locus-tag	class	description
FORC2_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC2_0002	COG0592	DNA-directed DNA polymerase activity
FORC2_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC2_0004	COG0187	DNA topoisomerase II activity
FORC2_0005	COG0561	phosphatase activity
FORC2_0006	COG1940	carbohydrate kinase activity
FORC2_0007	COG2423	ornithine cyclodeaminase activity
FORC2_0008	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORC2_0009	COG0823	Involved in the tonB-independent uptake of proteins
FORC2_0010	COG5645	(Lipo)protein
FORC2_0013	COG0569	domain protein
FORC2_0013	COG2985	domain, Protein
FORC2_0014	COG3977	Valine--pyruvate aminotransferase
FORC2_0015	COG0366	Alpha amylase catalytic
FORC2_0016	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC2_0019	COG2885	chlorophyll binding
FORC2_0023	COG2818	Glycosylase
FORC2_0024	COG0752	glycyl-tRNA synthetase alpha subunit
FORC2_0025	COG0751	glycine-tRNA ligase activity
FORC2_0027	COG2213	PTS system mannitol-specific
FORC2_0027	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_0028	COG0246	Mannitol dehydrogenase
FORC2_0029	COG3722	fumarate hydratase activity
FORC2_0031	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC2_0035	COG2258	MOSC domain
FORC2_0036	COG0840	transmembrane signaling receptor activity
FORC2_0037	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FORC2_0038	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC2_0039	COG3383	formate dehydrogenase (NAD+) activity
FORC2_0039	COG0243	molybdopterin cofactor binding
FORC2_0040	COG0243	molybdopterin cofactor binding
FORC2_0040	COG3383	formate dehydrogenase (NAD+) activity
FORC2_0041	COG0437	4 iron, 4 sulfur cluster binding
FORC2_0042	COG2864	formate dehydrogenase
FORC2_0043	COG3058	Necessary for formate dehydrogenase activity
FORC2_0044	COG1921	L-seryl-tRNASec selenium transferase activity
FORC2_0045	COG3276	selenocysteine insertion sequence binding
FORC2_0047	COG3274	enterobacterial common antigen metabolic process
FORC2_0050	COG3121	Chaperone
FORC2_0051	COG1070	Carbohydrate kinase
FORC2_0052	COG2115	Belongs to the xylose isomerase family
FORC2_0053	COG4213	ABC transporter substrate-binding protein
FORC2_0055	COG4214	carbohydrate transport
FORC2_0056	COG1609	Transcriptional regulator
FORC2_0056	COG2207	Transcriptional regulator
FORC2_0057	COG0582	viral genome integration into host DNA
FORC2_0068	COG1609	Transcriptional regulator
FORC2_0069	COG1940	carbohydrate kinase activity
FORC2_0070	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC2_0071	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC2_0072	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC2_0073	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC2_0076	COG2723	6-phospho-beta-galactosidase activity
FORC2_0077	COG1482	cell wall glycoprotein biosynthetic process
FORC2_0080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC2_0081	COG2986	histidine ammonia-lyase
FORC2_0084	COG1764	response to oxidative stress
FORC2_0085	COG2194	sulfuric ester hydrolase activity
FORC2_0086	COG2197	response regulator
FORC2_0087	COG3851	Histidine kinase
FORC2_0088	COG2271	Major facilitator Superfamily
FORC2_0089	COG3210	domain, Protein
FORC2_0090	COG2831	hemolysin activation secretion protein
FORC2_0091	COG3210	domain, Protein
FORC2_0092	COG0747	negative chemotaxis
FORC2_0093	COG0601	transmembrane transport
FORC2_0094	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC2_0095	COG0444	Belongs to the ABC transporter superfamily
FORC2_0096	COG4608	Belongs to the ABC transporter superfamily
FORC2_0097	COG2194	sulfuric ester hydrolase activity
FORC2_0101	COG1192	Involved in chromosome partitioning
FORC2_0104	COG1215	transferase activity, transferring glycosyl groups
FORC2_0105	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FORC2_0106	COG0457	Tetratricopeptide repeat
FORC2_0106	COG3118	belongs to the thioredoxin family
FORC2_0107	COG2200	EAL domain
FORC2_0107	COG2199	diguanylate cyclase activity
FORC2_0108	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC2_0111	COG1301	dicarboxylic acid transport
FORC2_0112	COG0612	Peptidase, M16
FORC2_0113	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC2_0114	COG1942	4-Oxalocrotonate Tautomerase
FORC2_0115	COG2200	EAL domain
FORC2_0116	COG2982	Protein involved in outer membrane biogenesis
FORC2_0117	COG2134	cdp-diacylglycerol pyrophosphatase
FORC2_0118	COG1295	ribonuclease BN
FORC2_0129	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC2_0138	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC2_0139	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC2_0141	COG0742	ribosomal rna small subunit methyltransferase
FORC2_0144	COG0589	response to stress
FORC2_0146	COG0306	phosphate transporter
FORC2_0147	COG2081	HI0933 family
FORC2_0148	COG1301	dicarboxylic acid transport
FORC2_0151	COG3799	methylaspartate ammonia-lyase activity
FORC2_0152	COG4865	methylaspartate mutase activity
FORC2_0154	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC2_0156	COG1648	precorrin-2 dehydrogenase activity
FORC2_0156	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC2_0157	COG0583	DNA-binding transcription factor activity
FORC2_0158	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC2_0158	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC2_0160	COG0561	phosphatase activity
FORC2_0162	COG0583	DNA-binding transcription factor activity
FORC2_0163	COG2814	Major facilitator Superfamily
FORC2_0166	COG3718	enzyme involved in inositol metabolism
FORC2_0168	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC2_0170	COG0673	inositol 2-dehydrogenase activity
FORC2_0171	COG1082	Xylose isomerase domain protein TIM barrel
FORC2_0172	COG1247	-acetyltransferase
FORC2_0173	COG1741	Belongs to the pirin family
FORC2_0174	COG1609	Transcriptional regulator
FORC2_0175	COG2610	gluconate transmembrane transporter activity
FORC2_0176	COG3265	gluconokinase activity
FORC2_0177	COG2095	MarC family integral membrane protein
FORC2_0178	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC2_0182	COG3275	phosphorelay sensor kinase activity
FORC2_0183	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC2_0184	COG1523	belongs to the glycosyl hydrolase 13 family
FORC2_0186	COG0297	glycogen (starch) synthase activity
FORC2_0187	COG0058	SHG alpha-glucan phosphorylase activity
FORC2_0188	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC2_0189	COG1349	DNA-binding transcription factor activity
FORC2_0190	COG0705	Rhomboid family
FORC2_0193	COG2909	trisaccharide binding
FORC2_0194	COG0058	SHG alpha-glucan phosphorylase activity
FORC2_0195	COG1640	4-alpha-glucanotransferase
FORC2_0196	COG0316	Belongs to the HesB IscA family
FORC2_0196	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC2_0198	COG0596	Alpha beta hydrolase
FORC2_0201	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FORC2_0202	COG1918	ferrous iron import across plasma membrane
FORC2_0203	COG2183	response to ionizing radiation
FORC2_0204	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC2_0205	COG0745	RESPONSE REGULATOR receiver
FORC2_0207	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC2_0209	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC2_0210	COG1011	Hydrolase
FORC2_0212	COG0494	nUDIX hydrolase
FORC2_0213	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC2_0218	COG4796	Type ii and iii secretion system protein
FORC2_0219	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC2_0223	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC2_0225	COG0180	Tryptophanyl-tRNA synthetase
FORC2_0226	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC2_0226	COG1648	precorrin-2 dehydrogenase activity
FORC2_0228	COG2146	nitrite reductase [NAD(P)H] activity
FORC2_0229	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC2_0230	COG0402	S-adenosylhomocysteine deaminase activity
FORC2_0231	COG0738	Major facilitator superfamily
FORC2_0233	COG1486	melibiose metabolic process
FORC2_0234	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC2_0235	COG0433	COG0433 Predicted ATPase
FORC2_0238	COG1289	transmembrane transporter activity
FORC2_0240	COG1765	OsmC-like protein
FORC2_0241	COG3954	Phosphoribulokinase
FORC2_0242	COG3089	Belongs to the UPF0270 family
FORC2_0243	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC2_0246	COG4521	taurine ABC transporter
FORC2_0248	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC2_0249	COG2175	clavaminate synthase activity
FORC2_0251	COG1216	Glycosyl transferase, family 2
FORC2_0252	COG0488	(ABC) transporter
FORC2_0253	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC2_0255	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FORC2_0256	COG1047	Peptidyl-prolyl cis-trans
FORC2_0257	COG2900	Belongs to the SlyX family
FORC2_0258	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC2_0259	COG2964	Protein conserved in bacteria
FORC2_0260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC2_0261	COG2923	Belongs to the DsrF TusC family
FORC2_0262	COG2168	tRNA wobble position uridine thiolation
FORC2_0263	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FORC2_0264	COG0049	tRNA binding
FORC2_0266	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC2_0269	COG0051	transcription antitermination factor activity, RNA binding
FORC2_0270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC2_0271	COG0088	Forms part of the polypeptide exit tunnel
FORC2_0272	COG0089	rRNA binding
FORC2_0273	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC2_0274	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC2_0275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC2_0276	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC2_0277	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FORC2_0278	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC2_0279	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC2_0280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC2_0281	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC2_0282	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC2_0283	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC2_0285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC2_0286	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FORC2_0288	COG1841	ribosomal large subunit assembly
FORC2_0289	COG0200	Binds to the 23S rRNA
FORC2_0290	COG0201	protein transport
FORC2_0291	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC2_0292	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC2_0293	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC2_0294	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FORC2_0295	COG0202	RNA polymerase activity
FORC2_0296	COG0203	ribosomal protein L17
FORC2_0298	COG0789	Transcriptional regulator
FORC2_0299	COG3036	rescue of stalled ribosome
FORC2_0300	COG1970	mechanosensitive ion channel activity
FORC2_0301	COG0569	domain protein
FORC2_0302	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC2_0302	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC2_0303	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC2_0304	COG0242	peptide deformylase activity
FORC2_0305	COG0758	DNA mediated transformation
FORC2_0307	COG0551	DNA topoisomerase type I activity
FORC2_0308	COG0009	L-threonylcarbamoyladenylate synthase
FORC2_0309	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC2_0310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC2_0311	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC2_0312	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC2_0314	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
FORC2_0315	COG1414	Transcriptional regulator
FORC2_0320	COG0527	aspartate kinase activity
FORC2_0321	COG0166	Belongs to the GPI family
FORC2_0322	COG3223	Belongs to the PsiE family
FORC2_0323	COG3833	ABC-type maltose transport systems, permease component
FORC2_0324	COG1175	transmembrane transport
FORC2_0325	COG2182	Extracellular solute-binding protein
FORC2_0327	COG4580	involved in the transport of maltose and maltodextrins
FORC2_0329	COG3161	chorismate lyase activity
FORC2_0330	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC2_0331	COG2937	Belongs to the GPAT DAPAT family
FORC2_0332	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC2_0333	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC2_0334	COG3237	CsbD-like
FORC2_0335	COG0735	belongs to the Fur family
FORC2_0336	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC2_0340	COG0305	Participates in initiation and elongation during chromosome replication
FORC2_0341	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC2_0342	COG1448	Aminotransferase
FORC2_0343	COG2315	Protein conserved in bacteria
FORC2_0344	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC2_0347	COG2252	PERMEase
FORC2_0348	COG0025	NhaP-type Na H and K H
FORC2_0349	COG0583	DNA-binding transcription factor activity
FORC2_0350	COG1380	Effector of murein hydrolase LrgA
FORC2_0352	COG1126	abc transporter atp-binding protein
FORC2_0353	COG0765	amino acid transport
FORC2_0354	COG4597	amino acid ABC transporter
FORC2_0355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_0357	COG1560	Kdo2-lipid A biosynthetic process
FORC2_0358	COG0471	metal ion transport
FORC2_0359	COG1278	Cold shock
FORC2_0360	COG1278	Cold shock
FORC2_0361	COG1278	Cold shock
FORC2_0362	COG3133	Outer membrane lipoprotein
FORC2_0363	COG3706	GGDEF domain
FORC2_0363	COG0745	RESPONSE REGULATOR receiver
FORC2_0364	COG0582	viral genome integration into host DNA
FORC2_0382	COG1802	Transcriptional regulator
FORC2_0382	COG4626	Terminase
FORC2_0385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC2_0386	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC2_0387	COG2264	protein methyltransferase activity
FORC2_0388	COG4145	pantothenate transmembrane transporter activity
FORC2_0389	COG3924	membrane
FORC2_0390	COG0439	Biotin carboxylase
FORC2_0391	COG0511	ligase activity, forming carbon-carbon bonds
FORC2_0392	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC2_0393	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FORC2_0395	COG0604	alcohol dehydrogenase
FORC2_0396	COG2200	EAL domain
FORC2_0396	COG2199	diguanylate cyclase activity
FORC2_0397	COG1077	Cell shape determining protein MreB Mrl
FORC2_0398	COG1792	Involved in formation and maintenance of cell shape
FORC2_0399	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC2_0401	COG1530	ribonuclease E activity
FORC2_0402	COG3164	Protein of unknown function
FORC2_0403	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC2_0404	COG0312	modulator of DNA gyrase
FORC2_0411	COG0583	DNA-binding transcription factor activity
FORC2_0413	COG1566	PFAM secretion protein HlyD family protein
FORC2_0414	COG1289	transmembrane transporter activity
FORC2_0417	COG2732	(Barnase) inhibitor
FORC2_0418	COG3028	Belongs to the UPF0307 family
FORC2_0419	COG0312	modulator of DNA gyrase
FORC2_0420	COG3783	Cytochrome b(562)
FORC2_0421	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC2_0427	COG3964	amidohydrolase
FORC2_0431	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_0431	COG3711	transcriptional antiterminator
FORC2_0432	COG3093	addiction module antidote protein HigA
FORC2_0434	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FORC2_0436	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_0436	COG1263	PTS System
FORC2_0437	COG0366	Alpha amylase catalytic
FORC2_0441	COG2308	Evidence 4 Homologs of previously reported genes of
FORC2_0443	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC2_0444	COG0540	Belongs to the ATCase OTCase family
FORC2_0445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_0446	COG1660	Displays ATPase and GTPase activities
FORC2_0447	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_0449	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FORC2_0450	COG1137	ATPase activity
FORC2_0451	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC2_0452	COG3117	lipopolysaccharide transmembrane transporter activity
FORC2_0453	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FORC2_0454	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC2_0454	COG0517	IMP dehydrogenase activity
FORC2_0455	COG0530	calcium, potassium:sodium antiporter activity
FORC2_0456	COG1127	ABC transporter
FORC2_0457	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC2_0458	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC2_0459	COG2854	intermembrane phospholipid transfer
FORC2_0460	COG3113	response to antibiotic
FORC2_0461	COG5007	Belongs to the BolA IbaG family
FORC2_0462	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC2_0463	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC2_0464	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC2_0465	COG3105	Protein conserved in bacteria
FORC2_0466	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC2_0467	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC2_0468	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC2_0469	COG0625	glutathione transferase activity
FORC2_0470	COG2969	positive regulation of protein catabolic process
FORC2_0472	COG0493	'glutamate synthase
FORC2_0473	COG0070	glutamate synthase
FORC2_0473	COG0067	glutamate synthase
FORC2_0473	COG0069	glutamate synthase activity
FORC2_0474	COG1242	4 iron, 4 sulfur cluster binding
FORC2_0475	COG2198	Histidine kinase
FORC2_0475	COG0784	Response regulator, receiver
FORC2_0475	COG5002	protein histidine kinase activity
FORC2_0476	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC2_0477	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC2_0478	COG2823	Periplasmic or secreted lipoprotein
