity
CH48_1495	COG3799	methylaspartate ammonia-lyase activity
CH48_1498	COG1301	dicarboxylic acid transport
CH48_1499	COG2081	HI0933 family
CH48_150	COG0702	epimerase
CH48_1500	COG0306	phosphate transporter
CH48_1502	COG0589	response to stress
CH48_1505	COG0742	ribosomal rna small subunit methyltransferase
CH48_1507	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH48_1508	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_151	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_1510	COG1295	ribonuclease BN
CH48_1511	COG2134	cdp-diacylglycerol pyrophosphatase
CH48_1512	COG2982	Protein involved in outer membrane biogenesis
CH48_1513	COG2200	EAL domain
CH48_1514	COG1942	4-Oxalocrotonate Tautomerase
CH48_1516	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_1517	COG0612	Peptidase, M16
CH48_1518	COG1301	dicarboxylic acid transport
CH48_1521	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH48_1522	COG2200	EAL domain
CH48_1522	COG2199	diguanylate cyclase activity
CH48_1525	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH48_1526	COG1215	transferase activity, transferring glycosyl groups
CH48_1527	COG1215	transferase activity, transferring glycosyl groups
CH48_1528	COG1192	Involved in chromosome partitioning
CH48_153	COG1126	abc transporter atp-binding protein
CH48_1532	COG2194	sulfuric ester hydrolase activity
CH48_1533	COG4608	Belongs to the ABC transporter superfamily
CH48_1534	COG0444	Belongs to the ABC transporter superfamily
CH48_1535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_1536	COG0601	transmembrane transport
CH48_1537	COG0747	negative chemotaxis
CH48_1539	COG1764	response to oxidative stress
CH48_154	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_1540	COG2194	sulfuric ester hydrolase activity
CH48_1541	COG2197	response regulator
CH48_1542	COG3851	Histidine kinase
CH48_1543	COG2271	Major facilitator Superfamily
CH48_1546	COG2831	hemolysin activation secretion protein
CH48_1547	COG3210	domain, Protein
CH48_1549	COG3328	transposase activity
CH48_155	COG4215	(ABC) transporter
CH48_1554	COG1609	Transcriptional regulator
CH48_1555	COG1940	carbohydrate kinase activity
CH48_1556	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH48_1557	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_1558	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_1559	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_156	COG4160	amino acid transport
CH48_1563	COG2723	6-phospho-beta-galactosidase activity
CH48_1564	COG1482	cell wall glycoprotein biosynthetic process
CH48_1568	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH48_1569	COG2986	histidine ammonia-lyase
CH48_157	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_1578	COG0582	viral genome integration into host DNA
CH48_158	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH48_1580	COG1609	Transcriptional regulator
CH48_1580	COG2207	Transcriptional regulator
CH48_1581	COG4214	carbohydrate transport
CH48_1583	COG4213	ABC transporter substrate-binding protein
CH48_1584	COG2115	Belongs to the xylose isomerase family
CH48_1585	COG1070	Carbohydrate kinase
CH48_1586	COG3121	Chaperone
CH48_1588	COG3274	enterobacterial common antigen metabolic process
CH48_1591	COG3276	selenocysteine insertion sequence binding
CH48_1592	COG1921	L-seryl-tRNASec selenium transferase activity
CH48_1593	COG3058	Necessary for formate dehydrogenase activity
CH48_1594	COG2864	formate dehydrogenase
CH48_1595	COG0437	4 iron, 4 sulfur cluster binding
CH48_1596	COG3383	formate dehydrogenase (NAD+) activity
CH48_1596	COG0243	molybdopterin cofactor binding
CH48_1597	COG0243	molybdopterin cofactor binding
CH48_1597	COG3383	formate dehydrogenase (NAD+) activity
CH48_1598	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH48_1599	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH48_160	COG1177	transmembrane transport
CH48_1600	COG0840	transmembrane signaling receptor activity
CH48_1601	COG2258	MOSC domain
CH48_1605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_1606	COG3722	fumarate hydratase activity
CH48_1608	COG0246	Mannitol dehydrogenase
CH48_1609	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_1609	COG2213	PTS system mannitol-specific
CH48_161	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH48_1611	COG0751	glycine-tRNA ligase activity
CH48_1612	COG0752	glycyl-tRNA synthetase alpha subunit
CH48_1613	COG2818	Glycosylase
CH48_1614	COG0456	acetyltransferase
CH48_162	COG3842	ATPase activity
CH48_1620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH48_1621	COG0366	Alpha amylase catalytic
CH48_1622	COG3977	Valine--pyruvate aminotransferase
CH48_1623	COG2985	domain, Protein
CH48_1623	COG0569	domain protein
CH48_1627	COG5645	(Lipo)protein
CH48_1628	COG0823	Involved in the tonB-independent uptake of proteins
CH48_163	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH48_1630	COG2423	ornithine cyclodeaminase activity
CH48_1631	COG0561	phosphatase activity
CH48_1632	COG0187	DNA topoisomerase II activity
CH48_1633	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH48_1634	COG0592	DNA-directed DNA polymerase activity
CH48_1635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH48_1636	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH48_1637	COG0594	ribonuclease P activity
CH48_1639	COG0706	membrane insertase activity
CH48_1640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH48_1641	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH48_1644	COG2011	ABC-type metal ion transport system permease component
CH48_1645	COG0840	transmembrane signaling receptor activity
CH48_1646	COG0431	NADPH-dependent FMN reductase
CH48_1648	COG4566	intracellular signal transduction
CH48_1650	COG2252	PERMEase
CH48_1651	COG0765	amino acid transport
CH48_1652	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_1653	COG0765	amino acid transport
CH48_1654	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_1656	COG0704	Plays a role in the regulation of phosphate uptake
CH48_1658	COG0581	inorganic phosphate transmembrane transporter activity
CH48_1659	COG0573	inorganic phosphate transmembrane transporter activity
CH48_166	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH48_1660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH48_1662	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH48_1663	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH48_1664	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH48_1665	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH48_1666	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CH48_1667	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH48_1668	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH48_1669	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH48_167	COG2985	domain, Protein
CH48_167	COG0569	domain protein
CH48_1671	COG0356	it plays a direct role in the translocation of protons across the membrane
CH48_1672	COG3312	ion transport
CH48_1673	COG0357	Ribosomal RNA small subunit methyltransferase G
CH48_1674	COG0445	tRNA wobble uridine modification
CH48_1675	COG0716	FMN binding
CH48_1676	COG1522	sequence-specific DNA binding
CH48_1677	COG2502	aspartate--ammonia ligase
CH48_1679	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH48_1680	COG0714	Associated with various cellular activities
CH48_1681	COG3158	transport of potassium into the cell
CH48_1682	COG1869	D-ribose catabolic process
CH48_1684	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_1685	COG1879	ABC-type sugar transport system periplasmic component
CH48_1686	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_1688	COG1609	Transcriptional regulator
CH48_169	COG0671	phosphoesterase, PA-phosphatase related
CH48_1690	COG2186	Transcriptional regulator
CH48_1698	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH48_170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH48_1700	COG3084	Protein conserved in bacteria
CH48_1701	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH48_1702	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH48_1703	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH48_1703	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH48_1704	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH48_1705	COG3078	GTPase activator activity
CH48_1706	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH48_1708	COG3852	Histidine kinase
CH48_171	COG1349	DNA-binding transcription factor activity
CH48_1710	COG0174	glutamine synthetase
CH48_1712	COG1011	Hydrolase
CH48_1713	COG1295	ribonuclease BN
CH48_1714	COG1490	D-aminoacyl-tRNA deacylase activity
CH48_1715	COG0456	acetyltransferase
CH48_1716	COG3423	Transcriptional regulator
CH48_1719	COG2982	Protein involved in outer membrane biogenesis
CH48_172	COG0814	amino acid
CH48_1721	COG2233	PERMEase
CH48_1722	COG0786	glutamate:sodium symporter activity
CH48_1724	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH48_1725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH48_1726	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH48_1727	COG1758	RNA polymerase activity
CH48_173	COG1760	l-serine dehydratase
CH48_1731	COG2860	membrane
CH48_1733	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH48_1734	COG1024	Enoyl-CoA hydratase
CH48_1735	COG5001	Diguanylate cyclase
CH48_1738	COG1561	YicC-like family, N-terminal region
CH48_1739	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CH48_1740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH48_1741	COG1309	transcriptional regulator
CH48_1742	COG0756	dUTP diphosphatase activity
CH48_1743	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH48_1744	COG2003	Belongs to the UPF0758 family
CH48_1745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH48_1746	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH48_1747	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH48_1748	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH48_1750	COG1519	Transferase
CH48_1751	COG0859	PFAM glycosyl transferase family 9
CH48_1752	COG0859	PFAM glycosyl transferase family 9
CH48_1753	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_1754	COG0156	8-amino-7-oxononanoate synthase activity
CH48_1755	COG1063	alcohol dehydrogenase
CH48_1758	COG2861	carbohydrate metabolic process
CH48_1759	COG4942	peptidase
CH48_176	COG1686	Belongs to the peptidase S11 family
CH48_1760	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH48_1761	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH48_1762	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH48_1763	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH48_1764	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH48_1765	COG1045	serine acetyltransferase
CH48_1766	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH48_1767	COG2169	Transcriptional regulator
CH48_1767	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH48_1768	COG2205	protein histidine kinase activity
CH48_1769	COG0745	RESPONSE REGULATOR receiver
CH48_1770	COG3678	ATP-independent chaperone mediated protein folding
CH48_1771	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH48_1773	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH48_1775	COG0149	triose-phosphate isomerase activity
CH48_1777	COG3152	Membrane
CH48_178	COG0626	cystathionine gamma-synthase activity
CH48_1781	COG2814	Major facilitator Superfamily
CH48_1782	COG1494	fructose-1,6-bisphosphatase
CH48_1784	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH48_1785	COG3074	FtsZ-dependent cytokinesis
CH48_1786	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH48_1787	COG1575	Belongs to the MenA family. Type 1 subfamily
CH48_1788	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH48_1789	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH48_179	COG2011	ABC-type metal ion transport system permease component
CH48_1790	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH48_1791	COG1609	Transcriptional regulator
CH48_1792	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH48_1793	COG0254	rRNA binding
CH48_1794	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH48_1795	COG0626	cystathionine gamma-synthase activity
CH48_1796	COG0527	aspartate kinase activity
CH48_1796	COG0460	homoserine dehydrogenase
CH48_1798	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH48_1800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH48_1801	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH48_1802	COG0165	Argininosuccinate lyase
CH48_1803	COG1629	transport
CH48_1810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_1811	COG0678	peroxiredoxin activity
CH48_1811	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH48_1812	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_1814	COG1309	transcriptional regulator
CH48_1817	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH48_1819	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH48_1828	COG1879	ABC-type sugar transport system periplasmic component
CH48_1829	COG1129	ABC transporter
CH48_1830	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_1831	COG0583	DNA-binding transcription factor activity
CH48_1832	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_1833	COG3085	chromosome segregation
CH48_1836	COG3978	acetolactate synthase activity
CH48_1837	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH48_1838	COG0129	dihydroxy-acid dehydratase activity
CH48_1842	COG0583	DNA-binding transcription factor activity
CH48_1844	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH48_1849	COG3121	Chaperone
CH48_185	COG0625	glutathione transferase activity
CH48_1852	COG3121	Chaperone
CH48_1854	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH48_1857	COG0248	Ppx GppA phosphatase
CH48_1859	COG3118	belongs to the thioredoxin family
CH48_186	COG4771	TonB-dependent receptor
CH48_1860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH48_1862	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH48_1863	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH48_1864	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH48_1865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH48_1866	COG1088	dTDP-glucose 4,6-dehydratase activity
CH48_1867	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH48_1868	COG0456	acetyltransferase
CH48_1869	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH48_1870	COG2244	polysaccharide biosynthetic process
