locus-tag class description CH47_1 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH47_10 ENOG4105C45 hydrogenase expression formation protein (HypE) CH47_1000 ENOG4107S90 membrAne CH47_1001 ENOG4106371 Methyltransferase CH47_1002 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) CH47_1003 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) CH47_1004 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) CH47_1005 ENOG4105DIT ErfK YbiS YcfS YnhG family protein CH47_1006 ENOG4105EAQ (twin-arginine translocation) pathway signal CH47_1007 ENOG4105C5X domain protein CH47_1008 ENOG4105BZU Histidine kinase CH47_1009 ENOG4105CGF Aromatic amino acid aminotransferase CH47_1011 ENOG4105C5S asparaginyl-tRNA synthetase CH47_1012 ENOG4107RH7 Nicotinate phosphoribosyltransferase CH47_1014 ENOG4105CD8 aminopeptidase N CH47_1015 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CH47_1016 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) CH47_1017 ENOG4105QVC MOSC domain-containing protein CH47_1018 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CH47_1019 ENOG4105C5H ABC transporter CH47_1020 ENOG4105F1S paraquat-inducible protein a CH47_1021 ENOG4105DY2 Paraquat-inducible protein b CH47_1022 ENOG4108Q2G (LipO)protein CH47_1023 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) CH47_1024 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH47_1026 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CH47_1027 ENOG4105DAN ATP-dependent protease CH47_1028 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) CH47_1029 ENOG4105UYK outer membrane protein a CH47_1030 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) CH47_1031 ENOG4108RZ1 DNA transformation protein CH47_1032 ENOG4105EM2 membrane CH47_1033 ENOG410901E Membrane CH47_1034 ENOG41088T4 Helicase IV CH47_1035 ENOG4108Z5K methylglyoxal synthase CH47_1036 ENOG4108Q67 UPF0319 protein CH47_1037 ENOG4105K4P CoA-binding domain protein CH47_1038 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) CH47_1039 ENOG4105DR4 Methyltransferase CH47_1042 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 CH47_1043 ENOG4108Z0T Part of a sulfur-relay system (By similarity) CH47_1045 ENOG4107YC3 synthase CH47_1046 ENOG4105VJY transcriptional regulator CH47_1048 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CH47_105 ENOG4105CXN decarboxylase CH47_1051 ENOG4105DJ9 glucan biosynthesis protein CH47_1052 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) CH47_1053 ENOG4105NAC (LipO)protein CH47_1055 ENOG4105DUX Transporter CH47_1056 ENOG4105C6X Major Facilitator CH47_1057 ENOG4108VGI doxx family CH47_1058 ENOG4105D1S lipid A biosynthesis CH47_1059 ENOG4108ZXC Two component transcriptional regulator, luxr family CH47_1060 ENOG4106AFQ Histidine kinase CH47_1061 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH47_1062 ENOG4106WHD Tetrathionate reductase CH47_1063 ENOG4105DB1 molybdopterin oxidoreductase CH47_1065 ENOG4105C72 UPF0176 protein CH47_1066 ENOG4105DSF transport protein CH47_1069 ENOG4105PVA Biofilm formation regulatory protein BssS CH47_107 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CH47_1071 ENOG4105EKE dihydroorotase CH47_1072 ENOG41067V3 Antibiotic biosynthesis monooxygenase CH47_1073 ENOG4105DQ6 Transposase CH47_1076 ENOG4107QQB Ribonuclease E CH47_1077 ENOG4105EI2 Pseudouridine synthase CH47_1079 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CH47_108 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) CH47_1080 ENOG4105VGS 50s ribosomal protein l32 CH47_1081 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CH47_1082 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CH47_1083 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CH47_1084 ENOG4105CHR reductase CH47_1086 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH47_1087 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CH47_1088 ENOG4105HHA aminodeoxychorismate lyase CH47_1089 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CH47_109 ENOG4105CEN a g-specific adenine glycosylase CH47_1090 ENOG4107QRG dna polymerase iii CH47_1091 ENOG4105F8V Hydrolase, tatD family CH47_1092 ENOG4105CI1 PTS System CH47_1093 ENOG4108JJA ABC, transporter CH47_1095 ENOG4105C4X radical SAM domain protein CH47_1097 ENOG4105F9E Shikimate 5-dehydrogenase CH47_1098 ENOG4105K59 histidine triad (HIT) protein CH47_1099 ENOG41090DQ Lipoprotein CH47_11 ENOG4105C8H hydrogenase maturation protein Hypf CH47_110 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CH47_1100 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) CH47_1101 ENOG4108RUM thiamine kinase CH47_1102 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CH47_1103 ENOG4105D0Y UPF0227 protein CH47_1104 ENOG4105CEP NADH dehydrogenase CH47_1105 ENOG4107MBR 17 kDa surface antigen CH47_1106 ENOG4108JA2 transcriptioN-repair coupling factor CH47_1107 ENOG4105D60 lipoprotein releasing system transmembrane protein CH47_1109 ENOG4105D60 lipoprotein releasing system transmembrane protein CH47_111 ENOG41090ED Protein with unknown function (DUF469) CH47_1110 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) CH47_1111 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CH47_1113 ENOG4105EZE Cupin 4 family protein CH47_1115 ENOG4105XJC Two component transcriptional regulator (Winged helix family CH47_1117 ENOG4107QTF adenylosuccinate lyase CH47_1118 ENOG41075W9 High frequency lysogenization protein HflD homolog CH47_1119 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CH47_112 ENOG4105CSV Glutaminase CH47_1121 ENOG4108R99 pseudouridine synthase CH47_1122 ENOG4108HMX isocitrate dehydrogenase (NADP) CH47_1126 ENOG4106NDP Transcriptional regulator CH47_113 ENOG4105K33 Periplasmic Protein CH47_1130 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CH47_1132 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CH47_1135 ENOG4105ECR NmrA family CH47_1136 ENOG4105KVH Transcriptional regulator CH47_114 ENOG4105CSA Coproporphyrinogen iii oxidase CH47_1140 ENOG4105DWP Membrane CH47_1142 ENOG4105VTN Protein of unknown function (DUF1311) CH47_1144 ENOG4105XXV Acid-resistance protein CH47_1147 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_115 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH47_1150 ENOG4105BZ1 (ABC) transporter CH47_1152 ENOG4105D5Q Arginine ornithine antiporter CH47_1156 ENOG4105N4N Protein of unknown function (DUF2766) CH47_1157 ENOG4105TIK CH47_1158 ENOG41064PC CH47_116 ENOG4105VZ9 UPF0235 protein CH47_1161 ENOG4105C85 amino acid CH47_1162 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) CH47_1163 ENOG410610J Protein of unknown function (DUF2627) CH47_1164 ENOG4105VEQ Cold shock protein CH47_1165 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CH47_1166 ENOG4105CJN penicillin-binding protein CH47_1167 ENOG4105DHI Methyltransferase CH47_1169 ENOG4105BZU Histidine kinase CH47_117 ENOG4108VIA integral membrane protein CH47_1171 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) CH47_1172 ENOG4108NK4 UPF0266 membrane protein CH47_1173 ENOG4105F3R pts system mannose fructose sorbose family iid CH47_1174 ENOG4105ETZ PTS System CH47_1175 ENOG4108EQA pts system CH47_1176 ENOG4105EE5 Membrane protein terC CH47_1178 ENOG4105EJQ L-serine dehydratase CH47_1179 ENOG4105P8F nudix hydrolase CH47_118 ENOG4105II7 pyrroline-5-carboxylate reductase CH47_1180 ENOG4105CRQ synthase (Component I) CH47_1181 ENOG4105X5C UPF0181 protein CH47_1182 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CH47_1183 ENOG4105C1J atp-dependent rna helicase CH47_1184 ENOG4105X2V dna damage-inducible protein CH47_1185 ENOG4105N5Z UPF0267 protein CH47_1187 ENOG4105CUG Oligopeptidase b CH47_1188 ENOG4105UMD exodeoxyribonuclease X CH47_1189 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_119 ENOG4105DFA alanine racemase domain protein CH47_1192 ENOG4105MPK DNA polymerase III subunit theta CH47_1193 ENOG41090A1 ferritin CH47_1194 ENOG4105FXM Copper resistance protein CH47_1195 ENOG4108PNC copper resistance CH47_1196 ENOG4105NKT exported protein CH47_1197 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH47_1198 ENOG4105ZTC transcriptional activator, Ogr delta CH47_12 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CH47_120 ENOG4105CZX twitching motility protein CH47_1209 ENOG4108US3 tail fiber assembly CH47_1219 ENOG4105VXN addiction module toxin, RelE StbE family CH47_122 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) CH47_123 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CH47_1237 ENOG4105ED4 portal protein CH47_124 ENOG4108UJU UPF0301 protein CH47_1243 ENOG4105CMM transposase CH47_125 ENOG4105D7Z glutathione synthase CH47_1250 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 CH47_1252 ENOG4108T1M outer membrane protein x CH47_1253 ENOG4105DQ6 Transposase CH47_126 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CH47_1261 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CH47_1262 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CH47_1263 ENOG4105WH1 Two component transcriptional regulator luxr family CH47_1264 ENOG4105XVG cytoplasmic protein CH47_1265 ENOG4105RA2 Membrane CH47_127 ENOG4105RWS endonuclease I CH47_1270 ENOG4105HRS Antitermination protein CH47_1275 ENOG4105KUS lysozyme CH47_1277 ENOG4105FE9 pseudouridine synthase CH47_1278 ENOG4105D6U Sodium Glutamate Symporter CH47_1278 ENOG4105D6U Sodium Glutamate Symporter CH47_128 ENOG4105GPY SprT protein CH47_1282 ENOG4105D64 Mechanosensitive ion channel CH47_1283 ENOG4108SHQ Glutathione S-transferase CH47_1288 ENOG4105WT8 Protein of unknown function (DUF1480) CH47_129 ENOG41080HT Transcriptional regulator, arsr family CH47_1296 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH47_1298 ENOG4105DY2 Paraquat-inducible protein b CH47_1299 ENOG4105H2K paraquat-inducible protein a CH47_1300 ENOG4108ZGC gaf domain protein CH47_1302 ENOG4105CN1 protease CH47_1303 ENOG4105D0M Protease HtpX homolog CH47_1304 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_1309 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH47_1310 ENOG4105CAZ oligogalacturonide lyase CH47_1312 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CH47_1313 ENOG4108ETY sodium dicarboxylate symporter CH47_1314 ENOG4107K5X Membrane-bound metal-dependent hydrolase CH47_1315 ENOG4108PU9 oligogalacturonate-specific porin CH47_1316 ENOG4105WEM extracellular solute-binding protein CH47_1317 ENOG4108IJ9 (ABC) transporter CH47_1318 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CH47_1319 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CH47_132 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CH47_1320 ENOG41061NF Pectate lyase CH47_1321 ENOG4105CHR reductase CH47_1322 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) CH47_1323 ENOG4105M5J Cupin 2, conserved barrel domain protein CH47_1324 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 CH47_1325 ENOG4107PN8 YfeABCD locus regulator CH47_1326 ENOG4105CYC Transferase CH47_1327 ENOG4105DEQ transcriptional regulator CH47_1328 ENOG4108M7F enoyl-CoA hydratase isomerase CH47_1329 ENOG4105DJT lAO AO transport system ATPase CH47_133 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) CH47_1330 ENOG4105D5P Methylmalonyl-coA mutase CH47_1331 ENOG4105FGM Fructosamine kinase CH47_1332 ENOG4105CC5 ABC transporter CH47_1333 ENOG4105CC5 ABC transporter CH47_1334 ENOG4105DIK (ABC) transporter CH47_1335 ENOG4105DSE periplasmic solute binding protein CH47_1336 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division CH47_1337 ENOG41082NP Multiple antibiotic resistance CH47_1345 ENOG41087WU CH47_1346 ENOG4105C22 threonyL-tRNA synthetase CH47_1347 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CH47_1348 ENOG41082NX 50s ribosomal protein l35 CH47_1349 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CH47_135 ENOG4108K0D peptidase, M48 CH47_1350 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CH47_1352 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CH47_136 ENOG4105CV1 Transketolase (EC 2.2.1.1) CH47_1362 ENOG4105YB8 TM2 domain containing protein CH47_1363 ENOG4105C26 Dehydrogenase CH47_1364 ENOG4105CK7 Sodium proline symporter CH47_1368 ENOG4105GMB type VI secretion system effector, hcp1 family CH47_1373 ENOG4105CS1 NAD(P)H quinone oxidoreductase CH47_1375 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) CH47_1376 ENOG4105C2W permease CH47_1377 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CH47_1378 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) CH47_1379 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CH47_1380 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) CH47_1381 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) CH47_1382 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) CH47_1383 ENOG4108R86 Transcriptional regulator CH47_1395 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CH47_1400 ENOG4105E5K Alpha-amylase CH47_1402 ENOG4107QM5 aconitate hydratase CH47_1403 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CH47_1404 ENOG4105EYK Phosphatidylglycerophosphatase B CH47_1405 ENOG4105Q4A inner membrane protein yciS CH47_1406 ENOG4105CFV Tetratricopeptide repeat protein CH47_1408 ENOG4105DKK Benzoate CH47_1409 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction CH47_1410 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CH47_1411 ENOG4108ZJT translation initiation factor, Sui1 CH47_1412 ENOG41061RM osmotically inducible lipoprotein CH47_1413 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CH47_1415 ENOG4105N2W Transcriptional regulator CH47_1416 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CH47_1417 ENOG4105VCD cytoplasmic protein CH47_1418 ENOG4105D22 carbon starvation protein CH47_1419 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) CH47_1420 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CH47_1424 ENOG4105CSM endonuclease III CH47_1426 ENOG4108UQQ Electron transport complex CH47_1427 ENOG4105D6A Electron transport complex CH47_1428 ENOG4105UEI Transcriptional Regulator AraC Family CH47_1429 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CH47_143 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CH47_1431 ENOG4105DGN Electron transport complex CH47_1432 ENOG4105M9B inner membrane protein ydgK CH47_1433 ENOG4105CKU formyltetrahydrofolate synthetase CH47_1435 ENOG4105C42 Type I secretion membrane fusion protein (HlyD CH47_1437 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) CH47_1439 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator CH47_144 ENOG4105BZA Phosphoglycerate kinase CH47_1441 ENOG4105CNN ABC, transporter CH47_1443 ENOG4105D9R oxidoreductase CH47_1444 ENOG4105DHU Bile acid CH47_1445 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CH47_1446 ENOG4105C87 Aminotransferase class I and II CH47_1447 ENOG4105CI1 PTS System CH47_1449 ENOG4107P2S Transcriptional regulator CH47_145 ENOG4105D2N Aldolase CH47_1450 ENOG4106J39 exported protein CH47_1451 ENOG4105EIP mannose-6-phosphate isomerase CH47_1452 ENOG4105C9Q fumarate hydratase class II CH47_1454 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) CH47_1457 ENOG4105D94 Major Facilitator Superfamily CH47_1458 ENOG4106NZI LysR family Transcriptional regulator CH47_1459 ENOG4105DAG ROK family CH47_146 ENOG4105D64 Mechanosensitive ion channel CH47_1460 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CH47_1462 ENOG4105KBG Protein of unknown function (DUF1161) CH47_1463 ENOG4105M5Q UPF0482 protein CH47_1465 ENOG4105KK4 UPF0060 membrane protein CH47_1466 ENOG4105EMU Dehydrogenase CH47_1467 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH47_1468 ENOG4105TDT uncharacterized protein yahO CH47_147 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CH47_1475 ENOG4105CYM Glutathione S-transferase CH47_1477 ENOG4108RYR transcriptional regulator AsnC family CH47_1479 ENOG4105DSP amino acid AbC transporter CH47_148 ENOG4105MPN Membrane CH47_1480 ENOG4105E89 ABC transporter CH47_1481 ENOG4106V2I dimethylaminohydrolase CH47_1483 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CH47_1486 ENOG4107ZHV Transcriptional regulator CH47_1487 ENOG41064T2 transcriptional regulator, lysR family CH47_1488 ENOG4105FYV Amp nucleosidase CH47_1489 ENOG4105ETE Transcriptional regulator (LacI family CH47_149 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CH47_1491 ENOG4105CXY transporter CH47_1495 ENOG4105C7K acetolactate synthase CH47_1496 ENOG4105M71 acetolactate synthase 1 regulatory subunit CH47_1497 ENOG4105PAD Hydrolase CH47_150 ENOG4105E66 phosphoriboisomerase A CH47_1501 ENOG4105EDR glucose galactose transporter CH47_1502 ENOG4108RVA ribokinase CH47_1504 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CH47_1505 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) CH47_1508 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH47_1509 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CH47_151 ENOG4108JQ1 Dehydrogenase CH47_1510 ENOG4105Q9Y Universal stress protein CH47_1511 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH47_1512 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CH47_1513 ENOG4105C5D exported protein CH47_1514 ENOG4105D5Q Arginine ornithine antiporter CH47_1516 ENOG4107EXC regulatoR CH47_1517 ENOG4105JJR Histidine kinase CH47_1518 ENOG4105CTD carboxy-peptidase CH47_152 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CH47_1520 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap CH47_1523 ENOG4105CQ7 ATP-dependent helicase CH47_1525 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CH47_1527 ENOG4105WXT Conserved Protein CH47_1528 ENOG410689M (LipO)protein CH47_1529 ENOG4107H52 Dicarboxylate transport CH47_153 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CH47_1530 ENOG4105C5I Dehydrogenase CH47_1532 ENOG4105KT7 mgtC SapB transporter CH47_1534 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) CH47_1535 ENOG4105CS2 ec 3.2.1.21 CH47_1536 ENOG4105C5Y PTS System CH47_1537 ENOG4105CID antiterminator CH47_1538 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CH47_1539 ENOG4107RX3 Mg2 transporter protein cora family protein CH47_154 ENOG4105E07 UPF0149 protein CH47_1541 ENOG4107QSI ABC, transporter CH47_1542 ENOG4107S8C mandelate racemase muconate lactonizing CH47_1543 ENOG4105KXI murein peptide amidase A CH47_1544 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CH47_1548 ENOG4106K28 UPF0283 membrane protein CH47_1549 ENOG4105CM6 amino acid regulated cytosolic protein CH47_155 ENOG4107RAQ aminopeptidase CH47_1551 ENOG4105FM1 phage shock protein C CH47_1552 ENOG4105YYT phage shock protein B CH47_1553 ENOG41087YS Phage shock protein A CH47_1554 ENOG4105E51 psp operon transcriptional activator CH47_1556 ENOG4106DF6 pertussis toxin subunit 1 CH47_1557 ENOG4108HIY periplasmic CH47_1558 ENOG4108I5W peptide transport system, permease protein CH47_1559 ENOG4108EU3 peptide transport system, permease CH47_156 ENOG4105D0A hydroxylase CH47_1560 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein CH47_1561 ENOG4108JQ2 peptide transport system atp-binding protein CH47_1563 ENOG4105Q4T oxidoreductase CH47_1564 ENOG4105DUM transcriptional regulator, lysR family CH47_1565 ENOG4105DUX Transporter CH47_1567 ENOG41069YE inner membrane protein yohC CH47_1568 ENOG4108ZR5 Conserved Protein CH47_1569 ENOG4108K3A Glutathione S-transferase CH47_157 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CH47_1571 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CH47_1572 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CH47_1573 ENOG410642K Lysozyme inhibitor CH47_1574 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CH47_1575 ENOG4108XTF Outer Membrane Lipoprotein CH47_1576 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CH47_1578 ENOG4105Y49 secretion protein, HlyD family CH47_1579 ENOG4105DSW Fusaric acid resistance protein CH47_158 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CH47_1580 ENOG4107RGM aldo keto reductase CH47_1581 ENOG4105XZD Fe-S protein CH47_1582 ENOG4105DIJ Phosphoethanolamine transferase CH47_1583 ENOG4108WUH Transcriptional regulator, TetR family CH47_1584 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH47_1585 ENOG4108UYE Lactoylglutathione lyase CH47_1586 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CH47_1587 ENOG4105M2J Glutaredoxin CH47_1588 ENOG4105K4H Nlp p60 protein CH47_1589 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH47_159 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CH47_1591 ENOG4105ETE Transcriptional regulator (LacI family CH47_1592 ENOG4105F52 Transcriptional regulator CH47_1593 ENOG4105CZQ inner membrane transport protein YdhC CH47_1594 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CH47_1595 ENOG4108R6K riboflavin synthase, subunit alpha CH47_1596 ENOG4107QI1 Mate efflux family protein CH47_160 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CH47_1600 ENOG4105CA9 Pyruvate kinase CH47_1601 ENOG4105KMX major outer membrane lipoprotein CH47_1602 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CH47_1603 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CH47_1605 ENOG4105JRK feS assembly protein SufD CH47_1606 ENOG4105C3K feS assembly ATPase SufC CH47_1607 ENOG4105DIW FeS assembly protein SUFB CH47_1608 ENOG4108Z4V iron-sulfur cluster assembly CH47_1609 ENOG4105KA0 thioesterase Superfamily protein CH47_1610 ENOG4105CQB FAD linked oxidase domain protein CH47_1611 ENOG4105IPI Membrane CH47_1612 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CH47_1613 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CH47_1614 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH47_1615 ENOG4107ENK receptor CH47_1616 ENOG4106QJH hemin transport protein CH47_1617 ENOG4107R4I Periplasmic binding protein CH47_1619 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) CH47_1620 ENOG4108QBX (LipO)protein CH47_1621 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CH47_1622 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CH47_1623 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CH47_1624 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CH47_1625 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CH47_1626 ENOG4105CKK Glycosyl transferase, family 2 CH47_1627 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CH47_1628 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) CH47_1629 ENOG4108V06 Glutathione peroxidase CH47_163 ENOG4108UT2 hemolysin iii CH47_1630 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CH47_1632 ENOG4107R11 Transcriptional regulator CH47_1633 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH47_1634 ENOG4105RKX Protein of unknown function (DUF2498) CH47_1635 ENOG4105ERU peptidase CH47_1636 ENOG4105UBK short-chain dehydrogenase reductase CH47_1637 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CH47_1638 ENOG4105FE9 pseudouridine synthase CH47_1639 ENOG4107RTD sua5 ycio yrdc ywlc family protein CH47_164 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CH47_1640 ENOG4105DB7 PHP domain protein CH47_1642 ENOG4105DDQ anthranilate synthase CH47_1644 ENOG4105DK0 Indole-3-glycerol phosphate synthase CH47_1645 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CH47_1646 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CH47_1648 ENOG4105EIF outer membrane protein W CH47_1649 ENOG4105PI0 Ferredoxin CH47_165 ENOG4105Y75 tpr repeat protein CH47_1650 ENOG4108S3I UPF0259 membrane protein CH47_1652 ENOG4107835 probably involved in intracellular septation (By similarity) CH47_1653 ENOG4105NAU thioesterase Superfamily protein CH47_1654 ENOG410822N TonB family CH47_1655 ENOG4105K9H YciI-like protein CH47_1658 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CH47_1659 ENOG4108W5H UPF0263 protein CH47_1660 ENOG4108JQ7 (ABC) transporter CH47_1661 ENOG4105C3U ABC transporter CH47_1662 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH47_1663 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH47_1664 ENOG4107QSI ABC, transporter CH47_1665 ENOG4108J59 Extracellular solute-binding protein, family 5 CH47_1666 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CH47_1667 ENOG4108EKI Dehydrogenase CH47_1669 ENOG4107104 thymidine kinase CH47_167 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH47_1671 ENOG4105C6Y Udp-glucose 6-dehydrogenase CH47_1672 ENOG4105I93 response regulator CH47_1673 ENOG4105D78 K07001 NTE family protein CH47_1675 ENOG4105K5B UPF0225 protein CH47_1676 ENOG4105CIY formyltetrahydrofolate deformylase CH47_168 ENOG4105EB3 Histidine kinase CH47_1680 ENOG4105SKE transcriptional Regulator LysR family CH47_1681 ENOG4105CGK Exodeoxyribonuclease III CH47_1682 ENOG4105M6F mutator MutT protein CH47_1683 ENOG4105MTM Protein of unknown function (DUF1496) CH47_1684 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CH47_1686 ENOG41069NU Nitroreductase CH47_1687 ENOG4105D07 Signal peptide peptidase, SppA CH47_1688 ENOG4105HDK L-asparaginase CH47_1689 ENOG4108RWI nicotinamidase CH47_169 ENOG4105CT7 inner membrane cred family protein CH47_1690 ENOG4105VUT cytoplasmic protein CH47_1691 ENOG4105E0X reductase CH47_1695 ENOG4105DSB aldose 1-epimerase CH47_1697 ENOG4105GNX MltA-interacting MipA family protein CH47_1698 ENOG4105CYN Serine protein kinase CH47_1699 ENOG4106AKX UPF0229 protein CH47_17 ENOG4105CSH Transporter CH47_170 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) CH47_1702 ENOG4105HEI LysR family (Transcriptional regulator CH47_1703 ENOG4105EUB pirin domain protein CH47_1704 ENOG4105BZU Histidine kinase CH47_1705 ENOG4105CNH Multidrug resistance protein MdtL CH47_1706 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CH47_1707 ENOG4105MWK D-amino acid dehydrogenase, small subunit CH47_1708 ENOG4105ED1 spovr family CH47_1709 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) CH47_171 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH47_1710 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CH47_1711 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) CH47_1712 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH47_1718 ENOG4107R08 Integrase CH47_1719 ENOG4108ZZ3 UPF0260 protein CH47_172 ENOG4105T95 Thiol disulfide interChange protein CH47_1720 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CH47_1721 ENOG4105CVE Lytic murein transglycosylase CH47_1722 ENOG4105VNG YcgL domain-containing protein CH47_1724 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CH47_1725 ENOG4107QMS site-determining protein CH47_1726 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CH47_1727 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CH47_1728 ENOG4105CEY Amp-dependent synthetase and ligase CH47_1729 ENOG4105Y4Z Outer Membrane Lipoprotein CH47_173 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CH47_1730 ENOG41072GX Peptidase M22 Glycoprotease CH47_1731 ENOG4105DVT helicase CH47_1732 ENOG4105M4H endoribonuclease L-psp CH47_1734 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) CH47_1735 ENOG4108UHU Aldolase CH47_1736 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CH47_1737 ENOG4106KNT transcriptional regulator CH47_1738 ENOG4105CA9 Pyruvate kinase CH47_1739 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CH47_174 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CH47_1740 ENOG4105DR5 peptidase CH47_1741 ENOG4105NXV High-affinity zinc uptake system protein CH47_1742 ENOG4105FDK ABC transporter CH47_1743 ENOG4105FAV ABC, transporter CH47_1744 ENOG4105DUX Transporter CH47_1745 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CH47_1746 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CH47_1747 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CH47_1748 ENOG4105CDY transcriptional regulatory protein CH47_1749 ENOG4108TIT dATP pyrophosphohydrolase CH47_175 ENOG4105CRK lysyL-tRNA synthetase CH47_1751 ENOG4105C9M aspartyl-trna synthetase CH47_1752 ENOG4105D3W isochorismatase CH47_1753 ENOG41081XQ Conserved Protein CH47_1754 ENOG4105WJG Glutathione CH47_1755 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) CH47_1756 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CH47_1757 ENOG4106N3A copper homeostasis protein cutc CH47_1758 ENOG4106ZCM YecM protein CH47_1759 ENOG4105C75 arginyL-tRNA synthetase CH47_1762 ENOG4105CJR Integral membrane protein (MviN CH47_1763 ENOG4105EP9 oxidoreductase CH47_1765 ENOG4105D9U N-acetyltransferase CH47_1768 ENOG4105EV4 Multidrug resistance protein mdtH CH47_1769 ENOG4105F3T (LipO)protein CH47_1770 ENOG4107XHZ cytoplasmic chaperone TorD family protein CH47_1771 ENOG4107SSZ Phosphatase CH47_1772 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CH47_1776 ENOG4105BZU Histidine kinase CH47_1777 ENOG4105CHH sulfate transporter CH47_1778 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CH47_1779 ENOG41063JG Transcriptional regulator CH47_1780 ENOG4108YY7 Invasion gene expression up-regulator SirB CH47_1781 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CH47_1782 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CH47_1783 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CH47_1784 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CH47_1786 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CH47_1787 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria CH47_1788 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CH47_1790 ENOG4105C3G gtp-binding protein CH47_1791 ENOG41066YJ Beta-lactamase CH47_1793 ENOG4108Q2J Inner membrane protein YebE CH47_1799 ENOG4105E98 transcriptional regulator DeoR family CH47_1800 ENOG4105E70 isomerase CH47_1802 ENOG4108K5P (LipO)protein CH47_1806 ENOG4108MEK Metal-binding protein YodA CH47_1807 ENOG41090B9 response to stress CH47_1808 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CH47_1809 ENOG4105CZE histidine utilization repressor CH47_1810 ENOG4105CI2 imidazolone-5-propionate hydrolase CH47_1813 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) CH47_1814 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) CH47_1816 ENOG4105F4X arginine CH47_1817 ENOG4105C8Y Acetylornithine aminotransferase CH47_1818 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH47_1819 ENOG4105C4M (Ubiquinol oxidase) subunit I CH47_182 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein CH47_1820 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CH47_1821 ENOG4105BZU Histidine kinase CH47_1822 ENOG4107R11 Transcriptional regulator CH47_1823 ENOG4105F27 Major Facilitator CH47_1825 ENOG4105EWV Sodium calcium exchanger membrane region CH47_1826 ENOG4105D5M phosphate starvation-inducible protein CH47_1828 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD CH47_1829 ENOG4105CND Glycosyl transferase, family 2 CH47_183 ENOG4105BZU Histidine kinase CH47_1830 ENOG4107BJW polysaccharide deacetylase CH47_1831 ENOG4108TUY outer membrane protein PgaA CH47_1832 ENOG4105H1N peptidase, M24 CH47_1833 ENOG4108819 ferric iron reductase CH47_1834 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CH47_1835 ENOG4105EXG Transcriptional regulator CH47_1839 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH47_184 ENOG4105F7P transcriptional regulator AsnC family CH47_1841 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH47_1844 ENOG4107SJW iron permease, FTR1 CH47_1847 ENOG4105CSV Glutaminase CH47_1848 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CH47_1849 ENOG4105FB2 class II Aldolase CH47_1850 ENOG4105G63 Type III effector Hrp-dependent CH47_1851 ENOG4105MVE transcriptional regulator CH47_1852 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CH47_1853 ENOG4108MRH transcriptional regulatory protein CH47_1855 ENOG4105C85 amino acid CH47_1859 ENOG4106UW1 Major Facilitator superfamily CH47_1860 ENOG4108HCJ Hydrolase CH47_1861 ENOG4105CDA abc transporter atp-binding protein CH47_1862 ENOG4105E5Q amino acid AbC transporter CH47_1863 ENOG4105EAB amino acid AbC transporter CH47_1864 ENOG4105K6H D-cysteine desulfhydrase CH47_1865 ENOG4108M9K flagella biosynthesis protein FliZ CH47_1866 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH47_1867 ENOG4108C80 FliB family CH47_1868 ENOG4105I03 Flagellin CH47_1869 ENOG4105I03 Flagellin CH47_187 ENOG4105DPW Major facilitator superfamily MFS_1 CH47_1870 ENOG4105I03 Flagellin CH47_1871 ENOG4105DTS flagellar hook-associated CH47_1872 ENOG4105MQ3 flagellar protein FliS CH47_1873 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) CH47_1875 ENOG4105DHT Metal Dependent Phosphohydrolase CH47_1879 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CH47_188 ENOG4107P2S Transcriptional regulator CH47_1880 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CH47_1881 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CH47_1882 ENOG41090PJ Flagellar assembly protein CH47_1883 ENOG4108JIR Flagellum-specific ATP synthase CH47_1884 ENOG4105GSA Flagellar export protein flij CH47_1885 ENOG4105WF4 Flagellar hook-length control protein CH47_1886 ENOG4107ZI8 flagellar basal body-associated protein flil CH47_1887 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CH47_1888 ENOG4105DD5 Flagellar motor switch protein CH47_189 ENOG4105DVC DnaJ domain protein CH47_1890 ENOG4105CN7 Flagellar biosynthetic protein FliP CH47_1891 ENOG4105VS8 Flagellar biosynthetic protein fliq CH47_1892 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CH47_1893 ENOG4105DTJ flagellar hook-associated protein CH47_1894 ENOG4105E1Q flagellar hook-associated protein CH47_1895 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CH47_1898 ENOG4105CGA flagellar basal-body rod protein FlgG CH47_1899 ENOG4108KPB Flagellar basal-body rod protein FlgF CH47_1900 ENOG4105BZE flagellar hook protein, FlgE CH47_1901 ENOG4105W00 Flagellar hook capping protein CH47_1902 ENOG4108ZC9 flagellar basal-body rod protein flgc CH47_1903 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CH47_1904 ENOG4105CKS Flagella basal body P-ring formation protein flgA CH47_1905 ENOG4105M9M anti-sigma28 factor FlgM CH47_1906 ENOG4105QVD Flagella synthesis protein FlgN CH47_1907 ENOG4105TNG K13735 adhesin invasin CH47_1908 ENOG4105W13 flagellar protein CH47_1909 ENOG4105D7B Flagellar biosynthesis protein flha CH47_191 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CH47_1910 ENOG4105D00 flagellar biosynthetic protein flhB CH47_1911 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin CH47_1912 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) CH47_1913 ENOG4108VYJ response regulator receiver protein CH47_1915 ENOG4105BZU Histidine kinase CH47_1916 ENOG4105C8Q Methyl-accepting chemotaxis CH47_1917 ENOG4105C8Q Methyl-accepting chemotaxis CH47_1918 ENOG4108V3W Chemotaxis protein, CheW CH47_1919 ENOG4105CBS Chea signal transduction histidine kinase CH47_192 ENOG4105KVH Transcriptional regulator CH47_1920 ENOG4105ER2 Ompa motb domain protein CH47_1921 ENOG4107RD7 Flagellar Motor Protein, MotA CH47_1922 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region CH47_1923 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) CH47_1924 ENOG4108VA4 Universal stress protein CH47_1925 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CH47_1926 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CH47_1927 ENOG4105KT7 mgtC SapB transporter CH47_1929 ENOG4105C8Q Methyl-accepting chemotaxis CH47_193 ENOG4107B2H carbonic anhydrase CH47_1930 ENOG4105VZF DsrB protein CH47_1932 ENOG4105VEQ Cold shock protein CH47_1933 ENOG4105ETE Transcriptional regulator (LacI family CH47_1934 ENOG4105CNT hydrolase family 2 CH47_1935 ENOG4105VNT transposase (IS4 family) protein CH47_1936 ENOG4105VNT transposase (IS4 family) protein CH47_1938 ENOG4105GSJ Inner membrane protein ylaC CH47_1941 ENOG41061EV selenium-binding protein YdfZ CH47_1942 ENOG4105D6F Phosphatase CH47_1943 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CH47_1945 ENOG4108S1B Periplasmic chaperone protein CH47_1947 ENOG4105CMG Carbohydrate kinase CH47_1948 ENOG4108M3J Dehydrogenase CH47_1949 ENOG4105D7K pfkb domain protein CH47_1950 ENOG4105CNN ABC, transporter CH47_1952 ENOG4105C2J ABC transporter CH47_1954 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) CH47_1959 ENOG4105EYM Major Facilitator superfamily CH47_1960 ENOG4105BZ1 (ABC) transporter CH47_1963 ENOG4105C0W non-ribosomal peptide synthetase CH47_1967 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CH47_1969 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_197 ENOG4107QHF type ii secretion system protein e CH47_1973 ENOG4105CMM transposase CH47_1975 ENOG4105CMM transposase CH47_198 ENOG4105D7Q type ii secretion system CH47_1982 ENOG4105D3G Pseudouridine synthase CH47_1983 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CH47_1984 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CH47_1985 ENOG4105C54 Major Facilitator superfamily CH47_1987 ENOG4108TSE Transferase CH47_1988 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CH47_199 ENOG4108VAU general secretion pathway protein G CH47_1990 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CH47_1991 