locus-tag	class	description
FORC065_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC065_0002	COG0592	DNA-directed DNA polymerase activity
FORC065_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC065_0006	COG0561	phosphatase activity
FORC065_0007	COG2423	ornithine cyclodeaminase activity
FORC065_0009	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORC065_0011	COG5645	(Lipo)protein
FORC065_0014	COG0569	domain protein
FORC065_0014	COG2985	domain, Protein
FORC065_0015	COG3977	Valine--pyruvate aminotransferase
FORC065_0016	COG0366	Alpha amylase catalytic
FORC065_0017	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC065_0020	COG2885	chlorophyll binding
FORC065_0025	COG2818	Glycosylase
FORC065_0026	COG0752	glycyl-tRNA synthetase alpha subunit
FORC065_0027	COG0751	glycine-tRNA ligase activity
FORC065_0031	COG2213	PTS system mannitol-specific
FORC065_0031	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_0032	COG0246	Mannitol dehydrogenase
FORC065_0033	COG3722	fumarate hydratase activity
FORC065_0038	COG2258	MOSC domain
FORC065_0039	COG0840	transmembrane signaling receptor activity
FORC065_0040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FORC065_0041	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC065_0042	COG0243	molybdopterin cofactor binding
FORC065_0042	COG3383	formate dehydrogenase (NAD+) activity
FORC065_0043	COG3383	formate dehydrogenase (NAD+) activity
FORC065_0043	COG0243	molybdopterin cofactor binding
FORC065_0044	COG0437	4 iron, 4 sulfur cluster binding
FORC065_0045	COG2864	formate dehydrogenase
FORC065_0046	COG3058	Necessary for formate dehydrogenase activity
FORC065_0047	COG1921	L-seryl-tRNASec selenium transferase activity
FORC065_0048	COG3276	selenocysteine insertion sequence binding
FORC065_0050	COG3274	enterobacterial common antigen metabolic process
FORC065_0054	COG3121	Chaperone
FORC065_0055	COG1070	Carbohydrate kinase
FORC065_0056	COG2115	Belongs to the xylose isomerase family
FORC065_0057	COG4213	ABC transporter substrate-binding protein
FORC065_0059	COG4214	carbohydrate transport
FORC065_0060	COG2207	Transcriptional regulator
FORC065_0060	COG1609	Transcriptional regulator
FORC065_0061	COG1609	Transcriptional regulator
FORC065_0061	COG2207	Transcriptional regulator
FORC065_0063	COG1609	Transcriptional regulator
FORC065_0064	COG1940	carbohydrate kinase activity
FORC065_0065	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC065_0067	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC065_0068	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC065_0071	COG2723	6-phospho-beta-galactosidase activity
FORC065_0074	COG0582	viral genome integration into host DNA
FORC065_0077	COG4974	Belongs to the 'phage' integrase family
FORC065_0080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC065_0081	COG2986	histidine ammonia-lyase
FORC065_0084	COG1764	response to oxidative stress
FORC065_0086	COG2197	response regulator
FORC065_0087	COG3851	Histidine kinase
FORC065_0088	COG2271	Major facilitator Superfamily
FORC065_0089	COG3210	domain, Protein
FORC065_0090	COG2831	hemolysin activation secretion protein
FORC065_0091	COG3210	domain, Protein
FORC065_0093	COG0747	negative chemotaxis
FORC065_0094	COG0601	transmembrane transport
FORC065_0095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC065_0096	COG0444	Belongs to the ABC transporter superfamily
FORC065_0097	COG4608	Belongs to the ABC transporter superfamily
FORC065_0098	COG2194	sulfuric ester hydrolase activity
FORC065_0102	COG1192	Involved in chromosome partitioning
FORC065_0103	COG1215	transferase activity, transferring glycosyl groups
FORC065_0104	COG1215	transferase activity, transferring glycosyl groups
FORC065_0105	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FORC065_0106	COG3118	belongs to the thioredoxin family
FORC065_0106	COG0457	Tetratricopeptide repeat
FORC065_0107	COG2199	diguanylate cyclase activity
FORC065_0107	COG2200	EAL domain
FORC065_0108	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC065_0112	COG0612	Peptidase, M16
FORC065_0113	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC065_0114	COG1942	4-Oxalocrotonate Tautomerase
FORC065_0116	COG2200	EAL domain
FORC065_0118	COG2134	cdp-diacylglycerol pyrophosphatase
FORC065_0119	COG1295	ribonuclease BN
FORC065_0122	COG1396	sequence-specific DNA binding
FORC065_0124	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC065_0125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC065_0127	COG0742	ribosomal rna small subunit methyltransferase
FORC065_0128	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FORC065_0130	COG0589	response to stress
FORC065_0133	COG0306	phosphate transporter
FORC065_0134	COG2081	HI0933 family
FORC065_0135	COG1301	dicarboxylic acid transport
FORC065_0139	COG3799	methylaspartate ammonia-lyase activity
FORC065_0140	COG4865	methylaspartate mutase activity
FORC065_0142	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC065_0145	COG1648	precorrin-2 dehydrogenase activity
FORC065_0145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC065_0147	COG0583	DNA-binding transcription factor activity
FORC065_0148	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC065_0148	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC065_0150	COG0561	phosphatase activity
FORC065_0152	COG0583	DNA-binding transcription factor activity
FORC065_0153	COG2814	Major facilitator Superfamily
FORC065_0155	COG3718	enzyme involved in inositol metabolism
FORC065_0157	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC065_0159	COG0673	inositol 2-dehydrogenase activity
FORC065_0160	COG1082	Xylose isomerase domain protein TIM barrel
FORC065_0161	COG1247	-acetyltransferase
FORC065_0162	COG1741	Belongs to the pirin family
FORC065_0163	COG1609	Transcriptional regulator
FORC065_0164	COG2610	gluconate transmembrane transporter activity
FORC065_0165	COG3265	gluconokinase activity
FORC065_0166	COG2095	MarC family integral membrane protein
FORC065_0171	COG3275	phosphorelay sensor kinase activity
FORC065_0172	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC065_0173	COG1523	belongs to the glycosyl hydrolase 13 family
FORC065_0176	COG0058	SHG alpha-glucan phosphorylase activity
FORC065_0177	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC065_0179	COG1349	DNA-binding transcription factor activity
FORC065_0180	COG0705	Rhomboid family
FORC065_0185	COG2909	trisaccharide binding
FORC065_0187	COG1640	4-alpha-glucanotransferase
FORC065_0188	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC065_0188	COG0316	Belongs to the HesB IscA family
FORC065_0190	COG0596	Alpha beta hydrolase
FORC065_0194	COG1918	ferrous iron import across plasma membrane
FORC065_0195	COG2183	response to ionizing radiation
FORC065_0196	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC065_0199	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC065_0201	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC065_0202	COG1011	Hydrolase
FORC065_0205	COG0494	nUDIX hydrolase
FORC065_0206	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC065_0212	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC065_0216	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC065_0218	COG0180	Tryptophanyl-tRNA synthetase
FORC065_0219	COG1648	precorrin-2 dehydrogenase activity
FORC065_0219	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC065_0222	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC065_0224	COG0402	S-adenosylhomocysteine deaminase activity
FORC065_0225	COG0738	Major facilitator superfamily
FORC065_0227	COG1486	melibiose metabolic process
FORC065_0228	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC065_0229	COG0433	COG0433 Predicted ATPase
FORC065_0232	COG1289	transmembrane transporter activity
FORC065_0234	COG1765	OsmC-like protein
FORC065_0235	COG3954	Phosphoribulokinase
FORC065_0236	COG3089	Belongs to the UPF0270 family
FORC065_0237	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC065_0241	COG4521	taurine ABC transporter
FORC065_0243	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC065_0244	COG2175	clavaminate synthase activity
FORC065_0246	COG1216	Glycosyl transferase, family 2
FORC065_0247	COG0488	(ABC) transporter
FORC065_0248	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC065_0250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FORC065_0251	COG1047	Peptidyl-prolyl cis-trans
FORC065_0252	COG2900	Belongs to the SlyX family
FORC065_0253	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC065_0254	COG2964	Protein conserved in bacteria
FORC065_0255	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC065_0256	COG2923	Belongs to the DsrF TusC family
FORC065_0257	COG2168	tRNA wobble position uridine thiolation
FORC065_0258	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FORC065_0259	COG0049	tRNA binding
FORC065_0261	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC065_0264	COG0051	transcription antitermination factor activity, RNA binding
FORC065_0265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC065_0266	COG0088	Forms part of the polypeptide exit tunnel
FORC065_0267	COG0089	rRNA binding
FORC065_0268	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC065_0269	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC065_0270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC065_0271	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC065_0272	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FORC065_0273	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC065_0274	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC065_0275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC065_0276	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC065_0277	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC065_0278	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC065_0280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC065_0281	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FORC065_0283	COG1841	ribosomal large subunit assembly
FORC065_0284	COG0200	Binds to the 23S rRNA
FORC065_0285	COG0201	protein transport
FORC065_0286	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC065_0287	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC065_0288	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FORC065_0289	COG0202	RNA polymerase activity
FORC065_0290	COG0203	ribosomal protein L17
FORC065_0292	COG0789	Transcriptional regulator
FORC065_0293	COG3036	rescue of stalled ribosome
FORC065_0294	COG1970	mechanosensitive ion channel activity
FORC065_0296	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC065_0296	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC065_0298	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC065_0299	COG0242	peptide deformylase activity
FORC065_0300	COG0758	DNA mediated transformation
FORC065_0302	COG0551	DNA topoisomerase type I activity
FORC065_0303	COG0009	L-threonylcarbamoyladenylate synthase
FORC065_0305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC065_0308	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC065_0309	COG3162	membrane
FORC065_0310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC065_0311	COG1301	dicarboxylic acid transport
FORC065_0312	COG2197	response regulator
FORC065_0345	COG2391	methyltransferase activity
FORC065_0346	COG0425	Belongs to the sulfur carrier protein TusA family
FORC065_0347	COG3093	addiction module antidote protein HigA
FORC065_0353	COG3712	iron ion homeostasis
FORC065_0354	COG4771	TonB-dependent receptor
FORC065_0355	COG4178	(ABC) transporter
FORC065_0356	COG0612	Peptidase, M16
FORC065_0357	COG1511	domain protein
FORC065_0357	COG3264	Mechanosensitive ion channel
FORC065_0358	COG4774	siderophore transport
FORC065_0360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC065_0361	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC065_0362	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC065_0363	COG4558	Periplasmic binding protein
FORC065_0364	COG3720	iron ion transport
FORC065_0367	COG0702	epimerase
FORC065_0368	COG3721	Heme iron utilization protein
FORC065_0371	COG0814	amino acid
FORC065_0373	COG1882	Formate acetyltransferase
FORC065_0375	COG1929	Belongs to the glycerate kinase type-1 family
FORC065_0376	COG4232	protein-disulfide reductase activity
FORC065_0378	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC065_0382	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC065_0387	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC065_0391	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC065_0392	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC065_0393	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC065_0394	COG1053	succinate dehydrogenase
FORC065_0395	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC065_0396	COG1511	domain protein
FORC065_0396	COG3264	Mechanosensitive ion channel
FORC065_0397	COG0688	phosphatidylethanolamine metabolic process
FORC065_0398	COG1162	GTPase activity
FORC065_0399	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC065_0400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC065_0401	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC065_0401	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC065_0402	COG0802	atpase or kinase
FORC065_0403	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC065_0404	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC065_0405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC065_0406	COG1923	regulation of RNA biosynthetic process
FORC065_0407	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC065_0408	COG0330	HflC and HflK could
FORC065_0409	COG0330	HflC and HflK could
FORC065_0410	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC065_0411	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC065_0412	COG1959	2 iron, 2 sulfur cluster binding
FORC065_0413	COG0557	exoribonuclease II activity
FORC065_0414	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC065_0416	COG1960	acyl-CoA dehydrogenase activity
FORC065_0417	COG3650	response to hydrogen peroxide
FORC065_0418	COG1073	alpha beta
FORC065_0420	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC065_0421	COG2965	DNA replication, synthesis of RNA primer
FORC065_0422	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FORC065_0423	COG0359	binds to the 23S rRNA
FORC065_0425	COG3061	Opacity-associated protein A
FORC065_0427	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC065_0429	COG0737	Belongs to the 5'-nucleotidase family
FORC065_0430	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC065_0431	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC065_0433	COG1253	flavin adenine dinucleotide binding
FORC065_0434	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC065_0439	COG2105	PFAM AIG2 family protein
FORC065_0440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC065_0443	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC065_0444	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC065_0446	COG1438	arginine binding
FORC065_0447	COG0039	L-malate dehydrogenase activity
FORC065_0449	COG3423	Transcriptional regulator
FORC065_0451	COG0142	geranyltranstransferase activity
FORC065_0452	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC065_0453	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FORC065_0454	COG0697	spore germination
FORC065_0455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC065_0456	COG0642	Histidine kinase
FORC065_0457	COG0745	RESPONSE REGULATOR receiver
FORC065_0458	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC065_0460	COG1534	Rna-binding protein
FORC065_0461	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC065_0463	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC065_0464	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC065_0465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC065_0466	COG0779	Required for maturation of 30S ribosomal subunits
FORC065_0467	COG0195	Participates in both transcription termination and antitermination
FORC065_0468	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC065_0469	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC065_0470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC065_0471	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC065_0472	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC065_0474	COG0513	Belongs to the DEAD box helicase family
FORC065_0477	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC065_0478	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_0481	COG0814	amino acid
FORC065_0483	COG0826	peptidase U32
FORC065_0484	COG0826	peptidase U32
FORC065_0485	COG3154	lipid carrier protein
FORC065_0486	COG3153	acetyltransferase
FORC065_0487	COG2827	Endonuclease containing a URI domain
FORC065_0488	COG0531	amino acid
FORC065_0489	COG1982	Orn Lys Arg decarboxylase major
FORC065_0492	COG1653	transport
FORC065_0493	COG1175	transmembrane transport
FORC065_0494	COG0395	ABC-type sugar transport system, permease component
FORC065_0495	COG3842	ATPase activity
FORC065_0497	COG3787	Belongs to the UPF0306 family
FORC065_0499	COG0702	epimerase
FORC065_0500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FORC065_0501	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FORC065_0502	COG3454	Phosphonate metabolism
FORC065_0503	COG4778	phosphonate C-P lyase system protein PhnL
FORC065_0504	COG4107	phosphonate C-P lyase system protein PhnK
FORC065_0505	COG3627	carbon phosphorus lyase activity
FORC065_0506	COG3626	phosphonate metabolism
FORC065_0508	COG3624	Phosphonate C-P lyase system protein PhnG
FORC065_0509	COG2188	Transcriptional regulator
FORC065_0514	COG0583	DNA-binding transcription factor activity
FORC065_0515	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC065_0518	COG4608	Belongs to the ABC transporter superfamily
FORC065_0519	COG0444	Belongs to the ABC transporter superfamily
FORC065_0520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC065_0521	COG0601	transmembrane transport
FORC065_0523	COG2731	YhcH YjgK YiaL family protein
FORC065_0525	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FORC065_0528	COG2927	DNA polymerase III (CHI subunit)
FORC065_0529	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC065_0530	COG0795	lipopolysaccharide-transporting ATPase activity
FORC065_0531	COG0795	lipopolysaccharide-transporting ATPase activity
FORC065_0532	COG0582	viral genome integration into host DNA
FORC065_0544	COG1401	restriction endodeoxyribonuclease activity
FORC065_0571	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC065_0572	COG1830	Aldolase
FORC065_0573	COG1879	ABC-type sugar transport system periplasmic component
FORC065_0574	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_0575	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_0577	COG2390	Transcriptional regulator
FORC065_0579	COG1070	Carbohydrate kinase
FORC065_0581	COG0859	PFAM glycosyl transferase family 9
FORC065_0585	COG2235	arginine
FORC065_0587	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_0588	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC065_0597	COG2376	Dihydroxyacetone kinase
FORC065_0598	COG1461	Dihydroxyacetone kinase
FORC065_0602	COG2192	nodulation
FORC065_0608	COG3284	Transcriptional regulator
FORC065_0617	COG4772	TonB-dependent receptor
FORC065_0624	COG0667	Aldo Keto reductase
FORC065_0625	COG2813	Specifically methylates the guanine in position
FORC065_0626	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FORC065_0627	COG0456	acetyltransferase
FORC065_0628	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC065_0629	COG2823	Periplasmic or secreted lipoprotein
FORC065_0631	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC065_0632	COG0084	hydrolase, TatD family'
FORC065_0633	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC065_0635	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC065_0636	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC065_0637	COG0813	purine-nucleoside phosphorylase activity
FORC065_0638	COG3726	membrane protein affecting hemolysin expression
FORC065_0639	COG0560	Phosphoserine phosphatase
FORC065_0644	COG0488	(ABC) transporter
FORC065_0645	COG2885	chlorophyll binding
FORC065_0646	COG2199	diguanylate cyclase activity
FORC065_0648	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FORC065_0650	COG0741	lytic transglycosylase activity
FORC065_0651	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC065_0652	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC065_0653	COG0406	alpha-ribazole phosphatase activity
FORC065_0654	COG3708	Transcriptional regulator
FORC065_0654	COG2207	Transcriptional regulator
FORC065_0655	COG3045	CreA protein
FORC065_0656	COG0745	RESPONSE REGULATOR receiver
FORC065_0659	COG0083	homoserine kinase activity
FORC065_0661	COG3022	response to hydroperoxide
FORC065_0662	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC065_0663	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC065_0666	COG1584	GPR1 FUN34 yaaH family protein
FORC065_0668	COG0484	heat shock protein binding
FORC065_0669	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC065_0671	COG0268	Binds directly to 16S ribosomal RNA
FORC065_0672	COG0196	riboflavin kinase activity
FORC065_0673	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC065_0674	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC065_0675	COG1047	Peptidyl-prolyl cis-trans
FORC065_0676	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC065_0677	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC065_0679	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC065_0680	COG1280	lysine exporter protein (LysE YggA)
FORC065_0682	COG2966	Psort location CytoplasmicMembrane, score
FORC065_0684	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC065_0685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC065_0686	COG2967	ApaG domain
FORC065_0688	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC065_0689	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC065_0691	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC065_0692	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC065_0693	COG0564	pseudouridine synthase activity
FORC065_0694	COG1388	LysM domain
FORC065_0694	COG2373	Large extracellular alpha-helical protein
FORC065_0694	COG4932	domain protein
FORC065_0696	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC065_0698	COG0417	DNA replication proofreading
FORC065_0699	COG0586	Pfam SNARE associated Golgi protein
FORC065_0701	COG1178	ABC-type Fe3 transport system permease component
FORC065_0702	COG4143	(ABC) transporter
FORC065_0705	COG4533	DNA binding
FORC065_0706	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC065_0707	COG1882	Formate acetyltransferase
FORC065_0709	COG2814	Major facilitator Superfamily
FORC065_0710	COG0814	amino acid
FORC065_0711	COG3033	Beta-eliminating lyase
FORC065_0714	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC065_0715	COG0473	3-isopropylmalate dehydrogenase activity
FORC065_0716	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC065_0718	COG1022	Amp-dependent synthetase and ligase
FORC065_0720	COG0028	Belongs to the TPP enzyme family
FORC065_0724	COG2001	Belongs to the MraZ family
FORC065_0725	COG0275	rRNA processing
FORC065_0726	COG3116	cell division
FORC065_0727	COG0768	penicillin binding
FORC065_0728	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC065_0729	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC065_0730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC065_0733	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC065_0734	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC065_0736	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC065_0737	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC065_0738	COG0849	cell division
FORC065_0739	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC065_0743	COG0653	protein targeting
FORC065_0744	COG0494	nUDIX hydrolase
FORC065_0745	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC065_0746	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC065_0748	COG0516	GMP reductase activity
FORC065_0750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC065_0751	COG4969	Belongs to the N-Me-Phe pilin family
FORC065_0754	COG3725	Membrane protein required for beta-lactamase induction
FORC065_0755	COG1113	amino acid transport
FORC065_0757	COG2186	Transcriptional regulator
FORC065_0758	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC065_0759	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC065_0760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC065_0765	COG3112	Uncharacterised protein family (UPF0231)
FORC065_0766	COG0697	spore germination
FORC065_0768	COG3210	domain, Protein
FORC065_0770	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FORC065_0774	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FORC065_0775	COG0288	reversible hydration of carbon dioxide
FORC065_0776	COG1131	(ABC) transporter
FORC065_0777	COG0842	Transport permease protein
FORC065_0779	COG0726	polysaccharide deacetylase
FORC065_0780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FORC065_0781	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC065_0782	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC065_0783	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC065_0787	COG1489	DNA binding
FORC065_0788	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FORC065_0789	COG1643	Atp-dependent helicase
FORC065_0791	COG1120	ATPase activity
FORC065_0792	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC065_0794	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC065_0797	COG0316	Belongs to the HesB IscA family
FORC065_0799	COG2860	membrane
FORC065_0801	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC065_0802	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC065_0804	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC065_0805	COG3850	Histidine kinase
FORC065_0805	COG4999	Histidine kinase
FORC065_0805	COG2205	protein histidine kinase activity
FORC065_0805	COG3437	response regulator, receiver
FORC065_0806	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC065_0807	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC065_0808	COG3956	TIGRFAM MazG family protein
FORC065_0809	COG0504	CTP synthase activity
FORC065_0810	COG0148	phosphopyruvate hydratase activity
FORC065_0815	COG0602	queuosine metabolic process
FORC065_0816	COG0720	synthase
FORC065_0817	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC065_0818	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC065_0819	COG0175	sulfate reduction
FORC065_0822	COG2234	aminopeptidase activity
FORC065_0823	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC065_0823	COG1648	precorrin-2 dehydrogenase activity
FORC065_0824	COG0175	sulfate reduction
FORC065_0825	COG2895	sulfate adenylyltransferase (ATP) activity
FORC065_0826	COG0529	Catalyzes the synthesis of activated sulfate
FORC065_0829	COG0765	amino acid transport
FORC065_0831	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC065_0833	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC065_0834	COG0585	pseudouridine synthase activity
FORC065_0835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC065_0836	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC065_0837	COG1388	LysM domain
FORC065_0837	COG4942	peptidase
FORC065_0838	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC065_0839	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC065_0846	COG3188	usher protein
FORC065_0847	COG3121	Chaperone
FORC065_0849	COG3539	Fimbrial protein
FORC065_0850	COG3539	Fimbrial protein
FORC065_0855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_0857	COG1538	Outer membrane efflux protein
FORC065_0861	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_0863	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC065_0864	COG1858	cytochrome C peroxidase
FORC065_0865	COG0583	DNA-binding transcription factor activity
FORC065_0866	COG2610	gluconate transmembrane transporter activity
FORC065_0867	COG3048	D-serine ammonia-lyase activity
FORC065_0868	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_0869	COG0765	amino acid transport
FORC065_0870	COG0765	amino acid transport
FORC065_0871	COG1126	abc transporter atp-binding protein
FORC065_0872	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC065_0873	COG3665	Urea carboxylase-associated protein
FORC065_0877	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC065_0878	COG0640	Transcriptional regulator
FORC065_0889	COG0410	ABC transporter
FORC065_0890	COG1137	ATPase activity
FORC065_0891	COG4177	L-phenylalanine transmembrane transporter activity
FORC065_0894	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC065_0894	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC065_0895	COG1070	Carbohydrate kinase
FORC065_0896	COG3623	hexulose-6-phosphate isomerase
FORC065_0898	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_0899	COG1129	ABC transporter
FORC065_0901	COG1349	DNA-binding transcription factor activity
FORC065_0904	COG1349	DNA-binding transcription factor activity
FORC065_0906	COG1070	Carbohydrate kinase
FORC065_0908	COG0738	Major facilitator superfamily
FORC065_0909	COG0235	Class ii aldolase
FORC065_0910	COG1454	alcohol dehydrogenase
FORC065_0912	COG0437	4 iron, 4 sulfur cluster binding
FORC065_0913	COG3302	dmso reductase anchor subunit
FORC065_0914	COG3381	protein complex oligomerization
FORC065_0917	COG1879	ABC-type sugar transport system periplasmic component
FORC065_0919	COG1129	ABC transporter
FORC065_0920	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_0921	COG3959	Transketolase, thiamine diphosphate binding domain
FORC065_0922	COG3959	Transketolase, thiamine diphosphate binding domain
FORC065_0923	COG3958	Transketolase
FORC065_0924	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC065_0929	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC065_0930	COG2137	regulation of response to DNA damage stimulus
FORC065_0931	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC065_0932	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FORC065_0933	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC065_0934	COG1238	metal cluster binding
FORC065_0935	COG2918	glutathione biosynthetic process
FORC065_0936	COG1854	S-ribosylhomocysteine lyase activity
FORC065_0937	COG4536	flavin adenine dinucleotide binding
FORC065_0938	COG4137	Cytochrome C assembly protein
FORC065_0939	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC065_0940	COG0228	four-way junction DNA binding
FORC065_0941	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC065_0942	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC065_0943	COG0335	large ribosomal subunit rRNA binding
FORC065_0944	COG3137	Salt-induced outer membrane protein
FORC065_0948	COG3279	Response regulator of the LytR AlgR family
FORC065_0949	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC065_0950	COG0287	Prephenate dehydrogenase
FORC065_0950	COG1605	Chorismate mutase
FORC065_0951	COG0077	Prephenate dehydratase
FORC065_0951	COG1605	Chorismate mutase
FORC065_0952	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC065_0953	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC065_0954	COG0564	pseudouridine synthase activity
FORC065_0955	COG1496	oxidoreductase activity
FORC065_0956	COG0542	response to heat
FORC065_0957	COG5544	Lipoprotein
FORC065_0960	COG3148	PFAM DTW domain containing protein
FORC065_0961	COG3118	belongs to the thioredoxin family
FORC065_0962	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC065_0963	COG2814	Major facilitator Superfamily
FORC065_0964	COG1566	PFAM secretion protein HlyD family protein
FORC065_0965	COG1538	Outer membrane efflux protein
FORC065_0967	COG1846	Transcriptional regulator
FORC065_0969	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FORC065_0970	COG2814	Major facilitator Superfamily
FORC065_0978	COG0765	amino acid transport
FORC065_0979	COG0765	amino acid transport
FORC065_0981	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC065_0984	COG0436	Aminotransferase
FORC065_0985	COG0235	Class ii aldolase
FORC065_0986	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FORC065_0987	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FORC065_0988	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FORC065_0993	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
FORC065_0994	COG1960	acyl-CoA dehydrogenase activity
FORC065_0995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC065_0996	COG0121	glutamine amidotransferase
FORC065_0997	COG3034	peptidoglycan biosynthetic process
FORC065_0998	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC065_1000	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC065_1001	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC065_1002	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC065_1003	COG2871	sodium ion transport
FORC065_1004	COG1477	protein flavinylation
FORC065_1005	COG2991	Protein conserved in bacteria
FORC065_1009	COG2964	Protein conserved in bacteria
FORC065_1012	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC065_1013	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC065_1014	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC065_1015	COG1073	alpha beta
FORC065_1017	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC065_1018	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC065_1019	COG2188	Transcriptional regulator
FORC065_1024	COG3459	Glycosyltransferase 36 associated
FORC065_1027	COG2226	methyltransferase
FORC065_1033	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC065_1035	COG3123	guanosine phosphorylase activity
FORC065_1036	COG2974	May be involved in recombination
FORC065_1037	COG1940	carbohydrate kinase activity
