locus-tag	class	description
I6I39_00010	COG1338	Plays a role in the flagellum-specific transport system
I6I39_00030	COG1256	bacterial-type flagellum assembly
I6I39_00065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I39_00070	COG1558	bacterial-type flagellum-dependent cell motility
I6I39_00075	COG1815	bacterial-type flagellum-dependent cell motility
I6I39_00085	COG2747	anti-sigma28 factor FlgM
I6I39_00090	COG3418	PFAM FlgN family protein
I6I39_00110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I39_00115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I39_00120	COG1404	Belongs to the peptidase S8 family
I6I39_00120	COG4935	Belongs to the peptidase S8 family
I6I39_00125	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I39_00130	COG0745	RESPONSE REGULATOR receiver
I6I39_00140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I39_00145	COG0840	transmembrane signaling receptor activity
I6I39_00150	COG0840	transmembrane signaling receptor activity
I6I39_00155	COG0835	chemotaxis
I6I39_00160	COG0643	Histidine kinase
I6I39_00160	COG2198	Histidine kinase
I6I39_00165	COG1360	Flagellar Motor Protein
I6I39_00185	COG0589	response to stress
I6I39_00190	COG2130	NADP-dependent
I6I39_00200	COG1285	pathogenesis
I6I39_00215	COG0840	transmembrane signaling receptor activity
I6I39_00230	COG1609	Transcriptional regulator
I6I39_00235	COG3250	beta-galactosidase activity
I6I39_00240	COG3328	transposase activity
I6I39_00245	COG3321	synthase
I6I39_00245	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_00245	COG0604	alcohol dehydrogenase
I6I39_00280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I39_00290	COG3263	regulation of cellular component size
I6I39_00300	COG3916	Acyl-homoserine-lactone synthase
I6I39_00305	COG2771	luxR family
I6I39_00310	COG4235	cytochrome complex assembly
I6I39_00315	COG3088	subunit of a heme lyase
I6I39_00320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I39_00325	COG1138	Cytochrome C-type biogenesis protein
I6I39_00330	COG3301	Polysulphide reductase, NrfD
I6I39_00335	COG0437	4 iron, 4 sulfur cluster binding
I6I39_00340	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6I39_00355	COG2920	part of a sulfur-relay system
I6I39_00360	COG1254	Belongs to the acylphosphatase family
I6I39_00375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I39_00380	COG3785	DNA binding
I6I39_00385	COG1832	CoA-binding protein
I6I39_00395	COG1803	Methylglyoxal synthase
I6I39_00400	COG0210	DNA helicase
I6I39_00405	COG3304	Inner membrane component domain
I6I39_00410	COG1289	transmembrane transporter activity
I6I39_00415	COG3070	regulator of competence-specific genes
I6I39_00420	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6I39_00430	COG3120	sequence-specific DNA binding
I6I39_00435	COG1067	ATP-dependent peptidase activity
I6I39_00440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I39_00450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I39_00455	COG3130	regulation of translation
I6I39_00460	COG3009	Protein conserved in bacteria
I6I39_00465	COG3008	intermembrane lipid transfer
I6I39_00465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I39_00470	COG2995	paraquat-inducible protein a
I6I39_00475	COG0488	(ABC) transporter
I6I39_00480	COG0116	Belongs to the methyltransferase superfamily
I6I39_00480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I39_00485	COG0633	Ferredoxin
I6I39_00485	COG3217	Mosc domain protein beta barrel domain protein
I6I39_00495	COG0167	dihydroorotate dehydrogenase activity
I6I39_00500	COG0308	aminopeptidase N
I6I39_00505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I39_00510	COG0017	Asparaginyl-tRNA synthetase
I6I39_00520	COG1448	Aminotransferase
I6I39_00525	COG2200	EAL domain
I6I39_00530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I39_00535	COG3108	Peptidase M15
I6I39_00540	COG2989	Protein conserved in bacteria
I6I39_00545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I39_00555	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6I39_00560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I39_00565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I39_00570	COG3173	Aminoglycoside phosphotransferase
I6I39_00575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I39_00580	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I39_00585	COG1278	Cold shock
I6I39_00595	COG5383	Protein conserved in bacteria
I6I39_00600	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I39_00610	COG0658	competence protein
I6I39_00610	COG2333	competence protein COMEC
I6I39_00615	COG0776	regulation of translation
I6I39_00620	COG0539	negative regulation of cytoplasmic translation
I6I39_00625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I39_00630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I39_00635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I39_00640	COG2323	membrane
I6I39_00645	COG0252	asparaginase activity
I6I39_00650	COG1944	ATP diphosphatase activity
I6I39_00660	COG2116	formate transmembrane transporter activity
I6I39_00665	COG1882	Formate acetyltransferase
I6I39_00670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I39_00675	COG2814	Major facilitator Superfamily
I6I39_00680	COG3328	transposase activity
I6I39_00690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I39_00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I39_00700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I39_00705	COG1674	ftsk spoiiie
I6I39_00705	COG3107	peptidoglycan biosynthetic process
I6I39_00710	COG1522	sequence-specific DNA binding
I6I39_00715	COG0492	ferredoxin-NADP+ reductase activity
I6I39_00725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I39_00730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I39_00735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I39_00740	COG0542	response to heat
I6I39_00745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I39_00750	COG1278	Cold shock
I6I39_00760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_00765	COG2990	Protein conserved in bacteria
I6I39_00770	COG3593	DNA synthesis involved in DNA repair
I6I39_00775	COG2431	L-lysine efflux transmembrane transporter activity
I6I39_00780	COG1151	hydroxylamine reductase activity
I6I39_00785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I39_00790	COG0028	Belongs to the TPP enzyme family
I6I39_00800	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I39_00805	COG0702	epimerase
I6I39_00810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_00820	COG1126	abc transporter atp-binding protein
I6I39_00825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_00830	COG4215	(ABC) transporter
I6I39_00835	COG4160	amino acid transport
I6I39_00840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_00845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I39_00855	COG1177	transmembrane transport
I6I39_00860	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I39_00865	COG3842	ATPase activity
I6I39_00870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I39_00890	COG0569	domain protein
I6I39_00890	COG2985	domain, Protein
I6I39_00900	COG0671	phosphoesterase, PA-phosphatase related
I6I39_00905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I39_00910	COG1349	DNA-binding transcription factor activity
I6I39_00915	COG0814	amino acid
I6I39_00920	COG1760	l-serine dehydratase
I6I39_00930	COG1686	Belongs to the peptidase S11 family
I6I39_00940	COG0626	cystathionine gamma-synthase activity
I6I39_00945	COG2011	ABC-type metal ion transport system permease component
I6I39_00970	COG0625	glutathione transferase activity
I6I39_00975	COG4771	TonB-dependent receptor
I6I39_00985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I39_00990	COG0833	amino acid
I6I39_00995	COG0583	DNA-binding transcription factor activity
I6I39_01005	COG2855	membrane
I6I39_01010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I39_01035	COG3710	Transcriptional regulator
I6I39_01040	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I39_01040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I39_01040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I39_01045	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I39_01060	COG3005	denitrification pathway
I6I39_01065	COG0243	molybdopterin cofactor binding
I6I39_01080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I39_01085	COG1312	Catalyzes the dehydration of D-mannonate
I6I39_01095	COG0246	Mannitol dehydrogenase
I6I39_01100	COG2186	Transcriptional regulator
I6I39_01110	COG0523	cobalamin synthesis protein
I6I39_01115	COG0671	phosphoesterase, PA-phosphatase related
I6I39_01120	COG0791	NLP P60 protein
I6I39_01125	COG2200	EAL domain
I6I39_01130	COG4166	transmembrane transport
I6I39_01135	COG4174	ABC transporter (Permease)
I6I39_01140	COG4239	(ABC) transporter, permease
I6I39_01145	COG4172	Belongs to the ABC transporter superfamily
I6I39_01155	COG2814	Major facilitator Superfamily
I6I39_01160	COG1187	pseudouridine synthase activity
I6I39_01165	COG1061	Type III restriction enzyme res subunit
I6I39_01170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I39_01175	COG3081	Nucleoid-associated protein
I6I39_01180	COG3082	Protein of unknown function (DUF1414)
I6I39_01205	COG3328	transposase activity
I6I39_01215	COG2723	6-phospho-beta-galactosidase activity
I6I39_01220	COG1263	PTS System
I6I39_01220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_01220	COG2190	(PTS) system
I6I39_01225	COG1737	Transcriptional regulator
I6I39_01275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I39_01290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I39_01300	COG2223	nitrite transmembrane transporter activity
I6I39_01305	COG0642	Histidine kinase
I6I39_01305	COG2198	Histidine kinase
I6I39_01310	COG2197	response regulator
I6I39_01315	COG0784	Response regulator, receiver
I6I39_01315	COG2205	protein histidine kinase activity
I6I39_01325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I39_01330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I39_01340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I39_01345	COG4574	serine-type endopeptidase inhibitor activity
I6I39_01365	COG0814	amino acid
I6I39_01385	COG1441	menaquinone biosynthetic process
I6I39_01390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I39_01395	COG0596	Alpha beta hydrolase
I6I39_01400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I39_01405	COG1169	isochorismate synthase
I6I39_01410	COG4575	ribosome binding
I6I39_01415	COG0129	dihydroxy-acid dehydratase activity
I6I39_01420	COG4702	Belongs to the UPF0303 family
I6I39_01430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I39_01435	COG1609	Transcriptional regulator
I6I39_01440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_01445	COG3265	gluconokinase activity
I6I39_01465	COG1007	ATP synthesis coupled electron transport
I6I39_01470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_01475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I39_01480	COG0713	ATP synthesis coupled electron transport
I6I39_01485	COG0839	Belongs to the complex I subunit 6 family
I6I39_01490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_01495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I39_01500	COG1034	ATP synthesis coupled electron transport
I6I39_01515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_01515	COG0649	NAD binding
I6I39_01520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_01525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_01530	COG0583	DNA-binding transcription factor activity
I6I39_01535	COG0436	Aminotransferase
I6I39_01540	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I39_01545	COG0490	domain, Protein
I6I39_01545	COG0471	metal ion transport
I6I39_01555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_01560	COG3013	Belongs to the UPF0304 family
I6I39_01565	COG3092	negative regulation of chromosome organization
I6I39_01575	COG0857	belongs to the CobB CobQ family
I6I39_01575	COG0280	phosphate acetyltransferase
I6I39_01580	COG1609	Transcriptional regulator
I6I39_01585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_01595	COG3037	sugar-specific permease SgaT UlaA
I6I39_01610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I39_01615	COG0622	Phosphoesterase
I6I39_01625	COG1090	epimerase
I6I39_01640	COG4598	ABC transporter
I6I39_01645	COG4160	amino acid transport
I6I39_01650	COG4215	(ABC) transporter
I6I39_01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_01660	COG0163	prenyltransferase activity
I6I39_01665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I39_01670	COG1286	toxin biosynthetic process
I6I39_01675	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6I39_01680	COG0285	dihydrofolate synthase activity
I6I39_01685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I39_01690	COG0586	Pfam SNARE associated Golgi protein
I6I39_01700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I39_01705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I39_01715	COG0697	spore germination
I6I39_01720	COG0697	spore germination
I6I39_01730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_01735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I39_01760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I39_01770	COG1609	Transcriptional regulator
I6I39_01780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_01785	COG2723	6-phospho-beta-galactosidase activity
I6I39_01790	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I39_01800	COG1794	racemase activity, acting on amino acids and derivatives
I6I39_01810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I39_01815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I39_01815	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I39_01825	COG3101	peptidyl-lysine hydroxylation
I6I39_01830	COG0730	response to heat
I6I39_01835	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6I39_01840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I39_01845	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I39_01850	COG2840	Smr protein MutS2
I6I39_01855	COG2062	phosphohistidine phosphatase, SixA
I6I39_01860	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I39_01860	COG1024	Enoyl-CoA hydratase
I6I39_01865	COG0183	Belongs to the thiolase family
I6I39_01870	COG3691	Protein conserved in bacteria
I6I39_01885	COG3088	subunit of a heme lyase
I6I39_01885	COG4235	cytochrome complex assembly
I6I39_01895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I39_01900	COG1138	Cytochrome C-type biogenesis protein
I6I39_01905	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I39_01910	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I39_01915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I39_01920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I39_01930	COG2116	formate transmembrane transporter activity
I6I39_01950	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I39_01955	COG1695	Transcriptional regulator
I6I39_01965	COG2723	6-phospho-beta-galactosidase activity
I6I39_01970	COG1263	PTS System
I6I39_01970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_01975	COG1609	Transcriptional regulator
I6I39_01980	COG2353	YceI-like domain
I6I39_01985	COG3038	cytochrome b561
I6I39_01990	COG0657	acetylesterase activity
I6I39_01990	COG2755	lipolytic protein G-D-S-L family
I6I39_02010	COG1127	ABC transporter
I6I39_02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I39_02035	COG0531	amino acid
I6I39_02040	COG2951	lytic endotransglycosylase activity
I6I39_02060	COG1280	lysine exporter protein (LysE YggA)
I6I39_02070	COG1598	PFAM Uncharacterised protein family UPF0150
I6I39_02080	COG3038	cytochrome b561
I6I39_02085	COG0436	Aminotransferase
I6I39_02100	COG3275	phosphorelay sensor kinase activity
I6I39_02105	COG3279	Response regulator of the LytR AlgR family
I6I39_02110	COG2223	nitrite transmembrane transporter activity
I6I39_02115	COG0837	glucose binding
I6I39_02130	COG3961	Belongs to the TPP enzyme family
I6I39_02135	COG0667	Aldo Keto reductase
I6I39_02145	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I39_02150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I39_02175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I39_02200	COG3530	Putative quorum-sensing-regulated virulence factor
I6I39_02205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I39_02225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_02230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I39_02240	COG2205	protein histidine kinase activity
I6I39_02245	COG0745	RESPONSE REGULATOR receiver