ENOG4107QPK )-transporter CH47_1992 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CH47_1993 ENOG4105YGP holo-ACP synthase CitX CH47_1994 ENOG4105CHY citrate lyase, alpha CH47_1995 ENOG4105CI0 Citrate lyase CH47_1996 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) CH47_1997 ENOG4105DUA (citrate (pro-3S)-lyase ligase CH47_1998 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CH47_1999 ENOG4106YYS transcriptional regulatory protein CH47_2 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit CH47_20 ENOG4105EAM Na Pi-cotransporter CH47_2000 ENOG4108KX4 response regulator CH47_2001 ENOG4105BZU Histidine kinase CH47_2002 ENOG4105CXY transporter CH47_2003 ENOG4105C4Y ABC transporter CH47_2004 ENOG4107RCV ABC transporter, permease CH47_2005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH47_2007 ENOG4108Q9V regulatoR CH47_2008 ENOG4105BZU Histidine kinase CH47_2013 ENOG4108MQF Chaperone CH47_2020 ENOG4107R88 Chemotaxis protein (CheV) CH47_2021 ENOG4107S1E Beta-lactamase CH47_2022 ENOG4105MVE transcriptional regulator CH47_2023 ENOG410667J hydrolase CH47_2024 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CH47_2026 ENOG4105UQX Mate efflux family protein CH47_2027 ENOG4105CDH Citrulline--aspartate ligase CH47_2032 ENOG4105CS6 Rhs element vgr protein CH47_2041 ENOG4105CW0 outer membrane usher protein CH47_2042 ENOG4108VEV chaperone CH47_2043 ENOG4106EAR Fimbrial protein CH47_2044 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH47_205 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) CH47_2054 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CH47_2055 ENOG4108TGR phosphatase CH47_2057 ENOG4108YZT Adenosylcobinamide kinase CH47_2058 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CH47_2060 ENOG4108V4M Cobalt abc transporter CH47_2061 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CH47_2062 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CH47_2063 ENOG4105DVK Precorrin-2 c20-methyltransferase CH47_2064 ENOG4107PPM cobalt chelatase CH47_2065 ENOG4105QUC reductase CH47_2066 ENOG4105E4R Precorrin-3B C17-methyltransferase CH47_2067 ENOG4108P62 biosynthesis protein (CbiG) CH47_2068 ENOG4105CIA precorrin-4 C(11)-methyltransferase CH47_2069 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase CH47_2070 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase CH47_2071 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CH47_2072 ENOG41081F0 Precorrin-8x methylmutase CH47_2073 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CH47_2074 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CH47_2075 ENOG4107XVH Transcriptional regulator CH47_2076 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CH47_2077 ENOG4105KNY Microcompartments protein CH47_2078 ENOG4105EHR propanediol utilization protein pduB CH47_2079 ENOG4105DMB glycerol dehydratase CH47_208 ENOG4105C8Q Methyl-accepting chemotaxis CH47_2080 ENOG4105YCI dehydratase medium subunit CH47_2081 ENOG4108ZFT Dehydratase small subunit CH47_2082 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit CH47_2084 ENOG4105KNY Microcompartments protein CH47_2086 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) CH47_2088 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml CH47_2090 ENOG4108EKI Dehydrogenase CH47_2092 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CH47_2094 ENOG4105M3W utilization protein CH47_2095 ENOG4105KTW ethanolamine utilization protein CH47_2096 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CH47_2097 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH47_2098 ENOG4107QZB decarboxylase CH47_2099 ENOG4105JZC GHMP kinase CH47_2100 ENOG4105VJY transcriptional regulator CH47_2102 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CH47_2103 ENOG4105C2J ABC transporter CH47_2104 ENOG4105CNN ABC, transporter CH47_2106 ENOG41090HJ UPF0265 protein CH47_2107 ENOG4105DR8 Membrane CH47_2108 ENOG4105E4E Thioester reductase domain-containing protein CH47_2109 ENOG4105CJB Exodeoxyribonuclease I CH47_211 ENOG4105EJC lysr family transcriptional regulator CH47_2110 ENOG4105CUB amino acid CH47_2112 ENOG4107SCQ Iron-containing alcohol dehydrogenase CH47_2113 ENOG4105C2J ABC transporter CH47_2114 ENOG4105CNN ABC, transporter CH47_2115 ENOG4108535 NAD dependent epimerase/dehydratase family CH47_2116 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CH47_2118 ENOG4105CIH Imidazole acetol-phosphate transaminase CH47_2119 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CH47_212 ENOG4105RQF LysR family Transcriptional regulator CH47_2120 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CH47_2121 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CH47_2122 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CH47_2123 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CH47_2124 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CH47_2127 ENOG4105VNT transposase (IS4 family) protein CH47_2128 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CH47_2129 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CH47_213 ENOG4105F27 Major Facilitator CH47_2130 ENOG4105EE5 Membrane protein terC CH47_2131 ENOG4105CEE C4-dicarboxylate transporter CH47_2132 ENOG4108GAE asmA family CH47_2133 ENOG4105DHP deoxycytidine triphosphate deaminase CH47_2134 ENOG4105DBI uridine monophosphokinase CH47_2135 ENOG4105D1F ATP-binding protein CH47_2136 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CH47_214 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CH47_2140 ENOG4105E5W Transporter CH47_2141 ENOG4105VAW lrga family CH47_2142 ENOG41067MG lrgb family CH47_2145 ENOG4107R1I NAD-dependent malic enzyme CH47_2146 ENOG4107GZ4 SanA protein CH47_2148 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CH47_2149 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) CH47_215 ENOG41060NJ transcriptional regulator CH47_2150 ENOG4108JPZ Monovalent cation H antiporter subunit D CH47_2151 ENOG4107TDF Formate hydrogenlyase subunit 4 CH47_2152 ENOG4105D65 subunit l CH47_2153 ENOG4107WQX hydrogenase 4 membrane subunit CH47_2154 ENOG4108JPZ Monovalent cation H antiporter subunit D CH47_2155 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH47_2157 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit CH47_2158 ENOG4105I6X formate hydrogenlyase maturation CH47_2159 ENOG4108MG9 hydrogenase 3 maturation protease CH47_2160 ENOG4108RC0 Electron transport protein CH47_2161 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH47_2162 ENOG4108JUA Transcriptional regulator CH47_2163 ENOG4105TMB Formate nitrite transporter CH47_2164 ENOG4107SDZ Galactoside transport system permease protein mglC CH47_2167 ENOG41060NJ transcriptional regulator CH47_2168 ENOG4105DHF Membrane CH47_2169 ENOG4105EUJ GTP cyclohydrolase i CH47_217 ENOG4105CEY Amp-dependent synthetase and ligase CH47_2170 ENOG4105CBP Major Facilitator CH47_2171 ENOG4105EGI Transcriptional regulator CH47_2174 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_2178 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CH47_218 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) CH47_2181 ENOG4105CVM Molybdenum cofactor synthesis domain protein CH47_2182 ENOG4105D06 uba thif-type nad fad binding protein CH47_2183 ENOG4108M1A Chitin-binding protein CH47_2184 ENOG4105C5H ABC transporter CH47_2188 ENOG4108T1M outer membrane protein x CH47_219 ENOG4105CPC Aldo Keto reductase CH47_2194 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CH47_2195 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CH47_2196 ENOG4105KSC Transcriptional regulator, TraR DksA family CH47_2197 ENOG4107R0W ABC transporter CH47_2198 ENOG4105E5Q amino acid AbC transporter CH47_2199 ENOG4105CDA abc transporter atp-binding protein CH47_22 ENOG4105ETE Transcriptional regulator (LacI family CH47_220 ENOG4105EE5 Membrane protein terC CH47_2200 ENOG4107SDU Methyl-accepting chemotaxis CH47_2201 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) CH47_2204 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction CH47_2206 ENOG4108MTB glycosyl transferase family CH47_2207 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CH47_2208 ENOG4105DVT helicase CH47_221 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) CH47_2211 ENOG4105FDR Membrane CH47_2212 ENOG4105HEI LysR family (Transcriptional regulator CH47_2215 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component CH47_2216 ENOG4108IJ8 ABC transporter CH47_2217 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component CH47_2218 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CH47_222 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CH47_2220 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CH47_2221 ENOG4105KHC sulfurtransferase CH47_2222 ENOG4108IV0 ABC, transporter CH47_2223 ENOG4105D5T phosphonate abc transporter CH47_2224 ENOG4105CNN ABC, transporter CH47_2225 ENOG4105C32 Amino acid ABC transporter (Permease) CH47_2227 ENOG4108W15 Protein of unknown function (DUF1456) CH47_223 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CH47_2230 ENOG4105EHI Phosphonate ABC transporter, periplasmic CH47_2232 ENOG4105Y3U Transglycosylase-associated protein CH47_2234 ENOG4105N1F Hnh endonuclease CH47_2236 ENOG4105CXG d-lactate dehydrogenase CH47_2237 ENOG41061WM D-Alanyl-D-Alanine CH47_224 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CH47_2240 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CH47_2243 ENOG4105C1J atp-dependent rna helicase CH47_2244 ENOG4107MVR Transcriptional regulator CH47_2245 ENOG4105D0S secretion protein (HlyD CH47_2246 ENOG4105CJ1 ABC, transporter CH47_2247 ENOG4107QWP ABC-2 type transporter CH47_2248 ENOG4107QWP ABC-2 type transporter CH47_2249 ENOG4105HFZ Membrane CH47_225 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CH47_2250 ENOG4108ZAF Molybdopterin CH47_2251 ENOG4105M00 molybdopterin converting factor, subunit 1 CH47_2252 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CH47_2253 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CH47_2254 ENOG4105CHW UPF0052 protein CH47_2255 ENOG4105VYA Uncharacterized conserved protein (DUF2132) CH47_2256 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CH47_2258 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CH47_2259 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CH47_2260 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CH47_2261 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CH47_2263 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CH47_2264 ENOG4108K4B hydrolase CH47_2266 ENOG4105E0C molybdate abc transporter CH47_2267 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CH47_2268 ENOG410680R Protein of unknown function (DUF2592) CH47_2269 ENOG4105F4R Transcriptional regulator mode CH47_2270 ENOG4105DKW ABC transporter CH47_2272 ENOG4105CMR udp-glucose 4-epimerase CH47_2273 ENOG4105F0Z galactose-1-phosphate uridylyltransferase CH47_2274 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CH47_2275 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CH47_2280 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CH47_2281 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH47_2282 ENOG4105PGM cation diffusion facilitator family transporter CH47_2283 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CH47_2284 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CH47_2289 ENOG4105UFD tol-pal system protein YbgF CH47_2290 ENOG4105KCK Peptidoglycan-associated lipoprotein CH47_2291 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CH47_2292 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CH47_2292 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA CH47_2293 ENOG4105M8F Biopolymer transport protein exbD tolR CH47_2294 ENOG4105E02 MotA TolQ exbB proton channel CH47_2295 ENOG4107YD3 Thioesterase CH47_2296 ENOG4105KJB cyd operon protein YbgE CH47_2298 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CH47_2299 ENOG4105C4M (Ubiquinol oxidase) subunit I CH47_230 ENOG4105DSY exodeoxyribonuclease V, gamma CH47_2300 ENOG4105CGH 5'-nucleotidase CH47_2301 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CH47_2302 ENOG4105CMV Succinyl-CoA synthetase subunit beta CH47_2303 ENOG4105C7S Dehydrogenase CH47_2304 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CH47_2305 ENOG4105E33 succinate dehydrogenase CH47_2307 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CH47_2308 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CH47_2309 ENOG4105BZN citrate synthase CH47_231 ENOG4107QXK peptidase CH47_2310 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CH47_2313 ENOG4105E7W lamb ycsf family protein CH47_2314 ENOG4107R7A Allophanate hydrolase subunit 2 CH47_2315 ENOG4105P4J Allophanate hydrolase, subunit 1 CH47_2316 ENOG4107QNR UPF0135 protein CH47_2317 ENOG4107RF4 Phosphodiesterase CH47_2318 ENOG4105CVP deoxyribo-dipyrimidine photolyase CH47_2319 ENOG4107SEY Conserved Protein CH47_232 ENOG4107QKA exodeoxyribonuclease V beta CH47_2320 ENOG4105XIQ Protein of unknown function (DUF2517) CH47_2321 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CH47_2322 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CH47_2323 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CH47_2324 ENOG4105C08 Histidine kinase CH47_2325 ENOG4105EEX Two component transcriptional regulator (Winged helix family CH47_2328 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CH47_233 ENOG4107QYX exodeoxyribonuclease v alpha CH47_2330 ENOG4105EV9 Alpha Beta Hydrolase CH47_2332 ENOG4105NNH LexA regulated protein CH47_2333 ENOG4105C8Q Methyl-accepting chemotaxis CH47_2334 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) CH47_2335 ENOG41090R7 Ferric uptake CH47_2337 ENOG4105GX6 (LipO)protein CH47_2339 ENOG4105CX6 glutaminyL-tRNA synthetase CH47_234 ENOG4107QZM n-acetylglutamate synthase CH47_2340 ENOG4105CI1 PTS System CH47_2341 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CH47_2342 ENOG4105CE4 GlcNAc 6-P deacetylase CH47_2343 ENOG4105E2R ROK family CH47_2344 ENOG4105D4U had-superfamily hydrolase, subfamily iia CH47_2345 ENOG4105CAQ asparagine synthetase CH47_235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CH47_2352 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CH47_2353 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CH47_2354 ENOG4105C9A Phoh family CH47_2355 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CH47_2356 ENOG4108JU5 Magnesium and cobalt efflux protein CH47_2357 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CH47_2359 ENOG4107RP9 extracellular solute-binding protein, family 3 CH47_2360 ENOG4105EAD ABC transporter CH47_2361 ENOG4105DRP amino acid AbC transporter CH47_2362 ENOG4105CDA abc transporter atp-binding protein CH47_2363 ENOG4107PAI alpha helical protein CH47_2364 ENOG4105C8T Leucyl-tRNA synthetase CH47_2365 ENOG4108U2H Rare lipoprotein B CH47_2366 ENOG4105DJF DNA polymerase III, delta' subunit CH47_2367 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CH47_2368 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CH47_2370 ENOG4105CJN penicillin-binding protein CH47_2371 ENOG4105CNI cell division protein FtsW CH47_2372 ENOG4105K6T rare lipoprotein A CH47_2373 ENOG4105DZ1 carboxypeptidase CH47_2374 ENOG4108Z43 UPF0250 protein CH47_2375 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CH47_2376 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CH47_2377 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) CH47_2378 ENOG4105BZU Histidine kinase CH47_2379 ENOG4107Z6W Protein CrcB homolog CH47_2380 ENOG4105VEQ Cold shock protein CH47_2382 ENOG4108N8T regulatoR CH47_2384 ENOG4108R1E Serine threonine protein phosphatase 1 CH47_2387 ENOG4108JJ7 ABC transporter CH47_2389 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CH47_2390 ENOG4105C84 Histidine ammonia-lyase CH47_2391 ENOG4105EZE Cupin 4 family protein CH47_2392 ENOG4105ENX hydrolase CH47_2394 ENOG4105GR3 Histidine kinase CH47_240 ENOG4105CA3 membrane-bound lytic murein transglycosylase CH47_2401 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH47_2406 ENOG41090WB Transposase is3 is911 CH47_241 ENOG4105CUZ uba thif-type nad fad binding protein CH47_2410 ENOG4108X9F tail fiber protein CH47_2411 ENOG4105K64 Glycosyl transferase, family 2 CH47_2412 ENOG4105UZW Tail fiber assembly protein CH47_2413 ENOG410685N tail fiber protein CH47_2416 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_242 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CH47_2420 ENOG4108KU3 Integrase CH47_2422 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CH47_2423 ENOG4105WQ3 Rna-binding protein CH47_2424 ENOG4105C8N cysteinyl-tRNA synthetase CH47_2425 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH47_2426 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CH47_2427 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CH47_2428 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CH47_2429 ENOG4105CV6 ABC transporter, permease CH47_243 ENOG4105C9B Cysteine desulfurase CH47_2430 ENOG4108I0Y (ABC) transporter CH47_2431 ENOG4108UJV acyl-CoA thioesterase i CH47_2432 ENOG4105E1F short-chain dehydrogenase reductase CH47_2433 ENOG4107QR8 Thioredoxin CH47_2434 ENOG4107QX8 SPFH domain, Band 7 family protein CH47_2435 ENOG4105G5H Membrane CH47_2436 ENOG4108Z6Z Transcriptional regulator CH47_2437 ENOG4105C59 p-type ATPase CH47_2438 ENOG4105MBR gumn family CH47_2439 ENOG4108Z66 YbaK ebsC protein CH47_244 ENOG4105M5B (LipO)protein CH47_2441 ENOG4105CGH 5'-nucleotidase CH47_2442 ENOG4105EU0 Major facilitator Superfamily CH47_2443 ENOG4105CKD glutathione-regulated potassium-efflux system protein CH47_2444 ENOG4107RE1 Inosine-guanosine kinase CH47_2446 ENOG4105CMR udp-glucose 4-epimerase CH47_2447 ENOG4107QKV phosphomannomutase CH47_2448 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CH47_2449 ENOG4105C30 Nad-dependent epimerase dehydratase CH47_245 ENOG4105ETT transcriptional Regulator, LysR family CH47_2450 ENOG4105C0K Gdp-mannose 4,6-dehydratase CH47_2451 ENOG4108KMV Glycosyl transferase (Group 1 CH47_2453 ENOG4107S6X Glycosyl transferase, family 2 CH47_2456 ENOG4107YYJ Glycosyl transferase, family 2 CH47_2458 ENOG4107YYJ Glycosyl transferase, family 2 CH47_2459 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CH47_246 ENOG4105M08 Membrane CH47_2460 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CH47_2461 ENOG4105FAW cDP-glucose 4,6-dehydratase CH47_2462 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CH47_2463 