locus-tag class description LI89_00005 ENOG4105QTB Flavodoxin LI89_00010 ENOG4108VVK transcriptional Regulator, AsnC LI89_00015 ENOG4105CU9 asparagine synthetase A LI89_00025 ENOG4105EV2 VWA domain protein interacting with AAA ATPase LI89_00030 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) LI89_00040 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) LI89_00050 ENOG4105CNN ABC, transporter LI89_00055 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator LI89_00060 ENOG4108RVA ribokinase LI89_00065 ENOG4105ETE Transcriptional regulator (LacI family LI89_00070 ENOG4105C0R drug resistance transporter emrb qaca subfamily LI89_00075 ENOG4107EJG GntR family transcriptional regulator LI89_00100 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b LI89_00110 ENOG4105PC1 Conserved Protein LI89_00115 ENOG4105E27 serine threonine protein kinase LI89_00120 ENOG4108Z33 Thiol disulfide Interchange Protein LI89_00125 ENOG4105C2M dna polymerase I LI89_00130 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) LI89_00135 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) LI89_00140 ENOG4105D4P Coproporphyrinogen iii oxidase LI89_00145 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LI89_00150 ENOG4105CUX Signal transduction histidine kinase LI89_00155 ENOG4105C5F glutamine synthetase LI89_00165 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 LI89_00170 ENOG4107S2Z UPF0761 membrane protein LI89_00175 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) LI89_00180 ENOG4105SUU thioesterase domain LI89_00185 ENOG4105HVQ Regulatory factor of maltose metabolism LI89_00205 ENOG4105JV1 AsmA family LI89_00210 ENOG4105C2W permease LI89_00215 ENOG4105D6U Sodium Glutamate Symporter LI89_00220 ENOG4105CB5 ATP-dependent DNA helicase recG LI89_00225 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase LI89_00230 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LI89_00235 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) LI89_00245 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) LI89_00250 ENOG4105EN6 Membrane LI89_00260 ENOG4105D9N nucleoside LI89_00265 ENOG4105E39 Enoyl-CoA hydratase LI89_00270 ENOG4105BZU Histidine kinase LI89_00285 ENOG4105DSJ YicC domain protein LI89_00290 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) LI89_00295 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LI89_00300 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) LI89_00305 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) LI89_00310 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase LI89_00315 ENOG4105W5Q DNA repair protein (RadC LI89_00320 ENOG4105KDC 50s ribosomal protein l28 LI89_00325 ENOG4105W0E 50S ribosomal protein L33 LI89_00330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) LI89_00335 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) LI89_00345 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase LI89_00350 ENOG4105D16 lipopolysaccharide heptosyltransferase i LI89_00355 ENOG4105XA0 heptosyltransferase ii LI89_00360 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) LI89_00365 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) LI89_00370 ENOG4105CPQ Dehydrogenase LI89_00375 ENOG4105PXI polysaccharide deacetylase LI89_00380 ENOG41063SB peptidase LI89_00385 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LI89_00390 ENOG4107YZP Rhodanese domain protein LI89_00395 ENOG4105VW4 glutaredoxin 3 LI89_00400 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) LI89_00405 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase LI89_00410 ENOG4105D7W serine acetyltransferase LI89_00415 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) LI89_00420 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LI89_00425 ENOG4105E0F Histidine kinase LI89_00430 ENOG4105E3W Two component transcriptional regulator (Winged helix family LI89_00435 ENOG4105FMW periplasmic LI89_00440 ENOG41076HS cation diffusion facilitator family transporter LI89_00450 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein LI89_00460 ENOG4105CP7 Triose-phosphate isomerase LI89_00465 ENOG4105EBK exported protein LI89_00470 ENOG4108VTS Membrane LI89_00475 ENOG4105DP0 ferredoxin-NADP reductase LI89_00480 ENOG4105E5M Multidrug resistance protein D LI89_00485 ENOG4105CBT Fructose-1,6-bisphosphatase LI89_00490 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) LI89_00495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LI89_00505 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) LI89_00510 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) LI89_00515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase LI89_00520 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) LI89_00525 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) LI89_00530 ENOG41063M6 Cell Division Protein LI89_00535 ENOG4105ETE Transcriptional regulator (LacI family LI89_00540 ENOG4105C25 Primosomal protein n' LI89_00545 ENOG4105VFB Binds the 23S rRNA (By similarity) LI89_00550 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) LI89_00555 ENOG4105C28 cystathionine LI89_00560 ENOG4105CFH Aspartokinase LI89_00565 ENOG4105SYT Methylenetetrahydrofolate reductase LI89_00570 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) LI89_00580 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase LI89_00585 ENOG4105CAS nag kinase LI89_00590 ENOG4105CH7 arginosuccinase LI89_00595 ENOG4105X58 receptor LI89_00625 ENOG4107QZV Type I secretion membrane fusion protein LI89_00635 ENOG4107QN2 dihydrolipoyl dehydrogenase LI89_00640 ENOG4105EHV domain protein LI89_00645 ENOG4105C5Q Transcriptional regulator LI89_00650 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) LI89_00655 ENOG4105EJ2 Transcriptional regulator LI89_00660 ENOG4108Y73 Membrane LI89_00665 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) LI89_00675 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) LI89_00705 ENOG4105T42 (LipO)protein LI89_00710 ENOG4105JIM Phosphatidylserine synthase LI89_00730 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) LI89_00770 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator LI89_00775 ENOG4105C2J ABC transporter LI89_00780 ENOG4107R9N ABC transporter LI89_00785 ENOG41062B0 ABC transporter, permease LI89_00790 ENOG4105CVI Transcriptional regulator LI89_00795 ENOG4108WFC UPF0438 protein yifE LI89_00800 ENOG4105C0P Mg chelatase subunit ChlI LI89_00810 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit LI89_00815 ENOG4105CM2 brancheD-chain amino acid aminotransferase LI89_00820 ENOG4105C01 Dihydroxy-acid dehydratase LI89_00825 ENOG4105C7B Threonine dehydratase LI89_00835 ENOG4105EMY transcriptional regulator LI89_00840 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase LI89_00860 ENOG41060S4 immunity protein LI89_00865 ENOG4108VEV chaperone LI89_00875 ENOG4105CW0 outer membrane usher protein LI89_00880 ENOG4105GQR Chaperone LI89_00890 ENOG4105KQ5 peptidylprolyl cis-trans isomerase LI89_00895 ENOG4105C4R Atp-dependent dna helicase LI89_00905 ENOG4105C9X ppx gppa phosphatase LI89_00915 ENOG4105K63 Thioredoxin LI89_00925 ENOG4105ESV Glycosyl transferase, family 4 LI89_00930 ENOG4105SFE lipopolysaccharide biosynthesis protein LI89_00935 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase LI89_00940 ENOG4108IJ1 Dehydrogenase LI89_00945 ENOG4105C1B dTDP-glucose 4-6-dehydratase LI89_00950 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) LI89_00955 ENOG4108WJ1 acetyltransferase LI89_00960 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase LI89_00965 ENOG4105EGZ biosynthesis protein LI89_00970 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) LI89_00985 ENOG4105C85 amino acid LI89_01015 ENOG410601J HemY protein LI89_01020 ENOG4105ECF c-methyltransferase LI89_01025 ENOG41076E6 Uroporphyrinogen-III Synthase LI89_01030 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) LI89_01045 ENOG4105XQ6 frataxin-like protein LI89_01050 ENOG4105S7Z (LipO)protein LI89_01055 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) LI89_01060 ENOG4105CT0 Protein of unknown function, DUF484 LI89_01065 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LI89_01070 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant LI89_01075 ENOG4105C4R Atp-dependent dna helicase LI89_01085 ENOG4105EQN UPF0261 protein LI89_01095 ENOG4107QUT magnesium and cobalt transport protein CorA LI89_01100 ENOG4105FR1 rard protein LI89_01105 ENOG4108VUY thioesterase Superfamily protein LI89_01110 ENOG4105HDD phospholipase LI89_01115 ENOG4105C9U ATP-dependent DNA helicase RecQ LI89_01130 ENOG4108EUD Lysophospholipase LI89_01135 ENOG4105DQF Hydrolase LI89_01140 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase LI89_01145 ENOG4105CXY transporter LI89_01155 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A LI89_01160 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B LI89_01165 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) LI89_01170 ENOG4108W1V Lipoprotein LI89_01175 ENOG4105EX9 Membrane LI89_01180 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) LI89_01185 ENOG4105C59 p-type ATPase LI89_01190 ENOG4107FS9 Membrane LI89_01205 ENOG4105MG3 Membrane LI89_01210 ENOG4106H78 methyltransferase LI89_01215 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LI89_01220 ENOG4105CAK Cell division ATP-binding protein ftsE LI89_01225 ENOG4105CRP Part of the ABC transporter FtsEX involved in LI89_01235 ENOG4105U59 -acetyltransferase LI89_01240 ENOG4105CP9 extracellular ligand-binding receptor LI89_01245 ENOG4105C32 Amino acid ABC transporter (Permease) LI89_01250 ENOG4105CF8 branched-chain amino acid ABC transporter, permease LI89_01255 ENOG4105C0Z ABC transporter LI89_01260 ENOG4108IV0 ABC, transporter LI89_01295 ENOG4105BZ7 extracellular solute-binding protein family 1 LI89_01300 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component LI89_01305 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component LI89_01310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LI89_01315 ENOG4107T6V glycerophosphoryl diester phosphodiesterase LI89_01320 ENOG4105RK9 auxin efflux carrier LI89_01330 ENOG4105DZ2 Transcriptional regulator LI89_01335 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) LI89_01340 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) LI89_01345 ENOG4108I5U Uridine phosphorylase LI89_01360 ENOG4108KF1 Membrane LI89_01365 ENOG4105CGY Dna recombination protein LI89_01370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LI89_01375 ENOG4105JC1 sterol-binding domain protein LI89_01380 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) LI89_01385 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) LI89_01390 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) LI89_01395 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) LI89_01405 ENOG4105D52 delta-aminolevulinic acid dehydratase LI89_01410 ENOG4105MDZ Transcriptional activator rfaH LI89_01415 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) LI89_01420 ENOG4107QK7 reductase LI89_01425 ENOG4105CHU acetyl-coa acetyltransferase LI89_01430 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase LI89_01435 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) LI89_01440 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein LI89_01445 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) LI89_01450 ENOG4108RR8 protoporphyrinogen oxidase LI89_01480 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase LI89_01485 ENOG4105CS9 pantothenic acid kinase LI89_01515 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LI89_01520 ENOG4105PM1 preprotein translocase subunit SecE LI89_01525 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) LI89_01530 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) LI89_01535 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) LI89_01540 ENOG4108VZM 50s ribosomal protein L10 LI89_01545 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) LI89_01550 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LI89_01555 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LI89_01560 ENOG4105D41 biosynthesis protein thiH LI89_01565 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) LI89_01570 ENOG4105WHD thiamine biosynthesis protein ThiS LI89_01575 ENOG4105D06 uba thif-type nad fad binding protein LI89_01585 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) LI89_01590 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor LI89_01595 ENOG4105E09 nadh pyrophosphatase LI89_01605 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) LI89_01610 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) LI89_01615 ENOG4105R2J Conserved Protein LI89_01625 ENOG4108T8B Protein of unknown function (DUF1481) LI89_01630 ENOG4105C12 Phosphoribosylglycinamide synthetase LI89_01635 ENOG4105DC1 bifunctional purine biosynthesis protein purh LI89_01680 ENOG4107QN1 sodium solute LI89_01685 ENOG41062QD Membrane LI89_01690 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) LI89_01695 ENOG4105CK2 sodium dicarboxylate symporter LI89_01700 ENOG4105WH1 Two component transcriptional regulator luxr family LI89_01705 ENOG4105BZU Histidine kinase LI89_01735 ENOG4105ZQI secreted protein LI89_01745 ENOG4108SZ7 secretion system effector LI89_01805 ENOG4105UQF type iii secretion LI89_01810 ENOG4106H1D secretion system apparatus protein LI89_01820 ENOG4108JIR Flagellum-specific ATP synthase LI89_01835 ENOG41063Q7 Type III secretion system protein LI89_01840 ENOG4108HHI Type III secretion system protein LI89_01845 ENOG41083GP type iii secretion LI89_01850 ENOG4108TN6 type iii secretion LI89_01855 ENOG4108IUF type iii secretion LI89_01860 ENOG41066VF YeeE YedE family protein LI89_01865 ENOG4105KSU Redox protein LI89_01885 ENOG4108S3W Anti-feci sigma factor, fecr LI89_01890 ENOG4105PE1 Receptor LI89_01895 ENOG4105CQ0 ABC transporter LI89_01900 ENOG4107RAN Peptidase, M16 LI89_01905 ENOG4105EGS Mechanosensitive ion channel LI89_01910 ENOG4105E0K tonB-dependent siderophore receptor LI89_01920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LI89_01925 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) LI89_01930 ENOG4105EHG Permease protein LI89_01935 ENOG4107R4I Periplasmic binding protein LI89_01940 ENOG4106QJH hemin transport protein LI89_01945 ENOG4107ENK receptor LI89_01950 ENOG4107F3C Hemin uptake protein LI89_01960 ENOG41090JE Utilization Protein LI89_01965 ENOG4105D4P Coproporphyrinogen iii oxidase LI89_01970 ENOG4105C7B Threonine dehydratase LI89_01975 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) LI89_01980 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LI89_01985 ENOG4105C6N Formate acetyltransferase LI89_01995 ENOG4108SIC Transcriptional regulator LI89_02000 ENOG4105BZW Glycerate kinase LI89_02005 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) LI89_02015 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter LI89_02030 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) LI89_02045 ENOG4108ZVF (LipO)protein LI89_02050 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein LI89_02055 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LI89_02065 ENOG4105KPY Small multidrug resistance protein LI89_02075 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) LI89_02080 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) LI89_02095 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) LI89_02100 ENOG4105EGS Mechanosensitive ion channel LI89_02105 ENOG4105DJ4 phosphatidylserine decarboxylase LI89_02110 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) LI89_02115 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) LI89_02135 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) LI89_02140 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) LI89_02145 ENOG4105K8N protein family UPF0079, ATPase LI89_02150 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LI89_02155 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LI89_02160 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) LI89_02165 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) LI89_02170 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) LI89_02175 ENOG4107QJR hflk protein LI89_02180 ENOG4105EPW hflc protein LI89_02190 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis LI89_02195 ENOG4105KPV Transcriptional regulator LI89_02200 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) LI89_02205 ENOG4105C2N RNA methyltransferase TrmH family group 3 LI89_02210 ENOG4105CSU acyl-Coa dehydrogenase LI89_02215 ENOG4105WSB biofilm stress and motility protein A LI89_02220 ENOG4108MXZ Esterase LI89_02230 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) LI89_02235 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) LI89_02240 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) LI89_02245 ENOG4105K9Q Binds to the 23S rRNA (By similarity) LI89_02255 ENOG4105FHY Opacity-associated protein A LI89_02265 ENOG4108V1T peptidylprolyl cis-trans isomerase LI89_02275 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic LI89_02280 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase LI89_02285 ENOG4108UUE Transcriptional regulator LI89_02290 ENOG41061GZ Protein of unknown function (DUF1107) LI89_02295 ENOG4105C37 (CBS) domain LI89_02300 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LI89_02315 ENOG4108ZHD aig2 family LI89_02320 ENOG4105F0N pyrophosphate phospho-hydrolase LI89_02325 ENOG4105C8Q Methyl-accepting chemotaxis LI89_02330 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 LI89_02335 ENOG4105DFU Cell wall formation (By similarity) LI89_02345 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) LI89_02350 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LI89_02355 ENOG4105HVQ Regulatory factor of maltose metabolism LI89_02365 ENOG4105EAH synthase LI89_02370 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) LI89_02375 ENOG4105K46 50S ribosomal protein l27 LI89_02380 ENOG4105QYV Membrane LI89_02385 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control LI89_02400 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase LI89_02405 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LI89_02410 ENOG4105HBR Rna-binding protein LI89_02415 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) LI89_02420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) LI89_02425 ENOG4105EEI dihydropteroate synthase LI89_02430 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) LI89_02450 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) LI89_02455 ENOG4105CHV Transcription elongation factor NusA LI89_02460 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LI89_02465 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) LI89_02470 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) LI89_02475 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) LI89_02480 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) LI89_02490 ENOG4105C1J atp-dependent rna helicase LI89_02500 ENOG4105DEN Luciferase family LI89_02505 ENOG4105C1P efflux transporter, rnd family, mfp subunit LI89_02510 ENOG4105BZS acriflavin resistance protein LI89_02515 ENOG4105ENJ RND efflux system, outer