FORC2_0479	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC2_0480	COG0792	nuclease activity
FORC2_0482	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC2_0494	COG0667	Aldo Keto reductase
FORC2_0495	COG1064	alcohol dehydrogenase
FORC2_0496	COG1741	Belongs to the pirin family
FORC2_0497	COG0583	DNA-binding transcription factor activity
FORC2_0498	COG0435	Glutathione S-transferase
FORC2_0499	COG2259	Doxx family
FORC2_0501	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
FORC2_0502	COG4575	ribosome binding
FORC2_0505	COG0586	Pfam SNARE associated Golgi protein
FORC2_0508	COG2271	Major facilitator Superfamily
FORC2_0509	COG1904	glucuronate isomerase
FORC2_0510	COG0246	Mannitol dehydrogenase
FORC2_0511	COG2721	sulfolactate sulfo-lyase activity
FORC2_0513	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC2_0514	COG0861	Integral membrane protein TerC family
FORC2_0515	COG0673	inositol 2-dehydrogenase activity
FORC2_0516	COG1451	nucleotide metabolic process
FORC2_0518	COG2813	Specifically methylates the guanine in position
FORC2_0519	COG1902	pentaerythritol trinitrate reductase activity
FORC2_0519	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC2_0521	COG3247	response to pH
FORC2_0522	COG2814	Major facilitator Superfamily
FORC2_0524	COG0076	glutamate decarboxylase activity
FORC2_0525	COG0531	amino acid
FORC2_0526	COG2066	Belongs to the glutaminase family
FORC2_0527	COG1263	PTS System
FORC2_0527	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_0528	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC2_0530	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC2_0532	COG3876	Protein conserved in bacteria
FORC2_0537	COG4983	Phage plasmid primase, P4 family domain protein
FORC2_0545	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC2_0546	COG0542	response to heat
FORC2_0548	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC2_0557	COG0501	Belongs to the peptidase M48B family
FORC2_0558	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC2_0559	COG3596	GTP binding
FORC2_0561	COG2378	regulation of single-species biofilm formation
FORC2_0566	COG2003	Belongs to the UPF0758 family
FORC2_0570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC2_0571	COG0358	DNA primase activity
FORC2_0573	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC2_0574	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC2_0575	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC2_0576	COG1968	undecaprenyl-diphosphatase activity
FORC2_0577	COG0617	tRNA 3'-terminal CCA addition
FORC2_0578	COG4991	sh3 domain protein
FORC2_0579	COG3025	triphosphatase activity
FORC2_0580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC2_0581	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC2_0581	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC2_0582	COG0531	amino acid
FORC2_0584	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC2_0585	COG3384	dioxygenase
FORC2_0586	COG0754	glutathionylspermidine amidase activity
FORC2_0587	COG5463	Belongs to the UPF0441 family
FORC2_0588	COG1538	Outer membrane efflux protein
FORC2_0589	COG0494	nUDIX hydrolase
FORC2_0590	COG3151	Protein conserved in bacteria
FORC2_0591	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FORC2_0592	COG3150	esterase
FORC2_0593	COG0187	DNA topoisomerase II activity
FORC2_0595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC2_0596	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC2_0597	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC2_0598	COG0204	Acyl-transferase
FORC2_0599	COG2132	Multicopper oxidase
FORC2_0602	COG0656	L-ascorbic acid biosynthetic process
FORC2_0603	COG1979	alcohol dehydrogenase
FORC2_0604	COG2207	Transcriptional regulator
FORC2_0605	COG0586	Pfam SNARE associated Golgi protein
FORC2_0607	COG0811	peptide transport
FORC2_0608	COG0848	biopolymer transport protein
FORC2_0618	COG4964	Belongs to the GSP D family
FORC2_0624	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC2_0625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_0629	COG4774	siderophore transport
FORC2_0631	COG1120	ATPase activity
FORC2_0632	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC2_0633	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC2_0634	COG4592	Periplasmic binding protein
FORC2_0635	COG2271	Major facilitator Superfamily
FORC2_0636	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC2_0637	COG0840	transmembrane signaling receptor activity
FORC2_0641	COG3133	Outer membrane lipoprotein
FORC2_0642	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FORC2_0643	COG0437	4 iron, 4 sulfur cluster binding
FORC2_0644	COG5557	Pfam Polysulphide reductase, NrfD
FORC2_0645	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FORC2_0646	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FORC2_0647	COG1773	rubredoxin
FORC2_0648	COG0375	protein maturation
FORC2_0649	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FORC2_0650	COG0298	carbon dioxide binding
FORC2_0651	COG0409	Hydrogenase expression formation protein
FORC2_0652	COG0309	Hydrogenase expression formation protein (HypE)
FORC2_0653	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FORC2_0654	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC2_0657	COG5001	Diguanylate cyclase
FORC2_0660	COG2197	response regulator
FORC2_0662	COG0477	Major facilitator Superfamily
FORC2_0665	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC2_0667	COG1609	Transcriptional regulator
FORC2_0668	COG0477	Major facilitator Superfamily
FORC2_0670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC2_0671	COG0697	spore germination
FORC2_0674	COG4607	ABC-type enterochelin transport system periplasmic component
FORC2_0676	COG4605	iron ion homeostasis
FORC2_0677	COG4604	ABC transporter, ATP-binding protein
FORC2_0678	COG0024	Methionine aminopeptidase
FORC2_0683	COG1289	transmembrane transporter activity
FORC2_0685	COG1982	Orn Lys Arg decarboxylase major
FORC2_0686	COG0531	amino acid
FORC2_0690	COG2197	response regulator
FORC2_0691	COG2205	protein histidine kinase activity
FORC2_0693	COG0745	RESPONSE REGULATOR receiver
FORC2_0695	COG1982	Orn Lys Arg decarboxylase major
FORC2_0697	COG0741	lytic transglycosylase activity
FORC2_0698	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC2_0699	COG1194	a g-specific adenine glycosylase
FORC2_0700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC2_0701	COG3171	Protein conserved in bacteria
FORC2_0702	COG2066	Belongs to the glutaminase family
FORC2_0704	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC2_0705	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC2_0706	COG1872	DUF167
FORC2_0707	COG0762	integral membrane protein
FORC2_0708	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC2_0709	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC2_0710	COG2805	Type II/IV secretion system protein
FORC2_0712	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC2_0713	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC2_0714	COG1678	Uncharacterized ACR, COG1678
FORC2_0715	COG0189	ligase activity
FORC2_0716	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC2_0717	COG2356	endonuclease I
FORC2_0718	COG3091	SprT-like family
FORC2_0719	COG0640	Transcriptional regulator
FORC2_0722	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC2_0723	COG1166	arginine decarboxylase activity
FORC2_0725	COG0501	Belongs to the peptidase M48B family
FORC2_0726	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC2_0727	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC2_0728	COG0126	phosphoglycerate kinase activity
FORC2_0729	COG0191	fructose-bisphosphate aldolase activity
FORC2_0731	COG1279	arginine transmembrane transporter activity
FORC2_0733	COG0583	DNA-binding transcription factor activity
FORC2_0734	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC2_0735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC2_0736	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC2_0737	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC2_0738	COG3079	Belongs to the UPF0149 family
FORC2_0739	COG0006	proline dipeptidase activity
FORC2_0740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC2_0741	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC2_0742	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FORC2_0743	COG0509	glycine decarboxylation via glycine cleavage system
FORC2_0744	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC2_0744	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC2_0746	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_0748	COG1272	protein, Hemolysin III
FORC2_0749	COG0354	folic acid binding
FORC2_0750	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC2_0752	COG0745	RESPONSE REGULATOR receiver
FORC2_0753	COG2205	protein histidine kinase activity
FORC2_0754	COG4452	Inner membrane protein CreD
FORC2_0755	COG0716	FMN binding
FORC2_0756	COG4974	Belongs to the 'phage' integrase family
FORC2_0757	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC2_0758	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC2_0759	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC2_0760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC2_0761	COG0582	viral genome integration into host DNA
FORC2_0788	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FORC2_0789	COG1393	Belongs to the ArsC family
FORC2_0790	COG4319	ketosteroid isomerase
FORC2_0791	COG3706	GGDEF domain
FORC2_0792	COG1522	sequence-specific DNA binding
FORC2_0795	COG2271	Major facilitator Superfamily
FORC2_0797	COG0484	heat shock protein binding
FORC2_0799	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_0800	COG1733	regulation of RNA biosynthetic process
FORC2_0801	COG0288	reversible hydration of carbon dioxide
FORC2_0807	COG2165	general secretion pathway protein
FORC2_0813	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FORC2_0817	COG0840	transmembrane signaling receptor activity
FORC2_0821	COG2814	Major facilitator Superfamily
FORC2_0822	COG0583	DNA-binding transcription factor activity
FORC2_0823	COG0019	diaminopimelate decarboxylase activity
FORC2_0824	COG1609	Transcriptional regulator
FORC2_0826	COG0318	PFAM AMP-dependent synthetase and ligase
FORC2_0826	COG0204	Acyl-transferase
FORC2_0827	COG0477	Major facilitator Superfamily
FORC2_0828	COG0667	Aldo Keto reductase
FORC2_0829	COG0861	Integral membrane protein TerC family
FORC2_0830	COG3066	DNA modification
FORC2_0832	COG1051	belongs to the nudix hydrolase family
FORC2_0834	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC2_0835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC2_0840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC2_0841	COG1025	Belongs to the peptidase M16 family
FORC2_0842	COG1074	ATP-dependent DNA helicase activity
FORC2_0843	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC2_0844	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC2_0844	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC2_0845	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC2_0846	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC2_0847	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC2_0848	COG2166	iron-sulfur cluster assembly
FORC2_0849	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC2_0851	COG0583	DNA-binding transcription factor activity
FORC2_0852	COG2363	Small membrane protein
FORC2_0853	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC2_0854	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC2_0855	COG1611	Belongs to the LOG family
FORC2_0856	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC2_0856	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC2_0858	COG3098	single-species biofilm formation
FORC2_0859	COG0564	pseudouridine synthase activity
FORC2_0862	COG2171	N-acyltransferase activity
FORC2_0863	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC2_0864	COG0024	Methionine aminopeptidase
FORC2_0866	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC2_0867	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC2_0868	COG0528	UMP kinase activity
FORC2_0869	COG0233	cytoplasmic translational termination
FORC2_0870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC2_0871	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC2_0872	COG0575	Belongs to the CDS family
FORC2_0873	COG0750	zinc metalloprotease
FORC2_0875	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC2_0876	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC2_0877	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC2_0878	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC2_0879	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC2_0880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC2_0881	COG0587	DNA-directed DNA polymerase activity
FORC2_0882	COG0825	malonyl-CoA metabolic process
FORC2_0884	COG0346	lactoylglutathione lyase activity
FORC2_0885	COG0037	tRNA processing
FORC2_0887	COG4568	rho-dependent transcription termination
FORC2_0889	COG4681	YaeQ
FORC2_0891	COG3015	lipoprotein NlpE involved in copper resistance
FORC2_0892	COG0442	prolyl-tRNA aminoacylation
FORC2_0893	COG1720	tRNA m6t6A37 methyltransferase activity
FORC2_0895	COG1464	Belongs to the NlpA lipoprotein family
FORC2_0896	COG2011	ABC-type metal ion transport system permease component
FORC2_0898	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC2_0904	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC2_0907	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC2_0915	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_0917	COG0656	L-ascorbic acid biosynthetic process
FORC2_0918	COG0583	DNA-binding transcription factor activity
FORC2_0919	COG2814	Major facilitator Superfamily
FORC2_0920	COG3021	interspecies interaction between organisms
FORC2_0921	COG1388	LysM domain
FORC2_0921	COG0741	lytic transglycosylase activity
FORC2_0922	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC2_0923	COG2226	methyltransferase
FORC2_0924	COG0328	RNA-DNA hybrid ribonuclease activity
FORC2_0925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC2_0926	COG2113	Glycine betaine
FORC2_0927	COG4176	ABC-type proline glycine betaine transport system permease component
FORC2_0928	COG4175	Glycine betaine
FORC2_0929	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC2_0931	COG1780	Probably involved in ribonucleotide reductase function
FORC2_0932	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC2_0933	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC2_0935	COG4575	ribosome binding
FORC2_0938	COG2207	Transcriptional regulator
FORC2_0939	COG0477	Major facilitator Superfamily
FORC2_0943	COG1278	Cold shock
FORC2_0950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC2_0951	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC2_0956	COG0804	urea catabolic process
FORC2_0957	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FORC2_0958	COG0830	nickel cation binding
FORC2_0959	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FORC2_0960	COG0829	nickel cation binding
FORC2_0961	COG4413	Urea transporter
FORC2_0962	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
FORC2_0964	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC2_0965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC2_0967	COG2133	pyrroloquinoline quinone binding
FORC2_0968	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC2_0969	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC2_0970	COG2723	6-phospho-beta-galactosidase activity
FORC2_0971	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC2_0972	COG1917	Cupin 2, conserved barrel domain protein
FORC2_0972	COG2169	Transcriptional regulator
FORC2_0973	COG3394	polysaccharide catabolic process
FORC2_0974	COG0659	secondary active sulfate transmembrane transporter activity
FORC2_0983	COG2826	transposase and inactivated derivatives, IS30 family
FORC2_0987	COG3547	Transposase (IS116 IS110 IS902 family)
FORC2_0988	COG1063	alcohol dehydrogenase
FORC2_0992	COG1902	pentaerythritol trinitrate reductase activity
FORC2_0996	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FORC2_0998	COG2826	transposase and inactivated derivatives, IS30 family
FORC2_1011	COG0582	viral genome integration into host DNA
FORC2_1012	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC2_1013	COG2867	negative regulation of translational initiation
FORC2_1015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC2_1016	COG0497	DNA recombination
FORC2_1017	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC2_1018	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC2_1019	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC2_1020	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC2_1023	COG0513	Belongs to the DEAD box helicase family
FORC2_1024	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC2_1025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC2_1027	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC2_1029	COG3086	response to oxidative stress
FORC2_1031	COG0481	GTPase activity
FORC2_1032	COG0681	Belongs to the peptidase S26 family
FORC2_1033	COG0571	ribonuclease III activity
FORC2_1034	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC2_1035	COG1381	Involved in DNA repair and RecF pathway recombination
FORC2_1036	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC2_1037	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC2_1039	COG2610	gluconate transmembrane transporter activity
FORC2_1040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC2_1041	COG1737	Transcriptional regulator
FORC2_1043	COG0560	Phosphoserine phosphatase
FORC2_1045	COG0590	tRNA wobble adenosine to inosine editing