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CH47_2464 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CH47_2465 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CH47_2466 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CH47_2467 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CH47_2468 ENOG4107QMP dna polymerase iii subunits gamma and tau CH47_2469 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CH47_247 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) CH47_2470 ENOG4105WD1 Membrane CH47_2472 ENOG4105EGS Mechanosensitive ion channel CH47_2473 ENOG41090EX DsrE family CH47_2474 ENOG4108IG5 Transcriptional regulator CH47_2475 ENOG4105C1P efflux transporter, rnd family, mfp subunit CH47_2476 ENOG4105BZS acriflavin resistance protein CH47_2478 ENOG4108626 Racemase CH47_2479 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CH47_248 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease CH47_2480 ENOG4105MUZ Protein of unknown function DUF2620 CH47_2481 ENOG4106M0N transport system permease protein CH47_2482 ENOG4105NRA 50s ribosomal protein l31 type b CH47_2483 ENOG4105YK5 50S ribosomal protein L36 CH47_2484 ENOG4105DSE periplasmic solute binding protein CH47_2485 ENOG4105CC5 ABC transporter CH47_2486 ENOG4105DIK (ABC) transporter CH47_2489 ENOG4108UKR Biofilm formation regulator YbaJ CH47_249 ENOG4105EWT decarboxylase family CH47_2490 ENOG4105KF5 hemolysin expression-modulating protein CH47_2491 ENOG41080UX Methyltransferase CH47_2492 ENOG4108MNP Glycoprotein polysaccharide metabolism CH47_2493 ENOG4105C29 acyl-CoA thioesterase CH47_2494 ENOG4105BZU Histidine kinase CH47_2495 ENOG4108YZA Nitrogen regulatory protein pii CH47_2496 ENOG4105BZ1 (ABC) transporter CH47_2497 ENOG4105BZ1 (ABC) transporter CH47_2498 ENOG4108XM1 transcriptional regulator AsnC family CH47_250 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CH47_2500 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CH47_2501 ENOG4108NFA extracellular solute-binding protein CH47_2502 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CH47_2503 ENOG4108TGP Thioesterase superfamily protein CH47_2504 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CH47_2505 ENOG4105EIN peptidylprolyl cis-trans isomerase CH47_2507 ENOG4105K70 DNA-binding protein CH47_2508 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CH47_2509 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CH47_251 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) CH47_2510 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CH47_2511 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CH47_2512 ENOG4105M85 Bola protein CH47_2513 ENOG4105IEY (LipO)protein CH47_2514 ENOG4105EYM Major Facilitator superfamily CH47_2515 ENOG4108NFH Sugar hydrolase CH47_2516 ENOG4105E2S oxidase) subunit II CH47_2517 ENOG4105BZ9 Cytochrome C oxidase, subunit I CH47_2518 ENOG4105CCU oxidase (Subunit III) CH47_2519 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CH47_252 ENOG4105WP7 tRNA pseudouridine synthase C CH47_2520 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CH47_2521 ENOG4107RDB Major Facilitator CH47_2522 ENOG4108VPT UPF0234 protein CH47_2523 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CH47_2524 ENOG4107S0N DJ-1 family CH47_2525 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CH47_2527 ENOG4105CTB Polyprenyl synthetase CH47_2528 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CH47_2529 ENOG4108ZAI phosphatidylglycerophosphatase a CH47_253 ENOG4105DR9 pseudouridine synthase CH47_2530 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CH47_2531 ENOG4107YIM Involved in the transcription termination process (By similarity) CH47_2532 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CH47_2533 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CH47_2534 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CH47_2535 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH47_2536 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CH47_2537 ENOG4105VIE preprotein translocase, subunit YajC CH47_2538 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CH47_254 ENOG4105QDK Flavodoxin CH47_2540 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CH47_2541 ENOG4108ZYK Acyl carrier protein phosphodiesterase CH47_2542 ENOG4105D3R alkyl hydroperoxide reductase CH47_2544 ENOG4105CHR reductase CH47_2545 ENOG4107R28 alpha amylase, catalytic region CH47_2546 ENOG4105C85 amino acid CH47_2547 ENOG4105CWM branched-chain amino acid transport system II carrier protein CH47_2549 ENOG4105BZU Histidine kinase CH47_255 ENOG4108T8E UPF0325 protein CH47_2550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CH47_2551 ENOG4107RH8 nuclease SbcCD subunit D CH47_2552 ENOG4105EYH Exonuclease CH47_2553 ENOG4105DKQ ROK family CH47_2554 ENOG4105DH7 May be involved in recombination (By similarity) CH47_2555 ENOG4105NBK UPF0345 protein CH47_2556 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CH47_256 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CH47_2561 ENOG4105F2W methyltransferase CH47_2564 ENOG4105E2V Glycosyltransferase 36 CH47_2567 ENOG4105F8D glycoside hydrolase family 4 CH47_2568 ENOG4105CI1 PTS System CH47_2569 ENOG4105FDP GntR family transcriptional regulator CH47_257 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CH47_2570 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CH47_2571 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CH47_2572 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) CH47_2573 ENOG4105V1F Fermentation respiration switch protein CH47_2574 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CH47_2575 ENOG4105CIN aminoacyl-histidine dipeptidase CH47_2576 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CH47_2579 ENOG4105WWK YheO domain protein CH47_258 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH47_2580 ENOG4105CPF Cell wall formation (By similarity) CH47_2583 ENOG4105CJ2 (LipO)protein CH47_2584 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) CH47_2585 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH47_2586 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH47_2587 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH47_2588 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH47_2589 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) CH47_259 ENOG4105CE9 30S ribosomal protein S2 CH47_2590 ENOG4105E7A Glutamine amidotransferase CH47_2591 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CH47_2592 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CH47_2593 ENOG4107QPN acyl-Coa dehydrogenase CH47_2594 ENOG4106YJS accessory processing protein CH47_2596 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type CH47_2597 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CH47_2598 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CH47_2599 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CH47_260 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CH47_2600 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) CH47_2601 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CH47_2602 ENOG4105CHM Aminotransferase CH47_2604 ENOG4105EQ0 Major Facilitator superfamily CH47_2605 ENOG4108UMN azlc family CH47_2606 ENOG4105ZED uncharacterized protein ygaH CH47_2607 ENOG4105NTK Transcriptional repressor Mpra CH47_2608 ENOG4105ETP RND efflux system, outer membrane lipoprotein CH47_2609 ENOG4105CW7 secretion protein, HlyD family CH47_261 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CH47_2610 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH47_2613 ENOG4105EIB trna rrna methyltransferase CH47_2614 ENOG4105K63 Thioredoxin CH47_2615 ENOG4106IUH DTW domain containing protein CH47_2616 ENOG4105CD5 CoA-binding domain protein CH47_2617 ENOG4105JIM Phosphatidylserine synthase CH47_262 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CH47_2620 ENOG4105DQ6 Transposase CH47_2621 ENOG4105T42 (LipO)protein CH47_2622 ENOG4105VNT transposase (IS4 family) protein CH47_2628 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH47_2629 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CH47_263 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CH47_2630 ENOG4105C34 Pseudouridine synthase CH47_2631 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CH47_2632 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA CH47_2633 ENOG4105CQC Prephenate dehydratase CH47_2634 ENOG4105EHE chorismate mutase- prephenate dehydrogenase CH47_2635 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CH47_2636 ENOG4108NEV two component transcriptional regulator, LytTR family CH47_2637 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CH47_2638 ENOG4108NE3 Salt-induced outer membrane protein CH47_2639 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CH47_264 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CH47_2640 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CH47_2641 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CH47_2642 ENOG4105K5M 30s ribosomal protein S16 CH47_2643 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CH47_2644 ENOG4106KVJ cytochrome C assembly protein CH47_2645 ENOG4108JU6 CBS domain protein CH47_2646 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CH47_2647 ENOG4105D9M gamma-glutamylcysteine synthetase CH47_2648 ENOG4105W39 Membrane CH47_2649 ENOG4107VXZ Hydrolase CH47_265 ENOG4105KNE Phosphatidate cytidylyltransferase CH47_2654 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CH47_2655 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CH47_2656 ENOG4105Y3E Modulates RecA activity (By similarity) CH47_2657 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CH47_266 ENOG4105DZP Membrane-associated zinc metalloprotease CH47_2662 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CH47_2663 ENOG4108IUS Transketolase CH47_2664 ENOG4108HHA Transketolase CH47_2665 ENOG4105CNN ABC, transporter CH47_2666 ENOG4105C2J ABC transporter CH47_2671 ENOG4107GFK fumarate CH47_2672 ENOG4105DKT Transcriptional regulator CH47_2673 ENOG4108XCU pts system CH47_2674 ENOG4105KPI PTS system sorbose subfamily IIB component CH47_2675 ENOG4105ETZ PTS System CH47_2676 ENOG4105F3R pts system mannose fructose sorbose family iid CH47_2677 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein CH47_2678 ENOG4105YVS arsR family transcriptional regulator CH47_2679 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CH47_268 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) CH47_2681 ENOG4105EIG urea carboxylase-associated protein 1 CH47_2682 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CH47_2683 ENOG4105CDA abc transporter atp-binding protein CH47_2684 ENOG4105E5Q amino acid AbC transporter CH47_2685 ENOG4105E5Q amino acid AbC transporter CH47_2686 ENOG4105EAB amino acid AbC transporter CH47_2687 ENOG4105BZC d-serine deaminase CH47_2689 ENOG4105CIH Imidazole acetol-phosphate transaminase CH47_269 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH47_2690 ENOG4105CHR reductase CH47_2693 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH47_2694 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH47_2696 ENOG4105DJY efflux transporter, rnd family, mfp subunit CH47_2697 ENOG4108JJA ABC, transporter CH47_27 ENOG4105CM4 permease protein CH47_270 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CH47_2702 ENOG4105H8W Fimbrial protein CH47_2703 ENOG4105UGQ Fimbrial CH47_2705 ENOG4108FZ9 Chaperone CH47_2706 ENOG4106PG1 outer membrane usher protein CH47_271 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH47_2712 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CH47_2713 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH47_2714 ENOG4108K5P (LipO)protein CH47_2715 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CH47_2716 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CH47_2717 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) CH47_2718 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CH47_272 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CH47_2720 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CH47_2721 ENOG4105N0Z inner membrane protein ygbE CH47_2722 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CH47_2723 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CH47_2724 ENOG4105C11 sulfate adenylyltransferase), subunit 2 CH47_2725 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH47_2726 ENOG4108MXK alkaline phosphatase isozyme conversion CH47_2729 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CH47_273 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CH47_2730 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CH47_2731 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CH47_2732 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CH47_2733 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CH47_2736 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_2738 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CH47_2739 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CH47_274 ENOG4105C0B DNA polymerase III (alpha subunit) CH47_2740 ENOG4105DXN mazG family CH47_2741 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH47_2742 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CH47_2743 ENOG4105BZU Histidine kinase CH47_2744 ENOG4105C0H protease CH47_2745 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CH47_2746 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CH47_2748 ENOG4105EN6 Membrane CH47_2749 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CH47_275 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CH47_2751 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CH47_2752 ENOG4105DQQ Major facilitator superfamily MFS_1 CH47_2753 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_2754 ENOG4105S6R Iron-hydroxamate transporter permease subunit CH47_2755 ENOG4105J76 Periplasmic binding protein CH47_2756 ENOG4105E0A ABC, transporter CH47_2757 ENOG4105BZ4 penicillin-binding protein CH47_2758 ENOG4105CQ7 ATP-dependent helicase CH47_2759 ENOG4107XID 2'-5' rna ligase CH47_276 ENOG4105CXN decarboxylase CH47_2760 ENOG4105PW4 Sugar fermentation stimulation protein homolog CH47_2761 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CH47_2763 ENOG4105DJ0 Poly(A) Polymerase CH47_2764 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CH47_2765 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CH47_2766 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CH47_2767 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CH47_2768 ENOG4107BJW polysaccharide deacetylase CH47_2769 ENOG4105E3A (ABC) transporter CH47_277 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CH47_2770 ENOG4105DA5 (ABC) transporter CH47_2771 ENOG41077A9 carbonic anhydrase CH47_2772 ENOG4108UGV hypoxanthine phosphoribosyltransferase CH47_2773 ENOG4105E3B Multicopper oxidase CH47_2774 ENOG4108ZRK uncharacterized protein yacC CH47_2775 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CH47_2776 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CH47_2778 ENOG4105RPH Inner membrane protein YddG CH47_2779 ENOG4108ZIG UPF0231 protein CH47_278 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CH47_2780 ENOG4107QIJ Aconitate hydratase 2 CH47_2781 ENOG4107RNH Outer membrane receptor FepA CH47_2783 ENOG4107QN2 dihydrolipoyl dehydrogenase CH47_2784 ENOG4107QSN dihydrolipoamide acetyltransferase CH47_2785 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CH47_2786 ENOG41073TP transcriptional regulator CH47_2787 ENOG4105C85 amino acid CH47_2789 ENOG4106A72 regulatory protein AmpE CH47_279 ENOG4105N7H Cytochrome CH47_2791 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CH47_2792 ENOG4108ZUW Major pilin subunit CH47_2793 ENOG4107QHF type ii secretion system protein e CH47_2794 ENOG4105D7Q type ii secretion system CH47_2795 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CH47_2796 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CH47_2797 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) CH47_2798 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CH47_2799 ENOG4105M6F mutator MutT protein CH47_28 ENOG4108IPW abc transporter atp-binding protein CH47_280 ENOG4105M1T rho-binding antiterminator CH47_2800 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CH47_2801 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) CH47_2804 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CH47_2805 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CH47_2806 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CH47_2808 ENOG4105DFU Cell wall formation (By similarity) CH47_2809 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CH47_281 ENOG4105W1I UPF0253 protein CH47_2810 ENOG4105CNI cell division protein FtsW CH47_2812 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CH47_2813 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CH47_2814 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CH47_2815 ENOG4105CJN penicillin-binding protein CH47_2816 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CH47_2817 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CH47_2818 ENOG4108V6E Cell division protein mraZ CH47_282 ENOG4108VWS Yaeq family CH47_2820 ENOG4107B7Y DNA-binding transcriptional regulator FruR CH47_2821 ENOG4108ZP8 Acetolactate synthase small subunit CH47_2822 ENOG4105C7K acetolactate synthase CH47_2823 ENOG4108IQE Amp-dependent synthetase and ligase CH47_2825 ENOG41064T2 transcriptional regulator, lysR family CH47_2826 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CH47_2827 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CH47_2828 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CH47_283 ENOG4108YZN class I peptide chain release factor CH47_2831 ENOG4105C0F tryptophanase EC 4.1.99.1 CH47_2832 ENOG4105CIC tryptophan-specific transport protein CH47_2833 ENOG4105S8Q sugar efflux transporter CH47_2836 ENOG4105C6N Formate acetyltransferase CH47_2837 ENOG4105F1A Pyruvate formate-lyase CH47_2838 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CH47_284 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion CH47_2841 ENOG4105DP9 ABC transporter CH47_2842 ENOG4106SMU thiamine transporter membrane protein CH47_2843 ENOG4108KF1 Membrane CH47_2845 ENOG4105CQ2 DNA polymerase CH47_2846 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CH47_2847 ENOG4105D3G Pseudouridine synthase CH47_2848 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CH47_2849 