FORC065_1038	COG0419	ATPase involved in DNA repair
FORC065_1040	COG0745	RESPONSE REGULATOR receiver
FORC065_1041	COG5002	protein histidine kinase activity
FORC065_1045	COG0366	Alpha amylase catalytic
FORC065_1048	COG0450	alkyl hydroperoxide reductase
FORC065_1049	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC065_1050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC065_1052	COG0343	queuine tRNA-ribosyltransferase activity
FORC065_1053	COG1862	Preprotein translocase
FORC065_1054	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC065_1055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC065_1056	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC065_1058	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC065_1059	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC065_1059	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC065_1061	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC065_1062	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC065_1063	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC065_1064	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC065_1065	COG0142	geranyltranstransferase activity
FORC065_1066	COG1722	exodeoxyribonuclease VII activity
FORC065_1067	COG0301	tRNA thio-modification
FORC065_1067	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC065_1069	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC065_1070	COG1666	GTP binding
FORC065_1071	COG2814	Major facilitator Superfamily
FORC065_1072	COG0109	protoheme IX farnesyltransferase activity
FORC065_1073	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC065_1074	COG1845	cytochrome c oxidase, subunit III
FORC065_1075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC065_1076	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC065_1079	COG2223	nitrite transmembrane transporter activity
FORC065_1080	COG3056	Lipoprotein
FORC065_1081	COG0271	Belongs to the BolA IbaG family
FORC065_1082	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC065_1084	COG0740	serine-type endopeptidase activity
FORC065_1085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC065_1087	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC065_1088	COG0776	regulation of translation
FORC065_1089	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC065_1090	COG1555	photosystem II stabilization
FORC065_1091	COG0824	Thioesterase
FORC065_1092	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC065_1094	COG0561	phosphatase activity
FORC065_1096	COG1522	sequence-specific DNA binding
FORC065_1097	COG1132	(ABC) transporter
FORC065_1098	COG1132	(ABC) transporter
FORC065_1099	COG1132	(ABC) transporter
FORC065_1100	COG0347	Belongs to the P(II) protein family
FORC065_1101	COG0004	ammonium transporteR
FORC065_1102	COG1946	Acyl-CoA thioesterase
FORC065_1104	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC065_1105	COG3695	enzyme binding
FORC065_1112	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC065_1114	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC065_1115	COG0254	rRNA binding
FORC065_1118	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC065_1119	COG3457	Alanine racemase
FORC065_1122	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC065_1123	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_1124	COG1309	transcriptional regulator
FORC065_1125	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC065_1129	COG2832	Protein of unknown function (DUF454)
FORC065_1131	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC065_1133	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC065_1134	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC065_1135	COG0326	Molecular chaperone. Has ATPase activity
FORC065_1136	COG0563	adenylate kinase activity
FORC065_1137	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC065_1139	COG0543	2 iron, 2 sulfur cluster binding
FORC065_1139	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC065_1145	COG0028	Belongs to the TPP enzyme family
FORC065_1146	COG0028	Belongs to the TPP enzyme family
FORC065_1151	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FORC065_1155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC065_1158	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC065_1163	COG0463	Glycosyl transferase, family 2
FORC065_1163	COG1216	Glycosyl transferase, family 2
FORC065_1165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC065_1166	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC065_1166	COG4651	solute:proton antiporter activity
FORC065_1167	COG2223	nitrite transmembrane transporter activity
FORC065_1171	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC065_1173	COG3735	TraB family
FORC065_1174	COG2217	Heavy metal translocating P-type atpase
FORC065_1175	COG0789	Transcriptional regulator
FORC065_1176	COG1585	Membrane protein implicated in regulation of membrane protease activity
FORC065_1177	COG0330	HflC and HflK could
FORC065_1178	COG3118	belongs to the thioredoxin family
FORC065_1179	COG0300	oxidoreductase activity
FORC065_1180	COG2755	lipolytic protein G-D-S-L family
FORC065_1181	COG4181	ATPase activity
FORC065_1183	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC065_1184	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC065_1185	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC065_1186	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC065_1187	COG0215	cysteine-tRNA ligase activity
FORC065_1188	COG2501	S4 domain
FORC065_1189	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC065_1190	COG0582	viral genome integration into host DNA
FORC065_1196	COG1902	pentaerythritol trinitrate reductase activity
FORC065_1199	COG0656	L-ascorbic acid biosynthetic process
FORC065_1203	COG5002	protein histidine kinase activity
FORC065_1211	COG2850	peptidyl-arginine hydroxylation
FORC065_1212	COG2986	histidine ammonia-lyase
FORC065_1215	COG5265	(ABC) transporter
FORC065_1218	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC065_1220	COG2197	response regulator
FORC065_1222	COG1278	Cold shock
FORC065_1226	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC065_1227	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC065_1228	COG0321	lipoyl(octanoyl) transferase activity
FORC065_1229	COG2921	Belongs to the UPF0250 family
FORC065_1230	COG1686	Belongs to the peptidase S11 family
FORC065_1231	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC065_1232	COG0772	Belongs to the SEDS family
FORC065_1233	COG0768	penicillin binding
FORC065_1235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC065_1236	COG0799	negative regulation of ribosome biogenesis
FORC065_1237	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC065_1238	COG1466	dna polymerase III delta subunit
FORC065_1239	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC065_1240	COG0495	leucyl-tRNA aminoacylation
FORC065_1242	COG2888	peptidyl-tyrosine sulfation
FORC065_1245	COG1126	abc transporter atp-binding protein
FORC065_1246	COG0765	amino acid transport
FORC065_1247	COG0765	amino acid transport
FORC065_1250	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC065_1251	COG4535	Mg2 and Co2 transporter CorC
FORC065_1252	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC065_1253	COG1702	phosphate starvation-inducible protein PhoH
FORC065_1254	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC065_1255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC065_1256	COG0367	asparagine synthase
FORC065_1257	COG0647	UMP catabolic process
FORC065_1260	COG1846	Transcriptional regulator
FORC065_1260	COG1940	carbohydrate kinase activity
FORC065_1261	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC065_1262	COG0363	glucosamine-6-phosphate deaminase activity
FORC065_1263	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_1263	COG2190	(PTS) system
FORC065_1263	COG1263	PTS System
FORC065_1264	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC065_1268	COG0735	belongs to the Fur family
FORC065_1270	COG0840	transmembrane signaling receptor activity
FORC065_1272	COG0596	Alpha beta hydrolase
FORC065_1274	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC065_1274	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC065_1275	COG1703	isobutyryl-CoA mutase activity
FORC065_1276	COG1024	Enoyl-CoA hydratase
FORC065_1277	COG0427	acetyl-CoA hydrolase
FORC065_1279	COG2966	Psort location CytoplasmicMembrane, score
FORC065_1281	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC065_1282	COG0033	Phosphoglucomutase
FORC065_1285	COG0745	RESPONSE REGULATOR receiver
FORC065_1287	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FORC065_1288	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FORC065_1293	COG3272	Protein of unknown function (DUF1722)
FORC065_1295	COG5212	phosphodiesterase
FORC065_1296	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC065_1298	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC065_1299	COG1984	allophanate hydrolase subunit 2
FORC065_1300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC065_1303	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC065_1305	COG2009	succinate dehydrogenase
FORC065_1306	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC065_1309	COG0567	Dehydrogenase, E1 component
FORC065_1310	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC065_1311	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC065_1312	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FORC065_1313	COG0737	Belongs to the 5'-nucleotidase family
FORC065_1314	COG1271	oxidase subunit
FORC065_1315	COG1294	oxidase, subunit
FORC065_1316	COG4890	Cyd operon protein YbgT
FORC065_1317	COG3790	cyd operon protein YbgE
FORC065_1318	COG0824	Thioesterase
FORC065_1319	COG0811	peptide transport
FORC065_1320	COG0848	biopolymer transport protein
FORC065_1321	COG3064	Membrane
FORC065_1321	COG3064	Membrane
FORC065_1322	COG0823	Involved in the tonB-independent uptake of proteins
FORC065_1323	COG2885	chlorophyll binding
FORC065_1324	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC065_1326	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC065_1329	COG1230	cation diffusion facilitator family transporter
FORC065_1330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC065_1331	COG0588	phosphoglycerate mutase activity
FORC065_1335	COG2017	converts alpha-aldose to the beta-anomer
FORC065_1336	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC065_1337	COG1085	galactose-1-phosphate uridylyltransferase
FORC065_1338	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC065_1340	COG1119	ATPase activity
FORC065_1342	COG2005	Transcriptional regulator
FORC065_1342	COG3585	molybdate ion transport
FORC065_1345	COG4149	molybdate abc transporter
FORC065_1348	COG2706	6-phosphogluconolactonase activity
FORC065_1350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC065_1351	COG0156	8-amino-7-oxononanoate synthase activity
FORC065_1353	COG2226	methyltransferase
FORC065_1357	COG0556	nucleotide-excision repair
FORC065_1358	COG4628	conserved protein (DUF2132)
FORC065_1363	COG1120	ATPase activity
FORC065_1364	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC065_1365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC065_1366	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC065_1367	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC065_1368	COG0314	molybdopterin synthase activity
FORC065_1369	COG0670	Belongs to the BI1 family
FORC065_1370	COG0842	Transport permease protein
FORC065_1371	COG0842	Transport permease protein
FORC065_1372	COG1131	(ABC) transporter
FORC065_1373	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_1374	COG1309	transcriptional regulator
FORC065_1375	COG0513	Belongs to the DEAD box helicase family
FORC065_1376	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC065_1379	COG1686	Belongs to the peptidase S11 family
FORC065_1380	COG0277	FAD linked oxidase domain protein
FORC065_1384	COG2261	transglycosylase associated protein
FORC065_1386	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FORC065_1389	COG4807	Protein conserved in bacteria
FORC065_1395	COG2897	thiosulfate sulfurtransferase activity
FORC065_1400	COG1732	Glycine betaine
FORC065_1402	COG1174	glycine betaine transport
FORC065_1403	COG1125	glycine betaine transport
FORC065_1407	COG0583	DNA-binding transcription factor activity
FORC065_1409	COG0697	spore germination
FORC065_1413	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC065_1420	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC065_1422	COG1126	abc transporter atp-binding protein
FORC065_1423	COG0765	amino acid transport
FORC065_1424	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_1426	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC065_1427	COG0783	Belongs to the Dps family
FORC065_1428	COG4106	trans-aconitate 2-methyltransferase activity
FORC065_1431	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FORC065_1434	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FORC065_1439	COG0488	(ABC) transporter
FORC065_1440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC065_1441	COG0303	'Molybdopterin
FORC065_1444	COG0577	efflux transmembrane transporter activity
FORC065_1444	COG1136	(ABC) transporter
FORC065_1449	COG0583	DNA-binding transcription factor activity
FORC065_1451	COG0477	Major facilitator Superfamily
FORC065_1452	COG0302	gtp cyclohydrolase
FORC065_1453	COG2311	Membrane
FORC065_1459	COG2116	formate transmembrane transporter activity
FORC065_1460	COG2116	formate transmembrane transporter activity
FORC065_1462	COG3383	formate dehydrogenase (NAD+) activity
FORC065_1463	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC065_1465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FORC065_1467	COG3260	NADH ubiquinone oxidoreductase 20
FORC065_1468	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_1470	COG0651	ATP synthesis coupled electron transport
FORC065_1471	COG4237	Hydrogenase 4 membrane
FORC065_1472	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FORC065_1473	COG0650	Formate hydrogenlyase subunit 4
FORC065_1474	COG0651	ATP synthesis coupled electron transport
FORC065_1475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC065_1476	COG0375	protein maturation
FORC065_1477	COG0298	carbon dioxide binding
FORC065_1479	COG2949	membrane
FORC065_1480	COG0281	malic enzyme
FORC065_1483	COG1346	cytolysis
FORC065_1484	COG1380	Effector of murein hydrolase LrgA
FORC065_1485	COG2814	Major facilitator Superfamily
FORC065_1490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC065_1490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC065_1492	COG0489	protein tyrosine kinase activity
FORC065_1493	COG0572	uridine kinase
FORC065_1495	COG2982	Protein involved in outer membrane biogenesis
FORC065_1496	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC065_1497	COG1253	flavin adenine dinucleotide binding
FORC065_1498	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FORC065_1499	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FORC065_1501	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC065_1503	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC065_1503	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC065_1504	COG0107	imidazoleglycerol-phosphate synthase activity
FORC065_1505	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC065_1507	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC065_1507	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC065_1508	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC065_1510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC065_1511	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC065_1512	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_1513	COG1129	ABC transporter
FORC065_1514	COG0371	Dehydrogenase
FORC065_1515	COG0531	amino acid
FORC065_1516	COG2925	Exonuclease
FORC065_1518	COG1289	transmembrane transporter activity
FORC065_1519	COG2926	Belongs to the UPF0265 family
FORC065_1521	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_1522	COG1129	ABC transporter
FORC065_1526	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC065_1527	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC065_1527	COG1648	precorrin-2 dehydrogenase activity
FORC065_1528	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC065_1532	COG4656	Part of a membrane complex involved in electron transport
FORC065_1536	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
FORC065_1552	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FORC065_1554	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FORC065_1567	COG1492	cobalamin metabolic process
FORC065_1571	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC065_1572	COG0583	DNA-binding transcription factor activity
FORC065_1574	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC065_1575	COG2211	Major facilitator Superfamily
FORC065_1588	COG3121	Chaperone
FORC065_1604	COG0137	argininosuccinate synthase activity