FORC2_1046	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC2_1049	COG2205	protein histidine kinase activity
FORC2_1050	COG3170	Tfp pilus assembly protein FimV
FORC2_1051	COG2204	response regulator
FORC2_1052	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC2_1052	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC2_1053	COG0347	Belongs to the P(II) protein family
FORC2_1056	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FORC2_1057	COG3457	Alanine racemase
FORC2_1059	COG2188	Transcriptional regulator
FORC2_1060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC2_1060	COG1017	nitric oxide dioxygenase activity
FORC2_1061	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC2_1062	COG2814	Major facilitator Superfamily
FORC2_1063	COG3711	transcriptional antiterminator
FORC2_1064	COG3683	transport system, periplasmic component
FORC2_1065	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FORC2_1066	COG0483	inositol monophosphate 1-phosphatase activity
FORC2_1067	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FORC2_1068	COG1959	2 iron, 2 sulfur cluster binding
FORC2_1070	COG0822	iron-sulfur transferase activity
FORC2_1071	COG0316	Belongs to the HesB IscA family
FORC2_1072	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC2_1073	COG0443	Heat shock 70 kDa protein
FORC2_1074	COG0633	Ferredoxin
FORC2_1075	COG2975	iron-sulfur cluster assembly
FORC2_1078	COG3468	outer membrane autotransporter barrel domain protein
FORC2_1079	COG3468	outer membrane autotransporter barrel domain protein
FORC2_1080	COG2373	Large extracellular alpha-helical protein
FORC2_1081	COG4953	penicillin-binding protein 1C
FORC2_1083	COG0105	UTP biosynthetic process
FORC2_1084	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC2_1086	COG1426	Protein conserved in bacteria
FORC2_1087	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC2_1088	COG0124	histidyl-tRNA synthetase
FORC2_1089	COG2976	Protein conserved in bacteria
FORC2_1090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC2_1092	COG1160	GTP binding
FORC2_1094	COG1645	bacterial-type flagellum-dependent swarming motility
FORC2_1095	COG1570	exodeoxyribonuclease VII activity
FORC2_1096	COG0517	IMP dehydrogenase activity
FORC2_1096	COG0516	GMP reductase activity
FORC2_1097	COG0519	Catalyzes the synthesis of GMP from XMP
FORC2_1097	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC2_1104	COG0351	phosphomethylpyrimidine kinase
FORC2_1108	COG1349	DNA-binding transcription factor activity
FORC2_1109	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_1110	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_1113	COG3730	PTS system glucitol sorbitol-specific
FORC2_1114	COG1597	lipid kinase activity
FORC2_1118	COG3422	double-strand break repair
FORC2_1119	COG0745	RESPONSE REGULATOR receiver
FORC2_1120	COG2205	protein histidine kinase activity
FORC2_1121	COG0477	Major facilitator Superfamily
FORC2_1123	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC2_1125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_1126	COG0443	Heat shock 70 kDa protein
FORC2_1127	COG5001	Diguanylate cyclase
FORC2_1127	COG3447	MASE1 domain protein
FORC2_1127	COG5002	protein histidine kinase activity
FORC2_1128	COG2239	Acts as a magnesium transporter
FORC2_1130	COG0248	Ppx GppA phosphatase
FORC2_1131	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC2_1132	COG0573	inorganic phosphate transmembrane transporter activity
FORC2_1133	COG0581	inorganic phosphate transmembrane transporter activity
FORC2_1137	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC2_1138	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC2_1139	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC2_1140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC2_1141	COG2233	PERMEase
FORC2_1142	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC2_1143	COG1393	Belongs to the ArsC family
FORC2_1144	COG4783	chaperone-mediated protein folding
FORC2_1145	COG0628	permease
FORC2_1146	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC2_1147	COG2716	regulation of RNA biosynthetic process
FORC2_1148	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC2_1149	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC2_1150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC2_1151	COG2321	neutral zinc metallopeptidase
FORC2_1152	COG2707	UPF0756 membrane protein
FORC2_1153	COG1444	tRNA N-acetyltransferase activity
FORC2_1154	COG0400	carboxylic ester hydrolase activity
FORC2_1156	COG1876	peptidase activity
FORC2_1157	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC2_1158	COG1393	Belongs to the ArsC family
FORC2_1192	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC2_1194	COG2197	response regulator
FORC2_1196	COG3062	negative regulation of establishment of protein localization
FORC2_1197	COG0243	molybdopterin cofactor binding
FORC2_1198	COG3043	anaerobic respiration
FORC2_1199	COG3005	denitrification pathway
FORC2_1200	COG0494	nUDIX hydrolase
FORC2_1204	COG1671	Belongs to the UPF0178 family
FORC2_1205	COG0408	coproporphyrinogen oxidase activity
FORC2_1206	COG0456	acetyltransferase
FORC2_1208	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC2_1210	COG2837	iron assimilation
FORC2_1211	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC2_1214	COG2731	YhcH YjgK YiaL family protein
FORC2_1215	COG1737	Transcriptional regulator
FORC2_1217	COG4150	thiosulfate binding
FORC2_1218	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FORC2_1219	COG4208	sulfate ABC transporter
FORC2_1223	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_1224	COG0745	RESPONSE REGULATOR receiver
FORC2_1225	COG2205	protein histidine kinase activity
FORC2_1226	COG2190	(PTS) system
FORC2_1227	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC2_1228	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_1229	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC2_1232	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC2_1233	COG3530	Putative quorum-sensing-regulated virulence factor
FORC2_1237	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC2_1238	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC2_1239	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC2_1241	COG0667	Aldo Keto reductase
FORC2_1242	COG3961	Belongs to the TPP enzyme family
FORC2_1245	COG0837	glucose binding
FORC2_1246	COG2223	nitrite transmembrane transporter activity
FORC2_1247	COG3279	Response regulator of the LytR AlgR family
FORC2_1248	COG3275	phosphorelay sensor kinase activity
FORC2_1251	COG0436	Aminotransferase
FORC2_1252	COG3038	cytochrome b561
FORC2_1253	COG1598	PFAM Uncharacterised protein family UPF0150
FORC2_1256	COG2723	6-phospho-beta-galactosidase activity
FORC2_1258	COG1280	lysine exporter protein (LysE YggA)
FORC2_1262	COG2951	lytic endotransglycosylase activity
FORC2_1263	COG0531	amino acid
FORC2_1267	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC2_1268	COG1127	ABC transporter
FORC2_1272	COG2755	lipolytic protein G-D-S-L family
FORC2_1272	COG0657	acetylesterase activity
FORC2_1273	COG3038	cytochrome b561
FORC2_1274	COG2353	YceI-like domain
FORC2_1275	COG1609	Transcriptional regulator
FORC2_1276	COG1263	PTS System
FORC2_1276	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_1277	COG2723	6-phospho-beta-galactosidase activity
FORC2_1279	COG1695	Transcriptional regulator
FORC2_1280	COG2824	Alkylphosphonate utilization operon protein PhnA
FORC2_1284	COG3210	domain, Protein
FORC2_1294	COG2831	hemolysin activation secretion protein
FORC2_1296	COG3121	Chaperone
FORC2_1298	COG3121	Chaperone
FORC2_1300	COG3188	usher protein
FORC2_1304	COG4977	sequence-specific DNA binding
FORC2_1311	COG2116	formate transmembrane transporter activity
FORC2_1313	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC2_1314	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC2_1315	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC2_1316	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC2_1317	COG1138	Cytochrome C-type biogenesis protein
FORC2_1318	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC2_1320	COG3088	subunit of a heme lyase
FORC2_1320	COG4235	cytochrome complex assembly
FORC2_1325	COG3691	Protein conserved in bacteria
FORC2_1326	COG0183	Belongs to the thiolase family
FORC2_1327	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC2_1327	COG1024	Enoyl-CoA hydratase
FORC2_1328	COG2062	phosphohistidine phosphatase, SixA
FORC2_1329	COG2840	Smr protein MutS2
FORC2_1330	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC2_1331	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC2_1332	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FORC2_1333	COG0730	response to heat
FORC2_1334	COG3101	peptidyl-lysine hydroxylation
FORC2_1336	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC2_1336	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC2_1337	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC2_1338	COG3706	GGDEF domain
FORC2_1339	COG1794	racemase activity, acting on amino acids and derivatives
FORC2_1341	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC2_1342	COG2723	6-phospho-beta-galactosidase activity
FORC2_1343	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC2_1345	COG1609	Transcriptional regulator
FORC2_1347	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FORC2_1352	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC2_1353	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC2_1354	COG0697	spore germination
FORC2_1355	COG0697	spore germination
FORC2_1357	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC2_1358	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC2_1360	COG0586	Pfam SNARE associated Golgi protein
FORC2_1361	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC2_1362	COG0285	dihydrofolate synthase activity
FORC2_1363	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC2_1364	COG1286	toxin biosynthetic process
FORC2_1365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC2_1366	COG0163	prenyltransferase activity
FORC2_1367	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_1368	COG4215	(ABC) transporter
FORC2_1369	COG4160	amino acid transport
FORC2_1370	COG4598	ABC transporter
FORC2_1371	COG1090	epimerase
FORC2_1373	COG0622	Phosphoesterase
FORC2_1374	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FORC2_1375	COG3037	sugar-specific permease SgaT UlaA
FORC2_1377	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_1378	COG1609	Transcriptional regulator
FORC2_1379	COG0280	phosphate acetyltransferase
FORC2_1379	COG0857	belongs to the CobB CobQ family
FORC2_1381	COG3092	negative regulation of chromosome organization
FORC2_1382	COG3013	Belongs to the UPF0304 family
FORC2_1383	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC2_1385	COG0490	domain, Protein
FORC2_1385	COG0471	metal ion transport
FORC2_1386	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC2_1388	COG0436	Aminotransferase
FORC2_1389	COG0583	DNA-binding transcription factor activity
FORC2_1390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_1391	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_1392	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_1392	COG0649	NAD binding
FORC2_1393	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FORC2_1395	COG1034	ATP synthesis coupled electron transport
FORC2_1396	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FORC2_1397	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_1398	COG0839	Belongs to the complex I subunit 6 family
FORC2_1399	COG0713	ATP synthesis coupled electron transport
FORC2_1400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FORC2_1401	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_1402	COG1007	ATP synthesis coupled electron transport
FORC2_1408	COG3265	gluconokinase activity
FORC2_1409	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_1410	COG1609	Transcriptional regulator
FORC2_1411	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC2_1413	COG4702	Belongs to the UPF0303 family
FORC2_1414	COG0129	dihydroxy-acid dehydratase activity
FORC2_1415	COG4575	ribosome binding
FORC2_1416	COG1169	isochorismate synthase
FORC2_1417	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC2_1418	COG0596	Alpha beta hydrolase
FORC2_1419	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC2_1420	COG1441	menaquinone biosynthetic process
FORC2_1424	COG0814	amino acid
FORC2_1428	COG4574	serine-type endopeptidase inhibitor activity
FORC2_1429	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC2_1431	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC2_1432	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC2_1434	COG2205	protein histidine kinase activity
FORC2_1434	COG0784	Response regulator, receiver
FORC2_1436	COG0642	Histidine kinase
FORC2_1436	COG2198	Histidine kinase
FORC2_1437	COG2223	nitrite transmembrane transporter activity
FORC2_1440	COG1132	(ABC) transporter
FORC2_1442	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC2_1443	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FORC2_1452	COG1737	Transcriptional regulator
FORC2_1453	COG1263	PTS System
FORC2_1453	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_1453	COG2190	(PTS) system
FORC2_1454	COG2723	6-phospho-beta-galactosidase activity
FORC2_1458	COG3082	Protein of unknown function (DUF1414)
FORC2_1459	COG3081	Nucleoid-associated protein
FORC2_1461	COG1061	Type III restriction enzyme res subunit
FORC2_1462	COG1187	pseudouridine synthase activity
FORC2_1463	COG2814	Major facilitator Superfamily
FORC2_1465	COG4172	Belongs to the ABC transporter superfamily
FORC2_1466	COG4239	(ABC) transporter, permease
FORC2_1467	COG4174	ABC transporter (Permease)
FORC2_1468	COG4166	transmembrane transport
FORC2_1469	COG2200	EAL domain
FORC2_1470	COG0791	NLP P60 protein
FORC2_1471	COG0671	phosphoesterase, PA-phosphatase related
FORC2_1472	COG0523	cobalamin synthesis protein
FORC2_1474	COG2186	Transcriptional regulator
FORC2_1475	COG0246	Mannitol dehydrogenase
FORC2_1477	COG1312	Catalyzes the dehydration of D-mannonate
FORC2_1478	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC2_1481	COG0243	molybdopterin cofactor binding
FORC2_1482	COG3005	denitrification pathway
FORC2_1485	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC2_1486	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC2_1486	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC2_1486	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC2_1487	COG3710	Transcriptional regulator
FORC2_1492	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC2_1493	COG2855	membrane
FORC2_1495	COG0583	DNA-binding transcription factor activity
FORC2_1496	COG0833	amino acid
FORC2_1497	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC2_1499	COG4771	TonB-dependent receptor
FORC2_1500	COG0625	glutathione transferase activity
FORC2_1505	COG2011	ABC-type metal ion transport system permease component
FORC2_1508	COG0626	cystathionine gamma-synthase activity
FORC2_1510	COG1686	Belongs to the peptidase S11 family
FORC2_1511	COG1760	l-serine dehydratase
FORC2_1512	COG0814	amino acid
FORC2_1513	COG1349	DNA-binding transcription factor activity
FORC2_1514	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC2_1515	COG0671	phosphoesterase, PA-phosphatase related
FORC2_1517	COG2985	domain, Protein
FORC2_1517	COG0569	domain protein
FORC2_1518	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC2_1521	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC2_1522	COG3842	ATPase activity
FORC2_1523	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC2_1524	COG1177	transmembrane transport
FORC2_1526	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC2_1527	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_1529	COG4160	amino acid transport
FORC2_1530	COG4215	(ABC) transporter
FORC2_1531	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_1532	COG1126	abc transporter atp-binding protein
FORC2_1534	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC2_1535	COG0702	epimerase
FORC2_1536	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC2_1537	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC2_1538	COG0028	Belongs to the TPP enzyme family
FORC2_1539	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC2_1540	COG1151	hydroxylamine reductase activity
FORC2_1541	COG2431	L-lysine efflux transmembrane transporter activity
FORC2_1542	COG3593	DNA synthesis involved in DNA repair
FORC2_1543	COG2990	Protein conserved in bacteria
FORC2_1544	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_1546	COG1278	Cold shock
FORC2_1547	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC2_1548	COG0542	response to heat
FORC2_1549	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC2_1550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC2_1551	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC2_1553	COG0492	ferredoxin-NADP+ reductase activity
FORC2_1554	COG1522	sequence-specific DNA binding
FORC2_1555	COG3107	peptidoglycan biosynthetic process
FORC2_1555	COG1674	ftsk spoiiie
FORC2_1556	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC2_1557	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC2_1558	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC2_1559	COG2814	Major facilitator Superfamily
FORC2_1560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC2_1561	COG1882	Formate acetyltransferase
FORC2_1562	COG2116	formate transmembrane transporter activity
FORC2_1563	COG1944	ATP diphosphatase activity
FORC2_1564	COG0252	asparaginase activity
FORC2_1565	COG2323	membrane
FORC2_1566	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC2_1567	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC2_1568	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC2_1569	COG0539	negative regulation of cytoplasmic translation
FORC2_1570	COG0776	regulation of translation
FORC2_1571	COG0658	competence protein
FORC2_1571	COG2333	competence protein COMEC
FORC2_1573	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC2_1574	COG5383	Protein conserved in bacteria
FORC2_1575	COG1278	Cold shock
FORC2_1576	COG1278	Cold shock
FORC2_1577	COG2835	tetraacyldisaccharide 4'-kinase activity
FORC2_1578	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC2_1579	COG3173	Aminoglycoside phosphotransferase
FORC2_1580	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC2_1581	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC2_1582	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC2_1583	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC2_1584	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC2_1585	COG2989	Protein conserved in bacteria
FORC2_1586	COG3108	Peptidase M15
FORC2_1587	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC2_1588	COG2200	EAL domain
FORC2_1589	COG1448	Aminotransferase
FORC2_1591	COG0017	Asparaginyl-tRNA synthetase
FORC2_1592	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC2_1593	COG0308	aminopeptidase N
FORC2_1594	COG0167	dihydroorotate dehydrogenase activity
FORC2_1596	COG3217	Mosc domain protein beta barrel domain protein
FORC2_1596	COG0633	Ferredoxin
FORC2_1597	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC2_1597	COG0116	Belongs to the methyltransferase superfamily
FORC2_1598	COG0488	(ABC) transporter
FORC2_1599	COG2995	paraquat-inducible protein a
FORC2_1600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC2_1600	COG3008	intermembrane lipid transfer
FORC2_1601	COG3009	Protein conserved in bacteria
FORC2_1602	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC2_1604	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC2_1605	COG1067	ATP-dependent peptidase activity
FORC2_1606	COG3120	sequence-specific DNA binding
FORC2_1607	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FORC2_1607	COG2885	chlorophyll binding
FORC2_1608	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
FORC2_1609	COG3070	regulator of competence-specific genes
FORC2_1610	COG1289	transmembrane transporter activity
FORC2_1611	COG3304	Inner membrane component domain
FORC2_1612	COG0210	DNA helicase
FORC2_1613	COG1803	Methylglyoxal synthase
FORC2_1614	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC2_1615	COG1832	CoA-binding protein
FORC2_1616	COG3785	DNA binding
FORC2_1617	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC2_1620	COG1254	Belongs to the acylphosphatase family
FORC2_1621	COG2920	part of a sulfur-relay system
FORC2_1624	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC2_1625	COG0437	4 iron, 4 sulfur cluster binding
FORC2_1626	COG3301	Polysulphide reductase, NrfD
FORC2_1627	COG1138	Cytochrome C-type biogenesis protein
FORC2_1629	COG3088	subunit of a heme lyase
FORC2_1630	COG4235	cytochrome complex assembly
FORC2_1631	COG2771	luxR family
FORC2_1632	COG3916	Acyl-homoserine-lactone synthase
FORC2_1634	COG3263	regulation of cellular component size
FORC2_1637	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
FORC2_1638	COG2943	transferase activity, transferring hexosyl groups
FORC2_1639	COG5645	(Lipo)protein
FORC2_1641	COG3104	oligopeptide transport
FORC2_1642	COG2814	Major facilitator Superfamily
FORC2_1643	COG2259	Doxx family
FORC2_1644	COG1560	Kdo2-lipid A biosynthetic process
FORC2_1652	COG0628	permease
FORC2_1657	COG0418	dihydroorotase activity
FORC2_1658	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC2_1659	COG1530	ribonuclease E activity
FORC2_1659	COG1530	ribonuclease E activity
FORC2_1660	COG0564	pseudouridine synthase activity
FORC2_1662	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC2_1663	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FORC2_1664	COG0416	fatty acid biosynthetic process
FORC2_1665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC2_1666	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORC2_1667	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_1669	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC2_1670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC2_1671	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC2_1672	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC2_1673	COG0470	DNA polymerase III
FORC2_1674	COG0084	hydrolase, TatD family'
FORC2_1675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_1675	COG1263	PTS System
FORC2_1677	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC2_1678	COG0537	adenosine 5'-monophosphoramidase activity
FORC2_1679	COG5633	Lipoprotein
FORC2_1680	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
FORC2_1681	COG0510	thiamine kinase activity
FORC2_1682	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC2_1683	COG3150	esterase
FORC2_1684	COG1252	NADH dehydrogenase
FORC2_1685	COG3134	Outer membrane lipoprotein
FORC2_1686	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC2_1687	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC2_1689	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC2_1690	COG1940	carbohydrate kinase activity
FORC2_1691	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC2_1693	COG2850	peptidyl-arginine hydroxylation
FORC2_1695	COG0745	RESPONSE REGULATOR receiver
FORC2_1697	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC2_1698	COG2915	High frequency lysogenization protein hflD homolog
FORC2_1699	COG0482	sulfurtransferase activity
FORC2_1701	COG1187	pseudouridine synthase activity
FORC2_1702	COG0538	isocitrate dehydrogenase activity
FORC2_1713	COG3772	lysozyme
FORC2_1717	COG2873	o-acetylhomoserine
FORC2_1718	COG0702	epimerase
FORC2_1719	COG1733	regulation of RNA biosynthetic process
FORC2_1723	COG0765	amino acid transport
FORC2_1724	COG0765	amino acid transport
FORC2_1725	COG1126	abc transporter atp-binding protein
FORC2_1726	COG2721	sulfolactate sulfo-lyase activity
FORC2_1727	COG0246	Mannitol dehydrogenase
FORC2_1728	COG1063	alcohol dehydrogenase
FORC2_1729	COG1802	Transcriptional regulator
FORC2_1730	COG4948	Mandelate Racemase Muconate Lactonizing
FORC2_1732	COG2271	Major facilitator Superfamily
FORC2_1733	COG0697	spore germination
FORC2_1735	COG3755	Protein conserved in bacteria
FORC2_1738	COG5001	Diguanylate cyclase
FORC2_1738	COG3706	GGDEF domain
FORC2_1738	COG2203	Gaf domain
FORC2_1738	COG4251	negative regulation of phosphorylation
FORC2_1742	COG1132	(ABC) transporter
FORC2_1747	COG2207	Transcriptional regulator
FORC2_1754	COG1113	amino acid transport
FORC2_1757	COG1278	Cold shock
FORC2_1759	COG0768	penicillin binding
FORC2_1760	COG2226	methyltransferase
FORC2_1762	COG5002	protein histidine kinase activity
FORC2_1762	COG3447	MASE1 domain protein
FORC2_1762	COG5001	Diguanylate cyclase
FORC2_1764	COG1971	Probably functions as a manganese efflux pump
FORC2_1765	COG4811	Protein of unknown function (DUF986)
FORC2_1766	COG3716	PTS system mannose fructose sorbose family IID component
FORC2_1767	COG3715	PTS system
FORC2_1768	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_1768	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_1769	COG1253	flavin adenine dinucleotide binding
FORC2_1770	COG1760	l-serine dehydratase
FORC2_1771	COG0494	nUDIX hydrolase
FORC2_1773	COG3140	Belongs to the UPF0181 family
FORC2_1774	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC2_1775	COG0513	Belongs to the DEAD box helicase family
FORC2_1776	COG3141	response to X-ray
FORC2_1779	COG1770	oligopeptidase
FORC2_1780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC2_1783	COG1528	Iron-storage protein
FORC2_1784	COG2372	response to copper ion
FORC2_1785	COG1276	copper resistance
FORC2_1801	COG2826	transposase and inactivated derivatives, IS30 family
FORC2_1810	COG0488	(ABC) transporter
FORC2_1817	COG3772	lysozyme
FORC2_1818	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC2_1819	COG2979	Protein of unknown function (DUF533)
FORC2_1822	COG2186	Transcriptional regulator
FORC2_1823	COG3734	2-keto-3-deoxy-galactonokinase
FORC2_1824	COG0800	Aldolase
FORC2_1825	COG4948	Mandelate Racemase Muconate Lactonizing
FORC2_1827	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC2_1828	COG0012	GTP binding
FORC2_1830	COG0193	aminoacyl-tRNA hydrolase activity
FORC2_1832	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC2_1834	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC2_1835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC2_1836	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC2_1837	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC2_1838	COG3094	Invasion gene expression up-regulator, SirB
FORC2_1839	COG2912	Transglutaminase-like superfamily
FORC2_1840	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC2_1841	COG0659	secondary active sulfate transmembrane transporter activity
FORC2_1842	COG3706	GGDEF domain
FORC2_1844	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC2_1845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC2_1846	COG3381	protein complex oligomerization
FORC2_1848	COG0477	Major facilitator Superfamily
FORC2_1853	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC2_1855	COG0673	inositol 2-dehydrogenase activity
FORC2_1856	COG0728	peptidoglycan biosynthetic process
FORC2_1857	COG0018	arginyl-trna synthetase
FORC2_1858	COG3102	Protein conserved in bacteria
FORC2_1859	COG3142	Participates in the control of copper homeostasis
FORC2_1860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC2_1861	COG2226	methyltransferase
FORC2_1862	COG3788	relative of glutathione S-transferase, MAPEG superfamily
FORC2_1863	COG1801	Protein of unknown function DUF72
FORC2_1864	COG1335	isochorismatase
FORC2_1865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC2_1866	COG0494	nUDIX hydrolase
FORC2_1867	COG0217	transcriptional regulatory protein
FORC2_1868	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC2_1869	COG0632	four-way junction helicase activity
FORC2_1870	COG2255	four-way junction helicase activity
FORC2_1871	COG3104	oligopeptide transport
FORC2_1872	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC2_1873	COG1121	(ABC) transporter
FORC2_1874	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC2_1875	COG0739	heme binding
FORC2_1876	COG1560	Kdo2-lipid A biosynthetic process
FORC2_1877	COG0469	pyruvate kinase activity
FORC2_1878	COG1737	Transcriptional regulator
FORC2_1879	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC2_1880	COG0800	Aldolase
FORC2_1881	COG2076	Multidrug Resistance protein
FORC2_1882	COG2076	Multidrug Resistance protein
FORC2_1883	COG0251	oxidation-reduction process
FORC2_1884	COG1199	ATP-dependent helicase activity
FORC2_1886	COG3065	identical protein binding
FORC2_1887	COG0318	PFAM AMP-dependent synthetase and ligase
FORC2_1888	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC2_1889	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC2_1890	COG2894	cell division
FORC2_1891	COG0850	regulation of cytokinetic process
FORC2_1893	COG3100	YcgL domain-containing protein
FORC2_1894	COG2951	lytic endotransglycosylase activity
FORC2_1895	COG0179	Fumarylacetoacetate (FAA) hydrolase
FORC2_1896	COG2983	Belongs to the UPF0260 family
FORC2_1898	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC2_1899	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC2_1900	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC2_1901	COG2186	Transcriptional regulator
FORC2_1902	COG2719	SpoVR family
FORC2_1903	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC2_1904	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC2_1905	COG2814	Major facilitator Superfamily
FORC2_1906	COG2199	diguanylate cyclase activity
FORC2_1906	COG2200	EAL domain
FORC2_1906	COG2202	Pas domain
FORC2_1908	COG0583	DNA-binding transcription factor activity
FORC2_1911	COG2718	Belongs to the UPF0229 family
FORC2_1912	COG2766	serine protein kinase
FORC2_1913	COG3713	MltA-interacting MipA family protein
FORC2_1916	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC2_1917	COG3139	Protein of unknown function (DUF1315)
FORC2_1918	COG1335	isochorismatase
FORC2_1919	COG0252	asparaginase activity
FORC2_1920	COG0616	signal peptide processing
FORC2_1921	COG0778	Nitroreductase
FORC2_1923	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC2_1925	COG0494	nUDIX hydrolase
FORC2_1926	COG0708	Exodeoxyribonuclease III
FORC2_1927	COG0583	DNA-binding transcription factor activity
FORC2_1928	COG0788	formyltetrahydrofolate deformylase activity
FORC2_1929	COG3012	SEC-C Motif Domain Protein
FORC2_1931	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC2_1932	COG0745	RESPONSE REGULATOR receiver
FORC2_1934	COG2916	Histone family protein nucleoid-structuring protein H-NS
FORC2_1936	COG1435	thymidine kinase activity
FORC2_1937	COG1012	belongs to the aldehyde dehydrogenase family
FORC2_1937	COG1454	alcohol dehydrogenase
FORC2_1938	COG2095	MarC family integral membrane protein
FORC2_1942	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC2_1943	COG0444	Belongs to the ABC transporter superfamily
FORC2_1945	COG3099	Belongs to the UPF0263 family
FORC2_1946	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC2_1949	COG2350	Protein conserved in bacteria
FORC2_1950	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC2_1951	COG1607	acyl-coa hydrolase
FORC2_1952	COG2917	probably involved in intracellular septation
FORC2_1956	COG3047	cAMP biosynthetic process
FORC2_1958	COG0159	tryptophan synthase activity
FORC2_1959	COG0133	tryptophan synthase activity
FORC2_1960	COG0135	phosphoribosylanthranilate isomerase activity
FORC2_1960	COG0134	indole-3-glycerol-phosphate synthase activity
FORC2_1962	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC2_1964	COG0613	PHP domain protein
FORC2_1965	COG0009	L-threonylcarbamoyladenylate synthase
FORC2_1966	COG1187	pseudouridine synthase activity
FORC2_1968	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC2_1969	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_1970	COG0616	signal peptide processing
FORC2_1972	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC2_1973	COG0583	DNA-binding transcription factor activity
FORC2_1984	COG4974	Belongs to the 'phage' integrase family
FORC2_1987	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FORC2_1988	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC2_1989	COG0671	phosphoesterase, PA-phosphatase related
FORC2_1990	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC2_1991	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC2_1993	COG1396	sequence-specific DNA binding
FORC2_1994	COG3135	benzoate transporter
FORC2_1996	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC2_1997	COG0023	Translation Initiation Factor
FORC2_1999	COG0235	Class ii aldolase
FORC2_2001	COG1349	DNA-binding transcription factor activity
FORC2_2002	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC2_2003	COG2879	small protein
FORC2_2004	COG1966	Carbon starvation protein
FORC2_2005	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC2_2006	COG0243	molybdopterin cofactor binding
FORC2_2009	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC2_2011	COG4659	FMN binding
FORC2_2012	COG4658	electron transport chain
FORC2_2013	COG2207	Transcriptional regulator
FORC2_2013	COG3708	Transcriptional regulator
FORC2_2014	COG4656	Part of a membrane complex involved in electron transport
FORC2_2016	COG4657	Part of a membrane complex involved in electron transport
FORC2_2018	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC2_2021	COG2160	L-arabinose isomerase activity
FORC2_2023	COG1879	ABC-type sugar transport system periplasmic component
FORC2_2025	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_2027	COG0673	inositol 2-dehydrogenase activity
FORC2_2028	COG0385	Bile acid
FORC2_2029	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC2_2030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FORC2_2031	COG1263	PTS System
FORC2_2031	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_2032	COG1609	Transcriptional regulator
FORC2_2034	COG5339	Protein conserved in bacteria
FORC2_2036	COG0114	fumarate hydratase activity
FORC2_2041	COG2814	Major facilitator Superfamily
FORC2_2042	COG0583	DNA-binding transcription factor activity
FORC2_2043	COG1940	carbohydrate kinase activity
FORC2_2044	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC2_2050	COG1742	UPF0060 membrane protein
FORC2_2051	COG4221	oxidoreductase activity
FORC2_2052	COG0477	Major facilitator Superfamily
FORC2_2059	COG0625	glutathione transferase activity
FORC2_2063	COG3604	Transcriptional regulator
FORC2_2064	COG0426	domain, Protein
FORC2_2064	COG1773	rubredoxin
FORC2_2065	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC2_2067	COG1522	sequence-specific DNA binding
FORC2_2069	COG4215	(ABC) transporter
FORC2_2072	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC2_2073	COG0583	DNA-binding transcription factor activity
FORC2_2074	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC2_2076	COG0483	inositol monophosphate 1-phosphatase activity
FORC2_2077	COG2271	Major facilitator Superfamily
FORC2_2081	COG0028	Belongs to the TPP enzyme family
FORC2_2082	COG0440	acetolactate synthase activity
FORC2_2083	COG1011	Hydrolase
FORC2_2087	COG0738	Major facilitator superfamily
FORC2_2088	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC2_2090	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_2092	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FORC2_2095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC2_2096	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC2_2097	COG0589	response to stress
FORC2_2098	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC2_2099	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC2_2102	COG0531	amino acid
FORC2_2104	COG0745	RESPONSE REGULATOR receiver
FORC2_2105	COG2205	protein histidine kinase activity
FORC2_2106	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC2_2108	COG3591	Belongs to the peptidase S1B family
FORC2_2111	COG1643	Atp-dependent helicase
FORC2_2112	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC2_2114	COG0246	Mannitol dehydrogenase
FORC2_2115	COG1070	Carbohydrate kinase
FORC2_2117	COG3784	Protein of unknown function (DUF1318)
FORC2_2119	COG2911	Protein conserved in bacteria
FORC2_2120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC2_2121	COG3042	response to heat
FORC2_2122	COG1285	pathogenesis
FORC2_2124	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FORC2_2124	COG1013	pyruvate-flavodoxin oxidoreductase activity
FORC2_2124	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_2124	COG0674	pyruvate-flavodoxin oxidoreductase activity
FORC2_2125	COG2723	6-phospho-beta-galactosidase activity
FORC2_2126	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_2126	COG2190	(PTS) system
FORC2_2126	COG1263	PTS System
FORC2_2127	COG3711	transcriptional antiterminator
FORC2_2128	COG0037	tRNA processing
FORC2_2129	COG0598	Magnesium transport protein CorA
FORC2_2132	COG4166	transmembrane transport
FORC2_2133	COG2866	Carboxypeptidase
FORC2_2134	COG4948	Mandelate Racemase Muconate Lactonizing
FORC2_2135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FORC2_2139	COG3768	UPF0283 membrane protein
FORC2_2140	COG3106	COG3106 Predicted ATPase
FORC2_2142	COG1983	PspC domain protein
FORC2_2144	COG1842	Phage shock protein A
FORC2_2145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC2_2148	COG4166	transmembrane transport
FORC2_2149	COG4168	peptide transport system, permease
FORC2_2150	COG4171	peptide transport system, permease
FORC2_2152	COG4172	Belongs to the ABC transporter superfamily
FORC2_2154	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC2_2154	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC2_2156	COG3104	oligopeptide transport
FORC2_2160	COG0625	glutathione transferase activity
FORC2_2162	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC2_2163	COG0259	pyridoxamine-phosphate oxidase activity
FORC2_2164	COG3895	Periplasmic Protein
FORC2_2165	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC2_2166	COG3133	Outer membrane lipoprotein
FORC2_2167	COG1846	Transcriptional regulator
FORC2_2169	COG1566	PFAM secretion protein HlyD family protein
FORC2_2170	COG1289	transmembrane transporter activity
FORC2_2171	COG4989	oxidoreductase activity
FORC2_2172	COG3313	Fe-S protein
FORC2_2173	COG2194	sulfuric ester hydrolase activity
FORC2_2174	COG1309	transcriptional regulator
FORC2_2175	COG1902	pentaerythritol trinitrate reductase activity
FORC2_2176	COG0346	lactoylglutathione lyase activity
FORC2_2177	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC2_2178	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC2_2179	COG0791	NLP P60 protein
FORC2_2180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FORC2_2181	COG1609	Transcriptional regulator
FORC2_2182	COG0583	DNA-binding transcription factor activity
FORC2_2183	COG2814	Major facilitator Superfamily
FORC2_2184	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC2_2185	COG0307	riboflavin synthase, alpha
FORC2_2186	COG0534	Mate efflux family protein
FORC2_2188	COG4238	major outer membrane lipoprotein
FORC2_2189	COG1376	ErfK ybiS ycfS ynhG family protein
FORC2_2189	COG1388	LysM domain
FORC2_2190	COG2166	iron-sulfur cluster assembly
FORC2_2192	COG0719	Fe-S assembly protein
FORC2_2193	COG0396	ATPase activity
FORC2_2194	COG0719	Fe-S assembly protein
FORC2_2195	COG0316	Belongs to the HesB IscA family
FORC2_2196	COG2050	protein possibly involved in aromatic compounds catabolism
FORC2_2197	COG0277	FAD linked oxidase domain protein
FORC2_2197	COG0247	lactate metabolic process
FORC2_2198	COG0628	permease
FORC2_2199	COG0574	Belongs to the PEP-utilizing enzyme family
FORC2_2199	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC2_2200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC2_2203	COG4771	TonB-dependent receptor
FORC2_2204	COG3720	iron ion transport
FORC2_2205	COG4558	Periplasmic binding protein
FORC2_2207	COG0095	Lipoate-protein ligase
FORC2_2208	COG0791	NLP P60 protein
FORC2_2209	COG2076	Multidrug Resistance protein
FORC2_2210	COG2076	Multidrug Resistance protein
FORC2_2211	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC2_2212	COG0726	polysaccharide deacetylase
FORC2_2213	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC2_2213	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC2_2214	COG0463	Glycosyl transferase, family 2
FORC2_2215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC2_2216	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC2_2217	COG0386	Belongs to the glutathione peroxidase family
FORC2_2218	COG4139	cobalamin transport
FORC2_2220	COG0776	regulation of translation
FORC2_2222	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC2_2223	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FORC2_2224	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC2_2225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FORC2_2226	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC2_2227	COG4249	Peptidase C14 caspase catalytic subunit p20
FORC2_2228	COG1811	Na channel or pump
FORC2_2235	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC2_2236	COG1121	(ABC) transporter
FORC2_2237	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC2_2238	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC2_2240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC2_2240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FORC2_2241	COG1703	isobutyryl-CoA mutase activity
FORC2_2242	COG1024	Enoyl-CoA hydratase
FORC2_2243	COG0427	acetyl-CoA hydrolase
FORC2_2244	COG0583	DNA-binding transcription factor activity
FORC2_2246	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC2_2247	COG1917	Cupin 2, conserved barrel domain protein
FORC2_2248	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FORC2_2249	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_2252	COG1175	transmembrane transport
FORC2_2253	COG0395	ABC-type sugar transport system, permease component
FORC2_2254	COG3842	ATPase activity
FORC2_2255	COG1653	transport
FORC2_2256	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC2_2258	COG1988	membrane-bound metal-dependent
FORC2_2260	COG3023	N-Acetylmuramoyl-L-alanine amidase
FORC2_2262	COG0823	Involved in the tonB-independent uptake of proteins
FORC2_2263	COG2814	Major facilitator Superfamily
FORC2_2268	COG0501	Belongs to the peptidase M48B family
FORC2_2269	COG0793	Belongs to the peptidase S41A family
FORC2_2271	COG1956	GAF domain-containing protein
FORC2_2272	COG2995	paraquat-inducible protein a
FORC2_2273	COG3008	intermembrane lipid transfer
FORC2_2275	COG2814	Major facilitator Superfamily
FORC2_2282	COG5001	Diguanylate cyclase
FORC2_2282	COG2203	Gaf domain
FORC2_2282	COG4251	negative regulation of phosphorylation
FORC2_2282	COG3706	GGDEF domain
FORC2_2287	COG0625	glutathione transferase activity
FORC2_2288	COG0668	transmembrane transport
FORC2_2292	COG0786	glutamate:sodium symporter activity
FORC2_2293	COG1187	pseudouridine synthase activity
FORC2_2296	COG1349	DNA-binding transcription factor activity
FORC2_2298	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_2300	COG3716	PTS system mannose fructose sorbose family IID component
FORC2_2301	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_2302	COG2222	sugar isomerase
FORC2_2304	COG4942	peptidase
FORC2_2306	COG3443	Belongs to the bacterial solute-binding protein 9 family
FORC2_2308	COG0402	S-adenosylhomocysteine deaminase activity
FORC2_2310	COG1228	amidohydrolase
FORC2_2313	COG2988	succinylglutamate desuccinylase activity
FORC2_2314	COG3724	N-succinylarginine dihydrolase activity
FORC2_2316	COG3138	arginine N-succinyltransferase
FORC2_2317	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC2_2318	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC2_2319	COG1271	oxidase subunit
FORC2_2320	COG1294	oxidase, subunit
FORC2_2321	COG3850	Histidine kinase
FORC2_2322	COG0583	DNA-binding transcription factor activity
FORC2_2323	COG2814	Major facilitator Superfamily
FORC2_2325	COG0387	Pfam Sodium calcium exchanger
FORC2_2326	COG1702	phosphate starvation-inducible protein PhoH
FORC2_2329	COG3658	cytochrome
FORC2_2330	COG1215	transferase activity, transferring glycosyl groups
FORC2_2331	COG1649	PFAM Uncharacterised BCR, COG1649
FORC2_2331	COG0726	polysaccharide deacetylase
FORC2_2332	COG0457	Tetratricopeptide repeat
FORC2_2333	COG0006	proline dipeptidase activity
FORC2_2334	COG4114	ferric iron reductase
FORC2_2335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC2_2340	COG1136	(ABC) transporter
FORC2_2340	COG0577	efflux transmembrane transporter activity
FORC2_2342	COG1136	(ABC) transporter
FORC2_2342	COG0577	efflux transmembrane transporter activity
FORC2_2345	COG0672	)-iron permease
FORC2_2348	COG2066	Belongs to the glutaminase family
FORC2_2349	COG3622	Belongs to the hyi family
FORC2_2350	COG0235	Class ii aldolase
FORC2_2351	COG3395	kinase activity
FORC2_2352	COG1349	DNA-binding transcription factor activity
FORC2_2353	COG3290	protein histidine kinase activity
FORC2_2354	COG4565	transcriptional regulatory protein
FORC2_2355	COG3493	citrate carrier protein
FORC2_2359	COG0346	lactoylglutathione lyase activity
FORC2_2361	COG2223	nitrite transmembrane transporter activity
FORC2_2362	COG0561	phosphatase activity
FORC2_2365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FORC2_2382	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC2_2400	COG3772	lysozyme
FORC2_2411	COG0305	Participates in initiation and elongation during chromosome replication
FORC2_2427	COG4974	Belongs to the 'phage' integrase family
FORC2_2441	COG4695	Portal protein
FORC2_2468	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC2_2469	COG0322	excinuclease ABC activity
FORC2_2470	COG2197	response regulator
FORC2_2472	COG3136	membrane protein required for alginate biosynthesis
FORC2_2474	COG0366	Alpha amylase catalytic
FORC2_2477	COG2226	methyltransferase
FORC2_2480	COG1113	amino acid transport
FORC2_2481	COG1309	transcriptional regulator
FORC2_2482	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC2_2483	COG1335	isochorismatase
FORC2_2484	COG0251	oxidation-reduction process
FORC2_2485	COG2267	carboxylic ester hydrolase activity
FORC2_2486	COG0778	Nitroreductase
FORC2_2487	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FORC2_2488	COG2233	PERMEase
FORC2_2489	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FORC2_2491	COG0655	NAD(P)H dehydrogenase (quinone) activity
FORC2_2496	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FORC2_2496	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FORC2_2496	COG0506	proline dehydrogenase activity
FORC2_2502	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FORC2_2504	COG1191	sigma factor activity
FORC2_2514	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC2_2515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC2_2516	COG1677	Flagellar hook-basal body complex protein FliE
FORC2_2518	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC2_2519	COG1317	bacterial-type flagellum organization
FORC2_2521	COG2882	bacterial-type flagellum organization
FORC2_2523	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC2_2527	COG1338	Plays a role in the flagellum-specific transport system
FORC2_2531	COG1256	bacterial-type flagellum assembly
FORC2_2535	COG4786	Flagellar basal body rod
FORC2_2537	COG1749	Flagellar hook protein flgE
FORC2_2538	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC2_2539	COG1558	bacterial-type flagellum-dependent cell motility
FORC2_2540	COG1815	bacterial-type flagellum-dependent cell motility
FORC2_2542	COG2747	anti-sigma28 factor FlgM
FORC2_2543	COG3418	PFAM FlgN family protein
FORC2_2546	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC2_2547	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC2_2548	COG4935	Belongs to the peptidase S8 family
FORC2_2548	COG1404	Belongs to the peptidase S8 family
FORC2_2549	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC2_2550	COG0745	RESPONSE REGULATOR receiver
FORC2_2552	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC2_2553	COG0840	transmembrane signaling receptor activity
FORC2_2554	COG0840	transmembrane signaling receptor activity
FORC2_2555	COG0835	chemotaxis
FORC2_2556	COG2198	Histidine kinase
FORC2_2556	COG0643	Histidine kinase
FORC2_2557	COG1360	Flagellar Motor Protein
FORC2_2561	COG0589	response to stress
FORC2_2562	COG2130	NADP-dependent
FORC2_2564	COG1285	pathogenesis
FORC2_2565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FORC2_2566	COG0840	transmembrane signaling receptor activity
FORC2_2568	COG1278	Cold shock
FORC2_2569	COG1609	Transcriptional regulator
FORC2_2570	COG3250	beta-galactosidase activity
FORC2_2571	COG0604	alcohol dehydrogenase
FORC2_2571	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_2571	COG3321	synthase
FORC2_2577	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC2_2578	COG3121	Chaperone
FORC2_2583	COG1070	Carbohydrate kinase
FORC2_2584	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC2_2586	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_2587	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_2588	COG1129	ABC transporter
FORC2_2590	COG3228	Belongs to the MtfA family
FORC2_2592	COG3122	Protein conserved in bacteria
FORC2_2593	COG1136	(ABC) transporter
FORC2_2593	COG0577	efflux transmembrane transporter activity
FORC2_2594	COG0577	efflux transmembrane transporter activity
FORC2_2594	COG1136	(ABC) transporter
FORC2_2599	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_2599	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_2600	COG2814	Major facilitator Superfamily
FORC2_2603	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC2_2606	COG0471	metal ion transport
FORC2_2609	COG3051	citrate lyase alpha subunit
FORC2_2610	COG2301	Belongs to the HpcH HpaI aldolase family
FORC2_2611	COG3052	prosthetic group binding
FORC2_2612	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FORC2_2613	COG3290	protein histidine kinase activity
FORC2_2614	COG4565	transcriptional regulatory protein
FORC2_2617	COG2271	Major facilitator Superfamily
FORC2_2618	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC2_2620	COG3842	ATPase activity
FORC2_2631	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_2631	COG2205	protein histidine kinase activity
FORC2_2636	COG3121	Chaperone
FORC2_2640	COG1063	alcohol dehydrogenase
FORC2_2642	COG4214	carbohydrate transport
FORC2_2646	COG1129	ABC transporter
FORC2_2648	COG4221	oxidoreductase activity
FORC2_2650	COG0835	chemotaxis
FORC2_2650	COG0784	Response regulator, receiver
FORC2_2652	COG1349	DNA-binding transcription factor activity
FORC2_2653	COG0561	phosphatase activity
FORC2_2654	COG0352	thiamine-phosphate diphosphorylase activity
FORC2_2656	COG0534	Mate efflux family protein
FORC2_2657	COG0137	argininosuccinate synthase activity
FORC2_2670	COG3121	Chaperone
FORC2_2682	COG2211	Major facilitator Superfamily
FORC2_2683	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC2_2685	COG0583	DNA-binding transcription factor activity
FORC2_2686	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC2_2690	COG1492	cobalamin metabolic process
FORC2_2700	COG2875	Belongs to the precorrin methyltransferase family
FORC2_2702	COG2241	protein methyltransferase activity
FORC2_2703	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FORC2_2705	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FORC2_2709	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FORC2_2716	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FORC2_2721	COG2096	Adenosyltransferase
FORC2_2724	COG4656	Part of a membrane complex involved in electron transport
FORC2_2726	COG4810	utilization protein
FORC2_2728	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC2_2729	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC2_2729	COG1648	precorrin-2 dehydrogenase activity
FORC2_2730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC2_2733	COG1879	ABC-type sugar transport system periplasmic component
FORC2_2735	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_2737	COG2926	Belongs to the UPF0265 family
FORC2_2738	COG1289	transmembrane transporter activity
FORC2_2739	COG3320	Male sterility
FORC2_2739	COG1022	Amp-dependent synthetase and ligase
FORC2_2740	COG2925	Exonuclease
FORC2_2741	COG0531	amino acid
FORC2_2743	COG0371	Dehydrogenase
FORC2_2745	COG1129	ABC transporter
FORC2_2746	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_2747	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC2_2748	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC2_2750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC2_2751	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC2_2751	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC2_2752	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC2_2753	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC2_2754	COG0107	imidazoleglycerol-phosphate synthase activity