I6I39_02250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_02270	COG4208	sulfate ABC transporter
I6I39_02275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I39_02280	COG4150	thiosulfate binding
I6I39_02290	COG1737	Transcriptional regulator
I6I39_02295	COG2731	YhcH YjgK YiaL family protein
I6I39_02310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I39_02320	COG2837	iron assimilation
I6I39_02330	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I39_02335	COG0456	acetyltransferase
I6I39_02340	COG0408	coproporphyrinogen oxidase activity
I6I39_02345	COG1671	Belongs to the UPF0178 family
I6I39_02365	COG0280	phosphate acetyltransferase
I6I39_02365	COG0281	malic enzyme
I6I39_02370	COG0494	nUDIX hydrolase
I6I39_02375	COG3005	denitrification pathway
I6I39_02380	COG3043	anaerobic respiration
I6I39_02385	COG0243	molybdopterin cofactor binding
I6I39_02390	COG3062	negative regulation of establishment of protein localization
I6I39_02400	COG2197	response regulator
I6I39_02410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_02425	COG1393	Belongs to the ArsC family
I6I39_02430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I39_02435	COG1876	peptidase activity
I6I39_02480	COG0400	carboxylic ester hydrolase activity
I6I39_02490	COG1444	tRNA N-acetyltransferase activity
I6I39_02495	COG2707	UPF0756 membrane protein
I6I39_02500	COG2321	neutral zinc metallopeptidase
I6I39_02505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I39_02510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I39_02515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I39_02520	COG2716	regulation of RNA biosynthetic process
I6I39_02525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I39_02530	COG0628	permease
I6I39_02535	COG4783	chaperone-mediated protein folding
I6I39_02540	COG1393	Belongs to the ArsC family
I6I39_02545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I39_02550	COG2233	PERMEase
I6I39_02555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I39_02560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I39_02565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I39_02570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I39_02575	COG3447	MASE1 domain protein
I6I39_02575	COG5002	protein histidine kinase activity
I6I39_02575	COG5001	Diguanylate cyclase
I6I39_02580	COG2239	Acts as a magnesium transporter
I6I39_02595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I39_02600	COG0573	inorganic phosphate transmembrane transporter activity
I6I39_02605	COG0581	inorganic phosphate transmembrane transporter activity
I6I39_02615	COG5002	protein histidine kinase activity
I6I39_02615	COG5001	Diguanylate cyclase
I6I39_02615	COG3447	MASE1 domain protein
I6I39_02620	COG0443	Heat shock 70 kDa protein
I6I39_02630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_02640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_02645	COG0477	Major facilitator Superfamily
I6I39_02650	COG2205	protein histidine kinase activity
I6I39_02655	COG0745	RESPONSE REGULATOR receiver
I6I39_02660	COG3422	double-strand break repair
I6I39_02665	COG0826	peptidase U32
I6I39_02670	COG1597	lipid kinase activity
I6I39_02675	COG3730	PTS system glucitol sorbitol-specific
I6I39_02690	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_02695	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_02700	COG1349	DNA-binding transcription factor activity
I6I39_02720	COG0351	phosphomethylpyrimidine kinase
I6I39_02755	COG0519	Catalyzes the synthesis of GMP from XMP
I6I39_02755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I39_02760	COG0516	GMP reductase activity
I6I39_02760	COG0517	IMP dehydrogenase activity
I6I39_02765	COG1570	exodeoxyribonuclease VII activity
I6I39_02770	COG1645	bacterial-type flagellum-dependent swarming motility
I6I39_02780	COG1160	GTP binding
I6I39_02785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I39_02790	COG2976	Protein conserved in bacteria
I6I39_02795	COG0124	histidyl-tRNA synthetase
I6I39_02800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I39_02805	COG1426	Protein conserved in bacteria
I6I39_02815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I39_02830	COG4953	penicillin-binding protein 1C
I6I39_02835	COG2373	Large extracellular alpha-helical protein
I6I39_02845	COG3468	outer membrane autotransporter barrel domain protein
I6I39_02860	COG2975	iron-sulfur cluster assembly
I6I39_02865	COG0633	Ferredoxin
I6I39_02870	COG0443	Heat shock 70 kDa protein
I6I39_02875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I39_02880	COG0316	Belongs to the HesB IscA family
I6I39_02885	COG0822	iron-sulfur transferase activity
I6I39_02895	COG1959	2 iron, 2 sulfur cluster binding
I6I39_02900	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6I39_02910	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I39_02915	COG3683	transport system, periplasmic component
I6I39_02920	COG3711	transcriptional antiterminator
I6I39_02925	COG2814	Major facilitator Superfamily
I6I39_02930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I39_02935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I39_02935	COG1017	nitric oxide dioxygenase activity
I6I39_02940	COG2188	Transcriptional regulator
I6I39_02950	COG3457	Alanine racemase
I6I39_02955	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6I39_02970	COG0347	Belongs to the P(II) protein family
I6I39_02975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I39_02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I39_02980	COG2204	response regulator
I6I39_02985	COG3170	Tfp pilus assembly protein FimV
I6I39_02990	COG2205	protein histidine kinase activity
I6I39_03005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I39_03020	COG0560	Phosphoserine phosphatase
I6I39_03030	COG1737	Transcriptional regulator
I6I39_03035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I39_03040	COG2610	gluconate transmembrane transporter activity
I6I39_03045	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I39_03050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I39_03055	COG1381	Involved in DNA repair and RecF pathway recombination
I6I39_03060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I39_03065	COG0571	ribonuclease III activity
I6I39_03075	COG0481	GTPase activity
I6I39_03085	COG3086	response to oxidative stress
I6I39_03095	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6I39_03105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I39_03110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I39_03115	COG0513	Belongs to the DEAD box helicase family
I6I39_03140	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6I39_03145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I39_03150	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I39_03155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I39_03160	COG0497	DNA recombination
I6I39_03165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I39_03175	COG2867	negative regulation of translational initiation
I6I39_03180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I39_03190	COG0582	viral genome integration into host DNA
I6I39_03195	COG3328	transposase activity
I6I39_03200	COG0659	secondary active sulfate transmembrane transporter activity
I6I39_03205	COG3394	polysaccharide catabolic process
I6I39_03210	COG1917	Cupin 2, conserved barrel domain protein
I6I39_03210	COG2169	Transcriptional regulator
I6I39_03215	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I39_03220	COG2723	6-phospho-beta-galactosidase activity
I6I39_03225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_03230	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_03235	COG2133	pyrroloquinoline quinone binding
I6I39_03245	COG0667	Aldo Keto reductase
I6I39_03260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I39_03270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I39_03275	COG4413	Urea transporter
I6I39_03280	COG0829	nickel cation binding
I6I39_03285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I39_03290	COG0830	nickel cation binding
I6I39_03295	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I39_03300	COG0804	urea catabolic process
I6I39_03305	COG0832	Belongs to the urease beta subunit family
I6I39_03310	COG0831	urea catabolic process
I6I39_03315	COG1124	(ABC) transporter
I6I39_03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_03360	COG1278	Cold shock
I6I39_03385	COG2207	Transcriptional regulator
I6I39_03400	COG4575	ribosome binding
I6I39_03410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I39_03420	COG1780	Probably involved in ribonucleotide reductase function
I6I39_03430	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I39_03440	COG4176	ABC-type proline glycine betaine transport system permease component
I6I39_03445	COG2113	Glycine betaine
I6I39_03460	COG0328	RNA-DNA hybrid ribonuclease activity
I6I39_03465	COG2226	methyltransferase
I6I39_03470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I39_03475	COG1388	LysM domain
I6I39_03475	COG0741	lytic transglycosylase activity
I6I39_03485	COG3021	interspecies interaction between organisms
I6I39_03490	COG2814	Major facilitator Superfamily
I6I39_03495	COG0583	DNA-binding transcription factor activity
I6I39_03500	COG0656	L-ascorbic acid biosynthetic process
I6I39_03510	COG3328	transposase activity
I6I39_03540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I39_03550	COG2011	ABC-type metal ion transport system permease component
I6I39_03555	COG1464	Belongs to the NlpA lipoprotein family
I6I39_03565	COG1720	tRNA m6t6A37 methyltransferase activity
I6I39_03570	COG0442	prolyl-tRNA aminoacylation
I6I39_03575	COG3015	lipoprotein NlpE involved in copper resistance
I6I39_03585	COG4681	YaeQ
I6I39_03595	COG4568	rho-dependent transcription termination
I6I39_03610	COG0346	lactoylglutathione lyase activity
I6I39_03615	COG1982	Orn Lys Arg decarboxylase major
I6I39_03620	COG0825	malonyl-CoA metabolic process
I6I39_03630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I39_03640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I39_03645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I39_03650	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I39_03655	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I39_03665	COG0750	zinc metalloprotease
I6I39_03670	COG0575	Belongs to the CDS family
I6I39_03680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I39_03685	COG0233	cytoplasmic translational termination
I6I39_03690	COG0528	UMP kinase activity
I6I39_03695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I39_03700	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I39_03710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I39_03715	COG2171	N-acyltransferase activity
I6I39_03730	COG0564	pseudouridine synthase activity
I6I39_03735	COG3098	single-species biofilm formation
I6I39_03745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I39_03745	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I39_03750	COG1611	Belongs to the LOG family
I6I39_03755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I39_03760	COG3328	transposase activity
I6I39_03770	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I39_03775	COG2363	Small membrane protein
I6I39_03780	COG0583	DNA-binding transcription factor activity
I6I39_03790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I39_03795	COG2166	iron-sulfur cluster assembly
I6I39_03800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I39_03805	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I39_03820	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I39_03825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I39_03825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I39_03835	COG0484	heat shock protein binding
I6I39_03845	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_03850	COG1733	regulation of RNA biosynthetic process
I6I39_03855	COG0288	reversible hydration of carbon dioxide
I6I39_03880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I39_03890	COG2165	general secretion pathway protein
I6I39_03915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I39_03955	COG2814	Major facilitator Superfamily
I6I39_03960	COG0583	DNA-binding transcription factor activity
I6I39_03970	COG1609	Transcriptional regulator
I6I39_03985	COG0318	PFAM AMP-dependent synthetase and ligase
I6I39_03985	COG0204	Acyl-transferase
I6I39_03990	COG0477	Major facilitator Superfamily
I6I39_03995	COG0667	Aldo Keto reductase
I6I39_04000	COG0861	Integral membrane protein TerC family
I6I39_04005	COG3066	DNA modification
I6I39_04010	COG1051	belongs to the nudix hydrolase family
I6I39_04020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I39_04025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I39_04030	COG2165	general secretion pathway protein
I6I39_04045	COG4967	type IV pilus modification protein PilV
I6I39_04050	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I39_04055	COG1025	Belongs to the peptidase M16 family
I6I39_04060	COG1074	ATP-dependent DNA helicase activity
I6I39_04065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I39_04075	COG3706	GGDEF domain
I6I39_04080	COG4319	ketosteroid isomerase
I6I39_04095	COG3328	transposase activity
I6I39_04100	COG2944	sequence-specific DNA binding
I6I39_04125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I39_04135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I39_04140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I39_04145	COG4974	Belongs to the 'phage' integrase family
I6I39_04150	COG0716	FMN binding
I6I39_04155	COG4452	Inner membrane protein CreD
I6I39_04165	COG0745	RESPONSE REGULATOR receiver
I6I39_04180	COG0354	folic acid binding
I6I39_04190	COG1272	protein, Hemolysin III
I6I39_04200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_04210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I39_04210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I39_04215	COG0509	glycine decarboxylation via glycine cleavage system
I6I39_04220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I39_04225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I39_04230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I39_04235	COG0006	proline dipeptidase activity
I6I39_04240	COG3079	Belongs to the UPF0149 family
I6I39_04245	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I39_04255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I39_04260	COG0148	phosphopyruvate hydratase activity
I6I39_04265	COG0504	CTP synthase activity
I6I39_04270	COG3956	TIGRFAM MazG family protein
I6I39_04275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I39_04280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I39_04285	COG2205	protein histidine kinase activity
I6I39_04285	COG4999	Histidine kinase
I6I39_04285	COG3850	Histidine kinase
I6I39_04285	COG3437	response regulator, receiver
I6I39_04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I39_04295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I39_04300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I39_04310	COG2860	membrane
I6I39_04315	COG0316	Belongs to the HesB IscA family
I6I39_04325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I39_04330	COG2223	nitrite transmembrane transporter activity
I6I39_04335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I39_04340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I39_04345	COG1120	ATPase activity
I6I39_04350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I39_04355	COG1643	Atp-dependent helicase
I6I39_04360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I39_04365	COG1489	DNA binding
I6I39_04385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I39_04390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I39_04395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I39_04400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I39_04405	COG0726	polysaccharide deacetylase
I6I39_04410	COG0842	Transport permease protein
I6I39_04415	COG1131	(ABC) transporter
I6I39_04420	COG0288	reversible hydration of carbon dioxide
I6I39_04430	COG2132	Multicopper oxidase
I6I39_04440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I39_04445	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I39_04460	COG3112	Uncharacterised protein family (UPF0231)
I6I39_04475	COG4977	sequence-specific DNA binding
I6I39_04485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_04490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I39_04495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I39_04500	COG2186	Transcriptional regulator
I6I39_04505	COG1113	amino acid transport
I6I39_04510	COG3725	Membrane protein required for beta-lactamase induction
I6I39_04525	COG4969	Belongs to the N-Me-Phe pilin family
I6I39_04530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I39_04535	COG1459	type II secretion system
I6I39_04540	COG0516	GMP reductase activity
I6I39_04555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I39_04560	COG0494	nUDIX hydrolase
I6I39_04565	COG0653	protein targeting
I6I39_04585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I39_04590	COG0849	cell division
I6I39_04595	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I39_04605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I39_04610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I39_04615	COG0772	Belongs to the SEDS family
I6I39_04625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I39_04630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I39_04635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I39_04640	COG0768	penicillin binding
I6I39_04645	COG3116	cell division
I6I39_04650	COG0275	rRNA processing
I6I39_04655	COG2001	Belongs to the MraZ family
I6I39_04675	COG0028	Belongs to the TPP enzyme family
I6I39_04680	COG1022	Amp-dependent synthetase and ligase
I6I39_04695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I39_04700	COG0473	3-isopropylmalate dehydrogenase activity
I6I39_04705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I39_04725	COG0814	amino acid
I6I39_04730	COG2814	Major facilitator Superfamily
I6I39_04735	COG1882	Formate acetyltransferase
I6I39_04740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I39_04745	COG4533	DNA binding
I6I39_04760	COG4143	(ABC) transporter
I6I39_04765	COG1178	ABC-type Fe3 transport system permease component
I6I39_04775	COG0586	Pfam SNARE associated Golgi protein
I6I39_04780	COG0417	DNA replication proofreading
I6I39_04785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I39_04790	COG1470	cell adhesion involved in biofilm formation
I6I39_04790	COG1388	LysM domain
I6I39_04795	COG0564	pseudouridine synthase activity
I6I39_04800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I39_04805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I39_04820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I39_04825	COG2967	ApaG domain
I6I39_04830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I39_04835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I39_04840	COG3610	response to peptide
I6I39_04845	COG2966	Psort location CytoplasmicMembrane, score
I6I39_04850	COG1280	lysine exporter protein (LysE YggA)
I6I39_04855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I39_04865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I39_04870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I39_04875	COG1047	Peptidyl-prolyl cis-trans
I6I39_04880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I39_04885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I39_04890	COG0196	riboflavin kinase activity
I6I39_04895	COG0268	Binds directly to 16S ribosomal RNA
I6I39_04900	COG0583	DNA-binding transcription factor activity
I6I39_04905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I39_04910	COG0484	heat shock protein binding
I6I39_04915	COG0443	Heat shock 70 kDa protein
I6I39_04920	COG1584	GPR1 FUN34 yaaH family protein
I6I39_04935	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I39_04940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I39_04945	COG3022	response to hydroperoxide
I6I39_04960	COG0083	homoserine kinase activity
I6I39_04975	COG0745	RESPONSE REGULATOR receiver
I6I39_04980	COG3045	CreA protein
I6I39_04985	COG2207	Transcriptional regulator
I6I39_04985	COG3708	Transcriptional regulator
I6I39_04990	COG0406	alpha-ribazole phosphatase activity
I6I39_04995	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6I39_05000	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6I39_05005	COG0741	lytic transglycosylase activity
I6I39_05010	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I39_05020	COG2199	diguanylate cyclase activity
I6I39_05025	COG2885	chlorophyll binding
I6I39_05030	COG0488	(ABC) transporter
I6I39_05045	COG0604	alcohol dehydrogenase
I6I39_05070	COG0560	Phosphoserine phosphatase
I6I39_05075	COG3726	membrane protein affecting hemolysin expression
I6I39_05080	COG0813	purine-nucleoside phosphorylase activity
I6I39_05085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I39_05090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I39_05100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I39_05105	COG0084	hydrolase, TatD family'
I6I39_05110	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I39_05120	COG2823	Periplasmic or secreted lipoprotein
I6I39_05125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I39_05130	COG0456	acetyltransferase
I6I39_05135	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6I39_05140	COG2813	Specifically methylates the guanine in position
I6I39_05145	COG0667	Aldo Keto reductase
I6I39_05150	COG0583	DNA-binding transcription factor activity
I6I39_05175	COG4772	TonB-dependent receptor
I6I39_05210	COG3284	Transcriptional regulator
I6I39_05240	COG2192	nodulation
I6I39_05250	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I39_05250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_05250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I39_05255	COG1461	Dihydroxyacetone kinase
I6I39_05260	COG2376	Dihydroxyacetone kinase
I6I39_05270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_05275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_05280	COG2235	arginine
I6I39_05295	COG0859	PFAM glycosyl transferase family 9
I6I39_05300	COG1070	Carbohydrate kinase
I6I39_05305	COG2390	Transcriptional regulator
I6I39_05315	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_05320	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_05325	COG1879	ABC-type sugar transport system periplasmic component
I6I39_05330	COG1830	Aldolase
I6I39_05335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I39_05380	COG0454	-acetyltransferase
I6I39_05435	COG0795	lipopolysaccharide-transporting ATPase activity
I6I39_05440	COG0795	lipopolysaccharide-transporting ATPase activity
I6I39_05445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I39_05450	COG2927	DNA polymerase III (CHI subunit)
I6I39_05470	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6I39_05480	COG2731	YhcH YjgK YiaL family protein
I6I39_05490	COG0601	transmembrane transport
I6I39_05495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_05500	COG0444	Belongs to the ABC transporter superfamily
I6I39_05505	COG4608	Belongs to the ABC transporter superfamily
I6I39_05535	COG2188	Transcriptional regulator
I6I39_05540	COG3624	Phosphonate C-P lyase system protein PhnG
I6I39_05545	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I39_05555	COG3627	carbon phosphorus lyase activity
I6I39_05560	COG4107	phosphonate C-P lyase system protein PhnK
I6I39_05565	COG4778	phosphonate C-P lyase system protein PhnL
I6I39_05570	COG3454	Phosphonate metabolism
I6I39_05580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I39_05585	COG0702	epimerase
I6I39_05600	COG3787	Belongs to the UPF0306 family
I6I39_05610	COG3842	ATPase activity
I6I39_05615	COG0395	ABC-type sugar transport system, permease component
I6I39_05620	COG1175	transmembrane transport
I6I39_05625	COG1653	transport
I6I39_05645	COG1982	Orn Lys Arg decarboxylase major
I6I39_05650	COG0531	amino acid
I6I39_05655	COG2827	Endonuclease containing a URI domain
I6I39_05660	COG3153	acetyltransferase
I6I39_05665	COG3154	lipid carrier protein
I6I39_05670	COG0826	peptidase U32
I6I39_05675	COG0826	peptidase U32
I6I39_05680	COG3681	Belongs to the UPF0597 family
I6I39_05685	COG0814	amino acid
I6I39_05695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I39_05705	COG0513	Belongs to the DEAD box helicase family
I6I39_05720	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I39_05725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I39_05730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I39_05735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I39_05740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I39_05745	COG0195	Participates in both transcription termination and antitermination
I6I39_05750	COG0779	Required for maturation of 30S ribosomal subunits
I6I39_05765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I39_05770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I39_05775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I39_05785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I39_05790	COG1534	Rna-binding protein
I6I39_05800	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I39_05805	COG0745	RESPONSE REGULATOR receiver
I6I39_05810	COG0642	Histidine kinase
I6I39_05815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I39_05820	COG0697	spore germination
I6I39_05825	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I39_05830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I39_05835	COG0142	geranyltranstransferase activity
I6I39_05845	COG3423	Transcriptional regulator
I6I39_05850	COG0039	L-malate dehydrogenase activity
I6I39_05855	COG1438	arginine binding
I6I39_05865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I39_05870	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I39_05880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I39_05885	COG2105	PFAM AIG2 family protein
I6I39_05890	COG2911	Protein conserved in bacteria
I6I39_05900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I39_05905	COG1253	flavin adenine dinucleotide binding
I6I39_05915	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6I39_05920	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I39_05925	COG0737	Belongs to the 5'-nucleotidase family
I6I39_05935	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I39_05940	COG3061	Opacity-associated protein A
I6I39_05950	COG0359	binds to the 23S rRNA
I6I39_05955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I39_05960	COG2965	DNA replication, synthesis of RNA primer
I6I39_05965	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I39_05975	COG1073	alpha beta
I6I39_05980	COG3650	response to hydrogen peroxide
I6I39_05985	COG1960	acyl-CoA dehydrogenase activity
I6I39_05990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I39_05995	COG0557	exoribonuclease II activity
I6I39_06000	COG1959	2 iron, 2 sulfur cluster binding
I6I39_06005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I39_06010	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6I39_06015	COG0330	HflC and HflK could
I6I39_06020	COG0330	HflC and HflK could
I6I39_06025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I39_06030	COG1923	regulation of RNA biosynthetic process
I6I39_06035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I39_06040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I39_06045	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I39_06050	COG0802	atpase or kinase
I6I39_06055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I39_06055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I39_06060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I39_06080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I39_06085	COG1162	GTPase activity
I6I39_06090	COG0688	phosphatidylethanolamine metabolic process
I6I39_06095	COG1511	domain protein
I6I39_06095	COG3264	Mechanosensitive ion channel
I6I39_06100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6I39_06105	COG1053	succinate dehydrogenase
I6I39_06110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I39_06115	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I39_06120	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I39_06140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I39_06155	COG0459	protein refolding
I6I39_06160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I39_06175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I39_06185	COG4232	protein-disulfide reductase activity
I6I39_06190	COG1929	Belongs to the glycerate kinase type-1 family
I6I39_06195	COG1309	transcriptional regulator
I6I39_06205	COG1882	Formate acetyltransferase
I6I39_06210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I39_06215	COG0814	amino acid
I6I39_06220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I39_06230	COG3721	Heme iron utilization protein
I6I39_06250	COG3720	iron ion transport
I6I39_06255	COG4558	Periplasmic binding protein
I6I39_06260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I39_06265	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I39_06270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_06280	COG4774	siderophore transport
I6I39_06285	COG1511	domain protein
I6I39_06285	COG3264	Mechanosensitive ion channel
I6I39_06290	COG4115	mRNA cleavage
I6I39_06295	COG2161	toxin-antitoxin pair type II binding
I6I39_06300	COG0612	Peptidase, M16
I6I39_06305	COG4178	(ABC) transporter
I6I39_06310	COG4771	TonB-dependent receptor
I6I39_06315	COG3712	iron ion homeostasis
I6I39_06330	COG0425	Belongs to the sulfur carrier protein TusA family
I6I39_06495	COG2197	response regulator
I6I39_06500	COG1301	dicarboxylic acid transport
I6I39_06505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I39_06510	COG3162	membrane
I6I39_06515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I39_06555	COG0138	bifunctional purine biosynthesis protein purh
I6I39_06560	COG0151	Belongs to the GarS family
I6I39_06580	COG1515	deoxyribonuclease V activity
I6I39_06585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I39_06590	COG2816	NAD+ diphosphatase activity
I6I39_06595	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6I39_06610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I39_06615	COG2104	thiamine diphosphate biosynthetic process
I6I39_06620	COG2022	thiamine diphosphate biosynthetic process
I6I39_06635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I39_06640	COG0085	RNA polymerase activity
I6I39_06645	COG0222	ribosome binding
I6I39_06650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I39_06655	COG0081	regulation of translation
I6I39_06660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I39_06665	COG0250	Participates in transcription elongation, termination and antitermination
I6I39_06675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I39_06710	COG1072	(Pantothenic acid kinase))
I6I39_06715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I39_06715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I39_06760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I39_06765	COG1739	Uncharacterized protein family UPF0029
I6I39_06770	COG0006	proline dipeptidase activity
I6I39_06775	COG1024	Enoyl-CoA hydratase
I6I39_06775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I39_06780	COG0183	Belongs to the thiolase family
I6I39_06790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I39_06810	COG0805	protein transport
I6I39_06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I39_06820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I39_06825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I39_06835	COG2226	methyltransferase
I6I39_06840	COG1322	Protein conserved in bacteria
I6I39_06845	COG0586	Pfam SNARE associated Golgi protein
I6I39_06850	COG1966	Carbon starvation protein
I6I39_06870	COG0412	Dienelactone hydrolase
I6I39_06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I39_06880	COG0583	DNA-binding transcription factor activity
I6I39_06885	COG0697	spore germination
I6I39_06890	COG0679	Auxin Efflux Carrier
I6I39_06895	COG0584	glycerophosphoryl diester phosphodiesterase
I6I39_06900	COG3842	ATPase activity
I6I39_06905	COG0395	ABC-type sugar transport system, permease component
I6I39_06910	COG1175	transmembrane transport
I6I39_06915	COG1653	transport
I6I39_06950	COG0410	ABC transporter
I6I39_06960	COG4177	L-phenylalanine transmembrane transporter activity
I6I39_06970	COG0683	leucine binding
I6I39_07000	COG2177	Part of the ABC transporter FtsEX involved in
I6I39_07005	COG2884	Cell division ATP-binding protein ftsE
I6I39_07010	COG0552	protein localization to endoplasmic reticulum
I6I39_07015	COG0742	ribosomal rna small subunit methyltransferase
I6I39_07020	COG3776	membrane
I6I39_07035	COG3714	YhhN family
I6I39_07040	COG2217	Heavy metal translocating P-type atpase
I6I39_07045	COG0425	Belongs to the sulfur carrier protein TusA family
I6I39_07050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I39_07060	COG0247	lactate metabolic process
I6I39_07065	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6I39_07070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I39_07080	COG2271	Major facilitator Superfamily
