locus-tag	class	description
LC20_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LC20_00002	COG0592	DNA-directed DNA polymerase activity
LC20_00005	COG0187	DNA topoisomerase II activity
LC20_00006	COG0561	phosphatase activity
LC20_00008	COG3121	Chaperone
LC20_00009	COG3188	usher protein
LC20_00012	COG2423	ornithine cyclodeaminase activity
LC20_00015	COG0823	Involved in the tonB-independent uptake of proteins
LC20_00016	COG5645	(Lipo)protein
LC20_00021	COG3977	Valine--pyruvate aminotransferase
LC20_00023	COG0366	Alpha amylase catalytic
LC20_00029	COG0456	acetyltransferase
LC20_00030	COG2818	Glycosylase
LC20_00032	COG0752	glycyl-tRNA synthetase alpha subunit
LC20_00033	COG0751	glycine-tRNA ligase activity
LC20_00035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_00035	COG2213	PTS system mannitol-specific
LC20_00036	COG0246	Mannitol dehydrogenase
LC20_00037	COG3722	fumarate hydratase activity
LC20_00039	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_00041	COG2258	MOSC domain
LC20_00042	COG0840	transmembrane signaling receptor activity
LC20_00043	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LC20_00044	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LC20_00045	COG3383	formate dehydrogenase (NAD+) activity
LC20_00045	COG0243	molybdopterin cofactor binding
LC20_00046	COG0243	molybdopterin cofactor binding
LC20_00046	COG3383	formate dehydrogenase (NAD+) activity
LC20_00047	COG0437	4 iron, 4 sulfur cluster binding
LC20_00048	COG2864	formate dehydrogenase
LC20_00049	COG3058	Necessary for formate dehydrogenase activity
LC20_00050	COG1921	L-seryl-tRNASec selenium transferase activity
LC20_00051	COG3276	selenocysteine insertion sequence binding
LC20_00053	COG3274	enterobacterial common antigen metabolic process
LC20_00055	COG1335	isochorismatase
LC20_00056	COG3121	Chaperone
LC20_00057	COG1070	Carbohydrate kinase
LC20_00058	COG2115	Belongs to the xylose isomerase family
LC20_00059	COG4213	ABC transporter substrate-binding protein
LC20_00061	COG4214	carbohydrate transport
LC20_00062	COG1609	Transcriptional regulator
LC20_00062	COG2207	Transcriptional regulator
LC20_00064	COG0582	viral genome integration into host DNA
LC20_00070	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
LC20_00071	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LC20_00082	COG2003	Belongs to the UPF0758 family
LC20_00093	COG1393	Belongs to the ArsC family
LC20_00098	COG1609	Transcriptional regulator
LC20_00100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LC20_00101	COG2986	histidine ammonia-lyase
LC20_00106	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LC20_00107	COG0463	Glycosyl transferase, family 2
LC20_00108	COG1090	epimerase
LC20_00111	COG1764	response to oxidative stress
LC20_00112	COG2194	sulfuric ester hydrolase activity
LC20_00113	COG2197	response regulator
LC20_00114	COG3851	Histidine kinase
LC20_00118	COG2831	hemolysin activation secretion protein
LC20_00122	COG3210	domain, Protein
LC20_00125	COG0747	negative chemotaxis
LC20_00126	COG0601	transmembrane transport
LC20_00127	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LC20_00128	COG0444	Belongs to the ABC transporter superfamily
LC20_00129	COG4608	Belongs to the ABC transporter superfamily
LC20_00134	COG2194	sulfuric ester hydrolase activity
LC20_00140	COG1192	Involved in chromosome partitioning
LC20_00142	COG1215	transferase activity, transferring glycosyl groups
LC20_00144	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LC20_00145	COG3118	belongs to the thioredoxin family
LC20_00145	COG0457	Tetratricopeptide repeat
LC20_00146	COG2199	diguanylate cyclase activity
LC20_00146	COG2200	EAL domain
LC20_00147	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LC20_00150	COG1301	dicarboxylic acid transport
LC20_00151	COG0612	Peptidase, M16
LC20_00152	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_00153	COG1942	4-Oxalocrotonate Tautomerase
LC20_00155	COG2200	EAL domain
LC20_00156	COG2982	Protein involved in outer membrane biogenesis
LC20_00159	COG0477	Major facilitator Superfamily
LC20_00160	COG1295	ribonuclease BN
LC20_00162	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_00164	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LC20_00167	COG0742	ribosomal rna small subunit methyltransferase
LC20_00170	COG0589	response to stress
LC20_00172	COG0306	phosphate transporter
LC20_00182	COG3799	methylaspartate ammonia-lyase activity
LC20_00183	COG4865	methylaspartate mutase activity
LC20_00185	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LC20_00192	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_00192	COG1648	precorrin-2 dehydrogenase activity
LC20_00194	COG0583	DNA-binding transcription factor activity
LC20_00197	COG0561	phosphatase activity
LC20_00201	COG2814	Major facilitator Superfamily
LC20_00214	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_00217	COG0673	inositol 2-dehydrogenase activity
LC20_00218	COG1082	Xylose isomerase domain protein TIM barrel
LC20_00219	COG1247	-acetyltransferase
LC20_00222	COG1741	Belongs to the pirin family
LC20_00223	COG1609	Transcriptional regulator
LC20_00224	COG2610	gluconate transmembrane transporter activity
LC20_00226	COG3265	gluconokinase activity
LC20_00227	COG2095	MarC family integral membrane protein
LC20_00228	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LC20_00234	COG3275	phosphorelay sensor kinase activity
LC20_00236	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LC20_00240	COG0297	glycogen (starch) synthase activity
LC20_00241	COG0058	SHG alpha-glucan phosphorylase activity
LC20_00242	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LC20_00244	COG1349	DNA-binding transcription factor activity
LC20_00245	COG0705	Rhomboid family
LC20_00248	COG2909	trisaccharide binding
LC20_00249	COG0058	SHG alpha-glucan phosphorylase activity
LC20_00250	COG1640	4-alpha-glucanotransferase
LC20_00251	COG0316	Belongs to the HesB IscA family
LC20_00251	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LC20_00252	COG1040	competence protein
LC20_00253	COG0596	Alpha beta hydrolase
LC20_00257	COG1918	ferrous iron import across plasma membrane
LC20_00262	COG0745	RESPONSE REGULATOR receiver
LC20_00264	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LC20_00266	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LC20_00267	COG1011	Hydrolase
LC20_00269	COG0494	nUDIX hydrolase
LC20_00270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LC20_00275	COG4796	Type ii and iii secretion system protein
LC20_00277	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LC20_00281	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LC20_00283	COG0180	Tryptophanyl-tRNA synthetase
LC20_00284	COG1648	precorrin-2 dehydrogenase activity
LC20_00284	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_00286	COG2146	nitrite reductase [NAD(P)H] activity
LC20_00287	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LC20_00290	COG0402	S-adenosylhomocysteine deaminase activity
LC20_00291	COG0738	Major facilitator superfamily
LC20_00296	COG1486	melibiose metabolic process
LC20_00297	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LC20_00298	COG0433	COG0433 Predicted ATPase
LC20_00301	COG1289	transmembrane transporter activity
LC20_00303	COG1765	OsmC-like protein
LC20_00304	COG3954	Phosphoribulokinase
LC20_00305	COG3089	Belongs to the UPF0270 family
LC20_00306	COG0429	hydrolase of the alpha beta-hydrolase fold
LC20_00310	COG4521	taurine ABC transporter
LC20_00312	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LC20_00313	COG2175	clavaminate synthase activity
LC20_00315	COG0488	(ABC) transporter
LC20_00316	COG2249	NAD(P)H dehydrogenase (quinone) activity
LC20_00318	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LC20_00319	COG1047	Peptidyl-prolyl cis-trans
LC20_00320	COG2900	Belongs to the SlyX family
LC20_00321	COG0545	Peptidyl-prolyl cis-trans isomerase
LC20_00322	COG2964	Protein conserved in bacteria
LC20_00324	COG2923	Belongs to the DsrF TusC family
LC20_00325	COG2168	tRNA wobble position uridine thiolation
LC20_00326	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LC20_00327	COG0049	tRNA binding
LC20_00335	COG0051	transcription antitermination factor activity, RNA binding
LC20_00336	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LC20_00337	COG0088	Forms part of the polypeptide exit tunnel
LC20_00338	COG0089	rRNA binding
LC20_00342	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LC20_00343	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LC20_00344	COG0255	Belongs to the universal ribosomal protein uL29 family
LC20_00345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LC20_00348	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LC20_00349	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LC20_00351	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LC20_00353	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LC20_00354	COG1841	ribosomal large subunit assembly
LC20_00355	COG0200	Binds to the 23S rRNA
LC20_00356	COG0201	protein transport
LC20_00357	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LC20_00358	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LC20_00359	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LC20_00360	COG0202	RNA polymerase activity
LC20_00361	COG0203	ribosomal protein L17
LC20_00363	COG0789	Transcriptional regulator
LC20_00364	COG3036	rescue of stalled ribosome
LC20_00365	COG1970	mechanosensitive ion channel activity
LC20_00366	COG0569	domain protein
LC20_00367	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LC20_00367	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LC20_00368	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LC20_00369	COG0242	peptide deformylase activity
LC20_00370	COG0758	DNA mediated transformation
LC20_00376	COG5301	cellulose 1,4-beta-cellobiosidase activity
LC20_00416	COG4974	Belongs to the 'phage' integrase family
LC20_00419	COG0551	DNA topoisomerase type I activity
LC20_00420	COG0009	L-threonylcarbamoyladenylate synthase
LC20_00421	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LC20_00422	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LC20_00426	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LC20_00427	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LC20_00428	COG2224	Isocitrate lyase
LC20_00429	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LC20_00433	COG0527	aspartate kinase activity
LC20_00438	COG3833	ABC-type maltose transport systems, permease component
LC20_00439	COG1175	transmembrane transport
LC20_00440	COG2182	Extracellular solute-binding protein
LC20_00442	COG4580	involved in the transport of maltose and maltodextrins
LC20_00446	COG3161	chorismate lyase activity
LC20_00447	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LC20_00448	COG2937	Belongs to the GPAT DAPAT family
LC20_00449	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LC20_00450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LC20_00451	COG3237	CsbD-like
LC20_00453	COG0735	belongs to the Fur family
LC20_00463	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LC20_00464	COG5532	Uncharacterized conserved protein (DUF2303)
LC20_00468	COG0681	Belongs to the peptidase S26 family
LC20_00472	COG4626	Terminase
LC20_00472	COG1802	Transcriptional regulator
LC20_00473	COG4725	Belongs to the MT-A70-like family
LC20_00475	COG3646	Phage regulatory protein
LC20_00475	COG3645	SOS response
LC20_00476	COG1403	HNH endonuclease
LC20_00482	COG3772	lysozyme
LC20_00500	COG4386	tail sheath protein
LC20_00525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LC20_00529	COG0305	Participates in initiation and elongation during chromosome replication
LC20_00530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LC20_00531	COG1448	Aminotransferase
LC20_00533	COG2315	Protein conserved in bacteria
LC20_00540	COG2252	PERMEase
LC20_00542	COG0025	NhaP-type Na H and K H
LC20_00543	COG0583	DNA-binding transcription factor activity
LC20_00544	COG1380	Effector of murein hydrolase LrgA
LC20_00548	COG1126	abc transporter atp-binding protein
LC20_00549	COG0765	amino acid transport
LC20_00550	COG4597	amino acid ABC transporter
LC20_00551	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_00553	COG1560	Kdo2-lipid A biosynthetic process
LC20_00554	COG0471	metal ion transport
LC20_00556	COG1278	Cold shock
LC20_00557	COG1278	Cold shock
LC20_00558	COG3133	Outer membrane lipoprotein
LC20_00559	COG3706	GGDEF domain
LC20_00560	COG0582	viral genome integration into host DNA
LC20_00577	COG1802	Transcriptional regulator
LC20_00577	COG4626	Terminase
LC20_00580	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LC20_00581	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LC20_00583	COG2264	protein methyltransferase activity
LC20_00584	COG4145	pantothenate transmembrane transporter activity
LC20_00585	COG3924	membrane
LC20_00586	COG0439	Biotin carboxylase
LC20_00587	COG0511	ligase activity, forming carbon-carbon bonds
LC20_00588	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LC20_00589	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LC20_00591	COG0604	alcohol dehydrogenase
LC20_00600	COG1792	Involved in formation and maintenance of cell shape
LC20_00601	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LC20_00603	COG1530	ribonuclease E activity
LC20_00606	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LC20_00607	COG0312	modulator of DNA gyrase
LC20_00608	COG0583	DNA-binding transcription factor activity
LC20_00610	COG1566	PFAM secretion protein HlyD family protein
LC20_00611	COG1289	transmembrane transporter activity
LC20_00614	COG2732	(Barnase) inhibitor
LC20_00615	COG3028	Belongs to the UPF0307 family
LC20_00616	COG0312	modulator of DNA gyrase
LC20_00617	COG3783	Cytochrome b(562)
LC20_00618	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LC20_00624	COG3964	amidohydrolase
LC20_00627	COG2706	6-phosphogluconolactonase activity
LC20_00628	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_00628	COG3711	transcriptional antiterminator
LC20_00629	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LC20_00630	COG1609	Transcriptional regulator
LC20_00631	COG1263	PTS System
LC20_00631	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_00632	COG0366	Alpha amylase catalytic
LC20_00636	COG2308	Evidence 4 Homologs of previously reported genes of
LC20_00639	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LC20_00640	COG0540	Belongs to the ATCase OTCase family
LC20_00642	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_00643	COG1660	Displays ATPase and GTPase activities
LC20_00644	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_00646	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LC20_00647	COG1137	ATPase activity
LC20_00648	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LC20_00649	COG3117	lipopolysaccharide transmembrane transporter activity
LC20_00650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LC20_00651	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LC20_00651	COG0517	IMP dehydrogenase activity
LC20_00652	COG0530	calcium, potassium:sodium antiporter activity
LC20_00653	COG1127	ABC transporter
LC20_00654	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LC20_00655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LC20_00656	COG2854	intermembrane phospholipid transfer
LC20_00657	COG3113	response to antibiotic
LC20_00658	COG5007	Belongs to the BolA IbaG family
LC20_00659	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LC20_00662	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LC20_00663	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LC20_00664	COG3105	Protein conserved in bacteria
LC20_00665	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LC20_00667	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LC20_00668	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LC20_00670	COG0625	glutathione transferase activity
LC20_00671	COG2969	positive regulation of protein catabolic process
LC20_00673	COG0493	'glutamate synthase
LC20_00674	COG0070	glutamate synthase
LC20_00674	COG0069	glutamate synthase activity
LC20_00674	COG0067	glutamate synthase
LC20_00675	COG1242	4 iron, 4 sulfur cluster binding
LC20_00676	COG0784	Response regulator, receiver
LC20_00676	COG2198	Histidine kinase
LC20_00676	COG5002	protein histidine kinase activity
LC20_00677	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LC20_00678	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LC20_00679	COG2823	Periplasmic or secreted lipoprotein
LC20_00680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LC20_00681	COG0792	nuclease activity
LC20_00683	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LC20_00697	COG0840	transmembrane signaling receptor activity
LC20_00699	COG2204	response regulator
LC20_00703	COG3133	Outer membrane lipoprotein
LC20_00704	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LC20_00705	COG0437	4 iron, 4 sulfur cluster binding
LC20_00706	COG5557	Pfam Polysulphide reductase, NrfD
LC20_00707	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LC20_00708	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LC20_00709	COG1773	rubredoxin
LC20_00710	COG0375	protein maturation
LC20_00711	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LC20_00712	COG0298	carbon dioxide binding
LC20_00713	COG0409	Hydrogenase expression formation protein
LC20_00715	COG0309	Hydrogenase expression formation protein (HypE)
LC20_00716	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LC20_00732	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_00733	COG2271	Major facilitator Superfamily
LC20_00734	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_00735	COG3433	isochorismatase activity
LC20_00735	COG1535	isochorismatase
LC20_00736	COG1021	2,3-dihydroxybenzoate-AMP ligase
LC20_00737	COG1169	isochorismate synthase
LC20_00738	COG4592	Periplasmic binding protein
LC20_00741	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_00742	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_00743	COG1120	ATPase activity
LC20_00744	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LC20_00749	COG4774	siderophore transport
LC20_00751	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_00753	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_00760	COG4964	Belongs to the GSP D family
LC20_00777	COG0848	biopolymer transport protein
LC20_00778	COG0811	peptide transport
LC20_00782	COG0586	Pfam SNARE associated Golgi protein
LC20_00784	COG2207	Transcriptional regulator
LC20_00785	COG1979	alcohol dehydrogenase
LC20_00786	COG0656	L-ascorbic acid biosynthetic process
LC20_00788	COG2132	Multicopper oxidase
LC20_00789	COG0204	Acyl-transferase
LC20_00791	COG2249	NAD(P)H dehydrogenase (quinone) activity
LC20_00792	COG0583	DNA-binding transcription factor activity
LC20_00793	COG0187	DNA topoisomerase II activity
LC20_00796	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LC20_00797	COG3151	Protein conserved in bacteria
LC20_00798	COG0494	nUDIX hydrolase
LC20_00800	COG1538	Outer membrane efflux protein
LC20_00802	COG0754	glutathionylspermidine amidase activity
LC20_00803	COG3384	dioxygenase
LC20_00804	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LC20_00806	COG0531	amino acid
LC20_00807	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LC20_00807	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LC20_00808	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LC20_00809	COG3025	triphosphatase activity
LC20_00810	COG4991	sh3 domain protein
LC20_00811	COG0617	tRNA 3'-terminal CCA addition
LC20_00812	COG1968	undecaprenyl-diphosphatase activity
LC20_00813	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LC20_00814	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LC20_00815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LC20_00817	COG0358	DNA primase activity
LC20_00819	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LC20_00852	COG3876	Protein conserved in bacteria
LC20_00855	COG1472	Belongs to the glycosyl hydrolase 3 family
LC20_00857	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LC20_00858	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_00858	COG1263	PTS System
LC20_00859	COG2066	Belongs to the glutaminase family
LC20_00860	COG0531	amino acid
LC20_00861	COG0076	glutamate decarboxylase activity
LC20_00863	COG2814	Major facilitator Superfamily
LC20_00864	COG3247	response to pH
LC20_00867	COG1902	pentaerythritol trinitrate reductase activity
LC20_00867	COG0446	pyridine nucleotide-disulphide oxidoreductase
LC20_00868	COG2813	Specifically methylates the guanine in position
LC20_00872	COG1451	nucleotide metabolic process
LC20_00873	COG0673	inositol 2-dehydrogenase activity
LC20_00874	COG0861	Integral membrane protein TerC family
LC20_00876	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LC20_00878	COG2721	sulfolactate sulfo-lyase activity
LC20_00879	COG0246	Mannitol dehydrogenase
LC20_00880	COG1904	glucuronate isomerase
LC20_00881	COG2271	Major facilitator Superfamily
LC20_00884	COG0586	Pfam SNARE associated Golgi protein
LC20_00888	COG4575	ribosome binding
LC20_00889	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LC20_00891	COG2259	Doxx family
LC20_00892	COG0435	Glutathione S-transferase
LC20_00893	COG0583	DNA-binding transcription factor activity
LC20_00894	COG1741	Belongs to the pirin family
LC20_00904	COG2885	chlorophyll binding
LC20_00941	COG0288	reversible hydration of carbon dioxide
LC20_00942	COG1733	regulation of RNA biosynthetic process
LC20_00943	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_00946	COG0484	heat shock protein binding
LC20_00947	COG1609	Transcriptional regulator
LC20_00949	COG2271	Major facilitator Superfamily
LC20_00952	COG1522	sequence-specific DNA binding
LC20_00960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LC20_00962	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LC20_00963	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LC20_00964	COG4974	Belongs to the 'phage' integrase family
LC20_00965	COG0716	FMN binding
LC20_00966	COG4452	Inner membrane protein CreD
LC20_00967	COG2205	protein histidine kinase activity
LC20_00968	COG0745	RESPONSE REGULATOR receiver
LC20_00970	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LC20_00971	COG0354	folic acid binding
LC20_00972	COG1272	protein, Hemolysin III
LC20_00974	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_00976	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LC20_00976	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LC20_00977	COG0509	glycine decarboxylation via glycine cleavage system
LC20_00978	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LC20_00981	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LC20_00982	COG0006	proline dipeptidase activity
LC20_00983	COG3079	Belongs to the UPF0149 family
LC20_00984	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LC20_00985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LC20_00986	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LC20_00988	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LC20_00989	COG0583	DNA-binding transcription factor activity
LC20_00991	COG1279	arginine transmembrane transporter activity
LC20_00993	COG0191	fructose-bisphosphate aldolase activity
LC20_00994	COG0126	phosphoglycerate kinase activity
LC20_00995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LC20_00997	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LC20_00998	COG0501	Belongs to the peptidase M48B family
LC20_01001	COG1166	arginine decarboxylase activity
LC20_01006	COG0640	Transcriptional regulator
LC20_01007	COG3091	SprT-like family
LC20_01008	COG2356	endonuclease I
LC20_01009	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LC20_01010	COG0189	ligase activity
LC20_01012	COG1678	Uncharacterized ACR, COG1678
LC20_01013	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LC20_01015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LC20_01017	COG2805	Type II/IV secretion system protein
LC20_01018	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LC20_01019	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LC20_01020	COG0762	integral membrane protein
LC20_01021	COG1872	DUF167
LC20_01022	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LC20_01023	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LC20_01025	COG2066	Belongs to the glutaminase family
LC20_01026	COG3171	Protein conserved in bacteria
LC20_01028	COG2814	Major facilitator Superfamily
LC20_01030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LC20_01031	COG1194	a g-specific adenine glycosylase
LC20_01033	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LC20_01034	COG0741	lytic transglycosylase activity
LC20_01036	COG1982	Orn Lys Arg decarboxylase major
LC20_01073	COG2165	general secretion pathway protein
LC20_01086	COG0583	DNA-binding transcription factor activity
LC20_01088	COG2814	Major facilitator Superfamily
LC20_01089	COG0583	DNA-binding transcription factor activity
LC20_01090	COG0019	diaminopimelate decarboxylase activity
LC20_01091	COG1609	Transcriptional regulator
LC20_01093	COG0204	Acyl-transferase
LC20_01093	COG0318	PFAM AMP-dependent synthetase and ligase
LC20_01094	COG0477	Major facilitator Superfamily
LC20_01095	COG0667	Aldo Keto reductase
LC20_01096	COG0861	Integral membrane protein TerC family
LC20_01097	COG3066	DNA modification
LC20_01099	COG1051	belongs to the nudix hydrolase family
LC20_01101	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LC20_01107	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LC20_01108	COG1025	Belongs to the peptidase M16 family
LC20_01111	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LC20_01112	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LC20_01112	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LC20_01113	COG0860	N-Acetylmuramoyl-L-alanine amidase
LC20_01118	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LC20_01119	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LC20_01120	COG2166	iron-sulfur cluster assembly
LC20_01121	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LC20_01123	COG0583	DNA-binding transcription factor activity
LC20_01124	COG2363	Small membrane protein
LC20_01125	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LC20_01126	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LC20_01129	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LC20_01129	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LC20_01133	COG3423	Transcriptional regulator
LC20_01149	COG4382	Mu-like prophage protein Gp16
LC20_01152	COG3179	chitinase
LC20_01162	COG4383	Mu-like prophage protein gp29
LC20_01167	COG4397	Mu-like prophage major head subunit gpT
LC20_01185	COG3098	single-species biofilm formation
LC20_01186	COG0564	pseudouridine synthase activity
LC20_01190	COG2171	N-acyltransferase activity
LC20_01191	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LC20_01192	COG0024	Methionine aminopeptidase
LC20_01194	COG0052	Belongs to the universal ribosomal protein uS2 family
LC20_01195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LC20_01196	COG0528	UMP kinase activity
LC20_01199	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LC20_01200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LC20_01201	COG0575	Belongs to the CDS family
LC20_01202	COG0750	zinc metalloprotease
LC20_01204	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LC20_01205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_01206	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LC20_01207	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_01208	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_01209	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LC20_01212	COG0825	malonyl-CoA metabolic process
LC20_01214	COG0346	lactoylglutathione lyase activity
LC20_01215	COG0037	tRNA processing
LC20_01218	COG4681	YaeQ
LC20_01220	COG3015	lipoprotein NlpE involved in copper resistance
LC20_01221	COG0442	prolyl-tRNA aminoacylation
LC20_01225	COG1464	Belongs to the NlpA lipoprotein family
LC20_01226	COG2011	ABC-type metal ion transport system permease component
LC20_01228	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LC20_01229	COG5544	Lipoprotein
LC20_01230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LC20_01231	COG1042	CoA-binding domain protein
LC20_01231	COG0045	succinate-CoA ligase (ADP-forming) activity
LC20_01231	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LC20_01233	COG3118	belongs to the thioredoxin family
LC20_01234	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LC20_01235	COG2814	Major facilitator Superfamily
LC20_01236	COG1566	PFAM secretion protein HlyD family protein
LC20_01237	COG1538	Outer membrane efflux protein
LC20_01238	COG1846	Transcriptional regulator
LC20_01240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LC20_01257	COG1126	abc transporter atp-binding protein
LC20_01258	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LC20_01261	COG0436	Aminotransferase
LC20_01262	COG0235	Class ii aldolase
LC20_01263	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LC20_01264	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LC20_01265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LC20_01266	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LC20_01272	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
LC20_01273	COG1960	acyl-CoA dehydrogenase activity
LC20_01275	COG0121	glutamine amidotransferase
LC20_01276	COG3034	peptidoglycan biosynthetic process
LC20_01277	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_01281	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_01282	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_01283	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LC20_01285	COG2871	sodium ion transport
LC20_01286	COG1477	protein flavinylation
LC20_01287	COG2991	Protein conserved in bacteria
LC20_01290	COG0584	glycerophosphoryl diester phosphodiesterase
LC20_01291	COG1181	Belongs to the D-alanine--D-alanine ligase family
LC20_01292	COG2964	Protein conserved in bacteria
LC20_01295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LC20_01296	COG2195	Cleaves the N-terminal amino acid of tripeptides
LC20_01298	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LC20_01302	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LC20_01303	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LC20_01304	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_01305	COG2313	pseudouridylate synthase activity
LC20_01306	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_01307	COG2188	Transcriptional regulator
LC20_01314	COG2226	methyltransferase
LC20_01317	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LC20_01319	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LC20_01322	COG3123	guanosine phosphorylase activity
LC20_01326	COG1940	carbohydrate kinase activity
LC20_01330	COG0745	RESPONSE REGULATOR receiver
LC20_01331	COG5002	protein histidine kinase activity
LC20_01333	COG1114	Component of the transport system for branched-chain amino acids
LC20_01336	COG0366	Alpha amylase catalytic
LC20_01341	COG0450	alkyl hydroperoxide reductase
LC20_01342	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LC20_01343	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LC20_01347	COG0343	queuine tRNA-ribosyltransferase activity
LC20_01348	COG1862	Preprotein translocase
LC20_01349	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LC20_01350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LC20_01352	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LC20_01353	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LC20_01353	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LC20_01354	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LC20_01355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LC20_01356	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LC20_01357	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LC20_01358	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LC20_01359	COG0142	geranyltranstransferase activity
LC20_01360	COG1722	exodeoxyribonuclease VII activity
LC20_01361	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LC20_01361	COG0301	tRNA thio-modification
LC20_01366	COG1840	ABC-type Fe3 transport system, periplasmic component
LC20_01370	COG0693	protein deglycase activity
LC20_01371	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LC20_01373	COG1666	GTP binding
LC20_01374	COG2814	Major facilitator Superfamily
LC20_01375	COG0109	protoheme IX farnesyltransferase activity
LC20_01376	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LC20_01377	COG1845	cytochrome c oxidase, subunit III
LC20_01378	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LC20_01379	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LC20_01381	COG2223	nitrite transmembrane transporter activity
LC20_01382	COG3056	Lipoprotein
LC20_01383	COG0271	Belongs to the BolA IbaG family
LC20_01385	COG0544	peptidyl-prolyl cis-trans isomerase activity
LC20_01388	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LC20_01390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LC20_01391	COG0776	regulation of translation
LC20_01393	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LC20_01394	COG1555	photosystem II stabilization
LC20_01400	COG0824	Thioesterase
LC20_01401	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LC20_01402	COG4533	DNA binding
LC20_01403	COG0561	phosphatase activity
LC20_01405	COG1522	sequence-specific DNA binding
LC20_01406	COG1132	(ABC) transporter
LC20_01407	COG1132	(ABC) transporter
LC20_01408	COG0347	Belongs to the P(II) protein family