FORC2_2755	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC2_2755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC2_2756	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC2_2757	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FORC2_2758	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FORC2_2759	COG1253	flavin adenine dinucleotide binding
FORC2_2760	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC2_2761	COG2982	Protein involved in outer membrane biogenesis
FORC2_2763	COG0572	uridine kinase
FORC2_2764	COG0489	protein tyrosine kinase activity
FORC2_2765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC2_2765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC2_2769	COG2814	Major facilitator Superfamily
FORC2_2770	COG1380	Effector of murein hydrolase LrgA
FORC2_2771	COG1346	cytolysis
FORC2_2774	COG0281	malic enzyme
FORC2_2775	COG2949	membrane
FORC2_2776	COG0298	carbon dioxide binding
FORC2_2777	COG0375	protein maturation
FORC2_2778	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC2_2779	COG0651	ATP synthesis coupled electron transport
FORC2_2780	COG0650	Formate hydrogenlyase subunit 4
FORC2_2781	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FORC2_2782	COG4237	Hydrogenase 4 membrane
FORC2_2783	COG0651	ATP synthesis coupled electron transport
FORC2_2784	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FORC2_2784	COG3261	NADH dehydrogenase
FORC2_2785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC2_2786	COG3260	NADH ubiquinone oxidoreductase 20
FORC2_2788	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FORC2_2789	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC2_2790	COG3383	formate dehydrogenase (NAD+) activity
FORC2_2791	COG3604	Transcriptional regulator
FORC2_2792	COG2116	formate transmembrane transporter activity
FORC2_2797	COG2311	Membrane
FORC2_2798	COG0302	gtp cyclohydrolase
FORC2_2799	COG0477	Major facilitator Superfamily
FORC2_2800	COG0583	DNA-binding transcription factor activity
FORC2_2806	COG1136	(ABC) transporter
FORC2_2806	COG0577	efflux transmembrane transporter activity
FORC2_2809	COG0303	'Molybdopterin
FORC2_2810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC2_2811	COG0488	(ABC) transporter
FORC2_2815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FORC2_2819	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FORC2_2822	COG4106	trans-aconitate 2-methyltransferase activity
FORC2_2823	COG0783	Belongs to the Dps family
FORC2_2824	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC2_2825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_2826	COG0765	amino acid transport
FORC2_2827	COG1126	abc transporter atp-binding protein
FORC2_2829	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC2_2833	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC2_2834	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC2_2838	COG0697	spore germination
FORC2_2840	COG0583	DNA-binding transcription factor activity
FORC2_2843	COG1174	glycine betaine transport
FORC2_2844	COG1125	glycine betaine transport
FORC2_2845	COG1174	glycine betaine transport
FORC2_2846	COG1732	Glycine betaine
FORC2_2849	COG2897	thiosulfate sulfurtransferase activity
FORC2_2851	COG0411	ABC transporter
FORC2_2855	COG4807	Protein conserved in bacteria
FORC2_2858	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FORC2_2860	COG2261	transglycosylase associated protein
FORC2_2862	COG1403	HNH endonuclease
FORC2_2864	COG0277	FAD linked oxidase domain protein
FORC2_2865	COG1686	Belongs to the peptidase S11 family
FORC2_2868	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC2_2869	COG0513	Belongs to the DEAD box helicase family
FORC2_2870	COG1309	transcriptional regulator
FORC2_2871	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_2872	COG1131	(ABC) transporter
FORC2_2873	COG0842	Transport permease protein
FORC2_2874	COG0842	Transport permease protein
FORC2_2875	COG0670	Belongs to the BI1 family
FORC2_2876	COG0314	molybdopterin synthase activity
FORC2_2877	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC2_2878	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC2_2879	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC2_2880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC2_2881	COG4628	conserved protein (DUF2132)
FORC2_2882	COG0556	nucleotide-excision repair
FORC2_2884	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC2_2885	COG2226	methyltransferase
FORC2_2886	COG0156	8-amino-7-oxononanoate synthase activity
FORC2_2887	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC2_2889	COG2706	6-phosphogluconolactonase activity
FORC2_2890	COG0561	phosphatase activity
FORC2_2892	COG4149	molybdate abc transporter
FORC2_2893	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC2_2895	COG3585	molybdate ion transport
FORC2_2895	COG2005	Transcriptional regulator
FORC2_2896	COG1119	ATPase activity
FORC2_2898	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC2_2899	COG1085	galactose-1-phosphate uridylyltransferase
FORC2_2900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC2_2901	COG2017	converts alpha-aldose to the beta-anomer
FORC2_2904	COG0588	phosphoglycerate mutase activity
FORC2_2905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC2_2906	COG1230	cation diffusion facilitator family transporter
FORC2_2908	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC2_2909	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC2_2910	COG2885	chlorophyll binding
FORC2_2911	COG0823	Involved in the tonB-independent uptake of proteins
FORC2_2912	COG3064	Membrane
FORC2_2912	COG3064	Membrane
FORC2_2913	COG0848	biopolymer transport protein
FORC2_2914	COG0811	peptide transport
FORC2_2915	COG0824	Thioesterase
FORC2_2916	COG3790	cyd operon protein YbgE
FORC2_2917	COG4890	Cyd operon protein YbgT
FORC2_2918	COG1294	oxidase, subunit
FORC2_2919	COG1271	oxidase subunit
FORC2_2920	COG0737	Belongs to the 5'-nucleotidase family
FORC2_2921	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FORC2_2922	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC2_2923	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC2_2924	COG0567	Dehydrogenase, E1 component
FORC2_2926	COG1053	succinate dehydrogenase
FORC2_2927	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC2_2928	COG2009	succinate dehydrogenase
FORC2_2930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC2_2933	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC2_2934	COG1984	allophanate hydrolase subunit 2
FORC2_2935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC2_2936	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC2_2937	COG5212	phosphodiesterase
FORC2_2939	COG3272	Protein of unknown function (DUF1722)
FORC2_2940	COG1073	alpha beta
FORC2_2940	COG3064	Membrane
FORC2_2940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FORC2_2940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FORC2_2940	COG3064	Membrane
FORC2_2940	COG1073	alpha beta
FORC2_2941	COG2994	toxin metabolic process
FORC2_2945	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FORC2_2946	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FORC2_2947	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FORC2_2948	COG2205	protein histidine kinase activity
FORC2_2949	COG0745	RESPONSE REGULATOR receiver
FORC2_2951	COG0033	Phosphoglucomutase
FORC2_2952	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC2_2953	COG0596	Alpha beta hydrolase
FORC2_2955	COG0840	transmembrane signaling receptor activity
FORC2_2957	COG0735	belongs to the Fur family
FORC2_2961	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC2_2962	COG2190	(PTS) system
FORC2_2962	COG1263	PTS System
FORC2_2962	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_2963	COG0363	glucosamine-6-phosphate deaminase activity
FORC2_2964	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC2_2965	COG1940	carbohydrate kinase activity
FORC2_2965	COG1846	Transcriptional regulator
FORC2_2966	COG0647	UMP catabolic process
FORC2_2967	COG0367	asparagine synthase
FORC2_2968	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC2_2969	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC2_2970	COG1702	phosphate starvation-inducible protein PhoH
FORC2_2971	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC2_2972	COG4535	Mg2 and Co2 transporter CorC
FORC2_2973	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC2_2976	COG0765	amino acid transport
FORC2_2977	COG0765	amino acid transport
FORC2_2978	COG1126	abc transporter atp-binding protein
FORC2_2980	COG2888	peptidyl-tyrosine sulfation
FORC2_2981	COG0495	leucyl-tRNA aminoacylation
FORC2_2982	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC2_2983	COG1466	dna polymerase III delta subunit
FORC2_2984	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC2_2985	COG0799	negative regulation of ribosome biogenesis
FORC2_2987	COG0768	penicillin binding
FORC2_2988	COG0772	Belongs to the SEDS family
FORC2_2989	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC2_2990	COG1686	Belongs to the peptidase S11 family
FORC2_2991	COG2921	Belongs to the UPF0250 family
FORC2_2992	COG0321	lipoyl(octanoyl) transferase activity
FORC2_2993	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC2_2994	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC2_2995	COG3706	GGDEF domain
FORC2_2996	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC2_2997	COG1278	Cold shock
FORC2_2998	COG1278	Cold shock
FORC2_2999	COG2197	response regulator
FORC2_3001	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC2_3004	COG5265	(ABC) transporter
FORC2_3006	COG2986	histidine ammonia-lyase
FORC2_3007	COG2850	peptidyl-arginine hydroxylation
FORC2_3011	COG5002	protein histidine kinase activity
FORC2_3015	COG0656	L-ascorbic acid biosynthetic process
FORC2_3018	COG1902	pentaerythritol trinitrate reductase activity
FORC2_3019	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC2_3020	COG2501	S4 domain
FORC2_3021	COG0215	cysteine-tRNA ligase activity
FORC2_3022	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC2_3023	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC2_3024	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC2_3025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC2_3026	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC2_3027	COG4181	ATPase activity
FORC2_3028	COG2755	lipolytic protein G-D-S-L family
FORC2_3029	COG0300	oxidoreductase activity
FORC2_3030	COG3118	belongs to the thioredoxin family
FORC2_3031	COG0330	HflC and HflK could
FORC2_3032	COG1585	Membrane protein implicated in regulation of membrane protease activity
FORC2_3033	COG0789	Transcriptional regulator
FORC2_3034	COG2217	Heavy metal translocating P-type atpase
FORC2_3035	COG3735	TraB family
FORC2_3036	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC2_3037	COG0737	Belongs to the 5'-nucleotidase family
FORC2_3038	COG2223	nitrite transmembrane transporter activity
FORC2_3039	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC2_3039	COG4651	solute:proton antiporter activity
FORC2_3040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC2_3046	COG0438	transferase activity, transferring glycosyl groups
FORC2_3047	COG1442	glycosyl transferase family 8
FORC2_3047	COG1216	Glycosyl transferase, family 2
FORC2_3048	COG1216	Glycosyl transferase, family 2
FORC2_3048	COG1442	glycosyl transferase family 8
FORC2_3049	COG2244	polysaccharide biosynthetic process
FORC2_3050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC2_3051	COG0563	adenylate kinase activity
FORC2_3052	COG0326	Molecular chaperone. Has ATPase activity
FORC2_3053	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC2_3054	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC2_3056	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC2_3057	COG2832	Protein of unknown function (DUF454)
FORC2_3060	COG1196	nuclear chromosome segregation
FORC2_3060	COG3264	Mechanosensitive ion channel
FORC2_3061	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC2_3062	COG1309	transcriptional regulator
FORC2_3063	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_3064	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC2_3066	COG3457	Alanine racemase
FORC2_3067	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC2_3070	COG0254	rRNA binding
FORC2_3071	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC2_3072	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC2_3073	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC2_3079	COG3695	enzyme binding
FORC2_3080	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC2_3081	COG1946	Acyl-CoA thioesterase
FORC2_3082	COG0004	ammonium transporteR
FORC2_3083	COG0347	Belongs to the P(II) protein family
FORC2_3084	COG1132	(ABC) transporter
FORC2_3085	COG1132	(ABC) transporter
FORC2_3086	COG1522	sequence-specific DNA binding
FORC2_3088	COG0561	phosphatase activity
FORC2_3089	COG4533	DNA binding
FORC2_3090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC2_3091	COG0824	Thioesterase
FORC2_3092	COG1555	photosystem II stabilization
FORC2_3093	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC2_3094	COG0776	regulation of translation
FORC2_3095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC2_3096	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC2_3097	COG0740	serine-type endopeptidase activity
FORC2_3098	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC2_3099	COG0271	Belongs to the BolA IbaG family
FORC2_3100	COG3056	Lipoprotein
FORC2_3101	COG2223	nitrite transmembrane transporter activity
FORC2_3103	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC2_3104	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC2_3105	COG1845	cytochrome c oxidase, subunit III
FORC2_3106	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC2_3107	COG0109	protoheme IX farnesyltransferase activity
FORC2_3108	COG2814	Major facilitator Superfamily
FORC2_3109	COG1666	GTP binding
FORC2_3110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC2_3112	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC2_3112	COG0301	tRNA thio-modification
FORC2_3113	COG1722	exodeoxyribonuclease VII activity
FORC2_3114	COG0142	geranyltranstransferase activity
FORC2_3115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC2_3116	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC2_3117	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC2_3118	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC2_3119	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FORC2_3120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC2_3120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC2_3121	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC2_3123	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC2_3124	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC2_3125	COG1862	Preprotein translocase
FORC2_3126	COG0343	queuine tRNA-ribosyltransferase activity
FORC2_3128	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC2_3129	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC2_3130	COG0450	alkyl hydroperoxide reductase
FORC2_3133	COG0366	Alpha amylase catalytic
FORC2_3135	COG1114	Component of the transport system for branched-chain amino acids
FORC2_3137	COG5002	protein histidine kinase activity
FORC2_3138	COG0745	RESPONSE REGULATOR receiver
FORC2_3139	COG0420	3'-5' exonuclease activity
FORC2_3140	COG0419	ATPase involved in DNA repair
FORC2_3141	COG1940	carbohydrate kinase activity
FORC2_3142	COG2974	May be involved in recombination
FORC2_3143	COG3123	guanosine phosphorylase activity
FORC2_3144	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC2_3149	COG2226	methyltransferase
FORC2_3152	COG3459	Glycosyltransferase 36 associated
FORC2_3156	COG2188	Transcriptional regulator
FORC2_3157	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC2_3158	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC2_3161	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC2_3162	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC2_3163	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC2_3166	COG2964	Protein conserved in bacteria
FORC2_3167	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC2_3169	COG2991	Protein conserved in bacteria
FORC2_3170	COG1477	protein flavinylation
FORC2_3171	COG2871	sodium ion transport
FORC2_3172	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC2_3173	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC2_3174	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC2_3175	COG1805	sodium ion transport
FORC2_3176	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC2_3177	COG3034	peptidoglycan biosynthetic process
FORC2_3178	COG0121	glutamine amidotransferase
FORC2_3179	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC2_3180	COG1960	acyl-CoA dehydrogenase activity
FORC2_3181	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
FORC2_3184	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
FORC2_3185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FORC2_3186	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
FORC2_3187	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
FORC2_3188	COG0235	Class ii aldolase
FORC2_3189	COG0436	Aminotransferase
FORC2_3192	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC2_3194	COG0765	amino acid transport
FORC2_3195	COG0765	amino acid transport
FORC2_3202	COG2814	Major facilitator Superfamily
FORC2_3203	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FORC2_3205	COG1846	Transcriptional regulator
FORC2_3206	COG1538	Outer membrane efflux protein
FORC2_3207	COG1566	PFAM secretion protein HlyD family protein
FORC2_3208	COG2814	Major facilitator Superfamily
FORC2_3209	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC2_3210	COG3118	belongs to the thioredoxin family
FORC2_3212	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC2_3212	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC2_3212	COG1042	CoA-binding domain protein
FORC2_3213	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC2_3214	COG5544	Lipoprotein
FORC2_3215	COG0542	response to heat
FORC2_3217	COG0564	pseudouridine synthase activity
FORC2_3218	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC2_3219	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC2_3220	COG1605	Chorismate mutase
FORC2_3220	COG0077	Prephenate dehydratase
FORC2_3221	COG1605	Chorismate mutase
FORC2_3221	COG0287	Prephenate dehydrogenase
FORC2_3222	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC2_3223	COG3279	Response regulator of the LytR AlgR family
FORC2_3224	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC2_3225	COG3137	Salt-induced outer membrane protein
FORC2_3226	COG0335	large ribosomal subunit rRNA binding
FORC2_3227	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC2_3228	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC2_3229	COG0228	four-way junction DNA binding
FORC2_3230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC2_3231	COG4137	Cytochrome C assembly protein
FORC2_3232	COG4536	flavin adenine dinucleotide binding
FORC2_3233	COG1854	S-ribosylhomocysteine lyase activity
FORC2_3234	COG2918	glutathione biosynthetic process
FORC2_3235	COG1238	metal cluster binding
FORC2_3236	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC2_3237	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FORC2_3238	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC2_3239	COG2137	regulation of response to DNA damage stimulus
FORC2_3240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC2_3245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC2_3246	COG3958	Transketolase
FORC2_3247	COG3959	Transketolase, thiamine diphosphate binding domain
FORC2_3248	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_3249	COG1129	ABC transporter
FORC2_3251	COG1609	Transcriptional regulator
FORC2_3254	COG3381	protein complex oligomerization
FORC2_3255	COG3302	dmso reductase anchor subunit
FORC2_3256	COG0437	4 iron, 4 sulfur cluster binding
FORC2_3257	COG0243	molybdopterin cofactor binding
FORC2_3258	COG1454	alcohol dehydrogenase
FORC2_3259	COG0235	Class ii aldolase
FORC2_3260	COG0738	Major facilitator superfamily
FORC2_3262	COG1070	Carbohydrate kinase
FORC2_3264	COG1349	DNA-binding transcription factor activity
FORC2_3265	COG0235	Class ii aldolase
FORC2_3266	COG1349	DNA-binding transcription factor activity
FORC2_3269	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_3271	COG3623	hexulose-6-phosphate isomerase
FORC2_3272	COG1070	Carbohydrate kinase
FORC2_3273	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC2_3273	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FORC2_3275	COG0559	Belongs to the binding-protein-dependent transport system permease family
FORC2_3276	COG4177	L-phenylalanine transmembrane transporter activity
FORC2_3277	COG1137	ATPase activity
FORC2_3278	COG0410	ABC transporter
FORC2_3289	COG0640	Transcriptional regulator
FORC2_3290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC2_3292	COG3665	Urea carboxylase-associated protein
FORC2_3293	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC2_3294	COG1126	abc transporter atp-binding protein
FORC2_3295	COG0765	amino acid transport
FORC2_3298	COG3048	D-serine ammonia-lyase activity
FORC2_3299	COG2610	gluconate transmembrane transporter activity
FORC2_3300	COG0583	DNA-binding transcription factor activity
FORC2_3302	COG1028	Short-chain dehydrogenase reductase Sdr
FORC2_3306	COG1538	Outer membrane efflux protein
FORC2_3308	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_3314	COG3539	Fimbrial protein
FORC2_3315	COG3539	Fimbrial protein
FORC2_3317	COG3121	Chaperone
FORC2_3318	COG3188	usher protein
FORC2_3323	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC2_3324	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC2_3325	COG4942	peptidase
FORC2_3325	COG1388	LysM domain
FORC2_3326	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC2_3327	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC2_3328	COG0585	pseudouridine synthase activity
FORC2_3329	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC2_3331	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC2_3333	COG0765	amino acid transport
FORC2_3336	COG0529	Catalyzes the synthesis of activated sulfate
FORC2_3337	COG2895	sulfate adenylyltransferase (ATP) activity
FORC2_3338	COG0175	sulfate reduction
FORC2_3339	COG1648	precorrin-2 dehydrogenase activity
FORC2_3339	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC2_3340	COG2234	aminopeptidase activity
FORC2_3343	COG0175	sulfate reduction
FORC2_3344	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC2_3345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC2_3346	COG0720	synthase
FORC2_3347	COG0602	queuosine metabolic process
FORC2_3352	COG0148	phosphopyruvate hydratase activity
FORC2_3353	COG0504	CTP synthase activity
FORC2_3354	COG3956	TIGRFAM MazG family protein
FORC2_3355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC2_3356	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC2_3357	COG2205	protein histidine kinase activity
FORC2_3357	COG4999	Histidine kinase
FORC2_3357	COG3437	response regulator, receiver
FORC2_3357	COG3850	Histidine kinase
FORC2_3358	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC2_3359	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC2_3360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC2_3362	COG2860	membrane
FORC2_3363	COG0316	Belongs to the HesB IscA family
FORC2_3365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC2_3366	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC2_3367	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC2_3368	COG1120	ATPase activity
FORC2_3369	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC2_3370	COG1643	Atp-dependent helicase
FORC2_3371	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FORC2_3372	COG1489	DNA binding
FORC2_3373	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC2_3376	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC2_3377	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC2_3378	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC2_3379	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FORC2_3380	COG0726	polysaccharide deacetylase
FORC2_3381	COG0842	Transport permease protein
FORC2_3382	COG1131	(ABC) transporter
FORC2_3383	COG0288	reversible hydration of carbon dioxide
FORC2_3384	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FORC2_3386	COG2132	Multicopper oxidase
FORC2_3388	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FORC2_3389	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
FORC2_3394	COG0697	spore germination
FORC2_3395	COG3112	Uncharacterised protein family (UPF0231)
FORC2_3400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC2_3401	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC2_3402	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC2_3403	COG2186	Transcriptional regulator
FORC2_3404	COG1113	amino acid transport
FORC2_3405	COG3725	Membrane protein required for beta-lactamase induction
FORC2_3408	COG4969	Belongs to the N-Me-Phe pilin family
FORC2_3409	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC2_3410	COG1459	type II secretion system
FORC2_3411	COG0516	GMP reductase activity
FORC2_3412	COG0237	dephospho-CoA kinase activity
FORC2_3413	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC2_3414	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC2_3415	COG0494	nUDIX hydrolase
FORC2_3416	COG0653	protein targeting
FORC2_3420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC2_3421	COG0849	cell division
FORC2_3422	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC2_3424	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC2_3425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC2_3426	COG0772	Belongs to the SEDS family
FORC2_3428	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC2_3429	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC2_3430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC2_3431	COG0768	penicillin binding
FORC2_3432	COG3116	cell division
FORC2_3433	COG0275	rRNA processing
FORC2_3434	COG2001	Belongs to the MraZ family
FORC2_3436	COG1609	Transcriptional regulator
FORC2_3438	COG0028	Belongs to the TPP enzyme family
FORC2_3439	COG1022	Amp-dependent synthetase and ligase
FORC2_3441	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC2_3442	COG0473	3-isopropylmalate dehydrogenase activity
FORC2_3443	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC2_3446	COG3033	Beta-eliminating lyase
FORC2_3447	COG0814	amino acid
FORC2_3448	COG2814	Major facilitator Superfamily
FORC2_3451	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC2_3452	COG4533	DNA binding
FORC2_3455	COG4143	(ABC) transporter
FORC2_3456	COG1178	ABC-type Fe3 transport system permease component
FORC2_3458	COG0586	Pfam SNARE associated Golgi protein
FORC2_3459	COG0417	DNA replication proofreading
FORC2_3460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC2_3462	COG0564	pseudouridine synthase activity
FORC2_3463	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC2_3464	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC2_3465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC2_3466	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC2_3467	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC2_3468	COG2967	ApaG domain
FORC2_3469	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC2_3470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC2_3471	COG3610	response to peptide
FORC2_3472	COG2966	Psort location CytoplasmicMembrane, score
FORC2_3473	COG1280	lysine exporter protein (LysE YggA)
FORC2_3474	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC2_3475	COG0505	Belongs to the CarA family
FORC2_3476	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC2_3477	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC2_3478	COG1047	Peptidyl-prolyl cis-trans
FORC2_3479	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC2_3480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC2_3481	COG0196	riboflavin kinase activity
FORC2_3482	COG0268	Binds directly to 16S ribosomal RNA
FORC2_3483	COG0583	DNA-binding transcription factor activity
FORC2_3484	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC2_3485	COG0484	heat shock protein binding
FORC2_3487	COG1584	GPR1 FUN34 yaaH family protein
FORC2_3489	COG0477	Major facilitator Superfamily
FORC2_3490	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC2_3491	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC2_3492	COG3022	response to hydroperoxide
FORC2_3494	COG0083	homoserine kinase activity
FORC2_3497	COG0745	RESPONSE REGULATOR receiver
FORC2_3498	COG3045	CreA protein
FORC2_3499	COG3708	Transcriptional regulator
FORC2_3499	COG2207	Transcriptional regulator
FORC2_3500	COG0406	alpha-ribazole phosphatase activity
FORC2_3501	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC2_3502	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC2_3503	COG0741	lytic transglycosylase activity
FORC2_3504	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FORC2_3506	COG2199	diguanylate cyclase activity
FORC2_3507	COG2885	chlorophyll binding
FORC2_3508	COG0488	(ABC) transporter
FORC2_3510	COG0604	alcohol dehydrogenase
FORC2_3516	COG0560	Phosphoserine phosphatase
FORC2_3517	COG3726	membrane protein affecting hemolysin expression
FORC2_3518	COG0813	purine-nucleoside phosphorylase activity
FORC2_3519	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC2_3520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC2_3521	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC2_3522	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC2_3523	COG0084	hydrolase, TatD family'
FORC2_3524	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC2_3525	COG2823	Periplasmic or secreted lipoprotein
FORC2_3526	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC2_3527	COG0456	acetyltransferase
FORC2_3528	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FORC2_3529	COG2813	Specifically methylates the guanine in position
FORC2_3530	COG0667	Aldo Keto reductase
FORC2_3533	COG3706	GGDEF domain
FORC2_3534	COG4772	TonB-dependent receptor
FORC2_3541	COG3284	Transcriptional regulator
FORC2_3547	COG2192	nodulation
FORC2_3549	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FORC2_3549	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC2_3549	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC2_3550	COG1461	Dihydroxyacetone kinase
FORC2_3551	COG2376	Dihydroxyacetone kinase
FORC2_3553	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC2_3554	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_3555	COG2235	arginine
FORC2_3558	COG0859	PFAM glycosyl transferase family 9
FORC2_3559	COG1070	Carbohydrate kinase
FORC2_3560	COG2390	Transcriptional regulator
FORC2_3561	COG1129	ABC transporter
FORC2_3562	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_3563	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_3564	COG1879	ABC-type sugar transport system periplasmic component
FORC2_3565	COG1830	Aldolase
FORC2_3566	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC2_3582	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC2_3589	COG0582	viral genome integration into host DNA
FORC2_3590	COG0795	lipopolysaccharide-transporting ATPase activity
FORC2_3591	COG0795	lipopolysaccharide-transporting ATPase activity
FORC2_3592	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC2_3593	COG2927	DNA polymerase III (CHI subunit)
FORC2_3596	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FORC2_3598	COG2731	YhcH YjgK YiaL family protein
FORC2_3600	COG0601	transmembrane transport
FORC2_3602	COG0444	Belongs to the ABC transporter superfamily
FORC2_3603	COG4608	Belongs to the ABC transporter superfamily
FORC2_3606	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC2_3607	COG0583	DNA-binding transcription factor activity
FORC2_3612	COG2188	Transcriptional regulator
FORC2_3613	COG3624	Phosphonate C-P lyase system protein PhnG
FORC2_3614	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FORC2_3615	COG3626	phosphonate metabolism
FORC2_3616	COG3627	carbon phosphorus lyase activity
FORC2_3617	COG4107	phosphonate C-P lyase system protein PhnK
FORC2_3618	COG4778	phosphonate C-P lyase system protein PhnL
FORC2_3619	COG3454	Phosphonate metabolism
FORC2_3620	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FORC2_3621	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FORC2_3622	COG0702	epimerase
FORC2_3624	COG3787	Belongs to the UPF0306 family
FORC2_3626	COG3842	ATPase activity
FORC2_3627	COG0395	ABC-type sugar transport system, permease component
FORC2_3629	COG1653	transport
FORC2_3632	COG1982	Orn Lys Arg decarboxylase major
FORC2_3633	COG0531	amino acid
FORC2_3634	COG2827	Endonuclease containing a URI domain
FORC2_3635	COG3153	acetyltransferase
FORC2_3639	COG3681	Belongs to the UPF0597 family
FORC2_3640	COG0814	amino acid
FORC2_3642	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC2_3643	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC2_3644	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FORC2_3646	COG0513	Belongs to the DEAD box helicase family
FORC2_3648	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC2_3649	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC2_3650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC2_3651	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC2_3652	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC2_3653	COG0195	Participates in both transcription termination and antitermination
FORC2_3654	COG0779	Required for maturation of 30S ribosomal subunits
FORC2_3655	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC2_3656	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC2_3657	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC2_3658	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC2_3659	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC2_3660	COG1534	Rna-binding protein
FORC2_3661	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC2_3662	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC2_3663	COG0745	RESPONSE REGULATOR receiver
FORC2_3664	COG0642	Histidine kinase
FORC2_3665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC2_3666	COG0697	spore germination
FORC2_3667	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FORC2_3668	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC2_3669	COG0142	geranyltranstransferase activity
FORC2_3671	COG3423	Transcriptional regulator
FORC2_3672	COG0039	L-malate dehydrogenase activity
FORC2_3673	COG1438	arginine binding
FORC2_3675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC2_3676	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC2_3678	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC2_3679	COG2105	PFAM AIG2 family protein
FORC2_3682	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC2_3683	COG1253	flavin adenine dinucleotide binding
FORC2_3685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC2_3686	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC2_3687	COG0737	Belongs to the 5'-nucleotidase family
FORC2_3689	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC2_3690	COG3061	Opacity-associated protein A
FORC2_3692	COG0359	binds to the 23S rRNA
FORC2_3693	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FORC2_3694	COG2965	DNA replication, synthesis of RNA primer
FORC2_3695	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC2_3697	COG1073	alpha beta
FORC2_3698	COG3650	response to hydrogen peroxide
FORC2_3699	COG1960	acyl-CoA dehydrogenase activity
FORC2_3700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC2_3701	COG0557	exoribonuclease II activity
FORC2_3702	COG1959	2 iron, 2 sulfur cluster binding
FORC2_3703	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC2_3704	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC2_3705	COG0330	HflC and HflK could
FORC2_3706	COG0330	HflC and HflK could
FORC2_3707	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC2_3708	COG1923	regulation of RNA biosynthetic process
FORC2_3709	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC2_3710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC2_3711	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC2_3712	COG0802	atpase or kinase
FORC2_3713	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC2_3713	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC2_3714	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC2_3715	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC2_3716	COG1162	GTPase activity
FORC2_3717	COG0688	phosphatidylethanolamine metabolic process
FORC2_3718	COG1511	domain protein
FORC2_3718	COG3264	Mechanosensitive ion channel
FORC2_3719	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC2_3720	COG1053	succinate dehydrogenase
FORC2_3721	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC2_3722	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC2_3723	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC2_3725	COG2076	Multidrug Resistance protein
FORC2_3727	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC2_3732	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC2_3735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC2_3737	COG4232	protein-disulfide reductase activity
FORC2_3738	COG1929	Belongs to the glycerate kinase type-1 family
FORC2_3739	COG1309	transcriptional regulator
FORC2_3740	COG1882	Formate acetyltransferase
FORC2_3741	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC2_3742	COG0814	amino acid
FORC2_3745	COG3721	Heme iron utilization protein
FORC2_3746	COG0702	epimerase
FORC2_3749	COG3720	iron ion transport
FORC2_3750	COG4558	Periplasmic binding protein
FORC2_3751	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC2_3752	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC2_3753	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC2_3755	COG4774	siderophore transport
FORC2_3756	COG3264	Mechanosensitive ion channel
FORC2_3756	COG1511	domain protein
FORC2_3757	COG0612	Peptidase, M16
FORC2_3758	COG4178	(ABC) transporter
FORC2_3759	COG4771	TonB-dependent receptor
FORC2_3760	COG3712	iron ion homeostasis
FORC2_3763	COG0425	Belongs to the sulfur carrier protein TusA family
FORC2_3764	COG2391	methyltransferase activity
FORC2_3795	COG2205	protein histidine kinase activity
FORC2_3795	COG0784	Response regulator, receiver
FORC2_3796	COG2197	response regulator
FORC2_3797	COG1301	dicarboxylic acid transport
FORC2_3798	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC2_3799	COG3162	membrane
FORC2_3800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC2_3802	COG0138	bifunctional purine biosynthesis protein purh
FORC2_3803	COG0151	Belongs to the GarS family
FORC2_3806	COG3068	Protein conserved in bacteria
FORC2_3807	COG1515	deoxyribonuclease V activity
FORC2_3808	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC2_3810	COG2816	NAD+ diphosphatase activity
FORC2_3811	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC2_3812	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC2_3814	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC2_3815	COG2104	thiamine diphosphate biosynthetic process
FORC2_3816	COG2022	thiamine diphosphate biosynthetic process
FORC2_3818	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC2_3819	COG0085	RNA polymerase activity
FORC2_3820	COG0222	ribosome binding
FORC2_3821	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC2_3822	COG0081	regulation of translation
FORC2_3823	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC2_3824	COG0250	Participates in transcription elongation, termination and antitermination
FORC2_3825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC2_3826	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC2_3828	COG1072	(Pantothenic acid kinase))
FORC2_3829	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FORC2_3829	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FORC2_3832	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC2_3833	COG1739	Uncharacterized protein family UPF0029
FORC2_3834	COG0006	proline dipeptidase activity
FORC2_3835	COG1024	Enoyl-CoA hydratase
FORC2_3835	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC2_3836	COG0183	Belongs to the thiolase family
FORC2_3838	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC2_3842	COG0805	protein transport
FORC2_3843	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC2_3844	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC2_3845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC2_3847	COG2226	methyltransferase
FORC2_3848	COG1322	Protein conserved in bacteria
FORC2_3849	COG0586	Pfam SNARE associated Golgi protein
FORC2_3850	COG1966	Carbon starvation protein
FORC2_3852	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC2_3853	COG0412	Dienelactone hydrolase
FORC2_3854	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC2_3855	COG0583	DNA-binding transcription factor activity
FORC2_3857	COG0679	Auxin Efflux Carrier
FORC2_3858	COG0584	glycerophosphoryl diester phosphodiesterase
FORC2_3859	COG3842	ATPase activity
FORC2_3860	COG0395	ABC-type sugar transport system, permease component
FORC2_3861	COG1175	transmembrane transport
FORC2_3862	COG1653	transport
FORC2_3869	COG0410	ABC transporter
FORC2_3870	COG0411	ABC transporter
FORC2_3871	COG4177	L-phenylalanine transmembrane transporter activity
FORC2_3872	COG0559	Belongs to the binding-protein-dependent transport system permease family
FORC2_3873	COG0683	leucine binding
FORC2_3876	COG2177	Part of the ABC transporter FtsEX involved in
FORC2_3877	COG2884	Cell division ATP-binding protein ftsE
FORC2_3878	COG0552	protein localization to endoplasmic reticulum
FORC2_3879	COG0742	ribosomal rna small subunit methyltransferase
FORC2_3880	COG3776	membrane
FORC2_3883	COG3714	YhhN family
FORC2_3884	COG2217	Heavy metal translocating P-type atpase
FORC2_3885	COG0425	Belongs to the sulfur carrier protein TusA family
FORC2_3886	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC2_3888	COG0247	lactate metabolic process
FORC2_3889	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
FORC2_3890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC2_3891	COG2271	Major facilitator Superfamily
FORC2_3892	COG0584	glycerophosphoryl diester phosphodiesterase
FORC2_3893	COG0561	phosphatase activity
FORC2_3894	COG2267	carboxylic ester hydrolase activity
FORC2_3895	COG1280	lysine exporter protein (LysE YggA)
FORC2_3896	COG1280	lysine exporter protein (LysE YggA)
FORC2_3897	COG0514	ATP-dependent DNA helicase (RecQ)
FORC2_3898	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC2_3899	COG2050	protein possibly involved in aromatic compounds catabolism
FORC2_3901	COG0598	Magnesium transport protein CorA
FORC2_3902	COG5564	TIM-barrel signal transduction protein
FORC2_3903	COG5441	Belongs to the UPF0261 family
FORC2_3905	COG0210	DNA helicase
FORC2_3906	COG1011	Hydrolase
FORC2_3907	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC2_3908	COG3159	Protein conserved in bacteria
FORC2_3909	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC2_3910	COG5567	small periplasmic lipoprotein
FORC2_3911	COG1965	Belongs to the frataxin family
FORC2_3912	COG3072	Adenylate cyclase
FORC2_3913	COG0181	hydroxymethylbilane synthase activity
FORC2_3914	COG1587	Uroporphyrinogen-III synthase
FORC2_3915	COG2959	enzyme of heme biosynthesis
FORC2_3916	COG3071	HemY protein
FORC2_3917	COG1113	amino acid transport
FORC2_3920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC2_3921	COG2244	polysaccharide biosynthetic process
FORC2_3922	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC2_3923	COG0456	acetyltransferase
FORC2_3924	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FORC2_3925	COG1088	dTDP-glucose 4,6-dehydratase activity
FORC2_3926	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FORC2_3927	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC2_3928	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FORC2_3929	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC2_3930	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC2_3931	COG3118	belongs to the thioredoxin family
FORC2_3933	COG0248	Ppx GppA phosphatase
FORC2_3936	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC2_3938	COG3121	Chaperone
FORC2_3941	COG3121	Chaperone
FORC2_3944	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC2_3945	COG0583	DNA-binding transcription factor activity
FORC2_3947	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORC2_3948	COG0129	dihydroxy-acid dehydratase activity
FORC2_3949	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC2_3950	COG3978	acetolactate synthase activity
FORC2_3953	COG3085	chromosome segregation
FORC2_3954	COG0583	DNA-binding transcription factor activity
FORC2_3955	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_3956	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_3957	COG1129	ABC transporter
FORC2_3958	COG1879	ABC-type sugar transport system periplasmic component
FORC2_3959	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC2_3961	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC2_3962	COG5544	Lipoprotein
FORC2_3963	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC2_3965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC2_3967	COG1309	transcriptional regulator
FORC2_3968	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC2_3970	COG0678	peroxiredoxin activity
FORC2_3970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC2_3971	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC2_3979	COG1629	transport
FORC2_3980	COG0165	Argininosuccinate lyase
FORC2_3981	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC2_3982	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC2_3984	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC2_3986	COG0527	aspartate kinase activity
FORC2_3986	COG0460	homoserine dehydrogenase
FORC2_3987	COG0626	cystathionine gamma-synthase activity
FORC2_3988	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FORC2_3989	COG0254	rRNA binding
FORC2_3990	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC2_3991	COG1609	Transcriptional regulator
FORC2_3992	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC2_3993	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC2_3994	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC2_3995	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC2_3996	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC2_3997	COG3074	FtsZ-dependent cytokinesis
FORC2_3999	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC2_4000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC2_4001	COG1494	fructose-1,6-bisphosphatase
FORC2_4002	COG2814	Major facilitator Superfamily
FORC2_4004	COG3152	Membrane
FORC2_4006	COG0149	triose-phosphate isomerase activity
FORC2_4008	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FORC2_4010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC2_4011	COG3678	ATP-independent chaperone mediated protein folding
FORC2_4012	COG0745	RESPONSE REGULATOR receiver
FORC2_4013	COG2205	protein histidine kinase activity
FORC2_4014	COG2169	Transcriptional regulator
FORC2_4014	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC2_4015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC2_4016	COG1045	serine acetyltransferase
FORC2_4017	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC2_4018	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC2_4019	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC2_4020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC2_4021	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC2_4022	COG4942	peptidase
FORC2_4023	COG2861	carbohydrate metabolic process
FORC2_4024	COG1063	alcohol dehydrogenase
FORC2_4025	COG0156	8-amino-7-oxononanoate synthase activity
FORC2_4026	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC2_4027	COG0859	PFAM glycosyl transferase family 9
FORC2_4028	COG0859	PFAM glycosyl transferase family 9
FORC2_4029	COG1519	Transferase
FORC2_4031	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC2_4032	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC2_4033	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FORC2_4034	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC2_4035	COG2003	Belongs to the UPF0758 family
FORC2_4036	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC2_4037	COG0756	dUTP diphosphatase activity
FORC2_4038	COG1309	transcriptional regulator
FORC2_4039	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC2_4040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC2_4041	COG1561	YicC-like family, N-terminal region
FORC2_4044	COG5001	Diguanylate cyclase
FORC2_4045	COG1024	Enoyl-CoA hydratase
FORC2_4046	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC2_4048	COG2860	membrane
FORC2_4049	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC2_4051	COG1758	RNA polymerase activity
FORC2_4052	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC2_4053	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC2_4054	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC2_4055	COG0786	glutamate:sodium symporter activity
FORC2_4056	COG2233	PERMEase
FORC2_4057	COG2982	Protein involved in outer membrane biogenesis
FORC2_4061	COG3423	Transcriptional regulator
FORC2_4062	COG0456	acetyltransferase
FORC2_4063	COG1490	D-aminoacyl-tRNA deacylase activity
FORC2_4064	COG1295	ribonuclease BN
FORC2_4065	COG1011	Hydrolase
FORC2_4067	COG0174	glutamine synthetase
FORC2_4068	COG3852	Histidine kinase
FORC2_4070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC2_4071	COG3078	GTPase activator activity
FORC2_4072	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC2_4073	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC2_4073	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC2_4074	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC2_4075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC2_4076	COG3084	Protein conserved in bacteria
FORC2_4078	COG1763	Mo-molybdopterin cofactor biosynthetic process
FORC2_4079	COG2186	Transcriptional regulator
FORC2_4080	COG0477	Major facilitator Superfamily
FORC2_4081	COG1609	Transcriptional regulator
FORC2_4082	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC2_4083	COG1879	ABC-type sugar transport system periplasmic component
FORC2_4084	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC2_4086	COG1869	D-ribose catabolic process
FORC2_4087	COG3158	transport of potassium into the cell
FORC2_4088	COG0714	Associated with various cellular activities
FORC2_4089	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC2_4091	COG2502	aspartate--ammonia ligase
FORC2_4092	COG1522	sequence-specific DNA binding
FORC2_4093	COG0716	FMN binding
FORC2_4094	COG0445	tRNA wobble uridine modification
FORC2_4095	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC2_4096	COG3312	ion transport
FORC2_4097	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC2_4099	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FORC2_4100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC2_4101	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC2_4102	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC2_4103	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC2_4104	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC2_4105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC2_4106	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC2_4107	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC2_4108	COG0573	inorganic phosphate transmembrane transporter activity
FORC2_4109	COG0581	inorganic phosphate transmembrane transporter activity
FORC2_4111	COG0704	Plays a role in the regulation of phosphate uptake
FORC2_4113	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC2_4114	COG0765	amino acid transport
FORC2_4115	COG0765	amino acid transport
FORC2_4116	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC2_4117	COG2252	PERMEase
FORC2_4120	COG4191	Histidine kinase
FORC2_4121	COG0431	NADPH-dependent FMN reductase
FORC2_4122	COG0840	transmembrane signaling receptor activity
FORC2_4123	COG2011	ABC-type metal ion transport system permease component
FORC2_4126	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC2_4127	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC2_4128	COG0706	membrane insertase activity
FORC2_4130	COG0594	ribonuclease P activity
FORC2_4131	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FORC2_p003	COG3547	Transposase (IS116 IS110 IS902 family)
FORC2_p008	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC2_p062	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC2_p063	COG3715	PTS system
FORC2_p064	COG3716	PTS system mannose fructose sorbose family IID component
FORC2_p069	COG5492	domain, Protein
FORC2_p100	COG3547	Transposase (IS116 IS110 IS902 family)
FORC2_p102	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family