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CH47_285 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CH47_2850 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CH47_2851 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CH47_2852 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CH47_2853 ENOG4105NWN ApaG protein CH47_2854 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CH47_2855 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CH47_2856 ENOG4107XM3 UPF0442 protein CH47_2857 ENOG4105DWK Membrane CH47_2858 ENOG4105N14 lysine exporter protein LysE YggA CH47_2859 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CH47_286 ENOG4108R96 Methyltransferase, YaeB family CH47_2860 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CH47_2861 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CH47_2862 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CH47_2863 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CH47_2864 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CH47_2865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CH47_2866 ENOG4105DTN riboflavin biosynthesis protein ribF CH47_2867 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CH47_2868 ENOG41063Z6 transcriptional regulator, lysR family CH47_2869 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CH47_287 ENOG4108R8X outer membrane lipoprotein CH47_2870 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CH47_2872 ENOG4106HK8 GPR1 FUN34 yaaH family protein CH47_2875 ENOG4108RIR Molybdenum cofactor biosynthesis protein CH47_2876 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CH47_2877 ENOG4105D1Q UPF0246 protein CH47_2879 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CH47_288 ENOG4105D01 (LipO)protein CH47_2881 ENOG41065U4 response regulator CH47_2882 ENOG4108RH0 Crea protein CH47_2883 ENOG4105CVJ phosphoglycerate mutase CH47_2884 ENOG4105UEI Transcriptional Regulator AraC Family CH47_2885 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CH47_2886 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) CH47_2887 ENOG4107SC1 transglycosylase CH47_289 ENOG4108UMI ABC transporter, permease CH47_2890 ENOG4108KHX Diguanylate cyclase CH47_2891 ENOG41090EK ompa motb domain protein CH47_2892 ENOG4105C5H ABC transporter CH47_2895 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase CH47_2896 ENOG4105CIS alcohol dehydrogenase CH47_2897 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CH47_2898 ENOG4105EAC phosphoserine phosphatase CH47_2899 ENOG41062Z9 Membrane CH47_29 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CH47_2900 ENOG4105EUP HipA domain protein CH47_2901 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CH47_2902 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CH47_2903 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CH47_2904 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CH47_2905 ENOG4105D9N nucleoside CH47_2906 ENOG4105EYA deoxyribonuclease CH47_2907 ENOG4108NRW Phospholipase, patatin family CH47_2909 ENOG4105K3G Periplasmic Protein CH47_291 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CH47_2910 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CH47_2911 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CH47_2912 ENOG4108WPU DNA polymerase III subunit psi CH47_2913 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CH47_2914 ENOG4105CPC Aldo Keto reductase CH47_2915 ENOG4105CBN LysR family transcriptional regulator CH47_2918 ENOG4105YBH Protein of unknown function (DUF1435) CH47_2919 ENOG4105BZU Histidine kinase CH47_2920 ENOG4105GAV receptor CH47_2922 ENOG4105D7K pfkb domain protein CH47_2925 ENOG4108HKT sucrose-6-phosphate hydrolase CH47_2926 ENOG4105WBN Transcriptional regulator (LacI family CH47_2927 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CH47_2935 ENOG4105VDH Dihydroxyacetone kinase CH47_2936 ENOG4108UTZ Dihydroxyacetone kinase CH47_2937 ENOG4105CMT Dihydroxyacetone kinase CH47_2939 ENOG4105VNT transposase (IS4 family) protein CH47_2940 ENOG4105BZS acriflavin resistance protein CH47_2941 ENOG410624X efflux transporter, rnd family, mfp subunit CH47_2942 ENOG4105CEU Arginine dihydrolase CH47_2943 ENOG4105D5Q Arginine ornithine antiporter CH47_2945 ENOG4105DKP glycosyl transferase, family 9 CH47_2946 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CH47_2947 ENOG4105DKT Transcriptional regulator CH47_2948 ENOG4105C2J ABC transporter CH47_2949 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CH47_2950 ENOG4105F5R ABC transporter CH47_2951 ENOG4105D4B ABC, transporter CH47_2952 ENOG41061GT Aldolase CH47_2953 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound CH47_2955 ENOG4105RI1 glycoprotein receptor CH47_2967 ENOG4105VEV -acetyltransferase CH47_2976 ENOG4108K5H permease YjgP YjgQ family protein CH47_2977 ENOG4108M8S permease YjgP YjgQ family protein CH47_2978 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CH47_2979 ENOG4105MYG DNA polymerase iii, chi subunit CH47_2981 ENOG4108MJ3 acetyltransferase CH47_2982 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) CH47_2984 ENOG4105XEP YhcH YjgK YiaL family protein CH47_2986 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH47_2987 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH47_2988 ENOG4105C3U ABC transporter CH47_2989 ENOG4108JQ7 (ABC) transporter CH47_2992 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CH47_2993 ENOG410642W LysR family Transcriptional regulator CH47_2994 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CH47_2995 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CH47_2998 ENOG4107RJJ Transcriptional regulator CH47_2999 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG CH47_3 ENOG4105DPX Hydrogenase, large subunit CH47_3000 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH CH47_3001 ENOG4105EKV Phosphonate metabolism protein CH47_3002 ENOG4105FT8 Phosphonate metabolism CH47_3003 ENOG4105ENV phosphonate C-P lyase system protein PhnK CH47_3004 ENOG4105HRV phosphonate c-p lyase system protein phnl CH47_3005 ENOG4105FD8 phosphonate metabolism protein PhnM CH47_3006 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) CH47_3007 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein CH47_3008 ENOG4105K4T epimerase CH47_3010 ENOG4108ZPB UPF0306 protein CH47_3013 ENOG4105DRS transport system, permease CH47_3014 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CH47_3017 ENOG4105EY3 heparinase II III family protein CH47_3018 ENOG4105CXN decarboxylase CH47_3019 ENOG4105D5Q Arginine ornithine antiporter CH47_3020 ENOG4108YYD acetyltransferase CH47_3021 ENOG41082IR Excinuclease ABC C subunit domain protein CH47_3022 ENOG4105XPQ lipid carrier protein CH47_3023 ENOG4105CFP Peptidase U32 CH47_3024 ENOG4106RZ4 Peptidase U32 CH47_3025 ENOG4105CEM UPF0597 protein CH47_3026 ENOG4105C44 Serine transporter CH47_3027 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CH47_3028 ENOG4105BZS acriflavin resistance protein CH47_3029 ENOG4105C1P efflux transporter, rnd family, mfp subunit CH47_3030 ENOG4105DEN Luciferase family CH47_3032 ENOG4105C1J atp-dependent rna helicase CH47_3034 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CH47_3035 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CH47_3036 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CH47_3037 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CH47_3040 ENOG4105CHV Transcription elongation factor NusA CH47_3041 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CH47_3045 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CH47_3046 ENOG4105EEI dihydropteroate synthase CH47_3047 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CH47_3048 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CH47_3049 ENOG4105HBR Rna-binding protein CH47_3050 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CH47_3051 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase CH47_3054 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CH47_3055 ENOG4105QYV Membrane CH47_3056 ENOG4105K46 50S ribosomal protein l27 CH47_3057 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CH47_3058 ENOG4105EAH synthase CH47_306 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CH47_3060 ENOG4105HVQ Regulatory factor of maltose metabolism CH47_3061 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CH47_3062 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) CH47_3064 ENOG4105DFU Cell wall formation (By similarity) CH47_3065 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 CH47_3066 ENOG4105C8Q Methyl-accepting chemotaxis CH47_3067 ENOG4105F0N pyrophosphate phospho-hydrolase CH47_3068 ENOG4108ZHD aig2 family CH47_3070 ENOG4105CFU surface antigen CH47_3071 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CH47_3072 ENOG4105C37 (CBS) domain CH47_3073 ENOG41061GZ Protein of unknown function (DUF1107) CH47_3074 ENOG4108UUE Transcriptional regulator CH47_3075 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CH47_3076 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CH47_3077 ENOG4108V1T peptidylprolyl cis-trans isomerase CH47_3078 ENOG4105FHY Opacity-associated protein A CH47_3080 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CH47_3081 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CH47_3082 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CH47_3084 ENOG4108MXZ Esterase CH47_3085 ENOG4105WSB biofilm stress and motility protein A CH47_3086 ENOG4105CSU acyl-Coa dehydrogenase CH47_3087 ENOG4105C2N RNA methyltransferase TrmH family group 3 CH47_3088 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CH47_3089 ENOG4105KPV Transcriptional regulator CH47_3090 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CH47_3092 ENOG4105EPW hflc protein CH47_3093 ENOG4107QJR hflk protein CH47_3094 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CH47_3095 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CH47_3096 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CH47_3097 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CH47_3098 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CH47_3099 ENOG4105K8N protein family UPF0079, ATPase CH47_31 ENOG4105XJC Two component transcriptional regulator (Winged helix family CH47_3100 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CH47_3101 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CH47_3105 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CH47_3106 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CH47_3107 ENOG4105DJ4 phosphatidylserine decarboxylase CH47_3108 ENOG4105EGS Mechanosensitive ion channel CH47_3109 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CH47_3112 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CH47_3113 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) CH47_3115 ENOG4105KPY Small multidrug resistance protein CH47_3117 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CH47_3118 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CH47_3119 ENOG4108ZVF (LipO)protein CH47_312 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH47_3120 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CH47_3121 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CH47_3124 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CH47_3126 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CH47_3127 ENOG4105BZW Glycerate kinase CH47_3128 ENOG4108SIC Transcriptional regulator CH47_3130 ENOG4108MBX Secretion Protein CH47_3131 ENOG4105EQ2 LysR family Transcriptional regulator CH47_3132 ENOG4107SET aldo keto reductase CH47_3133 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CH47_3135 ENOG4105C6N Formate acetyltransferase CH47_3136 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CH47_3137 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) CH47_3138 ENOG4105C7B Threonine dehydratase CH47_3139 ENOG4105D4P Coproporphyrinogen iii oxidase CH47_314 ENOG4105C2D reductase CH47_3140 ENOG41090JE Utilization Protein CH47_3142 ENOG4107F3C Hemin uptake protein CH47_3143 ENOG4107ENK receptor CH47_3144 ENOG4106QJH hemin transport protein CH47_3145 ENOG4107R4I Periplasmic binding protein CH47_3146 ENOG4105EHG Permease protein CH47_3147 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CH47_3148 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH47_315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH47_3150 ENOG4105E0K tonB-dependent siderophore receptor CH47_3151 ENOG4105EGS Mechanosensitive ion channel CH47_3152 ENOG4105VTW prevent-host-death family CH47_3153 ENOG4107RAN Peptidase, M16 CH47_3154 ENOG4105CQ0 ABC transporter CH47_3155 ENOG4105PE1 Receptor CH47_3156 ENOG4108S3W Anti-feci sigma factor, fecr CH47_3159 ENOG4105KSU Redox protein CH47_316 ENOG4105CV8 reductase CH47_3160 ENOG41066VF YeeE YedE family protein CH47_3163 ENOG4105CK2 sodium dicarboxylate symporter CH47_3164 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CH47_3165 ENOG41062QD Membrane CH47_3166 ENOG4107QN1 sodium solute CH47_317 ENOG4105HEI LysR family (Transcriptional regulator CH47_3174 ENOG4105DC1 bifunctional purine biosynthesis protein purh CH47_3175 ENOG4105C12 Phosphoribosylglycinamide synthetase CH47_3176 ENOG4108T8B Protein of unknown function (DUF1481) CH47_3178 ENOG4105R2J Conserved Protein CH47_3179 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CH47_318 ENOG4105F27 Major Facilitator CH47_3180 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CH47_3181 ENOG4105E09 nadh pyrophosphatase CH47_3182 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor CH47_3183 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CH47_3185 ENOG4105D06 uba thif-type nad fad binding protein CH47_3186 ENOG4105WHD thiamine biosynthesis protein ThiS CH47_3187 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CH47_3188 ENOG4105D41 biosynthesis protein thiH CH47_3189 ENOG4105VNT transposase (IS4 family) protein CH47_319 ENOG4107NA1 Endonuclease Exonuclease phosphatase CH47_3190 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH47_3191 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH47_3192 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CH47_3193 ENOG4108VZM 50s ribosomal protein L10 CH47_3194 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CH47_3195 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CH47_3196 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CH47_3197 ENOG4105PM1 preprotein translocase subunit SecE CH47_3198 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CH47_320 ENOG4105E9H Lytic Murein transglycosylase CH47_3204 ENOG4105CS9 pantothenic acid kinase CH47_3205 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CH47_3207 ENOG4108RS6 transposase CH47_321 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CH47_3213 ENOG4108RR8 protoporphyrinogen oxidase CH47_3214 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CH47_3215 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CH47_3216 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) CH47_3217 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH47_3218 ENOG4105CHU acetyl-coa acetyltransferase CH47_3219 ENOG4107QK7 reductase CH47_322 ENOG4105D1A Methyltransferase CH47_3220 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CH47_3221 ENOG4105MDZ Transcriptional activator rfaH CH47_3222 ENOG4105D52 delta-aminolevulinic acid dehydratase CH47_3224 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CH47_3225 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CH47_3226 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CH47_3227 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CH47_3228 ENOG4105JC1 sterol-binding domain protein CH47_3229 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CH47_323 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CH47_3230 ENOG4105CGY Dna recombination protein CH47_3231 ENOG4108KF1 Membrane CH47_3234 ENOG4108I5U Uridine phosphorylase CH47_3235 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) CH47_3236 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CH47_3237 ENOG4105EMK carboxylate amino acid amine transporter CH47_3238 ENOG4105DZ2 Transcriptional regulator CH47_3239 ENOG4105RK9 auxin efflux carrier CH47_324 ENOG4107RZZ dna polymerase iii epsilon subunit CH47_3240 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CH47_3241 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH47_3242 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CH47_3243 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CH47_3244 ENOG4105BZ7 extracellular solute-binding protein family 1 CH47_3251 ENOG4108IV0 ABC, transporter CH47_3252 ENOG4105C0Z ABC transporter CH47_3253 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CH47_3254 ENOG4105C32 Amino acid ABC transporter (Permease) CH47_3255 ENOG4105CP9 extracellular ligand-binding receptor CH47_3256 ENOG4105U59 -acetyltransferase CH47_3258 ENOG4105CRP Part of the ABC transporter FtsEX involved in CH47_3259 ENOG4105CAK Cell division ATP-binding protein ftsE CH47_326 ENOG4105GIJ Glycine betaine CH47_3260 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CH47_3261 ENOG4106H78 methyltransferase CH47_3262 ENOG4105MG3 Membrane CH47_3265 ENOG4107FS9 Membrane CH47_3266 ENOG4105C59 p-type ATPase CH47_3267 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CH47_3268 ENOG4105EX9 Membrane CH47_3269 ENOG4108W1V Lipoprotein CH47_327 ENOG4108HQS Glycine betaine CH47_3270 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CH47_3271 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B CH47_3272 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CH47_3273 ENOG4105CXY transporter CH47_3274 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CH47_3275 ENOG4105DQF Hydrolase CH47_3276 ENOG4108EUD Lysophospholipase CH47_3277 ENOG410829K Lysine exporter protein (Lyse ygga) CH47_3278 ENOG4105CCF Lysine exporter protein (Lyse ygga) CH47_3279 ENOG4105C9U ATP-dependent DNA helicase RecQ CH47_328 ENOG4108IJ7 Glycine betaine CH47_3280 ENOG4105HDD phospholipase CH47_3281 ENOG4108VUY thioesterase Superfamily protein CH47_3282 ENOG4105FR1 rard protein CH47_3283 ENOG4107QUT magnesium and cobalt transport protein CorA CH47_3285 ENOG4105EQN UPF0261 protein CH47_3287 ENOG4105C4R Atp-dependent dna helicase CH47_3288 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant CH47_3289 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CH47_3290 ENOG4105CT0 Protein of unknown function, DUF484 CH47_3291 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CH47_3292 ENOG4105S7Z (LipO)protein CH47_3293 ENOG4105XQ6 frataxin-like protein CH47_3295 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CH47_3296 ENOG41076E6 Uroporphyrinogen-III Synthase CH47_3297 ENOG4105ECF c-methyltransferase CH47_3298 ENOG410601J HemY protein CH47_330 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH47_3304 ENOG4105C85 amino acid CH47_3307 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) CH47_3308 ENOG4105EGZ biosynthesis protein CH47_3309 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CH47_3310 ENOG4108WJ1 acetyltransferase CH47_3311 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CH47_3312 ENOG4105C1B dTDP-glucose 4-6-dehydratase CH47_3313 ENOG4108IJ1 Dehydrogenase CH47_3314 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CH47_3315 ENOG4105SFE lipopolysaccharide biosynthesis protein CH47_3316 ENOG4105ESV Glycosyl transferase, family 4 CH47_3318 ENOG4105K63 Thioredoxin CH47_332 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CH47_3320 ENOG4105C9X ppx gppa phosphatase CH47_3322 ENOG4105C4R Atp-dependent dna helicase CH47_3323 ENOG4105KQ5 peptidylprolyl cis-trans isomerase CH47_3325 ENOG4105GQR Chaperone CH47_3326 ENOG4105CW0 outer membrane usher protein CH47_3328 ENOG4108VEV chaperone CH47_3329 ENOG41060S4 immunity protein CH47_333 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CH47_3334 ENOG4105VNT transposase (IS4 family) protein CH47_3335 ENOG4105VNT transposase (IS4 family) protein CH47_3336 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CH47_3337 ENOG4105EMY transcriptional regulator CH47_3339 ENOG4105C7B Threonine dehydratase CH47_334 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CH47_3340 ENOG4105C01 Dihydroxy-acid dehydratase CH47_3341 ENOG4105CM2 brancheD-chain amino acid aminotransferase CH47_3342 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit CH47_3344 ENOG4105C0P Mg chelatase subunit ChlI CH47_3345 ENOG4108WFC UPF0438 protein yifE CH47_3346 ENOG41062B0 ABC transporter, permease CH47_3347 ENOG4105CVI Transcriptional regulator CH47_3348 ENOG4107R9N ABC transporter CH47_3349 ENOG4105C2J ABC transporter CH47_3350 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CH47_3358 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CH47_336 ENOG4105TNS Conserved Protein CH47_3360 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) CH47_3361 ENOG4108Y73 Membrane CH47_3362 ENOG4105EJ2 Transcriptional regulator CH47_3363 ENOG4105C5Q Transcriptional regulator CH47_3364 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CH47_3365 ENOG4105EHV domain protein CH47_3366 ENOG4107QN2 dihydrolipoyl dehydrogenase CH47_3369 ENOG4107QZV Type I secretion membrane fusion protein CH47_3375 ENOG4105X58 receptor CH47_3376 ENOG4105CH7 arginosuccinase CH47_3377 ENOG4105CAS nag kinase CH47_3378 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CH47_3381 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CH47_3383 ENOG4105SYT Methylenetetrahydrofolate reductase CH47_3386 ENOG4105CFH Aspartokinase CH47_3387 ENOG4105C28 cystathionine CH47_3388 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) CH47_3389 ENOG4105VFB Binds the 23S rRNA (By similarity) CH47_3390 ENOG4105C25 Primosomal protein n' CH47_3391 ENOG4105ETE Transcriptional regulator (LacI family CH47_3392 ENOG41063M6 Cell Division Protein CH47_3393 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CH47_3394 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CH47_3395 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CH47_3396 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CH47_3397 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) CH47_3398 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CH47_3399 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CH47_34 ENOG4108M1A Chitin-binding protein CH47_340 ENOG41075H3 AraC family transcriptional regulator CH47_3400 ENOG4105CBT Fructose-1,6-bisphosphatase CH47_3401 ENOG4105E5M Multidrug resistance protein D CH47_3402 ENOG4105DP0 ferredoxin-NADP reductase CH47_3403 ENOG4108VTS Membrane CH47_3404 ENOG4105EBK exported protein CH47_3405 ENOG4105CP7 Triose-phosphate isomerase CH47_3406 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CH47_3407 ENOG4105CTQ phosphohexokinase CH47_3408 ENOG41076HS cation diffusion facilitator family transporter CH47_3409 ENOG4105FMW periplasmic CH47_341 ENOG4105F9N Major Facilitator Superfamily CH47_3410 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH47_3411 ENOG4105E0F Histidine kinase CH47_3412 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CH47_3413 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CH47_3414 ENOG4105D7W serine acetyltransferase CH47_3415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CH47_3416 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) CH47_3417 ENOG4105VW4 glutaredoxin 3 CH47_3418 ENOG4107YZP Rhodanese domain protein CH47_3419 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CH47_342 ENOG4108WMJ Protein of unknown function (DUF2002) CH47_3420 ENOG41063SB peptidase CH47_3421 ENOG4105PXI polysaccharide deacetylase CH47_3422 ENOG4105CPQ Dehydrogenase CH47_3423 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CH47_3424 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CH47_3425 ENOG4105XA0 heptosyltransferase ii CH47_3426 ENOG4105D16 lipopolysaccharide heptosyltransferase i CH47_3427 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CH47_3429 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CH47_3430 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CH47_3431 ENOG4105W0E 50S ribosomal protein L33 CH47_3432 ENOG4105KDC 50s ribosomal protein l28 CH47_3433 ENOG4105W5Q DNA repair protein (RadC CH47_3434 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CH47_3435 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CH47_3436 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CH47_3437 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CH47_3438 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CH47_3439 ENOG4105DSJ YicC domain protein CH47_3449 ENOG4105ZTC transcriptional activator, Ogr delta CH47_345 ENOG4105VEQ Cold shock protein CH47_3455 ENOG4105BZU Histidine kinase CH47_3456 ENOG4105E39 Enoyl-CoA hydratase CH47_3457 ENOG4105D9N nucleoside CH47_3459 ENOG4105EN6 Membrane CH47_3460 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) CH47_3462 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CH47_3463 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CH47_3464 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase CH47_3465 ENOG4105CB5 ATP-dependent DNA helicase recG CH47_3466 ENOG4105D6U Sodium Glutamate Symporter CH47_3467 ENOG4105C2W permease CH47_3468 ENOG4105JV1 AsmA family CH47_3474 ENOG4105HVQ Regulatory factor of maltose metabolism CH47_3475 ENOG4105SUU thioesterase domain CH47_3476 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CH47_3477 ENOG4107S2Z UPF0761 membrane protein CH47_3478 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 CH47_3480 ENOG4105C5F glutamine synthetase CH47_3481 ENOG4105CUX Signal transduction histidine kinase CH47_3482 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH47_3483 ENOG4105D4P Coproporphyrinogen iii oxidase CH47_3484 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) CH47_3485 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CH47_3486 ENOG4105C2M dna polymerase I CH47_3487 ENOG4108Z33 Thiol disulfide Interchange Protein CH47_3488 ENOG4105E27 serine threonine protein kinase CH47_3489 ENOG4105PC1 Conserved Protein CH47_3491 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CH47_3496 ENOG4107EJG GntR family transcriptional regulator CH47_3497 ENOG4105ETE Transcriptional regulator (LacI family CH47_3498 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH47_3499 ENOG4108RVA ribokinase CH47_3500 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CH47_3501 ENOG4105CNN ABC, transporter CH47_3503 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CH47_3505 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) CH47_3506 ENOG4105EV2 VWA domain protein interacting with AAA ATPase CH47_3508 ENOG4105CU9 asparagine synthetase A CH47_3509 ENOG4108VVK transcriptional Regulator, AsnC CH47_351 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH47_3510 ENOG4105QTB Flavodoxin CH47_3511 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CH47_3512 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CH47_3513 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation CH47_3514 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) CH47_3515 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH47_3516 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH47_3517 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CH47_3518 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CH47_3519 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CH47_352 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CH47_3520 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CH47_3521 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CH47_3522 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CH47_3523 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CH47_3525 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) CH47_3526 ENOG4105C8U phosphate abc transporter CH47_3527 ENOG4105E2Z phosphate ABC transporter (Permease CH47_353 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) CH47_3531 ENOG4106PMH Extracellular solute-binding protein family 3 CH47_3532 ENOG4105EAD ABC transporter CH47_3533 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 CH47_3534 ENOG4105DRP amino acid AbC transporter CH47_3535 ENOG4105C7N Xanthine uracil vitamin C permease CH47_3538 ENOG4105BZU Histidine kinase CH47_3539 ENOG4108YYH Nadph-dependent fmn reductase CH47_3540 ENOG4105C8Q Methyl-accepting chemotaxis CH47_3541 ENOG4108UMI ABC transporter, permease CH47_3544 ENOG4105RKW reductase (By CH47_3545 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CH47_3546 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CH47_3548 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CH47_3549 ENOG4105VG0 50S ribosomal protein l34 CH47_3550 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CH47_3551 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CH47_3552 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CH47_3553 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH47_3554 ENOG410667J hydrolase CH47_3556 ENOG4105C7B Threonine dehydratase CH47_3557 ENOG4108SGR YheO domain-containing protein CH47_3559 ENOG41090BB DNA mismatch endonuclease (vsr) CH47_356 ENOG4105KI2 Urea amidohydrolase subunit beta CH47_3561 ENOG4105D99 atp gtp-binding protein CH47_3562 ENOG4105R2A (LipO)protein CH47_3566 ENOG4105D0C transport protein CH47_3567 ENOG4105JKW Valine--pyruvate aminotransferase CH47_3568 ENOG4107T9C Alpha amylase catalytic region CH47_3569 ENOG4105C5I Dehydrogenase CH47_357 ENOG4105CQM Urea amidohydrolase subunit alpha CH47_3572 ENOG4108ZG0 Ompa motb domain protein CH47_3575 ENOG4105HNP -acetyltransferase CH47_3576 ENOG4108R3E Dna-3-methyladenine glycosylase i CH47_3577 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CH47_3578 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CH47_3579 ENOG4106JH6 (LipO)protein CH47_358 ENOG4108VDS Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CH47_3581 ENOG4105CTS PTS system mannitol-specific CH47_3582 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CH47_3584 ENOG4105E61 Mannitol repressor protein CH47_3585 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH47_3586 ENOG4108YYI Protein of unknown function (DUF2810) CH47_3588 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A CH47_3589 ENOG4108RPX mosc domain containing protein CH47_359 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CH47_3590 ENOG4105C8Q Methyl-accepting chemotaxis CH47_3591 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CH47_3592 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CH47_3593 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH47_3594 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH47_3595 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein CH47_3596 ENOG4108MG3 formate dehydrogenase CH47_3597 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) CH47_3598 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CH47_3599 ENOG4105EM7 Selenocysteine-specific translation elongation factor CH47_36 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) CH47_360 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CH47_3604 ENOG4105MEV Acyl-transferase CH47_3606 ENOG4108TTM chaperone CH47_3607 ENOG4105CMG Carbohydrate kinase CH47_3608 ENOG4105C93 Xylose Isomerase CH47_3609 ENOG4105DFW ABC transporter CH47_361 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CH47_3611 ENOG4107RNG ABC transporter CH47_3612 ENOG4105T16 Transcriptional regulator (AraC family) CH47_3614 ENOG4105DFP Integrase CH47_3618 ENOG4107R3N Filamentation induced by cAMP protein fic CH47_3624 ENOG41060NJ transcriptional regulator CH47_3625 ENOG4105DKQ ROK family CH47_3626 ENOG4105VCP PTS System CH47_3627 ENOG4105CK1 PTS System CH47_3628 ENOG4105VZJ PTS System CH47_3629 ENOG4105CK1 PTS System CH47_3632 ENOG4105CS2 ec 3.2.1.21 CH47_3633 ENOG4105EIP mannose-6-phosphate isomerase CH47_3634 ENOG4105CGP Urocanate hydratase CH47_3635 ENOG4105C84 Histidine ammonia-lyase CH47_3636 ENOG4105C85 amino acid CH47_3638 ENOG4108ZHJ Organic hydroperoxide resistance protein CH47_3639 ENOG4105DIJ Phosphoethanolamine transferase CH47_364 ENOG4105XXV Acid-resistance protein CH47_3640 ENOG4108KX4 response regulator CH47_3641 ENOG4105BZU Histidine kinase CH47_3642 ENOG4105CXY transporter CH47_3644 ENOG4105CKT filamentous hemagglutinin CH47_3645 ENOG4105D5K Hemolysin activator protein CH47_3646 ENOG4105CKT filamentous hemagglutinin CH47_3647 ENOG4105DEF Extracellular solute-binding protein, family 5 CH47_3648 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CH47_3649 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CH47_365 ENOG4107SVH Potassium channel protein CH47_3650 ENOG4105C3U ABC transporter CH47_3651 ENOG4108JQ7 (ABC) transporter CH47_3652 ENOG4105D1V cellulose synthase operon protein YhjU CH47_3653 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT CH47_3654 ENOG4105U74 cellulose biosynthesis protein BcsE CH47_3657 ENOG4105UTS cellulose synthase operon protein YhjQ CH47_3658 ENOG4107QZ7 Cellulose synthase catalytic subunit CH47_3659 ENOG4107EEX Cellulose synthase regulator protein CH47_366 ENOG41086WQ Protein CrcB homolog CH47_3660 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) CH47_3661 ENOG4105EJG cellulose synthase CH47_3662 ENOG4105BZU Histidine kinase CH47_3663 ENOG4108PU9 oligogalacturonate-specific porin CH47_3666 ENOG4105CK2 sodium dicarboxylate symporter CH47_3667 ENOG4105CS0 peptidase CH47_3668 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CH47_3669 ENOG4105VSH 4-oxalocrotonate tautomerase CH47_3670 ENOG4105CMB EAL domain-containing protein CH47_3671 ENOG41066T0 asmA family CH47_3672 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) CH47_3673 ENOG4107H3J ribonuclease CH47_3675 ENOG4105DC8 reductase CH47_3676 ENOG4105D6S protein involved in catabolism of external DNA CH47_3677 ENOG4105DGW oligopeptidase A CH47_3678 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CH47_3679 ENOG4105QNJ serralysin (EC 3.4.24.40) CH47_368 ENOG4105CPC Aldo Keto reductase CH47_3681 ENOG4108M6U Universal stress protein A CH47_3682 ENOG4108V6B universal stress protein B CH47_3683 ENOG4105CJ3 phosphate transporter CH47_3684 ENOG4105CBX hi0933 family CH47_3685 ENOG4105CK2 sodium dicarboxylate symporter CH47_3689 ENOG4105DJI Methylaspartate mutase, E subunit CH47_369 ENOG4105D8V Glucose sorbosone dehydrogenase CH47_3691 ENOG4107WFU Glutamate mutase subunit sigma CH47_3692 ENOG4105JZC GHMP kinase CH47_3693 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH47_3694 ENOG41090KR LysR family transcriptional Regulator CH47_3695 ENOG4107GFK fumarate CH47_3696 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CH47_3697 ENOG4108HCJ Hydrolase CH47_3698 ENOG4105CR8 Transcriptional regulator CH47_3699 ENOG4105EQ0 Major Facilitator superfamily CH47_370 ENOG4105VZJ PTS System CH47_3701 ENOG4105C26 Dehydrogenase CH47_3702 ENOG4105DH8 myo-inositol catabolism CH47_3704 ENOG4105D7K pfkb domain protein CH47_3706 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CH47_3707 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CH47_3708 ENOG4105WCN acetyltransferase CH47_3709 ENOG4105C2I pirin domain protein CH47_371 ENOG4105CK1 PTS System CH47_3710 ENOG4105DIQ Transcriptional regulator CH47_3711 ENOG4105C6Z Gluconate CH47_3712 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CH47_3713 ENOG41076UM multiple antibiotic resistance (MarC)-related protein CH47_3714 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH47_3715 ENOG4105C7K acetolactate synthase CH47_3717 ENOG4108HRK Histidine kinase CH47_3719 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CH47_372 ENOG4105CS2 ec 3.2.1.21 CH47_3720 ENOG4108IUM Glycogen debranching enzyme CH47_3722 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CH47_3723 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CH47_3724 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CH47_3726 ENOG4105E0F Histidine kinase CH47_3727 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CH47_3728 ENOG4108RRZ Transcription elongation factor GreB CH47_373 ENOG4105VCP PTS System CH47_3731 ENOG4105BZM domain protein CH47_3732 ENOG4105XFK Ferrous iron transport protein A CH47_3733 ENOG4105CE1 Ferrous iron transport protein b CH47_3734 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) CH47_3735 ENOG4105RID UPF0379 protein yhcN CH47_3736 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CH47_3737 ENOG4105MJ2 Competence protein CH47_3738 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) CH47_3739 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) CH47_374 ENOG4105EZV Transcriptional regulator CH47_3740 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CH47_3741 ENOG41061ZR Transcriptional regulator CH47_3743 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) CH47_3744 ENOG4105E98 transcriptional regulator DeoR family CH47_3745 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CH47_3747 ENOG4105VEJ Heat shock protein CH47_3748 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CH47_3749 ENOG4105DQY intracellular growth attenuator CH47_375 ENOG410901P UPF0249 protein CH47_3750 ENOG4107RK2 ADP-ribose diphosphatase NudE CH47_3751 ENOG4108JQC penicillin-binding protein 1A CH47_3756 ENOG4105E4G Type IV pilus CH47_3757 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CH47_376 ENOG4105CHH sulfate transporter CH47_3761 ENOG4105DJV ribulose-phosphate 3-epimerase CH47_3763 ENOG4105C31 Tryptophanyl-tRNA synthetase CH47_3764 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CH47_3765 ENOG4107V9H nitrite transporter CH47_3766 ENOG4105WZK nitrite reductase NADPH small subunit CH47_3767 ENOG4107QZF nitrite reductase NADPH large subunit CH47_3768 ENOG4105DZC cytosine deaminase CH47_3769 ENOG4106DTQ Protein TsgA homolog CH47_377 ENOG4105DFP Integrase CH47_3770 ENOG41060NJ transcriptional regulator CH47_3771 ENOG4105F8D glycoside hydrolase family 4 CH47_3772 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CH47_3773 ENOG4105D7A ATP-binding protein CH47_3775 ENOG4105C8Y Acetylornithine aminotransferase CH47_3776 ENOG410613R integral membrane protein, YccS YhfK family CH47_3778 ENOG4108UKZ OsmC family CH47_3779 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) CH47_378 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_3780 ENOG4105YP7 UPF0270 protein CH47_3781 ENOG4105DNZ Alpha Beta Hydrolase CH47_3783 ENOG4105JAB phenazine biosynthesis protein, phzf family CH47_3784 ENOG4106FTQ Taurine ABC transporter, periplasmic CH47_3786 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CH47_3787 ENOG4105E2B Taurine dioxygenase CH47_3789 ENOG4105K64 Glycosyl transferase, family 2 CH47_3790 ENOG4105C5H ABC transporter CH47_3791 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CH47_3793 ENOG4105VKU nucleicacid-binding protein CH47_3794 ENOG4108YZY peptidylprolyl cis-trans isomerase CH47_3796 ENOG4108V1T peptidylprolyl cis-trans isomerase CH47_3797 ENOG4105WWK YheO domain protein CH47_3798 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CH47_3799 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH47_3800 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) CH47_3802 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CH47_3804 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CH47_3809 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CH47_3810 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CH47_3811 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CH47_3812 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CH47_3813 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CH47_3814 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CH47_3815 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CH47_3816 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CH47_3817 ENOG41083MP 50s ribosomal protein l29 CH47_3818 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CH47_3820 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CH47_3821 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CH47_3822 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CH47_3823 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CH47_3824 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CH47_3825 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CH47_3826 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CH47_3827 ENOG4105VPB 50S ribosomal protein L30 CH47_3828 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CH47_3829 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CH47_3830 ENOG41067V7 50S ribosomal protein L36 CH47_3831 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CH47_3832 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CH47_3833 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CH47_3834 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CH47_3835 ENOG4108ZT0 50S ribosomal protein l17 CH47_3836 ENOG4105VTS DnaJ-like, subfamily C CH47_3837 ENOG4105W1Y Transcriptional regulator CH47_3838 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system CH47_3839 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CH47_3840 ENOG4105C1A potassium transporter peripheral membrane CH47_3841 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CH47_3842 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CH47_3843 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CH47_3844 ENOG4105C79 DNA protecting protein DprA CH47_3846 ENOG4108WI1 Dna topoisomerase CH47_3847 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH47_3848 ENOG4105E2X shikimate dehydrogenase CH47_3849 ENOG4108Z0R Transferase CH47_3858 ENOG4105CVG Homoserine O-transsuccinylase CH47_3859 ENOG4107QP3 malate synthase g CH47_3860 ENOG4108I9X Isocitrate lyase CH47_3861 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) CH47_3862 ENOG41069M3 Transcriptional regulator CH47_3863 ENOG4105C3R Methionine synthase CH47_3865 ENOG4105CFH Aspartokinase CH47_3866 ENOG4107QP8 phosphohexose isomerase CH47_3867 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CH47_3868 ENOG4105EG2 ABC transporter, permease CH47_3869 ENOG4105D56 permease protein CH47_3870 ENOG4107FKK extracellular solute-binding protein family 1 CH47_3872 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) CH47_3873 ENOG4107W52 maltose operon periplasmic protein CH47_3875 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) CH47_3876 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) CH47_3877 ENOG4105E55 glycerol-3-phosphate acyltransferase CH47_3878 ENOG41080IJ Diacylglycerol kinase CH47_3879 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CH47_3880 ENOG4105VDW Csbd family CH47_3881 ENOG4105MYN Zinc uptake regulation protein CH47_3885 ENOG41077V0 CPS-53 (KpLE1) prophage CH47_3887 ENOG4108R7K Metal Dependent Phosphohydrolase CH47_3888 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) CH47_3889 ENOG4105H40 CH47_3897 ENOG4105CAR Terminase, large subunit CH47_390 ENOG4105ZTC transcriptional activator, Ogr delta CH47_3901 ENOG4108MXB Protein of unknown function (DUF968) CH47_3902 ENOG4105HRS Antitermination protein CH47_3904 ENOG4105EW9 transcriptional regulator AsnC family CH47_3911 ENOG4106050 phage regulatory protein, rha family CH47_3929 ENOG4105TKZ Tail Sheath CH47_393 ENOG4105DFP Integrase CH47_3941 ENOG4105UZW Tail fiber assembly protein CH47_3944 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH47_3945 ENOG4105P4Z Phage shock protein G CH47_3947 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CH47_3948 ENOG4105CDU Replicative dna helicase CH47_3949 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CH47_3950 ENOG4105CGF Aromatic amino acid aminotransferase CH47_3951 ENOG4105MSB protein, conserved in bacteria CH47_3952 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CH47_3954 ENOG4105CAF HipA N-terminal domain protein CH47_3955 ENOG41067QW Transcriptional regulator CH47_3957 ENOG4105C7N Xanthine uracil vitamin C permease CH47_3958 ENOG4105EEQ Na H antiporter CH47_3959 ENOG4105CMU LysR family (Transcriptional regulator CH47_3962 ENOG4105CDA abc transporter atp-binding protein CH47_3963 ENOG4105DRP amino acid AbC transporter CH47_3964 ENOG4105EZ7 amino acid ABC transporter CH47_3967 ENOG4105D1S lipid A biosynthesis CH47_3971 ENOG4105VEQ Cold shock protein CH47_3972 ENOG4105VEQ Cold shock protein CH47_3973 ENOG4108XTF Outer Membrane Lipoprotein CH47_3974 ENOG4105BZU Histidine kinase CH47_3975 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CH47_3976 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CH47_3977 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CH47_3978 ENOG4108IA2 Sodium pantothenate symporter CH47_3979 ENOG4105RG0 Membrane CH47_3980 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CH47_3981 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CH47_3982 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CH47_3983 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CH47_3985 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CH47_3986 ENOG41062P1 Diguanylate cyclase phosphodiesterase CH47_3988 ENOG4105DFF Rod shape-determining protein mreb CH47_3989 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CH47_3990 ENOG4105VQ7 Rod shape-determining protein MreD CH47_3992 ENOG4105C03 ribonuclease CH47_3993 ENOG4105QD6 exported protein CH47_3995 ENOG4105D1U peptidase U62 modulator of DNA gyrase CH47_3996 ENOG4105CR8 Transcriptional regulator CH47_3997 ENOG4105ZQC membrane protein AaeX CH47_3998 ENOG4105Y49 secretion protein, HlyD family CH47_3999 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CH47_4 ENOG4108USZ hydrogenase CH47_4002 ENOG4105UNR (Barnase) inhibitor CH47_4003 ENOG4105N42 UPF0307 protein CH47_4004 ENOG4105CMS peptidase U62, modulator of DNA gyrase CH47_4005 ENOG4108XVM Cytochrome b(562) CH47_4006 ENOG4105NXH GreA GreB family elongation factor CH47_4012 ENOG41069H0 dihydroorotase EC 3.5.2.3 CH47_4015 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CH47_4016 ENOG4105EMD TRANSCRIPTIONal CH47_4017 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CH47_4018 ENOG4105D4X repressor CH47_4019 ENOG4105C5Y PTS System CH47_4020 ENOG4105CG3 alpha amylase, catalytic region CH47_4026 ENOG4105KME endoribonuclease L-psp CH47_4027 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) CH47_4028 ENOG4105CXT aspartate transcarbamylase CH47_4030 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_4033 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_4034 ENOG41080Z8 PHOSPHOCARRIER protein CH47_4035 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CH47_4036 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CH47_4037 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA CH47_4038 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH47_4039 ENOG4108IUZ ABC transporter CH47_4040 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CH47_4041 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) CH47_4042 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CH47_4043 ENOG4105C2X Arabinose 5-phosphate isomerase CH47_4044 ENOG4105FEU K -dependent Na -Ca exchanger CH47_4045 ENOG4105DHJ ABC, transporter CH47_4046 ENOG4105CY3 ABC transporter, permease CH47_4047 ENOG4107PE3 Mammalian cell entry related domain protein CH47_4048 ENOG4105E3I toluene tolerance CH47_4049 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane CH47_4050 ENOG4105VFK BolA family CH47_4051 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CH47_4052 ENOG4105C0H protease CH47_4053 ENOG4105C0H protease CH47_4054 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III CH47_4055 ENOG4105D6Z AFG1 family ATPase CH47_4056 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CH47_4057 ENOG4108UJD 30S ribosomal protein S9 CH47_4058 ENOG4107MKT Stringent starvation protein a CH47_4059 ENOG4105KB2 stringent starvation protein b CH47_4061 ENOG4105BZ8 glutamate synthase CH47_4062 ENOG4105CBC glutamate synthase CH47_4063 ENOG4105N5T Radical SAM Protein CH47_4064 ENOG4105BZU Histidine kinase CH47_4065 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain CH47_4066 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CH47_4067 ENOG4105W4M Transport-associated protein CH47_4068 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CH47_4069 ENOG41082RQ UPF0102 protein CH47_4071 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CH47_4074 ENOG4105EQ2 LysR family Transcriptional regulator CH47_4075 ENOG4107SET aldo keto reductase CH47_4076 ENOG4105DQ4 alcohol dehydrogenase CH47_4077 ENOG4108CNN domain protein CH47_4078 ENOG4105CWB LysR family transcriptional Regulator CH47_4079 ENOG4105CHF Glutathione S-transferase CH47_4080 ENOG4108VBZ doxx family CH47_4081 ENOG4105YJD CH47_4082 ENOG41090KG Inner membrane protein YqjE CH47_4083 ENOG4105NE1 Conserved Protein CH47_4086 ENOG4106W5V Membrane CH47_409 ENOG4105DFP Integrase CH47_4090 ENOG4105DPW Major facilitator superfamily MFS_1 CH47_4091 ENOG4105D2H Uronic isomerase CH47_4092 ENOG4107QZW Altronate oxidoreductase CH47_4093 ENOG4105CTX dehydratase CH47_4094 ENOG4105P66 Membrane CH47_4095 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CH47_4096 ENOG4105DU1 integral membrane protein, terc CH47_4097 ENOG4105EE0 oxidoreductase CH47_4098 ENOG4108VKG metal-dependent hydrolase CH47_41 ENOG4105X5Z General secretion pathway protein I CH47_410 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CH47_4100 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CH47_4101 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CH47_4102 ENOG4108594 Permease of the drug metabolite transporter CH47_4103 ENOG4108YK4 Acid-resistance membrane protein CH47_4106 ENOG4105CVK Glutamate decarboxylase CH47_4107 ENOG4105E5D amino acid CH47_4108 ENOG4105CSV Glutaminase CH47_4109 ENOG4105C5Y PTS System CH47_411 ENOG4108Z1B Cyclase dehydrase CH47_4110 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CH47_4111 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) CH47_4112 ENOG4105D17 glycoside hydrolase, family 3 domain protein CH47_4114 ENOG4105EHZ conserved protein UCP016719 CH47_4116 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CH47_4117 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CH47_4118 ENOG4105VCC 30S ribosomal protein S21 CH47_4119 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CH47_4120 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CH47_4121 ENOG4107ZVW dihydroneopterin aldolase CH47_4122 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CH47_4123 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CH47_4124 ENOG4106MWK domain protein CH47_4125 ENOG4105I7R Adenylate cyclase CH47_4126 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CH47_4127 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CH47_4128 ENOG4105DVH amino acid CH47_4129 ENOG4105W0Z cytoplasmic protein CH47_413 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH47_4130 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CH47_4131 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CH47_4132 ENOG4106032 Glutathionylspermidine synthase CH47_4133 ENOG4105F1G UPF0441 protein CH47_4134 ENOG4105DFG type I secretion outer membrane protein CH47_4135 ENOG41087AY ADP-Ribose pyrophosphatase CH47_4136 ENOG4108SX3 cytoplasmic protein CH47_4139 ENOG4105IPS esterase CH47_414 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CH47_4140 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH47_4141 ENOG4105JQN Transcriptional regulator CH47_4142 ENOG4105VRH Antibiotic biosynthesis monooxygenase CH47_4143 ENOG4105NF4 modulator of drug activity CH47_4144 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH47_4145 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase CH47_4146 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CH47_4148 ENOG4105CV8 reductase CH47_4149 ENOG4108I6A alcohol dehydrogenase CH47_415 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CH47_4150 ENOG4105CF7 AraC family transcriptional regulator CH47_4151 ENOG4108K81 inner membrane protein YghB CH47_4152 ENOG4105C28 cystathionine CH47_4153 ENOG4105CWK Biopolymer transport protein, ExbB CH47_4154 ENOG4108ZZF transport protein (ExbD) CH47_416 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CH47_4169 ENOG4105CF1 Alkylated DNA repair protein CH47_417 ENOG4108RS6 transposase CH47_4170 ENOG4108IJF Heavy metal efflux pump, CzcA CH47_4171 ENOG4105EP1 Efflux transporter rnd family, mfp subunit CH47_4178 ENOG4105E0A ABC, transporter CH47_4179 ENOG4105TVJ transport system, permease CH47_418 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CH47_4180 ENOG4105DQ5 transport system permease protein CH47_4181 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein CH47_4182 ENOG4105CSP Major Facilitator Superfamily CH47_4183 ENOG4105EXW epimerase dehydratase CH47_4184 ENOG4105C8Q Methyl-accepting chemotaxis CH47_4185 ENOG4107ZUJ lipid metabolic process CH47_4187 ENOG4108XTF Outer Membrane Lipoprotein CH47_419 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) CH47_42 ENOG4105VWV general secretion pathway protein h CH47_4215 ENOG4105D5G Transposase CH47_422 ENOG4105C1J atp-dependent rna helicase CH47_4228 ENOG4108RS6 transposase CH47_4229 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_423 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) CH47_4238 ENOG4105CMM transposase CH47_424 ENOG4108IYU L-aspartate oxidase CH47_4244 ENOG4105D5G Transposase CH47_4247 ENOG4105DWP Membrane CH47_4250 ENOG4105EZN Cobyrinic acid ac-diamide synthase CH47_4251 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB CH47_426 ENOG41069PW sigma-e factor negative regulatory protein CH47_428 ENOG4105WMJ Positive regulator of sigma E, RseC MucC CH47_43 ENOG4108VAU general secretion pathway protein G CH47_430 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CH47_431 ENOG4105C3F Signal peptidase i CH47_432 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CH47_433 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CH47_434 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CH47_435 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CH47_436 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CH47_437 ENOG4107EFN gluconate transport system permease 3 CH47_438 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CH47_439 ENOG4106G6Q Transcriptional regulator CH47_44 ENOG4105D7Q type ii secretion system CH47_441 ENOG4105HVQ Regulatory factor of maltose metabolism CH47_443 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB CH47_445 ENOG4108Z6B deaminase CH47_446 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) CH47_45 ENOG4107QHF type ii secretion system protein e CH47_450 ENOG4107WP9 Histidine kinase CH47_451 ENOG4108SKK alpha helix protein CH47_452 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CH47_453 ENOG4105C4K Nad synthetase CH47_454 ENOG4108YZA Nitrogen regulatory protein pii CH47_455 ENOG4106M0N transport system permease protein CH47_456 ENOG4105MUZ Protein of unknown function DUF2620 CH47_457 ENOG41080QX K07048 phosphotriesterase-related protein CH47_458 ENOG4108626 Racemase CH47_459 ENOG4105RMW regulation of transcription, DNA-dependent CH47_460 ENOG4108M21 CH47_461 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH47_462 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CH47_463 ENOG4108MN2 Stationary phase inducible protein CsiE CH47_464 ENOG4105D8G Major Facilitator superfamily CH47_465 ENOG41065CD Exported protein CH47_466 ENOG4105D7X high-affinity nickel-transporter CH47_470 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CH47_471 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CH47_472 ENOG4105C3J Cysteine desulfurase CH47_473 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CH47_474 ENOG4108Z4V iron-sulfur cluster assembly CH47_475 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) CH47_476 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB CH47_477 ENOG4108ZIT Ferredoxin, 2FE-2S CH47_478 ENOG4105WVQ Fe-S assembly protein IscX CH47_480 ENOG4105YYA enhanced serine sensitivity protein SseB CH47_481 ENOG4105DN3 alpha-2-macroglobulin domain protein CH47_482 ENOG4108JQB penicillin-binding protein 1C CH47_484 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CH47_485 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CH47_487 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CH47_488 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CH47_489 ENOG4105CUT histidyl-tRNA synthetase CH47_490 ENOG4105N21 Membrane CH47_491 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH47_492 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CH47_494 ENOG4105VPD cellular component movement CH47_495 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CH47_496 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CH47_497 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CH47_5 ENOG4108WGS hydrogenase 2-specific chaperone CH47_504 ENOG4105DWF phosphomethylpyrimidine kinase CH47_507 ENOG4108ZGU inhibitor of vertebrate lysozyme CH47_508 ENOG4105C2X Arabinose 5-phosphate isomerase CH47_509 ENOG410804X Transcriptional regulator CH47_510 ENOG4105J92 DNA-binding transcriptional activator GutM CH47_511 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase CH47_512 ENOG4105VI0 Pts system, glucitol sorbitol-specific CH47_513 ENOG4105DZY Pts system, glucitol sorbitol-specific CH47_514 ENOG410787A Pts system, glucitol sorbitol-specific CH47_516 ENOG4107TE5 Lipid kinase CH47_517 ENOG4105CFP Peptidase U32 CH47_520 ENOG4105KWI UPF0339 protein CH47_521 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH47_522 ENOG4105EB3 Histidine kinase CH47_523 ENOG4105C0R drug resistance transporter emrb qaca subfamily CH47_524 ENOG4105BZS acriflavin resistance protein CH47_526 ENOG4105ENT Efflux transporter rnd family, mfp subunit CH47_528 ENOG41074HU Fimbrial adhesin CH47_529 ENOG4105CW0 outer membrane usher protein CH47_530 ENOG4108VCD Chaperone CH47_532 ENOG4105R8A Heat shock protein CH47_533 ENOG4105BZU Histidine kinase CH47_534 ENOG4105CJW magnesium transporter CH47_536 ENOG4105C9X ppx gppa phosphatase CH47_537 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CH47_538 ENOG4105CMM transposase CH47_54 ENOG4105XJC Two component transcriptional regulator (Winged helix family CH47_541 ENOG4108MK9 spermidine N(1)-acetyltransferase CH47_542 ENOG4108V3E phosphoribosylglycinamide formyltransferase CH47_543 ENOG4105CXB phosphoribosylaminoimidazole synthetase CH47_544 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CH47_545 ENOG4105C2W permease CH47_546 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) CH47_547 ENOG4105K89 arsenate reductase CH47_548 ENOG4105ERG peptidase m48, ste24p CH47_549 ENOG4105C02 permease CH47_55 ENOG4105WH1 Two component transcriptional regulator luxr family CH47_550 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH47_551 ENOG4105RH4 Glycine cleavage system transcriptional repressor CH47_552 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CH47_553 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CH47_554 ENOG4105C8V SAICAR synthetase CH47_555 ENOG4105CGZ zinc metallopeptidase CH47_556 ENOG4108VMM UPF0756 membrane protein CH47_557 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) CH47_558 ENOG4106KED esterase YpfH CH47_559 ENOG4105XYK UPF0370 protein CH47_561 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CH47_562 ENOG4105KUZ arsenate reductase CH47_566 ENOG4105BZS acriflavin resistance protein CH47_568 ENOG4105WH1 Two component transcriptional regulator luxr family CH47_570 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase CH47_571 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CH47_572 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) CH47_573 ENOG4105CUW cytochrome C-TYPE protein CH47_576 ENOG4107VIJ nudix hydrolase CH47_577 ENOG4105C6K Malic enzyme CH47_578 ENOG4108Q9V regulatoR CH47_580 ENOG4108UPT UPF0178 protein CH47_581 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CH47_582 ENOG4108R6G acetyltransferase CH47_583 ENOG4105H4F exported protein CH47_584 ENOG4105E7K (LipO)protein CH47_585 ENOG4105EZR dyp-type peroxidase family protein CH47_589 ENOG4108R66 Conserved Protein CH47_590 ENOG4105QEK Transcriptional regulator CH47_592 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein CH47_593 ENOG4108I5D sulfate abc transporter CH47_594 ENOG4105ECW sulfate abc transporter CH47_596 ENOG4105C6T cysteine synthase CH47_598 ENOG4105DJY efflux transporter, rnd family, mfp subunit CH47_599 ENOG4105E3W Two component transcriptional regulator (Winged helix family CH47_6 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CH47_600 ENOG4105E0F Histidine kinase CH47_601 ENOG4105C5Y PTS System CH47_602 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CH47_603 ENOG4105KZ7 phosphocarrier protein hpr CH47_604 ENOG4105C6T cysteine synthase CH47_607 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CH47_608 ENOG4105VRT cytoplasmic protein CH47_614 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CH47_619 ENOG4105D9N nucleoside CH47_62 ENOG4108RBT type iii secretion CH47_620 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CH47_622 ENOG4105CPC Aldo Keto reductase CH47_623 ENOG4105C5Q Transcriptional regulator CH47_624 ENOG4107RA9 decarboxylase CH47_626 ENOG4105CHC glucokinase (EC 2.7.1.2) CH47_627 ENOG4105FCD Major Facilitator CH47_628 ENOG4105DY9 regulatoR CH47_629 ENOG4108HRK Histidine kinase CH47_630 ENOG41072TH Protein of unknown function (DUF1479) CH47_632 ENOG4105CHM Aminotransferase CH47_633 ENOG4108VKM cytochrome b561 CH47_634 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin CH47_635 ENOG4106B0W Curli production assembly transport component CsgG CH47_637 ENOG4107Y60 (LipO)protein CH47_640 ENOG4105E82 cytochrome subunit of dehydrogenase CH47_641 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH47_644 ENOG4105CVE Lytic murein transglycosylase CH47_645 ENOG4105CUB amino acid CH47_649 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_651 ENOG4105DHJ ABC, transporter CH47_656 ENOG4105DS1 cytochrome b561 CH47_657 ENOG4108YYC ycei family CH47_658 ENOG4105DDV Transcriptional regulator (LacI family CH47_659 ENOG4105C5Y PTS System CH47_66 ENOG4108KB1 transcriptional regulator, arac family CH47_660 ENOG4105CS2 ec 3.2.1.21 CH47_662 ENOG4105NTW Transcriptional regulator CH47_663 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CH47_664 ENOG4105DFP Integrase CH47_67 ENOG4105K44 type iii secretion CH47_675 ENOG4105DFP Integrase CH47_678 ENOG4105S64 Formate nitrite transporter CH47_68 ENOG4105X27 type iii secretion CH47_680 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CH47_681 ENOG41060IM Heme exporter protein CH47_682 ENOG4105X3C heme exporter protein CH47_683 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) CH47_684 ENOG4105DA4 cytochrome c-type biogenesis protein CH47_685 ENOG4107QX9 Thiol disulfide interChange protein CH47_686 ENOG4108M1T Cytochrome c-type biogenesis protein CH47_687 ENOG4105KWW Biogenesis protein CH47_688 ENOG410903C (LipO)protein CH47_69 ENOG4108HR8 type iii secretion CH47_691 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation CH47_692 ENOG4105KZW UPF0381 protein CH47_693 ENOG4105CHU acetyl-coa acetyltransferase CH47_694 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CH47_695 ENOG4108BY2 phosphohistidine phosphatase CH47_696 ENOG4108DG9 Smr protein MutS2 CH47_698 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CH47_699 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CH47_7 ENOG4107RSS Hydrogenase accessory protein HypB CH47_700 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CH47_701 ENOG4105EJ9 Membrane CH47_702 ENOG4108BPE -transporting atpase CH47_703 ENOG4105MH2 YfcL protein CH47_704 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CH47_705 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CH47_706 ENOG4105BZU Histidine kinase CH47_709 ENOG4105VCP PTS System CH47_71 ENOG4108JIR Flagellum-specific ATP synthase CH47_710 ENOG4105CS2 ec 3.2.1.21 CH47_711 ENOG4105CK1 PTS System CH47_713 ENOG4105ETE Transcriptional regulator (LacI family CH47_714 ENOG4105D6F Phosphatase CH47_715 ENOG4105F4P )-transporter CH47_716 ENOG4106WZ1 flagella biosynthesis regulator CH47_717 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CH47_719 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CH47_720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CH47_722 ENOG410631K Membrane CH47_724 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) CH47_726 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CH47_728 ENOG4105DQR SNARE associated Golgi CH47_729 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CH47_730 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CH47_731 ENOG4108S3P Sporulation domain protein CH47_732 ENOG4105E96 Colicin v production protein CH47_733 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CH47_734 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CH47_735 ENOG4105E89 ABC transporter CH47_736 ENOG4105DSP amino acid AbC transporter CH47_737 ENOG4106YG3 ABC transporter CH47_738 ENOG4108JEH abc transporter atp-binding protein CH47_740 ENOG4105ECP epimerase CH47_744 ENOG4105PTV Nudix Hydrolase CH47_745 ENOG4108RS6 transposase CH47_746 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_747 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CH47_749 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CH47_75 ENOG41075IY surface presentation of antigens protein SpaP CH47_750 ENOG4107P2S Transcriptional regulator CH47_751 ENOG4108RS6 transposase CH47_752 ENOG4105C6K Malic enzyme CH47_754 ENOG4105PQ6 UPF0208 membrane protein CH47_755 ENOG4105XWI UPF0304 protein CH47_756 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CH47_758 ENOG4107QWE )-transporter CH47_759 ENOG4105DK2 UPF0207 protein CH47_760 ENOG4105CHM Aminotransferase CH47_761 ENOG4107NQ8 LysR family Transcriptional regulator CH47_762 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CH47_763 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH47_764 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH47_765 ENOG4105GKE subunit e CH47_766 ENOG4107QIZ NADH dehydrogenase CH47_767 ENOG4108IEH NADH dehydrogenase subunit g CH47_768 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CH47_769 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH47_77 ENOG4108TN6 type iii secretion CH47_770 ENOG4107UFS subunit j CH47_771 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH47_772 ENOG4105D65 subunit l CH47_773 ENOG4105C8S subunit m CH47_774 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CH47_776 ENOG4108UQ5 membrane protein YcdZ CH47_777 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_778 ENOG4105EQR Transposase IS116 IS110 IS902 CH47_780 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CH47_781 ENOG4105CHR reductase CH47_782 ENOG4105K2J Transcriptional regulator CH47_783 ENOG4105C5I Dehydrogenase CH47_785 ENOG41090KN UPF0303 protein CH47_786 ENOG4105C01 Dihydroxy-acid dehydratase CH47_790 ENOG4105TNS Conserved Protein CH47_793 ENOG4105E4F Isochorismate synthase CH47_794 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CH47_795 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CH47_796 ENOG4108IPT Naphthoate synthase CH47_797 ENOG4105DNI Converts SHCHC to OSB (By similarity) CH47_798 ENOG4105CEY Amp-dependent synthetase and ligase CH47_799 ENOG4105CH6 catalase CH47_8 ENOG41082MF Hydrogenase assembly chaperone hypC hupF CH47_800 ENOG4108UII YfaZ family CH47_801 ENOG4105E0U tyrosine-specific transport protein CH47_806 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) CH47_807 ENOG4105XPH Ferredoxin CH47_808 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH47_809 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CH47_810 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CH47_811 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CH47_812 ENOG4105BZU Histidine kinase CH47_813 ENOG41068CG regulatoR CH47_814 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC CH47_815 ENOG4106UW1 Major Facilitator superfamily CH47_816 ENOG4105C42 Type I secretion membrane fusion protein (HlyD CH47_820 ENOG4107R6D beta-lactam binding protein AmpH CH47_821 ENOG4105CT4 transporter CH47_823 ENOG4105C8Q Methyl-accepting chemotaxis CH47_826 ENOG4105Y50 Virulence Protein CH47_829 ENOG4105HRS Antitermination protein CH47_831 ENOG4105D5G Transposase CH47_832 ENOG4108Q3X Transcriptional regulator CH47_833 ENOG4105C5Y PTS System CH47_834 ENOG4105CS2 ec 3.2.1.21 CH47_837 ENOG4105E68 Sulfatase CH47_838 ENOG4105PAN UPF0352 protein CH47_839 ENOG4106V8H Nucleoid-associated protein CH47_840 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CH47_841 ENOG4105CFI type iii restriction protein res subunit CH47_842 ENOG4105I08 Pseudouridine synthase CH47_843 ENOG4105C2C drug resistance transporter, Bcr CflA CH47_844 ENOG4105HG6 CH47_845 ENOG4108JQ5 ABC transporter CH47_846 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CH47_847 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CH47_848 ENOG4105E43 Extracellular solute-binding protein, family 5 CH47_851 ENOG4107TT5 NLP P60 protein CH47_852 ENOG41076MN Phosphoesterase, PA-phosphatase related CH47_853 ENOG4105CKI cobalamin synthesis protein CH47_855 ENOG4107YCY Transcriptional regulator CH47_856 ENOG4105DEI Mannitol dehydrogenase CH47_857 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CH47_858 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CH47_860 ENOG4105KRS Proteinase inhibitor CH47_861 ENOG4107QY8 reductase CH47_862 ENOG4105CUW cytochrome C-TYPE protein CH47_864 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CH47_865 ENOG4105DE4 1-phosphofructokinase CH47_866 ENOG4105DM4 PTS System CH47_867 ENOG4108SGD regulatory protein CH47_87 ENOG4105J12 Multidrug resistance protein mdtN CH47_870 ENOG4108UIF Chaperone CH47_871 ENOG4108D1K outer membrane usher protein CH47_872 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CH47_873 ENOG4105HMI Membrane CH47_875 ENOG4105DUM transcriptional regulator, lysR family CH47_876 ENOG4108IQI permease CH47_877 ENOG4105EHG Permease protein CH47_879 ENOG4105D05 Receptor CH47_88 ENOG4108MI0 Resistance protein CH47_880 ENOG4108TGY Glutathione S-transferase CH47_884 ENOG4105D01 (LipO)protein CH47_886 ENOG4108UMI ABC transporter, permease CH47_887 ENOG4105C28 cystathionine CH47_889 ENOG4105DZ1 carboxypeptidase CH47_890 ENOG4105EJQ L-serine dehydratase CH47_891 ENOG4105C44 Serine transporter CH47_892 ENOG4107FB0 transcriptional regulator DeoR family CH47_893 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CH47_894 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CH47_9 ENOG4105CQS hydrogenase expression formation protein HypD CH47_90 ENOG4105CXN decarboxylase CH47_900 ENOG4105MEH CH47_906 ENOG4105VZ1 Replication Protein CH47_909 ENOG4105ED4 portal protein CH47_91 ENOG4105D5Q Arginine ornithine antiporter CH47_933 ENOG4105D0C transport protein CH47_936 ENOG41090BQ Glutaredoxin CH47_937 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress CH47_938 ENOG4108RMJ sensory transduction regulator CH47_939 ENOG4107RUE extracellular solute-binding protein family 1 CH47_940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CH47_941 ENOG4105F38 ABC transporter, permease CH47_942 ENOG4105D38 putrescine abc transporter CH47_943 ENOG4105RBQ inner membrane protein ybjO CH47_944 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) CH47_945 ENOG4106TNF Periplasmic binding protein CH47_947 ENOG4105DMR ABC, transporter CH47_948 ENOG4105GBT ABC transporter CH47_949 ENOG4106PMH Extracellular solute-binding protein family 3 CH47_950 ENOG4105E5Z arginine transporter ATP-binding subunit CH47_951 ENOG41064MM (LipO)protein CH47_952 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CH47_953 ENOG4105CGD Nad-dependent epimerase dehydratase CH47_954 ENOG4105C5W Aldolase CH47_956 ENOG4105C7K acetolactate synthase CH47_957 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CH47_958 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CH47_959 ENOG4105DWU Membrane CH47_960 ENOG4108MJ5 VirK protein CH47_961 ENOG4105CPB ATP-dependent endonuclease of the OLD family CH47_962 ENOG4105DJY efflux transporter, rnd family, mfp subunit CH47_964 ENOG4105VEQ Cold shock protein CH47_965 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CH47_966 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CH47_967 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CH47_968 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CH47_969 ENOG4108JJ8 (ABC) transporter CH47_970 ENOG4108JJ9 ABC, transporter CH47_971 ENOG4105C3M thioredoxin reductase CH47_973 ENOG4105EW9 transcriptional regulator AsnC family CH47_974 ENOG4105CNU cell division protein FtsK CH47_976 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CH47_977 ENOG4105D1H recombination factor protein RarA CH47_978 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CH47_979 ENOG4108ISG Major Facilitator CH47_980 ENOG4105F1A Pyruvate formate-lyase CH47_981 ENOG4105C6N Formate acetyltransferase CH47_982 ENOG4105TMB Formate nitrite transporter CH47_983 ENOG4105DDY UPF0142 protein ycaO CH47_984 ENOG4105HDK L-asparaginase CH47_985 ENOG4107VMU Membrane CH47_986 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CH47_987 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CH47_988 ENOG4105CAT Cytidine monophosphate kinase CH47_989 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CH47_990 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CH47_991 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CH47_993 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CH47_994 ENOG4105E32 cytoplasmic protein CH47_995 ENOG4105VEQ Cold shock protein CH47_996 ENOG4105VEQ Cold shock protein CH47_997 ENOG4105W49 UPF0434 protein CH47_998 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CH47_999 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups