locus-tag	class	description
CH47_1	COG0437	4 iron, 4 sulfur cluster binding
CH47_10	COG0309	Hydrogenase expression formation protein (HypE)
CH47_1000	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH47_1001	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH47_1002	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH47_1003	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CH47_1004	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH47_1005	COG2989	Protein conserved in bacteria
CH47_1006	COG3108	Peptidase M15
CH47_1007	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH47_1008	COG2200	EAL domain
CH47_1009	COG1448	Aminotransferase
CH47_1011	COG0017	Asparaginyl-tRNA synthetase
CH47_1012	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH47_1014	COG0308	aminopeptidase N
CH47_1015	COG0167	dihydroorotate dehydrogenase activity
CH47_1017	COG3217	Mosc domain protein beta barrel domain protein
CH47_1017	COG0633	Ferredoxin
CH47_1018	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH47_1018	COG0116	Belongs to the methyltransferase superfamily
CH47_1019	COG0488	(ABC) transporter
CH47_1020	COG2995	paraquat-inducible protein a
CH47_1021	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH47_1021	COG3008	intermembrane lipid transfer
CH47_1022	COG3009	Protein conserved in bacteria
CH47_1023	COG3130	regulation of translation
CH47_1024	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH47_1026	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH47_1027	COG1067	ATP-dependent peptidase activity
CH47_1028	COG3120	sequence-specific DNA binding
CH47_1029	COG2885	chlorophyll binding
CH47_1029	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH47_103	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH47_1030	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH47_1031	COG3070	regulator of competence-specific genes
CH47_1032	COG1289	transmembrane transporter activity
CH47_1033	COG3304	Inner membrane component domain
CH47_1034	COG0210	DNA helicase
CH47_1035	COG1803	Methylglyoxal synthase
CH47_1036	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CH47_1037	COG1832	CoA-binding protein
CH47_1038	COG3785	DNA binding
CH47_1039	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH47_1042	COG1254	Belongs to the acylphosphatase family
CH47_1043	COG2920	part of a sulfur-relay system
CH47_1045	COG3916	Acyl-homoserine-lactone synthase
CH47_1046	COG2771	luxR family
CH47_1048	COG3263	regulation of cellular component size
CH47_105	COG1982	Orn Lys Arg decarboxylase major
CH47_1051	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH47_1052	COG2943	transferase activity, transferring hexosyl groups
CH47_1053	COG5645	(Lipo)protein
CH47_1055	COG3104	oligopeptide transport
CH47_1056	COG2814	Major facilitator Superfamily
CH47_1057	COG2259	Doxx family
CH47_1058	COG1560	Kdo2-lipid A biosynthetic process
CH47_1066	COG0628	permease
CH47_107	COG0741	lytic transglycosylase activity
CH47_1071	COG0418	dihydroorotase activity
CH47_1072	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH47_1073	COG2801	Transposase and inactivated derivatives
CH47_1076	COG1530	ribonuclease E activity
CH47_1077	COG0564	pseudouridine synthase activity
CH47_1079	COG1399	metal-binding, possibly nucleic acid-binding protein
CH47_108	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CH47_1080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH47_1081	COG0416	fatty acid biosynthetic process
CH47_1082	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CH47_1083	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH47_1084	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_1086	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH47_1087	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH47_1088	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH47_1089	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH47_109	COG1194	a g-specific adenine glycosylase
CH47_1090	COG0470	DNA polymerase III
CH47_1091	COG0084	hydrolase, TatD family'
CH47_1092	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_1092	COG1263	PTS System
CH47_1095	COG0641	radical SAM
CH47_1097	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH47_1098	COG0537	adenosine 5'-monophosphoramidase activity
CH47_1099	COG5633	Lipoprotein
CH47_11	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH47_110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH47_1100	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH47_1101	COG0510	thiamine kinase activity
CH47_1102	COG1472	Belongs to the glycosyl hydrolase 3 family
CH47_1103	COG3150	esterase
CH47_1104	COG1252	NADH dehydrogenase
CH47_1105	COG3134	Outer membrane lipoprotein
CH47_1106	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH47_1107	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH47_1109	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH47_111	COG3171	Protein conserved in bacteria
CH47_1110	COG1940	carbohydrate kinase activity
CH47_1111	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CH47_1113	COG2850	peptidyl-arginine hydroxylation
CH47_1115	COG0745	RESPONSE REGULATOR receiver
CH47_1117	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH47_1118	COG2915	High frequency lysogenization protein hflD homolog
CH47_1119	COG0482	sulfurtransferase activity
CH47_112	COG2066	Belongs to the glutaminase family
CH47_1121	COG1187	pseudouridine synthase activity
CH47_1122	COG0538	isocitrate dehydrogenase activity
CH47_1130	COG0840	transmembrane signaling receptor activity
CH47_1135	COG0702	epimerase
CH47_1136	COG1733	regulation of RNA biosynthetic process
CH47_114	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH47_1142	COG3755	Protein conserved in bacteria
CH47_1146	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH47_1148	COG3706	GGDEF domain
CH47_1148	COG5001	Diguanylate cyclase
CH47_1148	COG4251	negative regulation of phosphorylation
CH47_1148	COG2203	Gaf domain
CH47_115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH47_1150	COG1132	(ABC) transporter
CH47_1154	COG2207	Transcriptional regulator
CH47_116	COG1872	DUF167
CH47_1161	COG1113	amino acid transport
CH47_1164	COG1278	Cold shock
CH47_1166	COG0768	penicillin binding
CH47_1167	COG2226	methyltransferase
CH47_1169	COG3447	MASE1 domain protein
CH47_1169	COG5001	Diguanylate cyclase
CH47_1169	COG5002	protein histidine kinase activity
CH47_117	COG0762	integral membrane protein
CH47_1171	COG1971	Probably functions as a manganese efflux pump
CH47_1172	COG4811	Protein of unknown function (DUF986)
CH47_1173	COG3716	PTS system mannose fructose sorbose family IID component
CH47_1174	COG3715	PTS system
CH47_1175	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_1175	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_1176	COG1253	flavin adenine dinucleotide binding
CH47_1178	COG1760	l-serine dehydratase
CH47_1179	COG0494	nUDIX hydrolase
CH47_118	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH47_1181	COG3140	Belongs to the UPF0181 family
CH47_1182	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH47_1183	COG0513	Belongs to the DEAD box helicase family
CH47_1184	COG3141	response to X-ray
CH47_1187	COG1770	oligopeptidase
CH47_1188	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH47_119	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH47_1193	COG1528	Iron-storage protein
CH47_1194	COG2372	response to copper ion
CH47_1195	COG1276	copper resistance
CH47_1197	COG4974	Belongs to the 'phage' integrase family
CH47_12	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH47_120	COG2805	Type II/IV secretion system protein
CH47_1209	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH47_1218	COG3077	Addiction module antitoxin, RelB DinJ family
CH47_1219	COG3041	Addiction module toxin RelE StbE family
CH47_122	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH47_123	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH47_1237	COG4695	Portal protein
CH47_124	COG1678	Uncharacterized ACR, COG1678
CH47_1242	COG2963	transposase activity
CH47_1243	COG2801	Transposase and inactivated derivatives
CH47_125	COG0189	ligase activity
CH47_1253	COG2801	Transposase and inactivated derivatives
CH47_126	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH47_1261	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH47_1262	COG0322	excinuclease ABC activity
CH47_1263	COG2197	response regulator
CH47_1265	COG3136	membrane protein required for alginate biosynthesis
CH47_127	COG2356	endonuclease I
CH47_1275	COG3772	lysozyme
CH47_1276	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CH47_1277	COG1187	pseudouridine synthase activity
CH47_1278	COG0786	glutamate:sodium symporter activity
CH47_1278	COG0786	glutamate:sodium symporter activity
CH47_128	COG3091	SprT-like family
CH47_1282	COG0668	transmembrane transport
CH47_1283	COG0625	glutathione transferase activity
CH47_1289	COG5001	Diguanylate cyclase
CH47_1289	COG4251	negative regulation of phosphorylation
CH47_1289	COG2203	Gaf domain
CH47_1289	COG3706	GGDEF domain
CH47_129	COG0640	Transcriptional regulator
CH47_1296	COG2814	Major facilitator Superfamily
CH47_1298	COG3008	intermembrane lipid transfer
CH47_1299	COG2995	paraquat-inducible protein a
CH47_1300	COG1956	GAF domain-containing protein
CH47_1302	COG0793	Belongs to the peptidase S41A family
CH47_1303	COG0501	Belongs to the peptidase M48B family
CH47_1309	COG2814	Major facilitator Superfamily
CH47_1310	COG0823	Involved in the tonB-independent uptake of proteins
CH47_1312	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH47_1314	COG1988	membrane-bound metal-dependent
CH47_1315	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH47_1316	COG1653	transport
CH47_1317	COG3842	ATPase activity
CH47_1318	COG0395	ABC-type sugar transport system, permease component
CH47_1319	COG1175	transmembrane transport
CH47_132	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH47_1321	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_1322	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH47_1323	COG1917	Cupin 2, conserved barrel domain protein
CH47_1324	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH47_1326	COG0427	acetyl-CoA hydrolase
CH47_1327	COG0583	DNA-binding transcription factor activity
CH47_1328	COG1024	Enoyl-CoA hydratase
CH47_1329	COG1703	isobutyryl-CoA mutase activity
CH47_133	COG1166	arginine decarboxylase activity
CH47_1330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH47_1330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH47_1332	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH47_1333	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH47_1334	COG1121	(ABC) transporter
CH47_1335	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH47_1345	COG4249	Peptidase C14 caspase catalytic subunit p20
CH47_1346	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH47_1347	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH47_1348	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH47_1349	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CH47_135	COG0501	Belongs to the peptidase M48B family
CH47_1350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CH47_1352	COG0776	regulation of translation
CH47_1353	COG2963	transposase activity
CH47_1354	COG2801	Transposase and inactivated derivatives
CH47_136	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH47_1362	COG2314	TM2 domain
CH47_1363	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH47_1363	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH47_1363	COG0506	proline dehydrogenase activity
CH47_1368	COG3157	Type VI secretion system effector, Hcp
CH47_1373	COG0655	NAD(P)H dehydrogenase (quinone) activity
CH47_1375	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH47_1376	COG2233	PERMEase
CH47_1377	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CH47_1378	COG0778	Nitroreductase
CH47_1379	COG2267	carboxylic ester hydrolase activity
CH47_1380	COG0251	oxidation-reduction process
CH47_1381	COG1335	isochorismatase
CH47_1382	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH47_1383	COG1309	transcriptional regulator
CH47_1384	COG1113	amino acid transport
CH47_1395	COG2226	methyltransferase
CH47_14	COG5001	Diguanylate cyclase
CH47_1400	COG0366	Alpha amylase catalytic