CH48_1871	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH48_1874	COG1113	amino acid transport
CH48_188	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_1881	COG3071	HemY protein
CH48_1882	COG2959	enzyme of heme biosynthesis
CH48_1883	COG1587	Uroporphyrinogen-III synthase
CH48_1884	COG0181	hydroxymethylbilane synthase activity
CH48_1885	COG3072	Adenylate cyclase
CH48_1886	COG1965	Belongs to the frataxin family
CH48_1887	COG5567	small periplasmic lipoprotein
CH48_1888	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH48_1889	COG3159	Protein conserved in bacteria
CH48_189	COG0833	amino acid
CH48_1890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH48_1891	COG1011	Hydrolase
CH48_1892	COG0210	DNA helicase
CH48_1894	COG5441	Belongs to the UPF0261 family
CH48_1895	COG5564	TIM-barrel signal transduction protein
CH48_1896	COG0598	Magnesium transport protein CorA
CH48_1898	COG2050	protein possibly involved in aromatic compounds catabolism
CH48_1899	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH48_19	COG0628	permease
CH48_190	COG0583	DNA-binding transcription factor activity
CH48_1900	COG0514	ATP-dependent DNA helicase (RecQ)
CH48_1901	COG1280	lysine exporter protein (LysE YggA)
CH48_1902	COG1280	lysine exporter protein (LysE YggA)
CH48_1903	COG2267	carboxylic ester hydrolase activity
CH48_1904	COG0561	phosphatase activity
CH48_1905	COG0584	glycerophosphoryl diester phosphodiesterase
CH48_1906	COG2271	Major facilitator Superfamily
CH48_1907	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH48_1908	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH48_1909	COG0247	lactate metabolic process
CH48_1911	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH48_1912	COG0425	Belongs to the sulfur carrier protein TusA family
CH48_1913	COG2217	Heavy metal translocating P-type atpase
CH48_1915	COG3714	YhhN family
CH48_1918	COG3776	membrane
CH48_1919	COG0742	ribosomal rna small subunit methyltransferase
CH48_1920	COG0552	protein localization to endoplasmic reticulum
CH48_1921	COG2884	Cell division ATP-binding protein ftsE
CH48_1922	COG2177	Part of the ABC transporter FtsEX involved in
CH48_1927	COG0683	leucine binding
CH48_1928	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH48_1929	COG4177	L-phenylalanine transmembrane transporter activity
CH48_1930	COG0411	ABC transporter
CH48_1931	COG0410	ABC transporter
CH48_1938	COG1653	transport
CH48_1939	COG1175	transmembrane transport
CH48_194	COG2855	membrane
CH48_1940	COG0395	ABC-type sugar transport system, permease component
CH48_1941	COG3842	ATPase activity
CH48_1942	COG0584	glycerophosphoryl diester phosphodiesterase
CH48_1943	COG0679	Auxin Efflux Carrier
CH48_1944	COG0583	DNA-binding transcription factor activity
CH48_1946	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH48_1947	COG0412	Dienelactone hydrolase
CH48_1948	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH48_195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH48_1951	COG1966	Carbon starvation protein
CH48_1952	COG0586	Pfam SNARE associated Golgi protein
CH48_1953	COG1322	Protein conserved in bacteria
CH48_1954	COG2226	methyltransferase
CH48_1956	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH48_1957	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH48_1958	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH48_1959	COG0805	protein transport
CH48_1963	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH48_1965	COG0183	Belongs to the thiolase family
CH48_1966	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH48_1966	COG1024	Enoyl-CoA hydratase
CH48_1968	COG0006	proline dipeptidase activity
CH48_1969	COG1739	Uncharacterized protein family UPF0029
CH48_1970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH48_1980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH48_1980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH48_1981	COG1072	(Pantothenic acid kinase))
CH48_1987	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH48_1988	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH48_1989	COG0250	Participates in transcription elongation, termination and antitermination
CH48_1990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH48_1991	COG0081	regulation of translation
CH48_1992	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH48_1993	COG0222	ribosome binding
CH48_1994	COG0085	RNA polymerase activity
CH48_1995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH48_1998	COG2022	thiamine diphosphate biosynthetic process
CH48_1999	COG2104	thiamine diphosphate biosynthetic process
CH48_2	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH48_200	COG3710	Transcriptional regulator
CH48_2000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH48_2002	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH48_2003	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH48_2004	COG2816	NAD+ diphosphatase activity
CH48_2005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH48_2006	COG1515	deoxyribonuclease V activity
CH48_2007	COG3068	Protein conserved in bacteria
CH48_201	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH48_201	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH48_201	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH48_2010	COG0151	Belongs to the GarS family
CH48_2011	COG0138	bifunctional purine biosynthesis protein purh
CH48_202	COG1105	Belongs to the carbohydrate kinase PfkB family
CH48_2021	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH48_2022	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH48_2023	COG2224	Isocitrate lyase
CH48_2024	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH48_2025	COG1414	Transcriptional regulator
CH48_2030	COG0527	aspartate kinase activity
CH48_2031	COG0166	Belongs to the GPI family
CH48_2033	COG3833	ABC-type maltose transport systems, permease component
CH48_2034	COG1175	transmembrane transport
CH48_2035	COG2182	Extracellular solute-binding protein
CH48_2037	COG4580	involved in the transport of maltose and maltodextrins
CH48_2040	COG3161	chorismate lyase activity
CH48_2041	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CH48_2042	COG2937	Belongs to the GPAT DAPAT family
CH48_2043	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH48_2044	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH48_2045	COG3237	CsbD-like
CH48_2046	COG0735	belongs to the Fur family
CH48_2048	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH48_205	COG3005	denitrification pathway
CH48_2052	COG0305	Participates in initiation and elongation during chromosome replication
CH48_2053	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH48_2054	COG1448	Aminotransferase
CH48_2056	COG2315	Protein conserved in bacteria
CH48_2057	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH48_2059	COG3550	peptidyl-serine autophosphorylation
CH48_206	COG0243	molybdopterin cofactor binding
CH48_2062	COG2252	PERMEase
CH48_2063	COG0025	NhaP-type Na H and K H
CH48_2064	COG0583	DNA-binding transcription factor activity
CH48_2065	COG1380	Effector of murein hydrolase LrgA
CH48_2067	COG1126	abc transporter atp-binding protein
CH48_2068	COG0765	amino acid transport
CH48_2069	COG4597	amino acid ABC transporter
CH48_2070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_2072	COG1560	Kdo2-lipid A biosynthetic process
CH48_2073	COG0471	metal ion transport
CH48_2074	COG1278	Cold shock
CH48_2075	COG1278	Cold shock
CH48_2076	COG3133	Outer membrane lipoprotein
CH48_2077	COG3706	GGDEF domain
CH48_2077	COG0745	RESPONSE REGULATOR receiver
CH48_2078	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH48_2079	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH48_2080	COG2264	protein methyltransferase activity
CH48_2082	COG4145	pantothenate transmembrane transporter activity
CH48_2083	COG3924	membrane
CH48_2084	COG0439	Biotin carboxylase
CH48_2085	COG0511	ligase activity, forming carbon-carbon bonds
CH48_2086	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH48_2087	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH48_2089	COG0604	alcohol dehydrogenase
CH48_209	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH48_2091	COG2200	EAL domain
CH48_2091	COG2199	diguanylate cyclase activity
CH48_2092	COG1077	Cell shape determining protein MreB Mrl
CH48_2093	COG1792	Involved in formation and maintenance of cell shape
CH48_2094	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH48_2096	COG1530	ribonuclease E activity
CH48_2097	COG3164	Protein of unknown function
CH48_2098	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH48_2099	COG0312	modulator of DNA gyrase
CH48_210	COG1312	Catalyzes the dehydration of D-mannonate
CH48_211	COG0246	Mannitol dehydrogenase
CH48_2114	COG0583	DNA-binding transcription factor activity
CH48_2116	COG1566	PFAM secretion protein HlyD family protein
CH48_2117	COG1289	transmembrane transporter activity
CH48_212	COG2186	Transcriptional regulator
CH48_2120	COG2732	(Barnase) inhibitor
CH48_2121	COG3028	Belongs to the UPF0307 family
CH48_2122	COG0312	modulator of DNA gyrase
CH48_2124	COG3783	Cytochrome b(562)
CH48_2125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH48_2131	COG3964	amidohydrolase
CH48_2134	COG2706	6-phosphogluconolactonase activity
CH48_2135	COG3711	transcriptional antiterminator
CH48_2135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_2136	COG3093	addiction module antidote protein HigA
CH48_2138	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH48_214	COG0523	cobalamin synthesis protein
CH48_2141	COG1263	PTS System
CH48_2141	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_2142	COG0366	Alpha amylase catalytic
CH48_2146	COG2308	Evidence 4 Homologs of previously reported genes of
CH48_2148	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH48_2149	COG0540	Belongs to the ATCase OTCase family
CH48_215	COG0671	phosphoesterase, PA-phosphatase related
CH48_2151	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_2152	COG1660	Displays ATPase and GTPase activities
CH48_2153	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_2155	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH48_2156	COG1137	ATPase activity
CH48_2157	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH48_2158	COG3117	lipopolysaccharide transmembrane transporter activity
CH48_2159	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH48_216	COG0791	NLP P60 protein
CH48_2160	COG0517	IMP dehydrogenase activity
CH48_2160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH48_2161	COG0530	calcium, potassium:sodium antiporter activity
CH48_2162	COG1127	ABC transporter
CH48_2163	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH48_2164	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH48_2165	COG2854	intermembrane phospholipid transfer
CH48_2166	COG3113	response to antibiotic
CH48_2167	COG5007	Belongs to the BolA IbaG family
CH48_2168	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH48_2169	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH48_217	COG2200	EAL domain
CH48_2170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH48_2171	COG3105	Protein conserved in bacteria
CH48_2172	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH48_2173	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH48_2174	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH48_2175	COG0625	glutathione transferase activity
CH48_2176	COG2969	positive regulation of protein catabolic process
CH48_2178	COG0493	'glutamate synthase
CH48_2179	COG0067	glutamate synthase
CH48_2179	COG0070	glutamate synthase
CH48_2179	COG0069	glutamate synthase activity
CH48_218	COG4166	transmembrane transport
CH48_2180	COG1242	4 iron, 4 sulfur cluster binding
CH48_2181	COG2198	Histidine kinase
CH48_2181	COG5002	protein histidine kinase activity
CH48_2181	COG0784	Response regulator, receiver
CH48_2182	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH48_2183	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH48_2184	COG2823	Periplasmic or secreted lipoprotein
CH48_2185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH48_2186	COG0792	nuclease activity
CH48_2188	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH48_219	COG4174	ABC transporter (Permease)
CH48_2190	COG3121	Chaperone
CH48_2194	COG0667	Aldo Keto reductase
CH48_2195	COG1064	alcohol dehydrogenase
CH48_2196	COG1741	Belongs to the pirin family
CH48_2197	COG0583	DNA-binding transcription factor activity
CH48_2198	COG0435	Glutathione S-transferase
CH48_2199	COG2259	Doxx family
CH48_220	COG4239	(ABC) transporter, permease
CH48_2201	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH48_2202	COG4575	ribosome binding
CH48_2205	COG0586	Pfam SNARE associated Golgi protein
CH48_2208	COG2271	Major facilitator Superfamily
CH48_2209	COG1904	glucuronate isomerase
CH48_221	COG4172	Belongs to the ABC transporter superfamily
CH48_2210	COG0246	Mannitol dehydrogenase
CH48_2211	COG2721	sulfolactate sulfo-lyase activity
CH48_2213	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH48_2214	COG0861	Integral membrane protein TerC family
CH48_2215	COG0673	inositol 2-dehydrogenase activity
CH48_2216	COG1451	nucleotide metabolic process
CH48_2219	COG2813	Specifically methylates the guanine in position
CH48_2221	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH48_2221	COG1902	pentaerythritol trinitrate reductase activity
CH48_2223	COG3247	response to pH
CH48_2225	COG0076	glutamate decarboxylase activity
CH48_2226	COG0531	amino acid
CH48_2228	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_2228	COG1263	PTS System
CH48_2229	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH48_223	COG2814	Major facilitator Superfamily
CH48_2231	COG1472	Belongs to the glycosyl hydrolase 3 family
CH48_2233	COG3876	Protein conserved in bacteria
CH48_2236	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH48_2237	COG0358	DNA primase activity
CH48_2239	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH48_224	COG1187	pseudouridine synthase activity
CH48_2240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH48_2241	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH48_2242	COG1968	undecaprenyl-diphosphatase activity
CH48_2243	COG0617	tRNA 3'-terminal CCA addition
CH48_2244	COG4991	sh3 domain protein
CH48_2245	COG3025	triphosphatase activity
CH48_2246	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH48_2247	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH48_2247	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH48_2248	COG0531	amino acid
CH48_225	COG1061	Type III restriction enzyme res subunit
CH48_2250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH48_2251	COG3384	dioxygenase
CH48_2252	COG0754	glutathionylspermidine amidase activity
CH48_2253	COG5463	Belongs to the UPF0441 family
CH48_2254	COG1538	Outer membrane efflux protein
CH48_2255	COG0494	nUDIX hydrolase
CH48_2256	COG3151	Protein conserved in bacteria
CH48_2257	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH48_2258	COG3150	esterase
CH48_2259	COG0187	DNA topoisomerase II activity
CH48_226	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CH48_2261	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH48_2262	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH48_2263	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH48_2264	COG0204	Acyl-transferase
CH48_2265	COG2132	Multicopper oxidase
CH48_2267	COG0656	L-ascorbic acid biosynthetic process
CH48_2268	COG1979	alcohol dehydrogenase
CH48_2269	COG2207	Transcriptional regulator
CH48_227	COG3081	Nucleoid-associated protein
CH48_2270	COG0586	Pfam SNARE associated Golgi protein
CH48_2271	COG0626	cystathionine gamma-synthase activity
CH48_2272	COG0811	peptide transport
CH48_2273	COG0848	biopolymer transport protein
CH48_228	COG3082	Protein of unknown function (DUF1414)
CH48_2283	COG4964	Belongs to the GSP D family
CH48_2289	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_2297	COG1136	(ABC) transporter
CH48_2297	COG0577	efflux transmembrane transporter activity
CH48_2302	COG1120	ATPase activity
CH48_2303	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_2304	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_2305	COG4592	Periplasmic binding protein
CH48_2306	COG2271	Major facilitator Superfamily
CH48_2307	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_2308	COG0840	transmembrane signaling receptor activity
CH48_2311	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH48_2313	COG1987	bacterial-type flagellum assembly
CH48_2317	COG2204	response regulator
CH48_2318	COG1677	Flagellar hook-basal body complex protein FliE
CH48_2328	COG1815	bacterial-type flagellum-dependent cell motility
CH48_2329	COG1558	bacterial-type flagellum-dependent cell motility
CH48_233	COG3328	transposase activity
CH48_2330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH48_2331	COG1749	Flagellar hook protein flgE
CH48_2333	COG4786	Flagellar basal body rod
CH48_2335	COG1706	bacterial-type flagellum-dependent cell motility
CH48_2341	COG3710	Transcriptional regulator
CH48_2342	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH48_2343	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH48_2344	COG1516	flagellar protein fliS
CH48_2348	COG1191	sigma factor activity
CH48_2349	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH48_235	COG2963	transposase activity
CH48_2351	COG3133	Outer membrane lipoprotein
CH48_2353	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH48_2354	COG0437	4 iron, 4 sulfur cluster binding
CH48_2355	COG5557	Pfam Polysulphide reductase, NrfD
CH48_2356	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH48_2357	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH48_2358	COG1773	rubredoxin
CH48_2359	COG0375	protein maturation
CH48_236	COG2801	Transposase and inactivated derivatives
CH48_2360	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH48_2361	COG0298	carbon dioxide binding
CH48_2362	COG0409	Hydrogenase expression formation protein
CH48_2363	COG0309	Hydrogenase expression formation protein (HypE)
CH48_2364	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH48_2366	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH48_2368	COG5001	Diguanylate cyclase
CH48_2369	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_2372	COG0477	Major facilitator Superfamily
CH48_2375	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH48_2377	COG1609	Transcriptional regulator
CH48_2378	COG0477	Major facilitator Superfamily
CH48_2379	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_2381	COG0697	spore germination
CH48_2384	COG4607	ABC-type enterochelin transport system periplasmic component
CH48_2386	COG4605	iron ion homeostasis
CH48_2387	COG4604	ABC transporter, ATP-binding protein
CH48_2388	COG0024	Methionine aminopeptidase
CH48_239	COG3338	carbonate dehydratase activity
CH48_2393	COG1289	transmembrane transporter activity
CH48_2395	COG1982	Orn Lys Arg decarboxylase major
CH48_2396	COG0531	amino acid
CH48_240	COG2723	6-phospho-beta-galactosidase activity
CH48_2406	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH48_2408	COG1982	Orn Lys Arg decarboxylase major
CH48_241	COG1263	PTS System
CH48_241	COG2190	(PTS) system
CH48_241	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_2410	COG0741	lytic transglycosylase activity
CH48_2411	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CH48_2412	COG1194	a g-specific adenine glycosylase
CH48_2413	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH48_2414	COG3171	Protein conserved in bacteria
CH48_2415	COG2066	Belongs to the glutaminase family
CH48_2417	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH48_2418	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH48_2419	COG1872	DUF167
CH48_242	COG1737	Transcriptional regulator
CH48_2420	COG0762	integral membrane protein
CH48_2421	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH48_2422	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH48_2423	COG2805	Type II/IV secretion system protein
CH48_2425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH48_2426	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH48_2427	COG1678	Uncharacterized ACR, COG1678
CH48_2428	COG0189	ligase activity
CH48_2429	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH48_2430	COG2356	endonuclease I
CH48_2431	COG3091	SprT-like family
CH48_2432	COG0640	Transcriptional regulator
CH48_2435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH48_2438	COG1166	arginine decarboxylase activity
CH48_2440	COG0501	Belongs to the peptidase M48B family
CH48_2441	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH48_2442	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH48_2443	COG0126	phosphoglycerate kinase activity
CH48_2444	COG0191	fructose-bisphosphate aldolase activity
CH48_2447	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH48_2449	COG1279	arginine transmembrane transporter activity
CH48_2451	COG0583	DNA-binding transcription factor activity
CH48_2452	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH48_2453	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH48_2460	COG0602	queuosine metabolic process
CH48_2463	COG0720	synthase
CH48_2464	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH48_2465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH48_2466	COG0175	sulfate reduction
CH48_2469	COG2234	aminopeptidase activity
CH48_2470	COG1648	precorrin-2 dehydrogenase activity
CH48_2470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH48_2471	COG0175	sulfate reduction
CH48_2472	COG2895	sulfate adenylyltransferase (ATP) activity
CH48_2473	COG0529	Catalyzes the synthesis of activated sulfate
CH48_2475	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH48_2477	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH48_2478	COG0585	pseudouridine synthase activity
CH48_2479	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH48_2480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH48_2481	COG1388	LysM domain
CH48_2481	COG4942	peptidase
CH48_2482	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH48_2483	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH48_2491	COG3121	Chaperone
CH48_2493	COG3539	Fimbrial protein
CH48_2494	COG3539	Fimbrial protein
CH48_2501	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_2503	COG1538	Outer membrane efflux protein
CH48_2507	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_2509	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH48_2510	COG1858	cytochrome C peroxidase
CH48_2512	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH48_2513	COG0640	Transcriptional regulator
CH48_2524	COG0410	ABC transporter
CH48_2525	COG1137	ATPase activity
CH48_2526	COG4177	L-phenylalanine transmembrane transporter activity
CH48_2527	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH48_2529	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_2529	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH48_2530	COG0243	molybdopterin cofactor binding
CH48_2531	COG0437	4 iron, 4 sulfur cluster binding
CH48_2532	COG3302	dmso reductase anchor subunit
CH48_2533	COG3381	protein complex oligomerization
CH48_2538	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH48_2539	COG2137	regulation of response to DNA damage stimulus
CH48_2540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH48_2541	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH48_2546	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_2547	COG1238	metal cluster binding
CH48_2548	COG2918	glutathione biosynthetic process
CH48_2549	COG1854	S-ribosylhomocysteine lyase activity
CH48_255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH48_2551	COG4536	flavin adenine dinucleotide binding
CH48_2552	COG4137	Cytochrome C assembly protein
CH48_2553	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH48_2554	COG0228	four-way junction DNA binding
CH48_2555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH48_2556	COG0336	Belongs to the RNA methyltransferase TrmD family
CH48_2557	COG0335	large ribosomal subunit rRNA binding
CH48_2558	COG3137	Salt-induced outer membrane protein
CH48_2559	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH48_2560	COG3279	Response regulator of the LytR AlgR family
CH48_2561	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH48_2562	COG1605	Chorismate mutase
CH48_2562	COG0287	Prephenate dehydrogenase
CH48_2563	COG0077	Prephenate dehydratase
CH48_2563	COG1605	Chorismate mutase
CH48_2566	COG0542	response to heat
CH48_2568	COG0564	pseudouridine synthase activity
CH48_2569	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH48_2570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH48_2577	COG5544	Lipoprotein
CH48_2578	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH48_2579	COG0045	succinate-CoA ligase (ADP-forming) activity
CH48_2579	COG1042	CoA-binding domain protein
CH48_2579	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH48_258	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH48_2581	COG3118	belongs to the thioredoxin family
CH48_2582	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH48_2584	COG2814	Major facilitator Superfamily
CH48_2585	COG1566	PFAM secretion protein HlyD family protein
CH48_2586	COG1538	Outer membrane efflux protein
CH48_2587	COG1846	Transcriptional regulator
CH48_2589	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH48_2590	COG2814	Major facilitator Superfamily
CH48_2598	COG0765	amino acid transport
CH48_2599	COG0765	amino acid transport
CH48_2601	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH48_2604	COG0436	Aminotransferase
CH48_2605	COG0235	Class ii aldolase
CH48_2606	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH48_2607	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH48_2608	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CH48_2609	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH48_261	COG2223	nitrite transmembrane transporter activity
CH48_2610	COG2831	hemolysin activation secretion protein
CH48_2612	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH48_2613	COG1960	acyl-CoA dehydrogenase activity
CH48_2615	COG3034	peptidoglycan biosynthetic process
CH48_2616	COG0121	glutamine amidotransferase
CH48_2617	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_2618	COG1805	sodium ion transport
CH48_2619	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_262	COG0642	Histidine kinase
CH48_262	COG2198	Histidine kinase
CH48_2620	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_2621	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH48_2622	COG2871	sodium ion transport
CH48_2623	COG1477	protein flavinylation
CH48_2624	COG2991	Protein conserved in bacteria
CH48_2626	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH48_2627	COG2964	Protein conserved in bacteria
CH48_263	COG2197	response regulator
CH48_2630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH48_2631	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH48_2632	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CH48_2635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH48_2636	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH48_2637	COG2188	Transcriptional regulator
CH48_264	COG2205	protein histidine kinase activity
CH48_264	COG0784	Response regulator, receiver
CH48_2641	COG3459	Glycosyltransferase 36 associated
CH48_2644	COG2226	methyltransferase
CH48_2649	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH48_2650	COG3123	guanosine phosphorylase activity
CH48_2651	COG2974	May be involved in recombination
CH48_2652	COG1940	carbohydrate kinase activity
CH48_2653	COG0419	ATPase involved in DNA repair
CH48_2654	COG0420	3'-5' exonuclease activity
CH48_2655	COG0745	RESPONSE REGULATOR receiver
CH48_2656	COG5002	protein histidine kinase activity
CH48_2658	COG1114	Component of the transport system for branched-chain amino acids
CH48_2660	COG0366	Alpha amylase catalytic
CH48_2664	COG0450	alkyl hydroperoxide reductase
CH48_2665	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH48_2666	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH48_2669	COG0343	queuine tRNA-ribosyltransferase activity
CH48_267	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH48_2670	COG1862	Preprotein translocase
CH48_2671	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH48_2672	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH48_2676	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH48_2677	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH48_2677	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH48_2678	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH48_2679	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH48_268	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH48_2680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH48_2681	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH48_2683	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH48_2684	COG0142	geranyltranstransferase activity
CH48_2686	COG0301	tRNA thio-modification
CH48_2686	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH48_2687	COG0693	protein deglycase activity
CH48_2688	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH48_2689	COG1666	GTP binding
CH48_2690	COG2814	Major facilitator Superfamily
CH48_2691	COG0109	protoheme IX farnesyltransferase activity
CH48_2692	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH48_2693	COG1845	cytochrome c oxidase, subunit III
CH48_2694	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH48_2695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH48_2697	COG2223	nitrite transmembrane transporter activity
CH48_2698	COG3056	Lipoprotein
CH48_2699	COG0271	Belongs to the BolA IbaG family
CH48_270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH48_2700	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH48_2701	COG0740	serine-type endopeptidase activity
CH48_2702	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH48_2703	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH48_2704	COG0776	regulation of translation
CH48_2706	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH48_2707	COG1555	photosystem II stabilization
CH48_2708	COG0824	Thioesterase
CH48_2709	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH48_271	COG4574	serine-type endopeptidase inhibitor activity
CH48_2710	COG4533	DNA binding
CH48_2711	COG0561	phosphatase activity
CH48_2713	COG1522	sequence-specific DNA binding
CH48_2714	COG1132	(ABC) transporter
CH48_2715	COG1132	(ABC) transporter
CH48_2716	COG0347	Belongs to the P(II) protein family
CH48_2717	COG0004	ammonium transporteR
CH48_2718	COG1946	Acyl-CoA thioesterase
CH48_2719	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH48_2720	COG3695	enzyme binding
CH48_2726	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_2727	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH48_2728	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH48_2729	COG0254	rRNA binding
CH48_2732	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH48_2733	COG3457	Alanine racemase
CH48_2735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_2736	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_2737	COG1309	transcriptional regulator
CH48_2738	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH48_2740	COG1196	nuclear chromosome segregation
CH48_2740	COG3264	Mechanosensitive ion channel
CH48_2742	COG2832	Protein of unknown function (DUF454)
CH48_2743	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH48_2745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH48_2746	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH48_2747	COG0326	Molecular chaperone. Has ATPase activity
CH48_2748	COG0563	adenylate kinase activity
CH48_2749	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH48_2750	COG2244	polysaccharide biosynthetic process
CH48_2751	COG1442	glycosyl transferase family 8
CH48_2751	COG1216	Glycosyl transferase, family 2
CH48_2752	COG1215	transferase activity, transferring glycosyl groups
CH48_2753	COG0438	transferase activity, transferring glycosyl groups
CH48_2755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH48_2759	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_276	COG0814	amino acid
CH48_2760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH48_2760	COG4651	solute:proton antiporter activity
CH48_2761	COG2223	nitrite transmembrane transporter activity
CH48_2762	COG0737	Belongs to the 5'-nucleotidase family
CH48_2764	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH48_2765	COG3735	TraB family
CH48_2766	COG2217	Heavy metal translocating P-type atpase
CH48_2767	COG0789	Transcriptional regulator
CH48_2768	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH48_2769	COG0330	HflC and HflK could
CH48_2770	COG3118	belongs to the thioredoxin family
CH48_2771	COG0300	oxidoreductase activity
CH48_2772	COG2755	lipolytic protein G-D-S-L family
CH48_2773	COG4181	ATPase activity
CH48_2774	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH48_2775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH48_2776	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH48_2777	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_2778	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH48_2779	COG0215	cysteine-tRNA ligase activity
CH48_2780	COG2501	S4 domain
CH48_2781	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH48_2783	COG0582	viral genome integration into host DNA
CH48_2791	COG2850	peptidyl-arginine hydroxylation
CH48_2792	COG2986	histidine ammonia-lyase
CH48_2795	COG5265	(ABC) transporter
CH48_2798	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH48_28	COG1560	Kdo2-lipid A biosynthetic process
CH48_280	COG1441	menaquinone biosynthetic process
CH48_2800	COG2197	response regulator
CH48_2801	COG1278	Cold shock
CH48_2802	COG1278	Cold shock
CH48_2803	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH48_2804	COG3706	GGDEF domain
CH48_2805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH48_2806	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH48_2807	COG0321	lipoyl(octanoyl) transferase activity
CH48_2808	COG2921	Belongs to the UPF0250 family
CH48_2809	COG1686	Belongs to the peptidase S11 family
CH48_281	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH48_2810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH48_2811	COG0772	Belongs to the SEDS family
CH48_2812	COG0768	penicillin binding
CH48_2814	COG0799	negative regulation of ribosome biogenesis
CH48_2815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH48_2816	COG1466	dna polymerase III delta subunit
CH48_2817	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH48_2818	COG0495	leucyl-tRNA aminoacylation
CH48_2819	COG2888	peptidyl-tyrosine sulfation
CH48_282	COG0596	Alpha beta hydrolase
CH48_2820	COG1126	abc transporter atp-binding protein
CH48_2821	COG0765	amino acid transport
CH48_2822	COG0765	amino acid transport
CH48_2825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH48_2826	COG4535	Mg2 and Co2 transporter CorC
CH48_2827	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH48_2828	COG1702	phosphate starvation-inducible protein PhoH
CH48_2829	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH48_283	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH48_2830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH48_2837	COG0367	asparagine synthase
CH48_2838	COG0647	UMP catabolic process
CH48_2839	COG1846	Transcriptional regulator
CH48_2839	COG1940	carbohydrate kinase activity
CH48_284	COG1169	isochorismate synthase
CH48_2840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH48_2841	COG0363	glucosamine-6-phosphate deaminase activity
CH48_2842	COG1263	PTS System
CH48_2842	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_2842	COG2190	(PTS) system
CH48_2843	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH48_2847	COG0735	belongs to the Fur family
CH48_2849	COG0840	transmembrane signaling receptor activity
CH48_285	COG3328	transposase activity
CH48_2852	COG0596	Alpha beta hydrolase
CH48_2853	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH48_2854	COG0033	Phosphoglucomutase
CH48_2857	COG0745	RESPONSE REGULATOR receiver
CH48_2858	COG2205	protein histidine kinase activity
CH48_2859	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH48_286	COG4575	ribosome binding
CH48_2860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH48_2861	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CH48_2864	COG2994	toxin metabolic process
CH48_2865	COG1073	alpha beta
CH48_2865	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH48_2865	COG3064	Membrane
CH48_2865	COG1073	alpha beta
CH48_2865	COG3064	Membrane
CH48_2865	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH48_2866	COG3272	Protein of unknown function (DUF1722)
CH48_2868	COG5212	phosphodiesterase
CH48_2869	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH48_2871	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH48_2872	COG1984	allophanate hydrolase subunit 2
CH48_2873	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH48_2876	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CH48_2878	COG2009	succinate dehydrogenase
CH48_2879	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH48_2880	COG1053	succinate dehydrogenase
CH48_2882	COG0567	Dehydrogenase, E1 component
CH48_2883	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH48_2884	COG0045	succinate-CoA ligase (ADP-forming) activity
CH48_2885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH48_2887	COG0737	Belongs to the 5'-nucleotidase family
CH48_2888	COG1271	oxidase subunit
CH48_2889	COG1294	oxidase, subunit
CH48_289	COG4702	Belongs to the UPF0303 family
CH48_2890	COG4890	Cyd operon protein YbgT
CH48_2891	COG3790	cyd operon protein YbgE
CH48_2892	COG0824	Thioesterase
CH48_2893	COG0811	peptide transport
CH48_2894	COG0848	biopolymer transport protein
CH48_2895	COG3064	Membrane
CH48_2895	COG3064	Membrane
CH48_2896	COG0823	Involved in the tonB-independent uptake of proteins
CH48_2897	COG2885	chlorophyll binding
CH48_2898	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH48_2903	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH48_2905	COG1230	cation diffusion facilitator family transporter
CH48_2906	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH48_2907	COG0588	phosphoglycerate mutase activity
CH48_291	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH48_2912	COG2017	converts alpha-aldose to the beta-anomer
CH48_2913	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH48_2914	COG1085	galactose-1-phosphate uridylyltransferase
CH48_2915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH48_2917	COG1119	ATPase activity
CH48_2918	COG3585	molybdate ion transport
CH48_2918	COG2005	Transcriptional regulator
CH48_2920	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH48_2922	COG0582	viral genome integration into host DNA
CH48_294	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_295	COG3265	gluconokinase activity
CH48_2958	COG3772	lysozyme
CH48_2960	COG4149	molybdate abc transporter
CH48_2962	COG0561	phosphatase activity
CH48_2963	COG2706	6-phosphogluconolactonase activity
CH48_2965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH48_2966	COG0156	8-amino-7-oxononanoate synthase activity
CH48_2967	COG2226	methyltransferase
CH48_2968	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH48_2970	COG0556	nucleotide-excision repair
CH48_2971	COG4628	conserved protein (DUF2132)
CH48_2972	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH48_2973	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH48_2974	COG0315	cyclic pyranopterin monophosphate synthase activity
CH48_2975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH48_2976	COG0314	molybdopterin synthase activity
CH48_2977	COG0670	Belongs to the BI1 family
CH48_2978	COG0842	Transport permease protein
CH48_2979	COG0842	Transport permease protein
CH48_2980	COG1131	(ABC) transporter
CH48_2981	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_2982	COG1309	transcriptional regulator
CH48_2983	COG0513	Belongs to the DEAD box helicase family
CH48_2984	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH48_2986	COG2239	Acts as a magnesium transporter
CH48_2988	COG1686	Belongs to the peptidase S11 family
CH48_2989	COG0277	FAD linked oxidase domain protein
CH48_299	COG1007	ATP synthesis coupled electron transport
CH48_2991	COG1403	HNH endonuclease
CH48_2993	COG2261	transglycosylase associated protein
CH48_2995	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH48_2998	COG4807	Protein conserved in bacteria
CH48_300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3002	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CH48_3004	COG2897	thiosulfate sulfurtransferase activity
CH48_3007	COG1732	Glycine betaine
CH48_3008	COG1174	glycine betaine transport
CH48_3009	COG1125	glycine betaine transport
CH48_301	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH48_3010	COG1174	glycine betaine transport
CH48_3012	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_3014	COG0583	DNA-binding transcription factor activity
CH48_3015	COG0697	spore germination
CH48_3019	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH48_302	COG0713	ATP synthesis coupled electron transport
CH48_3020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH48_3024	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH48_3026	COG1126	abc transporter atp-binding protein
CH48_3027	COG0765	amino acid transport
CH48_3028	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_3029	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH48_303	COG0839	Belongs to the complex I subunit 6 family
CH48_3030	COG0783	Belongs to the Dps family
CH48_3031	COG4106	trans-aconitate 2-methyltransferase activity
CH48_3034	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CH48_3037	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH48_304	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3041	COG0488	(ABC) transporter
CH48_3043	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH48_3044	COG0303	'Molybdopterin
CH48_3047	COG1136	(ABC) transporter
CH48_3047	COG0577	efflux transmembrane transporter activity
CH48_305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH48_3053	COG0583	DNA-binding transcription factor activity
CH48_3054	COG0477	Major facilitator Superfamily
CH48_3055	COG0302	gtp cyclohydrolase
CH48_3056	COG2311	Membrane
CH48_306	COG1034	ATP synthesis coupled electron transport
CH48_3061	COG3604	Transcriptional regulator
CH48_3062	COG3383	formate dehydrogenase (NAD+) activity
CH48_3063	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH48_3064	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH48_3066	COG3260	NADH ubiquinone oxidoreductase 20
CH48_3067	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3068	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH48_3068	COG3261	NADH dehydrogenase
CH48_3069	COG0651	ATP synthesis coupled electron transport
CH48_3070	COG4237	Hydrogenase 4 membrane
CH48_3071	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH48_3072	COG0650	Formate hydrogenlyase subunit 4
CH48_3073	COG0651	ATP synthesis coupled electron transport
CH48_3074	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH48_3075	COG0375	protein maturation
CH48_3076	COG0298	carbon dioxide binding
CH48_3077	COG2949	membrane
CH48_3078	COG0281	malic enzyme
CH48_308	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH48_3081	COG1346	cytolysis
CH48_3082	COG1380	Effector of murein hydrolase LrgA
CH48_3083	COG2814	Major facilitator Superfamily
CH48_3087	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH48_3087	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH48_3088	COG0489	protein tyrosine kinase activity
CH48_3089	COG0572	uridine kinase
CH48_309	COG0649	NAD binding
CH48_309	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3091	COG2982	Protein involved in outer membrane biogenesis
CH48_3092	COG3069	C4-dicarboxylate transmembrane transporter activity
CH48_3093	COG1253	flavin adenine dinucleotide binding
CH48_3096	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH48_3097	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH48_3098	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH48_3099	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH48_31	COG2259	Doxx family
CH48_310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3104	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH48_3106	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH48_3107	COG0140	phosphoribosyl-ATP diphosphatase activity
CH48_3107	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH48_3108	COG0107	imidazoleglycerol-phosphate synthase activity
CH48_3109	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH48_311	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH48_3111	COG0131	Imidazoleglycerol-phosphate dehydratase
CH48_3111	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH48_3112	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH48_3114	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH48_3115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_3117	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_3118	COG1129	ABC transporter
CH48_312	COG0583	DNA-binding transcription factor activity
CH48_3122	COG0531	amino acid
CH48_3123	COG2925	Exonuclease
CH48_3124	COG1022	Amp-dependent synthetase and ligase
CH48_3124	COG3320	Male sterility
CH48_3125	COG1289	transmembrane transporter activity
CH48_3126	COG2926	Belongs to the UPF0265 family
CH48_3128	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_313	COG0436	Aminotransferase
CH48_3130	COG1879	ABC-type sugar transport system periplasmic component
CH48_3132	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH48_3134	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH48_3136	COG4810	utilization protein
CH48_3138	COG4656	Part of a membrane complex involved in electron transport
CH48_314	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH48_3140	COG1012	belongs to the aldehyde dehydrogenase family
CH48_3146	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH48_315	COG0471	metal ion transport
CH48_315	COG0490	domain, Protein
CH48_3154	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH48_3158	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH48_3160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH48_3161	COG2241	protein methyltransferase activity
CH48_3163	COG2875	Belongs to the precorrin methyltransferase family
CH48_317	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_3173	COG1492	cobalamin metabolic process
CH48_3177	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH48_3178	COG2211	Major facilitator Superfamily
CH48_318	COG3013	Belongs to the UPF0304 family
CH48_319	COG3092	negative regulation of chromosome organization
CH48_3190	COG3121	Chaperone
CH48_3191	COG3188	usher protein
CH48_3200	COG3501	Rhs element vgr protein
CH48_3205	COG0137	argininosuccinate synthase activity
CH48_3206	COG0534	Mate efflux family protein
CH48_3208	COG0352	thiamine-phosphate diphosphorylase activity
CH48_3209	COG0561	phosphatase activity
CH48_321	COG0857	belongs to the CobB CobQ family
CH48_321	COG0280	phosphate acetyltransferase
CH48_3210	COG1349	DNA-binding transcription factor activity
CH48_3212	COG0784	Response regulator, receiver
CH48_3212	COG0835	chemotaxis
CH48_3214	COG4221	oxidoreductase activity
CH48_3218	COG3842	ATPase activity
CH48_322	COG1609	Transcriptional regulator
CH48_3220	COG1840	ABC-type Fe3 transport system, periplasmic component
CH48_3221	COG2271	Major facilitator Superfamily
CH48_3224	COG4565	transcriptional regulatory protein
CH48_3226	COG3290	protein histidine kinase activity
CH48_3229	COG3052	prosthetic group binding
CH48_323	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_3230	COG2301	Belongs to the HpcH HpaI aldolase family
CH48_3231	COG3051	citrate lyase alpha subunit
CH48_3232	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CH48_3232	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CH48_3234	COG0471	metal ion transport
CH48_3237	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH48_3240	COG2814	Major facilitator Superfamily
CH48_3241	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_3241	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_3242	COG3122	Protein conserved in bacteria
CH48_3246	COG3121	Chaperone
CH48_325	COG3037	sugar-specific permease SgaT UlaA
CH48_3251	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_3251	COG2205	protein histidine kinase activity
CH48_3254	COG3228	Belongs to the MtfA family
CH48_3255	COG1070	Carbohydrate kinase
CH48_3261	COG3121	Chaperone
CH48_3271	COG0604	alcohol dehydrogenase
CH48_3271	COG3321	synthase
CH48_3271	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_3273	COG3328	transposase activity
CH48_3274	COG3250	beta-galactosidase activity
CH48_3275	COG1609	Transcriptional regulator
CH48_3276	COG1278	Cold shock
CH48_3279	COG0840	transmembrane signaling receptor activity
CH48_328	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH48_3282	COG1285	pathogenesis
CH48_3284	COG2130	NADP-dependent
CH48_3285	COG0589	response to stress
CH48_3289	COG1360	Flagellar Motor Protein
CH48_329	COG0622	Phosphoesterase
CH48_3290	COG2198	Histidine kinase
CH48_3290	COG0643	Histidine kinase
CH48_3291	COG0835	chemotaxis
CH48_3292	COG0840	transmembrane signaling receptor activity
CH48_3293	COG0840	transmembrane signaling receptor activity
CH48_3294	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH48_3296	COG0745	RESPONSE REGULATOR receiver
CH48_3297	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH48_3299	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH48_3300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH48_3303	COG3418	PFAM FlgN family protein
CH48_3305	COG2747	anti-sigma28 factor FlgM
CH48_3307	COG1815	bacterial-type flagellum-dependent cell motility
CH48_3308	COG1558	bacterial-type flagellum-dependent cell motility
CH48_3309	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH48_331	COG1090	epimerase
CH48_3310	COG1749	Flagellar hook protein flgE
CH48_3312	COG4786	Flagellar basal body rod
CH48_3316	COG1256	bacterial-type flagellum assembly
CH48_3320	COG1338	Plays a role in the flagellum-specific transport system
CH48_3324	COG1580	Controls the rotational direction of flagella during chemotaxis
CH48_3326	COG2882	bacterial-type flagellum organization
CH48_3328	COG1317	bacterial-type flagellum organization
CH48_3329	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH48_333	COG4598	ABC transporter
CH48_3331	COG1677	Flagellar hook-basal body complex protein FliE
CH48_3336	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH48_3337	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH48_334	COG4160	amino acid transport
CH48_3346	COG1191	sigma factor activity
CH48_3348	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH48_335	COG4215	(ABC) transporter
CH48_3355	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH48_3355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH48_3355	COG0506	proline dehydrogenase activity
CH48_3359	COG3157	Type VI secretion system effector, Hcp
CH48_336	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH48_3363	COG0655	NAD(P)H dehydrogenase (quinone) activity
CH48_3365	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH48_3366	COG2233	PERMEase
CH48_3369	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH48_337	COG0163	prenyltransferase activity
CH48_3370	COG0778	Nitroreductase
CH48_3371	COG2267	carboxylic ester hydrolase activity
CH48_3372	COG0251	oxidation-reduction process
CH48_3373	COG1335	isochorismatase
CH48_3374	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH48_3375	COG1309	transcriptional regulator
CH48_3376	COG1113	amino acid transport
CH48_3378	COG2963	transposase activity
CH48_3379	COG2226	methyltransferase
CH48_338	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH48_3382	COG0366	Alpha amylase catalytic
CH48_3384	COG3136	membrane protein required for alginate biosynthesis
CH48_3386	COG2197	response regulator
CH48_3387	COG0322	excinuclease ABC activity
CH48_3388	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH48_339	COG1286	toxin biosynthetic process
CH48_34	COG3104	oligopeptide transport
CH48_340	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH48_3406	COG3077	Addiction module antitoxin, RelB DinJ family
CH48_3407	COG3041	Addiction module toxin RelE StbE family
CH48_341	COG0285	dihydrofolate synthase activity
CH48_342	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CH48_3425	COG2801	Transposase and inactivated derivatives
CH48_3427	COG3328	transposase activity
CH48_343	COG0586	Pfam SNARE associated Golgi protein
CH48_3437	COG3772	lysozyme
CH48_3438	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CH48_3439	COG2979	Protein of unknown function (DUF533)
CH48_3442	COG0012	GTP binding
CH48_3444	COG0193	aminoacyl-tRNA hydrolase activity
CH48_3447	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH48_3449	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH48_345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH48_3450	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH48_3451	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH48_3452	COG2890	protein-(glutamine-N5) methyltransferase activity
CH48_3453	COG3094	Invasion gene expression up-regulator, SirB
CH48_3454	COG2912	Transglutaminase-like superfamily
CH48_3455	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CH48_3456	COG0659	secondary active sulfate transmembrane transporter activity
CH48_3458	COG3706	GGDEF domain
CH48_3462	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH48_3463	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH48_3464	COG3381	protein complex oligomerization
CH48_3466	COG0477	Major facilitator Superfamily
CH48_3469	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH48_3471	COG0673	inositol 2-dehydrogenase activity
CH48_3472	COG0728	peptidoglycan biosynthetic process
CH48_3473	COG0387	Pfam Sodium calcium exchanger
CH48_3477	COG0583	DNA-binding transcription factor activity
CH48_3478	COG3850	Histidine kinase
CH48_3479	COG1294	oxidase, subunit
CH48_348	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH48_3480	COG1271	oxidase subunit
CH48_3481	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_3482	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH48_3483	COG3138	arginine N-succinyltransferase
CH48_3485	COG3724	N-succinylarginine dihydrolase activity
CH48_3486	COG2988	succinylglutamate desuccinylase activity
CH48_3492	COG1228	amidohydrolase
CH48_3494	COG0402	S-adenosylhomocysteine deaminase activity
CH48_3496	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH48_350	COG0697	spore germination
CH48_3500	COG4942	peptidase
CH48_3502	COG2222	sugar isomerase
CH48_3503	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_3504	COG3716	PTS system mannose fructose sorbose family IID component
CH48_3506	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_3508	COG1349	DNA-binding transcription factor activity
CH48_351	COG0697	spore germination
CH48_3512	COG1187	pseudouridine synthase activity
CH48_3513	COG0786	glutamate:sodium symporter activity
CH48_3517	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH48_3518	COG2226	methyltransferase
CH48_3519	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH48_352	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH48_3520	COG1801	Protein of unknown function DUF72
CH48_3521	COG1335	isochorismatase
CH48_3522	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH48_3523	COG0494	nUDIX hydrolase
CH48_3524	COG0217	transcriptional regulatory protein
CH48_3525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH48_3526	COG0632	four-way junction helicase activity
CH48_3527	COG2255	four-way junction helicase activity
CH48_3528	COG3104	oligopeptide transport
CH48_3529	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_353	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH48_3530	COG1121	(ABC) transporter
CH48_3531	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH48_3532	COG0739	heme binding
CH48_3533	COG1560	Kdo2-lipid A biosynthetic process
CH48_3535	COG3328	transposase activity
CH48_3536	COG0469	pyruvate kinase activity
CH48_3537	COG1737	Transcriptional regulator
CH48_3538	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH48_3539	COG0800	Aldolase
CH48_3540	COG2076	Multidrug Resistance protein
CH48_3541	COG2076	Multidrug Resistance protein
CH48_3542	COG0251	oxidation-reduction process
CH48_3543	COG1199	ATP-dependent helicase activity
CH48_3545	COG3065	identical protein binding
CH48_3546	COG0318	PFAM AMP-dependent synthetase and ligase
CH48_3547	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH48_3548	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH48_3549	COG2894	cell division
CH48_3550	COG0850	regulation of cytokinetic process
CH48_3552	COG3100	YcgL domain-containing protein
CH48_3553	COG2951	lytic endotransglycosylase activity
CH48_3554	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH48_3555	COG2983	Belongs to the UPF0260 family
CH48_3560	COG0668	transmembrane transport
CH48_3561	COG0625	glutathione transferase activity
CH48_3567	COG5001	Diguanylate cyclase
CH48_3567	COG3706	GGDEF domain
CH48_3567	COG2203	Gaf domain
CH48_3567	COG4251	negative regulation of phosphorylation
CH48_357	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH48_3574	COG2814	Major facilitator Superfamily
CH48_3576	COG3008	intermembrane lipid transfer
CH48_3577	COG2995	paraquat-inducible protein a
CH48_3578	COG1956	GAF domain-containing protein
CH48_3580	COG0793	Belongs to the peptidase S41A family
CH48_3581	COG0501	Belongs to the peptidase M48B family
CH48_3582	COG2814	Major facilitator Superfamily
CH48_3583	COG0823	Involved in the tonB-independent uptake of proteins
CH48_3585	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH48_3587	COG1988	membrane-bound metal-dependent
CH48_3588	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH48_3589	COG1653	transport
CH48_359	COG1609	Transcriptional regulator
CH48_3590	COG3842	ATPase activity
CH48_3591	COG0395	ABC-type sugar transport system, permease component
CH48_3592	COG1175	transmembrane transport
CH48_3594	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_3595	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH48_3596	COG1917	Cupin 2, conserved barrel domain protein
CH48_3597	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH48_3599	COG0427	acetyl-CoA hydrolase
CH48_3600	COG0583	DNA-binding transcription factor activity
CH48_3601	COG1024	Enoyl-CoA hydratase
CH48_3602	COG1703	isobutyryl-CoA mutase activity
CH48_3603	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH48_3603	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH48_3605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_3606	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH48_3607	COG1121	(ABC) transporter
CH48_3608	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH48_361	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_3615	COG1811	Na channel or pump
CH48_3616	COG4249	Peptidase C14 caspase catalytic subunit p20
CH48_3617	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH48_3618	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH48_3619	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH48_362	COG2723	6-phospho-beta-galactosidase activity
CH48_3620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CH48_3621	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH48_3623	COG0776	regulation of translation
CH48_3624	COG2314	TM2 domain
CH48_3626	COG4139	cobalamin transport
CH48_3627	COG0386	Belongs to the glutathione peroxidase family
CH48_3628	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH48_3629	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH48_363	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH48_3630	COG0463	Glycosyl transferase, family 2
CH48_3631	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH48_3631	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH48_3632	COG0726	polysaccharide deacetylase
CH48_3633	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH48_3634	COG2076	Multidrug Resistance protein
CH48_3635	COG2076	Multidrug Resistance protein
CH48_3636	COG0791	NLP P60 protein
CH48_3637	COG0095	Lipoate-protein ligase
CH48_3639	COG4558	Periplasmic binding protein
CH48_3640	COG3720	iron ion transport
CH48_3643	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH48_3645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH48_3645	COG0574	Belongs to the PEP-utilizing enzyme family
CH48_3646	COG0628	permease
CH48_3647	COG0277	FAD linked oxidase domain protein
CH48_3647	COG0247	lactate metabolic process
CH48_3649	COG2050	protein possibly involved in aromatic compounds catabolism
CH48_365	COG1794	racemase activity, acting on amino acids and derivatives
CH48_3650	COG0316	Belongs to the HesB IscA family
CH48_3651	COG0719	Fe-S assembly protein
CH48_3652	COG0396	ATPase activity
CH48_3653	COG0719	Fe-S assembly protein
CH48_3655	COG2166	iron-sulfur cluster assembly
CH48_3656	COG1388	LysM domain
CH48_3656	COG1376	ErfK ybiS ycfS ynhG family protein
CH48_3657	COG4238	major outer membrane lipoprotein
CH48_366	COG3706	GGDEF domain
CH48_3662	COG0534	Mate efflux family protein
CH48_3663	COG0307	riboflavin synthase, alpha
CH48_3664	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH48_3665	COG2814	Major facilitator Superfamily
CH48_3666	COG0583	DNA-binding transcription factor activity
CH48_3667	COG1609	Transcriptional regulator
CH48_3669	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH48_367	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH48_3670	COG0791	NLP P60 protein
CH48_3671	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH48_3672	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH48_3673	COG0346	lactoylglutathione lyase activity
CH48_3674	COG1902	pentaerythritol trinitrate reductase activity
CH48_3675	COG1309	transcriptional regulator
CH48_3676	COG2194	sulfuric ester hydrolase activity
CH48_3677	COG3313	Fe-S protein
CH48_3678	COG4989	oxidoreductase activity
CH48_3679	COG1289	transmembrane transporter activity
CH48_368	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH48_368	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH48_3680	COG1566	PFAM secretion protein HlyD family protein
CH48_3682	COG1846	Transcriptional regulator
CH48_3683	COG3133	Outer membrane lipoprotein
CH48_3685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH48_3686	COG3895	Periplasmic Protein
CH48_3687	COG0259	pyridoxamine-phosphate oxidase activity
CH48_3688	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH48_3690	COG0625	glutathione transferase activity
CH48_3694	COG3104	oligopeptide transport
CH48_3699	COG4172	Belongs to the ABC transporter superfamily
CH48_370	COG3101	peptidyl-lysine hydroxylation
CH48_3701	COG4171	peptide transport system, permease
CH48_3702	COG4168	peptide transport system, permease
CH48_3703	COG4166	transmembrane transport
CH48_3706	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH48_3707	COG1842	Phage shock protein A
CH48_3709	COG1983	PspC domain protein
CH48_371	COG0730	response to heat
CH48_3711	COG3106	COG3106 Predicted ATPase
CH48_3712	COG3768	UPF0283 membrane protein
CH48_3716	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH48_3717	COG2866	Carboxypeptidase
CH48_3718	COG4948	Mandelate Racemase Muconate Lactonizing
CH48_3719	COG4166	transmembrane transport
CH48_372	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH48_3720	COG0598	Magnesium transport protein CorA
CH48_3721	COG0037	tRNA processing
CH48_3722	COG0823	Involved in the tonB-independent uptake of proteins
CH48_3723	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH48_3723	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH48_3723	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH48_3723	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH48_3725	COG1285	pathogenesis
CH48_3726	COG3042	response to heat
CH48_3727	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH48_3728	COG2911	Protein conserved in bacteria
CH48_373	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH48_3730	COG3784	Protein of unknown function (DUF1318)
CH48_3731	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH48_3732	COG1643	Atp-dependent helicase
CH48_3735	COG3591	Belongs to the peptidase S1B family
CH48_3737	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH48_3738	COG2205	protein histidine kinase activity
CH48_3739	COG0745	RESPONSE REGULATOR receiver
CH48_374	COG2890	protein-(glutamine-N5) methyltransferase activity
CH48_3741	COG0531	amino acid
CH48_3743	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH48_3744	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH48_3745	COG0589	response to stress
CH48_3746	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH48_3747	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH48_3750	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH48_3751	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_3753	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH48_3755	COG0738	Major facilitator superfamily
CH48_3757	COG1011	Hydrolase
CH48_3758	COG0440	acetolactate synthase activity
CH48_3759	COG0028	Belongs to the TPP enzyme family
CH48_3761	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH48_3766	COG2271	Major facilitator Superfamily
CH48_3767	COG0483	inositol monophosphate 1-phosphatase activity
CH48_3769	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH48_377	COG2840	Smr protein MutS2
CH48_3772	COG3177	Filamentation induced by cAMP protein fic
CH48_3778	COG4215	(ABC) transporter
CH48_378	COG2062	phosphohistidine phosphatase, SixA
CH48_3780	COG1522	sequence-specific DNA binding
CH48_3785	COG0625	glutathione transferase activity
CH48_379	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH48_379	COG1024	Enoyl-CoA hydratase
CH48_38	COG5645	(Lipo)protein
CH48_380	COG0183	Belongs to the thiolase family
CH48_381	COG3691	Protein conserved in bacteria
CH48_3818	COG4221	oxidoreductase activity
CH48_3819	COG1742	UPF0060 membrane protein
CH48_3825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH48_3826	COG1940	carbohydrate kinase activity
CH48_3827	COG0583	DNA-binding transcription factor activity
CH48_3828	COG2814	Major facilitator Superfamily
CH48_3833	COG0114	fumarate hydratase activity
CH48_3835	COG5339	Protein conserved in bacteria
CH48_3837	COG1609	Transcriptional regulator
CH48_3838	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_3838	COG1263	PTS System
CH48_3839	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH48_384	COG3088	subunit of a heme lyase
CH48_384	COG4235	cytochrome complex assembly
CH48_3840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH48_3841	COG0385	Bile acid
CH48_3842	COG0673	inositol 2-dehydrogenase activity
CH48_3844	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH48_3846	COG1879	ABC-type sugar transport system periplasmic component
CH48_3848	COG2160	L-arabinose isomerase activity
CH48_3849	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH48_3850	COG2274	protein secretion by the type I secretion system
CH48_3854	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH48_3856	COG4657	Part of a membrane complex involved in electron transport
CH48_3858	COG4656	Part of a membrane complex involved in electron transport
CH48_386	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH48_3861	COG3708	Transcriptional regulator
CH48_3861	COG2207	Transcriptional regulator
CH48_3862	COG4658	electron transport chain
CH48_3863	COG4659	FMN binding
CH48_3865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH48_387	COG1138	Cytochrome C-type biogenesis protein
CH48_3871	COG0243	molybdopterin cofactor binding
CH48_3872	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH48_3873	COG1966	Carbon starvation protein
CH48_3874	COG2879	small protein
CH48_3875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH48_3876	COG1349	DNA-binding transcription factor activity
CH48_3878	COG0235	Class ii aldolase
CH48_388	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH48_3881	COG0023	Translation Initiation Factor
CH48_3882	COG0284	orotidine-5'-phosphate decarboxylase activity
CH48_3884	COG3135	benzoate transporter
CH48_3885	COG1396	sequence-specific DNA binding
CH48_3887	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH48_3888	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH48_3889	COG0671	phosphoesterase, PA-phosphatase related
CH48_389	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH48_3890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH48_3894	COG0583	DNA-binding transcription factor activity
CH48_3895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH48_3897	COG0616	signal peptide processing
CH48_3898	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_3899	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH48_39	COG2943	transferase activity, transferring hexosyl groups
CH48_390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH48_3901	COG1187	pseudouridine synthase activity
CH48_3902	COG0009	L-threonylcarbamoyladenylate synthase
CH48_3903	COG0613	PHP domain protein
CH48_3905	COG0512	Glutamine amidotransferase of anthranilate synthase
CH48_3907	COG0134	indole-3-glycerol-phosphate synthase activity
CH48_3907	COG0135	phosphoribosylanthranilate isomerase activity
CH48_3908	COG0133	tryptophan synthase activity
CH48_3909	COG0159	tryptophan synthase activity
CH48_391	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH48_3911	COG3047	cAMP biosynthetic process
CH48_3915	COG2917	probably involved in intracellular septation
CH48_3916	COG1607	acyl-coa hydrolase
CH48_3917	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH48_3918	COG2350	Protein conserved in bacteria
CH48_3922	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH48_3923	COG3099	Belongs to the UPF0263 family
CH48_3925	COG0444	Belongs to the ABC transporter superfamily
CH48_3926	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_3930	COG2095	MarC family integral membrane protein
CH48_3931	COG1454	alcohol dehydrogenase
CH48_3931	COG1012	belongs to the aldehyde dehydrogenase family
CH48_3932	COG1435	thymidine kinase activity
CH48_3933	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH48_3935	COG0745	RESPONSE REGULATOR receiver
CH48_3936	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH48_3937	COG3012	SEC-C Motif Domain Protein
CH48_3938	COG0788	formyltetrahydrofolate deformylase activity
CH48_394	COG0837	glucose binding
CH48_3942	COG0583	DNA-binding transcription factor activity
CH48_3943	COG0708	Exodeoxyribonuclease III
CH48_3944	COG0494	nUDIX hydrolase
CH48_3946	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH48_3948	COG0778	Nitroreductase
CH48_3949	COG0616	signal peptide processing
CH48_3950	COG0252	asparaginase activity
CH48_3951	COG1335	isochorismatase
CH48_3953	COG3139	Protein of unknown function (DUF1315)
CH48_3954	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH48_3957	COG3713	MltA-interacting MipA family protein
CH48_3958	COG2766	serine protein kinase
CH48_3959	COG2718	Belongs to the UPF0229 family
CH48_396	COG3961	Belongs to the TPP enzyme family
CH48_3962	COG0583	DNA-binding transcription factor activity
CH48_3964	COG2202	Pas domain
CH48_3964	COG2200	EAL domain
CH48_3964	COG2199	diguanylate cyclase activity
CH48_3965	COG2814	Major facilitator Superfamily
CH48_3966	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH48_3967	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH48_3968	COG2719	SpoVR family
CH48_3969	COG2186	Transcriptional regulator
CH48_3970	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH48_3971	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH48_3972	COG3142	Participates in the control of copper homeostasis
CH48_3974	COG3102	Protein conserved in bacteria
CH48_3975	COG0018	arginyl-trna synthetase
CH48_3977	COG1702	phosphate starvation-inducible protein PhoH
CH48_3979	COG3658	cytochrome
CH48_398	COG0667	Aldo Keto reductase
CH48_3980	COG1215	transferase activity, transferring glycosyl groups
CH48_3981	COG0726	polysaccharide deacetylase
CH48_3981	COG1649	PFAM Uncharacterised BCR, COG1649
CH48_3982	COG0457	Tetratricopeptide repeat
CH48_3984	COG0006	proline dipeptidase activity
CH48_3985	COG4114	ferric iron reductase
CH48_3986	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH48_3991	COG0577	efflux transmembrane transporter activity
CH48_3991	COG1136	(ABC) transporter
CH48_3993	COG0577	efflux transmembrane transporter activity
CH48_3993	COG1136	(ABC) transporter
CH48_3996	COG0672	)-iron permease
CH48_3999	COG2066	Belongs to the glutaminase family
CH48_4	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_400	COG1914	H( )-stimulated, divalent metal cation uptake system
CH48_4000	COG3622	Belongs to the hyi family
CH48_4001	COG0235	Class ii aldolase
CH48_4002	COG3395	kinase activity
CH48_4003	COG1349	DNA-binding transcription factor activity
CH48_4004	COG3290	protein histidine kinase activity
CH48_4005	COG4565	transcriptional regulatory protein
CH48_4006	COG3493	citrate carrier protein
CH48_401	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH48_4010	COG2223	nitrite transmembrane transporter activity
CH48_4011	COG0561	phosphatase activity
CH48_4013	COG3328	transposase activity
CH48_4015	COG0500	methyltransferase
CH48_4016	COG3328	transposase activity
CH48_4025	COG4974	Belongs to the 'phage' integrase family
CH48_4027	COG1276	copper resistance
CH48_4028	COG2372	response to copper ion
CH48_4029	COG1528	Iron-storage protein
CH48_4033	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH48_4034	COG1770	oligopeptidase
CH48_4037	COG3141	response to X-ray
CH48_4038	COG0513	Belongs to the DEAD box helicase family
CH48_4039	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH48_4040	COG3140	Belongs to the UPF0181 family
CH48_4042	COG0494	nUDIX hydrolase
CH48_4043	COG1760	l-serine dehydratase
CH48_4046	COG1253	flavin adenine dinucleotide binding
CH48_4047	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_4047	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_4048	COG3715	PTS system
CH48_4049	COG3716	PTS system mannose fructose sorbose family IID component
CH48_4050	COG4811	Protein of unknown function (DUF986)
CH48_4051	COG1971	Probably functions as a manganese efflux pump
CH48_4053	COG3447	MASE1 domain protein
CH48_4053	COG5001	Diguanylate cyclase
CH48_4053	COG5002	protein histidine kinase activity
CH48_4055	COG2226	methyltransferase
CH48_4056	COG0768	penicillin binding
CH48_4058	COG1278	Cold shock
CH48_406	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH48_4061	COG1113	amino acid transport
CH48_4068	COG2207	Transcriptional regulator
CH48_4072	COG1132	(ABC) transporter
CH48_4076	COG5001	Diguanylate cyclase
CH48_4076	COG4251	negative regulation of phosphorylation
CH48_4076	COG3706	GGDEF domain
CH48_4076	COG2203	Gaf domain
CH48_4079	COG3755	Protein conserved in bacteria
CH48_4086	COG1733	regulation of RNA biosynthetic process
CH48_4087	COG0702	epimerase
CH48_4088	COG2873	o-acetylhomoserine
CH48_4092	COG0840	transmembrane signaling receptor activity
CH48_41	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH48_4100	COG0538	isocitrate dehydrogenase activity
CH48_4106	COG0538	isocitrate dehydrogenase activity
CH48_4107	COG1187	pseudouridine synthase activity
CH48_4109	COG0482	sulfurtransferase activity
CH48_411	COG3530	Putative quorum-sensing-regulated virulence factor
CH48_4110	COG2915	High frequency lysogenization protein hflD homolog
CH48_4111	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH48_4113	COG0745	RESPONSE REGULATOR receiver
CH48_4115	COG2850	peptidyl-arginine hydroxylation
CH48_4117	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH48_4118	COG1940	carbohydrate kinase activity
CH48_4119	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH48_412	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH48_4121	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH48_4122	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH48_4123	COG3134	Outer membrane lipoprotein
CH48_4125	COG1252	NADH dehydrogenase
CH48_4126	COG3150	esterase
CH48_4127	COG1472	Belongs to the glycosyl hydrolase 3 family
CH48_4129	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH48_4130	COG5633	Lipoprotein
CH48_4131	COG0537	adenosine 5'-monophosphoramidase activity
CH48_4132	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH48_4135	COG0641	radical SAM
CH48_4139	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH48_4139	COG1263	PTS System
CH48_4140	COG0084	hydrolase, TatD family'
CH48_4141	COG0470	DNA polymerase III
CH48_4142	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH48_4143	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH48_415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH48_4152	COG2801	Transposase and inactivated derivatives
CH48_4156	COG2963	transposase activity
CH48_4157	COG2963	transposase activity
CH48_416	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_4162	COG0431	NADPH-dependent FMN reductase
CH48_4163	COG0640	Transcriptional regulator
CH48_417	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH48_4177	COG2963	transposase activity
CH48_4178	COG2963	transposase activity
CH48_418	COG2190	(PTS) system
CH48_4181	COG1192	Involved in chromosome partitioning
CH48_4182	COG1475	DNA binding
CH48_4183	COG3609	addiction module antidote protein, CC2985 family
CH48_419	COG2205	protein histidine kinase activity
CH48_420	COG0745	RESPONSE REGULATOR receiver
CH48_4204	COG4792	protein secretion
CH48_4205	COG4791	protein targeting
CH48_4206	COG4794	Type iii secretion
CH48_4207	COG4790	Type iii secretion
CH48_4208	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH48_421	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_4225	COG3328	transposase activity
CH48_4226	COG4886	Leucine-rich repeat (LRR) protein
CH48_4226	COG4886	Leucine-rich repeat (LRR) protein
CH48_4231	COG2963	transposase activity
CH48_4232	COG2963	transposase activity
CH48_425	COG4208	sulfate ABC transporter
CH48_426	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH48_427	COG4150	thiosulfate binding
CH48_429	COG1737	Transcriptional regulator
CH48_430	COG2731	YhcH YjgK YiaL family protein
CH48_433	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH48_435	COG2837	iron assimilation
CH48_437	COG3111	PFAM Bacterial OB fold (BOF) protein
CH48_438	COG0456	acetyltransferase
CH48_439	COG0408	coproporphyrinogen oxidase activity
CH48_440	COG1671	Belongs to the UPF0178 family
CH48_444	COG0281	malic enzyme
CH48_444	COG0280	phosphate acetyltransferase
CH48_445	COG0494	nUDIX hydrolase
CH48_446	COG3005	denitrification pathway
CH48_447	COG3043	anaerobic respiration
CH48_448	COG0243	molybdopterin cofactor binding
CH48_449	COG3062	negative regulation of establishment of protein localization
CH48_45	COG3263	regulation of cellular component size
CH48_451	COG2197	response regulator
CH48_453	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_457	COG1393	Belongs to the ArsC family
CH48_458	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH48_459	COG1876	peptidase activity
CH48_469	COG0400	carboxylic ester hydrolase activity
CH48_47	COG2771	luxR family
CH48_471	COG1444	tRNA N-acetyltransferase activity
CH48_472	COG2707	UPF0756 membrane protein
CH48_473	COG2321	neutral zinc metallopeptidase
CH48_474	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH48_475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH48_476	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH48_477	COG2716	regulation of RNA biosynthetic process
CH48_478	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH48_479	COG0628	permease
CH48_48	COG3916	Acyl-homoserine-lactone synthase
CH48_480	COG4783	chaperone-mediated protein folding
CH48_481	COG1393	Belongs to the ArsC family
CH48_482	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH48_483	COG2233	PERMEase
CH48_484	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH48_485	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH48_486	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH48_487	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH48_49	COG4235	cytochrome complex assembly
CH48_491	COG0581	inorganic phosphate transmembrane transporter activity
CH48_492	COG0573	inorganic phosphate transmembrane transporter activity
CH48_493	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH48_494	COG0248	Ppx GppA phosphatase
CH48_496	COG2239	Acts as a magnesium transporter
CH48_497	COG5002	protein histidine kinase activity
CH48_497	COG5001	Diguanylate cyclase
CH48_497	COG3447	MASE1 domain protein
CH48_498	COG0443	Heat shock 70 kDa protein
CH48_5	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH48_50	COG3088	subunit of a heme lyase
CH48_500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH48_502	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH48_504	COG0477	Major facilitator Superfamily
CH48_505	COG2205	protein histidine kinase activity
CH48_506	COG0745	RESPONSE REGULATOR receiver
CH48_507	COG3422	double-strand break repair
CH48_509	COG1597	lipid kinase activity
CH48_51	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH48_510	COG3730	PTS system glucitol sorbitol-specific
CH48_513	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_514	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH48_515	COG1349	DNA-binding transcription factor activity
CH48_52	COG1138	Cytochrome C-type biogenesis protein
CH48_520	COG0351	phosphomethylpyrimidine kinase
CH48_527	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH48_527	COG0519	Catalyzes the synthesis of GMP from XMP
CH48_528	COG0516	GMP reductase activity
CH48_528	COG0517	IMP dehydrogenase activity
CH48_529	COG1570	exodeoxyribonuclease VII activity
CH48_53	COG3301	Polysulphide reductase, NrfD
CH48_530	COG1645	bacterial-type flagellum-dependent swarming motility
CH48_533	COG1160	GTP binding
CH48_534	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH48_535	COG2976	Protein conserved in bacteria
CH48_536	COG0124	histidyl-tRNA synthetase
CH48_537	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CH48_538	COG1426	Protein conserved in bacteria
CH48_54	COG0437	4 iron, 4 sulfur cluster binding
CH48_540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH48_543	COG4953	penicillin-binding protein 1C
CH48_544	COG2373	Large extracellular alpha-helical protein
CH48_546	COG3468	outer membrane autotransporter barrel domain protein
CH48_549	COG2975	iron-sulfur cluster assembly
CH48_55	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH48_550	COG0633	Ferredoxin
CH48_551	COG0443	Heat shock 70 kDa protein
CH48_552	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH48_553	COG0316	Belongs to the HesB IscA family
CH48_554	COG0822	iron-sulfur transferase activity
CH48_556	COG1959	2 iron, 2 sulfur cluster binding
CH48_557	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH48_558	COG0483	inositol monophosphate 1-phosphatase activity
CH48_559	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH48_560	COG3683	transport system, periplasmic component
CH48_561	COG2814	Major facilitator Superfamily
CH48_562	COG3711	transcriptional antiterminator
CH48_563	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH48_564	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH48_564	COG1017	nitric oxide dioxygenase activity
CH48_568	COG3457	Alanine racemase
CH48_569	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CH48_572	COG0347	Belongs to the P(II) protein family
CH48_573	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH48_573	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH48_574	COG2204	response regulator
CH48_575	COG3170	Tfp pilus assembly protein FimV
CH48_576	COG2205	protein histidine kinase activity
CH48_579	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH48_58	COG2920	part of a sulfur-relay system
CH48_580	COG0590	tRNA wobble adenosine to inosine editing
CH48_582	COG0560	Phosphoserine phosphatase
CH48_584	COG1737	Transcriptional regulator
CH48_585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH48_586	COG2610	gluconate transmembrane transporter activity
CH48_587	COG0736	holo-[acyl-carrier-protein] synthase activity
CH48_588	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH48_589	COG1381	Involved in DNA repair and RecF pathway recombination
CH48_59	COG1254	Belongs to the acylphosphatase family
CH48_590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH48_591	COG0571	ribonuclease III activity
CH48_592	COG0681	Belongs to the peptidase S26 family
CH48_593	COG0481	GTPase activity
CH48_595	COG3086	response to oxidative stress
CH48_597	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH48_599	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH48_6	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH48_600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH48_601	COG0513	Belongs to the DEAD box helicase family
CH48_607	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH48_608	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH48_609	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH48_610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH48_611	COG0497	DNA recombination
CH48_612	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH48_615	COG2867	negative regulation of translational initiation
CH48_616	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH48_617	COG0582	viral genome integration into host DNA
CH48_62	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH48_626	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH48_63	COG3785	DNA binding
CH48_630	COG3394	polysaccharide catabolic process
CH48_631	COG1917	Cupin 2, conserved barrel domain protein
CH48_631	COG2169	Transcriptional regulator
CH48_632	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH48_633	COG2723	6-phospho-beta-galactosidase activity
CH48_634	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH48_636	COG2133	pyrroloquinoline quinone binding
CH48_638	COG0667	Aldo Keto reductase
CH48_64	COG1832	CoA-binding protein
CH48_641	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH48_642	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH48_644	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH48_645	COG4413	Urea transporter
CH48_646	COG0829	nickel cation binding
CH48_647	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH48_648	COG0830	nickel cation binding
CH48_649	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH48_65	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH48_650	COG0804	urea catabolic process
CH48_651	COG0832	Belongs to the urease beta subunit family
CH48_653	COG1124	(ABC) transporter
CH48_655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH48_66	COG1803	Methylglyoxal synthase
CH48_662	COG1278	Cold shock
CH48_666	COG0477	Major facilitator Superfamily
CH48_667	COG2207	Transcriptional regulator
CH48_67	COG0210	DNA helicase
CH48_671	COG4575	ribosome binding
CH48_673	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH48_675	COG1780	Probably involved in ribonucleotide reductase function
CH48_677	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH48_679	COG4176	ABC-type proline glycine betaine transport system permease component
CH48_68	COG3304	Inner membrane component domain
CH48_680	COG2113	Glycine betaine
CH48_682	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH48_683	COG0328	RNA-DNA hybrid ribonuclease activity
CH48_684	COG2226	methyltransferase
CH48_685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH48_686	COG1388	LysM domain
CH48_686	COG0741	lytic transglycosylase activity
CH48_689	COG3021	interspecies interaction between organisms
CH48_69	COG1289	transmembrane transporter activity
CH48_690	COG2814	Major facilitator Superfamily
CH48_691	COG0583	DNA-binding transcription factor activity
CH48_692	COG0656	L-ascorbic acid biosynthetic process
CH48_694	COG3328	transposase activity
CH48_7	COG0416	fatty acid biosynthetic process
CH48_70	COG3070	regulator of competence-specific genes
CH48_702	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH48_704	COG2011	ABC-type metal ion transport system permease component
CH48_705	COG1464	Belongs to the NlpA lipoprotein family
CH48_707	COG1720	tRNA m6t6A37 methyltransferase activity
CH48_708	COG0442	prolyl-tRNA aminoacylation
CH48_709	COG3015	lipoprotein NlpE involved in copper resistance
CH48_71	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH48_711	COG4681	YaeQ
CH48_713	COG4568	rho-dependent transcription termination
CH48_715	COG0037	tRNA processing
CH48_716	COG0346	lactoylglutathione lyase activity
CH48_718	COG0825	malonyl-CoA metabolic process
CH48_72	COG2885	chlorophyll binding
CH48_72	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH48_720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH48_721	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_722	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_723	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH48_724	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH48_725	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH48_727	COG0750	zinc metalloprotease
CH48_728	COG0575	Belongs to the CDS family
CH48_729	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH48_73	COG3120	sequence-specific DNA binding
CH48_730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH48_731	COG0233	cytoplasmic translational termination
CH48_732	COG0528	UMP kinase activity
CH48_733	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH48_734	COG0052	Belongs to the universal ribosomal protein uS2 family
CH48_735	COG0024	Methionine aminopeptidase
CH48_736	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH48_737	COG2171	N-acyltransferase activity
CH48_74	COG1067	ATP-dependent peptidase activity
CH48_740	COG0564	pseudouridine synthase activity
CH48_741	COG3098	single-species biofilm formation
CH48_743	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH48_743	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH48_744	COG1611	Belongs to the LOG family
CH48_745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH48_748	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH48_749	COG2363	Small membrane protein
CH48_75	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH48_750	COG0583	DNA-binding transcription factor activity
CH48_752	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH48_753	COG2166	iron-sulfur cluster assembly
CH48_754	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH48_755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH48_759	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH48_760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH48_760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH48_763	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH48_764	COG1074	ATP-dependent DNA helicase activity
CH48_765	COG1025	Belongs to the peptidase M16 family
CH48_766	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH48_770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CH48_771	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH48_773	COG1051	belongs to the nudix hydrolase family
CH48_774	COG3066	DNA modification
CH48_775	COG0861	Integral membrane protein TerC family
CH48_776	COG0667	Aldo Keto reductase
CH48_777	COG0477	Major facilitator Superfamily
CH48_778	COG0318	PFAM AMP-dependent synthetase and ligase
CH48_778	COG0204	Acyl-transferase
CH48_78	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH48_781	COG1609	Transcriptional regulator
CH48_782	COG0019	diaminopimelate decarboxylase activity
CH48_783	COG2814	Major facilitator Superfamily
CH48_784	COG0583	DNA-binding transcription factor activity
CH48_787	COG0840	transmembrane signaling receptor activity
CH48_79	COG3130	regulation of translation
CH48_792	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH48_8	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH48_80	COG3009	Protein conserved in bacteria
CH48_800	COG2165	general secretion pathway protein
CH48_806	COG0288	reversible hydration of carbon dioxide
CH48_807	COG1733	regulation of RNA biosynthetic process
CH48_808	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_81	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH48_81	COG3008	intermembrane lipid transfer
CH48_810	COG0484	heat shock protein binding
CH48_812	COG3706	GGDEF domain
CH48_813	COG4319	ketosteroid isomerase
CH48_816	COG3328	transposase activity
CH48_817	COG2944	sequence-specific DNA binding
CH48_82	COG2995	paraquat-inducible protein a
CH48_83	COG0488	(ABC) transporter
CH48_831	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CH48_832	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH48_833	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH48_834	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH48_835	COG4974	Belongs to the 'phage' integrase family
CH48_836	COG0716	FMN binding
CH48_837	COG4452	Inner membrane protein CreD
CH48_838	COG2205	protein histidine kinase activity
CH48_839	COG0745	RESPONSE REGULATOR receiver
CH48_84	COG0116	Belongs to the methyltransferase superfamily
CH48_84	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH48_841	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH48_842	COG0354	folic acid binding
CH48_844	COG1272	protein, Hemolysin III
CH48_846	COG1028	Short-chain dehydrogenase reductase Sdr
CH48_849	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH48_849	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH48_85	COG3217	Mosc domain protein beta barrel domain protein
CH48_85	COG0633	Ferredoxin
CH48_850	COG0509	glycine decarboxylation via glycine cleavage system
CH48_851	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH48_852	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH48_853	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH48_854	COG0006	proline dipeptidase activity
CH48_855	COG3079	Belongs to the UPF0149 family
CH48_856	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH48_857	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH48_858	COG0148	phosphopyruvate hydratase activity
CH48_859	COG0504	CTP synthase activity
CH48_861	COG3956	TIGRFAM MazG family protein
CH48_862	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH48_863	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH48_864	COG3437	response regulator, receiver
CH48_864	COG2205	protein histidine kinase activity
CH48_864	COG3850	Histidine kinase
CH48_864	COG4999	Histidine kinase
CH48_865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH48_866	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH48_867	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH48_869	COG2860	membrane
CH48_87	COG0167	dihydroorotate dehydrogenase activity
CH48_870	COG0316	Belongs to the HesB IscA family
CH48_872	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH48_873	COG2223	nitrite transmembrane transporter activity
CH48_874	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH48_876	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH48_877	COG1120	ATPase activity
CH48_878	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH48_879	COG1643	Atp-dependent helicase
CH48_88	COG0308	aminopeptidase N
CH48_880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH48_881	COG1489	DNA binding
CH48_882	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH48_885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH48_886	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH48_887	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH48_888	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH48_889	COG0726	polysaccharide deacetylase
CH48_89	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH48_890	COG0842	Transport permease protein
CH48_891	COG1131	(ABC) transporter
CH48_893	COG0288	reversible hydration of carbon dioxide
CH48_894	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH48_895	COG2132	Multicopper oxidase
CH48_897	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH48_898	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH48_9	COG1399	metal-binding, possibly nucleic acid-binding protein
CH48_90	COG0017	Asparaginyl-tRNA synthetase
CH48_900	COG0697	spore germination
CH48_901	COG3112	Uncharacterised protein family (UPF0231)
CH48_904	COG4977	sequence-specific DNA binding
CH48_906	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH48_907	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH48_908	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH48_909	COG2186	Transcriptional regulator
CH48_910	COG1113	amino acid transport
CH48_911	COG3725	Membrane protein required for beta-lactamase induction
CH48_914	COG4969	Belongs to the N-Me-Phe pilin family
CH48_915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH48_916	COG1459	type II secretion system
CH48_917	COG0516	GMP reductase activity
CH48_918	COG0237	dephospho-CoA kinase activity
CH48_92	COG1448	Aminotransferase
CH48_920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH48_921	COG0494	nUDIX hydrolase
CH48_922	COG0653	protein targeting
CH48_926	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH48_927	COG0849	cell division
CH48_928	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH48_93	COG2200	EAL domain
CH48_930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH48_931	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH48_932	COG0772	Belongs to the SEDS family
CH48_934	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH48_935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH48_936	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH48_937	COG0768	penicillin binding
CH48_938	COG3116	cell division
CH48_939	COG0275	rRNA processing
CH48_94	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH48_940	COG2001	Belongs to the MraZ family
CH48_942	COG1609	Transcriptional regulator
CH48_944	COG0028	Belongs to the TPP enzyme family
CH48_945	COG1022	Amp-dependent synthetase and ligase
CH48_948	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH48_949	COG0473	3-isopropylmalate dehydrogenase activity
CH48_95	COG3108	Peptidase M15
CH48_950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH48_953	COG3033	Beta-eliminating lyase
CH48_954	COG0814	amino acid
CH48_956	COG2814	Major facilitator Superfamily
CH48_958	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH48_959	COG4533	DNA binding
CH48_96	COG2989	Protein conserved in bacteria
CH48_962	COG4143	(ABC) transporter
CH48_963	COG1178	ABC-type Fe3 transport system permease component
CH48_964	COG0586	Pfam SNARE associated Golgi protein
CH48_966	COG0417	DNA replication proofreading
CH48_967	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH48_968	COG1470	cell adhesion involved in biofilm formation
CH48_968	COG1388	LysM domain
CH48_969	COG0564	pseudouridine synthase activity
CH48_97	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH48_970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH48_971	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH48_972	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH48_974	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH48_975	COG2967	ApaG domain
CH48_976	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH48_977	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH48_978	COG3610	response to peptide
CH48_979	COG2966	Psort location CytoplasmicMembrane, score
CH48_98	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH48_980	COG1280	lysine exporter protein (LysE YggA)
CH48_981	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH48_982	COG0505	Belongs to the CarA family
CH48_983	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH48_984	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH48_985	COG1047	Peptidyl-prolyl cis-trans
CH48_986	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH48_987	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH48_988	COG0196	riboflavin kinase activity
CH48_989	COG0268	Binds directly to 16S ribosomal RNA
CH48_99	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH48_990	COG0583	DNA-binding transcription factor activity
CH48_991	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH48_992	COG0484	heat shock protein binding
CH48_993	COG0443	Heat shock 70 kDa protein
CH48_994	COG1584	GPR1 FUN34 yaaH family protein
CH48_998	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH48_999	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway