locus-tag	class	description
I6I47_00010	COG2011	ABC-type metal ion transport system permease component
I6I47_00035	COG0625	glutathione transferase activity
I6I47_00040	COG4771	TonB-dependent receptor
I6I47_00050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I47_00055	COG0833	amino acid
I6I47_00060	COG0583	DNA-binding transcription factor activity
I6I47_00075	COG2855	membrane
I6I47_00080	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I47_00105	COG3710	Transcriptional regulator
I6I47_00110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I47_00110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I47_00110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I47_00115	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I47_00130	COG3005	denitrification pathway
I6I47_00135	COG0243	molybdopterin cofactor binding
I6I47_00150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I47_00155	COG1312	Catalyzes the dehydration of D-mannonate
I6I47_00165	COG0246	Mannitol dehydrogenase
I6I47_00170	COG2186	Transcriptional regulator
I6I47_00180	COG0523	cobalamin synthesis protein
I6I47_00185	COG0671	phosphoesterase, PA-phosphatase related
I6I47_00190	COG0791	NLP P60 protein
I6I47_00195	COG2200	EAL domain
I6I47_00200	COG4166	transmembrane transport
I6I47_00205	COG4174	ABC transporter (Permease)
I6I47_00210	COG4239	(ABC) transporter, permease
I6I47_00215	COG4172	Belongs to the ABC transporter superfamily
I6I47_00225	COG2814	Major facilitator Superfamily
I6I47_00230	COG1187	pseudouridine synthase activity
I6I47_00235	COG1061	Type III restriction enzyme res subunit
I6I47_00240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I47_00245	COG3081	Nucleoid-associated protein
I6I47_00250	COG3082	Protein of unknown function (DUF1414)
I6I47_00275	COG3328	transposase activity
I6I47_00285	COG2963	transposase activity
I6I47_00290	COG2801	Transposase and inactivated derivatives
I6I47_00310	COG3328	transposase activity
I6I47_00320	COG2723	6-phospho-beta-galactosidase activity
I6I47_00325	COG1263	PTS System
I6I47_00325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_00325	COG2190	(PTS) system
I6I47_00330	COG1737	Transcriptional regulator
I6I47_00390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I47_00405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I47_00415	COG2223	nitrite transmembrane transporter activity
I6I47_00420	COG2198	Histidine kinase
I6I47_00420	COG0642	Histidine kinase
I6I47_00425	COG2197	response regulator
I6I47_00430	COG2205	protein histidine kinase activity
I6I47_00430	COG0784	Response regulator, receiver
I6I47_00440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I47_00445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I47_00455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I47_00460	COG4574	serine-type endopeptidase inhibitor activity
I6I47_00490	COG0814	amino acid
I6I47_00510	COG1441	menaquinone biosynthetic process
I6I47_00515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I47_00520	COG0596	Alpha beta hydrolase
I6I47_00525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I47_00530	COG1169	isochorismate synthase
I6I47_00535	COG4575	ribosome binding
I6I47_00540	COG0129	dihydroxy-acid dehydratase activity
I6I47_00545	COG4702	Belongs to the UPF0303 family
I6I47_00555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I47_00560	COG1609	Transcriptional regulator
I6I47_00565	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_00570	COG3265	gluconokinase activity
I6I47_00590	COG1007	ATP synthesis coupled electron transport
I6I47_00595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_00600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I47_00605	COG0713	ATP synthesis coupled electron transport
I6I47_00610	COG0839	Belongs to the complex I subunit 6 family
I6I47_00615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_00620	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I47_00625	COG1034	ATP synthesis coupled electron transport
I6I47_00640	COG0649	NAD binding
I6I47_00640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_00645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_00650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_00655	COG0583	DNA-binding transcription factor activity
I6I47_00660	COG0436	Aminotransferase
I6I47_00665	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I47_00670	COG0471	metal ion transport
I6I47_00670	COG0490	domain, Protein
I6I47_00680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I47_00685	COG3013	Belongs to the UPF0304 family
I6I47_00690	COG3092	negative regulation of chromosome organization
I6I47_00700	COG0280	phosphate acetyltransferase
I6I47_00700	COG0857	belongs to the CobB CobQ family
I6I47_00705	COG1609	Transcriptional regulator
I6I47_00710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_00720	COG3037	sugar-specific permease SgaT UlaA
I6I47_00730	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I47_00735	COG0622	Phosphoesterase
I6I47_00745	COG1090	epimerase
I6I47_00760	COG4598	ABC transporter
I6I47_00765	COG4160	amino acid transport
I6I47_00770	COG4215	(ABC) transporter
I6I47_00775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_00780	COG0163	prenyltransferase activity
I6I47_00785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I47_00790	COG1286	toxin biosynthetic process
I6I47_00795	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6I47_00800	COG0285	dihydrofolate synthase activity
I6I47_00805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I47_00810	COG0586	Pfam SNARE associated Golgi protein
I6I47_00820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I47_00825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I47_00835	COG0697	spore germination
I6I47_00850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I47_00855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I47_00880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I47_00890	COG1609	Transcriptional regulator
I6I47_00900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I47_00905	COG2723	6-phospho-beta-galactosidase activity
I6I47_00910	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I47_00920	COG1794	racemase activity, acting on amino acids and derivatives
I6I47_00925	COG3706	GGDEF domain
I6I47_00930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I47_00935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I47_00935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I47_00945	COG3101	peptidyl-lysine hydroxylation
I6I47_00950	COG0730	response to heat
I6I47_00955	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6I47_00960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I47_00965	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I47_00970	COG2840	Smr protein MutS2
I6I47_00975	COG2062	phosphohistidine phosphatase, SixA
I6I47_00980	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I47_00980	COG1024	Enoyl-CoA hydratase
I6I47_00985	COG0183	Belongs to the thiolase family
I6I47_00990	COG3691	Protein conserved in bacteria
I6I47_01005	COG4235	cytochrome complex assembly
I6I47_01005	COG3088	subunit of a heme lyase
I6I47_01015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I47_01020	COG1138	Cytochrome C-type biogenesis protein
I6I47_01025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I47_01030	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I47_01035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I47_01040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I47_01055	COG2116	formate transmembrane transporter activity
I6I47_01075	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I47_01080	COG1695	Transcriptional regulator
I6I47_01090	COG2723	6-phospho-beta-galactosidase activity
I6I47_01095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_01095	COG1263	PTS System
I6I47_01100	COG1609	Transcriptional regulator
I6I47_01105	COG2353	YceI-like domain
I6I47_01110	COG3038	cytochrome b561
I6I47_01130	COG1127	ABC transporter
I6I47_01135	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I47_01155	COG0531	amino acid
I6I47_01160	COG2951	lytic endotransglycosylase activity
I6I47_01180	COG1280	lysine exporter protein (LysE YggA)
I6I47_01190	COG1598	PFAM Uncharacterised protein family UPF0150
I6I47_01200	COG3038	cytochrome b561
I6I47_01205	COG0436	Aminotransferase
I6I47_01220	COG3275	phosphorelay sensor kinase activity
I6I47_01225	COG3279	Response regulator of the LytR AlgR family
I6I47_01230	COG2223	nitrite transmembrane transporter activity
I6I47_01235	COG0837	glucose binding
I6I47_01250	COG3961	Belongs to the TPP enzyme family
I6I47_01255	COG0667	Aldo Keto reductase
I6I47_01265	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I47_01270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I47_01300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I47_01325	COG3328	transposase activity
I6I47_01330	COG3530	Putative quorum-sensing-regulated virulence factor
I6I47_01335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I47_01355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_01360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I47_01370	COG2205	protein histidine kinase activity
I6I47_01375	COG0745	RESPONSE REGULATOR receiver
I6I47_01380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_01400	COG4208	sulfate ABC transporter
I6I47_01405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I47_01410	COG4150	thiosulfate binding
I6I47_01420	COG1737	Transcriptional regulator
I6I47_01425	COG2731	YhcH YjgK YiaL family protein
I6I47_01440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I47_01445	COG2837	iron assimilation
I6I47_01455	COG3111	PFAM Bacterial OB fold (BOF) protein
I6I47_01460	COG0456	acetyltransferase
I6I47_01465	COG0408	coproporphyrinogen oxidase activity
I6I47_01470	COG1671	Belongs to the UPF0178 family
I6I47_01490	COG0280	phosphate acetyltransferase
I6I47_01490	COG0281	malic enzyme
I6I47_01495	COG0494	nUDIX hydrolase
I6I47_01500	COG3005	denitrification pathway
I6I47_01505	COG3043	anaerobic respiration
I6I47_01510	COG0243	molybdopterin cofactor binding
I6I47_01515	COG3062	negative regulation of establishment of protein localization
I6I47_01525	COG2197	response regulator
I6I47_01535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I47_01550	COG1393	Belongs to the ArsC family
I6I47_01555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I47_01560	COG1876	peptidase activity
I6I47_01610	COG0400	carboxylic ester hydrolase activity
I6I47_01625	COG1444	tRNA N-acetyltransferase activity
I6I47_01630	COG2707	UPF0756 membrane protein
I6I47_01635	COG2321	neutral zinc metallopeptidase
I6I47_01640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I47_01645	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I47_01650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I47_01655	COG2716	regulation of RNA biosynthetic process
I6I47_01660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I47_01665	COG0628	permease
I6I47_01670	COG4783	chaperone-mediated protein folding
I6I47_01675	COG1393	Belongs to the ArsC family
I6I47_01680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I47_01685	COG2233	PERMEase
I6I47_01690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I47_01695	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I47_01700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I47_01705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I47_01720	COG0581	inorganic phosphate transmembrane transporter activity
I6I47_01725	COG0573	inorganic phosphate transmembrane transporter activity
I6I47_01730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I47_01745	COG2239	Acts as a magnesium transporter
I6I47_01750	COG3447	MASE1 domain protein
I6I47_01750	COG5002	protein histidine kinase activity
I6I47_01750	COG5001	Diguanylate cyclase
I6I47_01755	COG0443	Heat shock 70 kDa protein
I6I47_01765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_01775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I47_01780	COG0477	Major facilitator Superfamily
I6I47_01785	COG2205	protein histidine kinase activity
I6I47_01790	COG0745	RESPONSE REGULATOR receiver
I6I47_01795	COG3422	double-strand break repair
I6I47_01800	COG0826	peptidase U32
I6I47_01805	COG1597	lipid kinase activity
I6I47_01810	COG3730	PTS system glucitol sorbitol-specific
I6I47_01825	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_01830	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_01835	COG1349	DNA-binding transcription factor activity
I6I47_01855	COG0351	phosphomethylpyrimidine kinase
I6I47_01890	COG0519	Catalyzes the synthesis of GMP from XMP
I6I47_01890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I47_01895	COG0517	IMP dehydrogenase activity
I6I47_01895	COG0516	GMP reductase activity
I6I47_01900	COG1570	exodeoxyribonuclease VII activity
I6I47_01905	COG1645	bacterial-type flagellum-dependent swarming motility
I6I47_01920	COG1160	GTP binding
I6I47_01925	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I47_01930	COG2976	Protein conserved in bacteria
I6I47_01935	COG0124	histidyl-tRNA synthetase
I6I47_01940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I47_01945	COG1426	Protein conserved in bacteria
I6I47_01955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I47_01970	COG4953	penicillin-binding protein 1C
I6I47_01975	COG2373	Large extracellular alpha-helical protein
I6I47_01980	COG3468	outer membrane autotransporter barrel domain protein
I6I47_01995	COG2975	iron-sulfur cluster assembly
I6I47_02000	COG0633	Ferredoxin
I6I47_02005	COG0443	Heat shock 70 kDa protein
I6I47_02010	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I47_02015	COG0316	Belongs to the HesB IscA family
I6I47_02020	COG0822	iron-sulfur transferase activity
I6I47_02030	COG1959	2 iron, 2 sulfur cluster binding
I6I47_02035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6I47_02045	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I47_02050	COG3683	transport system, periplasmic component
I6I47_02055	COG3711	transcriptional antiterminator
I6I47_02060	COG2814	Major facilitator Superfamily
I6I47_02065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I47_02070	COG1017	nitric oxide dioxygenase activity
I6I47_02070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I47_02075	COG2188	Transcriptional regulator
I6I47_02085	COG3457	Alanine racemase
I6I47_02090	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6I47_02105	COG0347	Belongs to the P(II) protein family
I6I47_02110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I47_02110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I47_02115	COG2204	response regulator
I6I47_02120	COG3170	Tfp pilus assembly protein FimV
I6I47_02125	COG2205	protein histidine kinase activity
I6I47_02135	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6I47_02150	COG0560	Phosphoserine phosphatase
I6I47_02160	COG1737	Transcriptional regulator
I6I47_02165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I47_02170	COG2610	gluconate transmembrane transporter activity
I6I47_02175	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I47_02180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I47_02185	COG1381	Involved in DNA repair and RecF pathway recombination
I6I47_02190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I47_02195	COG0571	ribonuclease III activity
I6I47_02205	COG0481	GTPase activity
I6I47_02215	COG3086	response to oxidative stress
I6I47_02225	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6I47_02235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I47_02240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I47_02245	COG0513	Belongs to the DEAD box helicase family
I6I47_02265	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
I6I47_02270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I47_02275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I47_02280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I47_02285	COG0497	DNA recombination
I6I47_02290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I47_02300	COG2867	negative regulation of translational initiation
I6I47_02305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I47_02315	COG0582	viral genome integration into host DNA
I6I47_02345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I47_02400	COG3328	transposase activity
I6I47_02405	COG0659	secondary active sulfate transmembrane transporter activity
I6I47_02410	COG3394	polysaccharide catabolic process
I6I47_02415	COG2169	Transcriptional regulator
I6I47_02415	COG1917	Cupin 2, conserved barrel domain protein
I6I47_02420	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I47_02425	COG2723	6-phospho-beta-galactosidase activity
I6I47_02430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I47_02435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I47_02440	COG2133	pyrroloquinoline quinone binding
I6I47_02450	COG0667	Aldo Keto reductase
I6I47_02465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I47_02475	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I47_02480	COG4413	Urea transporter
I6I47_02485	COG0829	nickel cation binding
I6I47_02490	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I47_02495	COG0830	nickel cation binding
I6I47_02500	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I47_02505	COG0804	urea catabolic process
I6I47_02510	COG0832	Belongs to the urease beta subunit family
I6I47_02515	COG0831	urea catabolic process
I6I47_02520	COG1124	(ABC) transporter
I6I47_02530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I47_02565	COG1278	Cold shock
I6I47_02590	COG2207	Transcriptional regulator
I6I47_02605	COG4575	ribosome binding
I6I47_02615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I47_02625	COG1780	Probably involved in ribonucleotide reductase function
I6I47_02635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I47_02645	COG4176	ABC-type proline glycine betaine transport system permease component
I6I47_02650	COG2113	Glycine betaine
I6I47_02665	COG0328	RNA-DNA hybrid ribonuclease activity
I6I47_02670	COG2226	methyltransferase
I6I47_02675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I47_02680	COG0741	lytic transglycosylase activity
I6I47_02680	COG1388	LysM domain
I6I47_02690	COG3021	interspecies interaction between organisms
I6I47_02695	COG2814	Major facilitator Superfamily
I6I47_02700	COG0583	DNA-binding transcription factor activity
I6I47_02705	COG0656	L-ascorbic acid biosynthetic process
I6I47_02715	COG3328	transposase activity
I6I47_02745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I47_02755	COG2011	ABC-type metal ion transport system permease component
I6I47_02760	COG1464	Belongs to the NlpA lipoprotein family
I6I47_02770	COG1720	tRNA m6t6A37 methyltransferase activity
I6I47_02775	COG0442	prolyl-tRNA aminoacylation
I6I47_02780	COG3015	lipoprotein NlpE involved in copper resistance
I6I47_02790	COG4681	YaeQ
I6I47_02800	COG4568	rho-dependent transcription termination
I6I47_02815	COG0346	lactoylglutathione lyase activity
I6I47_02820	COG1982	Orn Lys Arg decarboxylase major
I6I47_02825	COG0825	malonyl-CoA metabolic process
I6I47_02835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I47_02845	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I47_02850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I47_02855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I47_02860	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I47_02870	COG0750	zinc metalloprotease
I6I47_02875	COG0575	Belongs to the CDS family
I6I47_02885	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I47_02890	COG0233	cytoplasmic translational termination
I6I47_02895	COG0528	UMP kinase activity
I6I47_02900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I47_02905	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I47_02915	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I47_02920	COG2171	N-acyltransferase activity
I6I47_02935	COG0564	pseudouridine synthase activity
I6I47_02940	COG3098	single-species biofilm formation
I6I47_02950	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I47_02950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I47_02955	COG1611	Belongs to the LOG family
I6I47_02960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I47_02965	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6I47_02970	COG2363	Small membrane protein
I6I47_02975	COG0583	DNA-binding transcription factor activity
I6I47_02985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I47_02990	COG2166	iron-sulfur cluster assembly
I6I47_02995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I47_03000	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I47_03020	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I47_03025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I47_03025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I47_03040	COG0191	fructose-bisphosphate aldolase activity
I6I47_03045	COG0126	phosphoglycerate kinase activity
I6I47_03050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I47_03055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I47_03060	COG0501	Belongs to the peptidase M48B family
I6I47_03070	COG1166	arginine decarboxylase activity
I6I47_03075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I47_03090	COG0640	Transcriptional regulator
I6I47_03095	COG3091	SprT-like family
I6I47_03100	COG2356	endonuclease I
I6I47_03105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I47_03110	COG0189	ligase activity
I6I47_03115	COG1678	Uncharacterized ACR, COG1678
I6I47_03120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I47_03125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I47_03135	COG2805	Type II/IV secretion system protein
I6I47_03140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I47_03145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I47_03150	COG0762	integral membrane protein
I6I47_03155	COG1872	DUF167
I6I47_03160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I47_03165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I47_03180	COG3171	Protein conserved in bacteria
I6I47_03185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I47_03190	COG1194	a g-specific adenine glycosylase
I6I47_03195	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I47_03200	COG0741	lytic transglycosylase activity
I6I47_03210	COG1982	Orn Lys Arg decarboxylase major
I6I47_03220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I47_03265	COG0531	amino acid
I6I47_03270	COG1982	Orn Lys Arg decarboxylase major
I6I47_03285	COG1289	transmembrane transporter activity
I6I47_03310	COG0024	Methionine aminopeptidase
I6I47_03315	COG4604	ABC transporter, ATP-binding protein
I6I47_03320	COG4605	iron ion homeostasis
I6I47_03330	COG4607	ABC-type enterochelin transport system periplasmic component
I6I47_03345	COG0697	spore germination
I6I47_03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I47_03355	COG0477	Major facilitator Superfamily
I6I47_03360	COG1609	Transcriptional regulator
I6I47_03370	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I47_03385	COG0477	Major facilitator Superfamily
I6I47_03400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_03405	COG5001	Diguanylate cyclase
I6I47_03415	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I47_03425	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6I47_03430	COG0309	Hydrogenase expression formation protein (HypE)
I6I47_03435	COG0409	Hydrogenase expression formation protein
I6I47_03440	COG0298	carbon dioxide binding
I6I47_03445	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I47_03455	COG1773	rubredoxin
I6I47_03460	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I47_03465	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6I47_03470	COG5557	Pfam Polysulphide reductase, NrfD
I6I47_03475	COG0437	4 iron, 4 sulfur cluster binding
I6I47_03480	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6I47_03485	COG3133	Outer membrane lipoprotein
I6I47_03495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I47_03500	COG1191	sigma factor activity
I6I47_03520	COG1516	flagellar protein fliS
I6I47_03525	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I47_03560	COG1706	bacterial-type flagellum-dependent cell motility
I6I47_03570	COG4786	Flagellar basal body rod
I6I47_03585	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I47_03590	COG1558	bacterial-type flagellum-dependent cell motility
I6I47_03595	COG1815	bacterial-type flagellum-dependent cell motility
I6I47_03645	COG1677	Flagellar hook-basal body complex protein FliE
I6I47_03670	COG1987	bacterial-type flagellum assembly
I6I47_03680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I47_03695	COG0840	transmembrane signaling receptor activity
I6I47_03700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I47_03705	COG2271	Major facilitator Superfamily
I6I47_03710	COG4592	Periplasmic binding protein
I6I47_03715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I47_03720	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I47_03725	COG1120	ATPase activity
I6I47_03745	COG0577	efflux transmembrane transporter activity
I6I47_03745	COG1136	(ABC) transporter
I6I47_03830	COG4964	Belongs to the GSP D family
I6I47_03880	COG0848	biopolymer transport protein
I6I47_03890	COG0626	cystathionine gamma-synthase activity
I6I47_03895	COG0586	Pfam SNARE associated Golgi protein
I6I47_03900	COG2207	Transcriptional regulator
I6I47_03905	COG1979	alcohol dehydrogenase
I6I47_03910	COG0656	L-ascorbic acid biosynthetic process
I6I47_03920	COG2132	Multicopper oxidase
I6I47_03930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I47_03935	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I47_03940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I47_03955	COG3150	esterase
I6I47_03960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I47_03965	COG3151	Protein conserved in bacteria
I6I47_03970	COG0494	nUDIX hydrolase
I6I47_03975	COG1538	Outer membrane efflux protein
I6I47_03980	COG5463	Belongs to the UPF0441 family
I6I47_03985	COG0754	glutathionylspermidine amidase activity
I6I47_03990	COG3384	dioxygenase
I6I47_03995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I47_04005	COG0531	amino acid
I6I47_04010	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I47_04010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I47_04015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I47_04020	COG3025	triphosphatase activity
I6I47_04025	COG4991	sh3 domain protein
I6I47_04030	COG0617	tRNA 3'-terminal CCA addition
I6I47_04035	COG1968	undecaprenyl-diphosphatase activity
I6I47_04040	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I47_04045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I47_04050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I47_04055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I47_04060	COG0358	DNA primase activity
I6I47_04200	COG4974	Belongs to the 'phage' integrase family
I6I47_04215	COG3876	Protein conserved in bacteria
I6I47_04225	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I47_04235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I47_04240	COG1263	PTS System
I6I47_04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_04250	COG0531	amino acid
I6I47_04255	COG0076	glutamate decarboxylase activity
I6I47_04260	COG3247	response to pH
I6I47_04270	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I47_04270	COG1902	pentaerythritol trinitrate reductase activity
I6I47_04280	COG2813	Specifically methylates the guanine in position
I6I47_04300	COG1451	nucleotide metabolic process
I6I47_04305	COG0673	inositol 2-dehydrogenase activity
I6I47_04310	COG0861	Integral membrane protein TerC family
I6I47_04315	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6I47_04325	COG2721	sulfolactate sulfo-lyase activity
I6I47_04330	COG0246	Mannitol dehydrogenase
I6I47_04335	COG1904	glucuronate isomerase
I6I47_04340	COG2271	Major facilitator Superfamily
I6I47_04355	COG0586	Pfam SNARE associated Golgi protein
I6I47_04370	COG4575	ribosome binding
I6I47_04375	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6I47_04385	COG2259	Doxx family
I6I47_04390	COG0435	Glutathione S-transferase
I6I47_04395	COG0583	DNA-binding transcription factor activity
I6I47_04400	COG1741	Belongs to the pirin family
I6I47_04405	COG1064	alcohol dehydrogenase
I6I47_04410	COG0667	Aldo Keto reductase
I6I47_04430	COG3121	Chaperone
I6I47_04445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I47_04455	COG0792	nuclease activity
I6I47_04460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I47_04465	COG2823	Periplasmic or secreted lipoprotein
I6I47_04470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I47_04475	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6I47_04480	COG5002	protein histidine kinase activity
I6I47_04480	COG2198	Histidine kinase
I6I47_04480	COG0784	Response regulator, receiver
I6I47_04485	COG1242	4 iron, 4 sulfur cluster binding
I6I47_04490	COG0070	glutamate synthase
I6I47_04490	COG0067	glutamate synthase
I6I47_04490	COG0069	glutamate synthase activity
I6I47_04495	COG0493	'glutamate synthase
I6I47_04505	COG2969	positive regulation of protein catabolic process
I6I47_04510	COG0625	glutathione transferase activity
I6I47_04515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I47_04520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I47_04525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I47_04530	COG3105	Protein conserved in bacteria
I6I47_04535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I47_04540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I47_04545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I47_04550	COG5007	Belongs to the BolA IbaG family
I6I47_04555	COG3113	response to antibiotic
I6I47_04560	COG2854	intermembrane phospholipid transfer
I6I47_04565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I47_04570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I47_04575	COG1127	ABC transporter
I6I47_04580	COG0530	calcium, potassium:sodium antiporter activity
I6I47_04585	COG0517	IMP dehydrogenase activity
I6I47_04585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I47_04590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I47_04595	COG3117	lipopolysaccharide transmembrane transporter activity
I6I47_04600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I47_04605	COG1137	ATPase activity
I6I47_04610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I47_04625	COG1660	Displays ATPase and GTPase activities
I6I47_04630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_04635	COG0540	Belongs to the ATCase OTCase family
I6I47_04640	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6I47_04650	COG2308	Evidence 4 Homologs of previously reported genes of
I6I47_04670	COG0366	Alpha amylase catalytic
I6I47_04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_04675	COG1263	PTS System
I6I47_04685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I47_04695	COG3093	addiction module antidote protein HigA
I6I47_04700	COG3711	transcriptional antiterminator
I6I47_04700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_04705	COG2706	6-phosphogluconolactonase activity
I6I47_04720	COG3964	amidohydrolase
I6I47_04750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I47_04755	COG3783	Cytochrome b(562)
I6I47_04765	COG0312	modulator of DNA gyrase
I6I47_04910	COG4695	Portal protein
I6I47_04920	COG1196	nuclear chromosome segregation
I6I47_04990	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I47_04995	COG3028	Belongs to the UPF0307 family
I6I47_05000	COG2732	(Barnase) inhibitor
I6I47_05015	COG1289	transmembrane transporter activity
I6I47_05020	COG1566	PFAM secretion protein HlyD family protein
I6I47_05030	COG0583	DNA-binding transcription factor activity
I6I47_05090	COG0312	modulator of DNA gyrase
I6I47_05095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I47_05100	COG3164	Protein of unknown function
I6I47_05110	COG0424	maF-like protein
I6I47_05115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6I47_05120	COG1792	Involved in formation and maintenance of cell shape
I6I47_05125	COG1077	Cell shape determining protein MreB Mrl
I6I47_05130	COG2199	diguanylate cyclase activity
I6I47_05130	COG2200	EAL domain
I6I47_05135	COG0604	alcohol dehydrogenase
I6I47_05145	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I47_05150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I47_05155	COG0511	ligase activity, forming carbon-carbon bonds
I6I47_05160	COG0439	Biotin carboxylase
I6I47_05165	COG3924	membrane
I6I47_05170	COG4145	pantothenate transmembrane transporter activity
I6I47_05175	COG2264	protein methyltransferase activity
I6I47_05180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I47_05185	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6I47_05195	COG3133	Outer membrane lipoprotein
I6I47_05200	COG1278	Cold shock
I6I47_05205	COG1278	Cold shock
I6I47_05210	COG0471	metal ion transport
I6I47_05215	COG1560	Kdo2-lipid A biosynthetic process
I6I47_05225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_05230	COG4597	amino acid ABC transporter
I6I47_05235	COG0765	amino acid transport
I6I47_05240	COG1126	abc transporter atp-binding protein
I6I47_05250	COG1380	Effector of murein hydrolase LrgA
I6I47_05255	COG0583	DNA-binding transcription factor activity
I6I47_05260	COG0025	NhaP-type Na H and K H
I6I47_05265	COG2252	PERMEase
I6I47_05280	COG3550	peptidyl-serine autophosphorylation
I6I47_05290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I47_05295	COG2315	Protein conserved in bacteria
I6I47_05300	COG1448	Aminotransferase
I6I47_05330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I47_05340	COG0735	belongs to the Fur family
I6I47_05345	COG3237	CsbD-like
I6I47_05350	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I47_05355	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I47_05360	COG2937	Belongs to the GPAT DAPAT family
I6I47_05365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I47_05370	COG3161	chorismate lyase activity
I6I47_05385	COG4580	involved in the transport of maltose and maltodextrins
I6I47_05400	COG2182	Extracellular solute-binding protein
I6I47_05405	COG1175	transmembrane transport
I6I47_05410	COG3833	ABC-type maltose transport systems, permease component
I6I47_05420	COG0166	Belongs to the GPI family
I6I47_05425	COG0527	aspartate kinase activity
I6I47_05450	COG1414	Transcriptional regulator
I6I47_05455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I47_05460	COG2224	Isocitrate lyase
I6I47_05465	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I47_05470	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6I47_05515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I47_05520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I47_05525	COG0009	L-threonylcarbamoyladenylate synthase
I6I47_05530	COG0551	DNA topoisomerase type I activity
I6I47_05540	COG0758	DNA mediated transformation
I6I47_05545	COG0242	peptide deformylase activity
I6I47_05550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I47_05555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I47_05555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I47_05565	COG1970	mechanosensitive ion channel activity
I6I47_05580	COG3036	rescue of stalled ribosome
I6I47_05585	COG0789	Transcriptional regulator
I6I47_05595	COG0203	ribosomal protein L17
I6I47_05600	COG0202	RNA polymerase activity
I6I47_05605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I47_05610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I47_05615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I47_05620	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I47_05625	COG0201	protein transport
I6I47_05630	COG0200	Binds to the 23S rRNA
I6I47_05635	COG1841	ribosomal large subunit assembly
I6I47_05640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I47_05645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I47_05650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I47_05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I47_05665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I47_05670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I47_05675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I47_05680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I47_05685	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I47_05690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I47_05695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I47_05700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I47_05705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I47_05710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I47_05715	COG0089	rRNA binding
I6I47_05720	COG0088	Forms part of the polypeptide exit tunnel
I6I47_05725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I47_05730	COG0051	transcription antitermination factor activity, RNA binding
I6I47_05745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I47_05755	COG0049	tRNA binding
I6I47_05760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I47_05765	COG2168	tRNA wobble position uridine thiolation
I6I47_05770	COG2923	Belongs to the DsrF TusC family
I6I47_05775	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I47_05780	COG2964	Protein conserved in bacteria
I6I47_05785	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I47_05790	COG2900	Belongs to the SlyX family
I6I47_05795	COG1047	Peptidyl-prolyl cis-trans
I6I47_05800	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6I47_05810	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I47_05815	COG0488	(ABC) transporter
I6I47_05820	COG1216	Glycosyl transferase, family 2
I6I47_05830	COG2175	clavaminate synthase activity
I6I47_05835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I47_05845	COG4521	taurine ABC transporter
I6I47_05860	COG0429	hydrolase of the alpha beta-hydrolase fold
I6I47_05865	COG3089	Belongs to the UPF0270 family
I6I47_05870	COG3954	Phosphoribulokinase
I6I47_05875	COG1765	OsmC-like protein
I6I47_05885	COG1289	transmembrane transporter activity
I6I47_05900	COG0433	COG0433 Predicted ATPase
I6I47_05905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I47_05910	COG1486	melibiose metabolic process
I6I47_05920	COG0738	Major facilitator superfamily
I6I47_05930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I47_05945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I47_05945	COG1648	precorrin-2 dehydrogenase activity
I6I47_05950	COG0180	Tryptophanyl-tRNA synthetase
I6I47_05960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I47_05980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I47_05985	COG4796	Type ii and iii secretion system protein
I6I47_06010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I47_06015	COG0494	nUDIX hydrolase
I6I47_06025	COG1011	Hydrolase
I6I47_06030	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I47_06040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I47_06055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I47_06080	COG2183	response to ionizing radiation
I6I47_06085	COG1918	ferrous iron import across plasma membrane
I6I47_06090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I47_06105	COG0596	Alpha beta hydrolase
I6I47_06115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I47_06115	COG0316	Belongs to the HesB IscA family
I6I47_06125	COG1640	4-alpha-glucanotransferase
I6I47_06130	COG0058	SHG alpha-glucan phosphorylase activity
I6I47_06135	COG2909	trisaccharide binding
I6I47_06150	COG0705	Rhomboid family
I6I47_06155	COG1349	DNA-binding transcription factor activity
I6I47_06165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I47_06170	COG0058	SHG alpha-glucan phosphorylase activity
I6I47_06175	COG0297	glycogen (starch) synthase activity
I6I47_06185	COG1523	belongs to the glycosyl hydrolase 13 family
I6I47_06190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I47_06195	COG3275	phosphorelay sensor kinase activity
I6I47_06215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I47_06220	COG2095	MarC family integral membrane protein
I6I47_06225	COG3265	gluconokinase activity
I6I47_06230	COG2610	gluconate transmembrane transporter activity
I6I47_06235	COG1609	Transcriptional regulator
I6I47_06240	COG1741	Belongs to the pirin family
I6I47_06245	COG1247	-acetyltransferase
I6I47_06250	COG1082	Xylose isomerase domain protein TIM barrel
I6I47_06255	COG0673	inositol 2-dehydrogenase activity
I6I47_06265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I47_06275	COG3718	enzyme involved in inositol metabolism
I6I47_06285	COG2814	Major facilitator Superfamily
I6I47_06290	COG0583	DNA-binding transcription factor activity
I6I47_06300	COG0561	phosphatase activity
I6I47_06310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I47_06310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I47_06315	COG0583	DNA-binding transcription factor activity
I6I47_06320	COG1648	precorrin-2 dehydrogenase activity
I6I47_06320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I47_06330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I47_06340	COG4865	methylaspartate mutase activity
I6I47_06345	COG3799	methylaspartate ammonia-lyase activity
I6I47_06360	COG1301	dicarboxylic acid transport
I6I47_06385	COG0306	phosphate transporter
I6I47_06395	COG0589	response to stress
I6I47_06410	COG0742	ribosomal rna small subunit methyltransferase
I6I47_06420	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I47_06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I47_06435	COG1295	ribonuclease BN
I6I47_06440	COG2134	cdp-diacylglycerol pyrophosphatase
I6I47_06445	COG2982	Protein involved in outer membrane biogenesis
I6I47_06450	COG2200	EAL domain
I6I47_06455	COG1942	4-Oxalocrotonate Tautomerase
I6I47_06460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I47_06465	COG0612	Peptidase, M16
I6I47_06470	COG1301	dicarboxylic acid transport
I6I47_06485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I47_06490	COG2200	EAL domain
I6I47_06490	COG2199	diguanylate cyclase activity
I6I47_06495	COG3118	belongs to the thioredoxin family
I6I47_06495	COG0457	Tetratricopeptide repeat
I6I47_06500	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6I47_06505	COG1215	transferase activity, transferring glycosyl groups
I6I47_06510	COG1215	transferase activity, transferring glycosyl groups
I6I47_06515	COG1192	Involved in chromosome partitioning
I6I47_06535	COG2194	sulfuric ester hydrolase activity
I6I47_06540	COG4608	Belongs to the ABC transporter superfamily
I6I47_06545	COG0444	Belongs to the ABC transporter superfamily
I6I47_06550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I47_06555	COG0601	transmembrane transport
I6I47_06560	COG0747	negative chemotaxis
I6I47_06570	COG1764	response to oxidative stress
I6I47_06575	COG2194	sulfuric ester hydrolase activity
I6I47_06580	COG2197	response regulator
I6I47_06585	COG3851	Histidine kinase
I6I47_06590	COG2271	Major facilitator Superfamily
I6I47_06610	COG2831	hemolysin activation secretion protein
I6I47_06615	COG3210	domain, Protein
I6I47_06625	COG3328	transposase activity
I6I47_06650	COG1609	Transcriptional regulator
I6I47_06660	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I47_06665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I47_06670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I47_06675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I47_06690	COG2723	6-phospho-beta-galactosidase activity
I6I47_06695	COG1482	cell wall glycoprotein biosynthetic process
I6I47_06730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I47_06735	COG2986	histidine ammonia-lyase
I6I47_06820	COG0582	viral genome integration into host DNA
I6I47_06830	COG1609	Transcriptional regulator
I6I47_06830	COG2207	Transcriptional regulator
I6I47_06835	COG4214	carbohydrate transport
I6I47_06845	COG4213	ABC transporter substrate-binding protein
I6I47_06850	COG2115	Belongs to the xylose isomerase family
I6I47_06855	COG1070	Carbohydrate kinase
I6I47_06860	COG3121	Chaperone
I6I47_06875	COG3274	enterobacterial common antigen metabolic process
I6I47_06885	COG3276	selenocysteine insertion sequence binding
I6I47_06890	COG1921	L-seryl-tRNASec selenium transferase activity
I6I47_06895	COG3058	Necessary for formate dehydrogenase activity
I6I47_06900	COG2864	formate dehydrogenase
I6I47_06905	COG0437	4 iron, 4 sulfur cluster binding
I6I47_06915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I47_06920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I47_06925	COG0840	transmembrane signaling receptor activity
I6I47_06930	COG2258	MOSC domain
I6I47_06950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I47_06960	COG3722	fumarate hydratase activity
I6I47_06965	COG0246	Mannitol dehydrogenase
I6I47_06970	COG2213	PTS system mannitol-specific
I6I47_06970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_06980	COG0751	glycine-tRNA ligase activity
I6I47_06985	COG0752	glycyl-tRNA synthetase alpha subunit
I6I47_06990	COG2818	Glycosylase
I6I47_06995	COG0456	acetyltransferase
I6I47_07025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I47_07030	COG0366	Alpha amylase catalytic
I6I47_07035	COG3977	Valine--pyruvate aminotransferase
I6I47_07040	COG2985	domain, Protein
I6I47_07040	COG0569	domain protein
I6I47_07055	COG5645	(Lipo)protein
I6I47_07060	COG0823	Involved in the tonB-independent uptake of proteins
I6I47_07070	COG3727	T/G mismatch-specific endonuclease activity
I6I47_07090	COG2423	ornithine cyclodeaminase activity
I6I47_07095	COG0561	phosphatase activity
I6I47_07100	COG0187	DNA topoisomerase II activity
I6I47_07105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I47_07110	COG0592	DNA-directed DNA polymerase activity
I6I47_07115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I47_07120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I47_07125	COG0594	ribonuclease P activity
I6I47_07135	COG0706	membrane insertase activity
I6I47_07140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I47_07145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I47_07155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I47_07160	COG2011	ABC-type metal ion transport system permease component
I6I47_07165	COG0840	transmembrane signaling receptor activity
I6I47_07170	COG0431	NADPH-dependent FMN reductase
I6I47_07180	COG4566	intracellular signal transduction
I6I47_07190	COG2252	PERMEase
I6I47_07195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I47_07200	COG0765	amino acid transport
I6I47_07205	COG0765	amino acid transport
I6I47_07210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_07220	COG0704	Plays a role in the regulation of phosphate uptake
I6I47_07230	COG0581	inorganic phosphate transmembrane transporter activity
I6I47_07235	COG0573	inorganic phosphate transmembrane transporter activity
I6I47_07240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I47_07250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I47_07255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I47_07260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I47_07265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I47_07270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I47_07275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I47_07280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I47_07290	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I47_07295	COG3312	ion transport
I6I47_07300	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I47_07305	COG0445	tRNA wobble uridine modification
I6I47_07310	COG0716	FMN binding
I6I47_07315	COG1522	sequence-specific DNA binding
I6I47_07320	COG2502	aspartate--ammonia ligase
I6I47_07330	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6I47_07335	COG0714	Associated with various cellular activities
I6I47_07340	COG3158	transport of potassium into the cell
I6I47_07345	COG1869	D-ribose catabolic process
I6I47_07355	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_07360	COG1879	ABC-type sugar transport system periplasmic component
I6I47_07365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I47_07370	COG1609	Transcriptional regulator
I6I47_07375	COG0477	Major facilitator Superfamily
I6I47_07380	COG2186	Transcriptional regulator
I6I47_07410	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I47_07420	COG3084	Protein conserved in bacteria
I6I47_07425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I47_07430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I47_07435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I47_07435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I47_07440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I47_07445	COG3078	GTPase activator activity
I6I47_07450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I47_07460	COG3852	Histidine kinase
I6I47_07475	COG1011	Hydrolase
I6I47_07480	COG1295	ribonuclease BN
I6I47_07485	COG1490	D-aminoacyl-tRNA deacylase activity
I6I47_07490	COG0456	acetyltransferase
I6I47_07495	COG3423	Transcriptional regulator
I6I47_07515	COG2982	Protein involved in outer membrane biogenesis
I6I47_07520	COG2233	PERMEase
I6I47_07525	COG0786	glutamate:sodium symporter activity
I6I47_07535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I47_07540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I47_07545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I47_07550	COG1758	RNA polymerase activity
I6I47_07560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I47_07565	COG2860	membrane
I6I47_07575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I47_07580	COG1024	Enoyl-CoA hydratase
I6I47_07585	COG5001	Diguanylate cyclase
I6I47_07595	COG1561	YicC-like family, N-terminal region
I6I47_07600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I47_07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I47_07610	COG1309	transcriptional regulator
I6I47_07615	COG0756	dUTP diphosphatase activity
I6I47_07620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I47_07625	COG2003	Belongs to the UPF0758 family
I6I47_07630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I47_07635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I47_07640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I47_07645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I47_07655	COG1519	Transferase
I6I47_07660	COG0859	PFAM glycosyl transferase family 9
I6I47_07665	COG0859	PFAM glycosyl transferase family 9
I6I47_07670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I47_07675	COG0156	8-amino-7-oxononanoate synthase activity
I6I47_07680	COG1063	alcohol dehydrogenase
I6I47_07695	COG2861	carbohydrate metabolic process
I6I47_07700	COG4942	peptidase
I6I47_07705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I47_07710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I47_07715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I47_07720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I47_07725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I47_07730	COG1045	serine acetyltransferase
I6I47_07735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I47_07740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I47_07740	COG2169	Transcriptional regulator
I6I47_07745	COG2205	protein histidine kinase activity
I6I47_07750	COG0745	RESPONSE REGULATOR receiver
I6I47_07755	COG3678	ATP-independent chaperone mediated protein folding
I6I47_07760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I47_07770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I47_07780	COG0149	triose-phosphate isomerase activity
I6I47_07790	COG3152	Membrane
I6I47_07810	COG2814	Major facilitator Superfamily
I6I47_07815	COG1494	fructose-1,6-bisphosphatase
I6I47_07825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I47_07830	COG3074	FtsZ-dependent cytokinesis
I6I47_07835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I47_07840	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I47_07845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I47_07850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I47_07855	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I47_07860	COG1609	Transcriptional regulator
I6I47_07865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I47_07870	COG0254	rRNA binding
I6I47_07875	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
I6I47_07880	COG0626	cystathionine gamma-synthase activity
I6I47_07885	COG0527	aspartate kinase activity
I6I47_07885	COG0460	homoserine dehydrogenase
I6I47_07895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I47_07910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I47_07915	COG0165	Argininosuccinate lyase
I6I47_07920	COG1629	transport
I6I47_07960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I47_07965	COG0678	peroxiredoxin activity
I6I47_07965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I47_07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I47_07980	COG1309	transcriptional regulator
I6I47_07990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I47_08000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I47_08040	COG1879	ABC-type sugar transport system periplasmic component
I6I47_08045	COG1129	ABC transporter
I6I47_08050	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_08055	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_08060	COG0583	DNA-binding transcription factor activity
I6I47_08065	COG3085	chromosome segregation
I6I47_08085	COG3978	acetolactate synthase activity
I6I47_08090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I47_08095	COG0129	dihydroxy-acid dehydratase activity
I6I47_08115	COG0583	DNA-binding transcription factor activity
I6I47_08120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I47_08155	COG3121	Chaperone
I6I47_08170	COG3121	Chaperone
I6I47_08180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I47_08195	COG0248	Ppx GppA phosphatase
I6I47_08205	COG3118	belongs to the thioredoxin family
I6I47_08210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I47_08215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I47_08220	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6I47_08225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I47_08230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I47_08235	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I47_08240	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I47_08245	COG0456	acetyltransferase
I6I47_08250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I47_08255	COG2244	polysaccharide biosynthetic process
I6I47_08260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I47_08300	COG3071	HemY protein
I6I47_08305	COG2959	enzyme of heme biosynthesis
I6I47_08310	COG1587	Uroporphyrinogen-III synthase
I6I47_08315	COG0181	hydroxymethylbilane synthase activity
I6I47_08320	COG3072	Adenylate cyclase
I6I47_08325	COG1965	Belongs to the frataxin family
I6I47_08335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I47_08340	COG3159	Protein conserved in bacteria
I6I47_08345	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I47_08350	COG1011	Hydrolase
I6I47_08355	COG0210	DNA helicase
I6I47_08365	COG5441	Belongs to the UPF0261 family
I6I47_08370	COG5564	TIM-barrel signal transduction protein
I6I47_08385	COG2050	protein possibly involved in aromatic compounds catabolism
I6I47_08390	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6I47_08395	COG0514	ATP-dependent DNA helicase (RecQ)
I6I47_08400	COG1280	lysine exporter protein (LysE YggA)
I6I47_08405	COG1280	lysine exporter protein (LysE YggA)
I6I47_08410	COG2267	carboxylic ester hydrolase activity
I6I47_08415	COG0561	phosphatase activity
I6I47_08420	COG0584	glycerophosphoryl diester phosphodiesterase
I6I47_08425	COG2271	Major facilitator Superfamily
I6I47_08435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I47_08440	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6I47_08445	COG0247	lactate metabolic process
I6I47_08455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I47_08460	COG0425	Belongs to the sulfur carrier protein TusA family
I6I47_08465	COG2217	Heavy metal translocating P-type atpase
I6I47_08470	COG3714	YhhN family
I6I47_08485	COG3776	membrane
I6I47_08490	COG0742	ribosomal rna small subunit methyltransferase
I6I47_08495	COG0552	protein localization to endoplasmic reticulum
I6I47_08500	COG2884	Cell division ATP-binding protein ftsE
I6I47_08505	COG2177	Part of the ABC transporter FtsEX involved in
I6I47_08535	COG0683	leucine binding
I6I47_08545	COG4177	L-phenylalanine transmembrane transporter activity
I6I47_08555	COG0410	ABC transporter
I6I47_08590	COG1653	transport
I6I47_08595	COG1175	transmembrane transport
I6I47_08600	COG0395	ABC-type sugar transport system, permease component
I6I47_08605	COG3842	ATPase activity
I6I47_08610	COG0584	glycerophosphoryl diester phosphodiesterase
I6I47_08615	COG0679	Auxin Efflux Carrier
I6I47_08620	COG0697	spore germination
I6I47_08625	COG0583	DNA-binding transcription factor activity
I6I47_08630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I47_08635	COG0412	Dienelactone hydrolase
I6I47_08650	COG1966	Carbon starvation protein
I6I47_08655	COG0586	Pfam SNARE associated Golgi protein
I6I47_08660	COG1322	Protein conserved in bacteria
I6I47_08665	COG2226	methyltransferase
I6I47_08675	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I47_08680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I47_08685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I47_08690	COG0805	protein transport
I6I47_08710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I47_08720	COG0183	Belongs to the thiolase family
I6I47_08725	COG1024	Enoyl-CoA hydratase
I6I47_08725	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I47_08730	COG0006	proline dipeptidase activity
I6I47_08735	COG1739	Uncharacterized protein family UPF0029
I6I47_08740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I47_08790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I47_08790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I47_08795	COG1072	(Pantothenic acid kinase))
I6I47_08830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I47_08840	COG0250	Participates in transcription elongation, termination and antitermination
I6I47_08845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I47_08850	COG0081	regulation of translation
I6I47_08855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I47_08860	COG0222	ribosome binding
I6I47_08865	COG0085	RNA polymerase activity
I6I47_08870	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I47_08880	COG2022	thiamine diphosphate biosynthetic process
I6I47_08885	COG2104	thiamine diphosphate biosynthetic process
I6I47_08890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I47_08905	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6I47_08910	COG2816	NAD+ diphosphatase activity
I6I47_08915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I47_08920	COG1515	deoxyribonuclease V activity
I6I47_08940	COG0151	Belongs to the GarS family
I6I47_08945	COG0138	bifunctional purine biosynthesis protein purh
I6I47_08985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I47_08990	COG3162	membrane
I6I47_08995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I47_09000	COG1301	dicarboxylic acid transport
I6I47_09005	COG2197	response regulator
I6I47_09010	COG0784	Response regulator, receiver
I6I47_09010	COG5002	protein histidine kinase activity
I6I47_09010	COG2205	protein histidine kinase activity
I6I47_09170	COG0425	Belongs to the sulfur carrier protein TusA family
I6I47_09185	COG3712	iron ion homeostasis
I6I47_09190	COG4771	TonB-dependent receptor
I6I47_09195	COG4178	(ABC) transporter
I6I47_09200	COG0612	Peptidase, M16
I6I47_09205	COG2161	toxin-antitoxin pair type II binding
I6I47_09210	COG4115	mRNA cleavage
I6I47_09215	COG1511	domain protein
I6I47_09215	COG3264	Mechanosensitive ion channel
I6I47_09220	COG4774	siderophore transport
I6I47_09230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I47_09235	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I47_09240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I47_09245	COG4558	Periplasmic binding protein
I6I47_09250	COG3720	iron ion transport
I6I47_09270	COG3721	Heme iron utilization protein
I6I47_09280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I47_09285	COG0814	amino acid
I6I47_09290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I47_09295	COG1882	Formate acetyltransferase
I6I47_09305	COG1309	transcriptional regulator
I6I47_09310	COG1929	Belongs to the glycerate kinase type-1 family
I6I47_09315	COG4232	protein-disulfide reductase activity
I6I47_09325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I47_09340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I47_09345	COG0459	protein refolding
I6I47_09360	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I47_09380	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I47_09385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6I47_09390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I47_09395	COG1053	succinate dehydrogenase
I6I47_09400	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6I47_09405	COG1511	domain protein
I6I47_09405	COG3264	Mechanosensitive ion channel
I6I47_09410	COG0688	phosphatidylethanolamine metabolic process
I6I47_09415	COG1162	GTPase activity
I6I47_09420	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I47_09440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I47_09445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I47_09445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I47_09450	COG0802	atpase or kinase
I6I47_09455	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I47_09460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I47_09465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I47_09470	COG1923	regulation of RNA biosynthetic process
I6I47_09475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I47_09480	COG0330	HflC and HflK could
I6I47_09485	COG0330	HflC and HflK could
I6I47_09490	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6I47_09495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I47_09500	COG1959	2 iron, 2 sulfur cluster binding
I6I47_09505	COG0557	exoribonuclease II activity
I6I47_09510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I47_09515	COG1960	acyl-CoA dehydrogenase activity
I6I47_09520	COG3650	response to hydrogen peroxide
I6I47_09525	COG1073	alpha beta
I6I47_09535	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I47_09540	COG2965	DNA replication, synthesis of RNA primer
I6I47_09545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I47_09550	COG0359	binds to the 23S rRNA
I6I47_09560	COG3061	Opacity-associated protein A
I6I47_09565	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I47_09575	COG0737	Belongs to the 5'-nucleotidase family
I6I47_09580	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I47_09585	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6I47_09595	COG1253	flavin adenine dinucleotide binding
I6I47_09600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I47_09615	COG2105	PFAM AIG2 family protein
I6I47_09620	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I47_09630	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I47_09635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I47_09645	COG1438	arginine binding
I6I47_09650	COG0039	L-malate dehydrogenase activity
I6I47_09655	COG3423	Transcriptional regulator
I6I47_09665	COG0142	geranyltranstransferase activity
I6I47_09670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I47_09675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I47_09680	COG0697	spore germination
I6I47_09685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I47_09690	COG0642	Histidine kinase
I6I47_09695	COG0745	RESPONSE REGULATOR receiver
I6I47_09700	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I47_09710	COG1534	Rna-binding protein
I6I47_09715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I47_09725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I47_09730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I47_09735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I47_09750	COG0779	Required for maturation of 30S ribosomal subunits
I6I47_09755	COG0195	Participates in both transcription termination and antitermination
I6I47_09760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I47_09765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I47_09770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I47_09775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I47_09780	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I47_09795	COG0513	Belongs to the DEAD box helicase family
I6I47_09805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I47_09815	COG0814	amino acid
I6I47_09820	COG3681	Belongs to the UPF0597 family
I6I47_09825	COG0826	peptidase U32
I6I47_09830	COG0826	peptidase U32
I6I47_09835	COG3154	lipid carrier protein
I6I47_09840	COG3153	acetyltransferase
I6I47_09845	COG2827	Endonuclease containing a URI domain
I6I47_09850	COG0531	amino acid
I6I47_09855	COG1982	Orn Lys Arg decarboxylase major
I6I47_09875	COG1653	transport
I6I47_09880	COG1175	transmembrane transport
I6I47_09885	COG0395	ABC-type sugar transport system, permease component
I6I47_09890	COG3842	ATPase activity
I6I47_09900	COG3787	Belongs to the UPF0306 family
I6I47_09915	COG0702	epimerase
I6I47_09920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I47_09925	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I47_09930	COG3454	Phosphonate metabolism
I6I47_09935	COG4778	phosphonate C-P lyase system protein PhnL
I6I47_09940	COG4107	phosphonate C-P lyase system protein PhnK
I6I47_09945	COG3627	carbon phosphorus lyase activity
I6I47_09950	COG3626	phosphonate metabolism
I6I47_09955	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I47_09960	COG3624	Phosphonate C-P lyase system protein PhnG
I6I47_09965	COG2188	Transcriptional regulator
I6I47_09995	COG4608	Belongs to the ABC transporter superfamily
I6I47_10000	COG0444	Belongs to the ABC transporter superfamily
I6I47_10005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I47_10010	COG0601	transmembrane transport
I6I47_10020	COG2731	YhcH YjgK YiaL family protein
I6I47_10030	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6I47_10045	COG2927	DNA polymerase III (CHI subunit)
I6I47_10050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I47_10055	COG0795	lipopolysaccharide-transporting ATPase activity
I6I47_10060	COG0795	lipopolysaccharide-transporting ATPase activity
I6I47_10070	COG0582	viral genome integration into host DNA
I6I47_10075	COG0464	growth
I6I47_10085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I47_10105	COG0454	-acetyltransferase
I6I47_10155	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I47_10160	COG1830	Aldolase
I6I47_10165	COG1879	ABC-type sugar transport system periplasmic component
I6I47_10170	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_10175	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_10180	COG1129	ABC transporter
I6I47_10185	COG2390	Transcriptional regulator
I6I47_10190	COG1070	Carbohydrate kinase
I6I47_10195	COG0859	PFAM glycosyl transferase family 9
I6I47_10210	COG2235	arginine
I6I47_10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_10220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I47_10230	COG2376	Dihydroxyacetone kinase
I6I47_10235	COG1461	Dihydroxyacetone kinase
I6I47_10240	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I47_10240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_10240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I47_10250	COG2192	nodulation
I6I47_10280	COG3284	Transcriptional regulator
I6I47_10315	COG4772	TonB-dependent receptor
I6I47_10340	COG0583	DNA-binding transcription factor activity
I6I47_10345	COG0667	Aldo Keto reductase
I6I47_10350	COG2813	Specifically methylates the guanine in position
I6I47_10355	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6I47_10360	COG0456	acetyltransferase
I6I47_10365	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I47_10370	COG2823	Periplasmic or secreted lipoprotein
I6I47_10380	COG4667	esterase of the alpha-beta hydrolase superfamily
I6I47_10385	COG0084	hydrolase, TatD family'
I6I47_10390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I47_10400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I47_10405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I47_10410	COG0813	purine-nucleoside phosphorylase activity
I6I47_10415	COG3726	membrane protein affecting hemolysin expression
I6I47_10420	COG0560	Phosphoserine phosphatase
I6I47_10435	COG0604	alcohol dehydrogenase
I6I47_10450	COG0488	(ABC) transporter
I6I47_10455	COG2885	chlorophyll binding
I6I47_10460	COG2199	diguanylate cyclase activity
I6I47_10470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I47_10475	COG0741	lytic transglycosylase activity
I6I47_10480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
I6I47_10485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6I47_10490	COG0406	alpha-ribazole phosphatase activity
I6I47_10495	COG3708	Transcriptional regulator
I6I47_10495	COG2207	Transcriptional regulator
I6I47_10500	COG3045	CreA protein
I6I47_10505	COG0745	RESPONSE REGULATOR receiver
I6I47_10520	COG0083	homoserine kinase activity
I6I47_10530	COG3022	response to hydroperoxide
I6I47_10535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I47_10540	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I47_10555	COG1584	GPR1 FUN34 yaaH family protein
I6I47_10560	COG0443	Heat shock 70 kDa protein
I6I47_10565	COG0484	heat shock protein binding
I6I47_10570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I47_10575	COG0583	DNA-binding transcription factor activity
I6I47_10580	COG0268	Binds directly to 16S ribosomal RNA
I6I47_10585	COG0196	riboflavin kinase activity
I6I47_10590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I47_10595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I47_10600	COG1047	Peptidyl-prolyl cis-trans
I6I47_10605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I47_10610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I47_10620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I47_10625	COG1280	lysine exporter protein (LysE YggA)
I6I47_10630	COG2966	Psort location CytoplasmicMembrane, score
I6I47_10635	COG3610	response to peptide
I6I47_10640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I47_10645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I47_10650	COG2967	ApaG domain
I6I47_10655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I47_10670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I47_10675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I47_10680	COG0564	pseudouridine synthase activity
I6I47_10685	COG1388	LysM domain
I6I47_10685	COG1470	cell adhesion involved in biofilm formation
I6I47_10690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I47_10695	COG0417	DNA replication proofreading
I6I47_10700	COG0586	Pfam SNARE associated Golgi protein
I6I47_10710	COG1178	ABC-type Fe3 transport system permease component
I6I47_10715	COG4143	(ABC) transporter
I6I47_10730	COG4533	DNA binding
I6I47_10735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I47_10740	COG1882	Formate acetyltransferase
I6I47_10745	COG2814	Major facilitator Superfamily
I6I47_10750	COG0814	amino acid
I6I47_10755	COG3033	Beta-eliminating lyase
I6I47_10770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I47_10775	COG0473	3-isopropylmalate dehydrogenase activity
I6I47_10780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I47_10795	COG1022	Amp-dependent synthetase and ligase
I6I47_10800	COG0028	Belongs to the TPP enzyme family
I6I47_10820	COG2001	Belongs to the MraZ family
I6I47_10825	COG0275	rRNA processing
I6I47_10830	COG3116	cell division
I6I47_10835	COG0768	penicillin binding
I6I47_10840	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I47_10845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I47_10850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I47_10860	COG0772	Belongs to the SEDS family
I6I47_10865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I47_10870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I47_10880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I47_10885	COG0849	cell division
I6I47_10890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I47_10910	COG0653	protein targeting
I6I47_10915	COG0494	nUDIX hydrolase
I6I47_10920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I47_10935	COG0516	GMP reductase activity
I6I47_10940	COG1459	type II secretion system
I6I47_10945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I47_10950	COG4969	Belongs to the N-Me-Phe pilin family
I6I47_10965	COG3725	Membrane protein required for beta-lactamase induction
I6I47_10970	COG1113	amino acid transport
I6I47_10975	COG2186	Transcriptional regulator
I6I47_10980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I47_10985	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I47_10990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I47_11000	COG4977	sequence-specific DNA binding
I6I47_11015	COG3112	Uncharacterised protein family (UPF0231)
I6I47_11030	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I47_11035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I47_11045	COG2132	Multicopper oxidase
I6I47_11050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I47_11055	COG0288	reversible hydration of carbon dioxide
I6I47_11060	COG1131	(ABC) transporter
I6I47_11065	COG0842	Transport permease protein
I6I47_11070	COG0726	polysaccharide deacetylase
I6I47_11075	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I47_11080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I47_11085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I47_11090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I47_11110	COG1489	DNA binding
I6I47_11115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I47_11120	COG1643	Atp-dependent helicase
I6I47_11125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I47_11130	COG1120	ATPase activity
I6I47_11135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I47_11140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I47_11145	COG2223	nitrite transmembrane transporter activity
I6I47_11150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I47_11160	COG0316	Belongs to the HesB IscA family
I6I47_11165	COG2860	membrane
I6I47_11175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I47_11180	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I47_11185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I47_11190	COG3850	Histidine kinase
I6I47_11190	COG4999	Histidine kinase
I6I47_11190	COG3437	response regulator, receiver
I6I47_11190	COG2205	protein histidine kinase activity
I6I47_11195	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I47_11200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I47_11205	COG3956	TIGRFAM MazG family protein
I6I47_11210	COG0504	CTP synthase activity
I6I47_11215	COG0148	phosphopyruvate hydratase activity
I6I47_11220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I47_11230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I47_11235	COG3079	Belongs to the UPF0149 family
I6I47_11240	COG0006	proline dipeptidase activity
I6I47_11245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I47_11250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I47_11255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I47_11260	COG0509	glycine decarboxylation via glycine cleavage system
I6I47_11265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I47_11265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I47_11275	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_11285	COG1272	protein, Hemolysin III
I6I47_11290	COG0354	folic acid binding
I6I47_11305	COG0745	RESPONSE REGULATOR receiver
I6I47_11310	COG2205	protein histidine kinase activity
I6I47_11315	COG4452	Inner membrane protein CreD
I6I47_11325	COG0716	FMN binding
I6I47_11330	COG4974	Belongs to the 'phage' integrase family
I6I47_11335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I47_11340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I47_11350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I47_11435	COG2944	sequence-specific DNA binding
I6I47_11440	COG3328	transposase activity
I6I47_11455	COG4319	ketosteroid isomerase
I6I47_11460	COG3706	GGDEF domain
I6I47_11470	COG1522	sequence-specific DNA binding
I6I47_11485	COG2271	Major facilitator Superfamily
I6I47_11495	COG3328	transposase activity
I6I47_11500	COG0484	heat shock protein binding
I6I47_11510	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_11515	COG1733	regulation of RNA biosynthetic process
I6I47_11520	COG0288	reversible hydration of carbon dioxide
I6I47_11540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I47_11550	COG2165	general secretion pathway protein
I6I47_11580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I47_11605	COG0840	transmembrane signaling receptor activity
I6I47_11625	COG2814	Major facilitator Superfamily
I6I47_11630	COG0583	DNA-binding transcription factor activity
I6I47_11640	COG1609	Transcriptional regulator
I6I47_11650	COG0204	Acyl-transferase
I6I47_11650	COG0318	PFAM AMP-dependent synthetase and ligase
I6I47_11655	COG0477	Major facilitator Superfamily
I6I47_11660	COG0667	Aldo Keto reductase
I6I47_11665	COG0861	Integral membrane protein TerC family
I6I47_11670	COG3066	DNA modification
I6I47_11675	COG1051	belongs to the nudix hydrolase family
I6I47_11685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I47_11690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I47_11715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6I47_11720	COG1025	Belongs to the peptidase M16 family
I6I47_11725	COG1074	ATP-dependent DNA helicase activity
I6I47_11730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I47_11740	COG1279	arginine transmembrane transporter activity
I6I47_11750	COG0583	DNA-binding transcription factor activity
I6I47_11755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I47_11760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I47_11795	COG0602	queuosine metabolic process
I6I47_11815	COG0720	synthase
I6I47_11820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I47_11825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I47_11830	COG0175	sulfate reduction
I6I47_11845	COG2234	aminopeptidase activity
I6I47_11850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I47_11850	COG1648	precorrin-2 dehydrogenase activity
I6I47_11855	COG0175	sulfate reduction
I6I47_11860	COG2895	sulfate adenylyltransferase (ATP) activity
I6I47_11865	COG0529	Catalyzes the synthesis of activated sulfate
I6I47_11875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6I47_11885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I47_11890	COG0585	pseudouridine synthase activity
I6I47_11895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I47_11900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I47_11905	COG1388	LysM domain
I6I47_11905	COG4942	peptidase
I6I47_11910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I47_11915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I47_11940	COG3188	usher protein
I6I47_11945	COG3121	Chaperone
I6I47_11955	COG3539	Fimbrial protein
I6I47_11960	COG3539	Fimbrial protein
I6I47_11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_12000	COG1538	Outer membrane efflux protein
I6I47_12020	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_12030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I47_12035	COG1858	cytochrome C peroxidase
I6I47_12045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I47_12050	COG0640	Transcriptional regulator
I6I47_12105	COG0410	ABC transporter
I6I47_12110	COG1137	ATPase activity
I6I47_12115	COG4177	L-phenylalanine transmembrane transporter activity
I6I47_12130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I47_12130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I47_12135	COG0243	molybdopterin cofactor binding
I6I47_12140	COG0437	4 iron, 4 sulfur cluster binding
I6I47_12145	COG3302	dmso reductase anchor subunit
I6I47_12150	COG3381	protein complex oligomerization
I6I47_12170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I47_12175	COG2137	regulation of response to DNA damage stimulus
I6I47_12180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I47_12185	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6I47_12210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I47_12215	COG1238	metal cluster binding
I6I47_12220	COG2918	glutathione biosynthetic process
I6I47_12225	COG1854	S-ribosylhomocysteine lyase activity
I6I47_12230	COG4536	flavin adenine dinucleotide binding
I6I47_12235	COG4137	Cytochrome C assembly protein
I6I47_12240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I47_12245	COG0228	four-way junction DNA binding
I6I47_12250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I47_12255	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I47_12260	COG0335	large ribosomal subunit rRNA binding
I6I47_12265	COG3137	Salt-induced outer membrane protein
I6I47_12270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I47_12275	COG3279	Response regulator of the LytR AlgR family
I6I47_12280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I47_12285	COG0287	Prephenate dehydrogenase
I6I47_12285	COG1605	Chorismate mutase
I6I47_12290	COG1605	Chorismate mutase
I6I47_12290	COG0077	Prephenate dehydratase
I6I47_12300	COG0542	response to heat
I6I47_12310	COG0564	pseudouridine synthase activity
I6I47_12315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I47_12325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I47_12355	COG5544	Lipoprotein
I6I47_12360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I47_12365	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I47_12365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I47_12365	COG1042	CoA-binding domain protein
I6I47_12370	COG3148	PFAM DTW domain containing protein
I6I47_12375	COG3118	belongs to the thioredoxin family
I6I47_12380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I47_12385	COG2814	Major facilitator Superfamily
I6I47_12390	COG1566	PFAM secretion protein HlyD family protein
I6I47_12395	COG1538	Outer membrane efflux protein
I6I47_12400	COG1846	Transcriptional regulator
I6I47_12410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I47_12415	COG2814	Major facilitator Superfamily
I6I47_12445	COG0765	amino acid transport
I6I47_12450	COG0765	amino acid transport
I6I47_12460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I47_12475	COG0436	Aminotransferase
I6I47_12480	COG0235	Class ii aldolase
I6I47_12485	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
I6I47_12490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I6I47_12495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6I47_12500	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I6I47_12510	COG2831	hemolysin activation secretion protein
I6I47_12520	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
I6I47_12525	COG1960	acyl-CoA dehydrogenase activity
I6I47_12535	COG0121	glutamine amidotransferase
I6I47_12540	COG3034	peptidoglycan biosynthetic process
I6I47_12545	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I47_12550	COG1805	sodium ion transport
I6I47_12555	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I47_12560	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I47_12565	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6I47_12570	COG2871	sodium ion transport
I6I47_12575	COG1477	protein flavinylation
I6I47_12580	COG2991	Protein conserved in bacteria
I6I47_12590	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I47_12595	COG2964	Protein conserved in bacteria
I6I47_12610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I47_12615	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I47_12620	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I47_12625	COG1073	alpha beta
I6I47_12635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I47_12640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I47_12645	COG2188	Transcriptional regulator
I6I47_12665	COG3459	Glycosyltransferase 36 associated
I6I47_12680	COG2226	methyltransferase
I6I47_12705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I47_12710	COG3123	guanosine phosphorylase activity
I6I47_12715	COG2974	May be involved in recombination
I6I47_12720	COG1940	carbohydrate kinase activity
I6I47_12725	COG0419	ATPase involved in DNA repair
I6I47_12730	COG0420	3'-5' exonuclease activity
I6I47_12735	COG0745	RESPONSE REGULATOR receiver
I6I47_12740	COG5002	protein histidine kinase activity
I6I47_12760	COG0366	Alpha amylase catalytic
I6I47_12780	COG0450	alkyl hydroperoxide reductase
I6I47_12785	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6I47_12790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I47_12805	COG0343	queuine tRNA-ribosyltransferase activity
I6I47_12810	COG1862	Preprotein translocase
I6I47_12815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I47_12820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I47_12830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I47_12835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I47_12835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I47_12840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I47_12845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I47_12850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I47_12855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I47_12860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I47_12865	COG0142	geranyltranstransferase activity
I6I47_12875	COG0301	tRNA thio-modification
I6I47_12875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I47_12885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I47_12890	COG1666	GTP binding
I6I47_12895	COG2814	Major facilitator Superfamily
I6I47_12900	COG0109	protoheme IX farnesyltransferase activity
I6I47_12905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I47_12910	COG1845	cytochrome c oxidase, subunit III
I6I47_12915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I47_12920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I47_12930	COG2223	nitrite transmembrane transporter activity
I6I47_12935	COG3056	Lipoprotein
I6I47_12940	COG0271	Belongs to the BolA IbaG family
I6I47_12945	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I47_12950	COG0740	serine-type endopeptidase activity
I6I47_12955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I47_12960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I47_12965	COG0776	regulation of translation
I6I47_12970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I47_12975	COG1555	photosystem II stabilization
I6I47_12980	COG0824	Thioesterase
I6I47_12985	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I47_12990	COG4533	DNA binding
I6I47_12995	COG0561	phosphatase activity
I6I47_13005	COG1522	sequence-specific DNA binding
I6I47_13010	COG1132	(ABC) transporter
I6I47_13015	COG1132	(ABC) transporter
I6I47_13020	COG0347	Belongs to the P(II) protein family
I6I47_13025	COG0004	ammonium transporteR
I6I47_13030	COG1946	Acyl-CoA thioesterase
I6I47_13035	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6I47_13040	COG3695	enzyme binding
I6I47_13070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I47_13075	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I47_13080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I47_13085	COG0254	rRNA binding
I6I47_13100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I47_13105	COG3457	Alanine racemase
I6I47_13115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I47_13120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_13125	COG1309	transcriptional regulator
I6I47_13130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6I47_13135	COG1196	nuclear chromosome segregation
I6I47_13135	COG3264	Mechanosensitive ion channel
I6I47_13150	COG2832	Protein of unknown function (DUF454)
I6I47_13155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I47_13165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I47_13170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I47_13175	COG0326	Molecular chaperone. Has ATPase activity
I6I47_13180	COG0563	adenylate kinase activity
I6I47_13185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I47_13190	COG2244	polysaccharide biosynthetic process
I6I47_13195	COG1216	Glycosyl transferase, family 2
I6I47_13195	COG1442	glycosyl transferase family 8
I6I47_13200	COG1215	transferase activity, transferring glycosyl groups
I6I47_13205	COG0438	transferase activity, transferring glycosyl groups
I6I47_13210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I47_13215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I47_13235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I47_13240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I47_13240	COG4651	solute:proton antiporter activity
I6I47_13245	COG2223	nitrite transmembrane transporter activity
I6I47_13250	COG0737	Belongs to the 5'-nucleotidase family
I6I47_13255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I47_13260	COG3735	TraB family
I6I47_13265	COG2217	Heavy metal translocating P-type atpase
I6I47_13270	COG0789	Transcriptional regulator
I6I47_13275	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6I47_13280	COG0330	HflC and HflK could
I6I47_13285	COG3118	belongs to the thioredoxin family
I6I47_13290	COG0300	oxidoreductase activity
I6I47_13295	COG2755	lipolytic protein G-D-S-L family
I6I47_13300	COG4181	ATPase activity
I6I47_13305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I47_13310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I47_13315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I47_13320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I47_13325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I47_13330	COG0215	cysteine-tRNA ligase activity
I6I47_13335	COG2501	S4 domain
I6I47_13340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I47_13350	COG0582	viral genome integration into host DNA
I6I47_13360	COG3177	Filamentation induced by cAMP protein fic
I6I47_13465	COG2850	peptidyl-arginine hydroxylation
I6I47_13470	COG2986	histidine ammonia-lyase
I6I47_13485	COG5265	(ABC) transporter
I6I47_13500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I47_13510	COG2197	response regulator
I6I47_13515	COG1278	Cold shock
I6I47_13530	COG3706	GGDEF domain
I6I47_13535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I47_13540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I47_13545	COG0321	lipoyl(octanoyl) transferase activity
I6I47_13550	COG2921	Belongs to the UPF0250 family
I6I47_13555	COG1686	Belongs to the peptidase S11 family
I6I47_13560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I47_13565	COG0772	Belongs to the SEDS family
I6I47_13570	COG0768	penicillin binding
I6I47_13580	COG0799	negative regulation of ribosome biogenesis
I6I47_13585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I47_13590	COG1466	dna polymerase III delta subunit
I6I47_13595	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
I6I47_13600	COG0495	leucyl-tRNA aminoacylation
I6I47_13605	COG2888	peptidyl-tyrosine sulfation
I6I47_13610	COG1126	abc transporter atp-binding protein
I6I47_13615	COG0765	amino acid transport
I6I47_13620	COG0765	amino acid transport
I6I47_13635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I47_13640	COG4535	Mg2 and Co2 transporter CorC
I6I47_13645	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I47_13650	COG1702	phosphate starvation-inducible protein PhoH
I6I47_13655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I47_13660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I47_13695	COG0367	asparagine synthase
I6I47_13700	COG0647	UMP catabolic process
I6I47_13705	COG1846	Transcriptional regulator
I6I47_13705	COG1940	carbohydrate kinase activity
I6I47_13710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I47_13715	COG0363	glucosamine-6-phosphate deaminase activity
I6I47_13720	COG2190	(PTS) system
I6I47_13720	COG1263	PTS System
I6I47_13720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_13725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I47_13745	COG0735	belongs to the Fur family
I6I47_13755	COG0840	transmembrane signaling receptor activity
I6I47_13765	COG0596	Alpha beta hydrolase
I6I47_13770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6I47_13775	COG0033	Phosphoglucomutase
I6I47_13790	COG0745	RESPONSE REGULATOR receiver
I6I47_13795	COG2205	protein histidine kinase activity
I6I47_13800	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I47_13805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I47_13810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I47_13830	COG2994	toxin metabolic process
I6I47_13835	COG3064	Membrane
I6I47_13835	COG1073	alpha beta
I6I47_13835	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I47_13835	COG3064	Membrane
I6I47_13835	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I47_13835	COG1073	alpha beta
I6I47_13840	COG3272	Protein of unknown function (DUF1722)
I6I47_13850	COG5212	phosphodiesterase
I6I47_13855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I47_13860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I47_13865	COG1984	allophanate hydrolase subunit 2
I6I47_13870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I47_13885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I47_13895	COG2009	succinate dehydrogenase
I6I47_13900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I47_13905	COG1053	succinate dehydrogenase
I6I47_13915	COG0567	Dehydrogenase, E1 component
I6I47_13920	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I47_13925	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I47_13930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I47_13935	COG0737	Belongs to the 5'-nucleotidase family
I6I47_13940	COG1271	oxidase subunit
I6I47_13945	COG1294	oxidase, subunit
I6I47_13950	COG4890	Cyd operon protein YbgT
I6I47_13955	COG3790	cyd operon protein YbgE
I6I47_13960	COG0824	Thioesterase
I6I47_13965	COG0811	peptide transport
I6I47_13970	COG0848	biopolymer transport protein
I6I47_13975	COG3064	Membrane
I6I47_13975	COG3064	Membrane
I6I47_13980	COG0823	Involved in the tonB-independent uptake of proteins
I6I47_13985	COG2885	chlorophyll binding
I6I47_13990	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6I47_14035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I47_14045	COG1230	cation diffusion facilitator family transporter
I6I47_14050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I47_14055	COG0588	phosphoglycerate mutase activity
I6I47_14080	COG2017	converts alpha-aldose to the beta-anomer
I6I47_14085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I47_14090	COG1085	galactose-1-phosphate uridylyltransferase
I6I47_14095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I47_14105	COG1119	ATPase activity
I6I47_14110	COG3585	molybdate ion transport
I6I47_14110	COG2005	Transcriptional regulator
I6I47_14120	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I47_14125	COG4149	molybdate abc transporter
I6I47_14135	COG0561	phosphatase activity
I6I47_14140	COG2706	6-phosphogluconolactonase activity
I6I47_14150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I47_14155	COG0156	8-amino-7-oxononanoate synthase activity
I6I47_14160	COG2226	methyltransferase
I6I47_14175	COG0556	nucleotide-excision repair
I6I47_14180	COG4628	conserved protein (DUF2132)
I6I47_14185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I47_14190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I47_14195	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I47_14200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6I47_14205	COG0314	molybdopterin synthase activity
I6I47_14210	COG0670	Belongs to the BI1 family
I6I47_14215	COG0842	Transport permease protein
I6I47_14220	COG0842	Transport permease protein
I6I47_14225	COG1131	(ABC) transporter
I6I47_14230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_14235	COG1309	transcriptional regulator
I6I47_14240	COG0513	Belongs to the DEAD box helicase family
I6I47_14245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I47_14255	COG2239	Acts as a magnesium transporter
I6I47_14265	COG1686	Belongs to the peptidase S11 family
I6I47_14270	COG0277	FAD linked oxidase domain protein
I6I47_14290	COG2261	transglycosylase associated protein
I6I47_14300	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I47_14315	COG4807	Protein conserved in bacteria
I6I47_14335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I47_14345	COG2897	thiosulfate sulfurtransferase activity
I6I47_14360	COG1732	Glycine betaine
I6I47_14365	COG1174	glycine betaine transport
I6I47_14370	COG1125	glycine betaine transport
I6I47_14375	COG1174	glycine betaine transport
I6I47_14385	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_14390	COG0583	DNA-binding transcription factor activity
I6I47_14400	COG0697	spore germination
I6I47_14420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I47_14425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I47_14445	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6I47_14455	COG1126	abc transporter atp-binding protein
I6I47_14460	COG0765	amino acid transport
I6I47_14465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_14470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6I47_14475	COG0783	Belongs to the Dps family
I6I47_14480	COG4106	trans-aconitate 2-methyltransferase activity
I6I47_14495	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I47_14510	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I47_14530	COG0488	(ABC) transporter
I6I47_14535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I47_14540	COG0303	'Molybdopterin
I6I47_14555	COG0577	efflux transmembrane transporter activity
I6I47_14555	COG1136	(ABC) transporter
I6I47_14585	COG0583	DNA-binding transcription factor activity
I6I47_14590	COG0477	Major facilitator Superfamily
I6I47_14595	COG0302	gtp cyclohydrolase
I6I47_14600	COG2311	Membrane
I6I47_14625	COG3604	Transcriptional regulator
I6I47_14630	COG3383	formate dehydrogenase (NAD+) activity
I6I47_14635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I47_14640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6I47_14650	COG3260	NADH ubiquinone oxidoreductase 20
I6I47_14655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_14660	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6I47_14660	COG3261	NADH dehydrogenase
I6I47_14665	COG0651	ATP synthesis coupled electron transport
I6I47_14670	COG4237	Hydrogenase 4 membrane
I6I47_14675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I47_14680	COG0650	Formate hydrogenlyase subunit 4
I6I47_14685	COG0651	ATP synthesis coupled electron transport
I6I47_14690	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I47_14695	COG0375	protein maturation
I6I47_14700	COG0298	carbon dioxide binding
I6I47_14705	COG2949	membrane
I6I47_14710	COG0281	malic enzyme
I6I47_14725	COG1346	cytolysis
I6I47_14730	COG1380	Effector of murein hydrolase LrgA
I6I47_14735	COG2814	Major facilitator Superfamily
I6I47_14755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I47_14755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I47_14760	COG0489	protein tyrosine kinase activity
I6I47_14765	COG0572	uridine kinase
I6I47_14775	COG2982	Protein involved in outer membrane biogenesis
I6I47_14780	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I47_14785	COG1253	flavin adenine dinucleotide binding
I6I47_14800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I47_14805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I47_14810	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6I47_14815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I47_14840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I47_14850	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I47_14855	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I47_14855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I47_14860	COG0107	imidazoleglycerol-phosphate synthase activity
I6I47_14865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I47_14875	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I47_14875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I47_14880	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I47_14890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I47_14900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I47_14910	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_14915	COG1129	ABC transporter
I6I47_14920	COG0371	Dehydrogenase
I6I47_14925	COG0531	amino acid
I6I47_14930	COG2925	Exonuclease
I6I47_14935	COG3320	Male sterility
I6I47_14935	COG1022	Amp-dependent synthetase and ligase
I6I47_14940	COG1289	transmembrane transporter activity
I6I47_14945	COG2926	Belongs to the UPF0265 family
I6I47_14955	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_14960	COG1129	ABC transporter
I6I47_14975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I47_14985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I47_15005	COG4656	Part of a membrane complex involved in electron transport
I6I47_15015	COG1012	belongs to the aldehyde dehydrogenase family
I6I47_15025	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6I47_15100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6I47_15110	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6I47_15175	COG1492	cobalamin metabolic process
I6I47_15195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I47_15260	COG3121	Chaperone
I6I47_15265	COG3188	usher protein
I6I47_15350	COG0137	argininosuccinate synthase activity
I6I47_15355	COG0534	Mate efflux family protein
I6I47_15365	COG0352	thiamine-phosphate diphosphorylase activity
I6I47_15370	COG0561	phosphatase activity
I6I47_15375	COG1349	DNA-binding transcription factor activity
I6I47_15385	COG0835	chemotaxis
I6I47_15385	COG0784	Response regulator, receiver
I6I47_15395	COG4221	oxidoreductase activity
I6I47_15415	COG3842	ATPase activity
I6I47_15425	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I47_15430	COG2271	Major facilitator Superfamily
I6I47_15445	COG4565	transcriptional regulatory protein
I6I47_15450	COG3290	protein histidine kinase activity
I6I47_15455	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6I47_15460	COG3052	prosthetic group binding
I6I47_15465	COG2301	Belongs to the HpcH HpaI aldolase family
I6I47_15470	COG3051	citrate lyase alpha subunit
I6I47_15475	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6I47_15475	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
I6I47_15485	COG0471	metal ion transport
I6I47_15500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I47_15515	COG2814	Major facilitator Superfamily
I6I47_15520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_15520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_15525	COG3122	Protein conserved in bacteria
I6I47_15545	COG3121	Chaperone
I6I47_15570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_15570	COG2205	protein histidine kinase activity
I6I47_15585	COG3228	Belongs to the MtfA family
I6I47_15595	COG1070	Carbohydrate kinase
I6I47_15600	COG1070	Carbohydrate kinase
I6I47_15625	COG3121	Chaperone
I6I47_15635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I47_15665	COG3321	synthase
I6I47_15665	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_15665	COG0604	alcohol dehydrogenase
I6I47_15670	COG3328	transposase activity
I6I47_15675	COG3250	beta-galactosidase activity
I6I47_15680	COG1609	Transcriptional regulator
I6I47_15695	COG0840	transmembrane signaling receptor activity
I6I47_15710	COG1285	pathogenesis
I6I47_15720	COG2130	NADP-dependent
I6I47_15725	COG0589	response to stress
I6I47_15745	COG1360	Flagellar Motor Protein
I6I47_15750	COG0643	Histidine kinase
I6I47_15750	COG2198	Histidine kinase
I6I47_15755	COG0835	chemotaxis
I6I47_15760	COG0840	transmembrane signaling receptor activity
I6I47_15765	COG0840	transmembrane signaling receptor activity
I6I47_15770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I47_15780	COG0745	RESPONSE REGULATOR receiver
I6I47_15785	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I47_15790	COG4935	Belongs to the peptidase S8 family
I6I47_15790	COG1404	Belongs to the peptidase S8 family
I6I47_15795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I47_15800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I47_15815	COG3418	PFAM FlgN family protein
I6I47_15820	COG2747	anti-sigma28 factor FlgM
I6I47_15830	COG1815	bacterial-type flagellum-dependent cell motility
I6I47_15835	COG1558	bacterial-type flagellum-dependent cell motility
I6I47_15840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I47_15875	COG1256	bacterial-type flagellum assembly
I6I47_15895	COG1338	Plays a role in the flagellum-specific transport system
I6I47_15915	COG1580	Controls the rotational direction of flagella during chemotaxis
I6I47_15935	COG1317	bacterial-type flagellum organization
I6I47_15950	COG1677	Flagellar hook-basal body complex protein FliE
I6I47_15955	COG0582	viral genome integration into host DNA
I6I47_15975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6I47_15980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6I47_16025	COG1191	sigma factor activity
I6I47_16035	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I47_16040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_16045	COG0765	amino acid transport
I6I47_16050	COG1126	abc transporter atp-binding protein
I6I47_16065	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I47_16065	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I47_16065	COG0506	proline dehydrogenase activity
I6I47_16080	COG3157	Type VI secretion system effector, Hcp
I6I47_16085	COG0672	)-iron permease
I6I47_16090	COG2822	iron ion transport
I6I47_16100	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I47_16110	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6I47_16120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I47_16125	COG0778	Nitroreductase
I6I47_16130	COG2267	carboxylic ester hydrolase activity
I6I47_16135	COG0251	oxidation-reduction process
I6I47_16140	COG1335	isochorismatase
I6I47_16155	COG1113	amino acid transport
I6I47_16175	COG2226	methyltransferase
I6I47_16190	COG0366	Alpha amylase catalytic
I6I47_16200	COG3136	membrane protein required for alginate biosynthesis
I6I47_16210	COG2197	response regulator
I6I47_16215	COG0322	excinuclease ABC activity
I6I47_16220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I47_16305	COG4974	Belongs to the 'phage' integrase family
I6I47_16390	COG3077	Addiction module antitoxin, RelB DinJ family
I6I47_16395	COG3041	Addiction module toxin RelE StbE family
I6I47_16520	COG3772	lysozyme
I6I47_16525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I47_16530	COG2979	Protein of unknown function (DUF533)
I6I47_16545	COG0012	GTP binding
I6I47_16555	COG0193	aminoacyl-tRNA hydrolase activity
I6I47_16565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I47_16575	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6I47_16580	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I47_16585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I47_16590	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I47_16605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I47_16610	COG0659	secondary active sulfate transmembrane transporter activity
I6I47_16615	COG3706	GGDEF domain
I6I47_16635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I47_16640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I47_16645	COG3381	protein complex oligomerization
I6I47_16655	COG0477	Major facilitator Superfamily
I6I47_16670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I47_16680	COG0673	inositol 2-dehydrogenase activity
I6I47_16685	COG0728	peptidoglycan biosynthetic process
I6I47_16690	COG0387	Pfam Sodium calcium exchanger
I6I47_16700	COG2814	Major facilitator Superfamily
I6I47_16710	COG0583	DNA-binding transcription factor activity
I6I47_16715	COG3850	Histidine kinase
I6I47_16725	COG1294	oxidase, subunit
I6I47_16730	COG1271	oxidase subunit
I6I47_16735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I47_16740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I47_16745	COG3138	arginine N-succinyltransferase
I6I47_16755	COG3724	N-succinylarginine dihydrolase activity
I6I47_16760	COG2988	succinylglutamate desuccinylase activity
I6I47_16780	COG1228	amidohydrolase
I6I47_16790	COG0402	S-adenosylhomocysteine deaminase activity
I6I47_16800	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I47_16825	COG4942	peptidase
I6I47_16835	COG2222	sugar isomerase
I6I47_16840	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_16845	COG3716	PTS system mannose fructose sorbose family IID component
I6I47_16855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_16865	COG1349	DNA-binding transcription factor activity
I6I47_16875	COG1187	pseudouridine synthase activity
I6I47_16880	COG0786	glutamate:sodium symporter activity
I6I47_16895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I47_16900	COG2226	methyltransferase
I6I47_16905	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6I47_16910	COG1801	Protein of unknown function DUF72
I6I47_16915	COG1335	isochorismatase
I6I47_16925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I47_16930	COG0494	nUDIX hydrolase
I6I47_16935	COG0217	transcriptional regulatory protein
I6I47_16940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I47_16945	COG0632	four-way junction helicase activity
I6I47_16950	COG2255	four-way junction helicase activity
I6I47_16955	COG3104	oligopeptide transport
I6I47_16960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I47_16965	COG1121	(ABC) transporter
I6I47_16970	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6I47_16975	COG0739	heme binding
I6I47_16980	COG1560	Kdo2-lipid A biosynthetic process
I6I47_16990	COG0469	pyruvate kinase activity
I6I47_16995	COG1737	Transcriptional regulator
I6I47_17000	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I47_17005	COG0800	Aldolase
I6I47_17010	COG2076	Multidrug Resistance protein
I6I47_17015	COG2076	Multidrug Resistance protein
I6I47_17020	COG0251	oxidation-reduction process
I6I47_17025	COG1199	ATP-dependent helicase activity
I6I47_17035	COG3065	identical protein binding
I6I47_17040	COG0318	PFAM AMP-dependent synthetase and ligase
I6I47_17045	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I47_17050	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I47_17055	COG2894	cell division
I6I47_17060	COG0850	regulation of cytokinetic process
I6I47_17070	COG3100	YcgL domain-containing protein
I6I47_17075	COG2951	lytic endotransglycosylase activity
I6I47_17080	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I47_17085	COG2983	Belongs to the UPF0260 family
I6I47_17110	COG0668	transmembrane transport
I6I47_17115	COG0625	glutathione transferase activity
I6I47_17140	COG2203	Gaf domain
I6I47_17140	COG4251	negative regulation of phosphorylation
I6I47_17140	COG3706	GGDEF domain
I6I47_17140	COG5001	Diguanylate cyclase
I6I47_17175	COG2814	Major facilitator Superfamily
I6I47_17185	COG3008	intermembrane lipid transfer
I6I47_17190	COG2995	paraquat-inducible protein a
I6I47_17195	COG1956	GAF domain-containing protein
I6I47_17205	COG0793	Belongs to the peptidase S41A family
I6I47_17210	COG0501	Belongs to the peptidase M48B family
I6I47_17220	COG2814	Major facilitator Superfamily
I6I47_17225	COG0823	Involved in the tonB-independent uptake of proteins
I6I47_17235	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I47_17240	COG1823	symporter activity
I6I47_17245	COG1988	membrane-bound metal-dependent
I6I47_17250	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I47_17255	COG1653	transport
I6I47_17260	COG3842	ATPase activity
I6I47_17265	COG0395	ABC-type sugar transport system, permease component
I6I47_17270	COG1175	transmembrane transport
I6I47_17280	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_17285	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6I47_17290	COG1917	Cupin 2, conserved barrel domain protein
I6I47_17295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I47_17305	COG0583	DNA-binding transcription factor activity
I6I47_17310	COG0427	acetyl-CoA hydrolase
I6I47_17315	COG1024	Enoyl-CoA hydratase
I6I47_17320	COG1703	isobutyryl-CoA mutase activity
I6I47_17325	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I47_17325	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I47_17330	COG3001	Fructosamine kinase
I6I47_17335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I47_17340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I47_17345	COG1121	(ABC) transporter
I6I47_17350	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I47_17380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I47_17385	COG0444	Belongs to the ABC transporter superfamily
I6I47_17395	COG3099	Belongs to the UPF0263 family
I6I47_17400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I47_17425	COG2350	Protein conserved in bacteria
I6I47_17430	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6I47_17435	COG1607	acyl-coa hydrolase
I6I47_17440	COG2917	probably involved in intracellular septation
I6I47_17455	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6I47_17460	COG3047	cAMP biosynthetic process
I6I47_17470	COG0159	tryptophan synthase activity
I6I47_17475	COG0133	tryptophan synthase activity
I6I47_17480	COG0134	indole-3-glycerol-phosphate synthase activity
I6I47_17480	COG0135	phosphoribosylanthranilate isomerase activity
I6I47_17490	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I47_17505	COG0613	PHP domain protein
I6I47_17510	COG0009	L-threonylcarbamoyladenylate synthase
I6I47_17515	COG1187	pseudouridine synthase activity
I6I47_17520	COG3328	transposase activity
I6I47_17530	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6I47_17535	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_17540	COG0616	signal peptide processing
I6I47_17555	COG0583	DNA-binding transcription factor activity
I6I47_17575	COG0671	phosphoesterase, PA-phosphatase related
I6I47_17580	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6I47_17585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I47_17595	COG1396	sequence-specific DNA binding
I6I47_17600	COG3135	benzoate transporter
I6I47_17610	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I47_17615	COG0023	Translation Initiation Factor
I6I47_17640	COG1349	DNA-binding transcription factor activity
I6I47_17645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I47_17650	COG2879	small protein
I6I47_17655	COG1966	Carbon starvation protein
I6I47_17660	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6I47_17665	COG0243	molybdopterin cofactor binding
I6I47_17680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I47_17690	COG4659	FMN binding
I6I47_17695	COG4658	electron transport chain
I6I47_17700	COG3708	Transcriptional regulator
I6I47_17700	COG2207	Transcriptional regulator
I6I47_17710	COG4656	Part of a membrane complex involved in electron transport
I6I47_17720	COG4657	Part of a membrane complex involved in electron transport
I6I47_17730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I47_17745	COG2274	protein secretion by the type I secretion system
I6I47_17750	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I47_17755	COG2160	L-arabinose isomerase activity
I6I47_17765	COG1879	ABC-type sugar transport system periplasmic component
I6I47_17770	COG1129	ABC transporter
I6I47_17775	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I47_17785	COG0673	inositol 2-dehydrogenase activity
I6I47_17790	COG0385	Bile acid
I6I47_17795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I47_17800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I47_17805	COG1263	PTS System
I6I47_17805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_17810	COG1609	Transcriptional regulator
I6I47_17820	COG5339	Protein conserved in bacteria
I6I47_17830	COG0114	fumarate hydratase activity
I6I47_17855	COG2814	Major facilitator Superfamily
I6I47_17860	COG0583	DNA-binding transcription factor activity
I6I47_17865	COG1940	carbohydrate kinase activity
I6I47_17870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I47_17900	COG1742	UPF0060 membrane protein
I6I47_17905	COG4221	oxidoreductase activity
I6I47_17940	COG3328	transposase activity
I6I47_17960	COG0625	glutathione transferase activity
I6I47_17985	COG1522	sequence-specific DNA binding
I6I47_17995	COG4215	(ABC) transporter
I6I47_18025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I47_18035	COG0483	inositol monophosphate 1-phosphatase activity
I6I47_18040	COG2271	Major facilitator Superfamily
I6I47_18070	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I47_18085	COG0028	Belongs to the TPP enzyme family
I6I47_18090	COG0440	acetolactate synthase activity
I6I47_18095	COG1011	Hydrolase
I6I47_18105	COG0738	Major facilitator superfamily
I6I47_18110	COG3328	transposase activity
I6I47_18115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I47_18125	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_18130	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I47_18145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I47_18150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I47_18155	COG0589	response to stress
I6I47_18160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I47_18165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6I47_18175	COG0531	amino acid
I6I47_18185	COG0745	RESPONSE REGULATOR receiver
I6I47_18190	COG2205	protein histidine kinase activity
I6I47_18195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I47_18205	COG3591	Belongs to the peptidase S1B family
I6I47_18220	COG1643	Atp-dependent helicase
I6I47_18225	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I47_18230	COG3784	Protein of unknown function (DUF1318)
I6I47_18240	COG2911	Protein conserved in bacteria
I6I47_18245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I47_18250	COG3042	response to heat
I6I47_18255	COG1285	pathogenesis
I6I47_18265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I47_18265	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I47_18265	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I47_18265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I47_18270	COG0823	Involved in the tonB-independent uptake of proteins
I6I47_18275	COG0037	tRNA processing
I6I47_18280	COG0598	Magnesium transport protein CorA
I6I47_18285	COG4166	transmembrane transport
I6I47_18290	COG2866	Carboxypeptidase
I6I47_18295	COG4948	Mandelate Racemase Muconate Lactonizing
I6I47_18300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I47_18310	COG5642	Protein of unknown function (DUF2384)
I6I47_18315	COG5654	RES domain protein
I6I47_18320	COG3768	UPF0283 membrane protein
I6I47_18325	COG3106	COG3106 Predicted ATPase
I6I47_18335	COG1983	PspC domain protein
I6I47_18345	COG1842	Phage shock protein A
I6I47_18350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I47_18365	COG4166	transmembrane transport
I6I47_18370	COG4168	peptide transport system, permease
I6I47_18375	COG4171	peptide transport system, permease
I6I47_18385	COG4172	Belongs to the ABC transporter superfamily
I6I47_18390	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I47_18390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I47_18400	COG3104	oligopeptide transport
I6I47_18420	COG0625	glutathione transferase activity
I6I47_18430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I47_18435	COG0259	pyridoxamine-phosphate oxidase activity
I6I47_18440	COG3895	Periplasmic Protein
I6I47_18445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I47_18450	COG3133	Outer membrane lipoprotein
I6I47_18455	COG1846	Transcriptional regulator
I6I47_18465	COG1566	PFAM secretion protein HlyD family protein
I6I47_18470	COG1289	transmembrane transporter activity
I6I47_18475	COG4989	oxidoreductase activity
I6I47_18480	COG3313	Fe-S protein
I6I47_18485	COG2194	sulfuric ester hydrolase activity
I6I47_18490	COG1309	transcriptional regulator
I6I47_18495	COG1902	pentaerythritol trinitrate reductase activity
I6I47_18500	COG0346	lactoylglutathione lyase activity
I6I47_18510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I47_18515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I47_18520	COG0791	NLP P60 protein
I6I47_18535	COG1609	Transcriptional regulator
I6I47_18540	COG0583	DNA-binding transcription factor activity
I6I47_18545	COG2814	Major facilitator Superfamily
I6I47_18550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I47_18555	COG0307	riboflavin synthase, alpha
I6I47_18560	COG0534	Mate efflux family protein
I6I47_18590	COG1388	LysM domain
I6I47_18590	COG1376	ErfK ybiS ycfS ynhG family protein
I6I47_18595	COG2166	iron-sulfur cluster assembly
I6I47_18605	COG0719	Fe-S assembly protein
I6I47_18610	COG0396	ATPase activity
I6I47_18615	COG0719	Fe-S assembly protein
I6I47_18620	COG0316	Belongs to the HesB IscA family
I6I47_18625	COG2050	protein possibly involved in aromatic compounds catabolism
I6I47_18635	COG0247	lactate metabolic process
I6I47_18635	COG0277	FAD linked oxidase domain protein
I6I47_18640	COG0628	permease
I6I47_18650	COG0574	Belongs to the PEP-utilizing enzyme family
I6I47_18650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I47_18655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I47_18675	COG3720	iron ion transport
I6I47_18680	COG4558	Periplasmic binding protein
I6I47_18690	COG0095	Lipoate-protein ligase
I6I47_18695	COG0791	NLP P60 protein
I6I47_18700	COG2076	Multidrug Resistance protein
I6I47_18705	COG2076	Multidrug Resistance protein
I6I47_18710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I47_18715	COG0726	polysaccharide deacetylase
I6I47_18720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I47_18720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I47_18725	COG0463	Glycosyl transferase, family 2
I6I47_18730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I47_18735	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6I47_18740	COG0386	Belongs to the glutathione peroxidase family
I6I47_18745	COG4139	cobalamin transport
I6I47_18755	COG2314	TM2 domain
I6I47_18760	COG0776	regulation of translation
I6I47_18770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I47_18780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I47_18785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I47_18790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I47_18795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I47_18800	COG4249	Peptidase C14 caspase catalytic subunit p20
I6I47_18805	COG1811	Na channel or pump
I6I47_18840	COG2095	MarC family integral membrane protein
I6I47_18845	COG1454	alcohol dehydrogenase
I6I47_18845	COG1012	belongs to the aldehyde dehydrogenase family
I6I47_18855	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6I47_18865	COG0745	RESPONSE REGULATOR receiver
I6I47_18870	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I47_18880	COG3012	SEC-C Motif Domain Protein
I6I47_18885	COG0788	formyltetrahydrofolate deformylase activity
I6I47_18905	COG0583	DNA-binding transcription factor activity
I6I47_18910	COG0708	Exodeoxyribonuclease III
I6I47_18915	COG0494	nUDIX hydrolase
I6I47_18925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I47_18935	COG0778	Nitroreductase
I6I47_18940	COG0616	signal peptide processing
I6I47_18945	COG0252	asparaginase activity
I6I47_18950	COG1335	isochorismatase
I6I47_18955	COG3139	Protein of unknown function (DUF1315)
I6I47_18960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I47_18975	COG3713	MltA-interacting MipA family protein
I6I47_18980	COG2766	serine protein kinase
I6I47_18985	COG2718	Belongs to the UPF0229 family
I6I47_19000	COG0583	DNA-binding transcription factor activity
I6I47_19010	COG2199	diguanylate cyclase activity
I6I47_19010	COG2202	Pas domain
I6I47_19010	COG2200	EAL domain
I6I47_19015	COG2814	Major facilitator Superfamily
I6I47_19020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I47_19025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I47_19030	COG2719	SpoVR family
I6I47_19035	COG2186	Transcriptional regulator
I6I47_19040	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I47_19045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I47_19060	COG3142	Participates in the control of copper homeostasis
I6I47_19065	COG3102	Protein conserved in bacteria
I6I47_19070	COG0018	arginyl-trna synthetase
I6I47_19080	COG1702	phosphate starvation-inducible protein PhoH
I6I47_19090	COG3658	cytochrome
I6I47_19095	COG1215	transferase activity, transferring glycosyl groups
I6I47_19100	COG0726	polysaccharide deacetylase
I6I47_19100	COG1649	PFAM Uncharacterised BCR, COG1649
I6I47_19105	COG0457	Tetratricopeptide repeat
I6I47_19110	COG0006	proline dipeptidase activity
I6I47_19115	COG4114	ferric iron reductase
I6I47_19120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I47_19145	COG1136	(ABC) transporter
I6I47_19145	COG0577	efflux transmembrane transporter activity
I6I47_19155	COG1136	(ABC) transporter
I6I47_19155	COG0577	efflux transmembrane transporter activity
I6I47_19170	COG0672	)-iron permease
I6I47_19185	COG2066	Belongs to the glutaminase family
I6I47_19190	COG3622	Belongs to the hyi family
I6I47_19195	COG0235	Class ii aldolase
I6I47_19200	COG3395	kinase activity
I6I47_19205	COG1349	DNA-binding transcription factor activity
I6I47_19210	COG3290	protein histidine kinase activity
I6I47_19215	COG4565	transcriptional regulatory protein
I6I47_19220	COG3493	citrate carrier protein
I6I47_19240	COG2223	nitrite transmembrane transporter activity
I6I47_19245	COG0561	phosphatase activity
I6I47_19255	COG3328	transposase activity
I6I47_19265	COG0500	methyltransferase
I6I47_19270	COG3328	transposase activity
I6I47_19315	COG4974	Belongs to the 'phage' integrase family
I6I47_19325	COG1276	copper resistance
I6I47_19330	COG2372	response to copper ion
I6I47_19335	COG1528	Iron-storage protein
I6I47_19350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I47_19355	COG1770	oligopeptidase
I6I47_19365	COG3097	Belongs to the UPF0267 family
I6I47_19370	COG3141	response to X-ray
I6I47_19375	COG0513	Belongs to the DEAD box helicase family
I6I47_19380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I47_19385	COG3140	Belongs to the UPF0181 family
I6I47_19395	COG0494	nUDIX hydrolase
I6I47_19400	COG1760	l-serine dehydratase
I6I47_19415	COG1253	flavin adenine dinucleotide binding
I6I47_19420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_19420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I47_19425	COG3715	PTS system
I6I47_19430	COG3716	PTS system mannose fructose sorbose family IID component
I6I47_19435	COG4811	Protein of unknown function (DUF986)
I6I47_19440	COG1971	Probably functions as a manganese efflux pump
I6I47_19450	COG3447	MASE1 domain protein
I6I47_19450	COG5001	Diguanylate cyclase
I6I47_19450	COG5002	protein histidine kinase activity
I6I47_19460	COG2226	methyltransferase
I6I47_19465	COG0768	penicillin binding
I6I47_19470	COG1496	oxidoreductase activity
I6I47_19490	COG1113	amino acid transport
I6I47_19525	COG2207	Transcriptional regulator
I6I47_19545	COG1132	(ABC) transporter
I6I47_19590	COG3755	Protein conserved in bacteria
I6I47_19625	COG1733	regulation of RNA biosynthetic process
I6I47_19630	COG0702	epimerase
I6I47_19635	COG2873	o-acetylhomoserine
I6I47_19655	COG0840	transmembrane signaling receptor activity
I6I47_19695	COG0538	isocitrate dehydrogenase activity
I6I47_19725	COG0538	isocitrate dehydrogenase activity
I6I47_19730	COG1187	pseudouridine synthase activity
I6I47_19740	COG0482	sulfurtransferase activity
I6I47_19745	COG2915	High frequency lysogenization protein hflD homolog
I6I47_19750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I47_19760	COG0745	RESPONSE REGULATOR receiver
I6I47_19770	COG2850	peptidyl-arginine hydroxylation
I6I47_19785	COG1940	carbohydrate kinase activity
I6I47_19790	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I47_19800	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I47_19805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I47_19810	COG3134	Outer membrane lipoprotein
I6I47_19815	COG1252	NADH dehydrogenase
I6I47_19820	COG3150	esterase
I6I47_19825	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I47_19835	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6I47_19840	COG5633	Lipoprotein
I6I47_19845	COG0537	adenosine 5'-monophosphoramidase activity
I6I47_19850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I47_19865	COG0641	radical SAM
I6I47_19885	COG1263	PTS System
I6I47_19885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I47_19890	COG0084	hydrolase, TatD family'
I6I47_19895	COG0470	DNA polymerase III
I6I47_19900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I47_19905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I47_19910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I47_19915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I47_19925	COG1028	Short-chain dehydrogenase reductase Sdr
I6I47_19930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I47_19935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I47_19940	COG0416	fatty acid biosynthetic process
I6I47_19945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I47_19950	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I47_19955	COG0424	maF-like protein
I6I47_19960	COG0564	pseudouridine synthase activity
I6I47_19965	COG1530	ribonuclease E activity
I6I47_19970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I47_19975	COG0418	dihydroorotase activity
I6I47_20005	COG0628	permease
I6I47_20010	COG1054	Belongs to the UPF0176 family
I6I47_20045	COG1560	Kdo2-lipid A biosynthetic process
I6I47_20055	COG2259	Doxx family
I6I47_20070	COG2943	transferase activity, transferring hexosyl groups
I6I47_20075	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
I6I47_20080	COG3328	transposase activity
I6I47_20100	COG3263	regulation of cellular component size
I6I47_20110	COG3916	Acyl-homoserine-lactone synthase
I6I47_20115	COG2771	luxR family
I6I47_20120	COG4235	cytochrome complex assembly
I6I47_20125	COG3088	subunit of a heme lyase
I6I47_20130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I47_20135	COG1138	Cytochrome C-type biogenesis protein
I6I47_20140	COG3301	Polysulphide reductase, NrfD
I6I47_20145	COG0437	4 iron, 4 sulfur cluster binding
I6I47_20150	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6I47_20165	COG2920	part of a sulfur-relay system
I6I47_20170	COG1254	Belongs to the acylphosphatase family
I6I47_20185	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I47_20190	COG3785	DNA binding
I6I47_20195	COG1832	CoA-binding protein
I6I47_20205	COG1803	Methylglyoxal synthase
I6I47_20210	COG0210	DNA helicase
I6I47_20215	COG3304	Inner membrane component domain
I6I47_20220	COG1289	transmembrane transporter activity
I6I47_20225	COG3070	regulator of competence-specific genes
I6I47_20230	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
I6I47_20240	COG3120	sequence-specific DNA binding
I6I47_20245	COG1067	ATP-dependent peptidase activity
I6I47_20250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I47_20260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I47_20265	COG3130	regulation of translation
I6I47_20270	COG3009	Protein conserved in bacteria
I6I47_20275	COG3008	intermembrane lipid transfer
I6I47_20275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I47_20280	COG2995	paraquat-inducible protein a
I6I47_20285	COG0488	(ABC) transporter
I6I47_20290	COG0116	Belongs to the methyltransferase superfamily
I6I47_20290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I47_20295	COG3217	Mosc domain protein beta barrel domain protein
I6I47_20295	COG0633	Ferredoxin
I6I47_20305	COG0167	dihydroorotate dehydrogenase activity
I6I47_20310	COG0308	aminopeptidase N
I6I47_20315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I47_20320	COG0017	Asparaginyl-tRNA synthetase
I6I47_20330	COG1448	Aminotransferase
I6I47_20335	COG2200	EAL domain
I6I47_20340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I47_20345	COG3108	Peptidase M15
I6I47_20350	COG2989	Protein conserved in bacteria
I6I47_20355	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I47_20365	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
I6I47_20370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I47_20375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I47_20380	COG3173	Aminoglycoside phosphotransferase
I6I47_20385	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I47_20390	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I47_20395	COG1278	Cold shock
I6I47_20405	COG5383	Protein conserved in bacteria
I6I47_20410	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I47_20420	COG2333	competence protein COMEC
I6I47_20420	COG0658	competence protein
I6I47_20425	COG0776	regulation of translation
I6I47_20430	COG0539	negative regulation of cytoplasmic translation
I6I47_20435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I47_20440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I47_20445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I47_20450	COG2323	membrane
I6I47_20455	COG0252	asparaginase activity
I6I47_20460	COG1944	ATP diphosphatase activity
I6I47_20470	COG2116	formate transmembrane transporter activity
I6I47_20475	COG1882	Formate acetyltransferase
I6I47_20480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I47_20485	COG2814	Major facilitator Superfamily
I6I47_20490	COG3328	transposase activity
I6I47_20500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I47_20505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I47_20510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I47_20515	COG3107	peptidoglycan biosynthetic process
I6I47_20515	COG1674	ftsk spoiiie
I6I47_20520	COG1522	sequence-specific DNA binding
I6I47_20525	COG0492	ferredoxin-NADP+ reductase activity
I6I47_20535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I47_20540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I47_20545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I47_20550	COG0542	response to heat
I6I47_20555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I47_20560	COG1278	Cold shock
I6I47_20570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I47_20575	COG2990	Protein conserved in bacteria
I6I47_20580	COG3593	DNA synthesis involved in DNA repair
I6I47_20585	COG2431	L-lysine efflux transmembrane transporter activity
I6I47_20590	COG1151	hydroxylamine reductase activity
I6I47_20595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I47_20600	COG0028	Belongs to the TPP enzyme family
I6I47_20610	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I47_20615	COG0702	epimerase
I6I47_20620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I47_20630	COG1126	abc transporter atp-binding protein
I6I47_20635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_20640	COG4215	(ABC) transporter
I6I47_20645	COG4160	amino acid transport
I6I47_20650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I47_20655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I47_20665	COG1177	transmembrane transport
I6I47_20670	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I47_20675	COG3842	ATPase activity
I6I47_20680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I47_20700	COG2985	domain, Protein
I6I47_20700	COG0569	domain protein
I6I47_20710	COG0671	phosphoesterase, PA-phosphatase related
I6I47_20715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I47_20720	COG1349	DNA-binding transcription factor activity
I6I47_20725	COG0814	amino acid
I6I47_20730	COG1760	l-serine dehydratase
I6I47_20740	COG1686	Belongs to the peptidase S11 family