FORC065_1605	COG0534	Mate efflux family protein
FORC065_1609	COG0352	thiamine-phosphate diphosphorylase activity
FORC065_1611	COG0561	phosphatase activity
FORC065_1612	COG1349	DNA-binding transcription factor activity
FORC065_1614	COG0784	Response regulator, receiver
FORC065_1614	COG0835	chemotaxis
FORC065_1616	COG4221	oxidoreductase activity
FORC065_1618	COG1063	alcohol dehydrogenase
FORC065_1629	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_1629	COG2205	protein histidine kinase activity
FORC065_1632	COG3842	ATPase activity
FORC065_1634	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC065_1635	COG2271	Major facilitator Superfamily
FORC065_1638	COG4565	transcriptional regulatory protein
FORC065_1639	COG3290	protein histidine kinase activity
FORC065_1640	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FORC065_1641	COG3052	prosthetic group binding
FORC065_1642	COG2301	Belongs to the HpcH HpaI aldolase family
FORC065_1643	COG3051	citrate lyase alpha subunit
FORC065_1646	COG0471	metal ion transport
FORC065_1649	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC065_1652	COG2814	Major facilitator Superfamily
FORC065_1653	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_1653	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_1659	COG1136	(ABC) transporter
FORC065_1659	COG0577	efflux transmembrane transporter activity
FORC065_1660	COG1136	(ABC) transporter
FORC065_1660	COG0577	efflux transmembrane transporter activity
FORC065_1664	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC065_1665	COG1120	ATPase activity
FORC065_1667	COG3228	Belongs to the MtfA family
FORC065_1669	COG1129	ABC transporter
FORC065_1670	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_1673	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC065_1674	COG1070	Carbohydrate kinase
FORC065_1679	COG3121	Chaperone
FORC065_1681	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC065_1687	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_1687	COG0604	alcohol dehydrogenase
FORC065_1687	COG3321	synthase
FORC065_1689	COG1609	Transcriptional regulator
FORC065_1693	COG0840	transmembrane signaling receptor activity
FORC065_1694	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FORC065_1695	COG1285	pathogenesis
FORC065_1697	COG2130	NADP-dependent
FORC065_1698	COG0589	response to stress
FORC065_1703	COG1360	Flagellar Motor Protein
FORC065_1705	COG0835	chemotaxis
FORC065_1706	COG0840	transmembrane signaling receptor activity
FORC065_1707	COG0840	transmembrane signaling receptor activity
FORC065_1708	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC065_1710	COG0745	RESPONSE REGULATOR receiver
FORC065_1711	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC065_1712	COG4935	Belongs to the peptidase S8 family
FORC065_1712	COG1404	Belongs to the peptidase S8 family
FORC065_1713	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC065_1714	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC065_1717	COG3418	PFAM FlgN family protein
FORC065_1718	COG2747	anti-sigma28 factor FlgM
FORC065_1720	COG1815	bacterial-type flagellum-dependent cell motility
FORC065_1721	COG1558	bacterial-type flagellum-dependent cell motility
FORC065_1722	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC065_1729	COG1256	bacterial-type flagellum assembly
FORC065_1734	COG1338	Plays a role in the flagellum-specific transport system
FORC065_1738	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC065_1742	COG1317	bacterial-type flagellum organization
FORC065_1746	COG1677	Flagellar hook-basal body complex protein FliE
FORC065_1753	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC065_1754	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC065_1764	COG1191	sigma factor activity
FORC065_1766	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FORC065_1767	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_1768	COG0765	amino acid transport
FORC065_1769	COG1126	abc transporter atp-binding protein
FORC065_1772	COG0506	proline dehydrogenase activity
FORC065_1772	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FORC065_1772	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FORC065_1776	COG0672	)-iron permease
FORC065_1777	COG2822	iron ion transport
FORC065_1779	COG0655	NAD(P)H dehydrogenase (quinone) activity
FORC065_1781	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FORC065_1782	COG1881	PFAM PEBP family protein
FORC065_1784	COG2233	PERMEase
FORC065_1785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FORC065_1786	COG0778	Nitroreductase
FORC065_1787	COG2267	carboxylic ester hydrolase activity
FORC065_1788	COG0251	oxidation-reduction process
FORC065_1789	COG1335	isochorismatase
FORC065_1790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC065_1791	COG1309	transcriptional regulator
FORC065_1792	COG1113	amino acid transport
FORC065_1797	COG2226	methyltransferase
FORC065_1800	COG0366	Alpha amylase catalytic
FORC065_1802	COG3136	membrane protein required for alginate biosynthesis
FORC065_1804	COG2197	response regulator
FORC065_1805	COG0322	excinuclease ABC activity
FORC065_1806	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC065_1843	COG4695	Portal protein
FORC065_1857	COG4974	Belongs to the 'phage' integrase family
FORC065_1858	COG2801	Transposase and inactivated derivatives
FORC065_1859	COG2963	transposase activity
FORC065_1867	COG0561	phosphatase activity
FORC065_1868	COG2223	nitrite transmembrane transporter activity
FORC065_1870	COG0346	lactoylglutathione lyase activity
FORC065_1874	COG3493	citrate carrier protein
FORC065_1875	COG4565	transcriptional regulatory protein
FORC065_1876	COG3290	protein histidine kinase activity
FORC065_1877	COG1349	DNA-binding transcription factor activity
FORC065_1878	COG3395	kinase activity
FORC065_1879	COG0235	Class ii aldolase
FORC065_1880	COG3622	Belongs to the hyi family
FORC065_1881	COG2066	Belongs to the glutaminase family
FORC065_1884	COG0672	)-iron permease
FORC065_1887	COG0577	efflux transmembrane transporter activity
FORC065_1887	COG1136	(ABC) transporter
FORC065_1889	COG1136	(ABC) transporter
FORC065_1889	COG0577	efflux transmembrane transporter activity
FORC065_1894	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC065_1895	COG4114	ferric iron reductase
FORC065_1897	COG0457	Tetratricopeptide repeat
FORC065_1898	COG0726	polysaccharide deacetylase
FORC065_1898	COG1649	PFAM Uncharacterised BCR, COG1649
FORC065_1899	COG1215	transferase activity, transferring glycosyl groups
FORC065_1900	COG3658	cytochrome
FORC065_1904	COG1702	phosphate starvation-inducible protein PhoH
FORC065_1905	COG0387	Pfam Sodium calcium exchanger
FORC065_1907	COG2814	Major facilitator Superfamily
FORC065_1908	COG0583	DNA-binding transcription factor activity
FORC065_1909	COG3850	Histidine kinase
FORC065_1912	COG1294	oxidase, subunit
FORC065_1913	COG1271	oxidase subunit
FORC065_1914	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC065_1915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC065_1916	COG3138	arginine N-succinyltransferase
FORC065_1918	COG3724	N-succinylarginine dihydrolase activity
FORC065_1919	COG2988	succinylglutamate desuccinylase activity
FORC065_1922	COG1228	amidohydrolase
FORC065_1927	COG3443	Belongs to the bacterial solute-binding protein 9 family
FORC065_1930	COG4942	peptidase
FORC065_1932	COG2222	sugar isomerase
FORC065_1933	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_1934	COG3716	PTS system mannose fructose sorbose family IID component
FORC065_1936	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_1938	COG1349	DNA-binding transcription factor activity
FORC065_1941	COG1187	pseudouridine synthase activity
FORC065_1942	COG0786	glutamate:sodium symporter activity
FORC065_1946	COG0668	transmembrane transport
FORC065_1947	COG0625	glutathione transferase activity
FORC065_1955	COG2203	Gaf domain
FORC065_1955	COG3706	GGDEF domain
FORC065_1955	COG4251	negative regulation of phosphorylation
FORC065_1955	COG5001	Diguanylate cyclase
FORC065_1963	COG2814	Major facilitator Superfamily
FORC065_1965	COG3008	intermembrane lipid transfer
FORC065_1966	COG2995	paraquat-inducible protein a
FORC065_1967	COG1956	GAF domain-containing protein
FORC065_1970	COG0501	Belongs to the peptidase M48B family
FORC065_1976	COG2814	Major facilitator Superfamily
FORC065_1977	COG0823	Involved in the tonB-independent uptake of proteins
FORC065_1979	COG3023	N-Acetylmuramoyl-L-alanine amidase
FORC065_1980	COG1823	symporter activity
FORC065_1981	COG1988	membrane-bound metal-dependent
FORC065_1983	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC065_1984	COG1653	transport
FORC065_1985	COG3842	ATPase activity
FORC065_1986	COG0395	ABC-type sugar transport system, permease component
FORC065_1987	COG1175	transmembrane transport
FORC065_1990	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_1991	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FORC065_1992	COG1917	Cupin 2, conserved barrel domain protein
FORC065_1993	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC065_1995	COG0583	DNA-binding transcription factor activity
FORC065_1997	COG1024	Enoyl-CoA hydratase
FORC065_1999	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC065_1999	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC065_2000	COG3001	Fructosamine kinase
FORC065_2001	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC065_2002	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC065_2003	COG1121	(ABC) transporter
FORC065_2004	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC065_2011	COG1811	Na channel or pump
FORC065_2014	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC065_2015	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FORC065_2016	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC065_2017	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FORC065_2018	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC065_2020	COG0776	regulation of translation
FORC065_2024	COG4139	cobalamin transport
FORC065_2025	COG0386	Belongs to the glutathione peroxidase family
FORC065_2026	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC065_2027	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC065_2028	COG0463	Glycosyl transferase, family 2
FORC065_2029	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC065_2029	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC065_2030	COG0726	polysaccharide deacetylase
FORC065_2031	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC065_2032	COG2076	Multidrug Resistance protein
FORC065_2033	COG2076	Multidrug Resistance protein
FORC065_2034	COG0791	NLP P60 protein
FORC065_2035	COG0095	Lipoate-protein ligase
FORC065_2038	COG3720	iron ion transport
FORC065_2043	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC065_2044	COG0574	Belongs to the PEP-utilizing enzyme family
FORC065_2044	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC065_2045	COG0628	permease
FORC065_2047	COG0247	lactate metabolic process
FORC065_2047	COG0277	FAD linked oxidase domain protein
FORC065_2048	COG2050	protein possibly involved in aromatic compounds catabolism
FORC065_2049	COG0316	Belongs to the HesB IscA family
FORC065_2050	COG0719	Fe-S assembly protein
FORC065_2051	COG0396	ATPase activity
FORC065_2052	COG0719	Fe-S assembly protein
FORC065_2054	COG2166	iron-sulfur cluster assembly
FORC065_2055	COG1376	ErfK ybiS ycfS ynhG family protein
FORC065_2055	COG1388	LysM domain
FORC065_2059	COG0534	Mate efflux family protein
FORC065_2060	COG0307	riboflavin synthase, alpha
FORC065_2061	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC065_2063	COG0583	DNA-binding transcription factor activity
FORC065_2064	COG1609	Transcriptional regulator
FORC065_2068	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC065_2069	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC065_2070	COG0346	lactoylglutathione lyase activity
FORC065_2071	COG1902	pentaerythritol trinitrate reductase activity
FORC065_2072	COG1309	transcriptional regulator
FORC065_2073	COG2194	sulfuric ester hydrolase activity
FORC065_2075	COG3313	Fe-S protein
FORC065_2076	COG4989	oxidoreductase activity
FORC065_2077	COG1289	transmembrane transporter activity
FORC065_2078	COG1566	PFAM secretion protein HlyD family protein
FORC065_2080	COG1846	Transcriptional regulator
FORC065_2081	COG3133	Outer membrane lipoprotein
FORC065_2083	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC065_2085	COG0259	pyridoxamine-phosphate oxidase activity
FORC065_2086	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC065_2088	COG0625	glutathione transferase activity
FORC065_2093	COG3104	oligopeptide transport
FORC065_2095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC065_2095	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC065_2097	COG4172	Belongs to the ABC transporter superfamily
FORC065_2099	COG4171	peptide transport system, permease
FORC065_2101	COG4166	transmembrane transport
FORC065_2104	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC065_2105	COG1842	Phage shock protein A
FORC065_2107	COG1983	PspC domain protein
FORC065_2109	COG3106	COG3106 Predicted ATPase
FORC065_2111	COG5642	Protein of unknown function (DUF2384)
FORC065_2113	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FORC065_2114	COG4948	Mandelate Racemase Muconate Lactonizing
FORC065_2115	COG2866	Carboxypeptidase
FORC065_2116	COG4166	transmembrane transport
FORC065_2119	COG0598	Magnesium transport protein CorA
FORC065_2120	COG0037	tRNA processing
FORC065_2121	COG3711	transcriptional antiterminator
FORC065_2122	COG2190	(PTS) system
FORC065_2122	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_2122	COG1263	PTS System
FORC065_2124	COG0674	pyruvate-flavodoxin oxidoreductase activity
FORC065_2124	COG1013	pyruvate-flavodoxin oxidoreductase activity
FORC065_2124	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FORC065_2124	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_2127	COG1285	pathogenesis
FORC065_2128	COG3042	response to heat
FORC065_2129	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC065_2132	COG3784	Protein of unknown function (DUF1318)
FORC065_2134	COG1070	Carbohydrate kinase
FORC065_2135	COG0246	Mannitol dehydrogenase
FORC065_2137	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC065_2138	COG1643	Atp-dependent helicase
FORC065_2141	COG3591	Belongs to the peptidase S1B family
FORC065_2144	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC065_2145	COG2205	protein histidine kinase activity
FORC065_2146	COG0745	RESPONSE REGULATOR receiver
FORC065_2150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC065_2151	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC065_2152	COG0589	response to stress
FORC065_2154	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC065_2157	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FORC065_2159	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_2161	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC065_2162	COG0738	Major facilitator superfamily
FORC065_2166	COG1011	Hydrolase
FORC065_2167	COG0440	acetolactate synthase activity
FORC065_2168	COG0028	Belongs to the TPP enzyme family
FORC065_2172	COG2271	Major facilitator Superfamily
FORC065_2176	COG0583	DNA-binding transcription factor activity
FORC065_2178	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC065_2184	COG1522	sequence-specific DNA binding
FORC065_2187	COG0426	domain, Protein
FORC065_2187	COG1773	rubredoxin
FORC065_2188	COG3604	Transcriptional regulator
FORC065_2192	COG0625	glutathione transferase activity
FORC065_2200	COG0477	Major facilitator Superfamily
FORC065_2201	COG4221	oxidoreductase activity
FORC065_2202	COG1742	UPF0060 membrane protein
FORC065_2209	COG1940	carbohydrate kinase activity
FORC065_2210	COG0583	DNA-binding transcription factor activity
FORC065_2211	COG2814	Major facilitator Superfamily
FORC065_2217	COG0114	fumarate hydratase activity
FORC065_2219	COG5339	Protein conserved in bacteria
FORC065_2221	COG1609	Transcriptional regulator
FORC065_2222	COG1263	PTS System
FORC065_2222	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_2223	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FORC065_2224	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC065_2225	COG0385	Bile acid
FORC065_2226	COG0673	inositol 2-dehydrogenase activity
FORC065_2228	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_2229	COG1129	ABC transporter
FORC065_2230	COG1879	ABC-type sugar transport system periplasmic component
FORC065_2232	COG2160	L-arabinose isomerase activity
FORC065_2239	COG4657	Part of a membrane complex involved in electron transport
FORC065_2241	COG4656	Part of a membrane complex involved in electron transport
FORC065_2243	COG2207	Transcriptional regulator
FORC065_2243	COG3708	Transcriptional regulator
FORC065_2246	COG4659	FMN binding