I6I39_07085	COG0584	glycerophosphoryl diester phosphodiesterase
I6I39_07095	COG0561	phosphatase activity
I6I39_07100	COG2267	carboxylic ester hydrolase activity
I6I39_07105	COG1280	lysine exporter protein (LysE YggA)
I6I39_07110	COG1280	lysine exporter protein (LysE YggA)
I6I39_07115	COG0514	ATP-dependent DNA helicase (RecQ)
I6I39_07120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6I39_07125	COG2050	protein possibly involved in aromatic compounds catabolism
I6I39_07140	COG5564	TIM-barrel signal transduction protein
I6I39_07145	COG5441	Belongs to the UPF0261 family
I6I39_07155	COG0210	DNA helicase
I6I39_07160	COG1011	Hydrolase
I6I39_07165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I39_07170	COG3159	Protein conserved in bacteria
I6I39_07175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I39_07185	COG1965	Belongs to the frataxin family
I6I39_07190	COG3072	Adenylate cyclase
I6I39_07195	COG0181	hydroxymethylbilane synthase activity
I6I39_07200	COG1587	Uroporphyrinogen-III synthase
I6I39_07205	COG2959	enzyme of heme biosynthesis
I6I39_07210	COG3071	HemY protein
I6I39_07255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I39_07260	COG2244	polysaccharide biosynthetic process
I6I39_07265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I39_07270	COG0456	acetyltransferase
I6I39_07275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I39_07280	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I39_07285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I39_07290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I39_07295	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6I39_07300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I39_07305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I39_07310	COG3118	belongs to the thioredoxin family
I6I39_07320	COG0248	Ppx GppA phosphatase
I6I39_07335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I39_07345	COG3121	Chaperone
I6I39_07360	COG3121	Chaperone
I6I39_07385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I39_07390	COG0583	DNA-binding transcription factor activity
I6I39_07410	COG0129	dihydroxy-acid dehydratase activity
I6I39_07415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I39_07420	COG3978	acetolactate synthase activity
I6I39_07440	COG3085	chromosome segregation
I6I39_07445	COG0583	DNA-binding transcription factor activity
I6I39_07450	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_07455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_07460	COG1129	ABC transporter
I6I39_07465	COG1879	ABC-type sugar transport system periplasmic component
I6I39_07505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I39_07515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I39_07525	COG1309	transcriptional regulator
I6I39_07530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_07540	COG0678	peroxiredoxin activity
I6I39_07540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I39_07545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_07585	COG1629	transport
I6I39_07590	COG0165	Argininosuccinate lyase
I6I39_07595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I39_07610	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I39_07620	COG0527	aspartate kinase activity
I6I39_07620	COG0460	homoserine dehydrogenase
I6I39_07625	COG0626	cystathionine gamma-synthase activity
I6I39_07630	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6I39_07635	COG0254	rRNA binding
I6I39_07640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I39_07645	COG1609	Transcriptional regulator
I6I39_07650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I39_07655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I39_07660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I39_07665	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I39_07670	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I39_07675	COG3074	FtsZ-dependent cytokinesis
I6I39_07680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I39_07690	COG1494	fructose-1,6-bisphosphatase
I6I39_07700	COG2814	Major facilitator Superfamily
I6I39_07720	COG3152	Membrane
I6I39_07730	COG0149	triose-phosphate isomerase activity
I6I39_07740	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I39_07750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I39_07830	COG4695	Portal protein
I6I39_07845	COG0653	protein targeting
I6I39_07870	COG4974	Belongs to the 'phage' integrase family
I6I39_07875	COG3678	ATP-independent chaperone mediated protein folding
I6I39_07880	COG0745	RESPONSE REGULATOR receiver
I6I39_07885	COG2205	protein histidine kinase activity
I6I39_07890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I39_07890	COG2169	Transcriptional regulator
I6I39_07895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I39_07900	COG1045	serine acetyltransferase
I6I39_07905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I39_07910	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I39_07915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I39_07920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I39_07925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I39_07930	COG4942	peptidase
I6I39_07935	COG2861	carbohydrate metabolic process
I6I39_07950	COG1063	alcohol dehydrogenase
I6I39_07955	COG0156	8-amino-7-oxononanoate synthase activity
I6I39_07960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_07965	COG0859	PFAM glycosyl transferase family 9
I6I39_07970	COG0859	PFAM glycosyl transferase family 9
I6I39_07975	COG1519	Transferase
I6I39_07985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I39_07990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I39_07995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I39_08000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I39_08005	COG2003	Belongs to the UPF0758 family
I6I39_08010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I39_08015	COG0756	dUTP diphosphatase activity
I6I39_08020	COG1309	transcriptional regulator
I6I39_08030	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I39_08035	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I39_08040	COG1561	YicC-like family, N-terminal region
I6I39_08050	COG5001	Diguanylate cyclase
I6I39_08055	COG1024	Enoyl-CoA hydratase
I6I39_08060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I39_08070	COG2860	membrane
I6I39_08075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I39_08085	COG1758	RNA polymerase activity
I6I39_08090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I39_08095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I39_08100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I39_08110	COG0786	glutamate:sodium symporter activity
I6I39_08115	COG2233	PERMEase
I6I39_08120	COG2982	Protein involved in outer membrane biogenesis
I6I39_08140	COG3423	Transcriptional regulator
I6I39_08145	COG0456	acetyltransferase
I6I39_08150	COG1490	D-aminoacyl-tRNA deacylase activity
I6I39_08155	COG1295	ribonuclease BN
I6I39_08160	COG1011	Hydrolase
I6I39_08175	COG3852	Histidine kinase
I6I39_08185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I39_08190	COG3078	GTPase activator activity
I6I39_08195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I39_08200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I39_08200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I39_08205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I39_08210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I39_08215	COG3084	Protein conserved in bacteria
I6I39_08225	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I39_08255	COG2186	Transcriptional regulator
I6I39_08260	COG0477	Major facilitator Superfamily
I6I39_08265	COG1609	Transcriptional regulator
I6I39_08270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_08275	COG1879	ABC-type sugar transport system periplasmic component
I6I39_08280	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_08290	COG1869	D-ribose catabolic process
I6I39_08295	COG3158	transport of potassium into the cell
I6I39_08300	COG0714	Associated with various cellular activities
I6I39_08305	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6I39_08315	COG2502	aspartate--ammonia ligase
I6I39_08320	COG1522	sequence-specific DNA binding
I6I39_08325	COG0716	FMN binding
I6I39_08330	COG0445	tRNA wobble uridine modification
I6I39_08335	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I39_08340	COG3312	ion transport
I6I39_08345	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I39_08355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I39_08360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I39_08365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I39_08370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I39_08375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I39_08380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I39_08385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I39_08395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I39_08400	COG0573	inorganic phosphate transmembrane transporter activity
I6I39_08405	COG0581	inorganic phosphate transmembrane transporter activity
I6I39_08415	COG0704	Plays a role in the regulation of phosphate uptake
I6I39_08425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_08430	COG0765	amino acid transport
I6I39_08435	COG0765	amino acid transport
I6I39_08440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_08445	COG2252	PERMEase
I6I39_08455	COG4566	intracellular signal transduction
I6I39_08465	COG0431	NADPH-dependent FMN reductase
I6I39_08470	COG0840	transmembrane signaling receptor activity
I6I39_08475	COG2011	ABC-type metal ion transport system permease component
I6I39_08490	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I39_08495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I39_08500	COG0706	membrane insertase activity
I6I39_08510	COG0594	ribonuclease P activity
I6I39_08515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I39_08520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I39_08525	COG0592	DNA-directed DNA polymerase activity
I6I39_08530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I39_08535	COG0187	DNA topoisomerase II activity
I6I39_08540	COG0561	phosphatase activity
I6I39_08545	COG2423	ornithine cyclodeaminase activity
I6I39_08555	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_08560	COG5645	(Lipo)protein
I6I39_08575	COG0569	domain protein
I6I39_08575	COG2985	domain, Protein
I6I39_08580	COG3977	Valine--pyruvate aminotransferase
I6I39_08585	COG0366	Alpha amylase catalytic
I6I39_08590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I39_08620	COG0456	acetyltransferase
I6I39_08625	COG2818	Glycosylase
I6I39_08630	COG0752	glycyl-tRNA synthetase alpha subunit
I6I39_08635	COG0751	glycine-tRNA ligase activity
I6I39_08645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_08645	COG2213	PTS system mannitol-specific
I6I39_08650	COG0246	Mannitol dehydrogenase
I6I39_08655	COG3722	fumarate hydratase activity
I6I39_08665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_08685	COG2258	MOSC domain
I6I39_08690	COG0840	transmembrane signaling receptor activity
I6I39_08695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I39_08700	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I39_08710	COG0437	4 iron, 4 sulfur cluster binding
I6I39_08715	COG2864	formate dehydrogenase
I6I39_08720	COG3058	Necessary for formate dehydrogenase activity
I6I39_08725	COG1921	L-seryl-tRNASec selenium transferase activity
I6I39_08730	COG3276	selenocysteine insertion sequence binding
I6I39_08740	COG3274	enterobacterial common antigen metabolic process
I6I39_08755	COG3121	Chaperone
I6I39_08760	COG1070	Carbohydrate kinase
I6I39_08765	COG2115	Belongs to the xylose isomerase family
I6I39_08770	COG4213	ABC transporter substrate-binding protein
I6I39_08780	COG4214	carbohydrate transport
I6I39_08795	COG0582	viral genome integration into host DNA
I6I39_08835	COG2986	histidine ammonia-lyase
I6I39_08840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I39_08865	COG1482	cell wall glycoprotein biosynthetic process
I6I39_08870	COG2723	6-phospho-beta-galactosidase activity
I6I39_08885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_08890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_08895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I39_08900	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I39_08905	COG1940	carbohydrate kinase activity
I6I39_08910	COG1609	Transcriptional regulator
I6I39_08935	COG3328	transposase activity
I6I39_08945	COG3210	domain, Protein
I6I39_08950	COG2831	hemolysin activation secretion protein
I6I39_08965	COG2271	Major facilitator Superfamily
I6I39_08970	COG3851	Histidine kinase
I6I39_08975	COG2197	response regulator
I6I39_08980	COG2194	sulfuric ester hydrolase activity
I6I39_08985	COG1764	response to oxidative stress
I6I39_08995	COG0747	negative chemotaxis
I6I39_09000	COG0601	transmembrane transport
I6I39_09005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_09010	COG0444	Belongs to the ABC transporter superfamily
I6I39_09015	COG4608	Belongs to the ABC transporter superfamily
I6I39_09020	COG2194	sulfuric ester hydrolase activity
I6I39_09040	COG1192	Involved in chromosome partitioning
I6I39_09045	COG1215	transferase activity, transferring glycosyl groups
I6I39_09050	COG1215	transferase activity, transferring glycosyl groups
I6I39_09055	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I39_09060	COG3118	belongs to the thioredoxin family
I6I39_09060	COG0457	Tetratricopeptide repeat
I6I39_09065	COG2200	EAL domain
I6I39_09065	COG2199	diguanylate cyclase activity
I6I39_09070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I39_09085	COG1301	dicarboxylic acid transport
I6I39_09090	COG0612	Peptidase, M16
I6I39_09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_09100	COG1942	4-Oxalocrotonate Tautomerase
I6I39_09105	COG2200	EAL domain
I6I39_09110	COG2982	Protein involved in outer membrane biogenesis
I6I39_09115	COG2134	cdp-diacylglycerol pyrophosphatase
I6I39_09120	COG1295	ribonuclease BN
I6I39_09130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I39_09135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I39_09145	COG0742	ribosomal rna small subunit methyltransferase
I6I39_09160	COG0589	response to stress
I6I39_09170	COG0306	phosphate transporter
I6I39_09175	COG2081	HI0933 family
I6I39_09180	COG1301	dicarboxylic acid transport
I6I39_09195	COG3799	methylaspartate ammonia-lyase activity
I6I39_09200	COG4865	methylaspartate mutase activity
I6I39_09210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I39_09220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I39_09220	COG1648	precorrin-2 dehydrogenase activity
I6I39_09225	COG0583	DNA-binding transcription factor activity
I6I39_09230	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_09230	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_09240	COG0561	phosphatase activity
I6I39_09250	COG0583	DNA-binding transcription factor activity
I6I39_09255	COG2814	Major facilitator Superfamily
I6I39_09265	COG3718	enzyme involved in inositol metabolism
I6I39_09275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_09285	COG0673	inositol 2-dehydrogenase activity
I6I39_09290	COG1082	Xylose isomerase domain protein TIM barrel
I6I39_09295	COG1247	-acetyltransferase
I6I39_09300	COG1741	Belongs to the pirin family
I6I39_09305	COG1609	Transcriptional regulator
I6I39_09310	COG2610	gluconate transmembrane transporter activity
I6I39_09315	COG3265	gluconokinase activity
I6I39_09320	COG2095	MarC family integral membrane protein
I6I39_09325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I39_09345	COG3275	phosphorelay sensor kinase activity
I6I39_09350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I39_09355	COG1523	belongs to the glycosyl hydrolase 13 family
I6I39_09365	COG0297	glycogen (starch) synthase activity
I6I39_09370	COG0058	SHG alpha-glucan phosphorylase activity
I6I39_09375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I39_09385	COG1349	DNA-binding transcription factor activity
I6I39_09390	COG0705	Rhomboid family
I6I39_09405	COG2909	trisaccharide binding
I6I39_09410	COG0058	SHG alpha-glucan phosphorylase activity
I6I39_09415	COG1640	4-alpha-glucanotransferase
I6I39_09425	COG0316	Belongs to the HesB IscA family
I6I39_09425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I39_09435	COG0596	Alpha beta hydrolase
I6I39_09450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I39_09455	COG1918	ferrous iron import across plasma membrane
I6I39_09460	COG2183	response to ionizing radiation
I6I39_09485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I39_09500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I39_09510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I39_09515	COG1011	Hydrolase
I6I39_09525	COG0494	nUDIX hydrolase
I6I39_09530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I39_09555	COG4796	Type ii and iii secretion system protein
I6I39_09560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I39_09580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I39_09590	COG0180	Tryptophanyl-tRNA synthetase
I6I39_09595	COG1648	precorrin-2 dehydrogenase activity
I6I39_09595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I39_09610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I39_09615	COG0402	S-adenosylhomocysteine deaminase activity
I6I39_09620	COG0738	Major facilitator superfamily
I6I39_09630	COG1486	melibiose metabolic process
I6I39_09635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I39_09640	COG0433	COG0433 Predicted ATPase
I6I39_09655	COG1289	transmembrane transporter activity
I6I39_09665	COG1765	OsmC-like protein
I6I39_09670	COG3954	Phosphoribulokinase
I6I39_09675	COG3089	Belongs to the UPF0270 family
I6I39_09680	COG0429	hydrolase of the alpha beta-hydrolase fold
I6I39_09695	COG4521	taurine ABC transporter
I6I39_09705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I39_09710	COG2175	clavaminate synthase activity
I6I39_09720	COG1216	Glycosyl transferase, family 2
I6I39_09725	COG0488	(ABC) transporter
I6I39_09730	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I39_09740	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I39_09745	COG1047	Peptidyl-prolyl cis-trans
I6I39_09750	COG2900	Belongs to the SlyX family
I6I39_09755	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I39_09760	COG2964	Protein conserved in bacteria
I6I39_09765	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I39_09770	COG2923	Belongs to the DsrF TusC family
I6I39_09775	COG2168	tRNA wobble position uridine thiolation
I6I39_09780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I39_09785	COG0049	tRNA binding
I6I39_09795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I39_09810	COG0051	transcription antitermination factor activity, RNA binding
I6I39_09815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I39_09820	COG0088	Forms part of the polypeptide exit tunnel
I6I39_09825	COG0089	rRNA binding
I6I39_09830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I39_09835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I39_09840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I39_09845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I39_09850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I39_09855	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I39_09860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I39_09865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I39_09870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I39_09875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I39_09880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I39_09890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I39_09895	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I39_09900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I39_09905	COG1841	ribosomal large subunit assembly
I6I39_09910	COG0200	Binds to the 23S rRNA
I6I39_09915	COG0201	protein transport
I6I39_09920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I39_09925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I39_09930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I39_09935	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I39_09940	COG0202	RNA polymerase activity
I6I39_09945	COG0203	ribosomal protein L17
I6I39_09955	COG0789	Transcriptional regulator
I6I39_09960	COG3036	rescue of stalled ribosome
I6I39_09975	COG1970	mechanosensitive ion channel activity
I6I39_09985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I39_09985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I39_09990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I39_09995	COG0242	peptide deformylase activity
I6I39_10000	COG0758	DNA mediated transformation
I6I39_10010	COG0551	DNA topoisomerase type I activity
I6I39_10015	COG0009	L-threonylcarbamoyladenylate synthase
I6I39_10020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I39_10025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I39_10065	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6I39_10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I39_10075	COG2224	Isocitrate lyase
I6I39_10080	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I39_10085	COG1414	Transcriptional regulator
I6I39_10110	COG0527	aspartate kinase activity
I6I39_10115	COG0166	Belongs to the GPI family
I6I39_10125	COG3833	ABC-type maltose transport systems, permease component
I6I39_10130	COG1175	transmembrane transport
I6I39_10135	COG2182	Extracellular solute-binding protein
I6I39_10150	COG4580	involved in the transport of maltose and maltodextrins
I6I39_10165	COG3161	chorismate lyase activity
I6I39_10170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I39_10175	COG2937	Belongs to the GPAT DAPAT family
I6I39_10180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I39_10185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I39_10190	COG3237	CsbD-like
I6I39_10195	COG0735	belongs to the Fur family
I6I39_10200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I39_10200	COG2755	lipolytic protein G-D-S-L family
I6I39_10205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I39_10235	COG1448	Aminotransferase
I6I39_10240	COG2315	Protein conserved in bacteria
I6I39_10245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I39_10255	COG3550	peptidyl-serine autophosphorylation
I6I39_10270	COG2252	PERMEase
I6I39_10275	COG0025	NhaP-type Na H and K H
I6I39_10280	COG0583	DNA-binding transcription factor activity
I6I39_10285	COG1380	Effector of murein hydrolase LrgA
I6I39_10295	COG1126	abc transporter atp-binding protein
I6I39_10300	COG0765	amino acid transport
I6I39_10305	COG4597	amino acid ABC transporter
I6I39_10310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_10325	COG1560	Kdo2-lipid A biosynthetic process
I6I39_10330	COG0471	metal ion transport
I6I39_10335	COG1278	Cold shock
I6I39_10340	COG1278	Cold shock
I6I39_10345	COG3133	Outer membrane lipoprotein
I6I39_10355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I39_10360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I39_10365	COG2264	protein methyltransferase activity
I6I39_10370	COG4145	pantothenate transmembrane transporter activity
I6I39_10375	COG3924	membrane
I6I39_10380	COG0439	Biotin carboxylase
I6I39_10385	COG0511	ligase activity, forming carbon-carbon bonds
I6I39_10390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I39_10395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I39_10405	COG0604	alcohol dehydrogenase
I6I39_10410	COG2199	diguanylate cyclase activity
I6I39_10410	COG2200	EAL domain
I6I39_10415	COG1077	Cell shape determining protein MreB Mrl
I6I39_10420	COG1792	Involved in formation and maintenance of cell shape
I6I39_10425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I39_10430	COG0424	maF-like protein
I6I39_10440	COG3164	Protein of unknown function
I6I39_10445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I39_10450	COG0312	modulator of DNA gyrase
I6I39_10510	COG0583	DNA-binding transcription factor activity
I6I39_10520	COG1566	PFAM secretion protein HlyD family protein
I6I39_10525	COG1289	transmembrane transporter activity
I6I39_10540	COG2732	(Barnase) inhibitor
I6I39_10545	COG3028	Belongs to the UPF0307 family
I6I39_10550	COG0312	modulator of DNA gyrase
I6I39_10555	COG3783	Cytochrome b(562)
I6I39_10560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I39_10590	COG3964	amidohydrolase
I6I39_10605	COG2706	6-phosphogluconolactonase activity
I6I39_10610	COG3711	transcriptional antiterminator
I6I39_10610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_10615	COG3093	addiction module antidote protein HigA
I6I39_10625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I39_10635	COG1263	PTS System
I6I39_10635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_10640	COG0366	Alpha amylase catalytic
I6I39_10660	COG2308	Evidence 4 Homologs of previously reported genes of
I6I39_10670	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6I39_10675	COG0540	Belongs to the ATCase OTCase family
I6I39_10680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_10685	COG1660	Displays ATPase and GTPase activities
I6I39_10700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I39_10705	COG1137	ATPase activity
I6I39_10710	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I39_10715	COG3117	lipopolysaccharide transmembrane transporter activity
I6I39_10720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I39_10725	COG0517	IMP dehydrogenase activity
I6I39_10725	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I39_10730	COG0530	calcium, potassium:sodium antiporter activity
I6I39_10735	COG1127	ABC transporter
I6I39_10740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I39_10745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I39_10750	COG2854	intermembrane phospholipid transfer
I6I39_10755	COG3113	response to antibiotic
I6I39_10760	COG5007	Belongs to the BolA IbaG family
I6I39_10765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I39_10770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I39_10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I39_10780	COG3105	Protein conserved in bacteria
I6I39_10785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I39_10790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I39_10795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I39_10800	COG0625	glutathione transferase activity
I6I39_10805	COG2969	positive regulation of protein catabolic process
I6I39_10815	COG0493	'glutamate synthase
I6I39_10820	COG0067	glutamate synthase
I6I39_10820	COG0070	glutamate synthase
I6I39_10820	COG0069	glutamate synthase activity
I6I39_10825	COG1242	4 iron, 4 sulfur cluster binding
I6I39_10830	COG0784	Response regulator, receiver
I6I39_10830	COG2198	Histidine kinase
I6I39_10830	COG5002	protein histidine kinase activity
I6I39_10835	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I39_10840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I39_10850	COG2823	Periplasmic or secreted lipoprotein
I6I39_10855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I39_10860	COG0792	nuclease activity
I6I39_10870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I39_10915	COG3121	Chaperone
I6I39_10935	COG0667	Aldo Keto reductase
I6I39_10945	COG1741	Belongs to the pirin family
I6I39_10950	COG0583	DNA-binding transcription factor activity
I6I39_10955	COG0435	Glutathione S-transferase
I6I39_10960	COG2259	Doxx family
I6I39_10970	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6I39_10975	COG4575	ribosome binding
I6I39_10990	COG0586	Pfam SNARE associated Golgi protein
I6I39_11005	COG2271	Major facilitator Superfamily
I6I39_11010	COG1904	glucuronate isomerase
I6I39_11015	COG0246	Mannitol dehydrogenase
I6I39_11020	COG2721	sulfolactate sulfo-lyase activity
I6I39_11030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I39_11035	COG0861	Integral membrane protein TerC family
I6I39_11040	COG0673	inositol 2-dehydrogenase activity
I6I39_11045	COG1451	nucleotide metabolic process
I6I39_11065	COG2813	Specifically methylates the guanine in position
I6I39_11070	COG1902	pentaerythritol trinitrate reductase activity
I6I39_11070	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I39_11080	COG3247	response to pH
I6I39_11085	COG0076	glutamate decarboxylase activity
I6I39_11090	COG0531	amino acid
I6I39_11100	COG1263	PTS System
I6I39_11100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_11105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I39_11115	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I39_11125	COG3876	Protein conserved in bacteria
I6I39_11130	COG4974	Belongs to the 'phage' integrase family
I6I39_11185	COG4695	Portal protein
I6I39_11325	COG0358	DNA primase activity
I6I39_11330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I39_11335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I39_11340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I39_11345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I39_11350	COG1968	undecaprenyl-diphosphatase activity
I6I39_11355	COG0617	tRNA 3'-terminal CCA addition
I6I39_11360	COG4991	sh3 domain protein
I6I39_11365	COG3025	triphosphatase activity
I6I39_11370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I39_11375	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I39_11375	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I39_11380	COG0531	amino acid
I6I39_11390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I39_11395	COG3384	dioxygenase
I6I39_11400	COG0754	glutathionylspermidine amidase activity
I6I39_11405	COG5463	Belongs to the UPF0441 family
I6I39_11410	COG1538	Outer membrane efflux protein
I6I39_11415	COG0494	nUDIX hydrolase
I6I39_11420	COG3151	Protein conserved in bacteria
I6I39_11430	COG3150	esterase
I6I39_11445	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I39_11450	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I39_11455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I39_11465	COG2132	Multicopper oxidase
I6I39_11475	COG0656	L-ascorbic acid biosynthetic process
I6I39_11480	COG1979	alcohol dehydrogenase
I6I39_11485	COG2207	Transcriptional regulator
I6I39_11490	COG0586	Pfam SNARE associated Golgi protein
I6I39_11495	COG0626	cystathionine gamma-synthase activity
I6I39_11505	COG0848	biopolymer transport protein
I6I39_11555	COG4964	Belongs to the GSP D family
I6I39_11640	COG1136	(ABC) transporter
I6I39_11640	COG0577	efflux transmembrane transporter activity
I6I39_11675	COG1815	bacterial-type flagellum-dependent cell motility
I6I39_11680	COG1558	bacterial-type flagellum-dependent cell motility
I6I39_11685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I39_11700	COG4786	Flagellar basal body rod
I6I39_11710	COG1706	bacterial-type flagellum-dependent cell motility
I6I39_11740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I39_11745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I39_11750	COG1516	flagellar protein fliS
I6I39_11770	COG1191	sigma factor activity
I6I39_11775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I39_11785	COG3133	Outer membrane lipoprotein
I6I39_11790	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6I39_11795	COG0437	4 iron, 4 sulfur cluster binding
I6I39_11800	COG5557	Pfam Polysulphide reductase, NrfD
I6I39_11805	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6I39_11810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I39_11815	COG1773	rubredoxin
I6I39_11825	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I39_11830	COG0298	carbon dioxide binding
I6I39_11835	COG0409	Hydrogenase expression formation protein
I6I39_11840	COG0309	Hydrogenase expression formation protein (HypE)
I6I39_11845	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6I39_11855	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I39_11865	COG5001	Diguanylate cyclase
I6I39_11880	COG0477	Major facilitator Superfamily
I6I39_11895	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I39_11905	COG1609	Transcriptional regulator
I6I39_11910	COG0477	Major facilitator Superfamily
I6I39_11915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_11920	COG0697	spore germination
I6I39_11935	COG4607	ABC-type enterochelin transport system periplasmic component
I6I39_11945	COG4605	iron ion homeostasis
I6I39_11950	COG4604	ABC transporter, ATP-binding protein
I6I39_11955	COG0024	Methionine aminopeptidase
I6I39_11980	COG1289	transmembrane transporter activity
I6I39_11995	COG1982	Orn Lys Arg decarboxylase major
I6I39_12000	COG0531	amino acid
I6I39_12045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I39_12055	COG1982	Orn Lys Arg decarboxylase major
I6I39_12065	COG0741	lytic transglycosylase activity
I6I39_12070	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I39_12075	COG1194	a g-specific adenine glycosylase
I6I39_12080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I39_12085	COG3171	Protein conserved in bacteria
I6I39_12100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I39_12105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I39_12110	COG1872	DUF167
I6I39_12115	COG0762	integral membrane protein
I6I39_12120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I39_12125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I39_12130	COG2805	Type II/IV secretion system protein
I6I39_12140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I39_12145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I39_12150	COG1678	Uncharacterized ACR, COG1678
I6I39_12155	COG0189	ligase activity
I6I39_12160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I39_12165	COG2356	endonuclease I
I6I39_12170	COG3091	SprT-like family
I6I39_12175	COG0640	Transcriptional regulator
I6I39_12190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I39_12195	COG1166	arginine decarboxylase activity
I6I39_12205	COG0501	Belongs to the peptidase M48B family
I6I39_12210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I39_12215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I39_12220	COG0126	phosphoglycerate kinase activity
I6I39_12225	COG0191	fructose-bisphosphate aldolase activity
I6I39_12245	COG1279	arginine transmembrane transporter activity
I6I39_12255	COG0583	DNA-binding transcription factor activity
I6I39_12260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I39_12265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I39_12300	COG0602	queuosine metabolic process
I6I39_12320	COG0720	synthase
I6I39_12325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I39_12330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I39_12335	COG0175	sulfate reduction
I6I39_12350	COG2234	aminopeptidase activity
I6I39_12355	COG1648	precorrin-2 dehydrogenase activity
I6I39_12355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I39_12360	COG0175	sulfate reduction
I6I39_12365	COG2895	sulfate adenylyltransferase (ATP) activity
I6I39_12370	COG0529	Catalyzes the synthesis of activated sulfate
I6I39_12380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6I39_12390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I39_12395	COG0585	pseudouridine synthase activity
I6I39_12400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I39_12405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I39_12410	COG1388	LysM domain
I6I39_12410	COG4942	peptidase
I6I39_12415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I39_12420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I39_12445	COG3188	usher protein
I6I39_12450	COG3121	Chaperone
I6I39_12460	COG3539	Fimbrial protein
I6I39_12465	COG3539	Fimbrial protein
I6I39_12495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_12505	COG1538	Outer membrane efflux protein
I6I39_12525	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_12535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I39_12540	COG1858	cytochrome C peroxidase
I6I39_12550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I39_12555	COG0640	Transcriptional regulator
I6I39_12610	COG0410	ABC transporter
I6I39_12615	COG1137	ATPase activity
I6I39_12620	COG4177	L-phenylalanine transmembrane transporter activity
I6I39_12635	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_12635	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I39_12640	COG0243	molybdopterin cofactor binding
I6I39_12645	COG0437	4 iron, 4 sulfur cluster binding
I6I39_12650	COG3302	dmso reductase anchor subunit
I6I39_12655	COG3381	protein complex oligomerization
I6I39_12675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I39_12680	COG2137	regulation of response to DNA damage stimulus
I6I39_12685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I39_12690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I39_12715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_12720	COG1238	metal cluster binding
I6I39_12725	COG2918	glutathione biosynthetic process
I6I39_12730	COG1854	S-ribosylhomocysteine lyase activity
I6I39_12735	COG4536	flavin adenine dinucleotide binding
I6I39_12740	COG4137	Cytochrome C assembly protein
I6I39_12745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I39_12750	COG0228	four-way junction DNA binding
I6I39_12755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I39_12760	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I39_12765	COG0335	large ribosomal subunit rRNA binding
I6I39_12770	COG3137	Salt-induced outer membrane protein
I6I39_12775	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I39_12780	COG3279	Response regulator of the LytR AlgR family
I6I39_12785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I39_12790	COG1605	Chorismate mutase
I6I39_12790	COG0287	Prephenate dehydrogenase
I6I39_12795	COG0077	Prephenate dehydratase
I6I39_12795	COG1605	Chorismate mutase
I6I39_12805	COG0542	response to heat
I6I39_12815	COG0564	pseudouridine synthase activity
I6I39_12820	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I39_12825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I39_12850	COG5544	Lipoprotein
I6I39_12855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I39_12860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I39_12860	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I39_12860	COG1042	CoA-binding domain protein
I6I39_12865	COG3148	PFAM DTW domain containing protein
I6I39_12870	COG3118	belongs to the thioredoxin family
I6I39_12875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I39_12885	COG2814	Major facilitator Superfamily
I6I39_12890	COG1566	PFAM secretion protein HlyD family protein
I6I39_12895	COG1538	Outer membrane efflux protein
I6I39_12900	COG1846	Transcriptional regulator
I6I39_12910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I39_12915	COG2814	Major facilitator Superfamily
I6I39_12955	COG0765	amino acid transport
I6I39_12960	COG0765	amino acid transport
I6I39_12970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I39_12985	COG0436	Aminotransferase
I6I39_12990	COG0235	Class ii aldolase
I6I39_12995	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I39_13000	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I39_13005	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I39_13010	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6I39_13015	COG2831	hemolysin activation secretion protein
I6I39_13030	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
I6I39_13035	COG1960	acyl-CoA dehydrogenase activity
I6I39_13045	COG0121	glutamine amidotransferase
I6I39_13050	COG3034	peptidoglycan biosynthetic process
I6I39_13055	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_13060	COG1805	sodium ion transport
I6I39_13065	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_13070	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_13075	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I39_13080	COG2871	sodium ion transport
I6I39_13085	COG1477	protein flavinylation
I6I39_13090	COG2991	Protein conserved in bacteria
I6I39_13100	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I39_13105	COG2964	Protein conserved in bacteria
I6I39_13120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I39_13125	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I39_13130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I39_13135	COG1073	alpha beta
I6I39_13145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I39_13150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I39_13155	COG2188	Transcriptional regulator
I6I39_13175	COG3459	Glycosyltransferase 36 associated
I6I39_13190	COG2226	methyltransferase
I6I39_13215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I39_13220	COG3123	guanosine phosphorylase activity
I6I39_13225	COG2974	May be involved in recombination
I6I39_13230	COG1940	carbohydrate kinase activity
I6I39_13235	COG0419	ATPase involved in DNA repair
I6I39_13240	COG0420	3'-5' exonuclease activity
I6I39_13245	COG0745	RESPONSE REGULATOR receiver
I6I39_13250	COG5002	protein histidine kinase activity
I6I39_13270	COG0366	Alpha amylase catalytic
I6I39_13290	COG0450	alkyl hydroperoxide reductase
I6I39_13295	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6I39_13300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I39_13315	COG0343	queuine tRNA-ribosyltransferase activity
I6I39_13320	COG1862	Preprotein translocase
I6I39_13325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I39_13330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I39_13345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I39_13350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I39_13350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I39_13355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I39_13360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I39_13365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I39_13370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I39_13380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I39_13385	COG0142	geranyltranstransferase activity
I6I39_13395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I39_13395	COG0301	tRNA thio-modification
I6I39_13405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I39_13410	COG1666	GTP binding
I6I39_13415	COG2814	Major facilitator Superfamily
I6I39_13420	COG0109	protoheme IX farnesyltransferase activity
I6I39_13425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I39_13430	COG1845	cytochrome c oxidase, subunit III
I6I39_13435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I39_13440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I39_13450	COG2223	nitrite transmembrane transporter activity
I6I39_13455	COG3056	Lipoprotein
I6I39_13460	COG0271	Belongs to the BolA IbaG family
I6I39_13465	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I39_13470	COG0740	serine-type endopeptidase activity
I6I39_13475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I39_13480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I39_13485	COG0776	regulation of translation
I6I39_13490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I39_13495	COG1555	photosystem II stabilization
I6I39_13500	COG0824	Thioesterase
I6I39_13505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I39_13510	COG4533	DNA binding
I6I39_13515	COG0561	phosphatase activity
I6I39_13525	COG1522	sequence-specific DNA binding
I6I39_13530	COG1132	(ABC) transporter
I6I39_13535	COG1132	(ABC) transporter
I6I39_13540	COG0347	Belongs to the P(II) protein family
I6I39_13545	COG0004	ammonium transporteR
I6I39_13550	COG1946	Acyl-CoA thioesterase
I6I39_13555	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6I39_13560	COG3695	enzyme binding
I6I39_13590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_13595	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I39_13600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I39_13605	COG0254	rRNA binding
I6I39_13620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I39_13625	COG3457	Alanine racemase
I6I39_13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I39_13645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_13650	COG1309	transcriptional regulator
I6I39_13655	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I39_13660	COG1196	nuclear chromosome segregation
I6I39_13660	COG3264	Mechanosensitive ion channel
I6I39_13675	COG2832	Protein of unknown function (DUF454)
I6I39_13680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I39_13690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I39_13695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I39_13700	COG0326	Molecular chaperone. Has ATPase activity
I6I39_13705	COG0563	adenylate kinase activity
I6I39_13710	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I39_13715	COG2244	polysaccharide biosynthetic process
I6I39_13720	COG1442	glycosyl transferase family 8
I6I39_13720	COG1216	Glycosyl transferase, family 2
I6I39_13725	COG1215	transferase activity, transferring glycosyl groups
I6I39_13730	COG0438	transferase activity, transferring glycosyl groups
I6I39_13735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I39_13740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I39_13760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_13765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I39_13765	COG4651	solute:proton antiporter activity
I6I39_13770	COG2223	nitrite transmembrane transporter activity
I6I39_13775	COG0737	Belongs to the 5'-nucleotidase family
I6I39_13780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I39_13785	COG3735	TraB family
I6I39_13790	COG2217	Heavy metal translocating P-type atpase
I6I39_13795	COG0789	Transcriptional regulator
I6I39_13800	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I39_13805	COG0330	HflC and HflK could
I6I39_13810	COG3118	belongs to the thioredoxin family
I6I39_13815	COG0300	oxidoreductase activity
I6I39_13820	COG2755	lipolytic protein G-D-S-L family
I6I39_13825	COG4181	ATPase activity
I6I39_13830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I39_13835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I39_13840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I39_13845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I39_13850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I39_13855	COG0215	cysteine-tRNA ligase activity
I6I39_13860	COG2501	S4 domain
I6I39_13865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I39_13950	COG2850	peptidyl-arginine hydroxylation
I6I39_13955	COG2986	histidine ammonia-lyase
I6I39_13970	COG5265	(ABC) transporter
I6I39_13985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I39_13995	COG2197	response regulator
I6I39_14000	COG1278	Cold shock
I6I39_14015	COG3706	GGDEF domain
I6I39_14020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I39_14025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I39_14030	COG0321	lipoyl(octanoyl) transferase activity
I6I39_14035	COG2921	Belongs to the UPF0250 family
I6I39_14040	COG1686	Belongs to the peptidase S11 family
I6I39_14045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I39_14050	COG0772	Belongs to the SEDS family
I6I39_14055	COG0768	penicillin binding
I6I39_14065	COG0799	negative regulation of ribosome biogenesis
I6I39_14070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I39_14075	COG1466	dna polymerase III delta subunit
I6I39_14080	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6I39_14085	COG0495	leucyl-tRNA aminoacylation
I6I39_14090	COG2888	peptidyl-tyrosine sulfation
I6I39_14095	COG1126	abc transporter atp-binding protein
I6I39_14100	COG0765	amino acid transport
I6I39_14105	COG0765	amino acid transport
I6I39_14120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I39_14125	COG4535	Mg2 and Co2 transporter CorC
I6I39_14130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I39_14135	COG1702	phosphate starvation-inducible protein PhoH
I6I39_14140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I39_14145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I39_14180	COG0367	asparagine synthase
I6I39_14185	COG0647	UMP catabolic process
I6I39_14190	COG1846	Transcriptional regulator
I6I39_14190	COG1940	carbohydrate kinase activity
I6I39_14195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I39_14200	COG0363	glucosamine-6-phosphate deaminase activity
I6I39_14205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_14205	COG1263	PTS System
I6I39_14205	COG2190	(PTS) system
I6I39_14210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I39_14230	COG0735	belongs to the Fur family
I6I39_14240	COG0840	transmembrane signaling receptor activity
I6I39_14250	COG0596	Alpha beta hydrolase
I6I39_14255	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6I39_14260	COG0033	Phosphoglucomutase
I6I39_14275	COG0745	RESPONSE REGULATOR receiver
I6I39_14280	COG2205	protein histidine kinase activity
I6I39_14285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I39_14290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I39_14295	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I39_14315	COG2994	toxin metabolic process
I6I39_14325	COG3272	Protein of unknown function (DUF1722)
I6I39_14335	COG5212	phosphodiesterase
I6I39_14340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I39_14350	COG1984	allophanate hydrolase subunit 2
I6I39_14355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I39_14370	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I39_14385	COG2009	succinate dehydrogenase
I6I39_14390	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I39_14395	COG1053	succinate dehydrogenase
I6I39_14405	COG0567	Dehydrogenase, E1 component
I6I39_14410	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I39_14415	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I39_14420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I39_14425	COG0737	Belongs to the 5'-nucleotidase family
I6I39_14430	COG1271	oxidase subunit
I6I39_14435	COG1294	oxidase, subunit
I6I39_14440	COG4890	Cyd operon protein YbgT
I6I39_14445	COG3790	cyd operon protein YbgE
I6I39_14450	COG0824	Thioesterase
I6I39_14455	COG0811	peptide transport
I6I39_14460	COG0848	biopolymer transport protein
I6I39_14465	COG3064	Membrane
I6I39_14465	COG3064	Membrane
I6I39_14470	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_14475	COG2885	chlorophyll binding
I6I39_14480	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I39_14515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I39_14525	COG1230	cation diffusion facilitator family transporter
I6I39_14530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I39_14535	COG0588	phosphoglycerate mutase activity
I6I39_14560	COG2017	converts alpha-aldose to the beta-anomer
I6I39_14565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I39_14570	COG1085	galactose-1-phosphate uridylyltransferase
I6I39_14575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I39_14585	COG1119	ATPase activity
I6I39_14590	COG3585	molybdate ion transport
I6I39_14590	COG2005	Transcriptional regulator
I6I39_14600	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I39_14605	COG4149	molybdate abc transporter
I6I39_14615	COG0561	phosphatase activity
I6I39_14620	COG2706	6-phosphogluconolactonase activity
I6I39_14630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I39_14635	COG0156	8-amino-7-oxononanoate synthase activity
I6I39_14640	COG2226	methyltransferase
I6I39_14655	COG0556	nucleotide-excision repair
I6I39_14660	COG4628	conserved protein (DUF2132)
I6I39_14665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I39_14670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I39_14675	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I39_14680	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I39_14685	COG0314	molybdopterin synthase activity
I6I39_14690	COG0670	Belongs to the BI1 family
I6I39_14695	COG0842	Transport permease protein
I6I39_14700	COG0842	Transport permease protein
I6I39_14705	COG1131	(ABC) transporter
I6I39_14710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I39_14715	COG1309	transcriptional regulator
I6I39_14720	COG0513	Belongs to the DEAD box helicase family
I6I39_14725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I39_14735	COG2239	Acts as a magnesium transporter
I6I39_14745	COG1686	Belongs to the peptidase S11 family
I6I39_14750	COG0277	FAD linked oxidase domain protein
I6I39_14770	COG2261	transglycosylase associated protein
I6I39_14780	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I39_14795	COG4807	Protein conserved in bacteria
I6I39_14815	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I39_14825	COG2897	thiosulfate sulfurtransferase activity
I6I39_14840	COG1732	Glycine betaine
I6I39_14845	COG1174	glycine betaine transport
I6I39_14850	COG1125	glycine betaine transport
I6I39_14855	COG1174	glycine betaine transport
I6I39_14865	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_14880	COG0697	spore germination
I6I39_14900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I39_14905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I39_14925	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I39_14935	COG1126	abc transporter atp-binding protein
I6I39_14940	COG0765	amino acid transport
I6I39_14945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_14950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I39_14955	COG0783	Belongs to the Dps family
I6I39_14960	COG4106	trans-aconitate 2-methyltransferase activity
I6I39_14975	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I39_14990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I39_15010	COG0488	(ABC) transporter
I6I39_15020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I39_15025	COG0303	'Molybdopterin
I6I39_15040	COG1136	(ABC) transporter
I6I39_15040	COG0577	efflux transmembrane transporter activity
I6I39_15070	COG0583	DNA-binding transcription factor activity
I6I39_15075	COG0477	Major facilitator Superfamily
I6I39_15080	COG0302	gtp cyclohydrolase
I6I39_15085	COG2311	Membrane
I6I39_15110	COG3604	Transcriptional regulator
I6I39_15115	COG3383	formate dehydrogenase (NAD+) activity
I6I39_15120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I39_15125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I39_15135	COG3260	NADH ubiquinone oxidoreductase 20
I6I39_15140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_15145	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6I39_15145	COG3261	NADH dehydrogenase
I6I39_15150	COG0651	ATP synthesis coupled electron transport
I6I39_15155	COG4237	Hydrogenase 4 membrane
I6I39_15160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I39_15165	COG0650	Formate hydrogenlyase subunit 4
I6I39_15170	COG0651	ATP synthesis coupled electron transport
I6I39_15175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I39_15180	COG0375	protein maturation
I6I39_15185	COG0298	carbon dioxide binding
I6I39_15190	COG2949	membrane
I6I39_15195	COG0281	malic enzyme
I6I39_15210	COG1346	cytolysis
I6I39_15215	COG1380	Effector of murein hydrolase LrgA
I6I39_15220	COG2814	Major facilitator Superfamily
I6I39_15240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I39_15240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I39_15245	COG0489	protein tyrosine kinase activity
I6I39_15250	COG0572	uridine kinase
I6I39_15260	COG2982	Protein involved in outer membrane biogenesis
I6I39_15265	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I39_15270	COG1253	flavin adenine dinucleotide binding
I6I39_15315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_15345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I39_15350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I39_15355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I39_15360	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I39_15360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I39_15365	COG0107	imidazoleglycerol-phosphate synthase activity
I6I39_15370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I39_15380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I39_15380	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I39_15385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I39_15395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I39_15405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_15410	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_15425	COG0371	Dehydrogenase
I6I39_15430	COG0531	amino acid
I6I39_15435	COG2925	Exonuclease
I6I39_15440	COG3320	Male sterility
I6I39_15440	COG1022	Amp-dependent synthetase and ligase
I6I39_15445	COG1289	transmembrane transporter activity
I6I39_15450	COG2926	Belongs to the UPF0265 family
I6I39_15460	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_15465	COG1129	ABC transporter
I6I39_15480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I39_15490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I39_15510	COG4656	Part of a membrane complex involved in electron transport
I6I39_15520	COG1012	belongs to the aldehyde dehydrogenase family
I6I39_15530	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6I39_15605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6I39_15615	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6I39_15680	COG1492	cobalamin metabolic process
I6I39_15700	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I39_15765	COG3121	Chaperone
I6I39_15770	COG3188	usher protein
I6I39_15845	COG0137	argininosuccinate synthase activity
I6I39_15850	COG0534	Mate efflux family protein
I6I39_15860	COG0352	thiamine-phosphate diphosphorylase activity
I6I39_15865	COG0561	phosphatase activity
I6I39_15870	COG1349	DNA-binding transcription factor activity
I6I39_15880	COG0784	Response regulator, receiver
I6I39_15880	COG0835	chemotaxis
I6I39_15890	COG4221	oxidoreductase activity
I6I39_15915	COG3842	ATPase activity
I6I39_15925	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I39_15930	COG2271	Major facilitator Superfamily
I6I39_15945	COG4565	transcriptional regulatory protein
I6I39_15950	COG3290	protein histidine kinase activity
I6I39_15955	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6I39_15960	COG3052	prosthetic group binding
I6I39_15965	COG2301	Belongs to the HpcH HpaI aldolase family
I6I39_15970	COG3051	citrate lyase alpha subunit
I6I39_15975	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
I6I39_15975	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6I39_15985	COG0471	metal ion transport
I6I39_16000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I39_16015	COG2814	Major facilitator Superfamily
I6I39_16020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_16020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_16025	COG3122	Protein conserved in bacteria
I6I39_16045	COG3121	Chaperone
I6I39_16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_16070	COG2205	protein histidine kinase activity
I6I39_16135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I39_16140	COG0583	DNA-binding transcription factor activity
I6I39_16145	COG0582	viral genome integration into host DNA
I6I39_16155	COG3228	Belongs to the MtfA family
I6I39_16165	COG1070	Carbohydrate kinase
I6I39_16170	COG1070	Carbohydrate kinase
I6I39_16195	COG3121	Chaperone
I6I39_16215	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I39_16220	COG2943	transferase activity, transferring hexosyl groups
I6I39_16240	COG2259	Doxx family
I6I39_16250	COG1560	Kdo2-lipid A biosynthetic process
I6I39_16285	COG1054	Belongs to the UPF0176 family
I6I39_16290	COG0628	permease
I6I39_16320	COG0418	dihydroorotase activity
I6I39_16325	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I39_16330	COG1530	ribonuclease E activity
I6I39_16330	COG1530	ribonuclease E activity
I6I39_16335	COG0564	pseudouridine synthase activity
I6I39_16340	COG0424	maF-like protein
I6I39_16345	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I39_16350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I39_16355	COG0416	fatty acid biosynthetic process
I6I39_16360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I39_16365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I39_16370	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_16380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I39_16385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I39_16390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I39_16395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I39_16400	COG0470	DNA polymerase III
I6I39_16405	COG0084	hydrolase, TatD family'
I6I39_16410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_16410	COG1263	PTS System
I6I39_16430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I39_16435	COG0537	adenosine 5'-monophosphoramidase activity
I6I39_16440	COG5633	Lipoprotein
I6I39_16445	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6I39_16455	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I39_16460	COG3150	esterase
I6I39_16465	COG1252	NADH dehydrogenase
I6I39_16470	COG3134	Outer membrane lipoprotein
I6I39_16475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I39_16480	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I39_16490	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I39_16495	COG1940	carbohydrate kinase activity
I6I39_16510	COG2850	peptidyl-arginine hydroxylation
I6I39_16520	COG0745	RESPONSE REGULATOR receiver
I6I39_16530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I39_16535	COG2915	High frequency lysogenization protein hflD homolog
I6I39_16540	COG0482	sulfurtransferase activity
I6I39_16550	COG1187	pseudouridine synthase activity
I6I39_16555	COG0538	isocitrate dehydrogenase activity
I6I39_16585	COG0538	isocitrate dehydrogenase activity
I6I39_16625	COG0840	transmembrane signaling receptor activity
I6I39_16645	COG2873	o-acetylhomoserine
I6I39_16650	COG0702	epimerase
I6I39_16655	COG1733	regulation of RNA biosynthetic process
I6I39_16690	COG3755	Protein conserved in bacteria
I6I39_16705	COG4251	negative regulation of phosphorylation
I6I39_16705	COG5001	Diguanylate cyclase
I6I39_16705	COG3706	GGDEF domain
I6I39_16705	COG2203	Gaf domain
I6I39_16725	COG1132	(ABC) transporter
I6I39_16745	COG2207	Transcriptional regulator
I6I39_16750	COG3328	transposase activity
I6I39_16785	COG1113	amino acid transport
I6I39_16805	COG1496	oxidoreductase activity
I6I39_16825	COG4811	Protein of unknown function (DUF986)
I6I39_16830	COG3716	PTS system mannose fructose sorbose family IID component
I6I39_16835	COG3715	PTS system
I6I39_16840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_16840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_16845	COG1253	flavin adenine dinucleotide binding
I6I39_16855	COG1760	l-serine dehydratase
I6I39_16860	COG0494	nUDIX hydrolase
I6I39_16870	COG3140	Belongs to the UPF0181 family
I6I39_16875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I39_16880	COG0513	Belongs to the DEAD box helicase family
I6I39_16885	COG3141	response to X-ray
I6I39_16890	COG3097	Belongs to the UPF0267 family
I6I39_16900	COG1770	oligopeptidase
I6I39_16905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I39_16920	COG1528	Iron-storage protein
I6I39_16925	COG2372	response to copper ion
I6I39_16930	COG1276	copper resistance
I6I39_16940	COG4974	Belongs to the 'phage' integrase family
I6I39_16990	COG3328	transposase activity
I6I39_16995	COG0500	methyltransferase
I6I39_17005	COG3328	transposase activity
I6I39_17010	COG0561	phosphatase activity
I6I39_17015	COG2223	nitrite transmembrane transporter activity
I6I39_17045	COG0672	)-iron permease
I6I39_17060	COG1136	(ABC) transporter
I6I39_17060	COG0577	efflux transmembrane transporter activity
I6I39_17070	COG1136	(ABC) transporter
I6I39_17070	COG0577	efflux transmembrane transporter activity
I6I39_17095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I39_17100	COG4114	ferric iron reductase
I6I39_17105	COG0006	proline dipeptidase activity
I6I39_17115	COG0726	polysaccharide deacetylase
I6I39_17115	COG1649	PFAM Uncharacterised BCR, COG1649
I6I39_17120	COG1215	transferase activity, transferring glycosyl groups
I6I39_17125	COG3658	cytochrome
I6I39_17135	COG1702	phosphate starvation-inducible protein PhoH
I6I39_17145	COG0018	arginyl-trna synthetase
I6I39_17150	COG3102	Protein conserved in bacteria
I6I39_17155	COG3142	Participates in the control of copper homeostasis
I6I39_17175	COG0668	transmembrane transport
I6I39_17180	COG0625	glutathione transferase activity
I6I39_17205	COG5001	Diguanylate cyclase
I6I39_17240	COG2814	Major facilitator Superfamily
I6I39_17250	COG3008	intermembrane lipid transfer
I6I39_17255	COG2995	paraquat-inducible protein a
I6I39_17260	COG1956	GAF domain-containing protein
I6I39_17270	COG0793	Belongs to the peptidase S41A family
I6I39_17275	COG0501	Belongs to the peptidase M48B family
I6I39_17285	COG2814	Major facilitator Superfamily
I6I39_17290	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_17300	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I39_17310	COG1823	symporter activity
I6I39_17315	COG1988	membrane-bound metal-dependent
I6I39_17320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I39_17325	COG1653	transport
I6I39_17330	COG3842	ATPase activity
I6I39_17335	COG0395	ABC-type sugar transport system, permease component
I6I39_17340	COG1175	transmembrane transport
I6I39_17350	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_17355	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6I39_17360	COG1917	Cupin 2, conserved barrel domain protein
I6I39_17365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I39_17375	COG0583	DNA-binding transcription factor activity
I6I39_17380	COG0427	acetyl-CoA hydrolase
I6I39_17385	COG1024	Enoyl-CoA hydratase
I6I39_17390	COG1703	isobutyryl-CoA mutase activity
I6I39_17395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I39_17395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I39_17400	COG3001	Fructosamine kinase
I6I39_17405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_17410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_17415	COG1121	(ABC) transporter
I6I39_17420	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I39_17450	COG1811	Na channel or pump
I6I39_17455	COG4249	Peptidase C14 caspase catalytic subunit p20
I6I39_17460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I39_17465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I39_17470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I39_17475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I39_17485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I39_17495	COG0776	regulation of translation
I6I39_17500	COG2314	TM2 domain
I6I39_17510	COG4139	cobalamin transport
I6I39_17515	COG0386	Belongs to the glutathione peroxidase family
I6I39_17520	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6I39_17525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I39_17530	COG0463	Glycosyl transferase, family 2
I6I39_17535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I39_17535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I39_17540	COG0726	polysaccharide deacetylase
I6I39_17545	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I39_17550	COG2076	Multidrug Resistance protein
I6I39_17555	COG2076	Multidrug Resistance protein
I6I39_17560	COG0791	NLP P60 protein
I6I39_17565	COG0095	Lipoate-protein ligase
I6I39_17575	COG4558	Periplasmic binding protein
I6I39_17580	COG3720	iron ion transport
I6I39_17600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I39_17605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I39_17605	COG0574	Belongs to the PEP-utilizing enzyme family
I6I39_17615	COG0628	permease
I6I39_17620	COG0247	lactate metabolic process
I6I39_17620	COG0277	FAD linked oxidase domain protein
I6I39_17625	COG2050	protein possibly involved in aromatic compounds catabolism
I6I39_17630	COG0316	Belongs to the HesB IscA family
I6I39_17635	COG0719	Fe-S assembly protein
I6I39_17640	COG0396	ATPase activity
I6I39_17645	COG0719	Fe-S assembly protein
I6I39_17655	COG2166	iron-sulfur cluster assembly
I6I39_17660	COG1388	LysM domain
I6I39_17660	COG1376	ErfK ybiS ycfS ynhG family protein
I6I39_17685	COG0534	Mate efflux family protein
I6I39_17690	COG0307	riboflavin synthase, alpha
I6I39_17695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I39_17700	COG2814	Major facilitator Superfamily
I6I39_17705	COG0583	DNA-binding transcription factor activity
I6I39_17710	COG1609	Transcriptional regulator
I6I39_17725	COG0791	NLP P60 protein
I6I39_17730	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I39_17740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I39_17750	COG0346	lactoylglutathione lyase activity
I6I39_17755	COG1902	pentaerythritol trinitrate reductase activity
I6I39_17760	COG1309	transcriptional regulator
I6I39_17765	COG2194	sulfuric ester hydrolase activity
I6I39_17770	COG3313	Fe-S protein
I6I39_17775	COG4989	oxidoreductase activity
I6I39_17780	COG1289	transmembrane transporter activity
I6I39_17785	COG1566	PFAM secretion protein HlyD family protein
I6I39_17795	COG1846	Transcriptional regulator
I6I39_17800	COG3133	Outer membrane lipoprotein
I6I39_17805	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I39_17810	COG3895	Periplasmic Protein
I6I39_17815	COG0259	pyridoxamine-phosphate oxidase activity
I6I39_17820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I39_17830	COG0625	glutathione transferase activity
I6I39_17850	COG3104	oligopeptide transport
I6I39_17865	COG4172	Belongs to the ABC transporter superfamily
I6I39_17875	COG4171	peptide transport system, permease
I6I39_17880	COG4168	peptide transport system, permease
I6I39_17885	COG4166	transmembrane transport
I6I39_17910	COG1349	DNA-binding transcription factor activity
I6I39_17915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I39_17920	COG2879	small protein
I6I39_17925	COG1966	Carbon starvation protein
I6I39_17935	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6I39_17940	COG0243	molybdopterin cofactor binding
I6I39_17960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I39_17970	COG4659	FMN binding
I6I39_17975	COG4658	electron transport chain
I6I39_17980	COG2207	Transcriptional regulator
I6I39_17980	COG3708	Transcriptional regulator
I6I39_17990	COG4656	Part of a membrane complex involved in electron transport
I6I39_18000	COG4657	Part of a membrane complex involved in electron transport
I6I39_18010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I39_18025	COG2274	protein secretion by the type I secretion system
I6I39_18030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I39_18035	COG2160	L-arabinose isomerase activity
I6I39_18045	COG1879	ABC-type sugar transport system periplasmic component
I6I39_18050	COG1129	ABC transporter
I6I39_18055	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I39_18065	COG0673	inositol 2-dehydrogenase activity
I6I39_18070	COG0385	Bile acid
I6I39_18075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I39_18080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I39_18100	COG5339	Protein conserved in bacteria
I6I39_18110	COG0114	fumarate hydratase activity
I6I39_18140	COG2814	Major facilitator Superfamily
I6I39_18145	COG0583	DNA-binding transcription factor activity
I6I39_18150	COG1940	carbohydrate kinase activity
I6I39_18155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I39_18185	COG1742	UPF0060 membrane protein
I6I39_18190	COG4221	oxidoreductase activity
I6I39_18300	COG4128	Pfam Zonular occludens toxin
I6I39_18325	COG0625	glutathione transferase activity
I6I39_18350	COG1522	sequence-specific DNA binding
I6I39_18385	COG3177	Filamentation induced by cAMP protein fic
I6I39_18395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I39_18405	COG0483	inositol monophosphate 1-phosphatase activity
I6I39_18440	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I39_18450	COG0028	Belongs to the TPP enzyme family
I6I39_18455	COG0440	acetolactate synthase activity
I6I39_18460	COG1011	Hydrolase
I6I39_18475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I39_18485	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_18490	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I39_18505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I39_18510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I39_18515	COG0589	response to stress
I6I39_18520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I39_18525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I39_18535	COG0531	amino acid
I6I39_18545	COG0745	RESPONSE REGULATOR receiver
I6I39_18550	COG2205	protein histidine kinase activity
I6I39_18555	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I39_18565	COG3591	Belongs to the peptidase S1B family
I6I39_18580	COG1643	Atp-dependent helicase
I6I39_18585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I39_18590	COG3784	Protein of unknown function (DUF1318)
I6I39_18600	COG2911	Protein conserved in bacteria
I6I39_18605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I39_18610	COG3042	response to heat
I6I39_18615	COG1285	pathogenesis
I6I39_18625	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I39_18625	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I39_18625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I39_18625	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I39_18630	COG0823	Involved in the tonB-independent uptake of proteins
I6I39_18635	COG0037	tRNA processing
I6I39_18640	COG0598	Magnesium transport protein CorA
I6I39_18645	COG4166	transmembrane transport
I6I39_18650	COG2866	Carboxypeptidase
I6I39_18655	COG4948	Mandelate Racemase Muconate Lactonizing
I6I39_18660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I39_18670	COG5642	Protein of unknown function (DUF2384)
I6I39_18675	COG5654	RES domain protein
I6I39_18680	COG3768	UPF0283 membrane protein
I6I39_18685	COG3106	COG3106 Predicted ATPase
I6I39_18695	COG1983	PspC domain protein
I6I39_18705	COG1842	Phage shock protein A
I6I39_18710	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I39_18730	COG0023	Translation Initiation Factor
I6I39_18735	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I39_18750	COG1396	sequence-specific DNA binding
I6I39_18760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I39_18765	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6I39_18770	COG0671	phosphoesterase, PA-phosphatase related
I6I39_18790	COG0583	DNA-binding transcription factor activity
I6I39_18805	COG0616	signal peptide processing
I6I39_18810	COG1028	Short-chain dehydrogenase reductase Sdr
I6I39_18815	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6I39_18825	COG1187	pseudouridine synthase activity
I6I39_18830	COG0009	L-threonylcarbamoyladenylate synthase
I6I39_18835	COG0613	PHP domain protein
I6I39_18850	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I39_18860	COG0134	indole-3-glycerol-phosphate synthase activity
I6I39_18860	COG0135	phosphoribosylanthranilate isomerase activity
I6I39_18865	COG0133	tryptophan synthase activity
I6I39_18870	COG0159	tryptophan synthase activity
I6I39_18880	COG3047	cAMP biosynthetic process
I6I39_18885	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6I39_18900	COG2917	probably involved in intracellular septation
I6I39_18905	COG1607	acyl-coa hydrolase
I6I39_18910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6I39_18915	COG2350	Protein conserved in bacteria
I6I39_18940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I39_18945	COG3099	Belongs to the UPF0263 family
I6I39_18955	COG0444	Belongs to the ABC transporter superfamily
I6I39_18960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I39_18980	COG2095	MarC family integral membrane protein
I6I39_18985	COG1454	alcohol dehydrogenase
I6I39_18985	COG1012	belongs to the aldehyde dehydrogenase family
I6I39_18995	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6I39_19010	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I39_19020	COG3012	SEC-C Motif Domain Protein
I6I39_19025	COG0788	formyltetrahydrofolate deformylase activity
I6I39_19040	COG0583	DNA-binding transcription factor activity
I6I39_19045	COG0708	Exodeoxyribonuclease III
I6I39_19050	COG0494	nUDIX hydrolase
I6I39_19060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I39_19070	COG0778	Nitroreductase
I6I39_19075	COG0616	signal peptide processing
I6I39_19080	COG0252	asparaginase activity
I6I39_19085	COG1335	isochorismatase
I6I39_19095	COG3139	Protein of unknown function (DUF1315)
I6I39_19100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I39_19115	COG3713	MltA-interacting MipA family protein
I6I39_19120	COG2766	serine protein kinase
I6I39_19125	COG2718	Belongs to the UPF0229 family
I6I39_19140	COG0583	DNA-binding transcription factor activity
I6I39_19150	COG2199	diguanylate cyclase activity
I6I39_19150	COG2202	Pas domain
I6I39_19150	COG2200	EAL domain
I6I39_19155	COG2814	Major facilitator Superfamily
I6I39_19160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I39_19165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I39_19170	COG2719	SpoVR family
I6I39_19175	COG2186	Transcriptional regulator
I6I39_19180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I39_19185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I39_19205	COG2983	Belongs to the UPF0260 family
I6I39_19210	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I39_19215	COG2951	lytic endotransglycosylase activity
I6I39_19220	COG3100	YcgL domain-containing protein
I6I39_19230	COG0850	regulation of cytokinetic process
I6I39_19235	COG2894	cell division
I6I39_19240	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I39_19245	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I39_19250	COG0318	PFAM AMP-dependent synthetase and ligase
I6I39_19255	COG3065	identical protein binding
I6I39_19265	COG1199	ATP-dependent helicase activity
I6I39_19270	COG0251	oxidation-reduction process
I6I39_19275	COG2076	Multidrug Resistance protein
I6I39_19280	COG2076	Multidrug Resistance protein
I6I39_19285	COG0800	Aldolase
I6I39_19290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I39_19295	COG1737	Transcriptional regulator
I6I39_19300	COG0469	pyruvate kinase activity
I6I39_19310	COG1560	Kdo2-lipid A biosynthetic process
I6I39_19315	COG0739	heme binding
I6I39_19320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6I39_19325	COG1121	(ABC) transporter
I6I39_19330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I39_19335	COG3104	oligopeptide transport
I6I39_19340	COG2255	four-way junction helicase activity
I6I39_19345	COG0632	four-way junction helicase activity
I6I39_19350	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I39_19355	COG0217	transcriptional regulatory protein
I6I39_19360	COG0494	nUDIX hydrolase
I6I39_19365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I39_19375	COG1335	isochorismatase
I6I39_19380	COG1801	Protein of unknown function DUF72
I6I39_19385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6I39_19390	COG2226	methyltransferase
I6I39_19395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I39_19410	COG0786	glutamate:sodium symporter activity
I6I39_19415	COG1187	pseudouridine synthase activity
I6I39_19435	COG1349	DNA-binding transcription factor activity
I6I39_19445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I39_19455	COG3716	PTS system mannose fructose sorbose family IID component
I6I39_19460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I39_19465	COG2222	sugar isomerase
I6I39_19475	COG4942	peptidase
I6I39_19500	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I39_19510	COG0402	S-adenosylhomocysteine deaminase activity
I6I39_19520	COG1228	amidohydrolase
I6I39_19545	COG2988	succinylglutamate desuccinylase activity
I6I39_19550	COG3724	N-succinylarginine dihydrolase activity
I6I39_19560	COG3138	arginine N-succinyltransferase
I6I39_19565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I39_19570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I39_19575	COG1271	oxidase subunit
I6I39_19580	COG1294	oxidase, subunit
I6I39_19590	COG3850	Histidine kinase
I6I39_19595	COG0583	DNA-binding transcription factor activity
I6I39_19605	COG2814	Major facilitator Superfamily
I6I39_19615	COG0387	Pfam Sodium calcium exchanger
I6I39_19620	COG0728	peptidoglycan biosynthetic process
I6I39_19625	COG0673	inositol 2-dehydrogenase activity
I6I39_19635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I39_19650	COG0477	Major facilitator Superfamily
I6I39_19660	COG3381	protein complex oligomerization
I6I39_19665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I39_19670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I39_19690	COG3706	GGDEF domain
I6I39_19695	COG0659	secondary active sulfate transmembrane transporter activity
I6I39_19700	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I39_19715	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I39_19720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I39_19725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I39_19730	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I39_19740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I39_19750	COG0193	aminoacyl-tRNA hydrolase activity
I6I39_19760	COG0012	GTP binding
I6I39_19775	COG2979	Protein of unknown function (DUF533)
I6I39_19780	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I39_19785	COG3772	lysozyme
I6I39_19915	COG3041	Addiction module toxin RelE StbE family
I6I39_19920	COG3077	Addiction module antitoxin, RelB DinJ family
I6I39_19975	COG4974	Belongs to the 'phage' integrase family
I6I39_20040	COG4695	Portal protein
I6I39_20190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I39_20195	COG0322	excinuclease ABC activity
I6I39_20200	COG2197	response regulator
I6I39_20210	COG3136	membrane protein required for alginate biosynthesis
I6I39_20220	COG0366	Alpha amylase catalytic
I6I39_20235	COG2226	methyltransferase
I6I39_20255	COG1113	amino acid transport
I6I39_20260	COG1309	transcriptional regulator
I6I39_20270	COG1335	isochorismatase
I6I39_20275	COG0251	oxidation-reduction process
I6I39_20280	COG2267	carboxylic ester hydrolase activity
I6I39_20285	COG0778	Nitroreductase
I6I39_20290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I39_20300	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6I39_20310	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I39_20320	COG2822	iron ion transport
I6I39_20325	COG0672	)-iron permease
I6I39_20330	COG3157	Type VI secretion system effector, Hcp
I6I39_20345	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I39_20345	COG0506	proline dehydrogenase activity
I6I39_20345	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I39_20360	COG1126	abc transporter atp-binding protein
I6I39_20365	COG0765	amino acid transport
I6I39_20370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I39_20375	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I39_20385	COG1191	sigma factor activity
I6I39_20430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6I39_20435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I39_20455	COG0582	viral genome integration into host DNA
I6I39_20460	COG1677	Flagellar hook-basal body complex protein FliE
I6I39_20475	COG1317	bacterial-type flagellum organization
I6I39_20495	COG1580	Controls the rotational direction of flagella during chemotaxis