CH47_1403	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH47_1404	COG0671	phosphoesterase, PA-phosphatase related
CH47_1405	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH47_1406	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH47_1408	COG3135	benzoate transporter
CH47_1410	COG0284	orotidine-5'-phosphate decarboxylase activity
CH47_1411	COG0023	Translation Initiation Factor
CH47_1413	COG0235	Class ii aldolase
CH47_1415	COG1349	DNA-binding transcription factor activity
CH47_1416	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH47_1417	COG2879	small protein
CH47_1418	COG1966	Carbon starvation protein
CH47_1419	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH47_1420	COG0243	molybdopterin cofactor binding
CH47_1424	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH47_1426	COG4659	FMN binding
CH47_1427	COG4658	electron transport chain
CH47_1428	COG2207	Transcriptional regulator
CH47_1428	COG3708	Transcriptional regulator
CH47_1429	COG4656	Part of a membrane complex involved in electron transport
CH47_143	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH47_1431	COG4657	Part of a membrane complex involved in electron transport
CH47_1433	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH47_1437	COG2160	L-arabinose isomerase activity
CH47_1439	COG1879	ABC-type sugar transport system periplasmic component
CH47_144	COG0126	phosphoglycerate kinase activity
CH47_1441	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_1443	COG0673	inositol 2-dehydrogenase activity
CH47_1444	COG0385	Bile acid
CH47_1445	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH47_1446	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH47_1447	COG1263	PTS System
CH47_1447	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_1449	COG1609	Transcriptional regulator
CH47_145	COG0191	fructose-bisphosphate aldolase activity
CH47_1450	COG5339	Protein conserved in bacteria
CH47_1452	COG0114	fumarate hydratase activity
CH47_1457	COG2814	Major facilitator Superfamily
CH47_1458	COG0583	DNA-binding transcription factor activity
CH47_1459	COG1940	carbohydrate kinase activity
CH47_1460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH47_1465	COG1742	UPF0060 membrane protein
CH47_1466	COG4221	oxidoreductase activity
CH47_1467	COG0477	Major facilitator Superfamily
CH47_147	COG1279	arginine transmembrane transporter activity
CH47_1475	COG0625	glutathione transferase activity
CH47_1477	COG1522	sequence-specific DNA binding
CH47_1479	COG4215	(ABC) transporter
CH47_1483	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH47_1487	COG0583	DNA-binding transcription factor activity
CH47_1488	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH47_149	COG0583	DNA-binding transcription factor activity
CH47_1490	COG0483	inositol monophosphate 1-phosphatase activity
CH47_1491	COG2271	Major facilitator Superfamily
CH47_1495	COG0028	Belongs to the TPP enzyme family
CH47_1496	COG0440	acetolactate synthase activity
CH47_1497	COG1011	Hydrolase
CH47_150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH47_1501	COG0738	Major facilitator superfamily
CH47_1502	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH47_1504	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_1505	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH47_1508	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH47_1509	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH47_151	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH47_1510	COG0589	response to stress
CH47_1511	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH47_1512	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH47_1514	COG0531	amino acid
CH47_1516	COG0745	RESPONSE REGULATOR receiver
CH47_1517	COG2205	protein histidine kinase activity
CH47_1518	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH47_152	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH47_1520	COG3591	Belongs to the peptidase S1B family
CH47_1523	COG1643	Atp-dependent helicase
CH47_1525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH47_1527	COG3784	Protein of unknown function (DUF1318)
CH47_1529	COG2911	Protein conserved in bacteria
CH47_153	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH47_1530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH47_1531	COG3042	response to heat
CH47_1532	COG1285	pathogenesis
CH47_1534	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH47_1534	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH47_1534	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH47_1534	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_1535	COG2723	6-phospho-beta-galactosidase activity
CH47_1536	COG2190	(PTS) system
CH47_1536	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_1536	COG1263	PTS System
CH47_1537	COG3711	transcriptional antiterminator
CH47_1538	COG0037	tRNA processing
CH47_1539	COG0598	Magnesium transport protein CorA
CH47_154	COG3079	Belongs to the UPF0149 family
CH47_1541	COG4166	transmembrane transport
CH47_1542	COG4948	Mandelate Racemase Muconate Lactonizing
CH47_1543	COG2866	Carboxypeptidase
CH47_1544	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH47_1548	COG3768	UPF0283 membrane protein
CH47_1549	COG3106	COG3106 Predicted ATPase
CH47_155	COG0006	proline dipeptidase activity
CH47_1551	COG1983	PspC domain protein
CH47_1553	COG1842	Phage shock protein A
CH47_1554	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH47_1557	COG4166	transmembrane transport
CH47_1558	COG4168	peptide transport system, permease
CH47_1559	COG4171	peptide transport system, permease
CH47_156	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH47_1561	COG4172	Belongs to the ABC transporter superfamily
CH47_1563	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH47_1563	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH47_1565	COG3104	oligopeptide transport
CH47_1569	COG0625	glutathione transferase activity
CH47_157	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH47_1571	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH47_1572	COG0259	pyridoxamine-phosphate oxidase activity
CH47_1573	COG3895	Periplasmic Protein
CH47_1574	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH47_1575	COG3133	Outer membrane lipoprotein
CH47_1576	COG1846	Transcriptional regulator
CH47_1578	COG1566	PFAM secretion protein HlyD family protein
CH47_1579	COG1289	transmembrane transporter activity
CH47_158	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH47_1580	COG4989	oxidoreductase activity
CH47_1581	COG3313	Fe-S protein
CH47_1582	COG2194	sulfuric ester hydrolase activity
CH47_1583	COG1309	transcriptional regulator
CH47_1584	COG1902	pentaerythritol trinitrate reductase activity
CH47_1585	COG0346	lactoylglutathione lyase activity
CH47_1586	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH47_1587	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH47_1588	COG0791	NLP P60 protein
CH47_1589	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH47_159	COG0509	glycine decarboxylation via glycine cleavage system
CH47_1591	COG1609	Transcriptional regulator
CH47_1592	COG0583	DNA-binding transcription factor activity
CH47_1593	COG2814	Major facilitator Superfamily
CH47_1594	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH47_1595	COG0307	riboflavin synthase, alpha
CH47_1596	COG0534	Mate efflux family protein
CH47_160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH47_160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH47_1601	COG4238	major outer membrane lipoprotein
CH47_1602	COG1388	LysM domain
CH47_1602	COG1376	ErfK ybiS ycfS ynhG family protein
CH47_1603	COG2166	iron-sulfur cluster assembly
CH47_1605	COG0719	Fe-S assembly protein
CH47_1606	COG0396	ATPase activity
CH47_1607	COG0719	Fe-S assembly protein
CH47_1608	COG0316	Belongs to the HesB IscA family
CH47_1609	COG2050	protein possibly involved in aromatic compounds catabolism
CH47_1610	COG0247	lactate metabolic process
CH47_1610	COG0277	FAD linked oxidase domain protein
CH47_1611	COG0628	permease
CH47_1612	COG0574	Belongs to the PEP-utilizing enzyme family
CH47_1612	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH47_1613	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH47_1615	COG4771	TonB-dependent receptor
CH47_1616	COG3720	iron ion transport
CH47_1617	COG4558	Periplasmic binding protein
CH47_1619	COG0095	Lipoate-protein ligase
CH47_1620	COG0791	NLP P60 protein
CH47_1621	COG2076	Multidrug Resistance protein
CH47_1622	COG2076	Multidrug Resistance protein
CH47_1623	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH47_1624	COG0726	polysaccharide deacetylase
CH47_1625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH47_1625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_1626	COG0463	Glycosyl transferase, family 2
CH47_1627	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH47_1628	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH47_1629	COG0386	Belongs to the glutathione peroxidase family
CH47_163	COG1272	protein, Hemolysin III
CH47_1630	COG4139	cobalamin transport
CH47_1632	COG0583	DNA-binding transcription factor activity
CH47_1633	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH47_1635	COG0616	signal peptide processing
CH47_1636	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_1637	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH47_1638	COG1187	pseudouridine synthase activity
CH47_1639	COG0009	L-threonylcarbamoyladenylate synthase
CH47_164	COG0354	folic acid binding
CH47_1640	COG0613	PHP domain protein
CH47_1642	COG0512	Glutamine amidotransferase of anthranilate synthase
CH47_1644	COG0134	indole-3-glycerol-phosphate synthase activity
CH47_1644	COG0135	phosphoribosylanthranilate isomerase activity
CH47_1645	COG0133	tryptophan synthase activity
CH47_1646	COG0159	tryptophan synthase activity
CH47_1648	COG3047	cAMP biosynthetic process
CH47_165	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CH47_1652	COG2917	probably involved in intracellular septation
CH47_1653	COG1607	acyl-coa hydrolase
CH47_1654	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH47_1655	COG2350	Protein conserved in bacteria
CH47_1658	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH47_1659	COG3099	Belongs to the UPF0263 family
CH47_1661	COG0444	Belongs to the ABC transporter superfamily
CH47_1662	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH47_1665	COG4166	transmembrane transport
CH47_1666	COG2095	MarC family integral membrane protein
CH47_1667	COG1454	alcohol dehydrogenase
CH47_1667	COG1012	belongs to the aldehyde dehydrogenase family
CH47_1669	COG1435	thymidine kinase activity
CH47_167	COG0745	RESPONSE REGULATOR receiver
CH47_1670	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH47_1672	COG0745	RESPONSE REGULATOR receiver
CH47_1673	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH47_1675	COG3012	SEC-C Motif Domain Protein
CH47_1676	COG0788	formyltetrahydrofolate deformylase activity
CH47_168	COG2205	protein histidine kinase activity
CH47_1680	COG0583	DNA-binding transcription factor activity
CH47_1681	COG0708	Exodeoxyribonuclease III
CH47_1682	COG0494	nUDIX hydrolase
CH47_1684	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH47_1686	COG0778	Nitroreductase
CH47_1687	COG0616	signal peptide processing
CH47_1688	COG0252	asparaginase activity
CH47_1689	COG1335	isochorismatase
CH47_169	COG4452	Inner membrane protein CreD
CH47_1690	COG3139	Protein of unknown function (DUF1315)
CH47_1691	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH47_1697	COG3713	MltA-interacting MipA family protein
CH47_1698	COG2766	serine protein kinase
CH47_1699	COG2718	Belongs to the UPF0229 family
CH47_17	COG0477	Major facilitator Superfamily
CH47_170	COG0716	FMN binding
CH47_1702	COG0583	DNA-binding transcription factor activity
CH47_1704	COG2200	EAL domain
CH47_1704	COG2202	Pas domain
CH47_1704	COG2199	diguanylate cyclase activity
CH47_1705	COG2814	Major facilitator Superfamily
CH47_1706	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH47_1707	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH47_1708	COG2719	SpoVR family
CH47_1709	COG2186	Transcriptional regulator
CH47_171	COG4974	Belongs to the 'phage' integrase family
CH47_1710	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH47_1711	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH47_1712	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH47_1718	COG0582	viral genome integration into host DNA
CH47_1719	COG2983	Belongs to the UPF0260 family
CH47_172	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH47_1720	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH47_1721	COG2951	lytic endotransglycosylase activity
CH47_1722	COG3100	YcgL domain-containing protein
CH47_1724	COG0850	regulation of cytokinetic process
CH47_1725	COG2894	cell division
CH47_1726	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH47_1727	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH47_1728	COG0318	PFAM AMP-dependent synthetase and ligase
CH47_1729	COG3065	identical protein binding
CH47_173	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH47_1731	COG1199	ATP-dependent helicase activity
CH47_1732	COG0251	oxidation-reduction process
CH47_1733	COG2076	Multidrug Resistance protein
CH47_1734	COG2076	Multidrug Resistance protein
CH47_1735	COG0800	Aldolase
CH47_1736	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH47_1737	COG1737	Transcriptional regulator
CH47_1738	COG0469	pyruvate kinase activity
CH47_1739	COG1560	Kdo2-lipid A biosynthetic process
CH47_174	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH47_1740	COG0739	heme binding
CH47_1741	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH47_1742	COG1121	(ABC) transporter
CH47_1743	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH47_1744	COG3104	oligopeptide transport
CH47_1745	COG2255	four-way junction helicase activity
CH47_1746	COG0632	four-way junction helicase activity
CH47_1747	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH47_1748	COG0217	transcriptional regulatory protein
CH47_1749	COG0494	nUDIX hydrolase
CH47_175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CH47_1751	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH47_1752	COG1335	isochorismatase
CH47_1753	COG1801	Protein of unknown function DUF72
CH47_1754	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH47_1755	COG2226	methyltransferase
CH47_1756	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH47_1757	COG3142	Participates in the control of copper homeostasis
CH47_1758	COG3102	Protein conserved in bacteria
CH47_1759	COG0018	arginyl-trna synthetase
CH47_1762	COG0728	peptidoglycan biosynthetic process
CH47_1763	COG0673	inositol 2-dehydrogenase activity
CH47_1765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH47_1768	COG0477	Major facilitator Superfamily
CH47_1770	COG3381	protein complex oligomerization
CH47_1771	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH47_1772	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH47_1776	COG3706	GGDEF domain
CH47_1777	COG0659	secondary active sulfate transmembrane transporter activity
CH47_1778	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CH47_1779	COG2912	Transglutaminase-like superfamily
CH47_1780	COG3094	Invasion gene expression up-regulator, SirB
CH47_1781	COG2890	protein-(glutamine-N5) methyltransferase activity
CH47_1782	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH47_1783	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH47_1784	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH47_1786	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH47_1788	COG0193	aminoacyl-tRNA hydrolase activity
CH47_1790	COG0012	GTP binding
CH47_1793	COG2979	Protein of unknown function (DUF533)
CH47_1799	COG1349	DNA-binding transcription factor activity
CH47_180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH47_1800	COG2222	sugar isomerase
CH47_1802	COG4942	peptidase
CH47_1806	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH47_1808	COG0402	S-adenosylhomocysteine deaminase activity
CH47_181	COG1393	Belongs to the ArsC family
CH47_1810	COG1228	amidohydrolase
CH47_1813	COG2988	succinylglutamate desuccinylase activity
CH47_1814	COG3724	N-succinylarginine dihydrolase activity
CH47_1816	COG3138	arginine N-succinyltransferase
CH47_1817	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH47_1818	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH47_1819	COG1271	oxidase subunit
CH47_182	COG4319	ketosteroid isomerase
CH47_1820	COG1294	oxidase, subunit
CH47_1821	COG3850	Histidine kinase
CH47_1822	COG0583	DNA-binding transcription factor activity
CH47_1823	COG2814	Major facilitator Superfamily
CH47_1825	COG0387	Pfam Sodium calcium exchanger
CH47_1826	COG1702	phosphate starvation-inducible protein PhoH
CH47_1828	COG3658	cytochrome
CH47_1829	COG1215	transferase activity, transferring glycosyl groups
CH47_183	COG3706	GGDEF domain
CH47_1830	COG1649	PFAM Uncharacterised BCR, COG1649
CH47_1830	COG0726	polysaccharide deacetylase
CH47_1831	COG0457	Tetratricopeptide repeat
CH47_1832	COG0006	proline dipeptidase activity
CH47_1833	COG4114	ferric iron reductase
CH47_1834	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH47_1839	COG0577	efflux transmembrane transporter activity
CH47_1839	COG1136	(ABC) transporter
CH47_184	COG1522	sequence-specific DNA binding
CH47_1841	COG1136	(ABC) transporter
CH47_1841	COG0577	efflux transmembrane transporter activity
CH47_1844	COG0672	)-iron permease
CH47_1847	COG2066	Belongs to the glutaminase family
CH47_1848	COG3622	Belongs to the hyi family
CH47_1849	COG0235	Class ii aldolase
CH47_1850	COG3395	kinase activity
CH47_1851	COG1349	DNA-binding transcription factor activity
CH47_1852	COG3290	protein histidine kinase activity
CH47_1853	COG4565	transcriptional regulatory protein
CH47_1854	COG3493	citrate carrier protein
CH47_1859	COG2223	nitrite transmembrane transporter activity
CH47_1860	COG0561	phosphatase activity
CH47_1864	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH47_1866	COG1191	sigma factor activity
CH47_187	COG2271	Major facilitator Superfamily
CH47_1875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH47_1876	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH47_1879	COG1677	Flagellar hook-basal body complex protein FliE
CH47_188	COG1609	Transcriptional regulator
CH47_1881	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH47_1882	COG1317	bacterial-type flagellum organization
CH47_1884	COG2882	bacterial-type flagellum organization
CH47_1886	COG1580	Controls the rotational direction of flagella during chemotaxis
CH47_189	COG0484	heat shock protein binding
CH47_1890	COG1338	Plays a role in the flagellum-specific transport system
CH47_1894	COG1256	bacterial-type flagellum assembly
CH47_1898	COG4786	Flagellar basal body rod
CH47_1900	COG1749	Flagellar hook protein flgE
CH47_1901	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH47_1902	COG1558	bacterial-type flagellum-dependent cell motility
CH47_1903	COG1815	bacterial-type flagellum-dependent cell motility
CH47_1905	COG2747	anti-sigma28 factor FlgM
CH47_1906	COG3418	PFAM FlgN family protein
CH47_1909	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH47_191	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_1910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH47_1912	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH47_1913	COG0745	RESPONSE REGULATOR receiver
CH47_1915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH47_1916	COG0840	transmembrane signaling receptor activity
CH47_1917	COG0840	transmembrane signaling receptor activity
CH47_1918	COG0835	chemotaxis
CH47_1919	COG0643	Histidine kinase
CH47_1919	COG2198	Histidine kinase
CH47_192	COG1733	regulation of RNA biosynthetic process
CH47_1920	COG1360	Flagellar Motor Protein
CH47_1924	COG0589	response to stress
CH47_1925	COG2130	NADP-dependent
CH47_1927	COG1285	pathogenesis
CH47_1929	COG0840	transmembrane signaling receptor activity
CH47_193	COG0288	reversible hydration of carbon dioxide
CH47_1932	COG1278	Cold shock
CH47_1933	COG1609	Transcriptional regulator
CH47_1934	COG3250	beta-galactosidase activity
CH47_1935	COG3385	transposase activity
CH47_1936	COG3385	transposase activity
CH47_1937	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_1937	COG0604	alcohol dehydrogenase
CH47_1937	COG3321	synthase
CH47_1943	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH47_1945	COG3121	Chaperone
CH47_1947	COG1070	Carbohydrate kinase
CH47_1948	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH47_1950	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_1951	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_1952	COG1129	ABC transporter
CH47_1954	COG3228	Belongs to the MtfA family
CH47_1956	COG0582	viral genome integration into host DNA
CH47_1957	COG0582	viral genome integration into host DNA
CH47_1958	COG1169	isochorismate synthase
CH47_1959	COG2814	Major facilitator Superfamily
CH47_1960	COG1132	(ABC) transporter
CH47_1963	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH47_1963	COG2226	methyltransferase
CH47_1963	COG3433	isochorismatase activity
CH47_1966	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CH47_1967	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH47_1973	COG2801	Transposase and inactivated derivatives
CH47_1975	COG2801	Transposase and inactivated derivatives
CH47_1976	COG2963	transposase activity
CH47_1983	COG3122	Protein conserved in bacteria
CH47_1985	COG2814	Major facilitator Superfamily
CH47_1988	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH47_199	COG2165	general secretion pathway protein
CH47_1991	COG0471	metal ion transport
CH47_1994	COG3051	citrate lyase alpha subunit
CH47_1995	COG2301	Belongs to the HpcH HpaI aldolase family
CH47_1996	COG3052	prosthetic group binding
CH47_1997	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH47_1998	COG3290	protein histidine kinase activity
CH47_1999	COG4565	transcriptional regulatory protein
CH47_2	COG5557	Pfam Polysulphide reductase, NrfD
CH47_20	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH47_2002	COG2271	Major facilitator Superfamily
CH47_2003	COG1840	ABC-type Fe3 transport system, periplasmic component
CH47_2005	COG3842	ATPase activity
CH47_2008	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_2008	COG2205	protein histidine kinase activity
CH47_2013	COG3121	Chaperone
CH47_2020	COG0835	chemotaxis
CH47_2020	COG0784	Response regulator, receiver
CH47_2022	COG1349	DNA-binding transcription factor activity
CH47_2023	COG0561	phosphatase activity
CH47_2024	COG0352	thiamine-phosphate diphosphorylase activity
CH47_2026	COG0534	Mate efflux family protein
CH47_2027	COG0137	argininosuccinate synthase activity
CH47_2032	COG3501	Rhs element vgr protein
CH47_2041	COG3188	usher protein
CH47_2042	COG3121	Chaperone
CH47_205	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH47_2054	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH47_2058	COG1492	cobalamin metabolic process
CH47_2068	COG2875	Belongs to the precorrin methyltransferase family
CH47_2070	COG2241	protein methyltransferase activity
CH47_2071	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH47_2073	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH47_2077	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH47_208	COG0840	transmembrane signaling receptor activity
CH47_2084	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CH47_2092	COG4656	Part of a membrane complex involved in electron transport
CH47_2094	COG4810	utilization protein
CH47_2096	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH47_2097	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH47_2097	COG1648	precorrin-2 dehydrogenase activity
CH47_2098	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH47_2100	COG2197	response regulator
CH47_2102	COG1879	ABC-type sugar transport system periplasmic component
CH47_2104	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_2106	COG2926	Belongs to the UPF0265 family
CH47_2107	COG1289	transmembrane transporter activity
CH47_2108	COG1022	Amp-dependent synthetase and ligase
CH47_2108	COG3320	Male sterility
CH47_2109	COG2925	Exonuclease
CH47_2110	COG0531	amino acid
CH47_2112	COG0371	Dehydrogenase
CH47_2113	COG1129	ABC transporter
CH47_2114	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_2115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_2116	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH47_2118	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH47_2119	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH47_2119	COG0131	Imidazoleglycerol-phosphate dehydratase
CH47_212	COG0583	DNA-binding transcription factor activity
CH47_2120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CH47_2121	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH47_2122	COG0107	imidazoleglycerol-phosphate synthase activity
CH47_2123	COG0140	phosphoribosyl-ATP diphosphatase activity
CH47_2123	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH47_2124	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH47_2127	COG3385	transposase activity
CH47_2128	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH47_2129	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH47_213	COG2814	Major facilitator Superfamily
CH47_2130	COG1253	flavin adenine dinucleotide binding
CH47_2131	COG3069	C4-dicarboxylate transmembrane transporter activity
CH47_2132	COG2982	Protein involved in outer membrane biogenesis
CH47_2133	COG0717	Belongs to the dCTP deaminase family
CH47_2134	COG0572	uridine kinase
CH47_2135	COG0489	protein tyrosine kinase activity
CH47_2136	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH47_2136	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH47_214	COG0019	diaminopimelate decarboxylase activity
CH47_2140	COG2814	Major facilitator Superfamily
CH47_2141	COG1380	Effector of murein hydrolase LrgA
CH47_2142	COG1346	cytolysis
CH47_2145	COG0281	malic enzyme
CH47_2146	COG2949	membrane
CH47_2147	COG0298	carbon dioxide binding
CH47_2148	COG0375	protein maturation
CH47_2149	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH47_215	COG1609	Transcriptional regulator
CH47_2150	COG0651	ATP synthesis coupled electron transport
CH47_2151	COG0650	Formate hydrogenlyase subunit 4
CH47_2152	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH47_2153	COG4237	Hydrogenase 4 membrane
CH47_2154	COG0651	ATP synthesis coupled electron transport
CH47_2155	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH47_2155	COG3261	NADH dehydrogenase
CH47_2156	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_2157	COG3260	NADH ubiquinone oxidoreductase 20
CH47_2159	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH47_2160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH47_2161	COG3383	formate dehydrogenase (NAD+) activity
CH47_2162	COG3604	Transcriptional regulator
CH47_2163	COG2116	formate transmembrane transporter activity
CH47_2168	COG2311	Membrane
CH47_2169	COG0302	gtp cyclohydrolase
CH47_217	COG0204	Acyl-transferase
CH47_217	COG0318	PFAM AMP-dependent synthetase and ligase
CH47_2170	COG0477	Major facilitator Superfamily
CH47_2171	COG0583	DNA-binding transcription factor activity
CH47_2178	COG0577	efflux transmembrane transporter activity
CH47_2178	COG1136	(ABC) transporter
CH47_218	COG0477	Major facilitator Superfamily
CH47_2181	COG0303	'Molybdopterin
CH47_2182	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH47_2183	COG3397	chitin binding
CH47_2184	COG0488	(ABC) transporter
CH47_2188	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH47_219	COG0667	Aldo Keto reductase
CH47_2191	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CH47_2194	COG4106	trans-aconitate 2-methyltransferase activity
CH47_2195	COG0783	Belongs to the Dps family
CH47_2196	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH47_2197	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_2198	COG0765	amino acid transport
CH47_2199	COG1126	abc transporter atp-binding protein
CH47_22	COG1609	Transcriptional regulator
CH47_220	COG0861	Integral membrane protein TerC family
CH47_2201	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH47_2206	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH47_2207	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH47_221	COG3066	DNA modification
CH47_2211	COG0697	spore germination
CH47_2212	COG0583	DNA-binding transcription factor activity
CH47_2215	COG1174	glycine betaine transport
CH47_2216	COG1125	glycine betaine transport
CH47_2217	COG1174	glycine betaine transport
CH47_2218	COG1732	Glycine betaine
CH47_222	COG1051	belongs to the nudix hydrolase family
CH47_2221	COG2897	thiosulfate sulfurtransferase activity
CH47_2223	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CH47_2227	COG4807	Protein conserved in bacteria
CH47_2230	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH47_2232	COG2261	transglycosylase associated protein
CH47_2234	COG1403	HNH endonuclease
CH47_2236	COG0277	FAD linked oxidase domain protein
CH47_2237	COG1686	Belongs to the peptidase S11 family
CH47_224	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH47_2240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH47_2243	COG0513	Belongs to the DEAD box helicase family
CH47_2244	COG1309	transcriptional regulator
CH47_2245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_2246	COG1131	(ABC) transporter
CH47_2247	COG0842	Transport permease protein
CH47_2248	COG0842	Transport permease protein
CH47_2249	COG0670	Belongs to the BI1 family
CH47_225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CH47_2250	COG0314	molybdopterin synthase activity
CH47_2251	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH47_2252	COG0315	cyclic pyranopterin monophosphate synthase activity
CH47_2253	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH47_2254	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH47_2255	COG4628	conserved protein (DUF2132)
CH47_2256	COG0556	nucleotide-excision repair
CH47_2258	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH47_2259	COG2226	methyltransferase
CH47_2260	COG0156	8-amino-7-oxononanoate synthase activity
CH47_2261	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH47_2263	COG2706	6-phosphogluconolactonase activity
CH47_2264	COG0561	phosphatase activity
CH47_2266	COG4149	molybdate abc transporter
CH47_2267	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH47_2269	COG2005	Transcriptional regulator
CH47_2269	COG3585	molybdate ion transport
CH47_2270	COG1119	ATPase activity
CH47_2272	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH47_2273	COG1085	galactose-1-phosphate uridylyltransferase
CH47_2274	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH47_2275	COG2017	converts alpha-aldose to the beta-anomer
CH47_2280	COG0588	phosphoglycerate mutase activity
CH47_2281	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH47_2282	COG1230	cation diffusion facilitator family transporter
CH47_2284	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH47_2289	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH47_2290	COG2885	chlorophyll binding
CH47_2291	COG0823	Involved in the tonB-independent uptake of proteins
CH47_2292	COG3064	Membrane
CH47_2292	COG3064	Membrane
CH47_2293	COG0848	biopolymer transport protein
CH47_2294	COG0811	peptide transport
CH47_2295	COG0824	Thioesterase
CH47_2296	COG3790	cyd operon protein YbgE
CH47_2297	COG4890	Cyd operon protein YbgT
CH47_2298	COG1294	oxidase, subunit
CH47_2299	COG1271	oxidase subunit
CH47_23	COG0477	Major facilitator Superfamily
CH47_230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH47_2300	COG0737	Belongs to the 5'-nucleotidase family
CH47_2301	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH47_2302	COG0045	succinate-CoA ligase (ADP-forming) activity
CH47_2303	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH47_2304	COG0567	Dehydrogenase, E1 component
CH47_2306	COG1053	succinate dehydrogenase
CH47_2307	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH47_2308	COG2009	succinate dehydrogenase
CH47_231	COG1025	Belongs to the peptidase M16 family
CH47_2310	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CH47_2313	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH47_2314	COG1984	allophanate hydrolase subunit 2
CH47_2315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH47_2316	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH47_2317	COG5212	phosphodiesterase
CH47_2319	COG3272	Protein of unknown function (DUF1722)
CH47_232	COG1074	ATP-dependent DNA helicase activity
CH47_2321	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CH47_2322	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH47_2323	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH47_2324	COG2205	protein histidine kinase activity
CH47_2325	COG0745	RESPONSE REGULATOR receiver
CH47_2328	COG0033	Phosphoglucomutase
CH47_2329	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH47_233	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH47_2330	COG0596	Alpha beta hydrolase
CH47_2333	COG0840	transmembrane signaling receptor activity
CH47_2335	COG0735	belongs to the Fur family
CH47_2339	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH47_234	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH47_234	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH47_2340	COG2190	(PTS) system
CH47_2340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_2340	COG1263	PTS System
CH47_2341	COG0363	glucosamine-6-phosphate deaminase activity
CH47_2342	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH47_2343	COG1940	carbohydrate kinase activity
CH47_2343	COG1846	Transcriptional regulator
CH47_2344	COG0647	UMP catabolic process
CH47_2345	COG0367	asparagine synthase
CH47_235	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH47_2352	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH47_2353	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH47_2354	COG1702	phosphate starvation-inducible protein PhoH
CH47_2355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH47_2356	COG4535	Mg2 and Co2 transporter CorC
CH47_2357	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH47_2360	COG0765	amino acid transport
CH47_2361	COG0765	amino acid transport
CH47_2362	COG1126	abc transporter atp-binding protein
CH47_2363	COG2888	peptidyl-tyrosine sulfation
CH47_2364	COG0495	leucyl-tRNA aminoacylation
CH47_2365	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH47_2366	COG1466	dna polymerase III delta subunit
CH47_2367	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH47_2368	COG0799	negative regulation of ribosome biogenesis
CH47_2370	COG0768	penicillin binding
CH47_2371	COG0772	Belongs to the SEDS family
CH47_2372	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH47_2373	COG1686	Belongs to the peptidase S11 family
CH47_2374	COG2921	Belongs to the UPF0250 family
CH47_2375	COG0321	lipoyl(octanoyl) transferase activity
CH47_2376	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH47_2377	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH47_2378	COG3706	GGDEF domain
CH47_2379	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH47_2380	COG1278	Cold shock
CH47_2381	COG1278	Cold shock
CH47_2382	COG2197	response regulator
CH47_2384	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH47_2387	COG5265	(ABC) transporter
CH47_2390	COG2986	histidine ammonia-lyase
CH47_2391	COG2850	peptidyl-arginine hydroxylation
CH47_2394	COG5002	protein histidine kinase activity
CH47_2398	COG0656	L-ascorbic acid biosynthetic process
CH47_240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH47_2401	COG1902	pentaerythritol trinitrate reductase activity
CH47_2406	COG2963	transposase activity
CH47_241	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH47_2410	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH47_2411	COG1216	Glycosyl transferase, family 2
CH47_2412	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH47_2413	COG5301	cellulose 1,4-beta-cellobiosidase activity
CH47_242	COG2166	iron-sulfur cluster assembly
CH47_2420	COG0582	viral genome integration into host DNA
CH47_2422	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH47_2423	COG2501	S4 domain
CH47_2424	COG0215	cysteine-tRNA ligase activity
CH47_2425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH47_2426	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH47_2427	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH47_2428	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH47_2429	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH47_243	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH47_2430	COG4181	ATPase activity
CH47_2431	COG2755	lipolytic protein G-D-S-L family
CH47_2432	COG0300	oxidoreductase activity
CH47_2433	COG3118	belongs to the thioredoxin family
CH47_2434	COG0330	HflC and HflK could
CH47_2435	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH47_2436	COG0789	Transcriptional regulator
CH47_2437	COG2217	Heavy metal translocating P-type atpase
CH47_2438	COG3735	TraB family
CH47_2439	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH47_2441	COG0737	Belongs to the 5'-nucleotidase family
CH47_2442	COG2223	nitrite transmembrane transporter activity
CH47_2443	COG4651	solute:proton antiporter activity
CH47_2443	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH47_2444	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH47_2447	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH47_2449	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_245	COG0583	DNA-binding transcription factor activity
CH47_2450	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH47_2451	COG0438	transferase activity, transferring glycosyl groups
CH47_2453	COG1216	Glycosyl transferase, family 2
CH47_2459	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_246	COG2363	Small membrane protein
CH47_2462	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CH47_2463	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH47_2464	COG0563	adenylate kinase activity
CH47_2465	COG0326	Molecular chaperone. Has ATPase activity
CH47_2466	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH47_2467	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH47_2469	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH47_247	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH47_2470	COG2832	Protein of unknown function (DUF454)
CH47_2472	COG1196	nuclear chromosome segregation
CH47_2472	COG3264	Mechanosensitive ion channel
CH47_2473	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH47_2474	COG1309	transcriptional regulator
CH47_2475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_2476	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH47_2478	COG3457	Alanine racemase
CH47_2479	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH47_248	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH47_2482	COG0254	rRNA binding
CH47_2483	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH47_2484	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH47_2485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH47_249	COG1611	Belongs to the LOG family
CH47_2491	COG3695	enzyme binding
CH47_2492	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH47_2493	COG1946	Acyl-CoA thioesterase
CH47_2494	COG0004	ammonium transporteR
CH47_2495	COG0347	Belongs to the P(II) protein family
CH47_2496	COG1132	(ABC) transporter
CH47_2497	COG1132	(ABC) transporter
CH47_2498	COG1522	sequence-specific DNA binding
CH47_25	COG4607	ABC-type enterochelin transport system periplasmic component
CH47_250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH47_250	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH47_2500	COG0561	phosphatase activity
CH47_2501	COG4533	DNA binding
CH47_2502	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH47_2503	COG0824	Thioesterase
CH47_2504	COG1555	photosystem II stabilization
CH47_2505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH47_2507	COG0776	regulation of translation
CH47_2508	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH47_2509	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH47_2510	COG0740	serine-type endopeptidase activity
CH47_2511	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH47_2512	COG0271	Belongs to the BolA IbaG family
CH47_2513	COG3056	Lipoprotein
CH47_2514	COG2223	nitrite transmembrane transporter activity
CH47_2516	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH47_2517	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH47_2518	COG1845	cytochrome c oxidase, subunit III
CH47_2519	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH47_252	COG3098	single-species biofilm formation
CH47_2520	COG0109	protoheme IX farnesyltransferase activity
CH47_2521	COG2814	Major facilitator Superfamily
CH47_2522	COG1666	GTP binding
CH47_2523	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH47_2524	COG0693	protein deglycase activity
CH47_2525	COG0301	tRNA thio-modification
CH47_2525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH47_2527	COG0142	geranyltranstransferase activity
CH47_2528	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH47_2529	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH47_253	COG0564	pseudouridine synthase activity
CH47_2530	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH47_2531	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH47_2532	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH47_2533	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH47_2533	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH47_2534	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH47_2535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH47_2536	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH47_2537	COG1862	Preprotein translocase
CH47_2538	COG0343	queuine tRNA-ribosyltransferase activity
CH47_2540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CH47_2541	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH47_2542	COG0450	alkyl hydroperoxide reductase
CH47_2545	COG0366	Alpha amylase catalytic
CH47_2547	COG1114	Component of the transport system for branched-chain amino acids
CH47_2549	COG5002	protein histidine kinase activity
CH47_2550	COG0745	RESPONSE REGULATOR receiver
CH47_2551	COG0420	3'-5' exonuclease activity
CH47_2552	COG0419	ATPase involved in DNA repair
CH47_2553	COG1940	carbohydrate kinase activity
CH47_2554	COG2974	May be involved in recombination
CH47_2555	COG3123	guanosine phosphorylase activity
CH47_2556	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH47_256	COG2171	N-acyltransferase activity
CH47_2561	COG2226	methyltransferase
CH47_2564	COG3459	Glycosyltransferase 36 associated
CH47_2567	COG1486	melibiose metabolic process
CH47_2569	COG2188	Transcriptional regulator
CH47_257	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH47_2570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH47_2571	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH47_2574	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CH47_2575	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH47_2576	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH47_2579	COG2964	Protein conserved in bacteria
CH47_258	COG0024	Methionine aminopeptidase
CH47_2580	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH47_2582	COG2991	Protein conserved in bacteria
CH47_2583	COG1477	protein flavinylation
CH47_2584	COG2871	sodium ion transport
CH47_2585	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH47_2586	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH47_2587	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH47_2588	COG1805	sodium ion transport
CH47_2589	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH47_259	COG0052	Belongs to the universal ribosomal protein uS2 family
CH47_2590	COG0121	glutamine amidotransferase
CH47_2591	COG3034	peptidoglycan biosynthetic process
CH47_2592	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH47_2593	COG1960	acyl-CoA dehydrogenase activity
CH47_2594	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH47_2596	COG2831	hemolysin activation secretion protein
CH47_2597	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH47_2598	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CH47_2599	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH47_260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH47_2600	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH47_2601	COG0235	Class ii aldolase
CH47_2602	COG0436	Aminotransferase
CH47_2604	COG2814	Major facilitator Superfamily
CH47_2605	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH47_2607	COG1846	Transcriptional regulator
CH47_2608	COG1538	Outer membrane efflux protein
CH47_2609	COG1566	PFAM secretion protein HlyD family protein
CH47_261	COG0528	UMP kinase activity
CH47_2610	COG2814	Major facilitator Superfamily
CH47_2613	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH47_2614	COG3118	belongs to the thioredoxin family
CH47_2616	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH47_2616	COG1042	CoA-binding domain protein
CH47_2616	COG0045	succinate-CoA ligase (ADP-forming) activity
CH47_2617	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH47_262	COG0233	cytoplasmic translational termination
CH47_2620	COG2801	Transposase and inactivated derivatives
CH47_2621	COG5544	Lipoprotein
CH47_2622	COG3385	transposase activity
CH47_2628	COG0542	response to heat
CH47_263	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH47_2630	COG0564	pseudouridine synthase activity
CH47_2631	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH47_2632	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH47_2633	COG1605	Chorismate mutase
CH47_2633	COG0077	Prephenate dehydratase
CH47_2634	COG1605	Chorismate mutase
CH47_2634	COG0287	Prephenate dehydrogenase
CH47_2635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH47_2636	COG3279	Response regulator of the LytR AlgR family
CH47_2637	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH47_2638	COG3137	Salt-induced outer membrane protein
CH47_2639	COG0335	large ribosomal subunit rRNA binding
CH47_264	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CH47_2640	COG0336	Belongs to the RNA methyltransferase TrmD family
CH47_2641	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH47_2642	COG0228	four-way junction DNA binding
CH47_2643	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH47_2644	COG4137	Cytochrome C assembly protein
CH47_2645	COG4536	flavin adenine dinucleotide binding
CH47_2646	COG1854	S-ribosylhomocysteine lyase activity
CH47_2647	COG2918	glutathione biosynthetic process
CH47_2648	COG1238	metal cluster binding
CH47_2649	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH47_265	COG0575	Belongs to the CDS family
CH47_2654	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH47_2655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH47_2656	COG2137	regulation of response to DNA damage stimulus
CH47_2657	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH47_266	COG0750	zinc metalloprotease
CH47_2662	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH47_2663	COG3958	Transketolase
CH47_2664	COG3959	Transketolase, thiamine diphosphate binding domain
CH47_2665	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_2666	COG1129	ABC transporter
CH47_2671	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH47_2671	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH47_2678	COG0640	Transcriptional regulator
CH47_2679	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH47_268	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH47_2681	COG3665	Urea carboxylase-associated protein
CH47_2682	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH47_2683	COG1126	abc transporter atp-binding protein
CH47_2684	COG0765	amino acid transport
CH47_2687	COG3048	D-serine ammonia-lyase activity
CH47_2689	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH47_269	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH47_2690	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_2694	COG1538	Outer membrane efflux protein
CH47_2696	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_27	COG4605	iron ion homeostasis
CH47_270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH47_2702	COG3539	Fimbrial protein
CH47_2703	COG3539	Fimbrial protein
CH47_2705	COG3121	Chaperone
CH47_2706	COG3188	usher protein
CH47_271	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH47_2712	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH47_2713	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH47_2714	COG4942	peptidase
CH47_2714	COG1388	LysM domain
CH47_2715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH47_2716	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH47_2717	COG0585	pseudouridine synthase activity
CH47_2718	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH47_272	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH47_2720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH47_2722	COG0529	Catalyzes the synthesis of activated sulfate
CH47_2723	COG2895	sulfate adenylyltransferase (ATP) activity
CH47_2724	COG0175	sulfate reduction
CH47_2725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH47_2725	COG1648	precorrin-2 dehydrogenase activity
CH47_2726	COG2234	aminopeptidase activity
CH47_2729	COG0175	sulfate reduction