membrane lipoprotein LI89_02520 ENOG4105C44 Serine transporter LI89_02525 ENOG4105CEM UPF0597 protein LI89_02530 ENOG4106RZ4 Peptidase U32 LI89_02535 ENOG4105CFP Peptidase U32 LI89_02540 ENOG4105XPQ lipid carrier protein LI89_02545 ENOG4108YYD acetyltransferase LI89_02550 ENOG41082IR Excinuclease ABC C subunit domain protein LI89_02555 ENOG4105D5Q Arginine ornithine antiporter LI89_02560 ENOG4105CXN decarboxylase LI89_02570 ENOG4105EY3 heparinase II III family protein LI89_02585 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component LI89_02590 ENOG4105DRS transport system, permease LI89_02605 ENOG4108ZPB UPF0306 protein LI89_02615 ENOG4105K4T epimerase LI89_02620 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein LI89_02625 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) LI89_02630 ENOG4105FD8 phosphonate metabolism protein PhnM LI89_02635 ENOG4105HRV phosphonate c-p lyase system protein phnl LI89_02640 ENOG4105ENV phosphonate C-P lyase system protein PhnK LI89_02645 ENOG4105FT8 Phosphonate metabolism LI89_02650 ENOG4105EKV Phosphonate metabolism protein LI89_02655 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH LI89_02660 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG LI89_02665 ENOG4107RJJ Transcriptional regulator LI89_02680 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) LI89_02685 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase LI89_02690 ENOG410642W LysR family Transcriptional regulator LI89_02695 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein LI89_02710 ENOG4108JQ7 (ABC) transporter LI89_02715 ENOG4105C3U ABC transporter LI89_02720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LI89_02725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LI89_02735 ENOG4105XEP YhcH YjgK YiaL family protein LI89_02745 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) LI89_02750 ENOG4108MJ3 acetyltransferase LI89_02760 ENOG4105MYG DNA polymerase iii, chi subunit LI89_02765 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) LI89_02770 ENOG4108M8S permease YjgP YjgQ family protein LI89_02775 ENOG4108K5H permease YjgP YjgQ family protein LI89_02790 ENOG4107QMH DNA methylase LI89_02795 ENOG4105D8D Type III LI89_02905 ENOG4105RI1 glycoprotein receptor LI89_02915 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound LI89_02920 ENOG41061GT Aldolase LI89_02925 ENOG4105D4B ABC, transporter LI89_02930 ENOG4105F5R ABC transporter LI89_02935 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane LI89_02940 ENOG4105C2J ABC transporter LI89_02945 ENOG4105DKT Transcriptional regulator LI89_02950 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) LI89_02955 ENOG4105DKP glycosyl transferase, family 9 LI89_02970 ENOG4105D5Q Arginine ornithine antiporter LI89_02975 ENOG4105CEU Arginine dihydrolase LI89_02980 ENOG410624X efflux transporter, rnd family, mfp subunit LI89_02985 ENOG4105BZS acriflavin resistance protein LI89_02995 ENOG4105CMT Dihydroxyacetone kinase LI89_03000 ENOG4108UTZ Dihydroxyacetone kinase LI89_03005 ENOG4105VDH Dihydroxyacetone kinase LI89_03045 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family LI89_03055 ENOG4108HKT sucrose-6-phosphate hydrolase LI89_03070 ENOG4105D7K pfkb domain protein LI89_03080 ENOG4105GAV receptor LI89_03085 ENOG4106TD9 Diguanylate cyclase LI89_03090 ENOG4105YBH Protein of unknown function (DUF1435) LI89_03110 ENOG4105CPC Aldo Keto reductase LI89_03115 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) LI89_03120 ENOG4108WPU DNA polymerase III subunit psi LI89_03125 ENOG4105KEG ribosomal-protein-alanine acetyltransferase LI89_03130 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) LI89_03135 ENOG4105K3G Periplasmic Protein LI89_03145 ENOG4108NRW Phospholipase, patatin family LI89_03150 ENOG4105EYA deoxyribonuclease LI89_03155 ENOG4105D9N nucleoside LI89_03160 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LI89_03165 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) LI89_03170 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) LI89_03175 ENOG4105D3A purine nucleoside phosphorylase DeoD-type LI89_03180 ENOG41062Z9 Membrane LI89_03185 ENOG4105EAC phosphoserine phosphatase LI89_03190 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) LI89_03200 ENOG4105EQR Transposase IS116 IS110 IS902 LI89_03210 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase LI89_03215 ENOG4105CIS alcohol dehydrogenase LI89_03225 ENOG4105C5H ABC transporter LI89_03230 ENOG41090EK ompa motb domain protein LI89_03235 ENOG4108KHX Diguanylate cyclase LI89_03250 ENOG4107SC1 transglycosylase LI89_03255 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) LI89_03260 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LI89_03265 ENOG4105CVJ phosphoglycerate mutase LI89_03270 ENOG4105UEI Transcriptional Regulator AraC Family LI89_03275 ENOG4108RH0 Crea protein LI89_03280 ENOG41065U4 response regulator LI89_03285 ENOG410759A LI89_03295 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) LI89_03305 ENOG4105D1Q UPF0246 protein LI89_03310 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LI89_03315 ENOG4108RIR Molybdenum cofactor biosynthesis protein LI89_03320 ENOG4105CSH Transporter LI89_03330 ENOG4106HK8 GPR1 FUN34 yaaH family protein LI89_03340 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) LI89_03345 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) LI89_03350 ENOG41063Z6 transcriptional regulator, lysR family LI89_03355 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) LI89_03360 ENOG4105DTN riboflavin biosynthesis protein ribF LI89_03365 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) LI89_03370 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) LI89_03375 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase LI89_03380 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) LI89_03385 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) LI89_03390 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LI89_03395 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LI89_03400 ENOG4105N14 lysine exporter protein LysE YggA LI89_03405 ENOG4105DWK Membrane LI89_03410 ENOG4107XM3 UPF0442 protein LI89_03415 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LI89_03420 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) LI89_03425 ENOG4105NWN ApaG protein LI89_03430 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) LI89_03435 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) LI89_03440 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) LI89_03445 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) LI89_03450 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) LI89_03455 ENOG4105D3G Pseudouridine synthase LI89_03465 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) LI89_03475 ENOG4105CQ2 DNA polymerase LI89_03480 ENOG4108KF1 Membrane LI89_03490 ENOG4106SMU thiamine transporter membrane protein LI89_03495 ENOG4105DP9 ABC transporter LI89_03510 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) LI89_03515 ENOG4105F1A Pyruvate formate-lyase LI89_03520 ENOG4105C6N Formate acetyltransferase LI89_03525 ENOG4105S8Q sugar efflux transporter LI89_03530 ENOG4105CIC tryptophan-specific transport protein LI89_03535 ENOG4105C0F tryptophanase EC 4.1.99.1 LI89_03550 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) LI89_03555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) LI89_03560 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) LI89_03565 ENOG41064T2 transcriptional regulator, lysR family LI89_03570 ENOG4108IQE Amp-dependent synthetase and ligase LI89_03575 ENOG4105C7K acetolactate synthase LI89_03580 ENOG4108ZP8 Acetolactate synthase small subunit LI89_03585 ENOG4107B7Y DNA-binding transcriptional regulator FruR LI89_03595 ENOG4108V6E Cell division protein mraZ LI89_03600 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) LI89_03605 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) LI89_03610 ENOG4105CJN penicillin-binding protein LI89_03615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) LI89_03620 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) LI89_03625 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) LI89_03635 ENOG4105CNI cell division protein FtsW LI89_03640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LI89_03645 ENOG4105DFU Cell wall formation (By similarity) LI89_03655 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) LI89_03660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) LI89_03665 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) LI89_03680 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) LI89_03685 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving LI89_03690 ENOG4105M6F mutator MutT protein LI89_03695 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) LI89_03700 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) LI89_03705 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) LI89_03710 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LI89_03715 ENOG4105D7Q type ii secretion system LI89_03720 ENOG4107QHF type ii secretion system protein e LI89_03725 ENOG4108ZUW Major pilin subunit LI89_03730 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase LI89_03740 ENOG4106A72 regulatory protein AmpE LI89_03745 ENOG4105C85 amino acid LI89_03750 ENOG41073TP transcriptional regulator LI89_03755 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) LI89_03760 ENOG4107QSN dihydrolipoamide acetyltransferase LI89_03765 ENOG4107QN2 dihydrolipoyl dehydrogenase LI89_03780 ENOG4107RNH Outer membrane receptor FepA LI89_03785 ENOG4107QIJ Aconitate hydratase 2 LI89_03790 ENOG4108ZIG UPF0231 protein LI89_03795 ENOG4105RPH Inner membrane protein YddG LI89_03825 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) LI89_03830 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) LI89_03835 ENOG4108ZRK uncharacterized protein yacC LI89_03840 ENOG4105E3B Multicopper oxidase LI89_03850 ENOG4108UGV hypoxanthine phosphoribosyltransferase LI89_03855 ENOG41077A9 carbonic anhydrase LI89_03860 ENOG4105DA5 (ABC) transporter LI89_03865 ENOG4105E3A (ABC) transporter LI89_03870 ENOG4107BJW polysaccharide deacetylase LI89_03875 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) LI89_03880 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) LI89_03885 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) LI89_03890 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase LI89_03895 ENOG4105DJ0 Poly(A) Polymerase LI89_03905 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters LI89_03910 ENOG4105PW4 Sugar fermentation stimulation protein homolog LI89_03915 ENOG4107XID 2'-5' rna ligase LI89_03920 ENOG4105CQ7 ATP-dependent helicase LI89_03925 ENOG4105BZ4 penicillin-binding protein LI89_03930 ENOG4105E0A ABC, transporter LI89_03935 ENOG4105J76 Periplasmic binding protein LI89_03940 ENOG4105S6R Iron-hydroxamate transporter permease subunit LI89_03945 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase LI89_03955 ENOG4108YX9 iron--sulfur cluster insertion protein erpA LI89_03960 ENOG4105EN6 Membrane LI89_03970 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) LI89_03975 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein LI89_03980 ENOG4105C0H protease LI89_03985 ENOG4105BZU Histidine kinase LI89_03990 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LI89_03995 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LI89_04000 ENOG4105DXN mazG family LI89_04005 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) LI89_04010 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) LI89_04040 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) LI89_04045 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase LI89_04050 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) LI89_04055 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) LI89_04060 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) LI89_04075 ENOG4108MXK alkaline phosphatase isozyme conversion LI89_04080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LI89_04085 ENOG4105C11 sulfate adenylyltransferase), subunit 2 LI89_04090 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) LI89_04095 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) LI89_04100 ENOG4105N0Z inner membrane protein ygbE LI89_04110 ENOG4105DRP amino acid AbC transporter LI89_04115 ENOG4106PMH Extracellular solute-binding protein family 3 LI89_04120 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) LI89_04130 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) LI89_04135 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) LI89_04140 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) LI89_04145 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) LI89_04150 ENOG4108K5P (LipO)protein LI89_04155 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LI89_04160 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) LI89_04185 ENOG4106PG1 outer membrane usher protein LI89_04190 ENOG4108FZ9 Chaperone LI89_04200 ENOG4105NEV Fimbrial LI89_04205 ENOG4105H8W Fimbrial protein LI89_04230 ENOG4108JJA ABC, transporter LI89_04235 ENOG4105DJY efflux transporter, rnd family, mfp subunit LI89_04245 ENOG4105ENJ RND efflux system, outer membrane lipoprotein LI89_04250 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LI89_04265 ENOG4105CHR reductase LI89_04285 ENOG4105W8I Transcriptional regulator LI89_04295 ENOG4105C6Z Gluconate LI89_04300 ENOG4105BZC d-serine deaminase LI89_04305 ENOG4105EAB amino acid AbC transporter LI89_04310 ENOG4105E5Q amino acid AbC transporter LI89_04315 ENOG4105E5Q amino acid AbC transporter LI89_04320 ENOG4105CDA abc transporter atp-binding protein LI89_04325 ENOG4105CE7 Amidase, hydantoinase carbamoylase family LI89_04330 ENOG4105EIG urea carboxylase-associated protein 1 LI89_04345 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) LI89_04350 ENOG4105YVS arsR family transcriptional regulator LI89_04355 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein LI89_04360 ENOG4105F3R pts system mannose fructose sorbose family iid LI89_04365 ENOG4105ETZ PTS System LI89_04370 ENOG4105KPI PTS system sorbose subfamily IIB component LI89_04375 ENOG4108XCU pts system LI89_04380 ENOG4105DKT Transcriptional regulator LI89_04405 ENOG4108IV0 ABC, transporter LI89_04410 ENOG4108IUZ ABC transporter LI89_04415 ENOG4105CF8 branched-chain amino acid ABC transporter, permease LI89_04420 ENOG4105C32 Amino acid ABC transporter (Permease) LI89_04430 ENOG4107GFK fumarate LI89_04435 ENOG4105CMG Carbohydrate kinase LI89_04440 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase LI89_04450 ENOG4105CNN ABC, transporter LI89_04455 ENOG4105C2J ABC transporter LI89_04465 ENOG4105E98 transcriptional regulator DeoR family LI89_04470 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase LI89_04475 ENOG4107EDW L-fucose operon activator LI89_04485 ENOG4105CMG Carbohydrate kinase LI89_04490 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) LI89_04495 ENOG4105EDR glucose galactose transporter LI89_04500 ENOG4107W7X Aldolase LI89_04505 ENOG4105C0A alcohol dehydrogenase LI89_04510 ENOG4107QY8 reductase LI89_04515 ENOG4105QAX Iron-sulfur LI89_04520 ENOG4107KGK dmso reductase anchor subunit LI89_04525 ENOG4108NEM leader-binding protein dmsD LI89_04540 ENOG4105ETE Transcriptional regulator (LacI family LI89_04550 ENOG4105C2J ABC transporter LI89_04555 ENOG4105CNN ABC, transporter LI89_04560 ENOG4108HHA Transketolase LI89_04565 ENOG4108IUS Transketolase LI89_04570 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) LI89_04595 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) LI89_04600 ENOG4105Y3E Modulates RecA activity (By similarity) LI89_04605 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LI89_04610 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) LI89_04635 ENOG4107VXZ Hydrolase LI89_04640 ENOG4105W39 Membrane LI89_04645 ENOG4105D9M gamma-glutamylcysteine synthetase LI89_04650 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) LI89_04655 ENOG4108JU6 CBS domain protein LI89_04660 ENOG4106KVJ cytochrome C assembly protein LI89_04665 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY LI89_04670 ENOG4105K5M 30s ribosomal protein S16 LI89_04675 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) LI89_04680 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) LI89_04685 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) LI89_04690 ENOG4108NE3 Salt-induced outer membrane protein LI89_04695 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter LI89_04700 ENOG4108NEV two component transcriptional regulator, LytTR family LI89_04705 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) LI89_04710 ENOG4105EHE chorismate mutase- prephenate dehydrogenase LI89_04715 ENOG4105CQC Prephenate dehydratase LI89_04720 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA LI89_04725 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane LI89_04730 ENOG4105C34 Pseudouridine synthase LI89_04735 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase LI89_04740 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LI89_04785 ENOG4105T42 (LipO)protein LI89_04790 ENOG4105JIM Phosphatidylserine synthase LI89_04795 ENOG4105CD5 CoA-binding domain protein LI89_04800 ENOG4106IUH DTW domain containing protein LI89_04805 ENOG4105K63 Thioredoxin LI89_04810 ENOG4105EIB trna rrna methyltransferase LI89_04815 ENOG4105C0R drug resistance transporter emrb qaca subfamily LI89_04820 ENOG4105CW7 secretion protein, HlyD family LI89_04825 ENOG4105ETP RND efflux system, outer membrane lipoprotein LI89_04830 ENOG4105NTK Transcriptional repressor Mpra LI89_04835 ENOG4105ZED uncharacterized protein ygaH LI89_04840 ENOG4108UMN azlc family LI89_04845 ENOG4105EQ0 Major Facilitator superfamily LI89_04865 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) LI89_04880 ENOG4105E5Q amino acid AbC transporter LI89_04885 ENOG4105E5Q amino acid AbC transporter LI89_04895 ENOG4105C5R Aminotransferase LI89_04910 ENOG4105CHM Aminotransferase LI89_04915 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) LI89_04920 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) LI89_04925 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) LI89_04930 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) LI89_04935 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) LI89_04950 ENOG4106YJS accessory processing protein LI89_04955 ENOG4107QPN acyl-Coa dehydrogenase LI89_04960 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) LI89_04965 ENOG4105E7A Glutamine amidotransferase LI89_04970 ENOG4105F7V ErfK ybiS ycfS ynhG family protein LI89_04975 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) LI89_04980 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) LI89_04985 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) LI89_04990 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) LI89_04995 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) LI89_05000 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) LI89_05005 ENOG4105CJ2 (LipO)protein LI89_05020 ENOG4105CPF Cell wall formation (By similarity) LI89_05025 ENOG4105WWK YheO domain protein LI89_05040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LI89_05045 ENOG4105CIN aminoacyl-histidine dipeptidase LI89_05050 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) LI89_05055 ENOG4105V1F Fermentation respiration switch protein LI89_05060 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) LI89_05065 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) LI89_05070 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) LI89_05075 ENOG4105FDP GntR family transcriptional regulator LI89_05080 ENOG4105CI1 PTS System LI89_05085 ENOG4105F8D glycoside hydrolase family 4 LI89_05095 ENOG4105E2V Glycosyltransferase 36 LI89_05110 ENOG4105F2W methyltransferase LI89_05125 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) LI89_05135 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) LI89_05140 ENOG4105NBK UPF0345 protein LI89_05145 ENOG4105DH7 May be involved in recombination (By similarity) LI89_05150 ENOG4105DKQ ROK family LI89_05155 ENOG4105EYH Exonuclease LI89_05160 ENOG4107RH8 nuclease SbcCD subunit D LI89_05165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LI89_05170 ENOG4105BZU Histidine kinase LI89_05180 ENOG4105CWM branched-chain amino acid transport system II carrier protein LI89_05185 ENOG4105C85 amino acid LI89_05190 ENOG4107R28 alpha amylase, catalytic region LI89_05195 ENOG4105CHR reductase LI89_05205 ENOG4105D3R alkyl hydroperoxide reductase LI89_05210 ENOG4108ZYK Acyl carrier protein phosphodiesterase LI89_05215 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) LI89_05225 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) LI89_05230 ENOG4105VIE preprotein translocase, subunit YajC LI89_05235 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) LI89_05240 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) LI89_05250 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) LI89_05255 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) LI89_05260 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) LI89_05265 ENOG4107YIM Involved in the transcription termination process (By similarity) LI89_05270 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) LI89_05275 ENOG4108ZAI phosphatidylglycerophosphatase a LI89_05280 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) LI89_05285 ENOG4105CTB Polyprenyl synthetase LI89_05290 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LI89_05295 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) LI89_05300 ENOG4107S0N DJ-1 family LI89_05305 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LI89_05310 ENOG4108VPT UPF0234 protein LI89_05315 ENOG4107RDB Major Facilitator LI89_05320 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) LI89_05325 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) LI89_05330 ENOG4105CCU oxidase (Subunit III) LI89_05335 ENOG4105BZ9 Cytochrome C oxidase, subunit I LI89_05340 ENOG4105E2S oxidase) subunit II LI89_05350 ENOG4108NFH Sugar hydrolase LI89_05355 ENOG4105EYM Major Facilitator superfamily LI89_05360 ENOG4105IEY (LipO)protein LI89_05365 ENOG4105M85 Bola protein LI89_05370 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation LI89_05375 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LI89_05380 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) LI89_05385 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) LI89_05390 ENOG4105K70 DNA-binding protein LI89_05400 ENOG4105EIN peptidylprolyl cis-trans isomerase LI89_05405 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein LI89_05410 ENOG4108TGP Thioesterase superfamily protein LI89_05415 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) LI89_05420 ENOG4108NFA extracellular solute-binding protein LI89_05425 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) LI89_05435 ENOG4108XM1 transcriptional regulator AsnC family LI89_05440 ENOG4105BZ1 (ABC) transporter LI89_05445 ENOG4105BZ1 (ABC) transporter LI89_05450 ENOG4108YZA Nitrogen regulatory protein pii LI89_05455 ENOG4105BZU Histidine kinase LI89_05460 ENOG4105C29 acyl-CoA thioesterase LI89_05470 ENOG4108MNP Glycoprotein polysaccharide metabolism LI89_05475 ENOG41080UX Methyltransferase LI89_05480 ENOG4105KF5 hemolysin expression-modulating protein LI89_05485 ENOG4108UKR Biofilm formation regulator YbaJ LI89_05500 ENOG4105DIK (ABC) transporter LI89_05505 ENOG4105CC5 ABC transporter LI89_05510 ENOG4105DSE periplasmic solute binding protein LI89_05515 ENOG4105YK5 50S ribosomal protein L36 LI89_05520 ENOG4105NRA 50s ribosomal protein l31 type b LI89_05525 ENOG4106M0N transport system permease protein LI89_05530 ENOG4105MUZ Protein of unknown function DUF2620 LI89_05535 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) LI89_05540 ENOG4108626 Racemase LI89_05550 ENOG4105BZS acriflavin resistance protein LI89_05555 ENOG4105C1P efflux transporter, rnd family, mfp subunit LI89_05560 ENOG4108IG5 Transcriptional regulator LI89_05565 ENOG41090EX DsrE family LI89_05570 ENOG4105EGS Mechanosensitive ion channel LI89_05575 ENOG4106428 Protein of unknown function (DUF2496) LI89_05585 ENOG4105WD1 Membrane LI89_05590 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LI89_05595 ENOG4107QMP dna polymerase iii subunits gamma and tau LI89_05600 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) LI89_05605 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) LI89_05610 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) LI89_05615 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LI89_05620 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) LI89_05625 ENOG4105ER6 polysaccharide biosynthesis protein LI89_05640 ENOG4105CG5 Glycosyl transferase (Group 1 LI89_05645 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LI89_05665 ENOG4105CMR udp-glucose 4-epimerase LI89_05670 ENOG4107RE1 Inosine-guanosine kinase LI89_05675 ENOG4105CKD glutathione-regulated potassium-efflux system protein LI89_05680 ENOG4105EU0 Major facilitator Superfamily LI89_05685 ENOG4105CGH 5'-nucleotidase LI89_05690 ENOG4108Z66 YbaK ebsC protein LI89_05695 ENOG4105MBR gumn family LI89_05700 ENOG4105C59 p-type ATPase LI89_05705 ENOG4108Z6Z Transcriptional regulator LI89_05710 ENOG4105G5H Membrane LI89_05715 ENOG4107QX8 SPFH domain, Band 7 family protein LI89_05720 ENOG4107QR8 Thioredoxin LI89_05725 ENOG4105E1F short-chain dehydrogenase reductase LI89_05730 ENOG4108UJV acyl-CoA thioesterase i LI89_05735 ENOG4108I0Y (ABC) transporter LI89_05740 ENOG4105CV6 ABC transporter, permease LI89_05745 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit LI89_05750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) LI89_05755 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) LI89_05760 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) LI89_05765 ENOG4105C8N cysteinyl-tRNA synthetase LI89_05770 ENOG4105WQ3 Rna-binding protein LI89_05775 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) LI89_05795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LI89_05830 ENOG4105GR3 Histidine kinase LI89_05840 ENOG4105ENX hydrolase LI89_05855 ENOG4105EZE Cupin 4 family protein LI89_05860 ENOG4105C84 Histidine ammonia-lyase LI89_05865 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) LI89_05875 ENOG4108JJ7 ABC transporter LI89_05890 ENOG4108R1E Serine threonine protein phosphatase 1 LI89_05900 ENOG4108N8T regulatoR LI89_05910 ENOG4105VEQ Cold shock protein LI89_05915 ENOG4107Z6W Protein CrcB homolog LI89_05920 ENOG4105BZU Histidine kinase LI89_05925 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) LI89_05930 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) LI89_05935 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) LI89_05940 ENOG4108Z43 UPF0250 protein LI89_05945 ENOG4105DZ1 carboxypeptidase LI89_05950 ENOG4105K6T rare lipoprotein A LI89_05955 ENOG4105CNI cell division protein FtsW LI89_05960 ENOG4105CJN penicillin-binding protein LI89_05970 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) LI89_05975 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) LI89_05980 ENOG4105DJF DNA polymerase III, delta' subunit LI89_05985 ENOG4108U2H Rare lipoprotein B LI89_05990 ENOG4105C8T Leucyl-tRNA synthetase LI89_05995 ENOG4107PAI alpha helical protein LI89_06005 ENOG4105CDA abc transporter atp-binding protein LI89_06010 ENOG4105DRP amino acid AbC transporter LI89_06015 ENOG4105EAD ABC transporter LI89_06020 ENOG4107RP9 extracellular solute-binding protein, family 3 LI89_06030 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) LI89_06035 ENOG4108JU5 Magnesium and cobalt efflux protein LI89_06040 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) LI89_06045 ENOG4105C9A Phoh family LI89_06050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) LI89_06055 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family LI89_06090 ENOG4105CAQ asparagine synthetase LI89_06095 ENOG4105D4U had-superfamily hydrolase, subfamily iia LI89_06100 ENOG4105E2R ROK family LI89_06105 ENOG4105CE4 GlcNAc 6-P deacetylase LI89_06110 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LI89_06115 ENOG4105CI1 PTS System LI89_06120 ENOG4105CX6 glutaminyL-tRNA synthetase LI89_06130 ENOG4105GX6 (LipO)protein LI89_06140 ENOG41090R7 Ferric uptake LI89_06145 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) LI89_06150 ENOG4105C8Q Methyl-accepting chemotaxis LI89_06155 ENOG4105NNH LexA regulated protein LI89_06160 ENOG4105EV9 Alpha Beta Hydrolase LI89_06170 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 LI89_06185 ENOG4105EEX Two component transcriptional regulator (Winged helix family LI89_06190 ENOG4105C08 Histidine kinase LI89_06195 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) LI89_06200 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) LI89_06205 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) LI89_06215 ENOG4105XIQ Protein of unknown function (DUF2517) LI89_06225 ENOG4108RC6 RTX toxin LI89_06230 ENOG4105EUK rtx toxin RtxA LI89_06230 ENOG4105EUK rtx toxin RtxA LI89_06235 ENOG4107SEY Conserved Protein LI89_06240 ENOG4105CVP deoxyribo-dipyrimidine photolyase LI89_06245 ENOG4107RF4 Phosphodiesterase LI89_06250 ENOG4107QNR UPF0135 protein LI89_06260 ENOG4105P4J Allophanate hydrolase, subunit 1 LI89_06265 ENOG4107R7A Allophanate hydrolase subunit 2 LI89_06270 ENOG4105E7W lamb ycsf family protein LI89_06285 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) LI89_06290 ENOG4105BZN citrate synthase LI89_06295 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit LI89_06300 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein LI89_06310 ENOG4105E33 succinate dehydrogenase LI89_06315 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 LI89_06320 ENOG4105C7S Dehydrogenase LI89_06325 ENOG4105CMV Succinyl-CoA synthetase subunit beta LI89_06330 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha LI89_06335 ENOG4105CGH 5'-nucleotidase LI89_06340 ENOG4105C4M (Ubiquinol oxidase) subunit I LI89_06345 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LI89_06355 ENOG4105KJB cyd operon protein YbgE LI89_06360 ENOG4107YD3 Thioesterase LI89_06365 ENOG4105E02 MotA TolQ exbB proton channel LI89_06370 ENOG4105M8F Biopolymer transport protein exbD tolR LI89_06375 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA LI89_06375 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA LI89_06380 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) LI89_06385 ENOG4105KCK Peptidoglycan-associated lipoprotein LI89_06390 ENOG4105UFD tol-pal system protein YbgF LI89_06415 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) LI89_06420 ENOG4106Z1T Nicotinamide Mononucleotide Transporter LI89_06425 ENOG4105PGM cation diffusion facilitator family transporter LI89_06430 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) LI89_06435 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LI89_06450 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LI89_06455 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LI89_06460 ENOG4105F0Z galactose-1-phosphate uridylyltransferase LI89_06465 ENOG4105CMR udp-glucose 4-epimerase LI89_06475 ENOG4105DKW ABC transporter LI89_06480 ENOG4105F4R Transcriptional regulator mode LI89_06485 ENOG410680R Protein of unknown function (DUF2592) LI89_06490 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein LI89_06495 ENOG4105E0C molybdate abc transporter LI89_06505 ENOG4108K4B hydrolase LI89_06510 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LI89_06520 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) LI89_06525 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) LI89_06530 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) LI89_06535 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) LI89_06545 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) LI89_06550 ENOG4105VYA Uncharacterized conserved protein (DUF2132) LI89_06555 ENOG4105CHW UPF0052 protein LI89_06560 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LI89_06565 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LI89_06570 ENOG4105M00 molybdopterin converting factor, subunit 1 LI89_06575 ENOG4108ZAF Molybdopterin LI89_06580 ENOG4105HFZ Membrane LI89_06585 ENOG4107QWP ABC-2 type transporter LI89_06590 ENOG4107QWP ABC-2 type transporter LI89_06595 ENOG4105CJ1 ABC, transporter LI89_06600 ENOG4105D0S secretion protein (HlyD LI89_06605 ENOG4107MVR Transcriptional regulator LI89_06610 ENOG4105C1J atp-dependent rna helicase LI89_06615 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) LI89_06630 ENOG41061WM D-Alanyl-D-Alanine LI89_06640 ENOG4105CXG d-lactate dehydrogenase LI89_06650 ENOG4105N1F Hnh endonuclease LI89_06660 ENOG4105Y3U Transglycosylase-associated protein LI89_06670 ENOG4105EHI Phosphonate ABC transporter, periplasmic LI89_06685 ENOG4108W15 Protein of unknown function (DUF1456) LI89_06695 ENOG4105C32 Amino acid ABC transporter (Permease) LI89_06700 ENOG4105CNN ABC, transporter LI89_06705 ENOG4105C0Z ABC transporter LI89_06710 ENOG4108IV0 ABC, transporter LI89_06715 ENOG4105KHC sulfurtransferase LI89_06735 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system LI89_06740 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component LI89_06745 ENOG4108IJ8 ABC transporter LI89_06750 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component LI89_06765 ENOG4105HEI LysR family (Transcriptional regulator LI89_06775 ENOG4105FDR Membrane LI89_06790 ENOG4105DVT helicase LI89_06795 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LI89_06800 ENOG4108MTB glycosyl transferase family LI89_06810 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction LI89_06820 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) LI89_06825 ENOG4107SDU Methyl-accepting chemotaxis LI89_06830 ENOG4105CDA abc transporter atp-binding protein LI89_06835 ENOG4105E5Q amino acid AbC transporter LI89_06840 ENOG4107R0W ABC transporter LI89_06845 ENOG4105KSC Transcriptional regulator, TraR DksA family LI89_06850 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction LI89_06855 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) LI89_06890 ENOG4108T1M outer membrane protein x LI89_06915 ENOG4105C5H ABC transporter LI89_06920 ENOG4105D06 uba thif-type nad fad binding protein LI89_06925 ENOG4105CVM Molybdenum cofactor synthesis domain protein LI89_06940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LI89_06970 ENOG4105EGI Transcriptional regulator LI89_06975 ENOG4105CBP Major Facilitator LI89_06980 ENOG4105EUJ GTP cyclohydrolase i LI89_06985 ENOG4105DHF Membrane LI89_06990 ENOG41060NJ transcriptional regulator LI89_07005 ENOG4107SDZ Galactoside transport system permease protein mglC LI89_07010 ENOG4105TMB Formate nitrite transporter LI89_07020 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LI89_07025 ENOG4108RC0 Electron transport protein LI89_07030 ENOG4108MG9 hydrogenase 3 maturation protease LI89_07035 ENOG4105I6X formate hydrogenlyase maturation LI89_07040 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit LI89_07050 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LI89_07055 ENOG4108JPZ Monovalent cation H antiporter subunit D LI89_07060 ENOG4107WQX hydrogenase 4 membrane subunit LI89_07065 ENOG4105D65 subunit l LI89_07070 ENOG4107TDF Formate hydrogenlyase subunit 4 LI89_07075 ENOG4108JPZ Monovalent cation H antiporter subunit D LI89_07080 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) LI89_07085 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) LI89_07095 ENOG4107GZ4 SanA protein LI89_07100 ENOG4107R1I NAD-dependent malic enzyme LI89_07115 ENOG41067MG lrgb family LI89_07120 ENOG4105VAW lrga family LI89_07125 ENOG4105E5W Transporter LI89_07145 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) LI89_07150 ENOG4105D1F ATP-binding protein LI89_07155 ENOG4105DBI uridine monophosphokinase LI89_07165 ENOG4108GAE asmA family LI89_07170 ENOG4105CEE C4-dicarboxylate transporter LI89_07175 ENOG4105EE5 Membrane protein terC LI89_07180 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LI89_07185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LI89_07190 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) LI89_07195 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase LI89_07200 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) LI89_07205 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase LI89_07210 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) LI89_07215 ENOG4105ECC imidazole-glycerol-phosphate dehydratase LI89_07220 ENOG4105CIH Imidazole acetol-phosphate transaminase LI89_07230 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) LI89_07235 ENOG4108535 NAD dependent epimerase/dehydratase family LI89_07240 ENOG4105CNN ABC, transporter LI89_07245 ENOG4105C2J ABC transporter LI89_07250 ENOG4105EQR Transposase IS116 IS110 IS902 LI89_07260 ENOG4107SCQ Iron-containing alcohol dehydrogenase LI89_07270 ENOG4105CUB amino acid LI89_07275 ENOG4105CJB Exodeoxyribonuclease I LI89_07280 ENOG4105E4E Thioester reductase domain-containing protein LI89_07285 ENOG4105DR8 Membrane LI89_07290 ENOG41090HJ UPF0265 protein LI89_07300 ENOG4105CNN ABC, transporter LI89_07310 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator LI89_07325 ENOG4105JZC GHMP kinase LI89_07330 ENOG4107QZB decarboxylase LI89_07335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LI89_07340 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LI89_07345 ENOG4105KTW ethanolamine utilization protein LI89_07350 ENOG4105M3W utilization protein LI89_07360 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) LI89_07370 ENOG4108EKI Dehydrogenase LI89_07375 ENOG4108WBT adenosyltransferase LI89_07380 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml LI89_07390 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) LI89_07400 ENOG4105KNY Microcompartments protein LI89_07410 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit LI89_07415 ENOG4108ZFT Dehydratase small subunit LI89_07420 ENOG4105YCI dehydratase medium subunit LI89_07425 ENOG4105DMB glycerol dehydratase LI89_07430 ENOG4105EHR propanediol utilization protein pduB LI89_07435 ENOG4105KNY Microcompartments protein LI89_07440 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LI89_07445 ENOG4107XVH Transcriptional regulator LI89_07450 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) LI89_07455 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) LI89_07460 ENOG41081F0 Precorrin-8x methylmutase LI89_07465 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) LI89_07470 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase LI89_07475 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase LI89_07480 ENOG4105CIA precorrin-4 C(11)-methyltransferase LI89_07485 ENOG4108P62 biosynthesis protein (CbiG) LI89_07490 ENOG4105E4R Precorrin-3B C17-methyltransferase LI89_07495 ENOG4105QUC reductase LI89_07500 ENOG4107PPM cobalt chelatase LI89_07505 ENOG4105DVK Precorrin-2 c20-methyltransferase LI89_07510 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) LI89_07515 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) LI89_07520 ENOG4108V4M Cobalt abc transporter LI89_07530 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) LI89_07535 ENOG4108YZT Adenosylcobinamide kinase LI89_07545 ENOG4108TGR phosphatase LI89_07550 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) LI89_07555 ENOG4105CN8 Transcriptional regulator LI89_07565 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) LI89_07570 ENOG4105EAA nucleoside LI89_07620 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LI89_07625 ENOG4106EAR Fimbrial protein LI89_07630 ENOG4108VEV chaperone LI89_07705 ENOG4105CDH Citrulline--aspartate ligase LI89_07710 ENOG4105UQX Mate efflux family protein LI89_07720 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LI89_07725 ENOG410667J hydrolase LI89_07730 ENOG4105E98 transcriptional regulator DeoR family LI89_07735 ENOG4107S1E Beta-lactamase LI89_07740 ENOG4107R88 Chemotaxis protein (CheV) LI89_07750 ENOG4105EMU Dehydrogenase LI89_07760 ENOG4105C2J ABC transporter LI89_07770 ENOG4105CNN ABC, transporter LI89_07780 ENOG4108HWW ABC transporter LI89_07815 ENOG4108MQF Chaperone LI89_07840 ENOG4105BZU Histidine kinase LI89_07845 ENOG4108Q9V regulatoR LI89_07875 ENOG4107RRE RNA-directed DNA polymerase LI89_07910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LI89_07915 ENOG4107RCV ABC transporter, permease LI89_07920 ENOG4105C4Y ABC transporter LI89_07925 ENOG4105CXY transporter LI89_07930 ENOG4105BZU Histidine kinase LI89_07935 ENOG4108KX4 response regulator LI89_07940 ENOG4106YYS transcriptional regulatory protein LI89_07945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism LI89_07950 ENOG4105DUA (citrate (pro-3S)-lyase ligase LI89_07955 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) LI89_07960 ENOG4105CI0 Citrate lyase LI89_07965 ENOG4105CHY citrate lyase, alpha LI89_07970 ENOG4105YGP holo-ACP synthase CitX LI89_07975 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase LI89_07980 ENOG4107QPK )-transporter LI89_07985 ENOG4105CG6 trap dicarboxylate transporter dctm subunit LI89_07995 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit LI89_08000 ENOG4108TSE Transferase LI89_08010 ENOG4105C54 Major Facilitator superfamily LI89_08015 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein LI89_08040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LI89_08045 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LI89_08050 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme LI89_08055 ENOG4105D3G Pseudouridine synthase LI89_08065 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) LI89_08075 ENOG4105C2J ABC transporter LI89_08085 ENOG4105CNN ABC, transporter LI89_08090 ENOG4105D7K pfkb domain protein LI89_08095 ENOG4108M3J Dehydrogenase LI89_08100 ENOG4105CMG Carbohydrate kinase LI89_08120 ENOG4108D1K outer membrane usher protein LI89_08125 ENOG4108S1B Periplasmic chaperone protein LI89_08135 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) LI89_08140 ENOG4105D6F Phosphatase LI89_08145 ENOG41061EV selenium-binding protein YdfZ LI89_08160 ENOG4105GSJ Inner membrane protein ylaC LI89_08170 ENOG4105CNT hydrolase family 2 LI89_08175 ENOG4105ETE Transcriptional regulator (LacI family LI89_08180 ENOG4105VEQ Cold shock protein LI89_08190 ENOG4105VZF DsrB protein LI89_08195 ENOG4105C8Q Methyl-accepting chemotaxis LI89_08200 ENOG4108MXC l-carnitine dehydratase bile acid-inducible protein F LI89_08205 ENOG4105KT7 mgtC SapB transporter LI89_08210 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic LI89_08215 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein LI89_08220 ENOG4108VA4 Universal stress protein LI89_08225 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) LI89_08230 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region LI89_08235 ENOG4107RD7 Flagellar Motor Protein, MotA LI89_08240 ENOG4105ER2 Ompa motb domain protein LI89_08245 ENOG4105CBS Chea signal transduction histidine kinase LI89_08250 ENOG4108V3W Chemotaxis protein, CheW LI89_08255 ENOG4105C8Q Methyl-accepting chemotaxis LI89_08260 ENOG4105C8Q Methyl-accepting chemotaxis LI89_08265 ENOG4105BZU Histidine kinase LI89_08275 ENOG4108VYJ response regulator receiver protein LI89_08280 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) LI89_08285 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin LI89_08290 ENOG4105D00 flagellar biosynthetic protein flhB LI89_08295 ENOG4105D7B Flagellar biosynthesis protein flha LI89_08300 ENOG4105W13 flagellar protein LI89_08305 ENOG4105TNG K13735 adhesin invasin LI89_08310 ENOG4105QVD Flagella synthesis protein FlgN LI89_08315 ENOG4105M9M anti-sigma28 factor FlgM LI89_08320 ENOG4105CKS Flagella basal body P-ring formation protein flgA LI89_08325 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) LI89_08330 ENOG4108ZC9 flagellar basal-body rod protein flgc LI89_08335 ENOG4105W00 Flagellar hook capping protein LI89_08340 ENOG4105BZE flagellar hook protein, FlgE LI89_08345 ENOG4108KPB Flagellar basal-body rod protein FlgF LI89_08350 ENOG4105CGA flagellar basal-body rod protein FlgG LI89_08365 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LI89_08375 ENOG4105E1Q flagellar hook-associated protein LI89_08380 ENOG4105DTJ flagellar hook-associated protein LI89_08385 ENOG4105D19 Role in flagellar biosynthesis (By similarity) LI89_08390 ENOG4105VS8 Flagellar biosynthetic protein fliq LI89_08395 ENOG4105CN7 Flagellar biosynthetic protein FliP LI89_08405 ENOG4105DD5 Flagellar motor switch protein LI89_08410 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) LI89_08415 ENOG4107ZI8 flagellar basal body-associated protein flil LI89_08420 ENOG4105WF4 Flagellar hook-length control protein LI89_08425 ENOG4105GSA Flagellar export protein flij LI89_08430 ENOG4108JIR Flagellum-specific ATP synthase LI89_08435 ENOG41090PJ Flagellar assembly protein LI89_08440 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) LI89_08445 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) LI89_08450 ENOG4105VQ0 flagellar hook-basal body complex protein fliE LI89_08460 ENOG4105DHT Metal Dependent Phosphohydrolase LI89_08470 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) LI89_08475 ENOG4105MQ3 flagellar protein FliS LI89_08480 ENOG4105DTS flagellar hook-associated LI89_08485 ENOG4105I03 Flagellin LI89_08495 ENOG4105I03 Flagellin LI89_08500 ENOG4105I03 Flagellin LI89_08505 ENOG4108C80 FliB family LI89_08510 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LI89_08515 ENOG4108M9K flagella biosynthesis protein FliZ LI89_08520 ENOG4105K6H D-cysteine desulfhydrase LI89_08525 ENOG4105EAB amino acid AbC transporter LI89_08530 ENOG4105E5Q amino acid AbC transporter LI89_08535 ENOG4105CDA abc transporter atp-binding protein LI89_08550 ENOG4105C26 Dehydrogenase LI89_08555 ENOG4105CK7 Sodium proline symporter LI89_08575 ENOG4105CS1 NAD(P)H quinone oxidoreductase LI89_08585 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) LI89_08590 ENOG4105C2W permease LI89_08595 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) LI89_08600 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) LI89_08605 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) LI89_08610 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) LI89_08615 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) LI89_08620 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) LI89_08625 ENOG4108R86 Transcriptional regulator LI89_08650 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) LI89_08665 ENOG4105E5K Alpha-amylase LI89_08675 ENOG4105RA2 Membrane LI89_08680 ENOG4105XVG cytoplasmic protein LI89_08685 ENOG4105WH1 Two component transcriptional regulator luxr family LI89_08690 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) LI89_08695 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase LI89_08850 ENOG4105ED4 portal protein LI89_08875 ENOG4105VZ1 Replication Protein LI89_08920 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LI89_09005 ENOG4105CDU Replicative dna helicase LI89_09045 ENOG4105RWQ Protein of unknown function (DUF1364) LI89_09150 ENOG410822N TonB family LI89_09240 ENOG4107TII Recombinase LI89_09255 ENOG4108HCJ Hydrolase LI89_09260 ENOG4106UW1 Major Facilitator superfamily LI89_09270 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase LI89_09285 ENOG4105C85 amino acid LI89_09300 ENOG4108MRH transcriptional regulatory protein LI89_09305 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism LI89_09310 ENOG4105MVE transcriptional regulator LI89_09315 ENOG4105G63 Type III effector Hrp-dependent LI89_09320 ENOG4105FB2 class II Aldolase LI89_09325 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) LI89_09330 ENOG4105CSV Glutaminase LI89_09345 ENOG4107SJW iron permease, FTR1 LI89_09360 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LI89_09370 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LI89_09390 ENOG4105EXG Transcriptional regulator LI89_09395 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LI89_09400 ENOG4108819 ferric iron reductase LI89_09405 ENOG4105H1N peptidase, M24 LI89_09410 ENOG4108TUY outer membrane protein PgaA LI89_09415 ENOG4107BJW polysaccharide deacetylase LI89_09420 ENOG4105CND Glycosyl transferase, family 2 LI89_09425 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD LI89_09440 ENOG4105D5M phosphate starvation-inducible protein LI89_09445 ENOG4105EWV Sodium calcium exchanger membrane region LI89_09455 ENOG4105F27 Major Facilitator LI89_09460 ENOG4107R11 Transcriptional regulator LI89_09465 ENOG4105BZU Histidine kinase LI89_09475 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LI89_09480 ENOG4105C4M (Ubiquinol oxidase) subunit I LI89_09485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LI89_09490 ENOG4105C8Y Acetylornithine aminotransferase LI89_09495 ENOG4105F4X arginine LI89_09505 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) LI89_09510 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) LI89_09525 ENOG4105CI2 imidazolone-5-propionate hydrolase LI89_09530 ENOG4105CZE histidine utilization repressor LI89_09535 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) LI89_09540 ENOG41090B9 response to stress LI89_09545 ENOG4108MEK Metal-binding protein YodA LI89_09560 ENOG4108K5P (LipO)protein LI89_09565 ENOG4105D2N Aldolase LI89_09570 ENOG4105E70 isomerase LI89_09575 ENOG4108YTN IIa component LI89_09580 ENOG4105F3R pts system mannose fructose sorbose family iid LI89_09590 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB LI89_09595 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of LI89_09600 ENOG4105E98 transcriptional regulator DeoR family LI89_09615 ENOG4105FE9 pseudouridine synthase LI89_09620 ENOG4105D6U Sodium Glutamate Symporter LI89_09640 ENOG4105D64 Mechanosensitive ion channel LI89_09645 ENOG4108SHQ Glutathione S-transferase LI89_09670 ENOG4105WT8 Protein of unknown function (DUF1480) LI89_09710 ENOG4105C0R drug resistance transporter emrb qaca subfamily LI89_09720 ENOG4105DY2 Paraquat-inducible protein b LI89_09725 ENOG4105H2K paraquat-inducible protein a LI89_09730 ENOG4108ZGC gaf domain protein LI89_09740 ENOG4105CN1 protease LI89_09745 ENOG4105D0M Protease HtpX homolog LI89_09770 ENOG4105C0R drug resistance transporter emrb qaca subfamily LI89_09775 ENOG4105CAZ oligogalacturonide lyase LI89_09785 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase LI89_09790 ENOG4108ETY sodium dicarboxylate symporter LI89_09795 ENOG4107K5X Membrane-bound metal-dependent hydrolase LI89_09800 ENOG4108PU9 oligogalacturonate-specific porin LI89_09805 ENOG4105WEM extracellular solute-binding protein LI89_09815 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component LI89_09820 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component LI89_09830 ENOG4105CHR reductase LI89_09835 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) LI89_09840 ENOG4105M5J Cupin 2, conserved barrel domain protein LI89_09845 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 LI89_09850 ENOG4107PN8 YfeABCD locus regulator LI89_09855 ENOG4105DEQ transcriptional regulator LI89_09860 ENOG4105CYC Transferase LI89_09865 ENOG4108M7F enoyl-CoA hydratase isomerase LI89_09870 ENOG4105DJT lAO AO transport system ATPase LI89_09875 ENOG4105D5P Methylmalonyl-coA mutase LI89_09880 ENOG4105FGM Fructosamine kinase LI89_09885 ENOG4105CC5 ABC transporter LI89_09890 ENOG4105CC5 ABC transporter LI89_09895 ENOG4105DIK (ABC) transporter LI89_09900 ENOG4105DSE periplasmic solute binding protein LI89_09905 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division LI89_09910 ENOG41082NP Multiple antibiotic resistance LI89_09935 ENOG4108UQV Membrane LI89_09940 ENOG41087WU LI89_09950 ENOG4105C22 threonyL-tRNA synthetase LI89_09955 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) LI89_09960 ENOG41082NX 50s ribosomal protein l35 LI89_09965 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) LI89_09970 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) LI89_09980 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) LI89_09995 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) LI89_10000 ENOG4108V06 Glutathione peroxidase LI89_10005 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) LI89_10010 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase LI89_10015 ENOG4105CKK Glycosyl transferase, family 2 LI89_10020 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) LI89_10025 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) LI89_10030 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) LI89_10035 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) LI89_10040 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) LI89_10045 ENOG4108QBX (LipO)protein LI89_10050 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) LI89_10060 ENOG4107R4I Periplasmic binding protein LI89_10065 ENOG4106QJH hemin transport protein LI89_10070 ENOG4107ENK receptor LI89_10075 ENOG4107F3C Hemin uptake protein LI89_10080 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) LI89_10085 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) LI89_10090 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) LI89_10095 ENOG4105IPI Membrane LI89_10100 ENOG4105CQB FAD linked oxidase domain protein LI89_10105 ENOG4105KA0 thioesterase Superfamily protein LI89_10110 ENOG4108Z4V iron-sulfur cluster assembly LI89_10115 ENOG4105DIW FeS assembly protein SUFB LI89_10120 ENOG4105C3K feS assembly ATPase SufC LI89_10125 ENOG4105JRK feS assembly protein SufD LI89_10135 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) LI89_10140 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein LI89_10145 ENOG4105KMX major outer membrane lipoprotein LI89_10150 ENOG4105CA9 Pyruvate kinase LI89_10170 ENOG4107QI1 Mate efflux family protein LI89_10175 ENOG4108R6K riboflavin synthase, subunit alpha LI89_10180 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase LI89_10185 ENOG4105CZQ inner membrane transport protein YdhC LI89_10190 ENOG4105F52 Transcriptional regulator LI89_10195 ENOG4105ETE Transcriptional regulator (LacI family LI89_10205 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) LI89_10210 ENOG4105K4H Nlp p60 protein LI89_10215 ENOG4105M2J Glutaredoxin LI89_10220 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) LI89_10225 ENOG4108UYE Lactoylglutathione lyase LI89_10230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LI89_10235 ENOG4108WUH Transcriptional regulator, TetR family LI89_10240 ENOG4105DIJ Phosphoethanolamine transferase LI89_10245 ENOG4105XZD Fe-S protein LI89_10250 ENOG4107RGM aldo keto reductase LI89_10255 ENOG4105DSW Fusaric acid resistance protein LI89_10260 ENOG4105Y49 secretion protein, HlyD family LI89_10270 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) LI89_10275 ENOG4108XTF Outer Membrane Lipoprotein LI89_10280 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) LI89_10285 ENOG410642K Lysozyme inhibitor LI89_10290 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) LI89_10295 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) LI89_10305 ENOG4108K3A Glutathione S-transferase LI89_10310 ENOG4108ZR5 Conserved Protein LI89_10315 ENOG41069YE inner membrane protein yohC LI89_10330 ENOG4105DUX Transporter LI89_10335 ENOG4105DUM transcriptional regulator, lysR family LI89_10340 ENOG4105Q4T oxidoreductase LI89_10350 ENOG4108JQ2 peptide transport system atp-binding protein LI89_10355 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein LI89_10360 ENOG4108EU3 peptide transport system, permease LI89_10365 ENOG4108I5W peptide transport system, permease protein LI89_10375 ENOG4106DF6 pertussis toxin subunit 1 LI89_10385 ENOG4105E51 psp operon transcriptional activator LI89_10390 ENOG41087YS Phage shock protein A LI89_10395 ENOG4105YYT phage shock protein B LI89_10400 ENOG4105FM1 phage shock protein C LI89_10410 ENOG4105CM6 amino acid regulated cytosolic protein LI89_10415 ENOG4106K28 UPF0283 membrane protein LI89_10435 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) LI89_10440 ENOG4107S8C mandelate racemase muconate lactonizing LI89_10445 ENOG4105KXI murein peptide amidase A LI89_10450 ENOG4107QSI ABC, transporter LI89_10465 ENOG4107RX3 Mg2 transporter protein cora family protein LI89_10470 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) LI89_10475 ENOG4105CID antiterminator LI89_10480 ENOG4105C5Y PTS System LI89_10485 ENOG4105CS2 ec 3.2.1.21 LI89_10490 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) LI89_10500 ENOG4105KT7 mgtC SapB transporter LI89_10510 ENOG4105C5I Dehydrogenase LI89_10515 ENOG4107H52 Dicarboxylate transport LI89_10520 ENOG410689M (LipO)protein LI89_10525 ENOG4105WXT Conserved Protein LI89_10530 ENOG4105IE8 Alpha-ketoglutarate permease LI89_10535 ENOG4105CMG Carbohydrate kinase LI89_10540 ENOG4105DEI Mannitol dehydrogenase LI89_10550 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LI89_10555 ENOG4105CQ7 ATP-dependent helicase LI89_10570 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap LI89_10585 ENOG4105CTD carboxy-peptidase LI89_10590 ENOG4105JJR Histidine kinase LI89_10595 ENOG4107EXC regulatoR LI89_10605 ENOG4105D5Q Arginine ornithine antiporter LI89_10610 ENOG4105C5D exported protein LI89_10620 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) LI89_10625 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) LI89_10630 ENOG4105Q9Y Universal stress protein LI89_10635 ENOG4105DS0 Transcriptional regulator, Crp Fnr family LI89_10640 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LI89_10655 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) LI89_10665 ENOG4105H9W Short-chain dehydrogenase reductase Sdr LI89_10675 ENOG4108RVA ribokinase LI89_10680 ENOG4105EDR glucose galactose transporter LI89_10700 ENOG4105PAD Hydrolase LI89_10705 ENOG4105M71 acetolactate synthase 1 regulatory subunit LI89_10710 ENOG4105C7K acetolactate synthase LI89_10730 ENOG4105CXY transporter LI89_10740 ENOG4105ETE Transcriptional regulator (LacI family LI89_10745 ENOG4105FYV Amp nucleosidase LI89_10755 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) LI89_10765 ENOG4106V2I dimethylaminohydrolase LI89_10770 ENOG4105E89 ABC transporter LI89_10775 ENOG4105DSP amino acid AbC transporter LI89_10785 ENOG4108RYR transcriptional regulator AsnC family LI89_10795 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase LI89_10800 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center LI89_10805 ENOG4108JUA Transcriptional regulator LI89_10825 ENOG4105CYM Glutathione S-transferase LI89_10855 ENOG4105TDT uncharacterized protein yahO LI89_10860 ENOG4105C0R drug resistance transporter emrb qaca subfamily LI89_10865 ENOG4105EMU Dehydrogenase LI89_10870 ENOG4105KK4 UPF0060 membrane protein LI89_10885 ENOG4105M5Q UPF0482 protein LI89_10890 ENOG4105KBG Protein of unknown function (DUF1161) LI89_10905 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) LI89_10910 ENOG4105DAG ROK family LI89_10915 ENOG4106NZI LysR family Transcriptional regulator LI89_10920 ENOG4105D94 Major Facilitator Superfamily LI89_10935 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) LI89_10945 ENOG4105C9Q fumarate hydratase class II LI89_10950 ENOG4105EIP mannose-6-phosphate isomerase LI89_10955 ENOG4106J39 exported protein LI89_10965 ENOG4107P2S Transcriptional regulator LI89_10970 ENOG4105CI1 PTS System LI89_10975 ENOG4105C87 Aminotransferase class I and II LI89_10980 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) LI89_10985 ENOG4105DHU Bile acid LI89_10990 ENOG4105D9R oxidoreductase LI89_11000 ENOG4105CNN ABC, transporter LI89_11010 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator LI89_11020 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) LI89_11030 ENOG4105C42 Type I secretion membrane fusion protein (HlyD LI89_11045 ENOG4105CKU formyltetrahydrofolate synthetase LI89_11050 ENOG4105M9B inner membrane protein ydgK LI89_11060 ENOG4105DGN Electron transport complex LI89_11070 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) LI89_11075 ENOG4105UEI Transcriptional Regulator AraC Family LI89_11080 ENOG4105D6A Electron transport complex LI89_11085 ENOG4108UQQ Electron transport complex LI89_11095 ENOG4105CSM endonuclease III LI89_11110 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit LI89_11115 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) LI89_11120 ENOG4105D22 carbon starvation protein LI89_11125 ENOG4105VCD cytoplasmic protein LI89_11130 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LI89_11135 ENOG4105N2W Transcriptional regulator LI89_11145 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase LI89_11150 ENOG41061RM osmotically inducible lipoprotein LI89_11155 ENOG4108ZJT translation initiation factor, Sui1 LI89_11160 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) LI89_11170 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction LI89_11175 ENOG4105DKK Benzoate LI89_11180 ENOG4108JCI Transcriptional regulator LI89_11190 ENOG4105CFV Tetratricopeptide repeat protein LI89_11195 ENOG4105Q4A inner membrane protein yciS LI89_11200 ENOG4105EYK Phosphatidylglycerophosphatase B LI89_11205 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) LI89_11210 ENOG4107QM5 aconitate hydratase LI89_11225 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LI89_11300 ENOG4107R11 Transcriptional regulator LI89_11305 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LI89_11310 ENOG4105RKX Protein of unknown function (DUF2498) LI89_11315 ENOG4105ERU peptidase LI89_11320 ENOG4105UBK short-chain dehydrogenase reductase LI89_11325 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase LI89_11335 ENOG4105FE9 pseudouridine synthase LI89_11340 ENOG4107RTD sua5 ycio yrdc ywlc family protein LI89_11345 ENOG4105DB7 PHP domain protein LI89_11355 ENOG4105DDQ anthranilate synthase LI89_11365 ENOG4105DK0 Indole-3-glycerol phosphate synthase LI89_11370 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) LI89_11375 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) LI89_11385 ENOG4105EIF outer membrane protein W LI89_11390 ENOG4105PI0 Ferredoxin LI89_11395 ENOG4108S3I UPF0259 membrane protein LI89_11405 ENOG4107835 probably involved in intracellular septation (By similarity) LI89_11410 ENOG4105NAU thioesterase Superfamily protein LI89_11415 ENOG410822N TonB family LI89_11420 ENOG4105K9H YciI-like protein LI89_11435 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LI89_11440 ENOG4108W5H UPF0263 protein LI89_11445 ENOG4108JQ7 (ABC) transporter LI89_11450 ENOG4105C3U ABC transporter LI89_11455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LI89_11460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LI89_11465 ENOG4107QSI ABC, transporter LI89_11470 ENOG4107QSI ABC, transporter LI89_11475 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein LI89_11480 ENOG4108EKI Dehydrogenase LI89_11485 ENOG4107104 thymidine kinase LI89_11500 ENOG4105C6Y Udp-glucose 6-dehydrogenase LI89_11505 ENOG4105I93 response regulator LI89_11510 ENOG4105D78 K07001 NTE family protein LI89_11520 ENOG4105K5B UPF0225 protein LI89_11525 ENOG4105CIY formyltetrahydrofolate deformylase LI89_11545 ENOG4105SKE transcriptional Regulator LysR family LI89_11550 ENOG4105CGK Exodeoxyribonuclease III LI89_11555 ENOG4105M6F mutator MutT protein LI89_11560 ENOG4105MTM Protein of unknown function (DUF1496) LI89_11565 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LI89_11575 ENOG41069NU Nitroreductase LI89_11580 ENOG4105D07 Signal peptide peptidase, SppA LI89_11585 ENOG4105HDK L-asparaginase LI89_11590 ENOG4108RWI nicotinamidase LI89_11595 ENOG4105VUT cytoplasmic protein LI89_11600 ENOG4105E0X reductase LI89_11610 ENOG4105DSB aldose 1-epimerase LI89_11615 ENOG4105GNX MltA-interacting MipA family protein LI89_11620 ENOG4105CYN Serine protein kinase LI89_11625 ENOG4106AKX UPF0229 protein LI89_11640 ENOG4105HEI LysR family (Transcriptional regulator LI89_11645 ENOG4105EUB pirin domain protein LI89_11650 ENOG4105BZU Histidine kinase LI89_11655 ENOG4105CNH Multidrug resistance protein MdtL LI89_11660 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LI89_11665 ENOG4105MWK D-amino acid dehydrogenase, small subunit LI89_11670 ENOG4105ED1 spovr family LI89_11675 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) LI89_11680 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) LI89_11685 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) LI89_11690 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LI89_11700 ENOG4108ZZ3 UPF0260 protein LI89_11705 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase LI89_11710 ENOG4105CVE Lytic murein transglycosylase LI89_11715 ENOG4105VNG YcgL domain-containing protein LI89_11725 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) LI89_11730 ENOG4107QMS site-determining protein LI89_11735 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) LI89_11740 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) LI89_11745 ENOG4105CEY Amp-dependent synthetase and ligase LI89_11750 ENOG4105Y4Z Outer Membrane Lipoprotein LI89_11755 ENOG41072GX Peptidase M22 Glycoprotease LI89_11760 ENOG4105DVT helicase LI89_11765 ENOG4105M4H endoribonuclease L-psp LI89_11775 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) LI89_11780 ENOG4108UHU Aldolase LI89_11785 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase LI89_11790 ENOG4106KNT transcriptional regulator LI89_11795 ENOG4105CA9 Pyruvate kinase LI89_11800 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase LI89_11805 ENOG4105DR5 peptidase LI89_11810 ENOG4105NXV High-affinity zinc uptake system protein LI89_11815 ENOG4105FDK ABC transporter LI89_11820 ENOG4105FAV ABC, transporter LI89_11825 ENOG4105DUX Transporter LI89_11830 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) LI89_11835 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) LI89_11840 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) LI89_11845 ENOG4105CDY transcriptional regulatory protein LI89_11850 ENOG4108TIT dATP pyrophosphohydrolase LI89_11855 ENOG4105C9M aspartyl-trna synthetase LI89_11860 ENOG4105D3W isochorismatase LI89_11865 ENOG41081XQ Conserved Protein LI89_11870 ENOG4105WJG Glutathione LI89_11875 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) LI89_11880 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) LI89_11885 ENOG4106N3A copper homeostasis protein cutc LI89_11890 ENOG4106ZCM YecM protein LI89_11895 ENOG4105C75 arginyL-tRNA synthetase LI89_11900 ENOG4105CJR Integral membrane protein (MviN LI89_11905 ENOG4105EP9 oxidoreductase LI89_11915 ENOG4105D9U N-acetyltransferase LI89_11945 ENOG4105EV4 Multidrug resistance protein mdtH LI89_11950 ENOG4105F3T (LipO)protein LI89_11955 ENOG4107XHZ cytoplasmic chaperone TorD family protein LI89_11960 ENOG4107SSZ Phosphatase LI89_11965 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase LI89_11985 ENOG4105BZU Histidine kinase LI89_11990 ENOG4105CHH sulfate transporter LI89_11995 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase LI89_12000 ENOG41063JG Transcriptional regulator LI89_12005 ENOG4108YY7 Invasion gene expression up-regulator SirB LI89_12010 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LI89_12015 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) LI89_12020 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) LI89_12025 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) LI89_12035 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LI89_12040 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria LI89_12050 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) LI89_12060 ENOG4105C3G gtp-binding protein LI89_12065 ENOG4105C5I Dehydrogenase LI89_12075 ENOG4105CXK mandelate racemase muconate lactonizing LI89_12080 ENOG4108RTU Aldolase LI89_12085 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 LI89_12090 ENOG4105EMF GntR family transcriptional regulator LI89_12095 ENOG41066YJ Beta-lactamase LI89_12105 ENOG4108Q2J Inner membrane protein YebE LI89_12115 ENOG4105KUS lysozyme LI89_12130 ENOG4105HRS Antitermination protein LI89_12150 ENOG4105C5H ABC transporter LI89_12220 ENOG4105F9F transposase LI89_12230 ENOG4105PTU response to oxidative stress LI89_12315 ENOG4105NKT exported protein LI89_12320 ENOG4108PNC copper resistance LI89_12325 ENOG4105FXM Copper resistance protein LI89_12330 ENOG41090A1 ferritin LI89_12335 ENOG4105MPK DNA polymerase III subunit theta LI89_12350 ENOG4105UMD exodeoxyribonuclease X LI89_12355 ENOG4105CUG Oligopeptidase b LI89_12365 ENOG4105N5Z UPF0267 protein LI89_12370 ENOG4105X2V dna damage-inducible protein LI89_12375 ENOG4105C1J atp-dependent rna helicase LI89_12380 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR LI89_12385 ENOG4105X5C UPF0181 protein LI89_12390 ENOG4105CRQ synthase (Component I) LI89_12395 ENOG4105P8F nudix hydrolase LI89_12400 ENOG4105EJQ L-serine dehydratase LI89_12405 ENOG4105EE5 Membrane protein terC LI89_12410 ENOG4108EQA pts system LI89_12415 ENOG4105ETZ PTS System LI89_12420 ENOG4105F3R pts system mannose fructose sorbose family iid LI89_12425 ENOG4108NK4 UPF0266 membrane protein LI89_12430 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) LI89_12440 ENOG4105BZU Histidine kinase LI89_12450 ENOG4105DHI Methyltransferase LI89_12455 ENOG4105CJN penicillin-binding protein LI89_12460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase LI89_12465 ENOG4105VEQ Cold shock protein LI89_12470 ENOG410610J Protein of unknown function (DUF2627) LI89_12475 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) LI89_12480 ENOG4105C85 amino acid LI89_12495 ENOG41064PC LI89_12500 ENOG4105TIK LI89_12505 ENOG4105N4N Protein of unknown function (DUF2766) LI89_12530 ENOG4105D5Q Arginine ornithine antiporter LI89_12540 ENOG4105BZ1 (ABC) transporter LI89_12570 ENOG4105XXV Acid-resistance protein LI89_12575 ENOG4105VTN Protein of unknown function (DUF1311) LI89_12590 ENOG4105CSP Major Facilitator Superfamily LI89_12595 ENOG4105DIA mandelate racemase muconate lactonizing LI89_12600 ENOG410617M Transcriptional regulator LI89_12605 ENOG4105CPQ Dehydrogenase LI89_12610 ENOG4107QZW Altronate oxidoreductase LI89_12615 ENOG4105CTX dehydratase LI89_12655 ENOG4105KVH Transcriptional regulator LI89_12660 ENOG4105ECR NmrA family LI89_12665 ENOG4108IQK o-acetylhomoserine LI89_12680 ENOG4105QFS Lysis protein S homolog from lambdoid prophage LI89_12685 ENOG4105KUS lysozyme LI89_12700 ENOG4105KT5 UmuD protein LI89_12705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LI89_12720 ENOG4106NDP Transcriptional regulator LI89_12725 ENOG4108HKT sucrose-6-phosphate hydrolase LI89_12760 ENOG4108HMX isocitrate dehydrogenase (NADP) LI89_12765 ENOG4108R99 pseudouridine synthase LI89_12775 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) LI89_12780 ENOG41075W9 High frequency lysogenization protein HflD homolog LI89_12785 ENOG4107QTF adenylosuccinate lyase LI89_12795 ENOG4105XJC Two component transcriptional regulator (Winged helix family LI89_12805 ENOG4105EZE Cupin 4 family protein LI89_12815 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LI89_12820 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) LI89_12830 ENOG4105D60 lipoprotein releasing system transmembrane protein LI89_12840 ENOG4105D60 lipoprotein releasing system transmembrane protein LI89_12845 ENOG4108JA2 transcriptioN-repair coupling factor LI89_12850 ENOG4107MBR 17 kDa surface antigen LI89_12855 ENOG4105CEP NADH dehydrogenase LI89_12860 ENOG4105D0Y UPF0227 protein LI89_12865 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) LI89_12870 ENOG4108RUM thiamine kinase LI89_12875 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) LI89_12880 ENOG41090DQ Lipoprotein LI89_12885 ENOG4105K59 histidine triad (HIT) protein LI89_12890 ENOG4105F9E Shikimate 5-dehydrogenase LI89_12900 ENOG4105CI1 PTS System LI89_12905 ENOG4105F8V Hydrolase, tatD family LI89_12910 ENOG4107QRG dna polymerase iii LI89_12915 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) LI89_12920 ENOG4105HHA aminodeoxychorismate lyase LI89_12925 ENOG4105YAZ 4-amino-4-deoxychorismate lyase LI89_12930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LI89_12940 ENOG4105CHR reductase LI89_12945 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LI89_12950 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LI89_12955 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) LI89_12960 ENOG4105VGS 50s ribosomal protein l32 LI89_12965 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein LI89_12975 ENOG4105EI2 Pseudouridine synthase LI89_12980 ENOG4107QQB Ribonuclease E LI89_12980 ENOG4107QQB Ribonuclease E LI89_12985 ENOG41067V3 Antibiotic biosynthesis monooxygenase LI89_12990 ENOG4105EKE dihydroorotase LI89_13000 ENOG4105PVA Biofilm formation regulatory protein BssS LI89_13015 ENOG4105DSF transport protein LI89_13020 ENOG4105C72 UPF0176 protein LI89_13030 ENOG4105DB1 molybdopterin oxidoreductase LI89_13035 ENOG4106WHD Tetrathionate reductase LI89_13040 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LI89_13045 ENOG4106AFQ Histidine kinase LI89_13050 ENOG4108ZXC Two component transcriptional regulator, luxr family LI89_13055 ENOG4105D1S lipid A biosynthesis LI89_13060 ENOG4108VGI doxx family LI89_13065 ENOG4105C6X Major Facilitator LI89_13070 ENOG4105DUX Transporter LI89_13080 ENOG4105NAC (LipO)protein LI89_13085 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) LI89_13090 ENOG4105DJ9 glucan biosynthesis protein LI89_13105 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) LI89_13115 ENOG4107YC3 synthase LI89_13120 ENOG4105VJY transcriptional regulator LI89_13125 ENOG4108W0S formate-dependent nitrite reductase complex LI89_13135 ENOG4107QX9 Thiol disulfide interChange protein LI89_13140 ENOG4105DA4 cytochrome c-type biogenesis protein LI89_13145 ENOG4105DVI reductase, NrfD LI89_13150 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LI89_13155 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit LI89_13160 ENOG4105EAU Plays a role in nitrite reduction (By similarity) LI89_13175 ENOG4108Z0T Part of a sulfur-relay system (By similarity) LI89_13180 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 LI89_13195 ENOG4105DR4 Methyltransferase LI89_13200 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) LI89_13205 ENOG4105K4P CoA-binding domain protein LI89_13210 ENOG4108Q67 UPF0319 protein LI89_13215 ENOG4108Z5K methylglyoxal synthase LI89_13220 ENOG41088T4 Helicase IV LI89_13225 ENOG410901E Membrane LI89_13230 ENOG4105EM2 membrane LI89_13235 ENOG4108RZ1 DNA transformation protein LI89_13240 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) LI89_13245 ENOG4105UYK outer membrane protein a LI89_13250 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) LI89_13255 ENOG4105DAN ATP-dependent protease LI89_13260 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) LI89_13270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LI89_13275 ENOG4108Q2G (LipO)protein LI89_13280 ENOG4105DY2 Paraquat-inducible protein b LI89_13285 ENOG4105F1S paraquat-inducible protein a LI89_13290 ENOG4105C5H ABC transporter LI89_13295 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) LI89_13300 ENOG4105QVC MOSC domain-containing protein LI89_13305 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) LI89_13310 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) LI89_13315 ENOG4105CD8 aminopeptidase N LI89_13320 ENOG4107RH7 Nicotinate phosphoribosyltransferase LI89_13325 ENOG4105C5S asparaginyl-tRNA synthetase LI89_13335 ENOG4105CGF Aromatic amino acid aminotransferase LI89_13340 ENOG4105BZU Histidine kinase LI89_13345 ENOG4105C5X domain protein LI89_13350 ENOG4105EAQ (twin-arginine translocation) pathway signal LI89_13355 ENOG4105DIT ErfK YbiS YcfS YnhG family protein LI89_13360 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) LI89_13365 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) LI89_13370 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) LI89_13375 ENOG4106371 Methyltransferase LI89_13380 ENOG4107S90 membrAne LI89_13385 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups LI89_13390 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) LI89_13395 ENOG4105W49 UPF0434 protein LI89_13400 ENOG4105VEQ Cold shock protein LI89_13405 ENOG4105VEQ Cold shock protein LI89_13410 ENOG4105E32 cytoplasmic protein LI89_13415 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) LI89_13425 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 LI89_13430 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) LI89_13435 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LI89_13440 ENOG4105CAT Cytidine monophosphate kinase LI89_13445 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase LI89_13450 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) LI89_13455 ENOG4107VMU Membrane LI89_13460 ENOG4105HDK L-asparaginase LI89_13465 ENOG4105DDY UPF0142 protein ycaO LI89_13470 ENOG4105TMB Formate nitrite transporter LI89_13475 ENOG4105C6N Formate acetyltransferase LI89_13480 ENOG4105F1A Pyruvate formate-lyase LI89_13485 ENOG4108ISG Major Facilitator LI89_13490 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) LI89_13495 ENOG4105D1H recombination factor protein RarA LI89_13500 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) LI89_13505 ENOG4105CNU cell division protein FtsK LI89_13510 ENOG4105EW9 transcriptional regulator AsnC family LI89_13515 ENOG4105C3M thioredoxin reductase LI89_13520 ENOG4108JJ9 ABC, transporter LI89_13525 ENOG4108JJ8 (ABC) transporter LI89_13530 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) LI89_13535 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) LI89_13540 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LI89_13545 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) LI89_13550 ENOG4105VEQ Cold shock protein LI89_13560 ENOG4105DJY efflux transporter, rnd family, mfp subunit LI89_13565 ENOG4108MJ5 VirK protein LI89_13570 ENOG4105CPB ATP-dependent endonuclease of the OLD family LI89_13575 ENOG4105DWU Membrane LI89_13580 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) LI89_13585 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) LI89_13590 ENOG4105C7K acetolactate synthase LI89_13600 ENOG4105C5W Aldolase LI89_13605 ENOG4105CGD Nad-dependent epimerase dehydratase LI89_13610 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase LI89_13615 ENOG41064MM (LipO)protein LI89_13620 ENOG4105E5Z arginine transporter ATP-binding subunit LI89_13625 ENOG4106PMH Extracellular solute-binding protein family 3 LI89_13630 ENOG4105GBT ABC transporter LI89_13635 ENOG4105DMR ABC, transporter LI89_13650 ENOG4106TNF Periplasmic binding protein LI89_13655 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) LI89_13660 ENOG4105RBQ inner membrane protein ybjO LI89_13665 ENOG4105D38 putrescine abc transporter LI89_13670 ENOG4105F38 ABC transporter, permease LI89_13675 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LI89_13680 ENOG4107RUE extracellular solute-binding protein family 1 LI89_13685 ENOG4108RMJ sensory transduction regulator LI89_13690 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress LI89_13695 ENOG41090BQ Glutaredoxin LI89_13700 ENOG4105D0C transport protein LI89_13710 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase LI89_13715 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LI89_13720 ENOG4107FB0 transcriptional regulator DeoR family LI89_13725 ENOG4105C44 Serine transporter LI89_13730 ENOG4105EJQ L-serine dehydratase LI89_13735 ENOG4105DZ1 carboxypeptidase LI89_13745 ENOG4105C28 cystathionine LI89_13760 ENOG4108UMI ABC transporter, permease LI89_13770 ENOG4105D01 (LipO)protein LI89_13785 ENOG4108TGY Glutathione S-transferase LI89_13790 ENOG4105D05 Receptor LI89_13800 ENOG4105EHG Permease protein LI89_13805 ENOG4108IQI permease LI89_13810 ENOG4105DUM transcriptional regulator, lysR family LI89_13820 ENOG4105HMI Membrane LI89_13825 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) LI89_13830 ENOG4108D1K outer membrane usher protein LI89_13835 ENOG4108UIF Chaperone LI89_13850 ENOG4108SGD regulatory protein LI89_13855 ENOG4105DM4 PTS System LI89_13860 ENOG4105DE4 1-phosphofructokinase LI89_13865 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein LI89_13875 ENOG4105CUW cytochrome C-TYPE protein LI89_13880 ENOG4107QY8 reductase LI89_13885 ENOG4105KRS Proteinase inhibitor LI89_13895 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LI89_13900 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) LI89_13910 ENOG4105DEI Mannitol dehydrogenase LI89_13915 ENOG4107YCY Transcriptional regulator LI89_13925 ENOG4105CKI cobalamin synthesis protein LI89_13930 ENOG41076MN Phosphoesterase, PA-phosphatase related LI89_13935 ENOG4107TT5 NLP P60 protein LI89_13945 ENOG4105CXC rtn protein LI89_13950 ENOG4105E43 Extracellular solute-binding protein, family 5 LI89_13955 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component LI89_13960 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component LI89_13965 ENOG4108JQ5 ABC transporter LI89_13970 ENOG4105HG6 LI89_13975 ENOG4105C2C drug resistance transporter, Bcr CflA LI89_13980 ENOG4105I08 Pseudouridine synthase LI89_13985 ENOG4105CFI type iii restriction protein res subunit LI89_13995 ENOG4106V8H Nucleoid-associated protein LI89_14000 ENOG4105PAN UPF0352 protein LI89_14005 ENOG4105E68 Sulfatase LI89_14025 ENOG4105CS2 ec 3.2.1.21 LI89_14030 ENOG4105C5Y PTS System LI89_14035 ENOG4108Q3X Transcriptional regulator LI89_14055 ENOG4105Y50 Virulence Protein LI89_14065 ENOG4105C8Q Methyl-accepting chemotaxis LI89_14075 ENOG4105CT4 transporter LI89_14080 ENOG4107R6D beta-lactam binding protein AmpH LI89_14105 ENOG4107QZV Type I secretion membrane fusion protein LI89_14110 ENOG4105BZ1 (ABC) transporter LI89_14125 ENOG4106UW1 Major Facilitator superfamily LI89_14130 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC LI89_14135 ENOG41068CG regulatoR LI89_14140 ENOG4105BZU Histidine kinase LI89_14145 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LI89_14150 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) LI89_14155 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LI89_14160 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LI89_14165 ENOG4105XPH Ferredoxin LI89_14170 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) LI89_14190 ENOG4105E0U tyrosine-specific transport protein LI89_14195 ENOG4108UII YfaZ family LI89_14200 ENOG4105CH6 catalase LI89_14210 ENOG4105CEY Amp-dependent synthetase and ligase LI89_14215 ENOG4105DNI Converts SHCHC to OSB (By similarity) LI89_14220 ENOG4108IPT Naphthoate synthase LI89_14225 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) LI89_14230 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) LI89_14235 ENOG4105E4F Isochorismate synthase LI89_14240 ENOG4105TNS Conserved Protein LI89_14245 ENOG4105C01 Dihydroxy-acid dehydratase LI89_14250 ENOG41090KN UPF0303 protein LI89_14260 ENOG4105C5I Dehydrogenase LI89_14265 ENOG4105K2J Transcriptional regulator LI89_14270 ENOG4105CHR reductase LI89_14275 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family LI89_14295 ENOG4108UQ5 membrane protein YcdZ LI89_14305 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LI89_14310 ENOG4105C8S subunit m LI89_14315 ENOG4105D65 subunit l LI89_14320 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LI89_14325 ENOG4107UFS subunit j LI89_14330 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LI89_14335 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) LI89_14340 ENOG4108IEH NADH dehydrogenase subunit g LI89_14345 ENOG4107QIZ NADH dehydrogenase LI89_14350 ENOG4105GKE subunit e LI89_14355 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LI89_14360 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LI89_14365 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain LI89_14370 ENOG4107NQ8 LysR family Transcriptional regulator LI89_14380 ENOG4105CHM Aminotransferase LI89_14390 ENOG4105DK2 UPF0207 protein LI89_14395 ENOG4107QWE )-transporter LI89_14405 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 LI89_14410 ENOG4105XWI UPF0304 protein LI89_14415 ENOG4105PQ6 UPF0208 membrane protein LI89_14425 ENOG4105C6K Malic enzyme LI89_14430 ENOG4107P2S Transcriptional regulator LI89_14435 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia LI89_14445 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC LI89_14450 ENOG4105PTV Nudix Hydrolase LI89_14455 ENOG4108RE9 Phosphodiesterase LI89_14465 ENOG4105ECP epimerase LI89_14470 ENOG4108JEH abc transporter atp-binding protein LI89_14475 ENOG4106YG3 ABC transporter LI89_14480 ENOG4105DSP amino acid AbC transporter LI89_14485 ENOG4105E89 ABC transporter LI89_14495 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase LI89_14500 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase LI89_14505 ENOG4105E96 Colicin v production protein LI89_14510 ENOG4108S3P Sporulation domain protein LI89_14515 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase LI89_14525 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) LI89_14530 ENOG4105DQR SNARE associated Golgi LI89_14540 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LI89_14545 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) LI89_14555 ENOG410631K Membrane LI89_14570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LI89_14575 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LI89_14595 ENOG4106WZ1 flagella biosynthesis regulator LI89_14600 ENOG4105F4P )-transporter LI89_14605 ENOG4105D6F Phosphatase LI89_14610 ENOG4105ETE Transcriptional regulator (LacI family LI89_14620 ENOG4105CK1 PTS System LI89_14625 ENOG4105CS2 ec 3.2.1.21 LI89_14630 ENOG4105VCP PTS System LI89_14645 ENOG4105BZU Histidine kinase LI89_14650 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LI89_14655 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) LI89_14660 ENOG4105MH2 YfcL protein LI89_14665 ENOG4108BPE -transporting atpase LI89_14670 ENOG4105EJ9 Membrane LI89_14675 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) LI89_14680 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase LI89_14685 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) LI89_14695 ENOG4108DG9 Smr protein MutS2 LI89_14700 ENOG4108BY2 phosphohistidine phosphatase LI89_14705 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase LI89_14710 ENOG4105CHU acetyl-coa acetyltransferase LI89_14715 ENOG4105KZW UPF0381 protein LI89_14720 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation LI89_14735 ENOG410903C (LipO)protein LI89_14740 ENOG4105KWW Biogenesis protein LI89_14745 ENOG4108M1T Cytochrome c-type biogenesis protein LI89_14750 ENOG4107QX9 Thiol disulfide interChange protein LI89_14755 ENOG4105DA4 cytochrome c-type biogenesis protein LI89_14760 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) LI89_14765 ENOG4105X3C heme exporter protein LI89_14770 ENOG41060IM Heme exporter protein LI89_14780 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) LI89_14790 ENOG4105S64 Formate nitrite transporter LI89_14850 ENOG4105CW0 outer membrane usher protein LI89_14855 ENOG4108AF8 Chaperone LI89_14860 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae LI89_14870 ENOG4108VCD Chaperone LI89_14880 ENOG4105D5K Hemolysin activator protein LI89_15000 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA LI89_15005 ENOG4105NTW Transcriptional regulator LI89_15015 ENOG4105CS2 ec 3.2.1.21 LI89_15020 ENOG4105C5Y PTS System LI89_15025 ENOG4105DDV Transcriptional regulator (LacI family LI89_15030 ENOG4108YYC ycei family LI89_15035 ENOG4105DS1 cytochrome b561 LI89_15060 ENOG4105DHJ ABC, transporter LI89_15085 ENOG4105CUB amino acid LI89_15090 ENOG4105CVE Lytic murein transglycosylase LI89_15105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LI89_15110 ENOG4105E82 cytochrome subunit of dehydrogenase LI89_15120 ENOG4105CS2 ec 3.2.1.21 LI89_15140 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin LI89_15145 ENOG4108VKM cytochrome b561 LI89_15150 ENOG4105CHM Aminotransferase LI89_15160 ENOG41072TH Protein of unknown function (DUF1479) LI89_15165 ENOG4108HRK Histidine kinase LI89_15170 ENOG4105DY9 regulatoR LI89_15175 ENOG4105FCD Major Facilitator LI89_15180 ENOG4105CHC glucokinase (EC 2.7.1.2) LI89_15190 ENOG4105C5Q Transcriptional regulator LI89_15195 ENOG4107RA9 decarboxylase LI89_15200 ENOG4105CPC Aldo Keto reductase LI89_15210 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LI89_15215 ENOG4105D9N nucleoside LI89_15240 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) LI89_15270 ENOG4105VRT cytoplasmic protein LI89_15275 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) LI89_15290 ENOG4105C6T cysteine synthase LI89_15295 ENOG4105KZ7 phosphocarrier protein hpr LI89_15300 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) LI89_15305 ENOG4105C5Y PTS System LI89_15310 ENOG4105E0F Histidine kinase LI89_15315 ENOG4105E3W Two component transcriptional regulator (Winged helix family LI89_15320 ENOG4105DJY efflux transporter, rnd family, mfp subunit LI89_15330 ENOG4105C6T cysteine synthase LI89_15340 ENOG4105ECW sulfate abc transporter LI89_15345 ENOG4108I5D sulfate abc transporter LI89_15350 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein LI89_15360 ENOG4105QEK Transcriptional regulator LI89_15365 ENOG4108R66 Conserved Protein LI89_15385 ENOG4105EZR dyp-type peroxidase family protein LI89_15390 ENOG4105E7K (LipO)protein LI89_15400 ENOG4105H4F exported protein LI89_15410 ENOG4108R6G acetyltransferase LI89_15415 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) LI89_15420 ENOG4108UPT UPF0178 protein LI89_15435 ENOG4105C6K Malic enzyme LI89_15445 ENOG4107VIJ nudix hydrolase LI89_15450 ENOG4105CUW cytochrome C-TYPE protein LI89_15455 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) LI89_15460 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LI89_15465 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase LI89_15475 ENOG4105WH1 Two component transcriptional regulator luxr family LI89_15485 ENOG4105BZS acriflavin resistance protein LI89_15685 ENOG4105KUZ arsenate reductase LI89_15690 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) LI89_15700 ENOG4105XYK UPF0370 protein LI89_15705 ENOG4106KED esterase YpfH LI89_15710 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) LI89_15715 ENOG4108VMM UPF0756 membrane protein LI89_15720 ENOG4105CGZ zinc metallopeptidase LI89_15725 ENOG4105C8V SAICAR synthetase LI89_15730 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) LI89_15735 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LI89_15740 ENOG4105RH4 Glycine cleavage system transcriptional repressor LI89_15745 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LI89_15750 ENOG4105C02 permease LI89_15755 ENOG4105ERG peptidase m48, ste24p LI89_15760 ENOG4105K89 arsenate reductase LI89_15765 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) LI89_15770 ENOG4105C2W permease LI89_15775 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) LI89_15780 ENOG4105CXB phosphoribosylaminoimidazole synthetase LI89_15785 ENOG4108V3E phosphoribosylglycinamide formyltransferase LI89_15790 ENOG4108MK9 spermidine N(1)-acetyltransferase LI89_15810 ENOG4105E2Z phosphate ABC transporter (Permease LI89_15815 ENOG4105C8U phosphate abc transporter LI89_15820 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) LI89_15825 ENOG4105C9X ppx gppa phosphatase LI89_15835 ENOG4105CJW magnesium transporter LI89_15840 ENOG4105BZU Histidine kinase LI89_15845 ENOG4105R8A Heat shock protein LI89_15850 ENOG4105ENT Efflux transporter rnd family, mfp subunit LI89_15860 ENOG4105BZS acriflavin resistance protein LI89_15870 ENOG4105C0R drug resistance transporter emrb qaca subfamily LI89_15875 ENOG4105EB3 Histidine kinase LI89_15880 ENOG4105E3W Two component transcriptional regulator (Winged helix family LI89_15885 ENOG4105KWI UPF0339 protein LI89_15900 ENOG4105CFP Peptidase U32 LI89_15905 ENOG4107TE5 Lipid kinase LI89_15910 ENOG410787A Pts system, glucitol sorbitol-specific LI89_15915 ENOG4105DZY Pts system, glucitol sorbitol-specific LI89_15920 ENOG4105VI0 Pts system, glucitol sorbitol-specific LI89_15925 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase LI89_15930 ENOG4105J92 DNA-binding transcriptional activator GutM LI89_15935 ENOG410804X Transcriptional regulator LI89_15945 ENOG4108ZGU inhibitor of vertebrate lysozyme LI89_15955 ENOG4105DWF phosphomethylpyrimidine kinase LI89_15990 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LI89_15995 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LI89_16000 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LI89_16005 ENOG4105VPD cellular component movement LI89_16015 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) LI89_16025 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) LI89_16030 ENOG4105N21 Membrane LI89_16035 ENOG4105CUT histidyl-tRNA synthetase LI89_16040 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) LI89_16045 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) LI89_16055 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs LI89_16065 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) LI89_16075 ENOG4108JQB penicillin-binding protein 1C LI89_16080 ENOG4105DN3 alpha-2-macroglobulin domain protein LI89_16085 ENOG4108MGN ATP-binding component of a transport system LI89_16090 ENOG4108MGN ATP-binding component of a transport system LI89_16095 ENOG4105YYA enhanced serine sensitivity protein SseB LI89_16105 ENOG4105WVQ Fe-S assembly protein IscX LI89_16110 ENOG4108ZIT Ferredoxin, 2FE-2S LI89_16115 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB LI89_16120 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) LI89_16125 ENOG4108Z4V iron-sulfur cluster assembly LI89_16130 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins LI89_16135 ENOG4105C3J Cysteine desulfurase LI89_16140 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family LI89_16145 ENOG4105CVS RNA methyltransferase TrmH family, group 1 LI89_16155 ENOG4105D7X high-affinity nickel-transporter LI89_16160 ENOG41065CD Exported protein LI89_16165 ENOG4108MN2 Stationary phase inducible protein CsiE LI89_16170 ENOG4105D8G Major Facilitator superfamily LI89_16175 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) LI89_16180 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) LI89_16185 ENOG4108M21 LI89_16190 ENOG4105RMW regulation of transcription, DNA-dependent LI89_16195 ENOG4108626 Racemase LI89_16200 ENOG41080QX K07048 phosphotriesterase-related protein LI89_16205 ENOG4105MUZ Protein of unknown function DUF2620 LI89_16210 ENOG4106M0N transport system permease protein LI89_16215 ENOG4108YZA Nitrogen regulatory protein pii LI89_16220 ENOG4105C4K Nad synthetase LI89_16225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LI89_16230 ENOG4108SKK alpha helix protein LI89_16235 ENOG4107WP9 Histidine kinase LI89_16250 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) LI89_16255 ENOG4108Z6B deaminase LI89_16265 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB LI89_16275 ENOG4106G6Q Transcriptional regulator LI89_16280 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding LI89_16285 ENOG4107EFN gluconate transport system permease 3 LI89_16290 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) LI89_16295 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) LI89_16300 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) LI89_16305 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) LI89_16310 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) LI89_16315 ENOG4105C3F Signal peptidase i LI89_16320 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) LI89_16330 ENOG4105WMJ Positive regulator of sigma E, RseC MucC LI89_16340 ENOG41069PW sigma-e factor negative regulatory protein LI89_16355 ENOG4108IYU L-aspartate oxidase LI89_16360 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) LI89_16365 ENOG4105C1J atp-dependent rna helicase LI89_16380 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) LI89_16385 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) LI89_16390 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ LI89_16395 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LI89_16400 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) LI89_16405 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) LI89_16415 ENOG4108Z1B Cyclase dehydrase LI89_16420 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) LI89_16425 ENOG4105DFP Integrase LI89_16495 ENOG4105F9F transposase LI89_16505 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein LI89_16525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LI89_16545 ENOG4105CPQ Dehydrogenase LI89_16550 ENOG41085W3 Transposase LI89_16570 ENOG4105F9F transposase LI89_16625 ENOG4105CHH sulfate transporter LI89_16630 ENOG410901P UPF0249 protein LI89_16635 ENOG4105EZV Transcriptional regulator LI89_16640 ENOG4105VCP PTS System LI89_16645 ENOG4105CS2 ec 3.2.1.21 LI89_16650 ENOG4105CK1 PTS System LI89_16655 ENOG4105VZJ PTS System LI89_16660 ENOG4105D8V Glucose sorbosone dehydrogenase LI89_16670 ENOG41086WQ Protein CrcB homolog LI89_16675 ENOG4107SVH Potassium channel protein LI89_16680 ENOG4105XXV Acid-resistance protein LI89_16695 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) LI89_16700 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) LI89_16705 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) LI89_16710 ENOG4108VDS Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) LI89_16715 ENOG4105CQM Urea amidohydrolase subunit alpha LI89_16740 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) LI89_16745 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) LI89_16750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LI89_16785 ENOG4105VEQ Cold shock protein LI89_16795 ENOG4108SAJ Protein of unknown function (DUF1198) LI89_16800 ENOG4108WMJ Protein of unknown function (DUF2002) LI89_16810 ENOG41075H3 AraC family transcriptional regulator LI89_16830 ENOG4105TNS Conserved Protein LI89_16840 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) LI89_16845 ENOG4105WAZ (Glutaredoxin-like protein) NrdH LI89_16850 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) LI89_16860 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LI89_16865 ENOG4108IJ7 Glycine betaine LI89_16870 ENOG4108HQS Glycine betaine LI89_16875 ENOG4105GIJ Glycine betaine LI89_16885 ENOG4108JDX DNA polymerase iii, epsilon subunit LI89_16890 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LI89_16895 ENOG4105D1A Methyltransferase LI89_16900 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) LI89_16905 ENOG4105E9H Lytic Murein transglycosylase LI89_16910 ENOG4107NA1 Endonuclease Exonuclease phosphatase LI89_16915 ENOG4105F27 Major Facilitator LI89_16920 ENOG4105HEI LysR family (Transcriptional regulator LI89_16925 ENOG4105CV8 reductase LI89_16930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LI89_16935 ENOG4105C2D reductase LI89_16945 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LI89_16975 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LI89_17045 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase LI89_17055 ENOG4108UMI ABC transporter, permease LI89_17060 ENOG4105D01 (LipO)protein LI89_17065 ENOG4108R8X outer membrane lipoprotein LI89_17070 ENOG4108R96 Methyltransferase, YaeB family LI89_17080 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) LI89_17085 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion LI89_17090 ENOG4108YZN class I peptide chain release factor LI89_17095 ENOG4108VWS Yaeq family LI89_17100 ENOG4105W1I UPF0253 protein LI89_17105 ENOG4105M1T rho-binding antiterminator LI89_17110 ENOG4105N7H Cytochrome LI89_17115 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) LI89_17120 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase LI89_17125 ENOG4105CXN decarboxylase LI89_17130 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) LI89_17135 ENOG4105C0B DNA polymerase III (alpha subunit) LI89_17140 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LI89_17145 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LI89_17150 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LI89_17155 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LI89_17160 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LI89_17165 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) LI89_17175 ENOG4105DZP Membrane-associated zinc metalloprotease LI89_17180 ENOG4105KNE Phosphatidate cytidylyltransferase LI89_17185 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) LI89_17190 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) LI89_17195 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) LI89_17200 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) LI89_17205 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) LI89_17210 ENOG4105CE9 30S ribosomal protein S2 LI89_17220 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LI89_17225 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) LI89_17230 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) LI89_17235 ENOG4108T8E UPF0325 protein LI89_17240 ENOG4105QDK Flavodoxin LI89_17245 ENOG4105DR9 pseudouridine synthase LI89_17250 ENOG4105WP7 tRNA pseudouridine synthase C LI89_17260 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) LI89_17265 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) LI89_17270 ENOG4105EWT decarboxylase family LI89_17275 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease LI89_17280 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) LI89_17285 ENOG4105M08 Membrane LI89_17290 ENOG4105ETT transcriptional Regulator, LysR family LI89_17295 ENOG4105M5B (LipO)protein LI89_17300 ENOG4105C9B Cysteine desulfurase LI89_17305 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) LI89_17310 ENOG4105CUZ uba thif-type nad fad binding protein LI89_17315 ENOG4105CA3 membrane-bound lytic murein transglycosylase LI89_17335 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LI89_17340 ENOG4107QZM n-acetylglutamate synthase LI89_17345 ENOG4107QYX exodeoxyribonuclease v alpha LI89_17350 ENOG4107QKA exodeoxyribonuclease V beta LI89_17355 ENOG4107QXK peptidase LI89_17360 ENOG4105DSY exodeoxyribonuclease V, gamma LI89_17385 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) LI89_17390 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) LI89_17395 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase LI89_17400 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) LI89_17410 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) LI89_17415 ENOG4105EE5 Membrane protein terC LI89_17420 ENOG4105CPC Aldo Keto reductase LI89_17425 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) LI89_17430 ENOG4105CEY Amp-dependent synthetase and ligase LI89_17440 ENOG41060NJ transcriptional regulator LI89_17445 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LI89_17450 ENOG4105RQF LysR family Transcriptional regulator LI89_17455 ENOG4105F27 Major Facilitator LI89_17460 ENOG4105EJC lysr family transcriptional regulator LI89_17475 ENOG4105C8Q Methyl-accepting chemotaxis LI89_17495 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) LI89_17525 ENOG4108VAU general secretion pathway protein G LI89_17530 ENOG4105D7Q type ii secretion system LI89_17535 ENOG4107QHF type ii secretion system protein e LI89_17555 ENOG4107B2H carbonic anhydrase LI89_17560 ENOG4105KVH Transcriptional regulator LI89_17565 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr LI89_17575 ENOG4105DVC DnaJ domain protein LI89_17585 ENOG4105DPW Major facilitator superfamily MFS_1 LI89_17600 ENOG4105F7P transcriptional regulator AsnC family LI89_17605 ENOG4105BZU Histidine kinase LI89_17610 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein LI89_17755 ENOG4105DFP Integrase LI89_17765 ENOG4105CRK lysyL-tRNA synthetase LI89_17770 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) LI89_17775 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) LI89_17780 ENOG4105T95 Thiol disulfide interChange protein LI89_17785 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LI89_17790 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) LI89_17795 ENOG4105CT7 inner membrane cred family protein LI89_17800 ENOG4105EB3 Histidine kinase LI89_17805 ENOG4105E3W Two component transcriptional regulator (Winged helix family LI89_17815 ENOG4105Y75 tpr repeat protein LI89_17820 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) LI89_17825 ENOG4108UT2 hemolysin iii LI89_17835 ENOG4105CYX Short-chain dehydrogenase reductase Sdr LI89_17845 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor LI89_17855 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) LI89_17860 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) LI89_17865 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family LI89_17870 ENOG4105D0A hydroxylase LI89_17875 ENOG4107RAQ aminopeptidase LI89_17880 ENOG4105E07 UPF0149 protein LI89_17885 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) LI89_17890 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase LI89_17895 ENOG4108JQ1 Dehydrogenase LI89_17900 ENOG4105E66 phosphoriboisomerase A LI89_17905 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) LI89_17910 ENOG4105MPN Membrane LI89_17915 ENOG4108ZUB Lysine exporter protein (Lyse ygga) LI89_17920 ENOG4105D64 Mechanosensitive ion channel LI89_17925 ENOG4105D2N Aldolase LI89_17930 ENOG4105BZA Phosphoglycerate kinase LI89_17935 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LI89_17940 ENOG4105CV1 Transketolase (EC 2.2.1.1) LI89_17945 ENOG4108K0D peptidase, M48 LI89_17955 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) LI89_17965 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP LI89_17980 ENOG41080HT Transcriptional regulator, arsr family LI89_17985 ENOG4105GPY SprT protein LI89_17990 ENOG4105RWS endonuclease I LI89_17995 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) LI89_18000 ENOG4105D7Z glutathione synthase LI89_18005 ENOG4108UJU UPF0301 protein LI89_18010 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) LI89_18015 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) LI89_18025 ENOG4105CZX twitching motility protein LI89_18030 ENOG4105DFA alanine racemase domain protein LI89_18035 ENOG4105II7 pyrroline-5-carboxylate reductase LI89_18040 ENOG4108VIA integral membrane protein LI89_18045 ENOG4105VZ9 UPF0235 protein LI89_18050 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LI89_18055 ENOG4105CSA Coproporphyrinogen iii oxidase LI89_18060 ENOG4105K33 Periplasmic Protein LI89_18065 ENOG4105CSV Glutaminase LI89_18070 ENOG41090ED Protein with unknown function (DUF469) LI89_18075 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) LI89_18080 ENOG4105CEN a g-specific adenine glycosylase LI89_18085 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) LI89_18090 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division LI89_18100 ENOG4105CXN decarboxylase LI89_18115 ENOG4107EXC regulatoR LI89_18125 ENOG4105JJR Histidine kinase LI89_18130 ENOG4108T94 DNA-binding transcriptional activator BglJ LI89_18150 ENOG4105D5Q Arginine ornithine antiporter LI89_18155 ENOG4105CXN decarboxylase LI89_18165 ENOG4108MI0 Resistance protein LI89_18170 ENOG4105J12 Multidrug resistance protein mdtN LI89_18190 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LI89_18195 ENOG4108IPW abc transporter atp-binding protein LI89_18200 ENOG4105CM4 permease protein LI89_18225 ENOG4105T38 integral membrane protein LI89_18230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LI89_18245 ENOG4105ETE Transcriptional regulator (LacI family LI89_18255 ENOG4105EAM Na Pi-cotransporter LI89_18270 ENOG4105CSH Transporter LI89_18280 ENOG4108Q9V regulatoR LI89_18310 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase LI89_18315 ENOG4105C8H hydrogenase maturation protein Hypf LI89_18320 ENOG4105C45 hydrogenase expression formation protein (HypE) LI89_18325 ENOG4105CQS hydrogenase expression formation protein HypD LI89_18330 ENOG41082MF Hydrogenase assembly chaperone hypC hupF LI89_18335 ENOG4107RSS Hydrogenase accessory protein HypB LI89_18340 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) LI89_18345 ENOG4108WGS hydrogenase 2-specific chaperone LI89_18350 ENOG4108USZ hydrogenase LI89_18355 ENOG4105DPX Hydrogenase, large subunit LI89_18360 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit LI89_18365 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LI89_18370 ENOG4105E3S small subunit LI89_18375 ENOG4108XTF Outer Membrane Lipoprotein LI89_18400 ENOG4105C8Q Methyl-accepting chemotaxis LI89_18405 ENOG4105EXW epimerase dehydratase LI89_18410 ENOG4105CSP Major Facilitator Superfamily LI89_18415 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein LI89_18420 ENOG4105DQ5 transport system permease protein LI89_18425 ENOG4105TVJ transport system, permease LI89_18430 ENOG4105E0A ABC, transporter LI89_18440 ENOG4105E0K tonB-dependent siderophore receptor LI89_18460 ENOG4105EP1 Efflux transporter rnd family, mfp subunit LI89_18465 ENOG4108IJF Heavy metal efflux pump, CzcA LI89_18470 ENOG4105CF1 Alkylated DNA repair protein LI89_18545 ENOG4108ZZF transport protein (ExbD) LI89_18550 ENOG4105CWK Biopolymer transport protein, ExbB LI89_18555 ENOG4105C28 cystathionine LI89_18560 ENOG4108K81 inner membrane protein YghB LI89_18565 ENOG4105CF7 AraC family transcriptional regulator LI89_18570 ENOG4108I6A alcohol dehydrogenase LI89_18575 ENOG4105CV8 reductase LI89_18590 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) LI89_18595 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase LI89_18600 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LI89_18605 ENOG4105NF4 modulator of drug activity LI89_18610 ENOG4105VRH Antibiotic biosynthesis monooxygenase LI89_18615 ENOG4105JQN Transcriptional regulator LI89_18620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LI89_18625 ENOG4105IPS esterase LI89_18630 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) LI89_18635 ENOG4108SX3 cytoplasmic protein LI89_18640 ENOG41087AY ADP-Ribose pyrophosphatase LI89_18645 ENOG4105DFG type I secretion outer membrane protein LI89_18650 ENOG4105F1G UPF0441 protein LI89_18655 ENOG4106032 Glutathionylspermidine synthase LI89_18660 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b LI89_18665 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) LI89_18670 ENOG4105W0Z cytoplasmic protein LI89_18675 ENOG4105DVH amino acid LI89_18680 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) LI89_18685 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) LI89_18690 ENOG4105I7R Adenylate cyclase LI89_18695 ENOG4106MWK domain protein LI89_18700 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate LI89_18705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) LI89_18710 ENOG4107ZVW dihydroneopterin aldolase LI89_18715 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) LI89_18720 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LI89_18725 ENOG4105VCC 30S ribosomal protein S21 LI89_18730 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) LI89_18735 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LI89_18750 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures LI89_18755 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles LI89_18760 ENOG4108XS9 dna repair protein LI89_18765 ENOG4105MFG Antirestriction protein LI89_18770 ENOG4106ZN7 UPF0401 protein YkfF LI89_18785 ENOG4108KZE transcriptional regulator LI89_18790 ENOG4106H6R UPF0380 protein LI89_18795 ENOG4108MXD gtp-binding protein LI89_18815 ENOG4105D0M Protease HtpX homolog LI89_18860 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) LI89_18870 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LI89_18875 ENOG4105VN1 Heat shock protein LI89_18905 ENOG4105MP0 transposase LI89_18915 ENOG4105JXR Protein of unknown function (DUF3296) LI89_18920 ENOG4108P8R LI89_18940 ENOG4105MZU cell filamentation protein LI89_18950 ENOG4105EHZ conserved protein UCP016719 LI89_18960 ENOG4105D17 glycoside hydrolase, family 3 domain protein LI89_18965 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) LI89_18970 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate LI89_18975 ENOG4105C5Y PTS System LI89_18980 ENOG4105CSV Glutaminase LI89_18985 ENOG4105E5D amino acid LI89_18990 ENOG4105CVK Glutamate decarboxylase LI89_19005 ENOG4108YK4 Acid-resistance membrane protein LI89_19010 ENOG4108594 Permease of the drug metabolite transporter LI89_19015 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LI89_19020 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) LI89_19030 ENOG4108VKG metal-dependent hydrolase LI89_19035 ENOG4105EE0 oxidoreductase LI89_19040 ENOG4105DU1 integral membrane protein, terc LI89_19045 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) LI89_19050 ENOG4105P66 Membrane LI89_19055 ENOG4105CTX dehydratase LI89_19060 ENOG4107QZW Altronate oxidoreductase LI89_19065 ENOG4105D2H Uronic isomerase LI89_19070 ENOG4105DPW Major facilitator superfamily MFS_1 LI89_19085 ENOG4106W5V Membrane LI89_19100 ENOG4105NE1 Conserved Protein LI89_19105 ENOG41090KG Inner membrane protein YqjE LI89_19110 ENOG4105YJD LI89_19115 ENOG4108VBZ doxx family LI89_19120 ENOG4105CHF Glutathione S-transferase LI89_19125 ENOG4105CWB LysR family transcriptional Regulator LI89_19130 ENOG4108CNN domain protein LI89_19135 ENOG4105DQ4 alcohol dehydrogenase LI89_19140 ENOG4107SET aldo keto reductase LI89_19145 ENOG4105EQ2 LysR family Transcriptional regulator LI89_19170 ENOG4108C33 Resolvase LI89_19205 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) LI89_19215 ENOG41082RQ UPF0102 protein LI89_19220 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) LI89_19225 ENOG4105W4M Transport-associated protein LI89_19230 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase LI89_19235 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain LI89_19240 ENOG4105BZU Histidine kinase LI89_19245 ENOG4105N5T Radical SAM Protein LI89_19250 ENOG4105CBC glutamate synthase LI89_19255 ENOG4105BZ8 glutamate synthase LI89_19265 ENOG4105KB2 stringent starvation protein b LI89_19270 ENOG4107MKT Stringent starvation protein a LI89_19280 ENOG4108UJD 30S ribosomal protein S9 LI89_19285 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) LI89_19290 ENOG4105D6Z AFG1 family ATPase LI89_19295 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III LI89_19300 ENOG4105C0H protease LI89_19305 ENOG4105C0H protease LI89_19310 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LI89_19315 ENOG4105VFK BolA family LI89_19320 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane LI89_19325 ENOG4105E3I toluene tolerance LI89_19330 ENOG4107PE3 Mammalian cell entry related domain protein LI89_19335 ENOG4105CY3 ABC transporter, permease LI89_19340 ENOG4105DHJ ABC, transporter LI89_19345 ENOG4105FEU K -dependent Na -Ca exchanger LI89_19350 ENOG4105C2X Arabinose 5-phosphate isomerase LI89_19355 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase LI89_19360 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) LI89_19365 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA LI89_19370 ENOG4108IUZ ABC transporter LI89_19375 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LI89_19380 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA LI89_19385 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN LI89_19390 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) LI89_19395 ENOG41080Z8 PHOSPHOCARRIER protein LI89_19405 ENOG4105CXT aspartate transcarbamylase LI89_19410 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) LI89_19415 ENOG4105KME endoribonuclease L-psp LI89_19450 ENOG4105CG3 alpha amylase, catalytic region LI89_19455 ENOG4105C5Y PTS System LI89_19460 ENOG4105D4X repressor LI89_19465 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic LI89_19475 ENOG41084S7 Plasmid maintenance system antidote protein LI89_19480 ENOG4105EMD TRANSCRIPTIONal LI89_19500 ENOG41069H0 dihydroorotase EC 3.5.2.3 LI89_19530 ENOG4105NXH GreA GreB family elongation factor LI89_19535 ENOG4108XVM Cytochrome b(562) LI89_19540 ENOG4105CMS peptidase U62, modulator of DNA gyrase LI89_19545 ENOG4105N42 UPF0307 protein LI89_19550 ENOG4105UNR (Barnase) inhibitor LI89_19565 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) LI89_19570 ENOG4105Y49 secretion protein, HlyD family LI89_19575 ENOG4105ZQC membrane protein AaeX LI89_19580 ENOG4105CR8 Transcriptional regulator LI89_19625 ENOG4105D1U peptidase U62 modulator of DNA gyrase LI89_19635 ENOG4105QD6 exported protein LI89_19640 ENOG4105C03 ribonuclease LI89_19650 ENOG4105VQ7 Rod shape-determining protein MreD LI89_19655 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) LI89_19660 ENOG4105DFF Rod shape-determining protein mreb LI89_19665 ENOG41062P1 Diguanylate cyclase phosphodiesterase LI89_19670 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family LI89_19680 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) LI89_19685 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) LI89_19690 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein LI89_19695 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LI89_19700 ENOG4105RG0 Membrane LI89_19705 ENOG4108IA2 Sodium pantothenate symporter LI89_19710 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) LI89_19715 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LI89_19720 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) LI89_19735 ENOG4105CAR Terminase, large subunit LI89_19835 ENOG4105DFP Integrase LI89_19840 ENOG4105BZU Histidine kinase LI89_19845 ENOG4108XTF Outer Membrane Lipoprotein LI89_19850 ENOG4105VEQ Cold shock protein LI89_19855 ENOG4105VEQ Cold shock protein LI89_19860 ENOG4105VEQ Cold shock protein LI89_19865 ENOG4107QPK )-transporter LI89_19870 ENOG4105D1S lipid A biosynthesis LI89_19885 ENOG4105EZ7 amino acid ABC transporter LI89_19890 ENOG4105DRP amino acid AbC transporter LI89_19895 ENOG4105CDA abc transporter atp-binding protein LI89_19910 ENOG4105CMU LysR family (Transcriptional regulator LI89_19915 ENOG4105EEQ Na H antiporter LI89_19920 ENOG4105C7N Xanthine uracil vitamin C permease LI89_19935 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LI89_19940 ENOG4105MSB protein, conserved in bacteria LI89_19945 ENOG4105CGF Aromatic amino acid aminotransferase LI89_19950 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LI89_19955 ENOG4105CDU Replicative dna helicase LI89_19960 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein LI89_19970 ENOG4105P4Z Phage shock protein G LI89_19975 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LI89_19980 ENOG4105MYN Zinc uptake regulation protein LI89_19985 ENOG4105VDW Csbd family LI89_19990 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) LI89_19995 ENOG41080IJ Diacylglycerol kinase LI89_20000 ENOG4105E55 glycerol-3-phosphate acyltransferase LI89_20005 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) LI89_20010 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) LI89_20015 ENOG4107W52 maltose operon periplasmic protein LI89_20020 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) LI89_20030 ENOG4107FKK extracellular solute-binding protein family 1 LI89_20035 ENOG4105D56 permease protein LI89_20040 ENOG4105EG2 ABC transporter, permease LI89_20045 ENOG4108VY7 phosphate-starvation-inducible protein PsiE LI89_20050 ENOG4107QP8 phosphohexose isomerase LI89_20055 ENOG4105CFH Aspartokinase LI89_20060 ENOG4105C09 Bile acid LI89_20075 ENOG4105C3R Methionine synthase LI89_20080 ENOG41069M3 Transcriptional regulator LI89_20085 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) LI89_20090 ENOG4108I9X Isocitrate lyase LI89_20095 ENOG4107QP3 malate synthase g LI89_20100 ENOG4105CVG Homoserine O-transsuccinylase LI89_20130 ENOG4108Z0R Transferase LI89_20135 ENOG4105E2X shikimate dehydrogenase LI89_20140 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LI89_20145 ENOG4108WI1 Dna topoisomerase LI89_20155 ENOG4105C79 DNA protecting protein DprA LI89_20160 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) LI89_20165 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) LI89_20170 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LI89_20175 ENOG4105C1A potassium transporter peripheral membrane LI89_20180 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) LI89_20185 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system LI89_20190 ENOG4105W1Y Transcriptional regulator LI89_20195 ENOG4105VTS DnaJ-like, subfamily C LI89_20200 ENOG4108ZT0 50S ribosomal protein l17 LI89_20205 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LI89_20210 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) LI89_20215 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) LI89_20220 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits LI89_20225 ENOG41067V7 50S ribosomal protein L36 LI89_20230 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) LI89_20235 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) LI89_20240 ENOG4105VPB 50S ribosomal protein L30 LI89_20250 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) LI89_20255 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) LI89_20265 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LI89_20270 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits LI89_20275 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) LI89_20285 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal LI89_20290 ENOG41083MP 50s ribosomal protein l29 LI89_20295 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) LI89_20300 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) LI89_20305 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) LI89_20310 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) LI89_20315 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity LI89_20320 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) LI89_20325 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) LI89_20330 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) LI89_20350 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LI89_20360 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) LI89_20370 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) LI89_20375 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) LI89_20380 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) LI89_20385 ENOG4105WWK YheO domain protein LI89_20390 ENOG4108V1T peptidylprolyl cis-trans isomerase LI89_20400 ENOG4108YZY peptidylprolyl cis-trans isomerase LI89_20405 ENOG4105VKU nucleicacid-binding protein LI89_20415 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein LI89_20420 ENOG4105C5H ABC transporter LI89_20425 ENOG4105K64 Glycosyl transferase, family 2 LI89_20435 ENOG4105E2B Taurine dioxygenase LI89_20440 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component LI89_20450 ENOG4106FTQ Taurine ABC transporter, periplasmic LI89_20455 ENOG4105JAB phenazine biosynthesis protein, phzf family LI89_20465 ENOG4105DNZ Alpha Beta Hydrolase LI89_20470 ENOG4105YP7 UPF0270 protein LI89_20475 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) LI89_20480 ENOG4108UKZ OsmC family LI89_20490 ENOG410613R integral membrane protein, YccS YhfK family LI89_20495 ENOG4105C8Y Acetylornithine aminotransferase LI89_20505 ENOG4105D7A ATP-binding protein LI89_20510 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) LI89_20515 ENOG4105F8D glycoside hydrolase family 4 LI89_20520 ENOG41060NJ transcriptional regulator LI89_20525 ENOG4106DTQ Protein TsgA homolog LI89_20530 ENOG4105DZC cytosine deaminase LI89_20535 ENOG4107QZF nitrite reductase NADPH large subunit LI89_20540 ENOG4105WZK nitrite reductase NADPH small subunit LI89_20545 ENOG4107V9H nitrite transporter LI89_20550 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LI89_20555 ENOG4105C31 Tryptophanyl-tRNA synthetase LI89_20565 ENOG4105DJV ribulose-phosphate 3-epimerase LI89_20585 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) LI89_20590 ENOG4105E4G Type IV pilus LI89_20615 ENOG4108JQC penicillin-binding protein 1A LI89_20620 ENOG4107RK2 ADP-ribose diphosphatase NudE LI89_20625 ENOG4105DQY intracellular growth attenuator LI89_20630 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 LI89_20635 ENOG4105VEJ Heat shock protein LI89_20645 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase LI89_20650 ENOG4105E0F Histidine kinase LI89_20655 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LI89_20660 ENOG4108RRZ Transcription elongation factor GreB LI89_20665 ENOG4105BZM domain protein LI89_20670 ENOG4105XFK Ferrous iron transport protein A LI89_20675 ENOG4105CE1 Ferrous iron transport protein b LI89_20680 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) LI89_20685 ENOG4105RID UPF0379 protein yhcN LI89_20690 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) LI89_20695 ENOG4105MJ2 Competence protein LI89_20700 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) LI89_20705 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) LI89_20710 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) LI89_20715 ENOG41061ZR Transcriptional regulator LI89_20730 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) LI89_20735 ENOG4105E98 transcriptional regulator DeoR family LI89_20745 ENOG4105C6V Glycerol-3-phosphate dehydrogenase LI89_20750 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) LI89_20755 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) LI89_20765 ENOG4108IUM Glycogen debranching enzyme LI89_20770 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) LI89_20775 ENOG4108HRK Histidine kinase LI89_20790 ENOG4105C7K acetolactate synthase LI89_20795 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LI89_20800 ENOG41076UM multiple antibiotic resistance (MarC)-related protein LI89_20805 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family LI89_20810 ENOG4105C6Z Gluconate LI89_20815 ENOG4105DIQ Transcriptional regulator LI89_20820 ENOG4105C2I pirin domain protein LI89_20825 ENOG4105WCN acetyltransferase LI89_20830 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) LI89_20835 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) LI89_20845 ENOG4105D7K pfkb domain protein LI89_20855 ENOG4105DH8 myo-inositol catabolism LI89_20860 ENOG4105C26 Dehydrogenase LI89_20870 ENOG4105EQ0 Major Facilitator superfamily LI89_20875 ENOG4105CR8 Transcriptional regulator LI89_20885 ENOG4108HCJ Hydrolase LI89_20890 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase LI89_20895 ENOG4107GFK fumarate LI89_20900 ENOG41090KR LysR family transcriptional Regulator LI89_20910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LI89_20915 ENOG4105JZC GHMP kinase LI89_20920 ENOG4107WFU Glutamate mutase subunit sigma LI89_20930 ENOG4105DJI Methylaspartate mutase, E subunit LI89_20950 ENOG4105CK2 sodium dicarboxylate symporter LI89_20955 ENOG4105CBX hi0933 family LI89_20960 ENOG4105CJ3 phosphate transporter LI89_20965 ENOG4108V6B universal stress protein B LI89_20970 ENOG4108M6U Universal stress protein A LI89_20985 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) LI89_20990 ENOG4105DGW oligopeptidase A LI89_20995 ENOG4105D6S protein involved in catabolism of external DNA LI89_21000 ENOG4105DC8 reductase LI89_21050 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 LI89_21065 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase LI89_21120 ENOG4107H3J ribonuclease LI89_21125 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) LI89_21130 ENOG41066T0 asmA family LI89_21135 ENOG4105CMB EAL domain-containing protein LI89_21140 ENOG4105VSH 4-oxalocrotonate tautomerase LI89_21145 ENOG4107SS6 2-dehydro-3-deoxygluconokinase LI89_21150 ENOG4105CS0 peptidase LI89_21155 ENOG4105CK2 sodium dicarboxylate symporter LI89_21170 ENOG4108PU9 oligogalacturonate-specific porin LI89_21175 ENOG4105BZU Histidine kinase LI89_21180 ENOG4105EJG cellulose synthase LI89_21185 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) LI89_21190 ENOG4107EEX Cellulose synthase regulator protein LI89_21195 ENOG4107QZ7 Cellulose synthase catalytic subunit LI89_21205 ENOG4105UTS cellulose synthase operon protein YhjQ LI89_21215 ENOG4105U74 cellulose biosynthesis protein BcsE LI89_21220 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT LI89_21225 ENOG4105D1V cellulose synthase operon protein YhjU LI89_21230 ENOG4108JQ7 (ABC) transporter LI89_21235 ENOG4105C3U ABC transporter LI89_21240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LI89_21245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LI89_21250 ENOG4105DEF Extracellular solute-binding protein, family 5 LI89_21255 ENOG4105CKT filamentous hemagglutinin LI89_21260 ENOG4105D5K Hemolysin activator protein LI89_21265 ENOG4105CKT filamentous hemagglutinin LI89_21275 ENOG4105CXY transporter LI89_21280 ENOG4105BZU Histidine kinase LI89_21285 ENOG4108KX4 response regulator LI89_21290 ENOG4105DIJ Phosphoethanolamine transferase LI89_21295 ENOG4108ZHJ Organic hydroperoxide resistance protein LI89_21305 ENOG4105C85 amino acid LI89_21310 ENOG4105C84 Histidine ammonia-lyase LI89_21315 ENOG4105CGP Urocanate hydratase LI89_21330 ENOG4105CW0 outer membrane usher protein LI89_21355 ENOG4105EIP mannose-6-phosphate isomerase LI89_21360 ENOG4105CS2 ec 3.2.1.21 LI89_21375 ENOG4105CK1 PTS System LI89_21380 ENOG4105VZJ PTS System LI89_21385 ENOG4105CK1 PTS System LI89_21390 ENOG4105VCP PTS System LI89_21395 ENOG4105DKQ ROK family LI89_21400 ENOG41060NJ transcriptional regulator LI89_21455 ENOG4105DFP Integrase LI89_21460 ENOG4105T16 Transcriptional regulator (AraC family) LI89_21465 ENOG4107RNG ABC transporter LI89_21475 ENOG4105DFW ABC transporter LI89_21480 ENOG4105C93 Xylose Isomerase LI89_21485 ENOG4105CMG Carbohydrate kinase LI89_21490 ENOG4108TTM chaperone LI89_21510 ENOG4105MEV Acyl-transferase LI89_21520 ENOG4105EM7 Selenocysteine-specific translation elongation factor LI89_21525 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) LI89_21530 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) LI89_21535 ENOG4108MG3 formate dehydrogenase LI89_21540 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LI89_21545 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LI89_21550 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LI89_21555 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) LI89_21560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) LI89_21565 ENOG4105C8Q Methyl-accepting chemotaxis LI89_21570 ENOG4108RPX mosc domain containing protein LI89_21575 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A LI89_21585 ENOG4108YYI Protein of unknown function (DUF2810) LI89_21590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LI89_21600 ENOG4105E61 Mannitol repressor protein LI89_21605 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase LI89_21610 ENOG4105CTS PTS system mannitol-specific LI89_21615 ENOG4106JH6 (LipO)protein LI89_21620 ENOG4105C38 Glycyl-tRNA synthetase beta subunit LI89_21625 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit LI89_21630 ENOG4108R3E Dna-3-methyladenine glycosylase i LI89_21650 ENOG4108ZG0 Ompa motb domain protein LI89_21665 ENOG4105C5I Dehydrogenase LI89_21670 ENOG4107T9C Alpha amylase catalytic region LI89_21675 ENOG4105JKW Valine--pyruvate aminotransferase LI89_21680 ENOG4105D0C transport protein LI89_21695 ENOG4105R2A (LipO)protein LI89_21700 ENOG4105D99 atp gtp-binding protein LI89_21705 ENOG4105C7B Threonine dehydratase LI89_21715 ENOG41066F8 ROK family LI89_21720 ENOG410667J hydrolase LI89_21725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LI89_21730 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) LI89_21735 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) LI89_21740 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) LI89_21745 ENOG4105VG0 50S ribosomal protein l34 LI89_21750 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) LI89_21755 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins LI89_21760 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) LI89_21765 ENOG4105RKW reductase (By LI89_21780 ENOG4108UMI ABC transporter, permease LI89_21785 ENOG4105C8Q Methyl-accepting chemotaxis LI89_21790 ENOG4108YYH Nadph-dependent fmn reductase LI89_21795 ENOG4105BZU Histidine kinase LI89_21810 ENOG4105C7N Xanthine uracil vitamin C permease LI89_21815 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 LI89_21820 ENOG4105DRP amino acid AbC transporter LI89_21825 ENOG4105EAD ABC transporter LI89_21830 ENOG4106PMH Extracellular solute-binding protein family 3 LI89_21850 ENOG4105E2Z phosphate ABC transporter (Permease LI89_21855 ENOG4105C8U phosphate abc transporter LI89_21860 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) LI89_21865 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) LI89_21870 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) LI89_21875 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) LI89_21880 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) LI89_21885 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) LI89_21890 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) LI89_21895 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LI89_21900 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LI89_21905 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LI89_21910 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) LI89_21915 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation LI89_21920 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) LI89_21925 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) LI89_21975 ENOG4105EQR Transposase IS116 IS110 IS902 LI89_22220 ENOG4105D13 transposase LI89_22235 ENOG4105EQR Transposase IS116 IS110 IS902 LI89_22245 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB LI89_22250 ENOG4105ETZ PTS System LI89_22255 ENOG4105F3R pts system mannose fructose sorbose family iid LI89_22280 ENOG4106AM8 polysaccharide lyase family 8 LI89_22425 ENOG4105EQR Transposase IS116 IS110 IS902 LI89_22430 ENOG41085W3 Transposase