FORC065_2248	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC065_2251	COG0243	molybdopterin cofactor binding
FORC065_2252	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC065_2253	COG1966	Carbon starvation protein
FORC065_2254	COG2879	small protein
FORC065_2255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC065_2256	COG1349	DNA-binding transcription factor activity
FORC065_2258	COG0235	Class ii aldolase
FORC065_2260	COG0023	Translation Initiation Factor
FORC065_2261	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC065_2263	COG3135	benzoate transporter
FORC065_2264	COG1396	sequence-specific DNA binding
FORC065_2266	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC065_2267	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC065_2274	COG0583	DNA-binding transcription factor activity
FORC065_2277	COG0616	signal peptide processing
FORC065_2278	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_2279	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC065_2280	COG1187	pseudouridine synthase activity
FORC065_2281	COG0009	L-threonylcarbamoyladenylate synthase
FORC065_2282	COG0613	PHP domain protein
FORC065_2285	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC065_2287	COG0134	indole-3-glycerol-phosphate synthase activity
FORC065_2287	COG0135	phosphoribosylanthranilate isomerase activity
FORC065_2288	COG0133	tryptophan synthase activity
FORC065_2289	COG0159	tryptophan synthase activity
FORC065_2291	COG3047	cAMP biosynthetic process
FORC065_2292	COG0727	PFAM Uncharacterised protein family (UPF0153)
FORC065_2295	COG2917	probably involved in intracellular septation
FORC065_2297	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC065_2298	COG2350	Protein conserved in bacteria
FORC065_2303	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC065_2304	COG3099	Belongs to the UPF0263 family
FORC065_2307	COG0444	Belongs to the ABC transporter superfamily
FORC065_2308	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC065_2314	COG2095	MarC family integral membrane protein
FORC065_2315	COG1454	alcohol dehydrogenase
FORC065_2315	COG1012	belongs to the aldehyde dehydrogenase family
FORC065_2317	COG2916	Histone family protein nucleoid-structuring protein H-NS
FORC065_2319	COG0745	RESPONSE REGULATOR receiver
FORC065_2320	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC065_2322	COG3012	SEC-C Motif Domain Protein
FORC065_2323	COG0788	formyltetrahydrofolate deformylase activity
FORC065_2325	COG0583	DNA-binding transcription factor activity
FORC065_2327	COG0708	Exodeoxyribonuclease III
FORC065_2328	COG0494	nUDIX hydrolase
FORC065_2330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC065_2333	COG0778	Nitroreductase
FORC065_2334	COG0616	signal peptide processing
FORC065_2335	COG0252	asparaginase activity
FORC065_2336	COG1335	isochorismatase
FORC065_2337	COG3139	Protein of unknown function (DUF1315)
FORC065_2338	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC065_2341	COG3713	MltA-interacting MipA family protein
FORC065_2343	COG2766	serine protein kinase
FORC065_2344	COG2718	Belongs to the UPF0229 family
FORC065_2347	COG0583	DNA-binding transcription factor activity
FORC065_2350	COG2814	Major facilitator Superfamily
FORC065_2351	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC065_2352	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC065_2355	COG2719	SpoVR family
FORC065_2356	COG2186	Transcriptional regulator
FORC065_2357	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC065_2358	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC065_2363	COG2983	Belongs to the UPF0260 family
FORC065_2364	COG0179	Fumarylacetoacetate (FAA) hydrolase
FORC065_2366	COG3100	YcgL domain-containing protein
FORC065_2368	COG0850	regulation of cytokinetic process
FORC065_2369	COG2894	cell division
FORC065_2370	COG2894	cell division
FORC065_2371	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC065_2372	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC065_2373	COG0318	PFAM AMP-dependent synthetase and ligase
FORC065_2374	COG3065	identical protein binding
FORC065_2378	COG0251	oxidation-reduction process
FORC065_2379	COG2076	Multidrug Resistance protein
FORC065_2380	COG2076	Multidrug Resistance protein
FORC065_2382	COG0800	Aldolase
FORC065_2383	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC065_2384	COG1737	Transcriptional regulator
FORC065_2385	COG0469	pyruvate kinase activity
FORC065_2387	COG0739	heme binding
FORC065_2388	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC065_2389	COG1121	(ABC) transporter
FORC065_2390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC065_2392	COG2255	four-way junction helicase activity
FORC065_2393	COG0632	four-way junction helicase activity
FORC065_2394	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC065_2395	COG0217	transcriptional regulatory protein
FORC065_2396	COG0494	nUDIX hydrolase
FORC065_2397	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC065_2399	COG1335	isochorismatase
FORC065_2400	COG1801	Protein of unknown function DUF72
FORC065_2401	COG3788	relative of glutathione S-transferase, MAPEG superfamily
FORC065_2402	COG2226	methyltransferase
FORC065_2403	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC065_2404	COG3142	Participates in the control of copper homeostasis
FORC065_2405	COG3102	Protein conserved in bacteria
FORC065_2406	COG0018	arginyl-trna synthetase
FORC065_2407	COG0728	peptidoglycan biosynthetic process
FORC065_2409	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC065_2414	COG0477	Major facilitator Superfamily
FORC065_2417	COG3381	protein complex oligomerization
FORC065_2418	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC065_2419	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC065_2421	COG3706	GGDEF domain
FORC065_2422	COG0659	secondary active sulfate transmembrane transporter activity
FORC065_2423	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC065_2426	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC065_2427	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC065_2428	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC065_2429	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC065_2431	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC065_2436	COG0193	aminoacyl-tRNA hydrolase activity
FORC065_2438	COG0012	GTP binding
FORC065_2439	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC065_2441	COG4948	Mandelate Racemase Muconate Lactonizing
FORC065_2442	COG0800	Aldolase
FORC065_2443	COG3734	2-keto-3-deoxy-galactonokinase
FORC065_2444	COG2186	Transcriptional regulator
FORC065_2447	COG2979	Protein of unknown function (DUF533)
FORC065_2449	COG3772	lysozyme
FORC065_2457	COG0488	(ABC) transporter
FORC065_2473	COG0582	viral genome integration into host DNA
FORC065_2476	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC065_2477	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC065_2481	COG3077	Addiction module antitoxin, RelB DinJ family
FORC065_2492	COG0477	Major facilitator Superfamily
FORC065_2494	COG3423	Transcriptional regulator
FORC065_2516	COG3772	lysozyme
FORC065_2522	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC065_2548	COG1276	copper resistance
FORC065_2549	COG2372	response to copper ion
FORC065_2551	COG1528	Iron-storage protein
FORC065_2555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC065_2556	COG1770	oligopeptidase
FORC065_2558	COG3097	Belongs to the UPF0267 family
FORC065_2559	COG3141	response to X-ray
FORC065_2560	COG0513	Belongs to the DEAD box helicase family
FORC065_2562	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC065_2563	COG3140	Belongs to the UPF0181 family
FORC065_2565	COG0494	nUDIX hydrolase
FORC065_2567	COG1760	l-serine dehydratase
FORC065_2571	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_2571	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_2572	COG3715	PTS system
FORC065_2573	COG3716	PTS system mannose fructose sorbose family IID component
FORC065_2574	COG4811	Protein of unknown function (DUF986)
FORC065_2575	COG1971	Probably functions as a manganese efflux pump
FORC065_2578	COG5001	Diguanylate cyclase
FORC065_2578	COG5002	protein histidine kinase activity
FORC065_2578	COG3447	MASE1 domain protein
FORC065_2580	COG2226	methyltransferase
FORC065_2581	COG0768	penicillin binding
FORC065_2582	COG1496	oxidoreductase activity
FORC065_2587	COG1113	amino acid transport
FORC065_2595	COG2207	Transcriptional regulator
FORC065_2600	COG1132	(ABC) transporter
FORC065_2607	COG3755	Protein conserved in bacteria
FORC065_2611	COG2271	Major facilitator Superfamily
FORC065_2613	COG4948	Mandelate Racemase Muconate Lactonizing
FORC065_2614	COG1802	Transcriptional regulator
FORC065_2615	COG1063	alcohol dehydrogenase
FORC065_2616	COG0246	Mannitol dehydrogenase
FORC065_2617	COG2721	sulfolactate sulfo-lyase activity
FORC065_2618	COG1126	abc transporter atp-binding protein
FORC065_2619	COG0765	amino acid transport
FORC065_2620	COG0765	amino acid transport
FORC065_2625	COG1733	regulation of RNA biosynthetic process
FORC065_2626	COG0702	epimerase
FORC065_2639	COG0840	transmembrane signaling receptor activity
FORC065_2649	COG5444	nuclease activity
FORC065_2651	COG0538	isocitrate dehydrogenase activity
FORC065_2652	COG1187	pseudouridine synthase activity
FORC065_2654	COG0482	sulfurtransferase activity
FORC065_2655	COG2915	High frequency lysogenization protein hflD homolog
FORC065_2656	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC065_2658	COG0745	RESPONSE REGULATOR receiver
FORC065_2660	COG2850	peptidyl-arginine hydroxylation
FORC065_2663	COG1940	carbohydrate kinase activity
FORC065_2664	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC065_2666	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC065_2667	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC065_2668	COG3134	Outer membrane lipoprotein
FORC065_2670	COG1252	NADH dehydrogenase
FORC065_2671	COG3150	esterase
FORC065_2672	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC065_2674	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
FORC065_2675	COG5633	Lipoprotein
FORC065_2676	COG0537	adenosine 5'-monophosphoramidase activity
FORC065_2679	COG1263	PTS System
FORC065_2679	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_2680	COG0084	hydrolase, TatD family'
FORC065_2681	COG0470	DNA polymerase III
FORC065_2683	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC065_2684	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC065_2685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC065_2687	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_2688	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORC065_2689	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC065_2690	COG0416	fatty acid biosynthetic process
FORC065_2691	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FORC065_2692	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC065_2693	COG0424	maF-like protein
FORC065_2694	COG0564	pseudouridine synthase activity
FORC065_2695	COG1530	ribonuclease E activity
FORC065_2696	COG1530	ribonuclease E activity
FORC065_2696	COG1530	ribonuclease E activity
FORC065_2697	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC065_2698	COG0418	dihydroorotase activity
FORC065_2704	COG0628	permease
FORC065_2705	COG1054	Belongs to the UPF0176 family
FORC065_2713	COG2259	Doxx family
FORC065_2715	COG2814	Major facilitator Superfamily
FORC065_2718	COG5645	(Lipo)protein
FORC065_2720	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FORC065_2723	COG3263	regulation of cellular component size
FORC065_2725	COG3916	Acyl-homoserine-lactone synthase
FORC065_2726	COG2771	luxR family
FORC065_2727	COG4235	cytochrome complex assembly
FORC065_2728	COG3088	subunit of a heme lyase
FORC065_2730	COG1138	Cytochrome C-type biogenesis protein
FORC065_2731	COG3301	Polysulphide reductase, NrfD
FORC065_2732	COG0437	4 iron, 4 sulfur cluster binding
FORC065_2733	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC065_2735	COG1309	transcriptional regulator
FORC065_2736	COG3250	beta-galactosidase activity
FORC065_2739	COG2920	part of a sulfur-relay system
FORC065_2740	COG1254	Belongs to the acylphosphatase family
FORC065_2743	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC065_2744	COG3785	DNA binding
FORC065_2745	COG1832	CoA-binding protein
FORC065_2747	COG1803	Methylglyoxal synthase
FORC065_2748	COG0210	DNA helicase
FORC065_2749	COG3304	Inner membrane component domain
FORC065_2750	COG1289	transmembrane transporter activity
FORC065_2751	COG3070	regulator of competence-specific genes
FORC065_2752	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
FORC065_2754	COG3120	sequence-specific DNA binding
FORC065_2755	COG1067	ATP-dependent peptidase activity
FORC065_2756	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC065_2758	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC065_2759	COG3009	Protein conserved in bacteria
FORC065_2760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC065_2760	COG3008	intermembrane lipid transfer
FORC065_2761	COG2995	paraquat-inducible protein a
FORC065_2762	COG0488	(ABC) transporter
FORC065_2763	COG0116	Belongs to the methyltransferase superfamily
FORC065_2763	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC065_2764	COG0633	Ferredoxin
FORC065_2764	COG3217	Mosc domain protein beta barrel domain protein
FORC065_2767	COG0167	dihydroorotate dehydrogenase activity
FORC065_2768	COG0308	aminopeptidase N
FORC065_2770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC065_2771	COG0017	Asparaginyl-tRNA synthetase
FORC065_2773	COG1448	Aminotransferase
FORC065_2774	COG2200	EAL domain
FORC065_2775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC065_2776	COG3108	Peptidase M15
FORC065_2777	COG2989	Protein conserved in bacteria
FORC065_2778	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC065_2780	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC065_2781	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC065_2783	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC065_2784	COG3173	Aminoglycoside phosphotransferase
FORC065_2785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC065_2786	COG2835	tetraacyldisaccharide 4'-kinase activity
FORC065_2788	COG1278	Cold shock
FORC065_2791	COG5383	Protein conserved in bacteria
FORC065_2792	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC065_2795	COG0776	regulation of translation
FORC065_2796	COG0539	negative regulation of cytoplasmic translation
FORC065_2797	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC065_2798	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC065_2799	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC065_2800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC065_2801	COG2323	membrane
FORC065_2802	COG0252	asparaginase activity
FORC065_2803	COG1944	ATP diphosphatase activity
FORC065_2805	COG2116	formate transmembrane transporter activity
FORC065_2806	COG1882	Formate acetyltransferase
FORC065_2807	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC065_2808	COG2814	Major facilitator Superfamily
FORC065_2809	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC065_2810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC065_2811	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC065_2812	COG1674	ftsk spoiiie
FORC065_2812	COG3107	peptidoglycan biosynthetic process
FORC065_2813	COG1522	sequence-specific DNA binding
FORC065_2814	COG0492	ferredoxin-NADP+ reductase activity
FORC065_2816	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC065_2818	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC065_2819	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC065_2820	COG0542	response to heat
FORC065_2821	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC065_2822	COG1278	Cold shock
FORC065_2824	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_2825	COG2990	Protein conserved in bacteria
FORC065_2827	COG2431	L-lysine efflux transmembrane transporter activity
FORC065_2828	COG1151	hydroxylamine reductase activity
FORC065_2829	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC065_2830	COG0028	Belongs to the TPP enzyme family
FORC065_2832	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC065_2834	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC065_2836	COG1126	abc transporter atp-binding protein
FORC065_2837	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_2838	COG4215	(ABC) transporter
FORC065_2839	COG4160	amino acid transport
FORC065_2843	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_2844	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC065_2847	COG1177	transmembrane transport
FORC065_2848	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC065_2849	COG3842	ATPase activity
FORC065_2851	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC065_2856	COG0569	domain protein
FORC065_2856	COG2985	domain, Protein
FORC065_2858	COG0671	phosphoesterase, PA-phosphatase related
FORC065_2859	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC065_2860	COG1349	DNA-binding transcription factor activity
FORC065_2862	COG0814	amino acid
FORC065_2863	COG1760	l-serine dehydratase
FORC065_2864	COG1686	Belongs to the peptidase S11 family
FORC065_2866	COG0626	cystathionine gamma-synthase activity
FORC065_2867	COG2011	ABC-type metal ion transport system permease component
FORC065_2873	COG0625	glutathione transferase activity
FORC065_2874	COG4771	TonB-dependent receptor
FORC065_2877	COG0833	amino acid
FORC065_2878	COG0583	DNA-binding transcription factor activity
FORC065_2880	COG2855	membrane
FORC065_2881	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC065_2886	COG3710	Transcriptional regulator
FORC065_2887	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC065_2887	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC065_2887	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC065_2888	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC065_2891	COG3005	denitrification pathway
FORC065_2892	COG0243	molybdopterin cofactor binding
FORC065_2896	COG1312	Catalyzes the dehydration of D-mannonate
FORC065_2898	COG0246	Mannitol dehydrogenase
FORC065_2900	COG2186	Transcriptional regulator
FORC065_2901	COG0523	cobalamin synthesis protein
FORC065_2902	COG0671	phosphoesterase, PA-phosphatase related
FORC065_2903	COG0791	NLP P60 protein
FORC065_2904	COG2200	EAL domain
FORC065_2905	COG4166	transmembrane transport
FORC065_2906	COG4174	ABC transporter (Permease)
FORC065_2907	COG4239	(ABC) transporter, permease
FORC065_2908	COG4172	Belongs to the ABC transporter superfamily
FORC065_2911	COG2814	Major facilitator Superfamily
FORC065_2912	COG1187	pseudouridine synthase activity
FORC065_2913	COG1061	Type III restriction enzyme res subunit
FORC065_2915	COG3081	Nucleoid-associated protein
FORC065_2916	COG3082	Protein of unknown function (DUF1414)
FORC065_2920	COG2723	6-phospho-beta-galactosidase activity
FORC065_2921	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_2921	COG1263	PTS System
FORC065_2921	COG2190	(PTS) system
FORC065_2922	COG1737	Transcriptional regulator
FORC065_2926	COG3299	homolog of phage Mu protein gp47
FORC065_2934	COG4386	tail sheath protein
FORC065_2950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FORC065_2952	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC065_2954	COG1132	(ABC) transporter
FORC065_2958	COG2198	Histidine kinase
FORC065_2958	COG0642	Histidine kinase
FORC065_2962	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC065_2963	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC065_2965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC065_2967	COG4574	serine-type endopeptidase inhibitor activity
FORC065_2969	COG0814	amino acid
FORC065_2974	COG1441	menaquinone biosynthetic process
FORC065_2975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC065_2976	COG0596	Alpha beta hydrolase
FORC065_2977	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC065_2979	COG1169	isochorismate synthase
FORC065_2983	COG4575	ribosome binding
FORC065_2987	COG0129	dihydroxy-acid dehydratase activity
FORC065_2988	COG4702	Belongs to the UPF0303 family
FORC065_2990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC065_2991	COG1609	Transcriptional regulator
FORC065_2992	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_2999	COG1007	ATP synthesis coupled electron transport
FORC065_3000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_3002	COG0713	ATP synthesis coupled electron transport
FORC065_3003	COG0839	Belongs to the complex I subunit 6 family
FORC065_3004	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_3005	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FORC065_3006	COG1034	ATP synthesis coupled electron transport
FORC065_3009	COG0649	NAD binding
FORC065_3009	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_3010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_3011	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC065_3012	COG0583	DNA-binding transcription factor activity
FORC065_3014	COG0436	Aminotransferase
FORC065_3016	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC065_3017	COG0471	metal ion transport
FORC065_3017	COG0490	domain, Protein
FORC065_3019	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC065_3020	COG3013	Belongs to the UPF0304 family
FORC065_3022	COG3092	negative regulation of chromosome organization
FORC065_3025	COG0280	phosphate acetyltransferase
FORC065_3025	COG0857	belongs to the CobB CobQ family
FORC065_3026	COG1609	Transcriptional regulator
FORC065_3027	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_3029	COG3037	sugar-specific permease SgaT UlaA
FORC065_3030	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FORC065_3031	COG0622	Phosphoesterase
FORC065_3033	COG1090	epimerase
FORC065_3034	COG4598	ABC transporter
FORC065_3035	COG4160	amino acid transport
FORC065_3036	COG4215	(ABC) transporter
FORC065_3037	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_3039	COG0163	prenyltransferase activity
FORC065_3041	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC065_3042	COG1286	toxin biosynthetic process
FORC065_3043	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC065_3044	COG0285	dihydrofolate synthase activity
FORC065_3046	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC065_3047	COG0586	Pfam SNARE associated Golgi protein
FORC065_3049	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC065_3050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC065_3052	COG0697	spore germination
FORC065_3053	COG0697	spore germination
FORC065_3055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC065_3061	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FORC065_3063	COG1609	Transcriptional regulator
FORC065_3065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC065_3066	COG2723	6-phospho-beta-galactosidase activity
FORC065_3067	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC065_3069	COG1794	racemase activity, acting on amino acids and derivatives
FORC065_3071	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC065_3072	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC065_3072	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC065_3074	COG3101	peptidyl-lysine hydroxylation
FORC065_3075	COG0730	response to heat
FORC065_3076	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FORC065_3077	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC065_3078	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC065_3080	COG2840	Smr protein MutS2
FORC065_3081	COG2062	phosphohistidine phosphatase, SixA
FORC065_3083	COG0183	Belongs to the thiolase family
FORC065_3084	COG3691	Protein conserved in bacteria
FORC065_3089	COG3088	subunit of a heme lyase
FORC065_3089	COG4235	cytochrome complex assembly
FORC065_3091	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC065_3092	COG1138	Cytochrome C-type biogenesis protein
FORC065_3093	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC065_3094	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC065_3095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC065_3097	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC065_3099	COG2116	formate transmembrane transporter activity
FORC065_3107	COG4977	sequence-specific DNA binding
FORC065_3113	COG3121	Chaperone
FORC065_3115	COG3121	Chaperone
FORC065_3119	COG3210	domain, Protein
FORC065_3125	COG3210	domain, Protein
FORC065_3129	COG2824	Alkylphosphonate utilization operon protein PhnA
FORC065_3130	COG1695	Transcriptional regulator
FORC065_3132	COG2723	6-phospho-beta-galactosidase activity
FORC065_3133	COG1263	PTS System
FORC065_3133	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_3135	COG2353	YceI-like domain
FORC065_3136	COG3038	cytochrome b561
FORC065_3138	COG0657	acetylesterase activity
FORC065_3138	COG2755	lipolytic protein G-D-S-L family
FORC065_3142	COG1127	ABC transporter
FORC065_3143	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC065_3148	COG0531	amino acid
FORC065_3149	COG2951	lytic endotransglycosylase activity
FORC065_3155	COG2723	6-phospho-beta-galactosidase activity
FORC065_3159	COG1598	PFAM Uncharacterised protein family UPF0150
FORC065_3161	COG3038	cytochrome b561
FORC065_3162	COG0436	Aminotransferase
FORC065_3165	COG3275	phosphorelay sensor kinase activity
FORC065_3166	COG3279	Response regulator of the LytR AlgR family
FORC065_3167	COG2223	nitrite transmembrane transporter activity
FORC065_3168	COG0837	glucose binding
FORC065_3171	COG3961	Belongs to the TPP enzyme family
FORC065_3173	COG0667	Aldo Keto reductase
FORC065_3176	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC065_3177	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC065_3178	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC065_3182	COG3530	Putative quorum-sensing-regulated virulence factor
FORC065_3183	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC065_3187	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_3188	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC065_3190	COG2205	protein histidine kinase activity
FORC065_3191	COG0745	RESPONSE REGULATOR receiver
FORC065_3192	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_3197	COG4208	sulfate ABC transporter
FORC065_3198	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FORC065_3199	COG4150	thiosulfate binding
FORC065_3201	COG1737	Transcriptional regulator
FORC065_3203	COG2731	YhcH YjgK YiaL family protein
FORC065_3206	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC065_3207	COG2837	iron assimilation
FORC065_3210	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC065_3211	COG0456	acetyltransferase
FORC065_3212	COG0408	coproporphyrinogen oxidase activity
FORC065_3213	COG1671	Belongs to the UPF0178 family
FORC065_3215	COG2197	response regulator
FORC065_3218	COG0494	nUDIX hydrolase
FORC065_3221	COG3005	denitrification pathway
FORC065_3222	COG3043	anaerobic respiration
FORC065_3223	COG0243	molybdopterin cofactor binding
FORC065_3224	COG3062	negative regulation of establishment of protein localization
FORC065_3225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC065_3226	COG2197	response regulator
FORC065_3228	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC065_3232	COG1393	Belongs to the ArsC family
FORC065_3233	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC065_3234	COG1876	peptidase activity
FORC065_3236	COG0400	carboxylic ester hydrolase activity
FORC065_3237	COG1444	tRNA N-acetyltransferase activity
FORC065_3238	COG2707	UPF0756 membrane protein
FORC065_3239	COG2321	neutral zinc metallopeptidase
FORC065_3240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC065_3241	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC065_3242	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC065_3243	COG2716	regulation of RNA biosynthetic process
FORC065_3244	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC065_3246	COG0628	permease
FORC065_3247	COG4783	chaperone-mediated protein folding
FORC065_3248	COG1393	Belongs to the ArsC family
FORC065_3249	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC065_3250	COG2233	PERMEase
FORC065_3251	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC065_3252	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC065_3254	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC065_3256	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC065_3260	COG0581	inorganic phosphate transmembrane transporter activity
FORC065_3261	COG0573	inorganic phosphate transmembrane transporter activity
FORC065_3262	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC065_3265	COG2239	Acts as a magnesium transporter
FORC065_3266	COG5002	protein histidine kinase activity
FORC065_3266	COG5001	Diguanylate cyclase
FORC065_3266	COG3447	MASE1 domain protein
FORC065_3267	COG0443	Heat shock 70 kDa protein
FORC065_3269	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_3271	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC065_3273	COG0477	Major facilitator Superfamily
FORC065_3274	COG2205	protein histidine kinase activity
FORC065_3275	COG0745	RESPONSE REGULATOR receiver
FORC065_3276	COG3422	double-strand break repair
FORC065_3282	COG3730	PTS system glucitol sorbitol-specific
FORC065_3285	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_3287	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_3288	COG1349	DNA-binding transcription factor activity
FORC065_3293	COG0351	phosphomethylpyrimidine kinase
FORC065_3300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC065_3300	COG0519	Catalyzes the synthesis of GMP from XMP
FORC065_3301	COG0516	GMP reductase activity
FORC065_3301	COG0517	IMP dehydrogenase activity
FORC065_3303	COG1645	bacterial-type flagellum-dependent swarming motility
FORC065_3305	COG1160	GTP binding
FORC065_3307	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC065_3308	COG2976	Protein conserved in bacteria
FORC065_3309	COG0124	histidyl-tRNA synthetase
FORC065_3310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC065_3311	COG1426	Protein conserved in bacteria
FORC065_3313	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC065_3314	COG0105	UTP biosynthetic process
FORC065_3317	COG4953	penicillin-binding protein 1C
FORC065_3318	COG2373	Large extracellular alpha-helical protein
FORC065_3320	COG3468	outer membrane autotransporter barrel domain protein
FORC065_3323	COG2975	iron-sulfur cluster assembly
FORC065_3324	COG0633	Ferredoxin
FORC065_3325	COG0443	Heat shock 70 kDa protein
FORC065_3326	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC065_3327	COG0316	Belongs to the HesB IscA family
FORC065_3328	COG0822	iron-sulfur transferase activity
FORC065_3330	COG1959	2 iron, 2 sulfur cluster binding
FORC065_3331	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FORC065_3333	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FORC065_3334	COG3683	transport system, periplasmic component
FORC065_3335	COG3711	transcriptional antiterminator
FORC065_3336	COG2814	Major facilitator Superfamily
FORC065_3337	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC065_3339	COG2188	Transcriptional regulator
FORC065_3341	COG3457	Alanine racemase
FORC065_3342	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FORC065_3345	COG0347	Belongs to the P(II) protein family
FORC065_3346	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC065_3346	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC065_3348	COG2204	response regulator
FORC065_3349	COG3170	Tfp pilus assembly protein FimV
FORC065_3355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC065_3358	COG0560	Phosphoserine phosphatase
FORC065_3361	COG1737	Transcriptional regulator
FORC065_3362	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC065_3363	COG2610	gluconate transmembrane transporter activity
FORC065_3365	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC065_3366	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC065_3367	COG1381	Involved in DNA repair and RecF pathway recombination
FORC065_3368	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC065_3369	COG0571	ribonuclease III activity
FORC065_3371	COG0481	GTPase activity
FORC065_3373	COG3086	response to oxidative stress
FORC065_3375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC065_3378	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC065_3379	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC065_3380	COG0513	Belongs to the DEAD box helicase family
FORC065_3384	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC065_3385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC065_3386	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC065_3388	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC065_3389	COG0497	DNA recombination
FORC065_3390	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC065_3392	COG2867	negative regulation of translational initiation
FORC065_3393	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC065_3398	COG3778	Protein conserved in bacteria
FORC065_3399	COG3299	homolog of phage Mu protein gp47
FORC065_3408	COG4386	tail sheath protein
FORC065_3416	COG0740	serine-type endopeptidase activity
FORC065_3418	COG1802	Transcriptional regulator
FORC065_3418	COG4626	Terminase
FORC065_3424	COG3772	lysozyme
FORC065_3431	COG1403	HNH endonuclease
FORC065_3435	COG4725	Belongs to the MT-A70-like family
FORC065_3436	COG1802	Transcriptional regulator
FORC065_3436	COG4626	Terminase
FORC065_3451	COG0582	viral genome integration into host DNA
FORC065_3452	COG0582	viral genome integration into host DNA
FORC065_3468	COG0084	hydrolase, TatD family'
FORC065_3482	COG0577	efflux transmembrane transporter activity
FORC065_3482	COG1136	(ABC) transporter
FORC065_3487	COG3394	polysaccharide catabolic process
FORC065_3488	COG1917	Cupin 2, conserved barrel domain protein
FORC065_3488	COG2169	Transcriptional regulator
FORC065_3489	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC065_3491	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC065_3495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC065_3499	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FORC065_3502	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FORC065_3503	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FORC065_3505	COG0804	urea catabolic process
FORC065_3507	COG0831	urea catabolic process
FORC065_3510	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC065_3511	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC065_3518	COG1278	Cold shock
FORC065_3523	COG2207	Transcriptional regulator
FORC065_3528	COG4575	ribosome binding
FORC065_3530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC065_3532	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC065_3533	COG1780	Probably involved in ribonucleotide reductase function
FORC065_3535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC065_3538	COG4176	ABC-type proline glycine betaine transport system permease component
FORC065_3539	COG2113	Glycine betaine
FORC065_3541	COG0328	RNA-DNA hybrid ribonuclease activity
FORC065_3542	COG2226	methyltransferase
FORC065_3543	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC065_3544	COG1388	LysM domain
FORC065_3544	COG0741	lytic transglycosylase activity
FORC065_3545	COG3021	interspecies interaction between organisms
FORC065_3548	COG0583	DNA-binding transcription factor activity
FORC065_3549	COG0656	L-ascorbic acid biosynthetic process
FORC065_3551	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC065_3553	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_3563	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC065_3566	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC065_3572	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC065_3574	COG2011	ABC-type metal ion transport system permease component
FORC065_3578	COG1720	tRNA m6t6A37 methyltransferase activity
FORC065_3580	COG0442	prolyl-tRNA aminoacylation
FORC065_3583	COG4681	YaeQ
FORC065_3585	COG4568	rho-dependent transcription termination
FORC065_3588	COG0346	lactoylglutathione lyase activity
FORC065_3589	COG1982	Orn Lys Arg decarboxylase major
FORC065_3590	COG0825	malonyl-CoA metabolic process
FORC065_3592	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC065_3594	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC065_3595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC065_3596	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC065_3597	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC065_3599	COG0750	zinc metalloprotease
FORC065_3600	COG0575	Belongs to the CDS family
FORC065_3602	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC065_3603	COG0233	cytoplasmic translational termination
FORC065_3604	COG0528	UMP kinase activity
FORC065_3605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC065_3606	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC065_3609	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC065_3610	COG2171	N-acyltransferase activity
FORC065_3613	COG0564	pseudouridine synthase activity
FORC065_3614	COG3098	single-species biofilm formation
FORC065_3617	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC065_3617	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC065_3618	COG1611	Belongs to the LOG family
FORC065_3619	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC065_3620	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC065_3621	COG2363	Small membrane protein
FORC065_3624	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC065_3625	COG2166	iron-sulfur cluster assembly
FORC065_3626	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC065_3627	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC065_3629	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC065_3630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC065_3630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC065_3631	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC065_3633	COG1025	Belongs to the peptidase M16 family
FORC065_3634	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC065_3638	COG2165	general secretion pathway protein
FORC065_3639	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC065_3640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC065_3642	COG1051	belongs to the nudix hydrolase family
FORC065_3644	COG0861	Integral membrane protein TerC family
FORC065_3645	COG0667	Aldo Keto reductase
FORC065_3646	COG0477	Major facilitator Superfamily
FORC065_3647	COG0204	Acyl-transferase
FORC065_3647	COG0318	PFAM AMP-dependent synthetase and ligase
FORC065_3649	COG1609	Transcriptional regulator
FORC065_3651	COG0583	DNA-binding transcription factor activity
FORC065_3652	COG2814	Major facilitator Superfamily
FORC065_3656	COG0840	transmembrane signaling receptor activity
FORC065_3660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FORC065_3667	COG2165	general secretion pathway protein
FORC065_3669	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC065_3675	COG1733	regulation of RNA biosynthetic process
FORC065_3676	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_3678	COG0484	heat shock protein binding
FORC065_3680	COG2271	Major facilitator Superfamily
FORC065_3683	COG1522	sequence-specific DNA binding
FORC065_3684	COG3706	GGDEF domain
FORC065_3685	COG4319	ketosteroid isomerase
FORC065_3686	COG1393	Belongs to the ArsC family
FORC065_3687	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FORC065_3691	COG2944	sequence-specific DNA binding
FORC065_3695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC065_3696	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC065_3697	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC065_3698	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC065_3699	COG4974	Belongs to the 'phage' integrase family
FORC065_3700	COG0716	FMN binding
FORC065_3701	COG4452	Inner membrane protein CreD
FORC065_3702	COG2205	protein histidine kinase activity
FORC065_3703	COG0745	RESPONSE REGULATOR receiver
FORC065_3706	COG0354	folic acid binding
FORC065_3707	COG1272	protein, Hemolysin III
FORC065_3709	COG1028	Short-chain dehydrogenase reductase Sdr
FORC065_3711	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC065_3711	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC065_3712	COG0509	glycine decarboxylation via glycine cleavage system
FORC065_3713	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FORC065_3714	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC065_3715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC065_3716	COG0006	proline dipeptidase activity
FORC065_3717	COG3079	Belongs to the UPF0149 family
FORC065_3718	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC065_3719	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC065_3720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC065_3721	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC065_3722	COG0583	DNA-binding transcription factor activity
FORC065_3724	COG1279	arginine transmembrane transporter activity
FORC065_3727	COG0191	fructose-bisphosphate aldolase activity
FORC065_3728	COG0126	phosphoglycerate kinase activity
FORC065_3729	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC065_3731	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC065_3732	COG0501	Belongs to the peptidase M48B family
FORC065_3735	COG1166	arginine decarboxylase activity
FORC065_3738	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC065_3741	COG0640	Transcriptional regulator
FORC065_3742	COG3091	SprT-like family
FORC065_3743	COG2356	endonuclease I
FORC065_3744	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC065_3745	COG0189	ligase activity
FORC065_3746	COG1678	Uncharacterized ACR, COG1678
FORC065_3747	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC065_3748	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC065_3750	COG2805	Type II/IV secretion system protein
FORC065_3751	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC065_3752	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC065_3753	COG0762	integral membrane protein
FORC065_3754	COG1872	DUF167
FORC065_3755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC065_3756	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC065_3759	COG3171	Protein conserved in bacteria
FORC065_3760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC065_3761	COG1194	a g-specific adenine glycosylase
FORC065_3762	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC065_3763	COG0741	lytic transglycosylase activity
FORC065_3768	COG0745	RESPONSE REGULATOR receiver
FORC065_3769	COG2205	protein histidine kinase activity
FORC065_3770	COG2197	response regulator
FORC065_3773	COG0531	amino acid
FORC065_3774	COG1982	Orn Lys Arg decarboxylase major
FORC065_3776	COG1289	transmembrane transporter activity
FORC065_3782	COG4604	ABC transporter, ATP-binding protein
FORC065_3783	COG4605	iron ion homeostasis
FORC065_3785	COG4607	ABC-type enterochelin transport system periplasmic component
FORC065_3788	COG0697	spore germination
FORC065_3792	COG0477	Major facilitator Superfamily
FORC065_3793	COG1609	Transcriptional regulator
FORC065_3795	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC065_3798	COG0477	Major facilitator Superfamily
FORC065_3804	COG5001	Diguanylate cyclase
FORC065_3807	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC065_3809	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FORC065_3810	COG0309	Hydrogenase expression formation protein (HypE)
FORC065_3811	COG0409	Hydrogenase expression formation protein
FORC065_3812	COG0298	carbon dioxide binding
FORC065_3813	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FORC065_3815	COG1773	rubredoxin
FORC065_3816	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FORC065_3817	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FORC065_3818	COG5557	Pfam Polysulphide reductase, NrfD
FORC065_3819	COG0437	4 iron, 4 sulfur cluster binding
FORC065_3820	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FORC065_3822	COG3133	Outer membrane lipoprotein
FORC065_3824	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC065_3825	COG1191	sigma factor activity
FORC065_3831	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC065_3833	COG3710	Transcriptional regulator
FORC065_3837	COG1256	bacterial-type flagellum assembly
FORC065_3839	COG1706	bacterial-type flagellum-dependent cell motility
FORC065_3841	COG4786	Flagellar basal body rod
FORC065_3843	COG1749	Flagellar hook protein flgE
FORC065_3844	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC065_3845	COG1558	bacterial-type flagellum-dependent cell motility
FORC065_3846	COG1815	bacterial-type flagellum-dependent cell motility
FORC065_3855	COG1677	Flagellar hook-basal body complex protein FliE
FORC065_3860	COG1987	bacterial-type flagellum assembly
FORC065_3866	COG0840	transmembrane signaling receptor activity
FORC065_3867	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC065_3870	COG4592	Periplasmic binding protein
FORC065_3871	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC065_3873	COG1120	ATPase activity
FORC065_3875	COG4774	siderophore transport
FORC065_3880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC065_3881	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC065_3887	COG4964	Belongs to the GSP D family
FORC065_3901	COG0848	biopolymer transport protein
FORC065_3904	COG0586	Pfam SNARE associated Golgi protein
FORC065_3907	COG1979	alcohol dehydrogenase
FORC065_3908	COG0656	L-ascorbic acid biosynthetic process
FORC065_3910	COG2132	Multicopper oxidase
FORC065_3912	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC065_3913	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC065_3914	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC065_3917	COG3150	esterase
FORC065_3918	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FORC065_3919	COG3151	Protein conserved in bacteria
FORC065_3920	COG0494	nUDIX hydrolase
FORC065_3922	COG1538	Outer membrane efflux protein
FORC065_3924	COG5463	Belongs to the UPF0441 family
FORC065_3925	COG0754	glutathionylspermidine amidase activity
FORC065_3926	COG3384	dioxygenase
FORC065_3927	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC065_3929	COG0531	amino acid
FORC065_3930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC065_3930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC065_3932	COG3025	triphosphatase activity
FORC065_3933	COG4991	sh3 domain protein
FORC065_3934	COG0617	tRNA 3'-terminal CCA addition
FORC065_3936	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC065_3937	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC065_3938	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC065_3939	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC065_3945	COG2003	Belongs to the UPF0758 family
FORC065_3949	COG2378	regulation of single-species biofilm formation
FORC065_3950	COG3596	GTP binding
FORC065_3951	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FORC065_3958	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FORC065_3967	COG3876	Protein conserved in bacteria
FORC065_3969	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC065_3971	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC065_3973	COG1263	PTS System
FORC065_3973	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_3975	COG0531	amino acid
FORC065_3976	COG0076	glutamate decarboxylase activity
FORC065_3978	COG2814	Major facilitator Superfamily
FORC065_3979	COG3247	response to pH
FORC065_3981	COG1902	pentaerythritol trinitrate reductase activity
FORC065_3981	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC065_3982	COG2813	Specifically methylates the guanine in position
FORC065_3986	COG0673	inositol 2-dehydrogenase activity
FORC065_3987	COG0861	Integral membrane protein TerC family
FORC065_3988	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC065_3990	COG2721	sulfolactate sulfo-lyase activity
FORC065_3991	COG0246	Mannitol dehydrogenase
FORC065_3992	COG1904	glucuronate isomerase
FORC065_3993	COG2271	Major facilitator Superfamily
FORC065_3996	COG0586	Pfam SNARE associated Golgi protein
FORC065_3999	COG4575	ribosome binding
FORC065_4000	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
FORC065_4002	COG2259	Doxx family
FORC065_4003	COG0435	Glutathione S-transferase
FORC065_4004	COG0583	DNA-binding transcription factor activity
FORC065_4005	COG1741	Belongs to the pirin family
FORC065_4007	COG0667	Aldo Keto reductase
FORC065_4010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC065_4012	COG0792	nuclease activity
FORC065_4013	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC065_4014	COG2823	Periplasmic or secreted lipoprotein
FORC065_4015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC065_4016	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC065_4017	COG0784	Response regulator, receiver
FORC065_4017	COG2198	Histidine kinase
FORC065_4017	COG5002	protein histidine kinase activity
FORC065_4018	COG1242	4 iron, 4 sulfur cluster binding
FORC065_4019	COG0067	glutamate synthase
FORC065_4019	COG0069	glutamate synthase activity
FORC065_4019	COG0070	glutamate synthase
FORC065_4020	COG0493	'glutamate synthase
FORC065_4022	COG2969	positive regulation of protein catabolic process
FORC065_4023	COG0625	glutathione transferase activity
FORC065_4025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC065_4026	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC065_4027	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC065_4028	COG3105	Protein conserved in bacteria
FORC065_4029	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC065_4030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC065_4031	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC065_4032	COG5007	Belongs to the BolA IbaG family
FORC065_4033	COG3113	response to antibiotic
FORC065_4034	COG2854	intermembrane phospholipid transfer
FORC065_4035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC065_4036	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC065_4037	COG1127	ABC transporter
FORC065_4038	COG1127	ABC transporter
FORC065_4040	COG0530	calcium, potassium:sodium antiporter activity
FORC065_4041	COG0517	IMP dehydrogenase activity
FORC065_4041	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC065_4042	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FORC065_4043	COG3117	lipopolysaccharide transmembrane transporter activity
FORC065_4044	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC065_4045	COG1137	ATPase activity
FORC065_4047	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FORC065_4050	COG1660	Displays ATPase and GTPase activities
FORC065_4051	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_4055	COG0540	Belongs to the ATCase OTCase family
FORC065_4056	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC065_4059	COG2308	Evidence 4 Homologs of previously reported genes of
FORC065_4064	COG0366	Alpha amylase catalytic
FORC065_4065	COG1263	PTS System
FORC065_4065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC065_4068	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FORC065_4071	COG3093	addiction module antidote protein HigA
FORC065_4072	COG3711	transcriptional antiterminator
FORC065_4072	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC065_4073	COG2706	6-phosphogluconolactonase activity
FORC065_4076	COG3964	amidohydrolase
FORC065_4082	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC065_4083	COG3783	Cytochrome b(562)
FORC065_4084	COG0312	modulator of DNA gyrase
FORC065_4085	COG3028	Belongs to the UPF0307 family
FORC065_4086	COG2732	(Barnase) inhibitor
FORC065_4090	COG1289	transmembrane transporter activity
FORC065_4091	COG1566	PFAM secretion protein HlyD family protein
FORC065_4093	COG0583	DNA-binding transcription factor activity
FORC065_4094	COG0312	modulator of DNA gyrase
FORC065_4095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC065_4096	COG3164	Protein of unknown function
FORC065_4097	COG1530	ribonuclease E activity
FORC065_4098	COG1530	ribonuclease E activity
FORC065_4099	COG0424	maF-like protein
FORC065_4100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC065_4101	COG1792	Involved in formation and maintenance of cell shape
FORC065_4102	COG1077	Cell shape determining protein MreB Mrl
FORC065_4103	COG2199	diguanylate cyclase activity
FORC065_4103	COG2200	EAL domain
FORC065_4104	COG0604	alcohol dehydrogenase
FORC065_4106	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FORC065_4107	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC065_4108	COG0511	ligase activity, forming carbon-carbon bonds
FORC065_4109	COG0439	Biotin carboxylase
FORC065_4110	COG3924	membrane
FORC065_4111	COG4145	pantothenate transmembrane transporter activity
FORC065_4112	COG2264	protein methyltransferase activity
FORC065_4113	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC065_4114	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC065_4116	COG3133	Outer membrane lipoprotein
FORC065_4117	COG1278	Cold shock
FORC065_4118	COG1278	Cold shock
FORC065_4119	COG1278	Cold shock
FORC065_4120	COG0471	metal ion transport
FORC065_4121	COG1560	Kdo2-lipid A biosynthetic process
FORC065_4123	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_4124	COG4597	amino acid ABC transporter
FORC065_4125	COG0765	amino acid transport
FORC065_4126	COG1126	abc transporter atp-binding protein
FORC065_4128	COG1380	Effector of murein hydrolase LrgA
FORC065_4129	COG0583	DNA-binding transcription factor activity
FORC065_4130	COG0025	NhaP-type Na H and K H
FORC065_4132	COG2252	PERMEase
FORC065_4135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC065_4136	COG2315	Protein conserved in bacteria
FORC065_4137	COG1448	Aminotransferase
FORC065_4142	COG2801	Transposase and inactivated derivatives
FORC065_4143	COG2963	transposase activity
FORC065_4145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC065_4146	COG0735	belongs to the Fur family
FORC065_4147	COG3237	CsbD-like
FORC065_4148	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC065_4149	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC065_4150	COG2937	Belongs to the GPAT DAPAT family
FORC065_4151	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC065_4152	COG3161	chorismate lyase activity
FORC065_4156	COG4580	involved in the transport of maltose and maltodextrins
FORC065_4158	COG2182	Extracellular solute-binding protein
FORC065_4159	COG1175	transmembrane transport
FORC065_4160	COG3833	ABC-type maltose transport systems, permease component
FORC065_4161	COG3223	Belongs to the PsiE family
FORC065_4162	COG0166	Belongs to the GPI family
FORC065_4163	COG0527	aspartate kinase activity
FORC065_4170	COG1414	Transcriptional regulator
FORC065_4171	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FORC065_4172	COG2224	Isocitrate lyase
FORC065_4173	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC065_4174	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC065_4176	COG0138	bifunctional purine biosynthesis protein purh
FORC065_4177	COG0151	Belongs to the GarS family
FORC065_4181	COG1515	deoxyribonuclease V activity
FORC065_4182	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC065_4183	COG2816	NAD+ diphosphatase activity
FORC065_4184	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC065_4187	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC065_4188	COG2104	thiamine diphosphate biosynthetic process
FORC065_4189	COG2022	thiamine diphosphate biosynthetic process
FORC065_4191	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC065_4192	COG0085	RNA polymerase activity
FORC065_4193	COG0222	ribosome binding
FORC065_4194	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC065_4195	COG0081	regulation of translation
FORC065_4196	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC065_4197	COG0250	Participates in transcription elongation, termination and antitermination
FORC065_4199	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC065_4201	COG1072	(Pantothenic acid kinase))
FORC065_4202	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FORC065_4202	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FORC065_4209	COG1739	Uncharacterized protein family UPF0029
FORC065_4211	COG1024	Enoyl-CoA hydratase
FORC065_4211	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC065_4212	COG0183	Belongs to the thiolase family
FORC065_4218	COG0805	protein transport
FORC065_4219	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC065_4220	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC065_4221	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC065_4223	COG2226	methyltransferase
FORC065_4224	COG1322	Protein conserved in bacteria
FORC065_4225	COG0586	Pfam SNARE associated Golgi protein
FORC065_4226	COG1966	Carbon starvation protein
FORC065_4229	COG0412	Dienelactone hydrolase
FORC065_4230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC065_4231	COG0583	DNA-binding transcription factor activity
FORC065_4235	COG0584	glycerophosphoryl diester phosphodiesterase
FORC065_4237	COG0395	ABC-type sugar transport system, permease component
FORC065_4238	COG1175	transmembrane transport
FORC065_4239	COG1653	transport
FORC065_4246	COG0410	ABC transporter
FORC065_4248	COG4177	L-phenylalanine transmembrane transporter activity
FORC065_4250	COG0683	leucine binding
FORC065_4253	COG2177	Part of the ABC transporter FtsEX involved in
FORC065_4254	COG2884	Cell division ATP-binding protein ftsE
FORC065_4255	COG0552	protein localization to endoplasmic reticulum
FORC065_4257	COG0742	ribosomal rna small subunit methyltransferase
FORC065_4258	COG3776	membrane
FORC065_4261	COG3714	YhhN family
FORC065_4262	COG2217	Heavy metal translocating P-type atpase
FORC065_4263	COG0425	Belongs to the sulfur carrier protein TusA family
FORC065_4264	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC065_4266	COG0247	lactate metabolic process
FORC065_4267	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
FORC065_4268	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC065_4270	COG2271	Major facilitator Superfamily
FORC065_4271	COG0584	glycerophosphoryl diester phosphodiesterase
FORC065_4272	COG0561	phosphatase activity
FORC065_4275	COG1280	lysine exporter protein (LysE YggA)
FORC065_4276	COG1280	lysine exporter protein (LysE YggA)
FORC065_4277	COG0514	ATP-dependent DNA helicase (RecQ)
FORC065_4278	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC065_4279	COG2050	protein possibly involved in aromatic compounds catabolism
FORC065_4284	COG5564	TIM-barrel signal transduction protein
FORC065_4285	COG5441	Belongs to the UPF0261 family
FORC065_4287	COG0210	DNA helicase
FORC065_4288	COG1011	Hydrolase
FORC065_4289	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC065_4290	COG3159	Protein conserved in bacteria
FORC065_4291	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC065_4293	COG1965	Belongs to the frataxin family
FORC065_4294	COG3072	Adenylate cyclase
FORC065_4297	COG0181	hydroxymethylbilane synthase activity
FORC065_4298	COG1587	Uroporphyrinogen-III synthase
FORC065_4299	COG2959	enzyme of heme biosynthesis
FORC065_4300	COG3071	HemY protein
FORC065_4305	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC065_4306	COG2244	polysaccharide biosynthetic process
FORC065_4307	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC065_4308	COG0456	acetyltransferase
FORC065_4309	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FORC065_4310	COG1088	dTDP-glucose 4,6-dehydratase activity
FORC065_4311	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FORC065_4312	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC065_4313	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FORC065_4316	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC065_4317	COG3118	belongs to the thioredoxin family
FORC065_4319	COG0248	Ppx GppA phosphatase
FORC065_4322	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC065_4327	COG3121	Chaperone
FORC065_4334	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC065_4335	COG0583	DNA-binding transcription factor activity
FORC065_4338	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORC065_4339	COG0129	dihydroxy-acid dehydratase activity
FORC065_4340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC065_4341	COG3978	acetolactate synthase activity
FORC065_4346	COG3085	chromosome segregation
FORC065_4347	COG0583	DNA-binding transcription factor activity
FORC065_4348	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_4351	COG1879	ABC-type sugar transport system periplasmic component
FORC065_4352	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC065_4354	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC065_4356	COG1309	transcriptional regulator
FORC065_4357	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC065_4359	COG0678	peroxiredoxin activity
FORC065_4359	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC065_4367	COG1629	transport
FORC065_4368	COG0165	Argininosuccinate lyase
FORC065_4369	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC065_4373	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC065_4375	COG0527	aspartate kinase activity
FORC065_4375	COG0460	homoserine dehydrogenase
FORC065_4376	COG0626	cystathionine gamma-synthase activity
FORC065_4377	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FORC065_4378	COG0254	rRNA binding
FORC065_4379	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC065_4380	COG1609	Transcriptional regulator
FORC065_4381	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC065_4382	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC065_4383	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC065_4384	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC065_4385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC065_4386	COG3074	FtsZ-dependent cytokinesis
FORC065_4388	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC065_4390	COG1494	fructose-1,6-bisphosphatase
FORC065_4391	COG2814	Major facilitator Superfamily
FORC065_4393	COG3152	Membrane
FORC065_4395	COG0149	triose-phosphate isomerase activity
FORC065_4397	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FORC065_4400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC065_4401	COG3678	ATP-independent chaperone mediated protein folding
FORC065_4402	COG0745	RESPONSE REGULATOR receiver
FORC065_4403	COG2205	protein histidine kinase activity
FORC065_4404	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC065_4404	COG2169	Transcriptional regulator
FORC065_4405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC065_4406	COG1045	serine acetyltransferase
FORC065_4407	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC065_4408	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC065_4409	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC065_4410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC065_4411	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC065_4413	COG2861	carbohydrate metabolic process
FORC065_4414	COG1063	alcohol dehydrogenase
FORC065_4415	COG0156	8-amino-7-oxononanoate synthase activity
FORC065_4416	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC065_4417	COG0859	PFAM glycosyl transferase family 9
FORC065_4418	COG0859	PFAM glycosyl transferase family 9
FORC065_4421	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC065_4422	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC065_4423	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FORC065_4424	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC065_4425	COG2003	Belongs to the UPF0758 family
FORC065_4426	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC065_4427	COG0756	dUTP diphosphatase activity
FORC065_4428	COG1309	transcriptional regulator
FORC065_4429	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC065_4430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC065_4431	COG1561	YicC-like family, N-terminal region
FORC065_4435	COG1024	Enoyl-CoA hydratase
FORC065_4438	COG2860	membrane
FORC065_4439	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC065_4441	COG1758	RNA polymerase activity
FORC065_4442	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC065_4443	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC065_4444	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC065_4445	COG0786	glutamate:sodium symporter activity
FORC065_4446	COG2233	PERMEase
FORC065_4447	COG2982	Protein involved in outer membrane biogenesis
FORC065_4449	COG3423	Transcriptional regulator
FORC065_4450	COG0456	acetyltransferase
FORC065_4451	COG1490	D-aminoacyl-tRNA deacylase activity
FORC065_4452	COG1295	ribonuclease BN
FORC065_4453	COG1011	Hydrolase
FORC065_4457	COG3852	Histidine kinase
FORC065_4459	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC065_4460	COG3078	GTPase activator activity
FORC065_4461	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC065_4462	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC065_4462	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC065_4464	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC065_4465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC065_4466	COG3084	Protein conserved in bacteria
FORC065_4468	COG1763	Mo-molybdopterin cofactor biosynthetic process
FORC065_4470	COG2186	Transcriptional regulator
FORC065_4471	COG0477	Major facilitator Superfamily
FORC065_4472	COG1609	Transcriptional regulator
FORC065_4473	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC065_4474	COG1879	ABC-type sugar transport system periplasmic component
FORC065_4475	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC065_4477	COG1869	D-ribose catabolic process
FORC065_4480	COG3158	transport of potassium into the cell
FORC065_4481	COG0714	Associated with various cellular activities
FORC065_4482	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC065_4484	COG2502	aspartate--ammonia ligase
FORC065_4485	COG1522	sequence-specific DNA binding
FORC065_4486	COG0716	FMN binding
FORC065_4488	COG0445	tRNA wobble uridine modification
FORC065_4489	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC065_4490	COG3312	ion transport
FORC065_4491	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC065_4493	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FORC065_4494	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC065_4495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC065_4496	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC065_4497	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC065_4498	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC065_4499	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC065_4501	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC065_4502	COG0573	inorganic phosphate transmembrane transporter activity
FORC065_4503	COG0581	inorganic phosphate transmembrane transporter activity
FORC065_4505	COG0704	Plays a role in the regulation of phosphate uptake
FORC065_4508	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC065_4510	COG0765	amino acid transport
FORC065_4511	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC065_4512	COG2252	PERMEase
FORC065_4514	COG4566	intracellular signal transduction
FORC065_4515	COG4191	Histidine kinase
FORC065_4516	COG0431	NADPH-dependent FMN reductase
FORC065_4517	COG0840	transmembrane signaling receptor activity
FORC065_4518	COG2011	ABC-type metal ion transport system permease component
FORC065_4521	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC065_4522	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC065_4523	COG0706	membrane insertase activity
FORC065_4524	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FORC065_4525	COG0594	ribonuclease P activity
FORC065_4527	COG0230	Belongs to the bacterial ribosomal protein bL34 family