LC20_01409	COG0004	ammonium transporteR
LC20_01410	COG1946	Acyl-CoA thioesterase
LC20_01412	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LC20_01413	COG3695	enzyme binding
LC20_01415	COG1388	LysM domain
LC20_01415	COG1470	cell adhesion involved in biofilm formation
LC20_01423	COG1121	(ABC) transporter
LC20_01424	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_01431	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LC20_01432	COG0254	rRNA binding
LC20_01434	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LC20_01435	COG3457	Alanine racemase
LC20_01437	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_01438	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_01439	COG1309	transcriptional regulator
LC20_01440	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LC20_01445	COG2832	Protein of unknown function (DUF454)
LC20_01446	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LC20_01448	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LC20_01450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LC20_01451	COG0326	Molecular chaperone. Has ATPase activity
LC20_01452	COG0563	adenylate kinase activity
LC20_01453	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LC20_01456	COG1442	glycosyl transferase family 8
LC20_01456	COG1216	Glycosyl transferase, family 2
LC20_01459	COG0438	transferase activity, transferring glycosyl groups
LC20_01460	COG0438	transferase activity, transferring glycosyl groups
LC20_01461	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LC20_01465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_01466	COG4651	solute:proton antiporter activity
LC20_01466	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LC20_01468	COG2223	nitrite transmembrane transporter activity
LC20_01470	COG0737	Belongs to the 5'-nucleotidase family
LC20_01474	COG3735	TraB family
LC20_01475	COG2217	Heavy metal translocating P-type atpase
LC20_01476	COG0789	Transcriptional regulator
LC20_01477	COG1585	Membrane protein implicated in regulation of membrane protease activity
LC20_01478	COG0330	HflC and HflK could
LC20_01479	COG3118	belongs to the thioredoxin family
LC20_01480	COG0300	oxidoreductase activity
LC20_01481	COG2755	lipolytic protein G-D-S-L family
LC20_01482	COG4181	ATPase activity
LC20_01483	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LC20_01485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LC20_01487	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LC20_01488	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LC20_01489	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LC20_01490	COG0215	cysteine-tRNA ligase activity
LC20_01492	COG2501	S4 domain
LC20_01493	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LC20_01494	COG0582	viral genome integration into host DNA
LC20_01531	COG4789	Type iii secretion
LC20_01533	COG1157	protein secretion by the type III secretion system
LC20_01564	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LC20_01584	COG2850	peptidyl-arginine hydroxylation
LC20_01585	COG5265	(ABC) transporter
LC20_01591	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LC20_01593	COG2197	response regulator
LC20_01594	COG1278	Cold shock
LC20_01595	COG1278	Cold shock
LC20_01597	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LC20_01598	COG3706	GGDEF domain
LC20_01599	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LC20_01600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LC20_01601	COG0321	lipoyl(octanoyl) transferase activity
LC20_01602	COG2921	Belongs to the UPF0250 family
LC20_01603	COG1686	Belongs to the peptidase S11 family
LC20_01604	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LC20_01605	COG0772	Belongs to the SEDS family
LC20_01606	COG0768	penicillin binding
LC20_01608	COG0799	negative regulation of ribosome biogenesis
LC20_01609	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LC20_01610	COG1466	dna polymerase III delta subunit
LC20_01611	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LC20_01612	COG0495	leucyl-tRNA aminoacylation
LC20_01614	COG2888	peptidyl-tyrosine sulfation
LC20_01616	COG1126	abc transporter atp-binding protein
LC20_01617	COG0765	amino acid transport
LC20_01619	COG0765	amino acid transport
LC20_01624	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LC20_01625	COG4535	Mg2 and Co2 transporter CorC
LC20_01626	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LC20_01627	COG1702	phosphate starvation-inducible protein PhoH
LC20_01628	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LC20_01629	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LC20_01632	COG0367	asparagine synthase
LC20_01633	COG0647	UMP catabolic process
LC20_01634	COG1846	Transcriptional regulator
LC20_01634	COG1940	carbohydrate kinase activity
LC20_01635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LC20_01636	COG0363	glucosamine-6-phosphate deaminase activity
LC20_01637	COG1263	PTS System
LC20_01637	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_01637	COG2190	(PTS) system
LC20_01638	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LC20_01643	COG0735	belongs to the Fur family
LC20_01646	COG0840	transmembrane signaling receptor activity
LC20_01649	COG0596	Alpha beta hydrolase
LC20_01650	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LC20_01651	COG0033	Phosphoglucomutase
LC20_01654	COG0745	RESPONSE REGULATOR receiver
LC20_01655	COG2205	protein histidine kinase activity
LC20_01656	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LC20_01658	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LC20_01659	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LC20_01663	COG3272	Protein of unknown function (DUF1722)
LC20_01666	COG5212	phosphodiesterase
LC20_01667	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LC20_01669	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LC20_01670	COG1984	allophanate hydrolase subunit 2
LC20_01671	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LC20_01674	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LC20_01678	COG2009	succinate dehydrogenase
LC20_01679	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LC20_01680	COG1053	succinate dehydrogenase
LC20_01682	COG0567	Dehydrogenase, E1 component
LC20_01683	COG0508	dehydrogenase complex catalyzes the overall conversion of
LC20_01685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LC20_01686	COG0737	Belongs to the 5'-nucleotidase family
LC20_01688	COG1271	oxidase subunit
LC20_01689	COG1294	oxidase, subunit
LC20_01690	COG4890	Cyd operon protein YbgT
LC20_01692	COG0824	Thioesterase
LC20_01693	COG0811	peptide transport
LC20_01694	COG0848	biopolymer transport protein
LC20_01695	COG3064	Membrane
LC20_01695	COG3064	Membrane
LC20_01696	COG0823	Involved in the tonB-independent uptake of proteins
LC20_01697	COG2885	chlorophyll binding
LC20_01698	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LC20_01699	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LC20_01701	COG1230	cation diffusion facilitator family transporter
LC20_01702	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LC20_01703	COG0588	phosphoglycerate mutase activity
LC20_01705	COG2017	converts alpha-aldose to the beta-anomer
LC20_01706	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LC20_01708	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LC20_01710	COG1119	ATPase activity
LC20_01711	COG3585	molybdate ion transport
LC20_01711	COG2005	Transcriptional regulator
LC20_01713	COG0725	ABC transporter, periplasmic molybdate-binding protein
LC20_01714	COG0582	viral genome integration into host DNA
LC20_01730	COG1484	DNA-dependent DNA replication
LC20_01731	COG0305	Participates in initiation and elongation during chromosome replication
LC20_01739	COG3179	chitinase
LC20_01757	COG4386	tail sheath protein
LC20_01771	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LC20_01775	COG4149	molybdate abc transporter
LC20_01777	COG0561	phosphatase activity
LC20_01781	COG2706	6-phosphogluconolactonase activity
LC20_01784	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LC20_01785	COG0156	8-amino-7-oxononanoate synthase activity
LC20_01786	COG2226	methyltransferase
LC20_01787	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LC20_01790	COG0556	nucleotide-excision repair
LC20_01791	COG4628	conserved protein (DUF2132)
LC20_01792	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LC20_01793	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LC20_01794	COG0315	cyclic pyranopterin monophosphate synthase activity
LC20_01795	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LC20_01796	COG0314	molybdopterin synthase activity
LC20_01797	COG0670	Belongs to the BI1 family
LC20_01798	COG0842	Transport permease protein
LC20_01799	COG0842	Transport permease protein
LC20_01800	COG1131	(ABC) transporter
LC20_01801	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_01802	COG1309	transcriptional regulator
LC20_01803	COG0513	Belongs to the DEAD box helicase family
LC20_01836	COG1686	Belongs to the peptidase S11 family
LC20_01837	COG0277	FAD linked oxidase domain protein
LC20_01841	COG2261	transglycosylase associated protein
LC20_01843	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LC20_01848	COG4807	Protein conserved in bacteria
LC20_01850	COG0559	Belongs to the binding-protein-dependent transport system permease family
LC20_01853	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LC20_01854	COG0410	ABC transporter
LC20_01855	COG2897	thiosulfate sulfurtransferase activity
LC20_01856	COG0673	inositol 2-dehydrogenase activity
LC20_01862	COG1174	glycine betaine transport
LC20_01863	COG1125	glycine betaine transport
LC20_01864	COG1174	glycine betaine transport
LC20_01868	COG0697	spore germination
LC20_01876	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LC20_01878	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LC20_01882	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LC20_01883	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LC20_01885	COG1126	abc transporter atp-binding protein
LC20_01886	COG0765	amino acid transport
LC20_01887	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_01889	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LC20_01890	COG0783	Belongs to the Dps family
LC20_01891	COG4106	trans-aconitate 2-methyltransferase activity
LC20_01894	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LC20_01898	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LC20_01903	COG0488	(ABC) transporter
LC20_01904	COG3397	chitin binding
LC20_01905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LC20_01906	COG0303	'Molybdopterin
LC20_01909	COG0477	Major facilitator Superfamily
LC20_01910	COG0577	efflux transmembrane transporter activity
LC20_01910	COG1136	(ABC) transporter
LC20_01917	COG0583	DNA-binding transcription factor activity
LC20_01919	COG0477	Major facilitator Superfamily
LC20_01920	COG0302	gtp cyclohydrolase
LC20_01922	COG2311	Membrane
LC20_01931	COG3383	formate dehydrogenase (NAD+) activity
LC20_01932	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_01933	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LC20_01935	COG3260	NADH ubiquinone oxidoreductase 20
LC20_01936	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_01937	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LC20_01937	COG3261	NADH dehydrogenase
LC20_01938	COG0651	ATP synthesis coupled electron transport
LC20_01939	COG4237	Hydrogenase 4 membrane
LC20_01940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LC20_01941	COG0650	Formate hydrogenlyase subunit 4
LC20_01942	COG0651	ATP synthesis coupled electron transport
LC20_01943	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_01945	COG0375	protein maturation
LC20_01946	COG0298	carbon dioxide binding
LC20_01948	COG2949	membrane
LC20_01950	COG0281	malic enzyme
LC20_01953	COG1346	cytolysis
LC20_01954	COG1380	Effector of murein hydrolase LrgA
LC20_01955	COG2814	Major facilitator Superfamily
LC20_01961	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LC20_01961	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LC20_01962	COG0489	protein tyrosine kinase activity
LC20_01965	COG2982	Protein involved in outer membrane biogenesis
LC20_01966	COG3069	C4-dicarboxylate transmembrane transporter activity
LC20_01970	COG1253	flavin adenine dinucleotide binding
LC20_01980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LC20_01985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LC20_01986	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LC20_01988	COG0140	phosphoribosyl-ATP diphosphatase activity
LC20_01988	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LC20_01989	COG0107	imidazoleglycerol-phosphate synthase activity
LC20_01990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LC20_01991	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LC20_01992	COG0131	Imidazoleglycerol-phosphate dehydratase
LC20_01992	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LC20_01993	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LC20_01995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LC20_01996	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_01997	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_02001	COG0371	Dehydrogenase
LC20_02002	COG0531	amino acid
LC20_02003	COG2925	Exonuclease
LC20_02004	COG1022	Amp-dependent synthetase and ligase
LC20_02004	COG3320	Male sterility
LC20_02010	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_02012	COG1879	ABC-type sugar transport system periplasmic component
LC20_02015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LC20_02020	COG4810	utilization protein
LC20_02022	COG4656	Part of a membrane complex involved in electron transport
LC20_02028	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
LC20_02034	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LC20_02036	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
LC20_02037	COG2241	protein methyltransferase activity
LC20_02039	COG2875	Belongs to the precorrin methyltransferase family
LC20_02050	COG1492	cobalamin metabolic process
LC20_02055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LC20_02056	COG0137	argininosuccinate synthase activity
LC20_02057	COG0534	Mate efflux family protein
LC20_02058	COG0835	chemotaxis
LC20_02058	COG0784	Response regulator, receiver
LC20_02059	COG3842	ATPase activity
LC20_02062	COG1840	ABC-type Fe3 transport system, periplasmic component
LC20_02063	COG2271	Major facilitator Superfamily
LC20_02066	COG4565	transcriptional regulatory protein
LC20_02067	COG3290	protein histidine kinase activity
LC20_02069	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LC20_02070	COG3052	prosthetic group binding
LC20_02071	COG2301	Belongs to the HpcH HpaI aldolase family
LC20_02072	COG3051	citrate lyase alpha subunit
LC20_02073	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LC20_02073	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
LC20_02075	COG0471	metal ion transport
LC20_02078	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LC20_02096	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_02096	COG2205	protein histidine kinase activity
LC20_02101	COG3228	Belongs to the MtfA family
LC20_02104	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LC20_02105	COG4589	Belongs to the CDS family
LC20_02107	COG2267	carboxylic ester hydrolase activity
LC20_02109	COG2453	phosphatase
LC20_02109	COG0671	phosphoesterase, PA-phosphatase related
LC20_02111	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LC20_02116	COG1522	sequence-specific DNA binding
LC20_02119	COG0604	alcohol dehydrogenase
LC20_02119	COG3321	synthase
LC20_02119	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_02120	COG3250	beta-galactosidase activity
LC20_02122	COG1609	Transcriptional regulator
LC20_02125	COG0840	transmembrane signaling receptor activity
LC20_02128	COG1285	pathogenesis
LC20_02131	COG0589	response to stress
LC20_02135	COG1360	Flagellar Motor Protein
LC20_02136	COG2198	Histidine kinase
LC20_02136	COG0643	Histidine kinase
LC20_02137	COG0835	chemotaxis
LC20_02139	COG0840	transmembrane signaling receptor activity
LC20_02140	COG0840	transmembrane signaling receptor activity
LC20_02141	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LC20_02144	COG0745	RESPONSE REGULATOR receiver
LC20_02145	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LC20_02146	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LC20_02147	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LC20_02152	COG3418	PFAM FlgN family protein
LC20_02153	COG2747	anti-sigma28 factor FlgM
LC20_02156	COG1815	bacterial-type flagellum-dependent cell motility
LC20_02157	COG1558	bacterial-type flagellum-dependent cell motility
LC20_02158	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LC20_02159	COG1749	Flagellar hook protein flgE
LC20_02162	COG4786	Flagellar basal body rod
LC20_02166	COG1256	bacterial-type flagellum assembly
LC20_02167	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LC20_02170	COG1338	Plays a role in the flagellum-specific transport system
LC20_02174	COG1580	Controls the rotational direction of flagella during chemotaxis
LC20_02177	COG2882	bacterial-type flagellum organization
LC20_02178	COG1157	protein secretion by the type III secretion system
LC20_02179	COG1317	bacterial-type flagellum organization
LC20_02180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LC20_02183	COG1677	Flagellar hook-basal body complex protein FliE
LC20_02188	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LC20_02197	COG1191	sigma factor activity
LC20_02201	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LC20_02208	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LC20_02208	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LC20_02208	COG0506	proline dehydrogenase activity
LC20_02221	COG1881	PFAM PEBP family protein
LC20_02223	COG1113	amino acid transport
LC20_02227	COG2226	methyltransferase
LC20_02230	COG0366	Alpha amylase catalytic
LC20_02235	COG2197	response regulator
LC20_02237	COG0322	excinuclease ABC activity
LC20_02238	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LC20_02254	COG0305	Participates in initiation and elongation during chromosome replication
LC20_02263	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LC20_02266	COG3772	lysozyme
LC20_02290	COG0456	acetyltransferase
LC20_02296	COG0561	phosphatase activity
LC20_02297	COG2223	nitrite transmembrane transporter activity
LC20_02299	COG0346	lactoylglutathione lyase activity
LC20_02304	COG3493	citrate carrier protein
LC20_02305	COG4565	transcriptional regulatory protein
LC20_02306	COG3290	protein histidine kinase activity
LC20_02307	COG1349	DNA-binding transcription factor activity
LC20_02308	COG3395	kinase activity
LC20_02309	COG0235	Class ii aldolase
LC20_02310	COG3622	Belongs to the hyi family
LC20_02311	COG2066	Belongs to the glutaminase family
LC20_02315	COG0672	)-iron permease
LC20_02324	COG0006	proline dipeptidase activity
LC20_02325	COG0457	Tetratricopeptide repeat
LC20_02327	COG0726	polysaccharide deacetylase
LC20_02327	COG1649	PFAM Uncharacterised BCR, COG1649
LC20_02328	COG1215	transferase activity, transferring glycosyl groups
LC20_02329	COG3658	cytochrome
LC20_02332	COG1702	phosphate starvation-inducible protein PhoH
LC20_02333	COG0387	Pfam Sodium calcium exchanger
LC20_02336	COG0583	DNA-binding transcription factor activity
LC20_02337	COG3850	Histidine kinase
LC20_02340	COG1294	oxidase, subunit
LC20_02341	COG1271	oxidase subunit
LC20_02343	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_02349	COG3724	N-succinylarginine dihydrolase activity
LC20_02350	COG2988	succinylglutamate desuccinylase activity
LC20_02354	COG1228	amidohydrolase
LC20_02358	COG0402	S-adenosylhomocysteine deaminase activity
LC20_02364	COG4211	Belongs to the binding-protein-dependent transport system permease family
LC20_02365	COG3443	Belongs to the bacterial solute-binding protein 9 family
LC20_02367	COG4942	peptidase
LC20_02370	COG0191	fructose-bisphosphate aldolase activity
LC20_02371	COG2222	sugar isomerase
LC20_02374	COG3716	PTS system mannose fructose sorbose family IID component
LC20_02376	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_02379	COG1349	DNA-binding transcription factor activity
LC20_02386	COG0012	GTP binding
LC20_02388	COG0193	aminoacyl-tRNA hydrolase activity
LC20_02392	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LC20_02394	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LC20_02395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LC20_02396	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LC20_02397	COG2890	protein-(glutamine-N5) methyltransferase activity
LC20_02398	COG3094	Invasion gene expression up-regulator, SirB
LC20_02399	COG2912	Transglutaminase-like superfamily
LC20_02400	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LC20_02401	COG0659	secondary active sulfate transmembrane transporter activity
LC20_02404	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LC20_02405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LC20_02406	COG3381	protein complex oligomerization
LC20_02409	COG0477	Major facilitator Superfamily
LC20_02413	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LC20_02416	COG0673	inositol 2-dehydrogenase activity
LC20_02421	COG0728	peptidoglycan biosynthetic process
LC20_02422	COG0018	arginyl-trna synthetase
LC20_02425	COG3102	Protein conserved in bacteria
LC20_02431	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_02433	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LC20_02434	COG1801	Protein of unknown function DUF72
LC20_02435	COG1335	isochorismatase
LC20_02439	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LC20_02441	COG0494	nUDIX hydrolase
LC20_02442	COG0217	transcriptional regulatory protein
LC20_02446	COG2255	four-way junction helicase activity
LC20_02447	COG3104	oligopeptide transport
LC20_02448	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_02449	COG1121	(ABC) transporter
LC20_02452	COG0739	heme binding
LC20_02453	COG1560	Kdo2-lipid A biosynthetic process
LC20_02454	COG0469	pyruvate kinase activity
LC20_02455	COG1737	Transcriptional regulator
LC20_02456	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LC20_02458	COG0800	Aldolase
LC20_02460	COG2076	Multidrug Resistance protein
LC20_02461	COG2076	Multidrug Resistance protein
LC20_02462	COG0251	oxidation-reduction process
LC20_02463	COG1199	ATP-dependent helicase activity
LC20_02470	COG0318	PFAM AMP-dependent synthetase and ligase
LC20_02471	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LC20_02476	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LC20_02478	COG2894	cell division
LC20_02479	COG0850	regulation of cytokinetic process
LC20_02484	COG2951	lytic endotransglycosylase activity
LC20_02485	COG0179	Fumarylacetoacetate (FAA) hydrolase
LC20_02486	COG2983	Belongs to the UPF0260 family
LC20_02493	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LC20_02497	COG2186	Transcriptional regulator
LC20_02498	COG2719	SpoVR family
LC20_02500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LC20_02502	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LC20_02503	COG2814	Major facilitator Superfamily
LC20_02504	COG2200	EAL domain
LC20_02504	COG2199	diguanylate cyclase activity
LC20_02504	COG2202	Pas domain
LC20_02508	COG0583	DNA-binding transcription factor activity
LC20_02512	COG2766	serine protein kinase
LC20_02514	COG3713	MltA-interacting MipA family protein
LC20_02520	COG3139	Protein of unknown function (DUF1315)
LC20_02523	COG0252	asparaginase activity
LC20_02524	COG0616	signal peptide processing
LC20_02525	COG0778	Nitroreductase
LC20_02528	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LC20_02530	COG0494	nUDIX hydrolase
LC20_02533	COG0583	DNA-binding transcription factor activity
LC20_02534	COG0788	formyltetrahydrofolate deformylase activity
LC20_02535	COG3012	SEC-C Motif Domain Protein
LC20_02536	COG1752	Esterase of the alpha-beta hydrolase superfamily
LC20_02537	COG0745	RESPONSE REGULATOR receiver
LC20_02539	COG2916	Histone family protein nucleoid-structuring protein H-NS
LC20_02540	COG1435	thymidine kinase activity
LC20_02542	COG1454	alcohol dehydrogenase
LC20_02542	COG1012	belongs to the aldehyde dehydrogenase family
LC20_02545	COG2095	MarC family integral membrane protein
LC20_02553	COG0444	Belongs to the ABC transporter superfamily
LC20_02554	COG4608	Belongs to the ABC transporter superfamily
LC20_02556	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LC20_02562	COG2350	Protein conserved in bacteria
LC20_02563	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LC20_02564	COG1607	acyl-coa hydrolase
LC20_02565	COG2917	probably involved in intracellular septation
LC20_02569	COG3047	cAMP biosynthetic process
LC20_02571	COG0159	tryptophan synthase activity
LC20_02572	COG0133	tryptophan synthase activity
LC20_02573	COG0135	phosphoribosylanthranilate isomerase activity
LC20_02573	COG0134	indole-3-glycerol-phosphate synthase activity
LC20_02575	COG0512	Glutamine amidotransferase of anthranilate synthase
LC20_02579	COG0613	PHP domain protein
LC20_02580	COG0009	L-threonylcarbamoyladenylate synthase
LC20_02588	COG2373	Large extracellular alpha-helical protein
LC20_02588	COG1388	LysM domain
LC20_02588	COG4932	domain protein
LC20_02602	COG1187	pseudouridine synthase activity
LC20_02603	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LC20_02604	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_02605	COG0616	signal peptide processing
LC20_02607	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LC20_02609	COG0583	DNA-binding transcription factor activity
LC20_02621	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LC20_02624	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LC20_02625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LC20_02629	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LC20_02631	COG0673	inositol 2-dehydrogenase activity
LC20_02632	COG2072	flavoprotein involved in K transport
LC20_02636	COG1396	sequence-specific DNA binding
LC20_02637	COG3135	benzoate transporter
LC20_02641	COG0023	Translation Initiation Factor
LC20_02645	COG0235	Class ii aldolase
LC20_02647	COG1349	DNA-binding transcription factor activity
LC20_02649	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LC20_02650	COG2879	small protein
LC20_02651	COG1966	Carbon starvation protein
LC20_02657	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LC20_02659	COG4659	FMN binding
LC20_02660	COG4658	electron transport chain
LC20_02661	COG3708	Transcriptional regulator
LC20_02661	COG2207	Transcriptional regulator
LC20_02662	COG4656	Part of a membrane complex involved in electron transport
LC20_02664	COG4657	Part of a membrane complex involved in electron transport
LC20_02667	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LC20_02672	COG2274	protein secretion by the type I secretion system
LC20_02675	COG2160	L-arabinose isomerase activity
LC20_02678	COG1879	ABC-type sugar transport system periplasmic component
LC20_02680	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_02682	COG0673	inositol 2-dehydrogenase activity
LC20_02684	COG0385	Bile acid
LC20_02685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LC20_02686	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LC20_02687	COG1263	PTS System
LC20_02687	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_02688	COG1609	Transcriptional regulator
LC20_02690	COG5339	Protein conserved in bacteria
LC20_02692	COG0114	fumarate hydratase activity
LC20_02693	COG2020	methyltransferase activity
LC20_02699	COG3121	Chaperone
LC20_02700	COG3121	Chaperone
LC20_02702	COG3539	Fimbrial protein
LC20_02703	COG3121	Chaperone
LC20_02710	COG2814	Major facilitator Superfamily
LC20_02712	COG0583	DNA-binding transcription factor activity
LC20_02713	COG1940	carbohydrate kinase activity
LC20_02714	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LC20_02719	COG1742	UPF0060 membrane protein
LC20_02720	COG4221	oxidoreductase activity
LC20_02721	COG0477	Major facilitator Superfamily
LC20_02729	COG0625	glutathione transferase activity
LC20_02731	COG1522	sequence-specific DNA binding
LC20_02733	COG4215	(ABC) transporter
LC20_02740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LC20_02753	COG3710	Transcriptional regulator
LC20_02757	COG2831	hemolysin activation secretion protein
LC20_02761	COG3121	Chaperone
LC20_02767	COG0028	Belongs to the TPP enzyme family
LC20_02768	COG0440	acetolactate synthase activity
LC20_02770	COG1011	Hydrolase
LC20_02772	COG0583	DNA-binding transcription factor activity
LC20_02777	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_02779	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_02781	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LC20_02784	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LC20_02785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LC20_02786	COG0589	response to stress
LC20_02787	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LC20_02797	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LC20_02800	COG0531	amino acid
LC20_02802	COG0745	RESPONSE REGULATOR receiver
LC20_02803	COG2205	protein histidine kinase activity
LC20_02804	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LC20_02807	COG3591	Belongs to the peptidase S1B family
LC20_02810	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LC20_02816	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LC20_02817	COG2390	Transcriptional regulator
LC20_02818	COG0246	Mannitol dehydrogenase
LC20_02819	COG1070	Carbohydrate kinase
LC20_02824	COG3784	Protein of unknown function (DUF1318)
LC20_02826	COG2911	Protein conserved in bacteria
LC20_02828	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LC20_02829	COG3042	response to heat
LC20_02830	COG1285	pathogenesis
LC20_02837	COG0037	tRNA processing
LC20_02842	COG4166	transmembrane transport
LC20_02843	COG2866	Carboxypeptidase
LC20_02844	COG4948	Mandelate Racemase Muconate Lactonizing
LC20_02845	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LC20_02849	COG3768	UPF0283 membrane protein
LC20_02851	COG3106	COG3106 Predicted ATPase
LC20_02853	COG1983	PspC domain protein
LC20_02855	COG1842	Phage shock protein A
LC20_02856	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LC20_02860	COG4168	peptide transport system, permease
LC20_02861	COG4171	peptide transport system, permease
LC20_02863	COG4172	Belongs to the ABC transporter superfamily
LC20_02880	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LC20_02880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LC20_02889	COG0625	glutathione transferase activity
LC20_02891	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LC20_02892	COG0259	pyridoxamine-phosphate oxidase activity
LC20_02893	COG3895	Periplasmic Protein
LC20_02894	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LC20_02897	COG3133	Outer membrane lipoprotein
LC20_02898	COG1846	Transcriptional regulator
LC20_02900	COG1566	PFAM secretion protein HlyD family protein
LC20_02902	COG4989	oxidoreductase activity
LC20_02904	COG3313	Fe-S protein
LC20_02905	COG2194	sulfuric ester hydrolase activity
LC20_02906	COG1309	transcriptional regulator
LC20_02907	COG1902	pentaerythritol trinitrate reductase activity
LC20_02908	COG0346	lactoylglutathione lyase activity
LC20_02909	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LC20_02910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LC20_02911	COG0791	NLP P60 protein
LC20_02914	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LC20_02917	COG0583	DNA-binding transcription factor activity
LC20_02921	COG2814	Major facilitator Superfamily
LC20_02922	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LC20_02923	COG0307	riboflavin synthase, alpha
LC20_02924	COG0534	Mate efflux family protein
LC20_02926	COG4238	major outer membrane lipoprotein
LC20_02927	COG1388	LysM domain
LC20_02927	COG1376	ErfK ybiS ycfS ynhG family protein
LC20_02929	COG2166	iron-sulfur cluster assembly
LC20_02931	COG0719	Fe-S assembly protein
LC20_02932	COG0396	ATPase activity
LC20_02933	COG0719	Fe-S assembly protein
LC20_02934	COG0316	Belongs to the HesB IscA family
LC20_02935	COG2050	protein possibly involved in aromatic compounds catabolism
LC20_02936	COG0247	lactate metabolic process
LC20_02936	COG0277	FAD linked oxidase domain protein
LC20_02938	COG0628	permease
LC20_02942	COG0574	Belongs to the PEP-utilizing enzyme family
LC20_02942	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LC20_02943	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LC20_02948	COG4771	TonB-dependent receptor
LC20_02949	COG3720	iron ion transport
LC20_02953	COG0095	Lipoate-protein ligase
LC20_02954	COG0791	NLP P60 protein
LC20_02955	COG2076	Multidrug Resistance protein
LC20_02956	COG2076	Multidrug Resistance protein
LC20_02957	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LC20_02958	COG0726	polysaccharide deacetylase
LC20_02960	COG0463	Glycosyl transferase, family 2
LC20_02965	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LC20_02966	COG0386	Belongs to the glutathione peroxidase family
LC20_02969	COG2314	TM2 domain
LC20_02971	COG0776	regulation of translation
LC20_02975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LC20_02977	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LC20_02979	COG4249	Peptidase C14 caspase catalytic subunit p20
LC20_02988	COG0803	Belongs to the bacterial solute-binding protein 9 family
LC20_02991	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_02992	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LC20_02995	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LC20_02995	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LC20_02996	COG1703	isobutyryl-CoA mutase activity
LC20_02997	COG1024	Enoyl-CoA hydratase
LC20_02998	COG0427	acetyl-CoA hydrolase
LC20_02999	COG0583	DNA-binding transcription factor activity
LC20_03002	COG1917	Cupin 2, conserved barrel domain protein
LC20_03004	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LC20_03005	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_03008	COG1175	transmembrane transport
LC20_03009	COG0395	ABC-type sugar transport system, permease component
LC20_03010	COG3842	ATPase activity
LC20_03013	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LC20_03014	COG1988	membrane-bound metal-dependent
LC20_03016	COG3023	N-Acetylmuramoyl-L-alanine amidase
LC20_03019	COG0823	Involved in the tonB-independent uptake of proteins
LC20_03020	COG2814	Major facilitator Superfamily
LC20_03021	COG0501	Belongs to the peptidase M48B family
LC20_03028	COG1956	GAF domain-containing protein
LC20_03031	COG3008	intermembrane lipid transfer
LC20_03044	COG3706	GGDEF domain
LC20_03044	COG5001	Diguanylate cyclase
LC20_03044	COG4251	negative regulation of phosphorylation
LC20_03044	COG2203	Gaf domain
LC20_03050	COG0625	glutathione transferase activity
LC20_03054	COG0786	glutamate:sodium symporter activity
LC20_03055	COG1187	pseudouridine synthase activity
LC20_03060	COG3328	transposase activity
LC20_03087	COG3566	protein conserved in bacteria
LC20_03089	COG3567	Phage-associated protein, HI1409 family
LC20_03091	COG3077	Addiction module antitoxin, RelB DinJ family
LC20_03092	COG2026	Addiction module toxin, RelE StbE family
LC20_03097	COG1475	DNA binding
LC20_03102	COG3772	lysozyme
LC20_03119	COG1396	sequence-specific DNA binding
LC20_03127	COG0582	viral genome integration into host DNA
LC20_03128	COG3328	transposase activity
LC20_03131	COG1276	copper resistance
LC20_03132	COG2372	response to copper ion
LC20_03133	COG1528	Iron-storage protein
LC20_03138	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LC20_03139	COG1770	oligopeptidase
LC20_03142	COG3141	response to X-ray
LC20_03143	COG0513	Belongs to the DEAD box helicase family
LC20_03145	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LC20_03146	COG3140	Belongs to the UPF0181 family
LC20_03148	COG0494	nUDIX hydrolase
LC20_03150	COG1760	l-serine dehydratase
LC20_03154	COG1253	flavin adenine dinucleotide binding
LC20_03156	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_03156	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_03157	COG3715	PTS system
LC20_03158	COG3716	PTS system mannose fructose sorbose family IID component
LC20_03159	COG4811	Protein of unknown function (DUF986)
LC20_03160	COG1971	Probably functions as a manganese efflux pump
LC20_03164	COG5001	Diguanylate cyclase
LC20_03164	COG3447	MASE1 domain protein
LC20_03164	COG5002	protein histidine kinase activity
LC20_03166	COG2226	methyltransferase
LC20_03167	COG0768	penicillin binding
LC20_03172	COG1113	amino acid transport
LC20_03180	COG2207	Transcriptional regulator
LC20_03185	COG1132	(ABC) transporter
LC20_03187	COG5001	Diguanylate cyclase
LC20_03187	COG4251	negative regulation of phosphorylation
LC20_03187	COG2203	Gaf domain
LC20_03187	COG3706	GGDEF domain
LC20_03190	COG3755	Protein conserved in bacteria
LC20_03193	COG0697	spore germination
LC20_03194	COG2271	Major facilitator Superfamily
LC20_03195	COG4948	Mandelate Racemase Muconate Lactonizing
LC20_03196	COG1802	Transcriptional regulator
LC20_03197	COG1063	alcohol dehydrogenase
LC20_03198	COG0246	Mannitol dehydrogenase
LC20_03199	COG2721	sulfolactate sulfo-lyase activity
LC20_03202	COG1733	regulation of RNA biosynthetic process
LC20_03203	COG0702	epimerase
LC20_03204	COG2873	o-acetylhomoserine
LC20_03210	COG0840	transmembrane signaling receptor activity
LC20_03219	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_03219	COG2755	lipolytic protein G-D-S-L family
LC20_03220	COG3039	Transposase
LC20_03221	COG2755	lipolytic protein G-D-S-L family
LC20_03221	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_03233	COG2373	Large extracellular alpha-helical protein
LC20_03233	COG4932	domain protein
LC20_03233	COG1388	LysM domain
LC20_03261	COG3566	protein conserved in bacteria
LC20_03263	COG3567	Phage-associated protein, HI1409 family
LC20_03265	COG3077	Addiction module antitoxin, RelB DinJ family
LC20_03266	COG2026	Addiction module toxin, RelE StbE family
LC20_03271	COG1475	DNA binding
LC20_03274	COG3772	lysozyme
LC20_03304	COG0582	viral genome integration into host DNA
LC20_03306	COG0538	isocitrate dehydrogenase activity
LC20_03307	COG1187	pseudouridine synthase activity
LC20_03309	COG0482	sulfurtransferase activity
LC20_03310	COG2915	High frequency lysogenization protein hflD homolog
LC20_03311	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LC20_03313	COG0745	RESPONSE REGULATOR receiver
LC20_03315	COG2850	peptidyl-arginine hydroxylation
LC20_03317	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LC20_03319	COG1940	carbohydrate kinase activity
LC20_03320	COG4591	ABC-type transport system involved in lipoprotein release permease component
LC20_03322	COG4591	ABC-type transport system involved in lipoprotein release permease component
LC20_03323	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LC20_03324	COG3134	Outer membrane lipoprotein
LC20_03326	COG1252	NADH dehydrogenase
LC20_03327	COG3150	esterase
LC20_03328	COG1472	Belongs to the glycosyl hydrolase 3 family
LC20_03329	COG0510	thiamine kinase activity
LC20_03330	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LC20_03331	COG5633	Lipoprotein
LC20_03332	COG0537	adenosine 5'-monophosphoramidase activity
LC20_03333	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LC20_03336	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_03336	COG1263	PTS System
LC20_03339	COG0084	hydrolase, TatD family'
LC20_03340	COG0470	DNA polymerase III
LC20_03341	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LC20_03342	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LC20_03343	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LC20_03344	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LC20_03346	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_03347	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LC20_03349	COG0416	fatty acid biosynthetic process
LC20_03350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LC20_03351	COG1399	metal-binding, possibly nucleic acid-binding protein
LC20_03353	COG0564	pseudouridine synthase activity
LC20_03356	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LC20_03357	COG0418	dihydroorotase activity
LC20_03365	COG0628	permease
LC20_03373	COG1560	Kdo2-lipid A biosynthetic process
LC20_03374	COG2259	Doxx family
LC20_03375	COG2814	Major facilitator Superfamily
LC20_03376	COG3104	oligopeptide transport
LC20_03378	COG5645	(Lipo)protein
LC20_03379	COG2943	transferase activity, transferring hexosyl groups
LC20_03380	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LC20_03384	COG3263	regulation of cellular component size
LC20_03387	COG3916	Acyl-homoserine-lactone synthase
LC20_03388	COG2771	luxR family
LC20_03391	COG2920	part of a sulfur-relay system
LC20_03392	COG1254	Belongs to the acylphosphatase family
LC20_03395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LC20_03396	COG3785	DNA binding
LC20_03397	COG1832	CoA-binding protein
LC20_03401	COG1803	Methylglyoxal synthase
LC20_03403	COG0210	DNA helicase
LC20_03404	COG3304	Inner membrane component domain
LC20_03406	COG1289	transmembrane transporter activity
LC20_03407	COG3070	regulator of competence-specific genes
LC20_03408	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
LC20_03409	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LC20_03409	COG2885	chlorophyll binding
LC20_03410	COG3120	sequence-specific DNA binding
LC20_03411	COG1067	ATP-dependent peptidase activity
LC20_03412	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LC20_03414	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LC20_03415	COG3009	Protein conserved in bacteria
LC20_03416	COG3008	intermembrane lipid transfer
LC20_03416	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LC20_03417	COG2995	paraquat-inducible protein a
LC20_03418	COG0488	(ABC) transporter
LC20_03419	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LC20_03419	COG0116	Belongs to the methyltransferase superfamily
LC20_03420	COG0633	Ferredoxin
LC20_03420	COG3217	Mosc domain protein beta barrel domain protein
LC20_03422	COG0167	dihydroorotate dehydrogenase activity
LC20_03423	COG0308	aminopeptidase N
LC20_03432	COG1388	LysM domain
LC20_03432	COG2373	Large extracellular alpha-helical protein
LC20_03432	COG4932	domain protein
LC20_03435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_03440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_03449	COG0017	Asparaginyl-tRNA synthetase
LC20_03451	COG1448	Aminotransferase
LC20_03452	COG2200	EAL domain
LC20_03453	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LC20_03454	COG3108	Peptidase M15
LC20_03455	COG2989	Protein conserved in bacteria
LC20_03456	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LC20_03457	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LC20_03458	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LC20_03459	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_03460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LC20_03461	COG3173	Aminoglycoside phosphotransferase
LC20_03462	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LC20_03463	COG2835	tetraacyldisaccharide 4'-kinase activity
LC20_03465	COG1278	Cold shock
LC20_03466	COG1278	Cold shock
LC20_03467	COG5383	Protein conserved in bacteria
LC20_03469	COG1663	tetraacyldisaccharide 4'-kinase activity
LC20_03471	COG2333	competence protein COMEC
LC20_03471	COG0658	competence protein
LC20_03473	COG0776	regulation of translation
LC20_03474	COG0539	negative regulation of cytoplasmic translation
LC20_03475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LC20_03476	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LC20_03479	COG0252	asparaginase activity
LC20_03480	COG1944	ATP diphosphatase activity
LC20_03483	COG2116	formate transmembrane transporter activity
LC20_03484	COG1882	Formate acetyltransferase
LC20_03485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LC20_03486	COG2814	Major facilitator Superfamily
LC20_03488	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LC20_03491	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LC20_03492	COG3107	peptidoglycan biosynthetic process
LC20_03492	COG1674	ftsk spoiiie
LC20_03494	COG0492	ferredoxin-NADP+ reductase activity
LC20_03497	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LC20_03498	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LC20_03499	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LC20_03501	COG0542	response to heat
LC20_03502	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LC20_03503	COG1278	Cold shock
LC20_03505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_03506	COG2990	Protein conserved in bacteria
LC20_03507	COG3593	DNA synthesis involved in DNA repair
LC20_03509	COG2431	L-lysine efflux transmembrane transporter activity
LC20_03510	COG1151	hydroxylamine reductase activity
LC20_03511	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LC20_03512	COG0028	Belongs to the TPP enzyme family
LC20_03520	COG0702	epimerase
LC20_03521	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_03525	COG1126	abc transporter atp-binding protein
LC20_03526	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_03527	COG4215	(ABC) transporter
LC20_03528	COG4160	amino acid transport
LC20_03531	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_03532	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LC20_03535	COG1177	transmembrane transport
LC20_03536	COG1176	ABC-type spermidine putrescine transport system, permease component I
LC20_03537	COG3842	ATPase activity
LC20_03539	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LC20_03542	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_03543	COG0569	domain protein
LC20_03543	COG2985	domain, Protein
LC20_03545	COG0671	phosphoesterase, PA-phosphatase related
LC20_03546	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LC20_03548	COG1349	DNA-binding transcription factor activity
LC20_03552	COG0814	amino acid
LC20_03553	COG1760	l-serine dehydratase
LC20_03555	COG1686	Belongs to the peptidase S11 family
LC20_03557	COG0626	cystathionine gamma-synthase activity
LC20_03558	COG2011	ABC-type metal ion transport system permease component
LC20_03566	COG0625	glutathione transferase activity
LC20_03567	COG4771	TonB-dependent receptor
LC20_03569	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_03570	COG0833	amino acid
LC20_03572	COG0583	DNA-binding transcription factor activity
LC20_03575	COG2855	membrane
LC20_03577	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LC20_03579	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LC20_03579	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LC20_03579	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LC20_03580	COG1105	Belongs to the carbohydrate kinase PfkB family
LC20_03587	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LC20_03588	COG1312	Catalyzes the dehydration of D-mannonate
LC20_03589	COG0246	Mannitol dehydrogenase
LC20_03590	COG2186	Transcriptional regulator
LC20_03592	COG0523	cobalamin synthesis protein
LC20_03593	COG0671	phosphoesterase, PA-phosphatase related
LC20_03595	COG0791	NLP P60 protein
LC20_03596	COG2200	EAL domain
LC20_03597	COG4166	transmembrane transport
LC20_03599	COG4174	ABC transporter (Permease)
LC20_03603	COG4172	Belongs to the ABC transporter superfamily
LC20_03608	COG2814	Major facilitator Superfamily
LC20_03609	COG1187	pseudouridine synthase activity
LC20_03611	COG1061	Type III restriction enzyme res subunit
LC20_03614	COG3081	Nucleoid-associated protein
LC20_03615	COG3082	Protein of unknown function (DUF1414)
LC20_03622	COG2723	6-phospho-beta-galactosidase activity
LC20_03623	COG1263	PTS System
LC20_03623	COG2190	(PTS) system
LC20_03623	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_03630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LC20_03631	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LC20_03634	COG2223	nitrite transmembrane transporter activity
LC20_03635	COG2198	Histidine kinase
LC20_03635	COG0642	Histidine kinase
LC20_03650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_03651	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LC20_03653	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LC20_03654	COG4574	serine-type endopeptidase inhibitor activity
LC20_03656	COG0814	amino acid
LC20_03661	COG1441	menaquinone biosynthetic process
LC20_03662	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LC20_03663	COG0596	Alpha beta hydrolase
LC20_03664	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LC20_03665	COG1169	isochorismate synthase
LC20_03669	COG4575	ribosome binding
LC20_03671	COG4702	Belongs to the UPF0303 family
LC20_03674	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LC20_03677	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_03678	COG3265	gluconokinase activity
LC20_03683	COG1007	ATP synthesis coupled electron transport
LC20_03684	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_03685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LC20_03686	COG0713	ATP synthesis coupled electron transport
LC20_03687	COG0839	Belongs to the complex I subunit 6 family
LC20_03688	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_03689	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LC20_03690	COG1034	ATP synthesis coupled electron transport
LC20_03692	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LC20_03693	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_03693	COG0649	NAD binding
LC20_03694	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_03695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LC20_03696	COG0583	DNA-binding transcription factor activity
LC20_03699	COG0436	Aminotransferase
LC20_03700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LC20_03701	COG0471	metal ion transport
LC20_03701	COG0490	domain, Protein
LC20_03703	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LC20_03704	COG3013	Belongs to the UPF0304 family
LC20_03705	COG3092	negative regulation of chromosome organization
LC20_03708	COG0280	phosphate acetyltransferase
LC20_03708	COG0857	belongs to the CobB CobQ family
LC20_03709	COG1609	Transcriptional regulator
LC20_03710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_03712	COG3037	sugar-specific permease SgaT UlaA
LC20_03713	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LC20_03714	COG0622	Phosphoesterase
LC20_03718	COG1090	epimerase
LC20_03719	COG4598	ABC transporter
LC20_03720	COG4160	amino acid transport
LC20_03721	COG4215	(ABC) transporter
LC20_03722	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_03724	COG0163	prenyltransferase activity
LC20_03725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LC20_03726	COG1286	toxin biosynthetic process
LC20_03727	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LC20_03728	COG0285	dihydrofolate synthase activity
LC20_03729	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LC20_03730	COG0586	Pfam SNARE associated Golgi protein
LC20_03732	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LC20_03733	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LC20_03736	COG0697	spore germination
LC20_03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_03741	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LC20_03746	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LC20_03752	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LC20_03753	COG2723	6-phospho-beta-galactosidase activity
LC20_03754	COG1447	Phosphotransferase system cellobiose-specific component IIA
LC20_03756	COG1794	racemase activity, acting on amino acids and derivatives
LC20_03763	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LC20_03764	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LC20_03764	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LC20_03767	COG3101	peptidyl-lysine hydroxylation
LC20_03768	COG0730	response to heat
LC20_03769	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LC20_03770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LC20_03771	COG2890	protein-(glutamine-N5) methyltransferase activity
LC20_03772	COG2840	Smr protein MutS2
LC20_03773	COG2062	phosphohistidine phosphatase, SixA
LC20_03775	COG1250	3-hydroxyacyl-CoA dehydrogenase
LC20_03775	COG1024	Enoyl-CoA hydratase
LC20_03776	COG0183	Belongs to the thiolase family
LC20_03777	COG3691	Protein conserved in bacteria
LC20_03782	COG4235	cytochrome complex assembly
LC20_03782	COG3088	subunit of a heme lyase
LC20_03785	COG1138	Cytochrome C-type biogenesis protein
LC20_03786	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LC20_03787	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LC20_03788	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LC20_03790	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LC20_03798	COG3539	Fimbrial protein
LC20_03799	COG2824	Alkylphosphonate utilization operon protein PhnA
LC20_03801	COG1695	Transcriptional regulator
LC20_03803	COG2723	6-phospho-beta-galactosidase activity
LC20_03805	COG1263	PTS System
LC20_03805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LC20_03806	COG1609	Transcriptional regulator
LC20_03807	COG2353	YceI-like domain
LC20_03808	COG3038	cytochrome b561
LC20_03809	COG1902	pentaerythritol trinitrate reductase activity
LC20_03812	COG1127	ABC transporter
LC20_03818	COG0531	amino acid
LC20_03819	COG2951	lytic endotransglycosylase activity
LC20_03825	COG1280	lysine exporter protein (LysE YggA)
LC20_03828	COG2723	6-phospho-beta-galactosidase activity
LC20_03833	COG0243	molybdopterin cofactor binding
LC20_03835	COG0437	4 iron, 4 sulfur cluster binding
LC20_03838	COG3381	protein complex oligomerization
LC20_03841	COG1598	PFAM Uncharacterised protein family UPF0150
LC20_03843	COG3038	cytochrome b561
LC20_03849	COG3275	phosphorelay sensor kinase activity
LC20_03850	COG3279	Response regulator of the LytR AlgR family
LC20_03853	COG2223	nitrite transmembrane transporter activity
LC20_03861	COG0667	Aldo Keto reductase
LC20_03864	COG1914	H( )-stimulated, divalent metal cation uptake system
LC20_03866	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_03867	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LC20_03871	COG3530	Putative quorum-sensing-regulated virulence factor
LC20_03877	COG3778	Protein conserved in bacteria
LC20_03878	COG3299	homolog of phage Mu protein gp47
LC20_03888	COG4386	tail sheath protein
LC20_03897	COG4695	Portal protein
LC20_03898	COG4626	Terminase
LC20_03898	COG1802	Transcriptional regulator
LC20_03904	COG3179	chitinase
LC20_03912	COG1403	HNH endonuclease
LC20_03916	COG4725	Belongs to the MT-A70-like family
LC20_03918	COG4626	Terminase
LC20_03918	COG1802	Transcriptional regulator
LC20_03939	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LC20_03944	COG0582	viral genome integration into host DNA
LC20_03945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LC20_03947	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_03948	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LC20_03949	COG2190	(PTS) system
LC20_03950	COG2205	protein histidine kinase activity
LC20_03951	COG0745	RESPONSE REGULATOR receiver
LC20_03953	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_03959	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LC20_03963	COG1737	Transcriptional regulator
LC20_03965	COG2731	YhcH YjgK YiaL family protein
LC20_03968	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LC20_03969	COG2837	iron assimilation
LC20_03972	COG3111	PFAM Bacterial OB fold (BOF) protein
LC20_03973	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_03974	COG2897	thiosulfate sulfurtransferase activity
LC20_03979	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_03980	COG1129	ABC transporter
LC20_03982	COG0456	acetyltransferase
LC20_03983	COG0408	coproporphyrinogen oxidase activity
LC20_03988	COG0494	nUDIX hydrolase
LC20_03989	COG3005	denitrification pathway
LC20_03990	COG3043	anaerobic respiration
LC20_03991	COG0243	molybdopterin cofactor binding
LC20_03992	COG3062	negative regulation of establishment of protein localization
LC20_03994	COG2197	response regulator
LC20_03997	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_04001	COG1393	Belongs to the ArsC family
LC20_04002	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LC20_04003	COG1876	peptidase activity
LC20_04005	COG0400	carboxylic ester hydrolase activity
LC20_04009	COG1444	tRNA N-acetyltransferase activity
LC20_04010	COG2707	UPF0756 membrane protein
LC20_04011	COG2321	neutral zinc metallopeptidase
LC20_04012	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LC20_04013	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LC20_04014	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LC20_04015	COG2716	regulation of RNA biosynthetic process
LC20_04016	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LC20_04017	COG0628	permease
LC20_04019	COG4783	chaperone-mediated protein folding
LC20_04020	COG1393	Belongs to the ArsC family
LC20_04021	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LC20_04022	COG2233	PERMEase
LC20_04023	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LC20_04025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LC20_04026	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LC20_04027	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LC20_04029	COG0581	inorganic phosphate transmembrane transporter activity
LC20_04030	COG0573	inorganic phosphate transmembrane transporter activity
LC20_04031	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LC20_04032	COG0248	Ppx GppA phosphatase
LC20_04036	COG5002	protein histidine kinase activity
LC20_04036	COG5001	Diguanylate cyclase
LC20_04036	COG3447	MASE1 domain protein
LC20_04037	COG0443	Heat shock 70 kDa protein
LC20_04041	COG3121	Chaperone
LC20_04051	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_04053	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_04056	COG2205	protein histidine kinase activity
LC20_04057	COG0745	RESPONSE REGULATOR receiver
LC20_04058	COG3422	double-strand break repair
LC20_04064	COG3730	PTS system glucitol sorbitol-specific
LC20_04067	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_04068	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_04069	COG1349	DNA-binding transcription factor activity
LC20_04073	COG0351	phosphomethylpyrimidine kinase
LC20_04077	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LC20_04077	COG0519	Catalyzes the synthesis of GMP from XMP
LC20_04079	COG0516	GMP reductase activity
LC20_04079	COG0517	IMP dehydrogenase activity
LC20_04082	COG1645	bacterial-type flagellum-dependent swarming motility
LC20_04084	COG1160	GTP binding
LC20_04086	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LC20_04087	COG2976	Protein conserved in bacteria
LC20_04088	COG0124	histidyl-tRNA synthetase
LC20_04089	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LC20_04092	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LC20_04097	COG4953	penicillin-binding protein 1C
LC20_04098	COG2373	Large extracellular alpha-helical protein
LC20_04103	COG2975	iron-sulfur cluster assembly
LC20_04104	COG0633	Ferredoxin
LC20_04106	COG0443	Heat shock 70 kDa protein
LC20_04107	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LC20_04109	COG0822	iron-sulfur transferase activity
LC20_04111	COG1959	2 iron, 2 sulfur cluster binding
LC20_04112	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LC20_04113	COG0483	inositol monophosphate 1-phosphatase activity
LC20_04114	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LC20_04115	COG3683	transport system, periplasmic component
LC20_04118	COG3711	transcriptional antiterminator
LC20_04119	COG2814	Major facilitator Superfamily
LC20_04120	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LC20_04121	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LC20_04121	COG1017	nitric oxide dioxygenase activity
LC20_04122	COG2188	Transcriptional regulator
LC20_04124	COG3457	Alanine racemase
LC20_04125	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LC20_04128	COG0347	Belongs to the P(II) protein family
LC20_04129	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LC20_04129	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LC20_04130	COG2204	response regulator
LC20_04131	COG3170	Tfp pilus assembly protein FimV
LC20_04132	COG2205	protein histidine kinase activity
LC20_04136	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LC20_04137	COG0590	tRNA wobble adenosine to inosine editing
LC20_04140	COG0560	Phosphoserine phosphatase
LC20_04144	COG1737	Transcriptional regulator
LC20_04145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_04146	COG2610	gluconate transmembrane transporter activity
LC20_04147	COG0736	holo-[acyl-carrier-protein] synthase activity
LC20_04150	COG1381	Involved in DNA repair and RecF pathway recombination
LC20_04151	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LC20_04153	COG0681	Belongs to the peptidase S26 family
LC20_04154	COG0481	GTPase activity
LC20_04158	COG3086	response to oxidative stress
LC20_04160	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LC20_04162	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LC20_04163	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LC20_04164	COG0513	Belongs to the DEAD box helicase family
LC20_04168	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LC20_04170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LC20_04171	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LC20_04172	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LC20_04173	COG0497	DNA recombination
LC20_04174	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LC20_04176	COG2867	negative regulation of translational initiation
LC20_04187	COG5301	cellulose 1,4-beta-cellobiosidase activity
LC20_04206	COG4695	Portal protein
LC20_04217	COG4974	Belongs to the 'phage' integrase family
LC20_04234	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LC20_04235	COG4575	ribosome binding
LC20_04237	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_04238	COG1780	Probably involved in ribonucleotide reductase function
LC20_04240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LC20_04242	COG4176	ABC-type proline glycine betaine transport system permease component
LC20_04243	COG2113	Glycine betaine
LC20_04245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LC20_04247	COG2226	methyltransferase
LC20_04248	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LC20_04249	COG0741	lytic transglycosylase activity
LC20_04249	COG1388	LysM domain
LC20_04250	COG3021	interspecies interaction between organisms
LC20_04251	COG2814	Major facilitator Superfamily
LC20_04252	COG0583	DNA-binding transcription factor activity
LC20_04253	COG0656	L-ascorbic acid biosynthetic process
LC20_04255	COG0542	response to heat
LC20_04257	COG0564	pseudouridine synthase activity
LC20_04258	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LC20_04259	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LC20_04260	COG1605	Chorismate mutase
LC20_04260	COG0077	Prephenate dehydratase
LC20_04261	COG1605	Chorismate mutase
LC20_04261	COG0287	Prephenate dehydrogenase
LC20_04262	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LC20_04263	COG3279	Response regulator of the LytR AlgR family
LC20_04264	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LC20_04265	COG3137	Salt-induced outer membrane protein
LC20_04267	COG0335	large ribosomal subunit rRNA binding
LC20_04268	COG0336	Belongs to the RNA methyltransferase TrmD family
LC20_04269	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LC20_04270	COG0228	four-way junction DNA binding
LC20_04271	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LC20_04272	COG4137	Cytochrome C assembly protein
LC20_04273	COG4536	flavin adenine dinucleotide binding
LC20_04274	COG1854	S-ribosylhomocysteine lyase activity
LC20_04275	COG2918	glutathione biosynthetic process
LC20_04277	COG1238	metal cluster binding
LC20_04278	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LC20_04281	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LC20_04282	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LC20_04283	COG2137	regulation of response to DNA damage stimulus
LC20_04284	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LC20_04290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LC20_04291	COG3958	Transketolase
LC20_04292	COG3959	Transketolase, thiamine diphosphate binding domain
LC20_04293	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_04294	COG1129	ABC transporter
LC20_04296	COG1609	Transcriptional regulator
LC20_04297	COG3381	protein complex oligomerization
LC20_04298	COG3302	dmso reductase anchor subunit
LC20_04299	COG0437	4 iron, 4 sulfur cluster binding
LC20_04300	COG0243	molybdopterin cofactor binding
LC20_04301	COG0235	Class ii aldolase
LC20_04302	COG1349	DNA-binding transcription factor activity
LC20_04304	COG1129	ABC transporter
LC20_04305	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_04308	COG3623	hexulose-6-phosphate isomerase
LC20_04309	COG1070	Carbohydrate kinase
LC20_04311	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LC20_04311	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LC20_04315	COG0559	Belongs to the binding-protein-dependent transport system permease family
LC20_04317	COG1137	ATPase activity
LC20_04318	COG0410	ABC transporter
LC20_04332	COG0640	Transcriptional regulator
LC20_04333	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LC20_04334	COG3158	transport of potassium into the cell
LC20_04338	COG1126	abc transporter atp-binding protein
LC20_04340	COG0765	amino acid transport
LC20_04347	COG3048	D-serine ammonia-lyase activity
LC20_04348	COG2610	gluconate transmembrane transporter activity
LC20_04349	COG0583	DNA-binding transcription factor activity
LC20_04350	COG4608	Belongs to the ABC transporter superfamily
LC20_04351	COG0444	Belongs to the ABC transporter superfamily
LC20_04353	COG0601	transmembrane transport
LC20_04354	COG0747	negative chemotaxis
LC20_04356	COG4948	Mandelate Racemase Muconate Lactonizing
LC20_04359	COG1858	cytochrome C peroxidase
LC20_04360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LC20_04362	COG1028	Short-chain dehydrogenase reductase Sdr
LC20_04366	COG1538	Outer membrane efflux protein
LC20_04367	COG0577	efflux transmembrane transporter activity
LC20_04367	COG1136	(ABC) transporter
LC20_04368	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_04371	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LC20_04374	COG3539	Fimbrial protein
LC20_04375	COG3539	Fimbrial protein
LC20_04377	COG3121	Chaperone
LC20_04378	COG3188	usher protein
LC20_04384	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LC20_04386	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LC20_04387	COG4942	peptidase
LC20_04387	COG1388	LysM domain
LC20_04389	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LC20_04390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LC20_04391	COG0585	pseudouridine synthase activity
LC20_04392	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LC20_04394	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LC20_04396	COG0765	amino acid transport
LC20_04400	COG0529	Catalyzes the synthesis of activated sulfate
LC20_04401	COG2895	sulfate adenylyltransferase (ATP) activity
LC20_04402	COG0175	sulfate reduction
LC20_04403	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LC20_04403	COG1648	precorrin-2 dehydrogenase activity
LC20_04404	COG2234	aminopeptidase activity
LC20_04405	COG0175	sulfate reduction
LC20_04406	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LC20_04407	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LC20_04409	COG0720	synthase
LC20_04410	COG0602	queuosine metabolic process
LC20_04412	COG0148	phosphopyruvate hydratase activity
LC20_04413	COG0504	CTP synthase activity
LC20_04415	COG3956	TIGRFAM MazG family protein
LC20_04417	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LC20_04418	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LC20_04419	COG3437	response regulator, receiver
LC20_04419	COG3850	Histidine kinase
LC20_04419	COG2205	protein histidine kinase activity
LC20_04419	COG4999	Histidine kinase
LC20_04420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LC20_04421	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LC20_04422	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LC20_04424	COG2860	membrane
LC20_04426	COG0316	Belongs to the HesB IscA family
LC20_04429	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LC20_04430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_04431	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LC20_04432	COG1120	ATPase activity
LC20_04433	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LC20_04435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LC20_04436	COG1489	DNA binding
LC20_04437	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LC20_04438	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LC20_04439	COG0617	tRNA 3'-terminal CCA addition
LC20_04440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LC20_04441	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LC20_04442	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LC20_04443	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LC20_04444	COG0726	polysaccharide deacetylase
LC20_04445	COG0842	Transport permease protein
LC20_04446	COG1131	(ABC) transporter
LC20_04447	COG0288	reversible hydration of carbon dioxide
LC20_04448	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LC20_04449	COG2132	Multicopper oxidase
LC20_04451	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LC20_04453	COG0697	spore germination
LC20_04456	COG3112	Uncharacterised protein family (UPF0231)
LC20_04457	COG1049	propionate catabolic process, 2-methylcitrate cycle
LC20_04469	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_04470	COG0508	dehydrogenase complex catalyzes the overall conversion of
LC20_04471	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LC20_04472	COG2186	Transcriptional regulator
LC20_04474	COG1113	amino acid transport
LC20_04481	COG3725	Membrane protein required for beta-lactamase induction
LC20_04482	COG3023	N-Acetylmuramoyl-L-alanine amidase
LC20_04487	COG3328	transposase activity
LC20_04488	COG0516	GMP reductase activity
LC20_04489	COG0237	dephospho-CoA kinase activity
LC20_04491	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LC20_04492	COG0494	nUDIX hydrolase
LC20_04494	COG0653	protein targeting
LC20_04498	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LC20_04499	COG0849	cell division
LC20_04500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LC20_04502	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LC20_04504	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LC20_04505	COG0772	Belongs to the SEDS family
LC20_04507	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LC20_04508	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LC20_04509	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LC20_04510	COG0768	penicillin binding
LC20_04511	COG3116	cell division
LC20_04512	COG0275	rRNA processing
LC20_04516	COG1609	Transcriptional regulator
LC20_04518	COG0028	Belongs to the TPP enzyme family
LC20_04520	COG1022	Amp-dependent synthetase and ligase
LC20_04523	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LC20_04524	COG0473	3-isopropylmalate dehydrogenase activity
LC20_04525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LC20_04527	COG3033	Beta-eliminating lyase
LC20_04528	COG0814	amino acid
LC20_04529	COG2814	Major facilitator Superfamily
LC20_04532	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LC20_04533	COG4533	DNA binding
LC20_04537	COG1178	ABC-type Fe3 transport system permease component
LC20_04539	COG0586	Pfam SNARE associated Golgi protein
LC20_04542	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LC20_04543	COG0564	pseudouridine synthase activity
LC20_04545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LC20_04546	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LC20_04547	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LC20_04548	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LC20_04550	COG2967	ApaG domain
LC20_04551	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LC20_04552	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LC20_04553	COG3610	response to peptide
LC20_04554	COG2966	Psort location CytoplasmicMembrane, score
LC20_04556	COG1280	lysine exporter protein (LysE YggA)
LC20_04557	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LC20_04558	COG0505	Belongs to the CarA family
LC20_04559	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LC20_04561	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LC20_04562	COG1047	Peptidyl-prolyl cis-trans
LC20_04563	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LC20_04564	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LC20_04565	COG0196	riboflavin kinase activity
LC20_04567	COG0583	DNA-binding transcription factor activity
LC20_04568	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LC20_04569	COG0484	heat shock protein binding
LC20_04571	COG1584	GPR1 FUN34 yaaH family protein
LC20_04574	COG0521	Mo-molybdopterin cofactor biosynthetic process
LC20_04576	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LC20_04577	COG3022	response to hydroperoxide
LC20_04579	COG0083	homoserine kinase activity
LC20_04582	COG0745	RESPONSE REGULATOR receiver
LC20_04583	COG3045	CreA protein
LC20_04584	COG2207	Transcriptional regulator
LC20_04584	COG3708	Transcriptional regulator
LC20_04585	COG0406	alpha-ribazole phosphatase activity
LC20_04586	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LC20_04587	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LC20_04588	COG0741	lytic transglycosylase activity
LC20_04589	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LC20_04591	COG2199	diguanylate cyclase activity
LC20_04592	COG2885	chlorophyll binding
LC20_04593	COG0488	(ABC) transporter
LC20_04595	COG0604	alcohol dehydrogenase
LC20_04600	COG0560	Phosphoserine phosphatase
LC20_04601	COG3726	membrane protein affecting hemolysin expression
LC20_04603	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LC20_04604	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LC20_04605	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LC20_04606	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_04607	COG0084	hydrolase, TatD family'
LC20_04608	COG4667	esterase of the alpha-beta hydrolase superfamily
LC20_04610	COG2823	Periplasmic or secreted lipoprotein
LC20_04611	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LC20_04613	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LC20_04614	COG2813	Specifically methylates the guanine in position
LC20_04615	COG0667	Aldo Keto reductase
LC20_04621	COG3706	GGDEF domain
LC20_04640	COG2192	nodulation
LC20_04642	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LC20_04642	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LC20_04642	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_04643	COG1461	Dihydroxyacetone kinase
LC20_04645	COG2376	Dihydroxyacetone kinase
LC20_04648	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LC20_04649	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LC20_04651	COG2235	arginine
LC20_04661	COG0859	PFAM glycosyl transferase family 9
LC20_04664	COG2390	Transcriptional regulator
LC20_04665	COG1129	ABC transporter
LC20_04666	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_04667	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_04668	COG1879	ABC-type sugar transport system periplasmic component
LC20_04669	COG1830	Aldolase
LC20_04670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LC20_04671	COG3272	Protein of unknown function (DUF1722)
LC20_04676	COG0454	-acetyltransferase
LC20_04678	COG0795	lipopolysaccharide-transporting ATPase activity
LC20_04679	COG0795	lipopolysaccharide-transporting ATPase activity
LC20_04680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LC20_04681	COG2927	DNA polymerase III (CHI subunit)
LC20_04685	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LC20_04687	COG2731	YhcH YjgK YiaL family protein
LC20_04689	COG0601	transmembrane transport
LC20_04691	COG0444	Belongs to the ABC transporter superfamily
LC20_04692	COG4608	Belongs to the ABC transporter superfamily
LC20_04694	COG2249	NAD(P)H dehydrogenase (quinone) activity
LC20_04695	COG0583	DNA-binding transcription factor activity
LC20_04697	COG0602	queuosine metabolic process
LC20_04701	COG2188	Transcriptional regulator
LC20_04702	COG3624	Phosphonate C-P lyase system protein PhnG
LC20_04703	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LC20_04704	COG3626	phosphonate metabolism
LC20_04705	COG3627	carbon phosphorus lyase activity
LC20_04706	COG4107	phosphonate C-P lyase system protein PhnK
LC20_04707	COG4778	phosphonate C-P lyase system protein PhnL
LC20_04708	COG3454	Phosphonate metabolism
LC20_04709	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LC20_04710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LC20_04711	COG0702	epimerase
LC20_04712	COG3787	Belongs to the UPF0306 family
LC20_04714	COG3842	ATPase activity
LC20_04715	COG0395	ABC-type sugar transport system, permease component
LC20_04717	COG1653	transport
LC20_04721	COG1982	Orn Lys Arg decarboxylase major
LC20_04722	COG0531	amino acid
LC20_04724	COG3153	acetyltransferase
LC20_04731	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LC20_04732	COG0513	Belongs to the DEAD box helicase family
LC20_04734	COG1185	polyribonucleotide nucleotidyltransferase activity
LC20_04736	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LC20_04737	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LC20_04739	COG0195	Participates in both transcription termination and antitermination
LC20_04742	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LC20_04744	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LC20_04747	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LC20_04748	COG1534	Rna-binding protein
LC20_04749	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LC20_04750	COG2027	D-alanyl-D-alanine carboxypeptidase
LC20_04751	COG0745	RESPONSE REGULATOR receiver
LC20_04752	COG0642	Histidine kinase
LC20_04753	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LC20_04754	COG0697	spore germination
LC20_04757	COG0142	geranyltranstransferase activity
LC20_04759	COG3423	Transcriptional regulator
LC20_04762	COG1438	arginine binding
LC20_04764	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LC20_04765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LC20_04766	COG0840	transmembrane signaling receptor activity
LC20_04768	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LC20_04769	COG2105	PFAM AIG2 family protein
LC20_04770	COG2911	Protein conserved in bacteria
LC20_04771	COG0729	surface antigen
LC20_04772	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LC20_04773	COG1253	flavin adenine dinucleotide binding
LC20_04775	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LC20_04776	COG1218	3'(2'),5'-bisphosphate nucleotidase
LC20_04778	COG0737	Belongs to the 5'-nucleotidase family
LC20_04780	COG0545	Peptidyl-prolyl cis-trans isomerase
LC20_04781	COG3061	Opacity-associated protein A
LC20_04783	COG0359	binds to the 23S rRNA
LC20_04784	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LC20_04786	COG0360	Binds together with S18 to 16S ribosomal RNA
LC20_04788	COG1073	alpha beta
LC20_04790	COG3650	response to hydrogen peroxide
LC20_04791	COG1960	acyl-CoA dehydrogenase activity
LC20_04792	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LC20_04793	COG0557	exoribonuclease II activity
LC20_04794	COG1959	2 iron, 2 sulfur cluster binding
LC20_04795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LC20_04796	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LC20_04800	COG0330	HflC and HflK could
LC20_04801	COG0330	HflC and HflK could
LC20_04802	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LC20_04803	COG1923	regulation of RNA biosynthetic process
LC20_04804	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LC20_04805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LC20_04806	COG0860	N-Acetylmuramoyl-L-alanine amidase
LC20_04807	COG0802	atpase or kinase
LC20_04808	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LC20_04808	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LC20_04809	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LC20_04813	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LC20_04814	COG1162	GTPase activity
LC20_04815	COG0688	phosphatidylethanolamine metabolic process
LC20_04816	COG1511	domain protein
LC20_04816	COG3264	Mechanosensitive ion channel
LC20_04817	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LC20_04819	COG1053	succinate dehydrogenase
LC20_04820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LC20_04821	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LC20_04822	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LC20_04825	COG2076	Multidrug Resistance protein
LC20_04826	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LC20_04829	COG0459	protein refolding
LC20_04830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LC20_04835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LC20_04837	COG4232	protein-disulfide reductase activity
LC20_04838	COG3383	formate dehydrogenase (NAD+) activity
LC20_04844	COG3835	regulator
LC20_04846	COG2084	Dehydrogenase
LC20_04847	COG3836	Belongs to the HpcH HpaI aldolase family
LC20_04849	COG1309	transcriptional regulator
LC20_04858	COG3720	iron ion transport
LC20_04859	COG4558	Periplasmic binding protein
LC20_04860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LC20_04861	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LC20_04862	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LC20_04880	COG4774	siderophore transport
LC20_04882	COG1196	nuclear chromosome segregation
LC20_04882	COG3264	Mechanosensitive ion channel
LC20_04883	COG0425	Belongs to the sulfur carrier protein TusA family
LC20_04884	COG2391	methyltransferase activity
LC20_04920	COG1301	dicarboxylic acid transport
LC20_04921	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LC20_04922	COG3162	membrane
LC20_04923	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LC20_04926	COG0138	bifunctional purine biosynthesis protein purh
LC20_04927	COG0151	Belongs to the GarS family
LC20_04930	COG3068	Protein conserved in bacteria
LC20_04931	COG1515	deoxyribonuclease V activity
LC20_04932	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LC20_04933	COG2816	NAD+ diphosphatase activity
LC20_04934	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LC20_04935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LC20_04937	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LC20_04938	COG2104	thiamine diphosphate biosynthetic process
LC20_04939	COG2022	thiamine diphosphate biosynthetic process
LC20_04941	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LC20_04942	COG0085	RNA polymerase activity
LC20_04943	COG0222	ribosome binding
LC20_04947	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LC20_04948	COG0250	Participates in transcription elongation, termination and antitermination
LC20_04949	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LC20_04955	COG1072	(Pantothenic acid kinase))
LC20_04960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LC20_04961	COG1739	Uncharacterized protein family UPF0029
LC20_04964	COG1024	Enoyl-CoA hydratase
LC20_04964	COG1250	3-hydroxyacyl-CoA dehydrogenase
LC20_04965	COG0183	Belongs to the thiolase family
LC20_04967	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LC20_04975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LC20_04976	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LC20_04977	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LC20_04979	COG2226	methyltransferase
LC20_04980	COG1322	Protein conserved in bacteria
LC20_04981	COG0586	Pfam SNARE associated Golgi protein
LC20_04982	COG1966	Carbon starvation protein
LC20_04985	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LC20_04986	COG0412	Dienelactone hydrolase
LC20_04987	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LC20_04989	COG0679	Auxin Efflux Carrier
LC20_04990	COG0584	glycerophosphoryl diester phosphodiesterase
LC20_04991	COG3842	ATPase activity
LC20_04992	COG0395	ABC-type sugar transport system, permease component
LC20_04993	COG1175	transmembrane transport
LC20_04994	COG1653	transport
LC20_05005	COG0410	ABC transporter
LC20_05006	COG0411	ABC transporter
LC20_05007	COG4177	L-phenylalanine transmembrane transporter activity
LC20_05008	COG0559	Belongs to the binding-protein-dependent transport system permease family
LC20_05009	COG0683	leucine binding
LC20_05011	COG0456	acetyltransferase
LC20_05013	COG2177	Part of the ABC transporter FtsEX involved in
LC20_05014	COG2884	Cell division ATP-binding protein ftsE
LC20_05015	COG0552	protein localization to endoplasmic reticulum
LC20_05016	COG0742	ribosomal rna small subunit methyltransferase
LC20_05017	COG3776	membrane
LC20_05020	COG3714	YhhN family
LC20_05022	COG0425	Belongs to the sulfur carrier protein TusA family
LC20_05024	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LC20_05026	COG0247	lactate metabolic process
LC20_05028	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LC20_05030	COG2271	Major facilitator Superfamily
LC20_05031	COG0584	glycerophosphoryl diester phosphodiesterase
LC20_05033	COG0561	phosphatase activity
LC20_05034	COG2267	carboxylic ester hydrolase activity
LC20_05035	COG1280	lysine exporter protein (LysE YggA)
LC20_05036	COG1280	lysine exporter protein (LysE YggA)
LC20_05037	COG0514	ATP-dependent DNA helicase (RecQ)
LC20_05038	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LC20_05039	COG2050	protein possibly involved in aromatic compounds catabolism
LC20_05041	COG0598	Magnesium transport protein CorA
LC20_05043	COG5564	TIM-barrel signal transduction protein
LC20_05045	COG5441	Belongs to the UPF0261 family
LC20_05047	COG0210	DNA helicase
LC20_05048	COG1011	Hydrolase
LC20_05049	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LC20_05050	COG3159	Protein conserved in bacteria
LC20_05051	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LC20_05052	COG5567	small periplasmic lipoprotein
LC20_05053	COG1965	Belongs to the frataxin family
LC20_05054	COG3072	Adenylate cyclase
LC20_05055	COG0181	hydroxymethylbilane synthase activity
LC20_05056	COG1587	Uroporphyrinogen-III synthase
LC20_05057	COG2959	enzyme of heme biosynthesis
LC20_05058	COG3071	HemY protein
LC20_05061	COG1113	amino acid transport
LC20_05064	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LC20_05065	COG2244	polysaccharide biosynthetic process
LC20_05066	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LC20_05067	COG0456	acetyltransferase
LC20_05068	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LC20_05070	COG1088	dTDP-glucose 4,6-dehydratase activity
LC20_05071	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LC20_05072	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LC20_05073	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LC20_05074	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LC20_05076	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LC20_05077	COG3118	belongs to the thioredoxin family
LC20_05079	COG0248	Ppx GppA phosphatase
LC20_05083	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LC20_05087	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LC20_05089	COG0583	DNA-binding transcription factor activity
LC20_05090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LC20_05091	COG0129	dihydroxy-acid dehydratase activity
LC20_05092	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LC20_05093	COG3978	acetolactate synthase activity
LC20_05105	COG3085	chromosome segregation
LC20_05108	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_05109	COG1172	Belongs to the binding-protein-dependent transport system permease family
LC20_05110	COG1129	ABC transporter
LC20_05111	COG1879	ABC-type sugar transport system periplasmic component
LC20_05112	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LC20_05114	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LC20_05116	COG1309	transcriptional regulator
LC20_05117	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_05120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_05120	COG0678	peroxiredoxin activity
LC20_05121	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LC20_05131	COG1629	transport
LC20_05132	COG0165	Argininosuccinate lyase
LC20_05134	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LC20_05138	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LC20_05141	COG0460	homoserine dehydrogenase
LC20_05141	COG0527	aspartate kinase activity
LC20_05142	COG0626	cystathionine gamma-synthase activity
LC20_05144	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LC20_05147	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LC20_05148	COG1609	Transcriptional regulator
LC20_05149	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LC20_05151	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LC20_05152	COG1575	Belongs to the MenA family. Type 1 subfamily
LC20_05153	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LC20_05154	COG3074	FtsZ-dependent cytokinesis
LC20_05155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LC20_05157	COG1494	fructose-1,6-bisphosphatase
LC20_05158	COG2814	Major facilitator Superfamily
LC20_05161	COG3152	Membrane
LC20_05163	COG0149	triose-phosphate isomerase activity
LC20_05165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LC20_05167	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LC20_05168	COG3678	ATP-independent chaperone mediated protein folding
LC20_05169	COG0745	RESPONSE REGULATOR receiver
LC20_05170	COG2205	protein histidine kinase activity
LC20_05171	COG2169	Transcriptional regulator
LC20_05171	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LC20_05172	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LC20_05173	COG1045	serine acetyltransferase
LC20_05174	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LC20_05175	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LC20_05176	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LC20_05177	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LC20_05178	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LC20_05179	COG4942	peptidase
LC20_05180	COG2861	carbohydrate metabolic process
LC20_05182	COG0156	8-amino-7-oxononanoate synthase activity
LC20_05183	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LC20_05184	COG0859	PFAM glycosyl transferase family 9
LC20_05185	COG0859	PFAM glycosyl transferase family 9
LC20_05187	COG1519	Transferase
LC20_05189	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LC20_05191	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LC20_05192	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LC20_05194	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LC20_05195	COG0756	dUTP diphosphatase activity
LC20_05196	COG1309	transcriptional regulator
LC20_05197	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LC20_05199	COG1561	YicC-like family, N-terminal region
LC20_05219	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LC20_05221	COG2860	membrane
LC20_05222	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LC20_05225	COG1758	RNA polymerase activity
LC20_05226	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LC20_05227	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LC20_05228	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LC20_05231	COG2233	PERMEase
LC20_05232	COG2982	Protein involved in outer membrane biogenesis
LC20_05235	COG3423	Transcriptional regulator
LC20_05237	COG0456	acetyltransferase
LC20_05238	COG1490	D-aminoacyl-tRNA deacylase activity
LC20_05239	COG1295	ribonuclease BN
LC20_05240	COG1011	Hydrolase
LC20_05243	COG0174	glutamine synthetase
LC20_05244	COG3852	Histidine kinase
LC20_05246	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LC20_05247	COG3078	GTPase activator activity
LC20_05248	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LC20_05250	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LC20_05250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LC20_05251	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LC20_05252	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LC20_05255	COG1763	Mo-molybdopterin cofactor biosynthetic process
LC20_05256	COG2186	Transcriptional regulator
LC20_05258	COG0477	Major facilitator Superfamily
LC20_05259	COG1609	Transcriptional regulator
LC20_05260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LC20_05261	COG1879	ABC-type sugar transport system periplasmic component
LC20_05263	COG1129	ABC transporter
LC20_05264	COG1869	D-ribose catabolic process
LC20_05277	COG1522	sequence-specific DNA binding
LC20_05278	COG0716	FMN binding
LC20_05279	COG0445	tRNA wobble uridine modification
LC20_05280	COG0357	Ribosomal RNA small subunit methyltransferase G
LC20_05281	COG3312	ion transport
LC20_05282	COG0356	it plays a direct role in the translocation of protons across the membrane
LC20_05284	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LC20_05285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LC20_05286	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LC20_05287	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LC20_05288	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LC20_05289	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LC20_05291	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LC20_05292	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LC20_05295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LC20_05296	COG0573	inorganic phosphate transmembrane transporter activity
LC20_05297	COG0581	inorganic phosphate transmembrane transporter activity
LC20_05300	COG0704	Plays a role in the regulation of phosphate uptake
LC20_05302	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LC20_05303	COG0765	amino acid transport
LC20_05304	COG0765	amino acid transport
LC20_05305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LC20_05307	COG2252	PERMEase
LC20_05311	COG0431	NADPH-dependent FMN reductase
LC20_05312	COG0840	transmembrane signaling receptor activity
LC20_05313	COG2011	ABC-type metal ion transport system permease component
LC20_05316	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LC20_05317	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LC20_05318	COG0706	membrane insertase activity
LC20_05319	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LC20_05322	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LC20_06014	COG3093	addiction module antidote protein HigA
LC20_06015	COG3549	Plasmid maintenance system killer
LC20_06203	COG3316	Transposase and inactivated derivatives
LC20_06224	COG1192	Involved in chromosome partitioning
LC20_06231	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_06238	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_06350	COG3962	Belongs to the TPP enzyme family
LC20_06355	COG1523	belongs to the glycosyl hydrolase 13 family
LC20_06370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LC20_06390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LC20_06395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LC20_06400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LC20_06415	COG4695	Portal protein
LC20_06475	COG3328	transposase activity
LC20_06505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LC20_06540	COG2200	EAL domain
LC20_06540	COG2199	diguanylate cyclase activity
LC20_06545	COG3164	Protein of unknown function
LC20_06610	COG3316	Transposase and inactivated derivatives
LC20_06615	COG3316	Transposase and inactivated derivatives
LC20_06620	COG3316	Transposase and inactivated derivatives
LC20_06640	COG3316	Transposase and inactivated derivatives
LC20_06675	COG3150	esterase
LC20_06800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LC20_06815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LC20_06840	COG3328	transposase activity
LC20_06860	COG3328	transposase activity
LC20_06865	COG4967	type IV pilus modification protein PilV
LC20_06870	COG1074	ATP-dependent DNA helicase activity
LC20_06890	COG1611	Belongs to the LOG family
LC20_06900	COG0587	DNA-directed DNA polymerase activity
LC20_06905	COG4568	rho-dependent transcription termination
LC20_06910	COG1720	tRNA m6t6A37 methyltransferase activity
LC20_06960	COG0765	amino acid transport
LC20_06970	COG1805	sodium ion transport
LC20_06980	COG2974	May be involved in recombination
LC20_06985	COG0419	ATPase involved in DNA repair
LC20_07015	COG0803	Belongs to the bacterial solute-binding protein 9 family
LC20_07025	COG1215	transferase activity, transferring glycosyl groups
LC20_07035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LC20_07160	COG3790	cyd operon protein YbgE
LC20_07215	COG4197	protein conserved in bacteria, prophage-related
LC20_07260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LC20_07290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LC20_07295	COG1403	HNH endonuclease
LC20_07305	COG1732	Glycine betaine
LC20_07345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LC20_07350	COG0438	transferase activity, transferring glycosyl groups
LC20_07360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LC20_07395	COG3121	Chaperone
LC20_07410	COG1278	Cold shock
LC20_07470	COG3136	membrane protein required for alginate biosynthesis
LC20_07500	COG3328	transposase activity
LC20_07505	COG3328	transposase activity
LC20_07525	COG3122	Protein conserved in bacteria
LC20_07535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LC20_07540	COG3138	arginine N-succinyltransferase
LC20_07555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LC20_07590	COG3142	Participates in the control of copper homeostasis
LC20_07605	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LC20_07610	COG3065	identical protein binding
LC20_07625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LC20_07645	COG0708	Exodeoxyribonuclease III
LC20_07675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LC20_07715	COG0671	phosphoesterase, PA-phosphatase related
LC20_07740	COG0284	orotidine-5'-phosphate decarboxylase activity
LC20_07750	COG0243	molybdopterin cofactor binding
LC20_07785	COG2197	response regulator
LC20_07790	COG3210	domain, Protein
LC20_07790	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_07790	COG3210	domain, Protein
LC20_07790	COG3064	Membrane
LC20_07790	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
LC20_07790	COG3064	Membrane
LC20_07795	COG3188	usher protein
LC20_07815	COG1643	Atp-dependent helicase
LC20_07820	COG0823	Involved in the tonB-independent uptake of proteins
LC20_07875	COG1609	Transcriptional regulator
LC20_07905	COG4558	Periplasmic binding protein
LC20_07910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LC20_07925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LC20_07930	COG1811	Na channel or pump
LC20_07945	COG1121	(ABC) transporter
LC20_07950	COG0793	Belongs to the peptidase S41A family
LC20_07955	COG2995	paraquat-inducible protein a
LC20_08030	COG1278	Cold shock
LC20_08145	COG3130	regulation of translation
LC20_08200	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LC20_08230	COG4239	(ABC) transporter, permease
LC20_08260	COG3328	transposase activity
LC20_08285	COG3328	transposase activity
LC20_08295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LC20_08310	COG3302	dmso reductase anchor subunit
LC20_08320	COG0436	Aminotransferase
LC20_08415	COG4208	sulfate ABC transporter
LC20_08450	COG2239	Acts as a magnesium transporter
LC20_08470	COG0477	Major facilitator Superfamily
LC20_08475	COG1570	exodeoxyribonuclease VII activity
LC20_08495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LC20_08635	COG3328	transposase activity
LC20_08655	COG4143	(ABC) transporter
LC20_08660	COG0417	DNA replication proofreading
LC20_08735	COG1070	Carbohydrate kinase
LC20_08775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LC20_08780	COG0039	L-malate dehydrogenase activity
LC20_08785	COG2965	DNA replication, synthesis of RNA primer
LC20_08815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LC20_08855	COG1960	acyl-CoA dehydrogenase activity
LC20_08960	COG0805	protein transport
LC20_08965	COG0583	DNA-binding transcription factor activity
LC20_09025	COG0583	DNA-binding transcription factor activity
LC20_09095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LC20_09125	COG3328	transposase activity
LC20_09140	COG0786	glutamate:sodium symporter activity
LC20_09200	COG0594	ribonuclease P activity
LC20_09215	COG3328	transposase activity
LC20_09250	COG3328	transposase activity
LC20_09335	COG2337	Toxic component of a toxin-antitoxin (TA) module