locus-tag	class	description
LI89_00005	COG0716	FMN binding
LI89_00010	COG1522	sequence-specific DNA binding
LI89_00015	COG2502	aspartate--ammonia ligase
LI89_00025	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LI89_00030	COG0714	Associated with various cellular activities
LI89_00035	COG3158	transport of potassium into the cell
LI89_00040	COG1869	D-ribose catabolic process
LI89_00050	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_00055	COG1879	ABC-type sugar transport system periplasmic component
LI89_00060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_00065	COG1609	Transcriptional regulator
LI89_00070	COG0477	Major facilitator Superfamily
LI89_00075	COG2186	Transcriptional regulator
LI89_00100	COG1763	Mo-molybdopterin cofactor biosynthetic process
LI89_00110	COG3084	Protein conserved in bacteria
LI89_00115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LI89_00120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LI89_00125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LI89_00125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LI89_00130	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LI89_00135	COG3078	GTPase activator activity
LI89_00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LI89_00150	COG3852	Histidine kinase
LI89_00155	COG0174	glutamine synthetase
LI89_00165	COG1011	Hydrolase
LI89_00170	COG1295	ribonuclease BN
LI89_00175	COG1490	D-aminoacyl-tRNA deacylase activity
LI89_00180	COG0456	acetyltransferase
LI89_00185	COG3423	Transcriptional regulator
LI89_00205	COG2982	Protein involved in outer membrane biogenesis
LI89_00210	COG2233	PERMEase
LI89_00215	COG0786	glutamate:sodium symporter activity
LI89_00220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LI89_00225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI89_00230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LI89_00235	COG1758	RNA polymerase activity
LI89_00245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LI89_00250	COG2860	membrane
LI89_00260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LI89_00265	COG1024	Enoyl-CoA hydratase
LI89_00270	COG5001	Diguanylate cyclase
LI89_00285	COG1561	YicC-like family, N-terminal region
LI89_00290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LI89_00295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LI89_00300	COG1309	transcriptional regulator
LI89_00305	COG0756	dUTP diphosphatase activity
LI89_00310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LI89_00315	COG2003	Belongs to the UPF0758 family
LI89_00320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LI89_00325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LI89_00330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LI89_00335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LI89_00345	COG1519	Transferase
LI89_00350	COG0859	PFAM glycosyl transferase family 9
LI89_00355	COG0859	PFAM glycosyl transferase family 9
LI89_00360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_00365	COG0156	8-amino-7-oxononanoate synthase activity
LI89_00370	COG1063	alcohol dehydrogenase
LI89_00375	COG2861	carbohydrate metabolic process
LI89_00380	COG4942	peptidase
LI89_00385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LI89_00390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI89_00395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_00400	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LI89_00405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LI89_00410	COG1045	serine acetyltransferase
LI89_00415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LI89_00420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LI89_00420	COG2169	Transcriptional regulator
LI89_00425	COG2205	protein histidine kinase activity
LI89_00430	COG0745	RESPONSE REGULATOR receiver
LI89_00435	COG3678	ATP-independent chaperone mediated protein folding
LI89_00440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LI89_00450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LI89_00460	COG0149	triose-phosphate isomerase activity
LI89_00470	COG3152	Membrane
LI89_00480	COG2814	Major facilitator Superfamily
LI89_00485	COG1494	fructose-1,6-bisphosphatase
LI89_00490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI89_00495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LI89_00505	COG3074	FtsZ-dependent cytokinesis
LI89_00510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LI89_00515	COG1575	Belongs to the MenA family. Type 1 subfamily
LI89_00520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LI89_00525	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LI89_00530	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LI89_00535	COG1609	Transcriptional regulator
LI89_00540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LI89_00545	COG0254	rRNA binding
LI89_00550	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LI89_00555	COG0626	cystathionine gamma-synthase activity
LI89_00560	COG0527	aspartate kinase activity
LI89_00560	COG0460	homoserine dehydrogenase
LI89_00570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LI89_00580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LI89_00585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LI89_00590	COG0165	Argininosuccinate lyase
LI89_00595	COG1629	transport
LI89_00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_00640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_00640	COG0678	peroxiredoxin activity
LI89_00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_00655	COG1309	transcriptional regulator
LI89_00665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_00675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LI89_00705	COG5544	Lipoprotein
LI89_00710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LI89_00730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LI89_00770	COG1879	ABC-type sugar transport system periplasmic component
LI89_00775	COG1129	ABC transporter
LI89_00780	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_00785	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_00790	COG0583	DNA-binding transcription factor activity
LI89_00795	COG3085	chromosome segregation
LI89_00810	COG3978	acetolactate synthase activity
LI89_00815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LI89_00820	COG0129	dihydroxy-acid dehydratase activity
LI89_00825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LI89_00835	COG0583	DNA-binding transcription factor activity
LI89_00840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LI89_00865	COG3121	Chaperone
LI89_00880	COG3121	Chaperone
LI89_00890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LI89_00905	COG0248	Ppx GppA phosphatase
LI89_00915	COG3118	belongs to the thioredoxin family
LI89_00920	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LI89_00925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LI89_00930	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LI89_00935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LI89_00940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LI89_00945	COG1088	dTDP-glucose 4,6-dehydratase activity
LI89_00950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LI89_00955	COG0456	acetyltransferase
LI89_00960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LI89_00965	COG2244	polysaccharide biosynthetic process
LI89_00970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI89_00985	COG1113	amino acid transport
LI89_01015	COG3071	HemY protein
LI89_01020	COG2959	enzyme of heme biosynthesis
LI89_01025	COG1587	Uroporphyrinogen-III synthase
LI89_01030	COG0181	hydroxymethylbilane synthase activity
LI89_01040	COG3072	Adenylate cyclase
LI89_01045	COG1965	Belongs to the frataxin family
LI89_01050	COG5567	small periplasmic lipoprotein
LI89_01055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LI89_01060	COG3159	Protein conserved in bacteria
LI89_01065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LI89_01070	COG1011	Hydrolase
LI89_01075	COG0210	DNA helicase
LI89_01085	COG5441	Belongs to the UPF0261 family
LI89_01090	COG5564	TIM-barrel signal transduction protein
LI89_01095	COG0598	Magnesium transport protein CorA
LI89_01105	COG2050	protein possibly involved in aromatic compounds catabolism
LI89_01110	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LI89_01115	COG0514	ATP-dependent DNA helicase (RecQ)
LI89_01120	COG1280	lysine exporter protein (LysE YggA)
LI89_01125	COG1280	lysine exporter protein (LysE YggA)
LI89_01130	COG2267	carboxylic ester hydrolase activity
LI89_01135	COG0561	phosphatase activity
LI89_01140	COG0584	glycerophosphoryl diester phosphodiesterase
LI89_01145	COG2271	Major facilitator Superfamily
LI89_01155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LI89_01160	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LI89_01165	COG0247	lactate metabolic process
LI89_01175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LI89_01180	COG0425	Belongs to the sulfur carrier protein TusA family
LI89_01185	COG2217	Heavy metal translocating P-type atpase
LI89_01190	COG3714	YhhN family
LI89_01205	COG3776	membrane
LI89_01210	COG0742	ribosomal rna small subunit methyltransferase
LI89_01215	COG0552	protein localization to endoplasmic reticulum
LI89_01220	COG2884	Cell division ATP-binding protein ftsE
LI89_01225	COG2177	Part of the ABC transporter FtsEX involved in
LI89_01240	COG0683	leucine binding
LI89_01245	COG0559	Belongs to the binding-protein-dependent transport system permease family
LI89_01250	COG4177	L-phenylalanine transmembrane transporter activity
LI89_01255	COG0411	ABC transporter
LI89_01260	COG0410	ABC transporter
LI89_01295	COG1653	transport
LI89_01300	COG1175	transmembrane transport
LI89_01305	COG0395	ABC-type sugar transport system, permease component
LI89_01310	COG3842	ATPase activity
LI89_01315	COG0584	glycerophosphoryl diester phosphodiesterase
LI89_01320	COG0679	Auxin Efflux Carrier
LI89_01330	COG0583	DNA-binding transcription factor activity
LI89_01335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LI89_01340	COG0412	Dienelactone hydrolase
LI89_01345	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LI89_01355	COG1966	Carbon starvation protein
LI89_01360	COG0586	Pfam SNARE associated Golgi protein
LI89_01365	COG1322	Protein conserved in bacteria
LI89_01370	COG2226	methyltransferase
LI89_01380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LI89_01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI89_01390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI89_01395	COG0805	protein transport
LI89_01415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LI89_01425	COG0183	Belongs to the thiolase family
LI89_01430	COG1024	Enoyl-CoA hydratase
LI89_01430	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI89_01435	COG0006	proline dipeptidase activity
LI89_01440	COG1739	Uncharacterized protein family UPF0029
LI89_01445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LI89_01480	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LI89_01480	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LI89_01485	COG1072	(Pantothenic acid kinase))
LI89_01515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LI89_01520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LI89_01525	COG0250	Participates in transcription elongation, termination and antitermination
LI89_01530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LI89_01535	COG0081	regulation of translation
LI89_01540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LI89_01545	COG0222	ribosome binding
LI89_01550	COG0085	RNA polymerase activity
LI89_01555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LI89_01565	COG2022	thiamine diphosphate biosynthetic process
LI89_01570	COG2104	thiamine diphosphate biosynthetic process
LI89_01575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LI89_01585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LI89_01590	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LI89_01595	COG2816	NAD+ diphosphatase activity
LI89_01605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LI89_01610	COG1515	deoxyribonuclease V activity
LI89_01615	COG3068	Protein conserved in bacteria
LI89_01630	COG0151	Belongs to the GarS family
LI89_01635	COG0138	bifunctional purine biosynthesis protein purh
LI89_01680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LI89_01685	COG3162	membrane
LI89_01690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LI89_01695	COG1301	dicarboxylic acid transport
LI89_01700	COG2197	response regulator
LI89_01705	COG2205	protein histidine kinase activity
LI89_01705	COG0784	Response regulator, receiver
LI89_01860	COG2391	methyltransferase activity
LI89_01865	COG0425	Belongs to the sulfur carrier protein TusA family
LI89_01885	COG3712	iron ion homeostasis
LI89_01890	COG4771	TonB-dependent receptor
LI89_01895	COG4178	(ABC) transporter
LI89_01900	COG0612	Peptidase, M16
LI89_01905	COG1511	domain protein
LI89_01905	COG3264	Mechanosensitive ion channel
LI89_01910	COG4774	siderophore transport
LI89_01920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_01925	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LI89_01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_01935	COG4558	Periplasmic binding protein
LI89_01940	COG3720	iron ion transport
LI89_01955	COG0702	epimerase
LI89_01960	COG3721	Heme iron utilization protein
LI89_01975	COG0814	amino acid
LI89_01980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LI89_01985	COG1882	Formate acetyltransferase
LI89_01995	COG1309	transcriptional regulator
LI89_02000	COG1929	Belongs to the glycerate kinase type-1 family
LI89_02005	COG4232	protein-disulfide reductase activity
LI89_02015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LI89_02030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LI89_02055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LI89_02065	COG2076	Multidrug Resistance protein
LI89_02075	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LI89_02080	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LI89_02085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LI89_02090	COG1053	succinate dehydrogenase
LI89_02095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LI89_02100	COG1511	domain protein
LI89_02100	COG3264	Mechanosensitive ion channel
LI89_02105	COG0688	phosphatidylethanolamine metabolic process
LI89_02110	COG1162	GTPase activity
LI89_02115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LI89_02135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LI89_02140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LI89_02140	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LI89_02145	COG0802	atpase or kinase
LI89_02150	COG0860	N-Acetylmuramoyl-L-alanine amidase
LI89_02155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LI89_02160	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LI89_02165	COG1923	regulation of RNA biosynthetic process
LI89_02170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LI89_02175	COG0330	HflC and HflK could
LI89_02180	COG0330	HflC and HflK could
LI89_02185	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LI89_02190	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LI89_02195	COG1959	2 iron, 2 sulfur cluster binding
LI89_02200	COG0557	exoribonuclease II activity
LI89_02205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI89_02210	COG1960	acyl-CoA dehydrogenase activity
LI89_02215	COG3650	response to hydrogen peroxide
LI89_02220	COG1073	alpha beta
LI89_02230	COG0360	Binds together with S18 to 16S ribosomal RNA
LI89_02235	COG2965	DNA replication, synthesis of RNA primer
LI89_02240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LI89_02245	COG0359	binds to the 23S rRNA
LI89_02255	COG3061	Opacity-associated protein A
LI89_02265	COG0545	Peptidyl-prolyl cis-trans isomerase
LI89_02275	COG0737	Belongs to the 5'-nucleotidase family
LI89_02280	COG1218	3'(2'),5'-bisphosphate nucleotidase
LI89_02285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LI89_02295	COG1253	flavin adenine dinucleotide binding
LI89_02300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LI89_02315	COG2105	PFAM AIG2 family protein
LI89_02320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LI89_02330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LI89_02335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LI89_02345	COG1438	arginine binding
LI89_02350	COG0039	L-malate dehydrogenase activity
LI89_02355	COG3423	Transcriptional regulator
LI89_02365	COG0142	geranyltranstransferase activity
LI89_02370	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LI89_02375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LI89_02380	COG0697	spore germination
LI89_02385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LI89_02390	COG0642	Histidine kinase
LI89_02395	COG0745	RESPONSE REGULATOR receiver
LI89_02400	COG2027	D-alanyl-D-alanine carboxypeptidase
LI89_02405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI89_02410	COG1534	Rna-binding protein
LI89_02415	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LI89_02420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LI89_02425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LI89_02430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LI89_02435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LI89_02450	COG0779	Required for maturation of 30S ribosomal subunits
LI89_02455	COG0195	Participates in both transcription termination and antitermination
LI89_02460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LI89_02465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LI89_02470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LI89_02475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LI89_02480	COG1185	polyribonucleotide nucleotidyltransferase activity
LI89_02490	COG0513	Belongs to the DEAD box helicase family
LI89_02500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI89_02505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_02510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_02520	COG0814	amino acid
LI89_02525	COG3681	Belongs to the UPF0597 family
LI89_02545	COG3153	acetyltransferase
LI89_02550	COG2827	Endonuclease containing a URI domain
LI89_02555	COG0531	amino acid
LI89_02560	COG1982	Orn Lys Arg decarboxylase major
LI89_02580	COG1653	transport
LI89_02590	COG0395	ABC-type sugar transport system, permease component
LI89_02595	COG3842	ATPase activity
LI89_02605	COG3787	Belongs to the UPF0306 family
LI89_02615	COG0702	epimerase
LI89_02620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LI89_02625	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LI89_02630	COG3454	Phosphonate metabolism
LI89_02635	COG4778	phosphonate C-P lyase system protein PhnL
LI89_02640	COG4107	phosphonate C-P lyase system protein PhnK
LI89_02645	COG3627	carbon phosphorus lyase activity
LI89_02650	COG3626	phosphonate metabolism
LI89_02655	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LI89_02660	COG3624	Phosphonate C-P lyase system protein PhnG
LI89_02665	COG2188	Transcriptional regulator
LI89_02690	COG0583	DNA-binding transcription factor activity
LI89_02695	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI89_02710	COG4608	Belongs to the ABC transporter superfamily
LI89_02715	COG0444	Belongs to the ABC transporter superfamily
LI89_02725	COG0601	transmembrane transport
LI89_02735	COG2731	YhcH YjgK YiaL family protein
LI89_02745	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LI89_02760	COG2927	DNA polymerase III (CHI subunit)
LI89_02765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LI89_02770	COG0795	lipopolysaccharide-transporting ATPase activity
LI89_02775	COG0795	lipopolysaccharide-transporting ATPase activity
LI89_02785	COG0582	viral genome integration into host DNA
LI89_02825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LI89_02915	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LI89_02920	COG1830	Aldolase
LI89_02925	COG1879	ABC-type sugar transport system periplasmic component
LI89_02930	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_02935	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_02940	COG1129	ABC transporter
LI89_02945	COG2390	Transcriptional regulator
LI89_02950	COG1070	Carbohydrate kinase
LI89_02955	COG0859	PFAM glycosyl transferase family 9
LI89_02975	COG2235	arginine
LI89_02980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_02985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_02995	COG2376	Dihydroxyacetone kinase
LI89_03000	COG1461	Dihydroxyacetone kinase
LI89_03005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI89_03005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_03005	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LI89_03015	COG2192	nodulation
LI89_03045	COG3284	Transcriptional regulator
LI89_03080	COG4772	TonB-dependent receptor
LI89_03085	COG3706	GGDEF domain
LI89_03110	COG0667	Aldo Keto reductase
LI89_03115	COG2813	Specifically methylates the guanine in position
LI89_03120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LI89_03125	COG0456	acetyltransferase
LI89_03130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LI89_03135	COG2823	Periplasmic or secreted lipoprotein
LI89_03145	COG4667	esterase of the alpha-beta hydrolase superfamily
LI89_03150	COG0084	hydrolase, TatD family'
LI89_03155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LI89_03160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LI89_03165	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LI89_03170	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LI89_03175	COG0813	purine-nucleoside phosphorylase activity
LI89_03180	COG3726	membrane protein affecting hemolysin expression
LI89_03185	COG0560	Phosphoserine phosphatase
LI89_03215	COG0604	alcohol dehydrogenase
LI89_03225	COG0488	(ABC) transporter
LI89_03230	COG2885	chlorophyll binding
LI89_03235	COG2199	diguanylate cyclase activity
LI89_03245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LI89_03250	COG0741	lytic transglycosylase activity
LI89_03255	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LI89_03260	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LI89_03265	COG0406	alpha-ribazole phosphatase activity
LI89_03270	COG2207	Transcriptional regulator
LI89_03270	COG3708	Transcriptional regulator
LI89_03275	COG3045	CreA protein
LI89_03280	COG0745	RESPONSE REGULATOR receiver
LI89_03295	COG0083	homoserine kinase activity
LI89_03305	COG3022	response to hydroperoxide
LI89_03310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LI89_03315	COG0521	Mo-molybdopterin cofactor biosynthetic process
LI89_03320	COG0477	Major facilitator Superfamily
LI89_03330	COG1584	GPR1 FUN34 yaaH family protein
LI89_03340	COG0484	heat shock protein binding
LI89_03345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LI89_03350	COG0583	DNA-binding transcription factor activity
LI89_03355	COG0268	Binds directly to 16S ribosomal RNA
LI89_03360	COG0196	riboflavin kinase activity
LI89_03365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LI89_03370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LI89_03375	COG1047	Peptidyl-prolyl cis-trans
LI89_03380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LI89_03385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LI89_03390	COG0505	Belongs to the CarA family
LI89_03395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LI89_03400	COG1280	lysine exporter protein (LysE YggA)
LI89_03405	COG2966	Psort location CytoplasmicMembrane, score
LI89_03410	COG3610	response to peptide
LI89_03415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LI89_03420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LI89_03425	COG2967	ApaG domain
LI89_03430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LI89_03435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LI89_03440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LI89_03445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LI89_03450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LI89_03455	COG0564	pseudouridine synthase activity
LI89_03465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LI89_03475	COG0417	DNA replication proofreading
LI89_03480	COG0586	Pfam SNARE associated Golgi protein
LI89_03490	COG1178	ABC-type Fe3 transport system permease component
LI89_03495	COG4143	(ABC) transporter
LI89_03510	COG4533	DNA binding
LI89_03515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LI89_03525	COG2814	Major facilitator Superfamily
LI89_03530	COG0814	amino acid
LI89_03535	COG3033	Beta-eliminating lyase
LI89_03550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LI89_03555	COG0473	3-isopropylmalate dehydrogenase activity
LI89_03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LI89_03570	COG1022	Amp-dependent synthetase and ligase
LI89_03575	COG0028	Belongs to the TPP enzyme family
LI89_03585	COG1609	Transcriptional regulator
LI89_03595	COG2001	Belongs to the MraZ family
LI89_03600	COG0275	rRNA processing
LI89_03605	COG3116	cell division
LI89_03610	COG0768	penicillin binding
LI89_03615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LI89_03620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LI89_03625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LI89_03635	COG0772	Belongs to the SEDS family
LI89_03640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LI89_03645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LI89_03655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LI89_03660	COG0849	cell division
LI89_03665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LI89_03685	COG0653	protein targeting
LI89_03690	COG0494	nUDIX hydrolase
LI89_03695	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LI89_03700	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LI89_03705	COG0237	dephospho-CoA kinase activity
LI89_03710	COG0516	GMP reductase activity
LI89_03715	COG1459	type II secretion system
LI89_03720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LI89_03725	COG4969	Belongs to the N-Me-Phe pilin family
LI89_03740	COG3725	Membrane protein required for beta-lactamase induction
LI89_03745	COG1113	amino acid transport
LI89_03750	COG2186	Transcriptional regulator
LI89_03755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LI89_03760	COG0508	dehydrogenase complex catalyzes the overall conversion of
LI89_03765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_03790	COG3112	Uncharacterised protein family (UPF0231)
LI89_03795	COG0697	spore germination
LI89_03825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LI89_03830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LI89_03840	COG2132	Multicopper oxidase
LI89_03850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LI89_03855	COG0288	reversible hydration of carbon dioxide
LI89_03860	COG1131	(ABC) transporter
LI89_03865	COG0842	Transport permease protein
LI89_03870	COG0726	polysaccharide deacetylase
LI89_03875	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LI89_03880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LI89_03885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LI89_03890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LI89_03905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LI89_03910	COG1489	DNA binding
LI89_03915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LI89_03920	COG1643	Atp-dependent helicase
LI89_03925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LI89_03930	COG1120	ATPase activity
LI89_03935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LI89_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_03945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LI89_03955	COG0316	Belongs to the HesB IscA family
LI89_03960	COG2860	membrane
LI89_03970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LI89_03975	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LI89_03980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_03985	COG3437	response regulator, receiver
LI89_03985	COG2205	protein histidine kinase activity
LI89_03985	COG4999	Histidine kinase
LI89_03985	COG3850	Histidine kinase
LI89_03990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_03995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LI89_04000	COG3956	TIGRFAM MazG family protein
LI89_04005	COG0504	CTP synthase activity
LI89_04010	COG0148	phosphopyruvate hydratase activity
LI89_04040	COG0602	queuosine metabolic process
LI89_04045	COG0720	synthase
LI89_04050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LI89_04055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LI89_04060	COG0175	sulfate reduction
LI89_04075	COG2234	aminopeptidase activity
LI89_04080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_04080	COG1648	precorrin-2 dehydrogenase activity
LI89_04085	COG0175	sulfate reduction
LI89_04090	COG2895	sulfate adenylyltransferase (ATP) activity
LI89_04095	COG0529	Catalyzes the synthesis of activated sulfate
LI89_04110	COG0765	amino acid transport
LI89_04120	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LI89_04130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LI89_04135	COG0585	pseudouridine synthase activity
LI89_04140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LI89_04145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LI89_04150	COG1388	LysM domain
LI89_04150	COG4942	peptidase
LI89_04155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LI89_04160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LI89_04185	COG3188	usher protein
LI89_04190	COG3121	Chaperone
LI89_04200	COG3539	Fimbrial protein
LI89_04205	COG3539	Fimbrial protein
LI89_04235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_04245	COG1538	Outer membrane efflux protein
LI89_04265	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_04285	COG0583	DNA-binding transcription factor activity
LI89_04295	COG2610	gluconate transmembrane transporter activity
LI89_04300	COG3048	D-serine ammonia-lyase activity
LI89_04315	COG0765	amino acid transport
LI89_04320	COG1126	abc transporter atp-binding protein
LI89_04325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI89_04330	COG3665	Urea carboxylase-associated protein
LI89_04345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LI89_04350	COG0640	Transcriptional regulator
LI89_04405	COG0410	ABC transporter
LI89_04410	COG1137	ATPase activity
LI89_04415	COG4177	L-phenylalanine transmembrane transporter activity
LI89_04420	COG0559	Belongs to the binding-protein-dependent transport system permease family
LI89_04430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_04430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_04435	COG1070	Carbohydrate kinase
LI89_04440	COG3623	hexulose-6-phosphate isomerase
LI89_04450	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_04465	COG1349	DNA-binding transcription factor activity
LI89_04470	COG0235	Class ii aldolase
LI89_04475	COG1349	DNA-binding transcription factor activity
LI89_04485	COG1070	Carbohydrate kinase
LI89_04495	COG0738	Major facilitator superfamily
LI89_04500	COG0235	Class ii aldolase
LI89_04505	COG1454	alcohol dehydrogenase
LI89_04510	COG0243	molybdopterin cofactor binding
LI89_04515	COG0437	4 iron, 4 sulfur cluster binding
LI89_04520	COG3302	dmso reductase anchor subunit
LI89_04525	COG3381	protein complex oligomerization
LI89_04540	COG1609	Transcriptional regulator
LI89_04550	COG1129	ABC transporter
LI89_04555	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_04560	COG3959	Transketolase, thiamine diphosphate binding domain
LI89_04565	COG3958	Transketolase
LI89_04570	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LI89_04595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LI89_04600	COG2137	regulation of response to DNA damage stimulus
LI89_04605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LI89_04610	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LI89_04635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_04640	COG1238	metal cluster binding
LI89_04645	COG2918	glutathione biosynthetic process
LI89_04650	COG1854	S-ribosylhomocysteine lyase activity
LI89_04655	COG4536	flavin adenine dinucleotide binding
LI89_04660	COG4137	Cytochrome C assembly protein
LI89_04665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LI89_04670	COG0228	four-way junction DNA binding
LI89_04675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LI89_04680	COG0336	Belongs to the RNA methyltransferase TrmD family
LI89_04685	COG0335	large ribosomal subunit rRNA binding
LI89_04690	COG3137	Salt-induced outer membrane protein
LI89_04695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LI89_04700	COG3279	Response regulator of the LytR AlgR family
LI89_04705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LI89_04710	COG0287	Prephenate dehydrogenase
LI89_04710	COG1605	Chorismate mutase
LI89_04715	COG0077	Prephenate dehydratase
LI89_04715	COG1605	Chorismate mutase
LI89_04720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LI89_04725	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI89_04730	COG0564	pseudouridine synthase activity
LI89_04740	COG0542	response to heat
LI89_04785	COG5544	Lipoprotein
LI89_04790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LI89_04795	COG1042	CoA-binding domain protein
LI89_04795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI89_04795	COG0045	succinate-CoA ligase (ADP-forming) activity
LI89_04805	COG3118	belongs to the thioredoxin family
LI89_04810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LI89_04815	COG2814	Major facilitator Superfamily
LI89_04820	COG1566	PFAM secretion protein HlyD family protein
LI89_04825	COG1538	Outer membrane efflux protein
LI89_04830	COG1846	Transcriptional regulator
LI89_04840	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LI89_04845	COG2814	Major facilitator Superfamily
LI89_04880	COG0765	amino acid transport
LI89_04885	COG0765	amino acid transport
LI89_04895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LI89_04910	COG0436	Aminotransferase
LI89_04915	COG0235	Class ii aldolase
LI89_04920	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LI89_04925	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LI89_04930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LI89_04935	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LI89_04950	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
LI89_04955	COG1960	acyl-CoA dehydrogenase activity
LI89_04960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LI89_04965	COG0121	glutamine amidotransferase
LI89_04970	COG3034	peptidoglycan biosynthetic process
LI89_04975	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_04980	COG1805	sodium ion transport
LI89_04985	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_04990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_04995	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LI89_05000	COG2871	sodium ion transport
LI89_05005	COG1477	protein flavinylation
LI89_05010	COG2991	Protein conserved in bacteria
LI89_05020	COG1181	Belongs to the D-alanine--D-alanine ligase family
LI89_05025	COG2964	Protein conserved in bacteria
LI89_05040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LI89_05045	COG2195	Cleaves the N-terminal amino acid of tripeptides
LI89_05050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LI89_05065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LI89_05070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LI89_05075	COG2188	Transcriptional regulator
LI89_05095	COG3459	Glycosyltransferase 36 associated
LI89_05110	COG2226	methyltransferase
LI89_05135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LI89_05140	COG3123	guanosine phosphorylase activity
LI89_05145	COG2974	May be involved in recombination
LI89_05150	COG1940	carbohydrate kinase activity
LI89_05155	COG0419	ATPase involved in DNA repair
LI89_05160	COG0420	3'-5' exonuclease activity
LI89_05165	COG0745	RESPONSE REGULATOR receiver
LI89_05170	COG5002	protein histidine kinase activity
LI89_05180	COG1114	Component of the transport system for branched-chain amino acids
LI89_05190	COG0366	Alpha amylase catalytic
LI89_05205	COG0450	alkyl hydroperoxide reductase
LI89_05210	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LI89_05215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LI89_05225	COG0343	queuine tRNA-ribosyltransferase activity
LI89_05230	COG1862	Preprotein translocase
LI89_05235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LI89_05240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LI89_05250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LI89_05255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LI89_05255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LI89_05260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LI89_05265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LI89_05270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LI89_05275	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LI89_05280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LI89_05285	COG0142	geranyltranstransferase activity
LI89_05290	COG1722	exodeoxyribonuclease VII activity
LI89_05295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LI89_05295	COG0301	tRNA thio-modification
LI89_05305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LI89_05310	COG1666	GTP binding
LI89_05315	COG2814	Major facilitator Superfamily
LI89_05320	COG0109	protoheme IX farnesyltransferase activity
LI89_05325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LI89_05330	COG1845	cytochrome c oxidase, subunit III
LI89_05335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LI89_05340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LI89_05355	COG2223	nitrite transmembrane transporter activity
LI89_05360	COG3056	Lipoprotein
LI89_05365	COG0271	Belongs to the BolA IbaG family
LI89_05370	COG0544	peptidyl-prolyl cis-trans isomerase activity
LI89_05375	COG0740	serine-type endopeptidase activity
LI89_05380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LI89_05385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LI89_05390	COG0776	regulation of translation
LI89_05400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LI89_05405	COG1555	photosystem II stabilization
LI89_05410	COG0824	Thioesterase
LI89_05415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LI89_05420	COG4533	DNA binding
LI89_05425	COG0561	phosphatase activity
LI89_05435	COG1522	sequence-specific DNA binding
LI89_05440	COG1132	(ABC) transporter
LI89_05445	COG1132	(ABC) transporter
LI89_05450	COG0347	Belongs to the P(II) protein family
LI89_05455	COG0004	ammonium transporteR
LI89_05460	COG1946	Acyl-CoA thioesterase
LI89_05470	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LI89_05475	COG3695	enzyme binding
LI89_05505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_05510	COG0803	Belongs to the bacterial solute-binding protein 9 family
LI89_05515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LI89_05520	COG0254	rRNA binding
LI89_05535	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LI89_05540	COG3457	Alanine racemase
LI89_05550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_05555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_05560	COG1309	transcriptional regulator
LI89_05565	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LI89_05570	COG1196	nuclear chromosome segregation
LI89_05570	COG3264	Mechanosensitive ion channel
LI89_05585	COG2832	Protein of unknown function (DUF454)
LI89_05590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LI89_05600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LI89_05605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LI89_05610	COG0326	Molecular chaperone. Has ATPase activity
LI89_05615	COG0563	adenylate kinase activity
LI89_05620	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LI89_05625	COG2244	polysaccharide biosynthetic process
LI89_05630	COG1442	glycosyl transferase family 8
LI89_05630	COG1216	Glycosyl transferase, family 2
LI89_05635	COG1216	Glycosyl transferase, family 2
LI89_05635	COG1442	glycosyl transferase family 8
LI89_05640	COG0438	transferase activity, transferring glycosyl groups
LI89_05670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_05675	COG4651	solute:proton antiporter activity
LI89_05675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LI89_05680	COG2223	nitrite transmembrane transporter activity
LI89_05685	COG0737	Belongs to the 5'-nucleotidase family
LI89_05690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LI89_05695	COG3735	TraB family
LI89_05700	COG2217	Heavy metal translocating P-type atpase
LI89_05705	COG0789	Transcriptional regulator
LI89_05710	COG1585	Membrane protein implicated in regulation of membrane protease activity
LI89_05715	COG0330	HflC and HflK could
LI89_05720	COG3118	belongs to the thioredoxin family
LI89_05725	COG0300	oxidoreductase activity
LI89_05730	COG2755	lipolytic protein G-D-S-L family
LI89_05735	COG4181	ATPase activity
LI89_05740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LI89_05745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LI89_05750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LI89_05755	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_05760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LI89_05765	COG0215	cysteine-tRNA ligase activity
LI89_05770	COG2501	S4 domain
LI89_05775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LI89_05795	COG1902	pentaerythritol trinitrate reductase activity
LI89_05810	COG0656	L-ascorbic acid biosynthetic process
LI89_05830	COG5002	protein histidine kinase activity
LI89_05855	COG2850	peptidyl-arginine hydroxylation
LI89_05860	COG2986	histidine ammonia-lyase
LI89_05875	COG5265	(ABC) transporter
LI89_05890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LI89_05900	COG2197	response regulator
LI89_05905	COG1278	Cold shock
LI89_05910	COG1278	Cold shock
LI89_05915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LI89_05920	COG3706	GGDEF domain
LI89_05925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LI89_05930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LI89_05935	COG0321	lipoyl(octanoyl) transferase activity
LI89_05940	COG2921	Belongs to the UPF0250 family
LI89_05945	COG1686	Belongs to the peptidase S11 family
LI89_05950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LI89_05955	COG0772	Belongs to the SEDS family
LI89_05960	COG0768	penicillin binding
LI89_05970	COG0799	negative regulation of ribosome biogenesis
LI89_05975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LI89_05980	COG1466	dna polymerase III delta subunit
LI89_05985	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LI89_05990	COG0495	leucyl-tRNA aminoacylation
LI89_05995	COG2888	peptidyl-tyrosine sulfation
LI89_06005	COG1126	abc transporter atp-binding protein
LI89_06010	COG0765	amino acid transport
LI89_06015	COG0765	amino acid transport
LI89_06030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LI89_06035	COG4535	Mg2 and Co2 transporter CorC
LI89_06040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LI89_06045	COG1702	phosphate starvation-inducible protein PhoH
LI89_06050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LI89_06055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI89_06090	COG0367	asparagine synthase
LI89_06095	COG0647	UMP catabolic process
LI89_06100	COG1846	Transcriptional regulator
LI89_06100	COG1940	carbohydrate kinase activity
LI89_06105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LI89_06110	COG0363	glucosamine-6-phosphate deaminase activity
LI89_06115	COG2190	(PTS) system
LI89_06115	COG1263	PTS System
LI89_06115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_06120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LI89_06140	COG0735	belongs to the Fur family
LI89_06150	COG0840	transmembrane signaling receptor activity
LI89_06160	COG0596	Alpha beta hydrolase
LI89_06165	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LI89_06170	COG0033	Phosphoglucomutase
LI89_06185	COG0745	RESPONSE REGULATOR receiver
LI89_06190	COG2205	protein histidine kinase activity
LI89_06195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LI89_06200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LI89_06205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LI89_06225	COG2994	toxin metabolic process
LI89_06230	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LI89_06230	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LI89_06230	COG1073	alpha beta
LI89_06230	COG3064	Membrane
LI89_06230	COG1073	alpha beta
LI89_06230	COG3064	Membrane
LI89_06235	COG3272	Protein of unknown function (DUF1722)
LI89_06245	COG5212	phosphodiesterase
LI89_06250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LI89_06260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LI89_06265	COG1984	allophanate hydrolase subunit 2
LI89_06270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LI89_06285	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LI89_06295	COG2009	succinate dehydrogenase
LI89_06300	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LI89_06305	COG1053	succinate dehydrogenase
LI89_06315	COG0567	Dehydrogenase, E1 component
LI89_06320	COG0508	dehydrogenase complex catalyzes the overall conversion of
LI89_06325	COG0045	succinate-CoA ligase (ADP-forming) activity
LI89_06330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LI89_06335	COG0737	Belongs to the 5'-nucleotidase family
LI89_06340	COG1271	oxidase subunit
LI89_06345	COG1294	oxidase, subunit
LI89_06350	COG4890	Cyd operon protein YbgT
LI89_06355	COG3790	cyd operon protein YbgE
LI89_06360	COG0824	Thioesterase
LI89_06365	COG0811	peptide transport
LI89_06370	COG0848	biopolymer transport protein
LI89_06375	COG3064	Membrane
LI89_06375	COG3064	Membrane
LI89_06380	COG0823	Involved in the tonB-independent uptake of proteins
LI89_06385	COG2885	chlorophyll binding
LI89_06390	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LI89_06415	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LI89_06425	COG1230	cation diffusion facilitator family transporter
LI89_06430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LI89_06435	COG0588	phosphoglycerate mutase activity
LI89_06450	COG2017	converts alpha-aldose to the beta-anomer
LI89_06455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LI89_06460	COG1085	galactose-1-phosphate uridylyltransferase
LI89_06465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LI89_06475	COG1119	ATPase activity
LI89_06480	COG3585	molybdate ion transport
LI89_06480	COG2005	Transcriptional regulator
LI89_06490	COG0725	ABC transporter, periplasmic molybdate-binding protein
LI89_06495	COG4149	molybdate abc transporter
LI89_06505	COG0561	phosphatase activity
LI89_06510	COG2706	6-phosphogluconolactonase activity
LI89_06520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LI89_06525	COG0156	8-amino-7-oxononanoate synthase activity
LI89_06530	COG2226	methyltransferase
LI89_06535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LI89_06545	COG0556	nucleotide-excision repair
LI89_06550	COG4628	conserved protein (DUF2132)
LI89_06555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LI89_06560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LI89_06565	COG0315	cyclic pyranopterin monophosphate synthase activity
LI89_06570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LI89_06575	COG0314	molybdopterin synthase activity
LI89_06580	COG0670	Belongs to the BI1 family
LI89_06585	COG0842	Transport permease protein
LI89_06590	COG0842	Transport permease protein
LI89_06595	COG1131	(ABC) transporter
LI89_06600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_06605	COG1309	transcriptional regulator
LI89_06610	COG0513	Belongs to the DEAD box helicase family
LI89_06615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LI89_06630	COG1686	Belongs to the peptidase S11 family
LI89_06640	COG0277	FAD linked oxidase domain protein
LI89_06650	COG1403	HNH endonuclease
LI89_06660	COG2261	transglycosylase associated protein
LI89_06670	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LI89_06685	COG4807	Protein conserved in bacteria
LI89_06705	COG0411	ABC transporter
LI89_06715	COG2897	thiosulfate sulfurtransferase activity
LI89_06735	COG1732	Glycine betaine
LI89_06740	COG1174	glycine betaine transport
LI89_06745	COG1125	glycine betaine transport
LI89_06750	COG1174	glycine betaine transport
LI89_06765	COG0583	DNA-binding transcription factor activity
LI89_06775	COG0697	spore germination
LI89_06795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LI89_06800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LI89_06820	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LI89_06830	COG1126	abc transporter atp-binding protein
LI89_06835	COG0765	amino acid transport
LI89_06840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_06845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LI89_06850	COG0783	Belongs to the Dps family
LI89_06855	COG4106	trans-aconitate 2-methyltransferase activity
LI89_06870	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LI89_06890	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LI89_06915	COG0488	(ABC) transporter
LI89_06920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LI89_06925	COG0303	'Molybdopterin
LI89_06940	COG1136	(ABC) transporter
LI89_06940	COG0577	efflux transmembrane transporter activity
LI89_06970	COG0583	DNA-binding transcription factor activity
LI89_06975	COG0477	Major facilitator Superfamily
LI89_06980	COG0302	gtp cyclohydrolase
LI89_06985	COG2311	Membrane
LI89_07010	COG2116	formate transmembrane transporter activity
LI89_07020	COG3383	formate dehydrogenase (NAD+) activity
LI89_07025	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LI89_07030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LI89_07040	COG3260	NADH ubiquinone oxidoreductase 20
LI89_07045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_07050	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LI89_07050	COG3261	NADH dehydrogenase
LI89_07055	COG0651	ATP synthesis coupled electron transport
LI89_07060	COG4237	Hydrogenase 4 membrane
LI89_07065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LI89_07070	COG0650	Formate hydrogenlyase subunit 4
LI89_07075	COG0651	ATP synthesis coupled electron transport
LI89_07080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LI89_07085	COG0375	protein maturation
LI89_07090	COG0298	carbon dioxide binding
LI89_07095	COG2949	membrane
LI89_07100	COG0281	malic enzyme
LI89_07115	COG1346	cytolysis
LI89_07120	COG1380	Effector of murein hydrolase LrgA
LI89_07125	COG2814	Major facilitator Superfamily
LI89_07145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LI89_07145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LI89_07150	COG0489	protein tyrosine kinase activity
LI89_07155	COG0572	uridine kinase
LI89_07165	COG2982	Protein involved in outer membrane biogenesis
LI89_07170	COG3069	C4-dicarboxylate transmembrane transporter activity
LI89_07175	COG1253	flavin adenine dinucleotide binding
LI89_07180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LI89_07185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LI89_07190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LI89_07195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LI89_07195	COG0140	phosphoribosyl-ATP diphosphatase activity
LI89_07200	COG0107	imidazoleglycerol-phosphate synthase activity
LI89_07205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LI89_07210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LI89_07215	COG0131	Imidazoleglycerol-phosphate dehydratase
LI89_07215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LI89_07220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI89_07230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LI89_07235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_07240	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_07245	COG1129	ABC transporter
LI89_07260	COG0371	Dehydrogenase
LI89_07270	COG0531	amino acid
LI89_07275	COG2925	Exonuclease
LI89_07280	COG1022	Amp-dependent synthetase and ligase
LI89_07280	COG3320	Male sterility
LI89_07285	COG1289	transmembrane transporter activity
LI89_07290	COG2926	Belongs to the UPF0265 family
LI89_07300	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_07310	COG1879	ABC-type sugar transport system periplasmic component
LI89_07330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LI89_07335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_07335	COG1648	precorrin-2 dehydrogenase activity
LI89_07340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LI89_07350	COG4810	utilization protein
LI89_07360	COG4656	Part of a membrane complex involved in electron transport
LI89_07375	COG2096	Adenosyltransferase
LI89_07400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LI89_07435	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LI89_07455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LI89_07465	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LI89_07470	COG2241	protein methyltransferase activity
LI89_07480	COG2875	Belongs to the precorrin methyltransferase family
LI89_07530	COG1492	cobalamin metabolic process
LI89_07550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LI89_07555	COG0583	DNA-binding transcription factor activity
LI89_07565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LI89_07570	COG2211	Major facilitator Superfamily
LI89_07630	COG3121	Chaperone
LI89_07705	COG0137	argininosuccinate synthase activity
LI89_07710	COG0534	Mate efflux family protein
LI89_07720	COG0352	thiamine-phosphate diphosphorylase activity
LI89_07725	COG0561	phosphatase activity
LI89_07730	COG1349	DNA-binding transcription factor activity
LI89_07740	COG0784	Response regulator, receiver
LI89_07740	COG0835	chemotaxis
LI89_07750	COG4221	oxidoreductase activity
LI89_07760	COG1129	ABC transporter
LI89_07780	COG4214	carbohydrate transport
LI89_07790	COG1063	alcohol dehydrogenase
LI89_07815	COG3121	Chaperone
LI89_07840	COG2205	protein histidine kinase activity
LI89_07840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_07910	COG3842	ATPase activity
LI89_07920	COG1840	ABC-type Fe3 transport system, periplasmic component
LI89_07925	COG2271	Major facilitator Superfamily
LI89_07940	COG4565	transcriptional regulatory protein
LI89_07945	COG3290	protein histidine kinase activity
LI89_07950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LI89_07955	COG3052	prosthetic group binding
LI89_07960	COG2301	Belongs to the HpcH HpaI aldolase family
LI89_07965	COG3051	citrate lyase alpha subunit
LI89_07980	COG0471	metal ion transport
LI89_07995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LI89_08010	COG2814	Major facilitator Superfamily
LI89_08015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_08015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_08040	COG0577	efflux transmembrane transporter activity
LI89_08040	COG1136	(ABC) transporter
LI89_08045	COG1136	(ABC) transporter
LI89_08045	COG0577	efflux transmembrane transporter activity
LI89_08050	COG3122	Protein conserved in bacteria
LI89_08065	COG3228	Belongs to the MtfA family
LI89_08075	COG1129	ABC transporter
LI89_08080	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_08085	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_08095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_08100	COG1070	Carbohydrate kinase
LI89_08125	COG3121	Chaperone
LI89_08135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LI89_08165	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_08165	COG0604	alcohol dehydrogenase
LI89_08165	COG3321	synthase
LI89_08170	COG3250	beta-galactosidase activity
LI89_08175	COG1609	Transcriptional regulator
LI89_08180	COG1278	Cold shock
LI89_08195	COG0840	transmembrane signaling receptor activity
LI89_08200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LI89_08205	COG1285	pathogenesis
LI89_08215	COG2130	NADP-dependent
LI89_08220	COG0589	response to stress
LI89_08240	COG1360	Flagellar Motor Protein
LI89_08245	COG2198	Histidine kinase
LI89_08245	COG0643	Histidine kinase
LI89_08250	COG0835	chemotaxis
LI89_08255	COG0840	transmembrane signaling receptor activity
LI89_08260	COG0840	transmembrane signaling receptor activity
LI89_08265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LI89_08275	COG0745	RESPONSE REGULATOR receiver
LI89_08280	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LI89_08285	COG4935	Belongs to the peptidase S8 family
LI89_08285	COG1404	Belongs to the peptidase S8 family
LI89_08290	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LI89_08295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LI89_08310	COG3418	PFAM FlgN family protein
LI89_08315	COG2747	anti-sigma28 factor FlgM
LI89_08325	COG1815	bacterial-type flagellum-dependent cell motility
LI89_08330	COG1558	bacterial-type flagellum-dependent cell motility
LI89_08335	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LI89_08340	COG1749	Flagellar hook protein flgE
LI89_08350	COG4786	Flagellar basal body rod
LI89_08375	COG1256	bacterial-type flagellum assembly
LI89_08395	COG1338	Plays a role in the flagellum-specific transport system
LI89_08415	COG1580	Controls the rotational direction of flagella during chemotaxis
LI89_08425	COG2882	bacterial-type flagellum organization
LI89_08435	COG1317	bacterial-type flagellum organization
LI89_08440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LI89_08450	COG1677	Flagellar hook-basal body complex protein FliE
LI89_08455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LI89_08460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LI89_08510	COG1191	sigma factor activity
LI89_08520	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LI89_08550	COG0506	proline dehydrogenase activity
LI89_08550	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LI89_08550	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LI89_08575	COG0655	NAD(P)H dehydrogenase (quinone) activity
LI89_08585	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
LI89_08590	COG2233	PERMEase
LI89_08595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LI89_08600	COG0778	Nitroreductase
LI89_08605	COG2267	carboxylic ester hydrolase activity
LI89_08610	COG0251	oxidation-reduction process
LI89_08615	COG1335	isochorismatase
LI89_08620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LI89_08625	COG1309	transcriptional regulator
LI89_08630	COG1113	amino acid transport
LI89_08650	COG2226	methyltransferase
LI89_08665	COG0366	Alpha amylase catalytic
LI89_08675	COG3136	membrane protein required for alginate biosynthesis
LI89_08685	COG2197	response regulator
LI89_08690	COG0322	excinuclease ABC activity
LI89_08695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LI89_08850	COG4695	Portal protein
LI89_08920	COG4974	Belongs to the 'phage' integrase family
LI89_09005	COG0305	Participates in initiation and elongation during chromosome replication
LI89_09060	COG3772	lysozyme
LI89_09150	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LI89_09240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LI89_09255	COG0561	phosphatase activity
LI89_09260	COG2223	nitrite transmembrane transporter activity
LI89_09270	COG0346	lactoylglutathione lyase activity
LI89_09295	COG3493	citrate carrier protein
LI89_09300	COG4565	transcriptional regulatory protein
LI89_09305	COG3290	protein histidine kinase activity
LI89_09310	COG1349	DNA-binding transcription factor activity
LI89_09315	COG3395	kinase activity
LI89_09320	COG0235	Class ii aldolase
LI89_09325	COG3622	Belongs to the hyi family
LI89_09330	COG2066	Belongs to the glutaminase family
LI89_09345	COG0672	)-iron permease
LI89_09360	COG0577	efflux transmembrane transporter activity
LI89_09360	COG1136	(ABC) transporter
LI89_09370	COG0577	efflux transmembrane transporter activity
LI89_09370	COG1136	(ABC) transporter
LI89_09395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LI89_09400	COG4114	ferric iron reductase
LI89_09405	COG0006	proline dipeptidase activity
LI89_09410	COG0457	Tetratricopeptide repeat
LI89_09415	COG0726	polysaccharide deacetylase
LI89_09415	COG1649	PFAM Uncharacterised BCR, COG1649
LI89_09420	COG1215	transferase activity, transferring glycosyl groups
LI89_09425	COG3658	cytochrome
LI89_09440	COG1702	phosphate starvation-inducible protein PhoH
LI89_09445	COG0387	Pfam Sodium calcium exchanger
LI89_09455	COG2814	Major facilitator Superfamily
LI89_09460	COG0583	DNA-binding transcription factor activity
LI89_09465	COG3850	Histidine kinase
LI89_09475	COG1294	oxidase, subunit
LI89_09480	COG1271	oxidase subunit
LI89_09485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_09490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LI89_09495	COG3138	arginine N-succinyltransferase
LI89_09505	COG3724	N-succinylarginine dihydrolase activity
LI89_09510	COG2988	succinylglutamate desuccinylase activity
LI89_09525	COG1228	amidohydrolase
LI89_09535	COG0402	S-adenosylhomocysteine deaminase activity
LI89_09545	COG3443	Belongs to the bacterial solute-binding protein 9 family
LI89_09560	COG4942	peptidase
LI89_09570	COG2222	sugar isomerase
LI89_09575	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_09580	COG3716	PTS system mannose fructose sorbose family IID component
LI89_09590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_09600	COG1349	DNA-binding transcription factor activity
LI89_09615	COG1187	pseudouridine synthase activity
LI89_09620	COG0786	glutamate:sodium symporter activity
LI89_09640	COG0668	transmembrane transport
LI89_09645	COG0625	glutathione transferase activity
LI89_09675	COG5001	Diguanylate cyclase
LI89_09675	COG4251	negative regulation of phosphorylation
LI89_09675	COG2203	Gaf domain
LI89_09675	COG3706	GGDEF domain
LI89_09710	COG2814	Major facilitator Superfamily
LI89_09720	COG3008	intermembrane lipid transfer
LI89_09725	COG2995	paraquat-inducible protein a
LI89_09730	COG1956	GAF domain-containing protein
LI89_09740	COG0793	Belongs to the peptidase S41A family
LI89_09745	COG0501	Belongs to the peptidase M48B family
LI89_09770	COG2814	Major facilitator Superfamily
LI89_09775	COG0823	Involved in the tonB-independent uptake of proteins
LI89_09785	COG3023	N-Acetylmuramoyl-L-alanine amidase
LI89_09795	COG1988	membrane-bound metal-dependent
LI89_09800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LI89_09805	COG1653	transport
LI89_09810	COG3842	ATPase activity
LI89_09815	COG0395	ABC-type sugar transport system, permease component
LI89_09820	COG1175	transmembrane transport
LI89_09830	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_09835	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LI89_09840	COG1917	Cupin 2, conserved barrel domain protein
LI89_09845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_09855	COG0583	DNA-binding transcription factor activity
LI89_09860	COG0427	acetyl-CoA hydrolase
LI89_09865	COG1024	Enoyl-CoA hydratase
LI89_09870	COG1703	isobutyryl-CoA mutase activity
LI89_09875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI89_09875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI89_09885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_09890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_09895	COG1121	(ABC) transporter
LI89_09900	COG0803	Belongs to the bacterial solute-binding protein 9 family
LI89_09935	COG1811	Na channel or pump
LI89_09940	COG4249	Peptidase C14 caspase catalytic subunit p20
LI89_09950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LI89_09955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LI89_09960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LI89_09965	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LI89_09970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LI89_09980	COG0776	regulation of translation
LI89_09995	COG4139	cobalamin transport
LI89_10000	COG0386	Belongs to the glutathione peroxidase family
LI89_10005	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LI89_10010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LI89_10015	COG0463	Glycosyl transferase, family 2
LI89_10020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_10020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LI89_10025	COG0726	polysaccharide deacetylase
LI89_10030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LI89_10035	COG2076	Multidrug Resistance protein
LI89_10040	COG2076	Multidrug Resistance protein
LI89_10045	COG0791	NLP P60 protein
LI89_10050	COG0095	Lipoate-protein ligase
LI89_10060	COG4558	Periplasmic binding protein
LI89_10065	COG3720	iron ion transport
LI89_10070	COG4771	TonB-dependent receptor
LI89_10085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LI89_10090	COG0574	Belongs to the PEP-utilizing enzyme family
LI89_10090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI89_10095	COG0628	permease
LI89_10100	COG0247	lactate metabolic process
LI89_10100	COG0277	FAD linked oxidase domain protein
LI89_10105	COG2050	protein possibly involved in aromatic compounds catabolism
LI89_10110	COG0316	Belongs to the HesB IscA family
LI89_10115	COG0719	Fe-S assembly protein
LI89_10120	COG0396	ATPase activity
LI89_10125	COG0719	Fe-S assembly protein
LI89_10135	COG2166	iron-sulfur cluster assembly
LI89_10140	COG1376	ErfK ybiS ycfS ynhG family protein
LI89_10140	COG1388	LysM domain
LI89_10145	COG4238	major outer membrane lipoprotein
LI89_10170	COG0534	Mate efflux family protein
LI89_10175	COG0307	riboflavin synthase, alpha
LI89_10180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LI89_10185	COG2814	Major facilitator Superfamily
LI89_10190	COG0583	DNA-binding transcription factor activity
LI89_10195	COG1609	Transcriptional regulator
LI89_10205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LI89_10210	COG0791	NLP P60 protein
LI89_10215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LI89_10220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LI89_10225	COG0346	lactoylglutathione lyase activity
LI89_10230	COG1902	pentaerythritol trinitrate reductase activity
LI89_10235	COG1309	transcriptional regulator
LI89_10240	COG2194	sulfuric ester hydrolase activity
LI89_10245	COG3313	Fe-S protein
LI89_10250	COG4989	oxidoreductase activity
LI89_10255	COG1289	transmembrane transporter activity
LI89_10260	COG1566	PFAM secretion protein HlyD family protein
LI89_10270	COG1846	Transcriptional regulator
LI89_10275	COG3133	Outer membrane lipoprotein
LI89_10280	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LI89_10285	COG3895	Periplasmic Protein
LI89_10290	COG0259	pyridoxamine-phosphate oxidase activity
LI89_10295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LI89_10305	COG0625	glutathione transferase activity
LI89_10330	COG3104	oligopeptide transport
LI89_10340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI89_10340	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI89_10350	COG4172	Belongs to the ABC transporter superfamily
LI89_10360	COG4171	peptide transport system, permease
LI89_10365	COG4168	peptide transport system, permease
LI89_10385	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LI89_10390	COG1842	Phage shock protein A
LI89_10400	COG1983	PspC domain protein
LI89_10410	COG3106	COG3106 Predicted ATPase
LI89_10415	COG3768	UPF0283 membrane protein
LI89_10435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LI89_10440	COG4948	Mandelate Racemase Muconate Lactonizing
LI89_10445	COG2866	Carboxypeptidase
LI89_10450	COG4166	transmembrane transport
LI89_10465	COG0598	Magnesium transport protein CorA
LI89_10470	COG0037	tRNA processing
LI89_10475	COG3711	transcriptional antiterminator
LI89_10480	COG1263	PTS System
LI89_10480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_10480	COG2190	(PTS) system
LI89_10485	COG2723	6-phospho-beta-galactosidase activity
LI89_10490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_10490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LI89_10490	COG0674	pyruvate-flavodoxin oxidoreductase activity
LI89_10490	COG1013	pyruvate-flavodoxin oxidoreductase activity
LI89_10500	COG1285	pathogenesis
LI89_10505	COG3042	response to heat
LI89_10510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_10515	COG2911	Protein conserved in bacteria
LI89_10525	COG3784	Protein of unknown function (DUF1318)
LI89_10535	COG1070	Carbohydrate kinase
LI89_10540	COG0246	Mannitol dehydrogenase
LI89_10550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LI89_10555	COG1643	Atp-dependent helicase
LI89_10570	COG3591	Belongs to the peptidase S1B family
LI89_10585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LI89_10590	COG2205	protein histidine kinase activity
LI89_10595	COG0745	RESPONSE REGULATOR receiver
LI89_10605	COG0531	amino acid
LI89_10620	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LI89_10625	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LI89_10630	COG0589	response to stress
LI89_10635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LI89_10640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LI89_10655	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LI89_10665	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_10675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_10680	COG0738	Major facilitator superfamily
LI89_10700	COG1011	Hydrolase
LI89_10705	COG0440	acetolactate synthase activity
LI89_10710	COG0028	Belongs to the TPP enzyme family
LI89_10730	COG2271	Major facilitator Superfamily
LI89_10735	COG0483	inositol monophosphate 1-phosphatase activity
LI89_10745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LI89_10750	COG0583	DNA-binding transcription factor activity
LI89_10755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_10775	COG4215	(ABC) transporter
LI89_10785	COG1522	sequence-specific DNA binding
LI89_10795	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI89_10800	COG1773	rubredoxin
LI89_10800	COG0426	domain, Protein
LI89_10805	COG3604	Transcriptional regulator
LI89_10825	COG0625	glutathione transferase activity
LI89_10860	COG0477	Major facilitator Superfamily
LI89_10865	COG4221	oxidoreductase activity
LI89_10870	COG1742	UPF0060 membrane protein
LI89_10905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LI89_10910	COG1940	carbohydrate kinase activity
LI89_10915	COG0583	DNA-binding transcription factor activity
LI89_10920	COG2814	Major facilitator Superfamily
LI89_10945	COG0114	fumarate hydratase activity
LI89_10955	COG5339	Protein conserved in bacteria
LI89_10965	COG1609	Transcriptional regulator
LI89_10970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_10970	COG1263	PTS System
LI89_10975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LI89_10980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LI89_10985	COG0385	Bile acid
LI89_10990	COG0673	inositol 2-dehydrogenase activity
LI89_11000	COG1172	Belongs to the binding-protein-dependent transport system permease family
LI89_11010	COG1879	ABC-type sugar transport system periplasmic component
LI89_11020	COG2160	L-arabinose isomerase activity
LI89_11045	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LI89_11060	COG4657	Part of a membrane complex involved in electron transport
LI89_11070	COG4656	Part of a membrane complex involved in electron transport
LI89_11075	COG2207	Transcriptional regulator
LI89_11075	COG3708	Transcriptional regulator
LI89_11080	COG4658	electron transport chain
LI89_11085	COG4659	FMN binding
LI89_11095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LI89_11110	COG0243	molybdopterin cofactor binding
LI89_11115	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LI89_11120	COG1966	Carbon starvation protein
LI89_11125	COG2879	small protein
LI89_11130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LI89_11135	COG1349	DNA-binding transcription factor activity
LI89_11145	COG0235	Class ii aldolase
LI89_11155	COG0023	Translation Initiation Factor
LI89_11160	COG0284	orotidine-5'-phosphate decarboxylase activity
LI89_11175	COG3135	benzoate transporter
LI89_11180	COG1396	sequence-specific DNA binding
LI89_11190	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LI89_11195	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LI89_11200	COG0671	phosphoesterase, PA-phosphatase related
LI89_11205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LI89_11210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LI89_11225	COG4974	Belongs to the 'phage' integrase family
LI89_11300	COG0583	DNA-binding transcription factor activity
LI89_11305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LI89_11315	COG0616	signal peptide processing
LI89_11320	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_11325	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LI89_11335	COG1187	pseudouridine synthase activity
LI89_11340	COG0009	L-threonylcarbamoyladenylate synthase
LI89_11345	COG0613	PHP domain protein
LI89_11355	COG0512	Glutamine amidotransferase of anthranilate synthase
LI89_11365	COG0135	phosphoribosylanthranilate isomerase activity
LI89_11365	COG0134	indole-3-glycerol-phosphate synthase activity
LI89_11370	COG0133	tryptophan synthase activity
LI89_11375	COG0159	tryptophan synthase activity
LI89_11385	COG3047	cAMP biosynthetic process
LI89_11405	COG2917	probably involved in intracellular septation
LI89_11410	COG1607	acyl-coa hydrolase
LI89_11415	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LI89_11420	COG2350	Protein conserved in bacteria
LI89_11435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LI89_11440	COG3099	Belongs to the UPF0263 family
LI89_11450	COG0444	Belongs to the ABC transporter superfamily
LI89_11455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_11475	COG2095	MarC family integral membrane protein
LI89_11480	COG1454	alcohol dehydrogenase
LI89_11480	COG1012	belongs to the aldehyde dehydrogenase family
LI89_11485	COG1435	thymidine kinase activity
LI89_11495	COG2916	Histone family protein nucleoid-structuring protein H-NS
LI89_11505	COG0745	RESPONSE REGULATOR receiver
LI89_11510	COG1752	Esterase of the alpha-beta hydrolase superfamily
LI89_11520	COG3012	SEC-C Motif Domain Protein
LI89_11525	COG0788	formyltetrahydrofolate deformylase activity
LI89_11545	COG0583	DNA-binding transcription factor activity
LI89_11550	COG0708	Exodeoxyribonuclease III
LI89_11555	COG0494	nUDIX hydrolase
LI89_11565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LI89_11575	COG0778	Nitroreductase
LI89_11580	COG0616	signal peptide processing
LI89_11585	COG0252	asparaginase activity
LI89_11590	COG1335	isochorismatase
LI89_11595	COG3139	Protein of unknown function (DUF1315)
LI89_11600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LI89_11615	COG3713	MltA-interacting MipA family protein
LI89_11620	COG2766	serine protein kinase
LI89_11625	COG2718	Belongs to the UPF0229 family
LI89_11640	COG0583	DNA-binding transcription factor activity
LI89_11650	COG2200	EAL domain
LI89_11650	COG2202	Pas domain
LI89_11650	COG2199	diguanylate cyclase activity
LI89_11655	COG2814	Major facilitator Superfamily
LI89_11660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LI89_11665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI89_11670	COG2719	SpoVR family
LI89_11675	COG2186	Transcriptional regulator
LI89_11680	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LI89_11685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LI89_11690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_11700	COG2983	Belongs to the UPF0260 family
LI89_11705	COG0179	Fumarylacetoacetate (FAA) hydrolase
LI89_11710	COG2951	lytic endotransglycosylase activity
LI89_11715	COG3100	YcgL domain-containing protein
LI89_11725	COG0850	regulation of cytokinetic process
LI89_11730	COG2894	cell division
LI89_11735	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LI89_11740	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LI89_11745	COG0318	PFAM AMP-dependent synthetase and ligase
LI89_11750	COG3065	identical protein binding
LI89_11760	COG1199	ATP-dependent helicase activity
LI89_11765	COG0251	oxidation-reduction process
LI89_11770	COG2076	Multidrug Resistance protein
LI89_11775	COG2076	Multidrug Resistance protein
LI89_11780	COG0800	Aldolase
LI89_11785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LI89_11790	COG1737	Transcriptional regulator
LI89_11795	COG0469	pyruvate kinase activity
LI89_11800	COG1560	Kdo2-lipid A biosynthetic process
LI89_11805	COG0739	heme binding
LI89_11810	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LI89_11815	COG1121	(ABC) transporter
LI89_11820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LI89_11825	COG3104	oligopeptide transport
LI89_11830	COG2255	four-way junction helicase activity
LI89_11835	COG0632	four-way junction helicase activity
LI89_11840	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LI89_11845	COG0217	transcriptional regulatory protein
LI89_11850	COG0494	nUDIX hydrolase
LI89_11855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LI89_11860	COG1335	isochorismatase
LI89_11865	COG1801	Protein of unknown function DUF72
LI89_11870	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LI89_11875	COG2226	methyltransferase
LI89_11880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI89_11885	COG3142	Participates in the control of copper homeostasis
LI89_11890	COG3102	Protein conserved in bacteria
LI89_11895	COG0018	arginyl-trna synthetase
LI89_11900	COG0728	peptidoglycan biosynthetic process
LI89_11905	COG0673	inositol 2-dehydrogenase activity
LI89_11915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI89_11945	COG0477	Major facilitator Superfamily
LI89_11955	COG3381	protein complex oligomerization
LI89_11960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LI89_11965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_11985	COG3706	GGDEF domain
LI89_11990	COG0659	secondary active sulfate transmembrane transporter activity
LI89_11995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LI89_12000	COG2912	Transglutaminase-like superfamily
LI89_12005	COG3094	Invasion gene expression up-regulator, SirB
LI89_12010	COG2890	protein-(glutamine-N5) methyltransferase activity
LI89_12015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LI89_12020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LI89_12025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LI89_12035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LI89_12050	COG0193	aminoacyl-tRNA hydrolase activity
LI89_12060	COG0012	GTP binding
LI89_12065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_12075	COG4948	Mandelate Racemase Muconate Lactonizing
LI89_12080	COG0800	Aldolase
LI89_12085	COG3734	2-keto-3-deoxy-galactonokinase
LI89_12090	COG2186	Transcriptional regulator
LI89_12105	COG2979	Protein of unknown function (DUF533)
LI89_12110	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LI89_12115	COG3772	lysozyme
LI89_12150	COG0488	(ABC) transporter
LI89_12220	COG2826	transposase and inactivated derivatives, IS30 family
LI89_12320	COG1276	copper resistance
LI89_12325	COG2372	response to copper ion
LI89_12330	COG1528	Iron-storage protein
LI89_12350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LI89_12355	COG1770	oligopeptidase
LI89_12370	COG3141	response to X-ray
LI89_12375	COG0513	Belongs to the DEAD box helicase family
LI89_12380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LI89_12385	COG3140	Belongs to the UPF0181 family
LI89_12395	COG0494	nUDIX hydrolase
LI89_12400	COG1760	l-serine dehydratase
LI89_12405	COG1253	flavin adenine dinucleotide binding
LI89_12410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_12410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_12415	COG3715	PTS system
LI89_12420	COG3716	PTS system mannose fructose sorbose family IID component
LI89_12425	COG4811	Protein of unknown function (DUF986)
LI89_12430	COG1971	Probably functions as a manganese efflux pump
LI89_12440	COG5002	protein histidine kinase activity
LI89_12440	COG3447	MASE1 domain protein
LI89_12440	COG5001	Diguanylate cyclase
LI89_12450	COG2226	methyltransferase
LI89_12455	COG0768	penicillin binding
LI89_12465	COG1278	Cold shock
LI89_12480	COG1113	amino acid transport
LI89_12515	COG2207	Transcriptional regulator
LI89_12540	COG1132	(ABC) transporter
LI89_12560	COG5001	Diguanylate cyclase
LI89_12560	COG4251	negative regulation of phosphorylation
LI89_12560	COG2203	Gaf domain
LI89_12560	COG3706	GGDEF domain
LI89_12575	COG3755	Protein conserved in bacteria
LI89_12590	COG2271	Major facilitator Superfamily
LI89_12595	COG4948	Mandelate Racemase Muconate Lactonizing
LI89_12600	COG1802	Transcriptional regulator
LI89_12605	COG1063	alcohol dehydrogenase
LI89_12610	COG0246	Mannitol dehydrogenase
LI89_12615	COG2721	sulfolactate sulfo-lyase activity
LI89_12620	COG1126	abc transporter atp-binding protein
LI89_12625	COG0765	amino acid transport
LI89_12630	COG0765	amino acid transport
LI89_12655	COG1733	regulation of RNA biosynthetic process
LI89_12660	COG0702	epimerase
LI89_12665	COG2873	o-acetylhomoserine
LI89_12685	COG3772	lysozyme
LI89_12760	COG0538	isocitrate dehydrogenase activity
LI89_12765	COG1187	pseudouridine synthase activity
LI89_12775	COG0482	sulfurtransferase activity
LI89_12780	COG2915	High frequency lysogenization protein hflD homolog
LI89_12785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LI89_12795	COG0745	RESPONSE REGULATOR receiver
LI89_12805	COG2850	peptidyl-arginine hydroxylation
LI89_12815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LI89_12820	COG1940	carbohydrate kinase activity
LI89_12830	COG4591	ABC-type transport system involved in lipoprotein release permease component
LI89_12840	COG4591	ABC-type transport system involved in lipoprotein release permease component
LI89_12845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LI89_12850	COG3134	Outer membrane lipoprotein
LI89_12855	COG1252	NADH dehydrogenase
LI89_12860	COG3150	esterase
LI89_12865	COG1472	Belongs to the glycosyl hydrolase 3 family
LI89_12870	COG0510	thiamine kinase activity
LI89_12875	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LI89_12880	COG5633	Lipoprotein
LI89_12885	COG0537	adenosine 5'-monophosphoramidase activity
LI89_12890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI89_12900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_12900	COG1263	PTS System
LI89_12905	COG0084	hydrolase, TatD family'
LI89_12910	COG0470	DNA polymerase III
LI89_12915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LI89_12920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LI89_12925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LI89_12930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI89_12940	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_12945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LI89_12950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LI89_12955	COG0416	fatty acid biosynthetic process
LI89_12960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LI89_12965	COG1399	metal-binding, possibly nucleic acid-binding protein
LI89_12975	COG0564	pseudouridine synthase activity
LI89_12980	COG1530	ribonuclease E activity
LI89_12980	COG1530	ribonuclease E activity
LI89_12985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LI89_12990	COG0418	dihydroorotase activity
LI89_13015	COG0628	permease
LI89_13055	COG1560	Kdo2-lipid A biosynthetic process
LI89_13060	COG2259	Doxx family
LI89_13065	COG2814	Major facilitator Superfamily
LI89_13070	COG3104	oligopeptide transport
LI89_13080	COG5645	(Lipo)protein
LI89_13085	COG2943	transferase activity, transferring hexosyl groups
LI89_13090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LI89_13105	COG3263	regulation of cellular component size
LI89_13115	COG3916	Acyl-homoserine-lactone synthase
LI89_13120	COG2771	luxR family
LI89_13125	COG4235	cytochrome complex assembly
LI89_13130	COG3088	subunit of a heme lyase
LI89_13140	COG1138	Cytochrome C-type biogenesis protein
LI89_13145	COG3301	Polysulphide reductase, NrfD
LI89_13150	COG0437	4 iron, 4 sulfur cluster binding
LI89_13155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LI89_13175	COG2920	part of a sulfur-relay system
LI89_13180	COG1254	Belongs to the acylphosphatase family
LI89_13195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LI89_13200	COG3785	DNA binding
LI89_13205	COG1832	CoA-binding protein
LI89_13210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LI89_13215	COG1803	Methylglyoxal synthase
LI89_13220	COG0210	DNA helicase
LI89_13225	COG3304	Inner membrane component domain
LI89_13230	COG1289	transmembrane transporter activity
LI89_13235	COG3070	regulator of competence-specific genes
LI89_13240	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
LI89_13245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LI89_13245	COG2885	chlorophyll binding
LI89_13250	COG3120	sequence-specific DNA binding
LI89_13255	COG1067	ATP-dependent peptidase activity
LI89_13260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LI89_13270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI89_13275	COG3009	Protein conserved in bacteria
LI89_13280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI89_13280	COG3008	intermembrane lipid transfer
LI89_13285	COG2995	paraquat-inducible protein a
LI89_13290	COG0488	(ABC) transporter
LI89_13295	COG0116	Belongs to the methyltransferase superfamily
LI89_13295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LI89_13300	COG0633	Ferredoxin
LI89_13300	COG3217	Mosc domain protein beta barrel domain protein
LI89_13310	COG0167	dihydroorotate dehydrogenase activity
LI89_13315	COG0308	aminopeptidase N
LI89_13320	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LI89_13325	COG0017	Asparaginyl-tRNA synthetase
LI89_13335	COG1448	Aminotransferase
LI89_13340	COG2200	EAL domain
LI89_13345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI89_13350	COG3108	Peptidase M15
LI89_13355	COG2989	Protein conserved in bacteria
LI89_13360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LI89_13365	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LI89_13370	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LI89_13375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI89_13380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LI89_13385	COG3173	Aminoglycoside phosphotransferase
LI89_13390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LI89_13395	COG2835	tetraacyldisaccharide 4'-kinase activity
LI89_13400	COG1278	Cold shock
LI89_13405	COG1278	Cold shock
LI89_13410	COG5383	Protein conserved in bacteria
LI89_13415	COG1663	tetraacyldisaccharide 4'-kinase activity
LI89_13425	COG2333	competence protein COMEC
LI89_13425	COG0658	competence protein
LI89_13430	COG0776	regulation of translation
LI89_13435	COG0539	negative regulation of cytoplasmic translation
LI89_13440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LI89_13445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LI89_13450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LI89_13455	COG2323	membrane
LI89_13460	COG0252	asparaginase activity
LI89_13465	COG1944	ATP diphosphatase activity
LI89_13470	COG2116	formate transmembrane transporter activity
LI89_13475	COG1882	Formate acetyltransferase
LI89_13480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LI89_13485	COG2814	Major facilitator Superfamily
LI89_13490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LI89_13495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LI89_13500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LI89_13505	COG1674	ftsk spoiiie
LI89_13505	COG3107	peptidoglycan biosynthetic process
LI89_13510	COG1522	sequence-specific DNA binding
LI89_13515	COG0492	ferredoxin-NADP+ reductase activity
LI89_13525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LI89_13530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LI89_13535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LI89_13540	COG0542	response to heat
LI89_13545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LI89_13550	COG1278	Cold shock
LI89_13560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_13565	COG2990	Protein conserved in bacteria
LI89_13570	COG3593	DNA synthesis involved in DNA repair
LI89_13575	COG2431	L-lysine efflux transmembrane transporter activity
LI89_13580	COG1151	hydroxylamine reductase activity
LI89_13585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI89_13590	COG0028	Belongs to the TPP enzyme family
LI89_13595	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LI89_13600	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LI89_13605	COG0702	epimerase
LI89_13610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_13620	COG1126	abc transporter atp-binding protein
LI89_13625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_13630	COG4215	(ABC) transporter
LI89_13635	COG4160	amino acid transport
LI89_13650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_13655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LI89_13665	COG1177	transmembrane transport
LI89_13670	COG1176	ABC-type spermidine putrescine transport system, permease component I
LI89_13675	COG3842	ATPase activity
LI89_13680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LI89_13695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_13700	COG0569	domain protein
LI89_13700	COG2985	domain, Protein
LI89_13710	COG0671	phosphoesterase, PA-phosphatase related
LI89_13715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LI89_13720	COG1349	DNA-binding transcription factor activity
LI89_13725	COG0814	amino acid
LI89_13730	COG1760	l-serine dehydratase
LI89_13735	COG1686	Belongs to the peptidase S11 family
LI89_13745	COG0626	cystathionine gamma-synthase activity
LI89_13760	COG2011	ABC-type metal ion transport system permease component
LI89_13785	COG0625	glutathione transferase activity
LI89_13790	COG4771	TonB-dependent receptor
LI89_13800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_13805	COG0833	amino acid
LI89_13810	COG0583	DNA-binding transcription factor activity
LI89_13820	COG2855	membrane
LI89_13825	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LI89_13850	COG3710	Transcriptional regulator
LI89_13855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LI89_13855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LI89_13855	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LI89_13860	COG1105	Belongs to the carbohydrate kinase PfkB family
LI89_13875	COG3005	denitrification pathway
LI89_13880	COG0243	molybdopterin cofactor binding
LI89_13895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LI89_13900	COG1312	Catalyzes the dehydration of D-mannonate
LI89_13910	COG0246	Mannitol dehydrogenase
LI89_13915	COG2186	Transcriptional regulator
LI89_13925	COG0523	cobalamin synthesis protein
LI89_13930	COG0671	phosphoesterase, PA-phosphatase related
LI89_13935	COG0791	NLP P60 protein
LI89_13945	COG2200	EAL domain
LI89_13950	COG4166	transmembrane transport
LI89_13955	COG4174	ABC transporter (Permease)
LI89_13960	COG4239	(ABC) transporter, permease
LI89_13965	COG4172	Belongs to the ABC transporter superfamily
LI89_13975	COG2814	Major facilitator Superfamily
LI89_13980	COG1187	pseudouridine synthase activity
LI89_13985	COG1061	Type III restriction enzyme res subunit
LI89_13995	COG3081	Nucleoid-associated protein
LI89_14000	COG3082	Protein of unknown function (DUF1414)
LI89_14025	COG2723	6-phospho-beta-galactosidase activity
LI89_14030	COG1263	PTS System
LI89_14030	COG2190	(PTS) system
LI89_14030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_14035	COG1737	Transcriptional regulator
LI89_14080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LI89_14100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LI89_14110	COG1132	(ABC) transporter
LI89_14125	COG2223	nitrite transmembrane transporter activity
LI89_14130	COG0642	Histidine kinase
LI89_14130	COG2198	Histidine kinase
LI89_14140	COG0784	Response regulator, receiver
LI89_14140	COG2205	protein histidine kinase activity
LI89_14150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LI89_14155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI89_14165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI89_14170	COG4574	serine-type endopeptidase inhibitor activity
LI89_14190	COG0814	amino acid
LI89_14215	COG1441	menaquinone biosynthetic process
LI89_14220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LI89_14225	COG0596	Alpha beta hydrolase
LI89_14230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LI89_14235	COG1169	isochorismate synthase
LI89_14240	COG4575	ribosome binding
LI89_14245	COG0129	dihydroxy-acid dehydratase activity
LI89_14250	COG4702	Belongs to the UPF0303 family
LI89_14260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_14265	COG1609	Transcriptional regulator
LI89_14270	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_14275	COG3265	gluconokinase activity
LI89_14305	COG1007	ATP synthesis coupled electron transport
LI89_14310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_14315	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LI89_14320	COG0713	ATP synthesis coupled electron transport
LI89_14325	COG0839	Belongs to the complex I subunit 6 family
LI89_14330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_14335	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LI89_14340	COG1034	ATP synthesis coupled electron transport
LI89_14350	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LI89_14355	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_14355	COG0649	NAD binding
LI89_14360	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_14365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LI89_14370	COG0583	DNA-binding transcription factor activity
LI89_14380	COG0436	Aminotransferase
LI89_14390	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LI89_14395	COG0471	metal ion transport
LI89_14395	COG0490	domain, Protein
LI89_14405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_14410	COG3013	Belongs to the UPF0304 family
LI89_14415	COG3092	negative regulation of chromosome organization
LI89_14425	COG0280	phosphate acetyltransferase
LI89_14425	COG0857	belongs to the CobB CobQ family
LI89_14430	COG1609	Transcriptional regulator
LI89_14435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_14445	COG3037	sugar-specific permease SgaT UlaA
LI89_14450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LI89_14455	COG0622	Phosphoesterase
LI89_14465	COG1090	epimerase
LI89_14470	COG4598	ABC transporter
LI89_14475	COG4160	amino acid transport
LI89_14480	COG4215	(ABC) transporter
LI89_14485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_14495	COG0163	prenyltransferase activity
LI89_14500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LI89_14505	COG1286	toxin biosynthetic process
LI89_14510	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LI89_14515	COG0285	dihydrofolate synthase activity
LI89_14525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LI89_14530	COG0586	Pfam SNARE associated Golgi protein
LI89_14540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LI89_14545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_14555	COG0697	spore germination
LI89_14560	COG0697	spore germination
LI89_14570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_14575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LI89_14600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LI89_14610	COG1609	Transcriptional regulator
LI89_14620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_14625	COG2723	6-phospho-beta-galactosidase activity
LI89_14630	COG1447	Phosphotransferase system cellobiose-specific component IIA
LI89_14640	COG1794	racemase activity, acting on amino acids and derivatives
LI89_14645	COG3706	GGDEF domain
LI89_14650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LI89_14655	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LI89_14655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LI89_14665	COG3101	peptidyl-lysine hydroxylation
LI89_14670	COG0730	response to heat
LI89_14675	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LI89_14680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LI89_14685	COG2890	protein-(glutamine-N5) methyltransferase activity
LI89_14695	COG2840	Smr protein MutS2
LI89_14700	COG2062	phosphohistidine phosphatase, SixA
LI89_14705	COG1250	3-hydroxyacyl-CoA dehydrogenase
LI89_14705	COG1024	Enoyl-CoA hydratase
LI89_14710	COG0183	Belongs to the thiolase family
LI89_14715	COG3691	Protein conserved in bacteria
LI89_14740	COG3088	subunit of a heme lyase
LI89_14740	COG4235	cytochrome complex assembly
LI89_14750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LI89_14755	COG1138	Cytochrome C-type biogenesis protein
LI89_14760	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LI89_14765	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI89_14770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI89_14780	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LI89_14790	COG2116	formate transmembrane transporter activity
LI89_14830	COG4977	sequence-specific DNA binding
LI89_14850	COG3188	usher protein
LI89_14860	COG3121	Chaperone
LI89_14870	COG3121	Chaperone
LI89_14880	COG2831	hemolysin activation secretion protein
LI89_15000	COG2824	Alkylphosphonate utilization operon protein PhnA
LI89_15005	COG1695	Transcriptional regulator
LI89_15015	COG2723	6-phospho-beta-galactosidase activity
LI89_15020	COG1263	PTS System
LI89_15020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_15025	COG1609	Transcriptional regulator
LI89_15030	COG2353	YceI-like domain
LI89_15035	COG3038	cytochrome b561
LI89_15040	COG0657	acetylesterase activity
LI89_15040	COG2755	lipolytic protein G-D-S-L family
LI89_15060	COG1127	ABC transporter
LI89_15065	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI89_15085	COG0531	amino acid
LI89_15090	COG2951	lytic endotransglycosylase activity
LI89_15110	COG1280	lysine exporter protein (LysE YggA)
LI89_15120	COG2723	6-phospho-beta-galactosidase activity
LI89_15140	COG1598	PFAM Uncharacterised protein family UPF0150
LI89_15145	COG3038	cytochrome b561
LI89_15150	COG0436	Aminotransferase
LI89_15165	COG3275	phosphorelay sensor kinase activity
LI89_15170	COG3279	Response regulator of the LytR AlgR family
LI89_15175	COG2223	nitrite transmembrane transporter activity
LI89_15180	COG0837	glucose binding
LI89_15195	COG3961	Belongs to the TPP enzyme family
LI89_15200	COG0667	Aldo Keto reductase
LI89_15210	COG1914	H( )-stimulated, divalent metal cation uptake system
LI89_15215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LI89_15240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LI89_15270	COG3530	Putative quorum-sensing-regulated virulence factor
LI89_15275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LI89_15290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LI89_15295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_15300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LI89_15305	COG2190	(PTS) system
LI89_15310	COG2205	protein histidine kinase activity
LI89_15315	COG0745	RESPONSE REGULATOR receiver
LI89_15320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_15340	COG4208	sulfate ABC transporter
LI89_15345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LI89_15350	COG4150	thiosulfate binding
LI89_15360	COG1737	Transcriptional regulator
LI89_15365	COG2731	YhcH YjgK YiaL family protein
LI89_15380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI89_15385	COG2837	iron assimilation
LI89_15400	COG3111	PFAM Bacterial OB fold (BOF) protein
LI89_15410	COG0456	acetyltransferase
LI89_15415	COG0408	coproporphyrinogen oxidase activity
LI89_15420	COG1671	Belongs to the UPF0178 family
LI89_15445	COG0494	nUDIX hydrolase
LI89_15450	COG3005	denitrification pathway
LI89_15455	COG3043	anaerobic respiration
LI89_15460	COG0243	molybdopterin cofactor binding
LI89_15465	COG3062	negative regulation of establishment of protein localization
LI89_15475	COG2197	response regulator
LI89_15485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_15685	COG1393	Belongs to the ArsC family
LI89_15690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LI89_15695	COG1876	peptidase activity
LI89_15705	COG0400	carboxylic ester hydrolase activity
LI89_15710	COG1444	tRNA N-acetyltransferase activity
LI89_15715	COG2707	UPF0756 membrane protein
LI89_15720	COG2321	neutral zinc metallopeptidase
LI89_15725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LI89_15730	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LI89_15735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LI89_15740	COG2716	regulation of RNA biosynthetic process
LI89_15745	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LI89_15750	COG0628	permease
LI89_15755	COG4783	chaperone-mediated protein folding
LI89_15760	COG1393	Belongs to the ArsC family
LI89_15765	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LI89_15770	COG2233	PERMEase
LI89_15775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LI89_15780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LI89_15785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LI89_15790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LI89_15810	COG0581	inorganic phosphate transmembrane transporter activity
LI89_15815	COG0573	inorganic phosphate transmembrane transporter activity
LI89_15820	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LI89_15825	COG0248	Ppx GppA phosphatase
LI89_15835	COG2239	Acts as a magnesium transporter
LI89_15840	COG3447	MASE1 domain protein
LI89_15840	COG5002	protein histidine kinase activity
LI89_15840	COG5001	Diguanylate cyclase
LI89_15845	COG0443	Heat shock 70 kDa protein
LI89_15850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_15860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_15870	COG0477	Major facilitator Superfamily
LI89_15875	COG2205	protein histidine kinase activity
LI89_15880	COG0745	RESPONSE REGULATOR receiver
LI89_15885	COG3422	double-strand break repair
LI89_15905	COG1597	lipid kinase activity
LI89_15910	COG3730	PTS system glucitol sorbitol-specific
LI89_15925	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_15930	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_15935	COG1349	DNA-binding transcription factor activity
LI89_15955	COG0351	phosphomethylpyrimidine kinase
LI89_15990	COG0519	Catalyzes the synthesis of GMP from XMP
LI89_15990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LI89_15995	COG0516	GMP reductase activity
LI89_15995	COG0517	IMP dehydrogenase activity
LI89_16000	COG1570	exodeoxyribonuclease VII activity
LI89_16005	COG1645	bacterial-type flagellum-dependent swarming motility
LI89_16015	COG1160	GTP binding
LI89_16025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI89_16030	COG2976	Protein conserved in bacteria
LI89_16035	COG0124	histidyl-tRNA synthetase
LI89_16040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LI89_16045	COG1426	Protein conserved in bacteria
LI89_16055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LI89_16065	COG0105	UTP biosynthetic process
LI89_16075	COG4953	penicillin-binding protein 1C
LI89_16080	COG2373	Large extracellular alpha-helical protein
LI89_16085	COG3468	outer membrane autotransporter barrel domain protein
LI89_16090	COG3468	outer membrane autotransporter barrel domain protein
LI89_16105	COG2975	iron-sulfur cluster assembly
LI89_16110	COG0633	Ferredoxin
LI89_16115	COG0443	Heat shock 70 kDa protein
LI89_16120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LI89_16125	COG0316	Belongs to the HesB IscA family
LI89_16130	COG0822	iron-sulfur transferase activity
LI89_16140	COG1959	2 iron, 2 sulfur cluster binding
LI89_16145	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LI89_16150	COG0483	inositol monophosphate 1-phosphatase activity
LI89_16155	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LI89_16160	COG3683	transport system, periplasmic component
LI89_16165	COG3711	transcriptional antiterminator
LI89_16170	COG2814	Major facilitator Superfamily
LI89_16175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LI89_16180	COG1017	nitric oxide dioxygenase activity
LI89_16180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LI89_16185	COG2188	Transcriptional regulator
LI89_16195	COG3457	Alanine racemase
LI89_16200	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LI89_16215	COG0347	Belongs to the P(II) protein family
LI89_16220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LI89_16220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI89_16225	COG2204	response regulator
LI89_16230	COG3170	Tfp pilus assembly protein FimV
LI89_16235	COG2205	protein histidine kinase activity
LI89_16250	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LI89_16255	COG0590	tRNA wobble adenosine to inosine editing
LI89_16265	COG0560	Phosphoserine phosphatase
LI89_16275	COG1737	Transcriptional regulator
LI89_16280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LI89_16285	COG2610	gluconate transmembrane transporter activity
LI89_16290	COG0736	holo-[acyl-carrier-protein] synthase activity
LI89_16295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LI89_16300	COG1381	Involved in DNA repair and RecF pathway recombination
LI89_16305	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LI89_16310	COG0571	ribonuclease III activity
LI89_16315	COG0681	Belongs to the peptidase S26 family
LI89_16320	COG0481	GTPase activity
LI89_16330	COG3086	response to oxidative stress
LI89_16340	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LI89_16355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LI89_16360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LI89_16365	COG0513	Belongs to the DEAD box helicase family
LI89_16380	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LI89_16385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LI89_16390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LI89_16395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LI89_16400	COG0497	DNA recombination
LI89_16405	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LI89_16415	COG2867	negative regulation of translational initiation
LI89_16420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LI89_16425	COG0582	viral genome integration into host DNA
LI89_16495	COG2826	transposase and inactivated derivatives, IS30 family
LI89_16505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LI89_16525	COG1902	pentaerythritol trinitrate reductase activity
LI89_16545	COG1063	alcohol dehydrogenase
LI89_16550	COG3547	Transposase (IS116 IS110 IS902 family)
LI89_16570	COG2826	transposase and inactivated derivatives, IS30 family
LI89_16625	COG0659	secondary active sulfate transmembrane transporter activity
LI89_16630	COG3394	polysaccharide catabolic process
LI89_16635	COG1917	Cupin 2, conserved barrel domain protein
LI89_16635	COG2169	Transcriptional regulator
LI89_16640	COG1447	Phosphotransferase system cellobiose-specific component IIA
LI89_16645	COG2723	6-phospho-beta-galactosidase activity
LI89_16650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_16655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_16660	COG2133	pyrroloquinoline quinone binding
LI89_16670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LI89_16675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LI89_16685	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LI89_16690	COG4413	Urea transporter
LI89_16695	COG0829	nickel cation binding
LI89_16700	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LI89_16705	COG0830	nickel cation binding
LI89_16710	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LI89_16715	COG0804	urea catabolic process
LI89_16745	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LI89_16750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_16785	COG1278	Cold shock
LI89_16810	COG2207	Transcriptional regulator
LI89_16830	COG4575	ribosome binding
LI89_16840	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LI89_16845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LI89_16850	COG1780	Probably involved in ribonucleotide reductase function
LI89_16860	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LI89_16865	COG4175	Glycine betaine
LI89_16870	COG4176	ABC-type proline glycine betaine transport system permease component
LI89_16875	COG2113	Glycine betaine
LI89_16885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LI89_16890	COG0328	RNA-DNA hybrid ribonuclease activity
LI89_16895	COG2226	methyltransferase
LI89_16900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LI89_16905	COG1388	LysM domain
LI89_16905	COG0741	lytic transglycosylase activity
LI89_16910	COG3021	interspecies interaction between organisms
LI89_16915	COG2814	Major facilitator Superfamily
LI89_16920	COG0583	DNA-binding transcription factor activity
LI89_16925	COG0656	L-ascorbic acid biosynthetic process
LI89_16935	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_16975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LI89_16990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LI89_17045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LI89_17055	COG2011	ABC-type metal ion transport system permease component
LI89_17060	COG1464	Belongs to the NlpA lipoprotein family
LI89_17070	COG1720	tRNA m6t6A37 methyltransferase activity
LI89_17080	COG0442	prolyl-tRNA aminoacylation
LI89_17085	COG3015	lipoprotein NlpE involved in copper resistance
LI89_17095	COG4681	YaeQ
LI89_17105	COG4568	rho-dependent transcription termination
LI89_17115	COG0037	tRNA processing
LI89_17120	COG0346	lactoylglutathione lyase activity
LI89_17130	COG0825	malonyl-CoA metabolic process
LI89_17135	COG0587	DNA-directed DNA polymerase activity
LI89_17140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LI89_17145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_17150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_17155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LI89_17160	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LI89_17165	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LI89_17175	COG0750	zinc metalloprotease
LI89_17180	COG0575	Belongs to the CDS family
LI89_17185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LI89_17190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LI89_17195	COG0233	cytoplasmic translational termination
LI89_17200	COG0528	UMP kinase activity
LI89_17205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LI89_17210	COG0052	Belongs to the universal ribosomal protein uS2 family
LI89_17220	COG0024	Methionine aminopeptidase
LI89_17225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LI89_17230	COG2171	N-acyltransferase activity
LI89_17245	COG0564	pseudouridine synthase activity
LI89_17250	COG3098	single-species biofilm formation
LI89_17265	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LI89_17265	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LI89_17270	COG1611	Belongs to the LOG family
LI89_17275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LI89_17280	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LI89_17285	COG2363	Small membrane protein
LI89_17290	COG0583	DNA-binding transcription factor activity
LI89_17300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LI89_17305	COG2166	iron-sulfur cluster assembly
LI89_17310	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LI89_17315	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LI89_17335	COG0860	N-Acetylmuramoyl-L-alanine amidase
LI89_17340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LI89_17340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LI89_17345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LI89_17350	COG1074	ATP-dependent DNA helicase activity
LI89_17355	COG1025	Belongs to the peptidase M16 family
LI89_17360	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LI89_17385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LI89_17390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LI89_17400	COG1051	belongs to the nudix hydrolase family
LI89_17410	COG3066	DNA modification
LI89_17415	COG0861	Integral membrane protein TerC family
LI89_17420	COG0667	Aldo Keto reductase
LI89_17425	COG0477	Major facilitator Superfamily
LI89_17430	COG0204	Acyl-transferase
LI89_17430	COG0318	PFAM AMP-dependent synthetase and ligase
LI89_17440	COG1609	Transcriptional regulator
LI89_17445	COG0019	diaminopimelate decarboxylase activity
LI89_17450	COG0583	DNA-binding transcription factor activity
LI89_17455	COG2814	Major facilitator Superfamily
LI89_17475	COG0840	transmembrane signaling receptor activity
LI89_17495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LI89_17525	COG2165	general secretion pathway protein
LI89_17555	COG0288	reversible hydration of carbon dioxide
LI89_17560	COG1733	regulation of RNA biosynthetic process
LI89_17565	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_17575	COG0484	heat shock protein binding
LI89_17585	COG2271	Major facilitator Superfamily
LI89_17600	COG1522	sequence-specific DNA binding
LI89_17605	COG3706	GGDEF domain
LI89_17610	COG4319	ketosteroid isomerase
LI89_17615	COG1393	Belongs to the ArsC family
LI89_17620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LI89_17755	COG0582	viral genome integration into host DNA
LI89_17765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LI89_17770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LI89_17775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LI89_17780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LI89_17785	COG4974	Belongs to the 'phage' integrase family
LI89_17790	COG0716	FMN binding
LI89_17795	COG4452	Inner membrane protein CreD
LI89_17800	COG2205	protein histidine kinase activity
LI89_17805	COG0745	RESPONSE REGULATOR receiver
LI89_17815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LI89_17820	COG0354	folic acid binding
LI89_17825	COG1272	protein, Hemolysin III
LI89_17835	COG1028	Short-chain dehydrogenase reductase Sdr
LI89_17845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LI89_17845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LI89_17855	COG0509	glycine decarboxylation via glycine cleavage system
LI89_17860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LI89_17865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI89_17870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LI89_17875	COG0006	proline dipeptidase activity
LI89_17880	COG3079	Belongs to the UPF0149 family
LI89_17885	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LI89_17890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LI89_17895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LI89_17900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LI89_17905	COG0583	DNA-binding transcription factor activity
LI89_17915	COG1279	arginine transmembrane transporter activity
LI89_17925	COG0191	fructose-bisphosphate aldolase activity
LI89_17930	COG0126	phosphoglycerate kinase activity
LI89_17935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LI89_17940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LI89_17945	COG0501	Belongs to the peptidase M48B family
LI89_17955	COG1166	arginine decarboxylase activity
LI89_17965	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LI89_17980	COG0640	Transcriptional regulator
LI89_17985	COG3091	SprT-like family
LI89_17990	COG2356	endonuclease I
LI89_17995	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LI89_18000	COG0189	ligase activity
LI89_18005	COG1678	Uncharacterized ACR, COG1678
LI89_18010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LI89_18015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI89_18025	COG2805	Type II/IV secretion system protein
LI89_18030	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LI89_18035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LI89_18040	COG0762	integral membrane protein
LI89_18045	COG1872	DUF167
LI89_18050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LI89_18055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LI89_18065	COG2066	Belongs to the glutaminase family
LI89_18070	COG3171	Protein conserved in bacteria
LI89_18075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LI89_18080	COG1194	a g-specific adenine glycosylase
LI89_18085	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LI89_18090	COG0741	lytic transglycosylase activity
LI89_18100	COG1982	Orn Lys Arg decarboxylase major
LI89_18115	COG0745	RESPONSE REGULATOR receiver
LI89_18125	COG2205	protein histidine kinase activity
LI89_18130	COG2197	response regulator
LI89_18150	COG0531	amino acid
LI89_18155	COG1982	Orn Lys Arg decarboxylase major
LI89_18165	COG1289	transmembrane transporter activity
LI89_18190	COG0024	Methionine aminopeptidase
LI89_18195	COG4604	ABC transporter, ATP-binding protein
LI89_18200	COG4605	iron ion homeostasis
LI89_18210	COG4607	ABC-type enterochelin transport system periplasmic component
LI89_18225	COG0697	spore germination
LI89_18230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_18240	COG0477	Major facilitator Superfamily
LI89_18245	COG1609	Transcriptional regulator
LI89_18255	COG1283	sodium-dependent phosphate transmembrane transporter activity
LI89_18270	COG0477	Major facilitator Superfamily
LI89_18280	COG2197	response regulator
LI89_18295	COG5001	Diguanylate cyclase
LI89_18310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LI89_18315	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LI89_18320	COG0309	Hydrogenase expression formation protein (HypE)
LI89_18325	COG0409	Hydrogenase expression formation protein
LI89_18330	COG0298	carbon dioxide binding
LI89_18335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LI89_18340	COG0375	protein maturation
LI89_18345	COG1773	rubredoxin
LI89_18350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LI89_18355	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LI89_18360	COG5557	Pfam Polysulphide reductase, NrfD
LI89_18365	COG0437	4 iron, 4 sulfur cluster binding
LI89_18370	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LI89_18375	COG3133	Outer membrane lipoprotein
LI89_18400	COG0840	transmembrane signaling receptor activity
LI89_18405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LI89_18410	COG2271	Major facilitator Superfamily
LI89_18415	COG4592	Periplasmic binding protein
LI89_18420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_18425	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LI89_18430	COG1120	ATPase activity
LI89_18440	COG4774	siderophore transport
LI89_18460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LI89_18465	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LI89_18495	COG4964	Belongs to the GSP D family
LI89_18545	COG0848	biopolymer transport protein
LI89_18550	COG0811	peptide transport
LI89_18560	COG0586	Pfam SNARE associated Golgi protein
LI89_18565	COG2207	Transcriptional regulator
LI89_18570	COG1979	alcohol dehydrogenase
LI89_18575	COG0656	L-ascorbic acid biosynthetic process
LI89_18590	COG2132	Multicopper oxidase
LI89_18595	COG0204	Acyl-transferase
LI89_18600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LI89_18605	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI89_18610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LI89_18620	COG0187	DNA topoisomerase II activity
LI89_18625	COG3150	esterase
LI89_18630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LI89_18635	COG3151	Protein conserved in bacteria
LI89_18640	COG0494	nUDIX hydrolase
LI89_18645	COG1538	Outer membrane efflux protein
LI89_18650	COG5463	Belongs to the UPF0441 family
LI89_18655	COG0754	glutathionylspermidine amidase activity
LI89_18660	COG3384	dioxygenase
LI89_18665	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LI89_18675	COG0531	amino acid
LI89_18680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LI89_18680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LI89_18685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LI89_18690	COG3025	triphosphatase activity
LI89_18695	COG4991	sh3 domain protein
LI89_18700	COG0617	tRNA 3'-terminal CCA addition
LI89_18705	COG1968	undecaprenyl-diphosphatase activity
LI89_18710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LI89_18715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LI89_18720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LI89_18730	COG0358	DNA primase activity
LI89_18735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LI89_18760	COG2003	Belongs to the UPF0758 family
LI89_18785	COG2378	regulation of single-species biofilm formation
LI89_18795	COG3596	GTP binding
LI89_18810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_18815	COG0501	Belongs to the peptidase M48B family
LI89_18860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LI89_18870	COG0542	response to heat
LI89_18875	COG0071	Belongs to the small heat shock protein (HSP20) family
LI89_18920	COG4983	Phage plasmid primase, P4 family domain protein
LI89_18950	COG3876	Protein conserved in bacteria
LI89_18960	COG1472	Belongs to the glycosyl hydrolase 3 family
LI89_18970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LI89_18975	COG1263	PTS System
LI89_18975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_18980	COG2066	Belongs to the glutaminase family
LI89_18985	COG0531	amino acid
LI89_18990	COG0076	glutamate decarboxylase activity
LI89_19000	COG2814	Major facilitator Superfamily
LI89_19005	COG3247	response to pH
LI89_19015	COG0446	pyridine nucleotide-disulphide oxidoreductase
LI89_19015	COG1902	pentaerythritol trinitrate reductase activity
LI89_19020	COG2813	Specifically methylates the guanine in position
LI89_19030	COG1451	nucleotide metabolic process
LI89_19035	COG0673	inositol 2-dehydrogenase activity
LI89_19040	COG0861	Integral membrane protein TerC family
LI89_19045	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LI89_19055	COG2721	sulfolactate sulfo-lyase activity
LI89_19060	COG0246	Mannitol dehydrogenase
LI89_19065	COG1904	glucuronate isomerase
LI89_19070	COG2271	Major facilitator Superfamily
LI89_19085	COG0586	Pfam SNARE associated Golgi protein
LI89_19100	COG4575	ribosome binding
LI89_19105	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LI89_19115	COG2259	Doxx family
LI89_19120	COG0435	Glutathione S-transferase
LI89_19125	COG0583	DNA-binding transcription factor activity
LI89_19130	COG1741	Belongs to the pirin family
LI89_19135	COG1064	alcohol dehydrogenase
LI89_19140	COG0667	Aldo Keto reductase
LI89_19205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LI89_19215	COG0792	nuclease activity
LI89_19220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LI89_19225	COG2823	Periplasmic or secreted lipoprotein
LI89_19230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LI89_19235	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LI89_19240	COG5002	protein histidine kinase activity
LI89_19240	COG2198	Histidine kinase
LI89_19240	COG0784	Response regulator, receiver
LI89_19245	COG1242	4 iron, 4 sulfur cluster binding
LI89_19250	COG0069	glutamate synthase activity
LI89_19250	COG0067	glutamate synthase
LI89_19250	COG0070	glutamate synthase
LI89_19255	COG0493	'glutamate synthase
LI89_19265	COG2969	positive regulation of protein catabolic process
LI89_19270	COG0625	glutathione transferase activity
LI89_19280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LI89_19285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LI89_19290	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LI89_19295	COG3105	Protein conserved in bacteria
LI89_19300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_19305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LI89_19310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LI89_19315	COG5007	Belongs to the BolA IbaG family
LI89_19320	COG3113	response to antibiotic
LI89_19325	COG2854	intermembrane phospholipid transfer
LI89_19330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LI89_19335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LI89_19340	COG1127	ABC transporter
LI89_19345	COG0530	calcium, potassium:sodium antiporter activity
LI89_19350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LI89_19350	COG0517	IMP dehydrogenase activity
LI89_19355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LI89_19360	COG3117	lipopolysaccharide transmembrane transporter activity
LI89_19365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LI89_19370	COG1137	ATPase activity
LI89_19375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LI89_19385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_19390	COG1660	Displays ATPase and GTPase activities
LI89_19395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_19405	COG0540	Belongs to the ATCase OTCase family
LI89_19410	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LI89_19425	COG2308	Evidence 4 Homologs of previously reported genes of
LI89_19450	COG0366	Alpha amylase catalytic
LI89_19455	COG1263	PTS System
LI89_19455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_19465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LI89_19475	COG3093	addiction module antidote protein HigA
LI89_19480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_19480	COG3711	transcriptional antiterminator
LI89_19500	COG3964	amidohydrolase
LI89_19530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI89_19535	COG3783	Cytochrome b(562)
LI89_19540	COG0312	modulator of DNA gyrase
LI89_19545	COG3028	Belongs to the UPF0307 family
LI89_19550	COG2732	(Barnase) inhibitor
LI89_19565	COG1289	transmembrane transporter activity
LI89_19570	COG1566	PFAM secretion protein HlyD family protein
LI89_19580	COG0583	DNA-binding transcription factor activity
LI89_19625	COG0312	modulator of DNA gyrase
LI89_19630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LI89_19635	COG3164	Protein of unknown function
LI89_19640	COG1530	ribonuclease E activity
LI89_19650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LI89_19655	COG1792	Involved in formation and maintenance of cell shape
LI89_19660	COG1077	Cell shape determining protein MreB Mrl
LI89_19665	COG2199	diguanylate cyclase activity
LI89_19665	COG2200	EAL domain
LI89_19670	COG0604	alcohol dehydrogenase
LI89_19680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LI89_19685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LI89_19690	COG0511	ligase activity, forming carbon-carbon bonds
LI89_19695	COG0439	Biotin carboxylase
LI89_19700	COG3924	membrane
LI89_19705	COG4145	pantothenate transmembrane transporter activity
LI89_19710	COG2264	protein methyltransferase activity
LI89_19715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LI89_19720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LI89_19735	COG1802	Transcriptional regulator
LI89_19735	COG4626	Terminase
LI89_19835	COG0582	viral genome integration into host DNA
LI89_19840	COG0745	RESPONSE REGULATOR receiver
LI89_19840	COG3706	GGDEF domain
LI89_19845	COG3133	Outer membrane lipoprotein
LI89_19850	COG1278	Cold shock
LI89_19855	COG1278	Cold shock
LI89_19860	COG1278	Cold shock
LI89_19865	COG0471	metal ion transport
LI89_19870	COG1560	Kdo2-lipid A biosynthetic process
LI89_19880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_19885	COG4597	amino acid ABC transporter
LI89_19890	COG0765	amino acid transport
LI89_19895	COG1126	abc transporter atp-binding protein
LI89_19905	COG1380	Effector of murein hydrolase LrgA
LI89_19910	COG0583	DNA-binding transcription factor activity
LI89_19915	COG0025	NhaP-type Na H and K H
LI89_19920	COG2252	PERMEase
LI89_19935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LI89_19940	COG2315	Protein conserved in bacteria
LI89_19945	COG1448	Aminotransferase
LI89_19950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LI89_19955	COG0305	Participates in initiation and elongation during chromosome replication
LI89_19975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LI89_19980	COG0735	belongs to the Fur family
LI89_19985	COG3237	CsbD-like
LI89_19990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LI89_19995	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LI89_20000	COG2937	Belongs to the GPAT DAPAT family
LI89_20005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LI89_20010	COG3161	chorismate lyase activity
LI89_20020	COG4580	involved in the transport of maltose and maltodextrins
LI89_20030	COG2182	Extracellular solute-binding protein
LI89_20035	COG1175	transmembrane transport
LI89_20040	COG3833	ABC-type maltose transport systems, permease component
LI89_20045	COG3223	Belongs to the PsiE family
LI89_20050	COG0166	Belongs to the GPI family
LI89_20055	COG0527	aspartate kinase activity
LI89_20080	COG1414	Transcriptional regulator
LI89_20085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LI89_20095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LI89_20100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LI89_20130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LI89_20135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LI89_20140	COG0009	L-threonylcarbamoyladenylate synthase
LI89_20145	COG0551	DNA topoisomerase type I activity
LI89_20155	COG0758	DNA mediated transformation
LI89_20160	COG0242	peptide deformylase activity
LI89_20165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LI89_20170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LI89_20170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LI89_20175	COG0569	domain protein
LI89_20180	COG1970	mechanosensitive ion channel activity
LI89_20185	COG3036	rescue of stalled ribosome
LI89_20190	COG0789	Transcriptional regulator
LI89_20200	COG0203	ribosomal protein L17
LI89_20205	COG0202	RNA polymerase activity
LI89_20210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LI89_20215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LI89_20220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LI89_20225	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LI89_20230	COG0201	protein transport
LI89_20235	COG0200	Binds to the 23S rRNA
LI89_20240	COG1841	ribosomal large subunit assembly
LI89_20250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LI89_20255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LI89_20265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LI89_20270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LI89_20275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LI89_20280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LI89_20285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LI89_20290	COG0255	Belongs to the universal ribosomal protein uL29 family
LI89_20295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LI89_20300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LI89_20305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LI89_20310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LI89_20315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LI89_20320	COG0089	rRNA binding
LI89_20325	COG0088	Forms part of the polypeptide exit tunnel
LI89_20330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LI89_20335	COG0051	transcription antitermination factor activity, RNA binding
LI89_20350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LI89_20360	COG0049	tRNA binding
LI89_20365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LI89_20370	COG2168	tRNA wobble position uridine thiolation
LI89_20375	COG2923	Belongs to the DsrF TusC family
LI89_20380	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LI89_20385	COG2964	Protein conserved in bacteria
LI89_20390	COG0545	Peptidyl-prolyl cis-trans isomerase
LI89_20395	COG2900	Belongs to the SlyX family
LI89_20400	COG1047	Peptidyl-prolyl cis-trans
LI89_20405	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LI89_20415	COG2249	NAD(P)H dehydrogenase (quinone) activity
LI89_20420	COG0488	(ABC) transporter
LI89_20425	COG1216	Glycosyl transferase, family 2
LI89_20435	COG2175	clavaminate synthase activity
LI89_20440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LI89_20450	COG4521	taurine ABC transporter
LI89_20465	COG0429	hydrolase of the alpha beta-hydrolase fold
LI89_20470	COG3089	Belongs to the UPF0270 family
LI89_20475	COG3954	Phosphoribulokinase
LI89_20480	COG1765	OsmC-like protein
LI89_20490	COG1289	transmembrane transporter activity
LI89_20505	COG0433	COG0433 Predicted ATPase
LI89_20510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LI89_20515	COG1486	melibiose metabolic process
LI89_20525	COG0738	Major facilitator superfamily
LI89_20530	COG0402	S-adenosylhomocysteine deaminase activity
LI89_20535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LI89_20540	COG2146	nitrite reductase [NAD(P)H] activity
LI89_20550	COG1648	precorrin-2 dehydrogenase activity
LI89_20550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_20555	COG0180	Tryptophanyl-tRNA synthetase
LI89_20565	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LI89_20585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LI89_20590	COG4796	Type ii and iii secretion system protein
LI89_20615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LI89_20620	COG0494	nUDIX hydrolase
LI89_20630	COG1011	Hydrolase
LI89_20635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LI89_20645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LI89_20655	COG0745	RESPONSE REGULATOR receiver
LI89_20660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LI89_20665	COG2183	response to ionizing radiation
LI89_20670	COG1918	ferrous iron import across plasma membrane
LI89_20675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LI89_20690	COG0596	Alpha beta hydrolase
LI89_20700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LI89_20700	COG0316	Belongs to the HesB IscA family
LI89_20705	COG1640	4-alpha-glucanotransferase
LI89_20710	COG0058	SHG alpha-glucan phosphorylase activity
LI89_20715	COG2909	trisaccharide binding
LI89_20730	COG0705	Rhomboid family
LI89_20735	COG1349	DNA-binding transcription factor activity
LI89_20745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LI89_20750	COG0058	SHG alpha-glucan phosphorylase activity
LI89_20755	COG0297	glycogen (starch) synthase activity
LI89_20765	COG1523	belongs to the glycosyl hydrolase 13 family
LI89_20770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LI89_20775	COG3275	phosphorelay sensor kinase activity
LI89_20795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LI89_20800	COG2095	MarC family integral membrane protein
LI89_20805	COG3265	gluconokinase activity
LI89_20810	COG2610	gluconate transmembrane transporter activity
LI89_20815	COG1609	Transcriptional regulator
LI89_20820	COG1741	Belongs to the pirin family
LI89_20825	COG1247	-acetyltransferase
LI89_20830	COG1082	Xylose isomerase domain protein TIM barrel
LI89_20835	COG0673	inositol 2-dehydrogenase activity
LI89_20845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_20855	COG3718	enzyme involved in inositol metabolism
LI89_20870	COG2814	Major facilitator Superfamily
LI89_20875	COG0583	DNA-binding transcription factor activity
LI89_20885	COG0561	phosphatase activity
LI89_20895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_20895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LI89_20900	COG0583	DNA-binding transcription factor activity
LI89_20910	COG1648	precorrin-2 dehydrogenase activity
LI89_20910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LI89_20920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LI89_20930	COG4865	methylaspartate mutase activity
LI89_20935	COG3799	methylaspartate ammonia-lyase activity
LI89_20950	COG1301	dicarboxylic acid transport
LI89_20955	COG2081	HI0933 family
LI89_20960	COG0306	phosphate transporter
LI89_20970	COG0589	response to stress
LI89_20985	COG0742	ribosomal rna small subunit methyltransferase
LI89_20995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LI89_21000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LI89_21050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_21120	COG1295	ribonuclease BN
LI89_21125	COG2134	cdp-diacylglycerol pyrophosphatase
LI89_21130	COG2982	Protein involved in outer membrane biogenesis
LI89_21135	COG2200	EAL domain
LI89_21140	COG1942	4-Oxalocrotonate Tautomerase
LI89_21145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LI89_21150	COG0612	Peptidase, M16
LI89_21155	COG1301	dicarboxylic acid transport
LI89_21170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LI89_21175	COG2199	diguanylate cyclase activity
LI89_21175	COG2200	EAL domain
LI89_21180	COG3118	belongs to the thioredoxin family
LI89_21180	COG0457	Tetratricopeptide repeat
LI89_21185	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LI89_21190	COG1215	transferase activity, transferring glycosyl groups
LI89_21205	COG1192	Involved in chromosome partitioning
LI89_21225	COG2194	sulfuric ester hydrolase activity
LI89_21230	COG4608	Belongs to the ABC transporter superfamily
LI89_21235	COG0444	Belongs to the ABC transporter superfamily
LI89_21240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LI89_21245	COG0601	transmembrane transport
LI89_21250	COG0747	negative chemotaxis
LI89_21255	COG3210	domain, Protein
LI89_21260	COG2831	hemolysin activation secretion protein
LI89_21265	COG3210	domain, Protein
LI89_21275	COG2271	Major facilitator Superfamily
LI89_21280	COG3851	Histidine kinase
LI89_21285	COG2197	response regulator
LI89_21290	COG2194	sulfuric ester hydrolase activity
LI89_21295	COG1764	response to oxidative stress
LI89_21310	COG2986	histidine ammonia-lyase
LI89_21315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LI89_21355	COG1482	cell wall glycoprotein biosynthetic process
LI89_21360	COG2723	6-phospho-beta-galactosidase activity
LI89_21375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_21380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_21385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LI89_21390	COG1447	Phosphotransferase system cellobiose-specific component IIA
LI89_21395	COG1940	carbohydrate kinase activity
LI89_21400	COG1609	Transcriptional regulator
LI89_21455	COG0582	viral genome integration into host DNA
LI89_21460	COG2207	Transcriptional regulator
LI89_21460	COG1609	Transcriptional regulator
LI89_21465	COG4214	carbohydrate transport
LI89_21475	COG4213	ABC transporter substrate-binding protein
LI89_21480	COG2115	Belongs to the xylose isomerase family
LI89_21485	COG1070	Carbohydrate kinase
LI89_21490	COG3121	Chaperone
LI89_21510	COG3274	enterobacterial common antigen metabolic process
LI89_21520	COG3276	selenocysteine insertion sequence binding
LI89_21525	COG1921	L-seryl-tRNASec selenium transferase activity
LI89_21530	COG3058	Necessary for formate dehydrogenase activity
LI89_21535	COG2864	formate dehydrogenase
LI89_21540	COG0437	4 iron, 4 sulfur cluster binding
LI89_21545	COG3383	formate dehydrogenase (NAD+) activity
LI89_21545	COG0243	molybdopterin cofactor binding
LI89_21550	COG3383	formate dehydrogenase (NAD+) activity
LI89_21550	COG0243	molybdopterin cofactor binding
LI89_21555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LI89_21560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LI89_21565	COG0840	transmembrane signaling receptor activity
LI89_21570	COG2258	MOSC domain
LI89_21590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LI89_21600	COG3722	fumarate hydratase activity
LI89_21605	COG0246	Mannitol dehydrogenase
LI89_21610	COG2213	PTS system mannitol-specific
LI89_21610	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LI89_21620	COG0751	glycine-tRNA ligase activity
LI89_21625	COG0752	glycyl-tRNA synthetase alpha subunit
LI89_21630	COG2818	Glycosylase
LI89_21650	COG2885	chlorophyll binding
LI89_21665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LI89_21670	COG0366	Alpha amylase catalytic
LI89_21675	COG3977	Valine--pyruvate aminotransferase
LI89_21680	COG0569	domain protein
LI89_21680	COG2985	domain, Protein
LI89_21695	COG5645	(Lipo)protein
LI89_21700	COG0823	Involved in the tonB-independent uptake of proteins
LI89_21705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LI89_21710	COG2423	ornithine cyclodeaminase activity
LI89_21715	COG1940	carbohydrate kinase activity
LI89_21720	COG0561	phosphatase activity
LI89_21725	COG0187	DNA topoisomerase II activity
LI89_21730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LI89_21735	COG0592	DNA-directed DNA polymerase activity
LI89_21740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LI89_21745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LI89_21750	COG0594	ribonuclease P activity
LI89_21755	COG0706	membrane insertase activity
LI89_21760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LI89_21765	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LI89_21780	COG2011	ABC-type metal ion transport system permease component
LI89_21785	COG0840	transmembrane signaling receptor activity
LI89_21790	COG0431	NADPH-dependent FMN reductase
LI89_21795	COG4191	Histidine kinase
LI89_21810	COG2252	PERMEase
LI89_21815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LI89_21820	COG0765	amino acid transport
LI89_21825	COG0765	amino acid transport
LI89_21830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LI89_21840	COG0704	Plays a role in the regulation of phosphate uptake
LI89_21850	COG0581	inorganic phosphate transmembrane transporter activity
LI89_21855	COG0573	inorganic phosphate transmembrane transporter activity
LI89_21860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LI89_21865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LI89_21870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LI89_21875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LI89_21880	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LI89_21885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LI89_21890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LI89_21895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LI89_21900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LI89_21910	COG0356	it plays a direct role in the translocation of protons across the membrane
LI89_21915	COG3312	ion transport
LI89_21920	COG0357	Ribosomal RNA small subunit methyltransferase G
LI89_21925	COG0445	tRNA wobble uridine modification
LI89_21960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LI89_22245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LI89_22250	COG3715	PTS system
LI89_22255	COG3716	PTS system mannose fructose sorbose family IID component
LI89_22280	COG5492	domain, Protein
LI89_22430	COG3547	Transposase (IS116 IS110 IS902 family)
LI89_22440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family