CH47_273	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH47_2730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH47_2731	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH47_2732	COG0720	synthase
CH47_2733	COG0602	queuosine metabolic process
CH47_2738	COG0148	phosphopyruvate hydratase activity
CH47_2739	COG0504	CTP synthase activity
CH47_274	COG0587	DNA-directed DNA polymerase activity
CH47_2740	COG3956	TIGRFAM MazG family protein
CH47_2741	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH47_2742	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH47_2743	COG4999	Histidine kinase
CH47_2743	COG3850	Histidine kinase
CH47_2743	COG3437	response regulator, receiver
CH47_2743	COG2205	protein histidine kinase activity
CH47_2744	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH47_2745	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH47_2746	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH47_2748	COG2860	membrane
CH47_2749	COG0316	Belongs to the HesB IscA family
CH47_275	COG0825	malonyl-CoA metabolic process
CH47_2751	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH47_2752	COG2223	nitrite transmembrane transporter activity
CH47_2754	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH47_2755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH47_2756	COG1120	ATPase activity
CH47_2757	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH47_2758	COG1643	Atp-dependent helicase
CH47_2759	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH47_2760	COG1489	DNA binding
CH47_2761	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH47_2764	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH47_2765	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH47_2766	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH47_2767	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH47_2768	COG0726	polysaccharide deacetylase
CH47_2769	COG0842	Transport permease protein
CH47_277	COG0346	lactoylglutathione lyase activity
CH47_2770	COG1131	(ABC) transporter
CH47_2771	COG0288	reversible hydration of carbon dioxide
CH47_2772	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH47_2773	COG2132	Multicopper oxidase
CH47_2775	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH47_2776	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH47_2778	COG0697	spore germination
CH47_2779	COG3112	Uncharacterised protein family (UPF0231)
CH47_278	COG0037	tRNA processing
CH47_2783	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH47_2784	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH47_2785	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH47_2786	COG2186	Transcriptional regulator
CH47_2787	COG1113	amino acid transport
CH47_2789	COG3725	Membrane protein required for beta-lactamase induction
CH47_2792	COG4969	Belongs to the N-Me-Phe pilin family
CH47_2793	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH47_2794	COG1459	type II secretion system
CH47_2795	COG0516	GMP reductase activity
CH47_2796	COG0237	dephospho-CoA kinase activity
CH47_2797	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CH47_2798	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH47_2799	COG0494	nUDIX hydrolase
CH47_28	COG4604	ABC transporter, ATP-binding protein
CH47_280	COG4568	rho-dependent transcription termination
CH47_2800	COG0653	protein targeting
CH47_2804	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH47_2805	COG0849	cell division
CH47_2806	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH47_2808	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH47_2809	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH47_2810	COG0772	Belongs to the SEDS family
CH47_2812	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH47_2813	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH47_2814	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH47_2815	COG0768	penicillin binding
CH47_2816	COG3116	cell division
CH47_2817	COG0275	rRNA processing
CH47_2818	COG2001	Belongs to the MraZ family
CH47_282	COG4681	YaeQ
CH47_2820	COG1609	Transcriptional regulator
CH47_2822	COG0028	Belongs to the TPP enzyme family
CH47_2823	COG1022	Amp-dependent synthetase and ligase
CH47_2826	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH47_2827	COG0473	3-isopropylmalate dehydrogenase activity
CH47_2828	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH47_2831	COG3033	Beta-eliminating lyase
CH47_2832	COG0814	amino acid
CH47_2833	COG2814	Major facilitator Superfamily
CH47_2835	COG3077	Addiction module antitoxin, RelB DinJ family
CH47_2837	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH47_2838	COG4533	DNA binding
CH47_284	COG3015	lipoprotein NlpE involved in copper resistance
CH47_2841	COG4143	(ABC) transporter
CH47_2842	COG1178	ABC-type Fe3 transport system permease component
CH47_2843	COG0586	Pfam SNARE associated Golgi protein
CH47_2845	COG0417	DNA replication proofreading
CH47_2846	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH47_2847	COG0564	pseudouridine synthase activity
CH47_2848	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH47_2849	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH47_285	COG0442	prolyl-tRNA aminoacylation
CH47_2850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH47_2851	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH47_2852	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CH47_2853	COG2967	ApaG domain
CH47_2854	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH47_2855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH47_2856	COG3610	response to peptide
CH47_2857	COG2966	Psort location CytoplasmicMembrane, score
CH47_2858	COG1280	lysine exporter protein (LysE YggA)
CH47_2859	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH47_286	COG1720	tRNA m6t6A37 methyltransferase activity
CH47_2860	COG0505	Belongs to the CarA family
CH47_2861	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH47_2862	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH47_2863	COG1047	Peptidyl-prolyl cis-trans
CH47_2864	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH47_2865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH47_2866	COG0196	riboflavin kinase activity
CH47_2867	COG0268	Binds directly to 16S ribosomal RNA
CH47_2868	COG0583	DNA-binding transcription factor activity
CH47_2869	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH47_2870	COG0484	heat shock protein binding
CH47_2872	COG1584	GPR1 FUN34 yaaH family protein
CH47_2875	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH47_2876	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH47_2877	COG3022	response to hydroperoxide
CH47_2879	COG0083	homoserine kinase activity
CH47_288	COG1464	Belongs to the NlpA lipoprotein family
CH47_2881	COG0745	RESPONSE REGULATOR receiver
CH47_2882	COG3045	CreA protein
CH47_2883	COG0406	alpha-ribazole phosphatase activity
CH47_2884	COG3708	Transcriptional regulator
CH47_2884	COG2207	Transcriptional regulator
CH47_2885	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH47_2886	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH47_2887	COG0741	lytic transglycosylase activity
CH47_2888	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH47_289	COG2011	ABC-type metal ion transport system permease component
CH47_2890	COG2199	diguanylate cyclase activity
CH47_2891	COG2885	chlorophyll binding
CH47_2892	COG0488	(ABC) transporter
CH47_2896	COG0604	alcohol dehydrogenase
CH47_2898	COG0560	Phosphoserine phosphatase
CH47_2899	COG3726	membrane protein affecting hemolysin expression
CH47_29	COG0024	Methionine aminopeptidase
CH47_2900	COG3550	peptidyl-serine autophosphorylation
CH47_2901	COG0813	purine-nucleoside phosphorylase activity
CH47_2902	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH47_2903	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH47_2904	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH47_2905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH47_2906	COG0084	hydrolase, TatD family'
CH47_2907	COG4667	esterase of the alpha-beta hydrolase superfamily
CH47_2909	COG2823	Periplasmic or secreted lipoprotein
CH47_291	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH47_2910	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH47_2911	COG0456	acetyltransferase
CH47_2912	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH47_2913	COG2813	Specifically methylates the guanine in position
CH47_2914	COG0667	Aldo Keto reductase
CH47_2915	COG0583	DNA-binding transcription factor activity
CH47_2919	COG3706	GGDEF domain
CH47_2920	COG4772	TonB-dependent receptor
CH47_2927	COG3284	Transcriptional regulator
CH47_2933	COG2192	nodulation
CH47_2935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_2935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH47_2935	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH47_2936	COG1461	Dihydroxyacetone kinase
CH47_2937	COG2376	Dihydroxyacetone kinase
CH47_2939	COG3385	transposase activity
CH47_2940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH47_2941	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_2942	COG2235	arginine
CH47_2945	COG0859	PFAM glycosyl transferase family 9
CH47_2946	COG1070	Carbohydrate kinase
CH47_2947	COG2390	Transcriptional regulator
CH47_2948	COG1129	ABC transporter
CH47_2949	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_2950	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_2951	COG1879	ABC-type sugar transport system periplasmic component
CH47_2952	COG1830	Aldolase
CH47_2953	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH47_2967	COG0454	-acetyltransferase
CH47_2971	COG3077	Addiction module antitoxin, RelB DinJ family
CH47_2974	COG0582	viral genome integration into host DNA
CH47_2976	COG0795	lipopolysaccharide-transporting ATPase activity
CH47_2977	COG0795	lipopolysaccharide-transporting ATPase activity
CH47_2978	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH47_2979	COG2927	DNA polymerase III (CHI subunit)
CH47_2982	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH47_2984	COG2731	YhcH YjgK YiaL family protein
CH47_2986	COG0601	transmembrane transport
CH47_2988	COG0444	Belongs to the ABC transporter superfamily
CH47_2989	COG4608	Belongs to the ABC transporter superfamily
CH47_2992	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH47_2993	COG0583	DNA-binding transcription factor activity
CH47_2995	COG0602	queuosine metabolic process
CH47_2998	COG2188	Transcriptional regulator
CH47_2999	COG3624	Phosphonate C-P lyase system protein PhnG
CH47_3	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH47_3000	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH47_3001	COG3626	phosphonate metabolism
CH47_3002	COG3627	carbon phosphorus lyase activity
CH47_3003	COG4107	phosphonate C-P lyase system protein PhnK
CH47_3004	COG4778	phosphonate C-P lyase system protein PhnL
CH47_3005	COG3454	Phosphonate metabolism
CH47_3006	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH47_3007	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH47_3008	COG0702	epimerase
CH47_3010	COG3787	Belongs to the UPF0306 family
CH47_3012	COG3842	ATPase activity
CH47_3013	COG0395	ABC-type sugar transport system, permease component
CH47_3015	COG1653	transport
CH47_3018	COG1982	Orn Lys Arg decarboxylase major
CH47_3019	COG0531	amino acid
CH47_3020	COG3153	acetyltransferase
CH47_3021	COG2827	Endonuclease containing a URI domain
CH47_3025	COG3681	Belongs to the UPF0597 family
CH47_3026	COG0814	amino acid
CH47_3028	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH47_3029	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_303	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH47_3030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH47_3032	COG0513	Belongs to the DEAD box helicase family
CH47_3034	COG1185	polyribonucleotide nucleotidyltransferase activity
CH47_3035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CH47_3036	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH47_3037	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH47_3040	COG0195	Participates in both transcription termination and antitermination
CH47_3041	COG0779	Required for maturation of 30S ribosomal subunits
CH47_3044	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH47_3045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CH47_3046	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH47_3047	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CH47_3048	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH47_3049	COG1534	Rna-binding protein
CH47_3050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH47_3051	COG2027	D-alanyl-D-alanine carboxypeptidase
CH47_3052	COG0745	RESPONSE REGULATOR receiver
CH47_3053	COG0642	Histidine kinase
CH47_3054	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH47_3055	COG0697	spore germination
CH47_3056	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CH47_3057	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CH47_3058	COG0142	geranyltranstransferase activity
CH47_306	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH47_3060	COG3423	Transcriptional regulator
CH47_3061	COG0039	L-malate dehydrogenase activity
CH47_3062	COG1438	arginine binding
CH47_3064	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH47_3065	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH47_3067	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH47_3068	COG2105	PFAM AIG2 family protein
CH47_3070	COG0729	surface antigen
CH47_3071	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH47_3072	COG1253	flavin adenine dinucleotide binding
CH47_3074	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH47_3075	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH47_3076	COG0737	Belongs to the 5'-nucleotidase family
CH47_3077	COG0545	Peptidyl-prolyl cis-trans isomerase
CH47_3078	COG3061	Opacity-associated protein A
CH47_3080	COG0359	binds to the 23S rRNA
CH47_3081	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH47_3082	COG0360	Binds together with S18 to 16S ribosomal RNA
CH47_3084	COG1073	alpha beta
CH47_3085	COG3650	response to hydrogen peroxide
CH47_3086	COG1960	acyl-CoA dehydrogenase activity
CH47_3087	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH47_3088	COG0557	exoribonuclease II activity
CH47_3089	COG1959	2 iron, 2 sulfur cluster binding
CH47_3090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH47_3091	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH47_3092	COG0330	HflC and HflK could
CH47_3093	COG0330	HflC and HflK could
CH47_3094	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH47_3095	COG1923	regulation of RNA biosynthetic process
CH47_3096	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH47_3097	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH47_3098	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH47_3099	COG0802	atpase or kinase
CH47_31	COG0745	RESPONSE REGULATOR receiver
CH47_3100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH47_3100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH47_3101	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH47_3105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH47_3106	COG1162	GTPase activity
CH47_3107	COG0688	phosphatidylethanolamine metabolic process
CH47_3108	COG1511	domain protein
CH47_3108	COG3264	Mechanosensitive ion channel
CH47_3109	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH47_3110	COG1053	succinate dehydrogenase
CH47_3111	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH47_3112	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH47_3113	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH47_3115	COG2076	Multidrug Resistance protein
CH47_3117	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH47_3120	COG0459	protein refolding
CH47_3121	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH47_3124	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH47_3126	COG4232	protein-disulfide reductase activity
CH47_3127	COG1929	Belongs to the glycerate kinase type-1 family
CH47_3128	COG1309	transcriptional regulator
CH47_3132	COG0667	Aldo Keto reductase
CH47_3133	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_3135	COG1882	Formate acetyltransferase
CH47_3136	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH47_3137	COG0814	amino acid
CH47_3138	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH47_314	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_3140	COG3721	Heme iron utilization protein
CH47_3144	COG3720	iron ion transport
CH47_3145	COG4558	Periplasmic binding protein
CH47_3146	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH47_3147	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH47_3148	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH47_3150	COG4774	siderophore transport
CH47_3151	COG3264	Mechanosensitive ion channel
CH47_3151	COG1511	domain protein
CH47_3152	COG2161	toxin-antitoxin pair type II binding
CH47_3153	COG0612	Peptidase, M16
CH47_3154	COG4178	(ABC) transporter
CH47_3155	COG4771	TonB-dependent receptor
CH47_3156	COG3712	iron ion homeostasis
CH47_3159	COG0425	Belongs to the sulfur carrier protein TusA family
CH47_316	COG0656	L-ascorbic acid biosynthetic process
CH47_3163	COG1301	dicarboxylic acid transport
CH47_3164	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH47_3165	COG3162	membrane
CH47_3166	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH47_317	COG0583	DNA-binding transcription factor activity
CH47_3174	COG0138	bifunctional purine biosynthesis protein purh
CH47_3175	COG0151	Belongs to the GarS family
CH47_3178	COG3068	Protein conserved in bacteria
CH47_3179	COG1515	deoxyribonuclease V activity
CH47_318	COG2814	Major facilitator Superfamily
CH47_3180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH47_3181	COG2816	NAD+ diphosphatase activity
CH47_3182	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH47_3183	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CH47_3185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH47_3186	COG2104	thiamine diphosphate biosynthetic process
CH47_3187	COG2022	thiamine diphosphate biosynthetic process
CH47_3189	COG3385	transposase activity
CH47_319	COG3021	interspecies interaction between organisms
CH47_3190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH47_3191	COG0085	RNA polymerase activity
CH47_3192	COG0222	ribosome binding
CH47_3193	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH47_3194	COG0081	regulation of translation
CH47_3195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH47_3196	COG0250	Participates in transcription elongation, termination and antitermination
CH47_3197	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH47_3198	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH47_320	COG0741	lytic transglycosylase activity
CH47_320	COG1388	LysM domain
CH47_3204	COG1072	(Pantothenic acid kinase))
CH47_3205	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CH47_3205	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CH47_3207	COG1943	Transposase
CH47_321	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH47_3214	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH47_3215	COG1739	Uncharacterized protein family UPF0029
CH47_3216	COG0006	proline dipeptidase activity
CH47_3217	COG1024	Enoyl-CoA hydratase
CH47_3217	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH47_3218	COG0183	Belongs to the thiolase family
CH47_322	COG2226	methyltransferase
CH47_3220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH47_3224	COG0805	protein transport
CH47_3225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH47_3226	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH47_3227	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH47_3229	COG2226	methyltransferase
CH47_323	COG0328	RNA-DNA hybrid ribonuclease activity
CH47_3230	COG1322	Protein conserved in bacteria
CH47_3231	COG0586	Pfam SNARE associated Golgi protein
CH47_3232	COG1966	Carbon starvation protein
CH47_3234	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CH47_3235	COG0412	Dienelactone hydrolase
CH47_3236	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH47_3238	COG0583	DNA-binding transcription factor activity
CH47_3239	COG0679	Auxin Efflux Carrier
CH47_324	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH47_3240	COG0584	glycerophosphoryl diester phosphodiesterase
CH47_3241	COG3842	ATPase activity
CH47_3242	COG0395	ABC-type sugar transport system, permease component
CH47_3243	COG1175	transmembrane transport
CH47_3244	COG1653	transport
CH47_3251	COG0410	ABC transporter
CH47_3252	COG0411	ABC transporter
CH47_3253	COG4177	L-phenylalanine transmembrane transporter activity
CH47_3254	COG0559	Belongs to the binding-protein-dependent transport system permease family
CH47_3255	COG0683	leucine binding
CH47_3258	COG2177	Part of the ABC transporter FtsEX involved in
CH47_3259	COG2884	Cell division ATP-binding protein ftsE
CH47_326	COG2113	Glycine betaine
CH47_3260	COG0552	protein localization to endoplasmic reticulum
CH47_3261	COG0742	ribosomal rna small subunit methyltransferase
CH47_3262	COG3776	membrane
CH47_3265	COG3714	YhhN family
CH47_3266	COG2217	Heavy metal translocating P-type atpase
CH47_3267	COG0425	Belongs to the sulfur carrier protein TusA family
CH47_3268	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH47_327	COG4176	ABC-type proline glycine betaine transport system permease component
CH47_3270	COG0247	lactate metabolic process
CH47_3271	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH47_3272	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH47_3273	COG2271	Major facilitator Superfamily
CH47_3274	COG0584	glycerophosphoryl diester phosphodiesterase
CH47_3275	COG0561	phosphatase activity
CH47_3276	COG2267	carboxylic ester hydrolase activity
CH47_3278	COG1280	lysine exporter protein (LysE YggA)
CH47_3279	COG0514	ATP-dependent DNA helicase (RecQ)
CH47_328	COG4175	Glycine betaine
CH47_3280	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH47_3281	COG2050	protein possibly involved in aromatic compounds catabolism
CH47_3283	COG0598	Magnesium transport protein CorA
CH47_3284	COG5564	TIM-barrel signal transduction protein
CH47_3285	COG5441	Belongs to the UPF0261 family
CH47_3287	COG0210	DNA helicase
CH47_3288	COG1011	Hydrolase
CH47_3289	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH47_3290	COG3159	Protein conserved in bacteria
CH47_3291	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH47_3292	COG5567	small periplasmic lipoprotein
CH47_3293	COG1965	Belongs to the frataxin family
CH47_3294	COG3072	Adenylate cyclase
CH47_3295	COG0181	hydroxymethylbilane synthase activity
CH47_3296	COG1587	Uroporphyrinogen-III synthase
CH47_3297	COG2959	enzyme of heme biosynthesis
CH47_3298	COG3071	HemY protein
CH47_330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH47_3304	COG1113	amino acid transport
CH47_3307	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH47_3308	COG2244	polysaccharide biosynthetic process
CH47_3309	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH47_3310	COG0456	acetyltransferase
CH47_3311	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH47_3312	COG1088	dTDP-glucose 4,6-dehydratase activity
CH47_3313	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH47_3314	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH47_3315	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH47_3316	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH47_3317	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH47_3318	COG3118	belongs to the thioredoxin family
CH47_332	COG1780	Probably involved in ribonucleotide reductase function
CH47_3320	COG0248	Ppx GppA phosphatase
CH47_3323	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH47_3325	COG3121	Chaperone
CH47_3328	COG3121	Chaperone
CH47_333	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH47_3334	COG3385	transposase activity
CH47_3335	COG3385	transposase activity
CH47_3336	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH47_3337	COG0583	DNA-binding transcription factor activity
CH47_3339	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH47_334	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH47_3340	COG0129	dihydroxy-acid dehydratase activity
CH47_3341	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH47_3342	COG3978	acetolactate synthase activity
CH47_3345	COG3085	chromosome segregation
CH47_3346	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_3347	COG0583	DNA-binding transcription factor activity
CH47_3348	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_3349	COG1129	ABC transporter
CH47_3350	COG1879	ABC-type sugar transport system periplasmic component
CH47_3358	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH47_336	COG4575	ribosome binding
CH47_3360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH47_3362	COG1309	transcriptional regulator
CH47_3364	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH47_3365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH47_3365	COG0678	peroxiredoxin activity
CH47_3366	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH47_3375	COG1629	transport
CH47_3376	COG0165	Argininosuccinate lyase
CH47_3377	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH47_3378	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH47_3381	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH47_3386	COG0527	aspartate kinase activity
CH47_3386	COG0460	homoserine dehydrogenase
CH47_3387	COG0626	cystathionine gamma-synthase activity
CH47_3388	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH47_3389	COG0254	rRNA binding
CH47_3390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH47_3391	COG1609	Transcriptional regulator
CH47_3392	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH47_3393	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH47_3394	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH47_3395	COG1575	Belongs to the MenA family. Type 1 subfamily
CH47_3396	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH47_3397	COG3074	FtsZ-dependent cytokinesis
CH47_3398	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH47_3399	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH47_34	COG3397	chitin binding
CH47_340	COG2207	Transcriptional regulator
CH47_3400	COG1494	fructose-1,6-bisphosphatase
CH47_3401	COG2814	Major facilitator Superfamily
CH47_3403	COG3152	Membrane
CH47_3405	COG0149	triose-phosphate isomerase activity
CH47_3406	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH47_3407	COG0205	6-phosphofructokinase activity
CH47_3408	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH47_3409	COG3678	ATP-independent chaperone mediated protein folding
CH47_341	COG0477	Major facilitator Superfamily
CH47_3410	COG0745	RESPONSE REGULATOR receiver
CH47_3411	COG2205	protein histidine kinase activity
CH47_3412	COG2169	Transcriptional regulator
CH47_3412	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH47_3413	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH47_3414	COG1045	serine acetyltransferase
CH47_3415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH47_3416	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH47_3417	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH47_3418	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH47_3419	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH47_3420	COG4942	peptidase
CH47_3421	COG2861	carbohydrate metabolic process
CH47_3422	COG1063	alcohol dehydrogenase
CH47_3423	COG0156	8-amino-7-oxononanoate synthase activity
CH47_3424	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_3425	COG0859	PFAM glycosyl transferase family 9
CH47_3426	COG0859	PFAM glycosyl transferase family 9
CH47_3427	COG1519	Transferase
CH47_3429	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH47_3430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH47_3431	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH47_3432	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH47_3433	COG2003	Belongs to the UPF0758 family
CH47_3434	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH47_3435	COG0756	dUTP diphosphatase activity
CH47_3436	COG1309	transcriptional regulator
CH47_3437	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH47_3438	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CH47_3439	COG1561	YicC-like family, N-terminal region
CH47_345	COG1278	Cold shock
CH47_3455	COG5001	Diguanylate cyclase
CH47_3456	COG1024	Enoyl-CoA hydratase
CH47_3457	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH47_3459	COG2860	membrane
CH47_3460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH47_3462	COG1758	RNA polymerase activity
CH47_3463	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH47_3464	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH47_3465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH47_3466	COG0786	glutamate:sodium symporter activity
CH47_3467	COG2233	PERMEase
CH47_3468	COG2982	Protein involved in outer membrane biogenesis
CH47_3474	COG3423	Transcriptional regulator
CH47_3475	COG0456	acetyltransferase
CH47_3476	COG1490	D-aminoacyl-tRNA deacylase activity
CH47_3477	COG1295	ribonuclease BN
CH47_3478	COG1011	Hydrolase
CH47_3480	COG0174	glutamine synthetase
CH47_3481	COG3852	Histidine kinase
CH47_3483	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH47_3484	COG3078	GTPase activator activity
CH47_3485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH47_3486	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH47_3486	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH47_3487	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH47_3488	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH47_3489	COG3084	Protein conserved in bacteria
CH47_3491	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH47_3496	COG2186	Transcriptional regulator
CH47_3497	COG1609	Transcriptional regulator
CH47_3498	COG0477	Major facilitator Superfamily
CH47_3499	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH47_3500	COG1879	ABC-type sugar transport system periplasmic component
CH47_3501	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH47_3503	COG1869	D-ribose catabolic process
CH47_3504	COG3158	transport of potassium into the cell
CH47_3505	COG0714	Associated with various cellular activities
CH47_3506	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH47_3508	COG2502	aspartate--ammonia ligase
CH47_3509	COG1522	sequence-specific DNA binding
CH47_351	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH47_3510	COG0716	FMN binding
CH47_3511	COG0445	tRNA wobble uridine modification
CH47_3512	COG0357	Ribosomal RNA small subunit methyltransferase G
CH47_3513	COG3312	ion transport
CH47_3514	COG0356	it plays a direct role in the translocation of protons across the membrane
CH47_3516	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH47_3517	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH47_3518	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH47_3519	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CH47_352	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH47_3520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH47_3521	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH47_3522	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH47_3523	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CH47_3525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH47_3526	COG0573	inorganic phosphate transmembrane transporter activity
CH47_3527	COG0581	inorganic phosphate transmembrane transporter activity
CH47_3529	COG0704	Plays a role in the regulation of phosphate uptake
CH47_3531	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_3532	COG0765	amino acid transport
CH47_3533	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH47_3534	COG0765	amino acid transport
CH47_3535	COG2252	PERMEase
CH47_3538	COG4191	Histidine kinase
CH47_3539	COG0431	NADPH-dependent FMN reductase
CH47_3540	COG0840	transmembrane signaling receptor activity
CH47_3541	COG2011	ABC-type metal ion transport system permease component
CH47_3544	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH47_3545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH47_3546	COG0706	membrane insertase activity
CH47_3548	COG0594	ribonuclease P activity
CH47_3549	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH47_3550	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH47_3551	COG0592	DNA-directed DNA polymerase activity
CH47_3552	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH47_3553	COG0187	DNA topoisomerase II activity
CH47_3554	COG0561	phosphatase activity
CH47_3555	COG2423	ornithine cyclodeaminase activity
CH47_3556	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH47_3559	COG3727	T/G mismatch-specific endonuclease activity
CH47_356	COG0832	Belongs to the urease beta subunit family
CH47_3561	COG0823	Involved in the tonB-independent uptake of proteins
CH47_3562	COG5645	(Lipo)protein
CH47_3566	COG2985	domain, Protein
CH47_3566	COG0569	domain protein
CH47_3567	COG3977	Valine--pyruvate aminotransferase
CH47_3568	COG0366	Alpha amylase catalytic
CH47_3569	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH47_357	COG0804	urea catabolic process
CH47_3572	COG2885	chlorophyll binding
CH47_3575	COG0456	acetyltransferase
CH47_3576	COG2818	Glycosylase
CH47_3577	COG0752	glycyl-tRNA synthetase alpha subunit
CH47_3578	COG0751	glycine-tRNA ligase activity
CH47_358	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH47_3581	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_3581	COG2213	PTS system mannitol-specific
CH47_3582	COG0246	Mannitol dehydrogenase
CH47_3584	COG3722	fumarate hydratase activity
CH47_3585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH47_3589	COG2258	MOSC domain
CH47_359	COG0830	nickel cation binding
CH47_3590	COG0840	transmembrane signaling receptor activity
CH47_3591	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH47_3592	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH47_3593	COG0243	molybdopterin cofactor binding
CH47_3593	COG3383	formate dehydrogenase (NAD+) activity
CH47_3594	COG0243	molybdopterin cofactor binding
CH47_3594	COG3383	formate dehydrogenase (NAD+) activity
CH47_3595	COG0437	4 iron, 4 sulfur cluster binding
CH47_3596	COG2864	formate dehydrogenase
CH47_3597	COG3058	Necessary for formate dehydrogenase activity
CH47_3598	COG1921	L-seryl-tRNASec selenium transferase activity
CH47_3599	COG3276	selenocysteine insertion sequence binding
CH47_36	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH47_360	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH47_3601	COG3550	peptidyl-serine autophosphorylation
CH47_3604	COG3274	enterobacterial common antigen metabolic process
CH47_3606	COG3121	Chaperone
CH47_3607	COG1070	Carbohydrate kinase
CH47_3608	COG2115	Belongs to the xylose isomerase family
CH47_3609	COG4213	ABC transporter substrate-binding protein
CH47_361	COG0829	nickel cation binding
CH47_3611	COG4214	carbohydrate transport
CH47_3612	COG1609	Transcriptional regulator
CH47_3612	COG2207	Transcriptional regulator
CH47_3614	COG0582	viral genome integration into host DNA
CH47_3618	COG3177	Filamentation induced by cAMP protein fic
CH47_362	COG4413	Urea transporter
CH47_3624	COG1609	Transcriptional regulator
CH47_3625	COG1940	carbohydrate kinase activity
CH47_3626	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH47_3627	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH47_3628	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH47_3629	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH47_363	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH47_3632	COG2723	6-phospho-beta-galactosidase activity
CH47_3633	COG1482	cell wall glycoprotein biosynthetic process
CH47_3634	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH47_3635	COG2986	histidine ammonia-lyase
CH47_3638	COG1764	response to oxidative stress
CH47_3639	COG2194	sulfuric ester hydrolase activity
CH47_3640	COG2197	response regulator
CH47_3641	COG3851	Histidine kinase
CH47_3642	COG2271	Major facilitator Superfamily
CH47_3644	COG3210	domain, Protein
CH47_3645	COG2831	hemolysin activation secretion protein
CH47_3646	COG3210	domain, Protein
CH47_3647	COG0747	negative chemotaxis
CH47_3648	COG0601	transmembrane transport
CH47_3649	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH47_365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH47_3650	COG0444	Belongs to the ABC transporter superfamily
CH47_3651	COG4608	Belongs to the ABC transporter superfamily
CH47_3652	COG2194	sulfuric ester hydrolase activity
CH47_3657	COG1192	Involved in chromosome partitioning
CH47_3658	COG1215	transferase activity, transferring glycosyl groups
CH47_3659	COG1215	transferase activity, transferring glycosyl groups
CH47_366	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CH47_3660	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH47_3661	COG3118	belongs to the thioredoxin family
CH47_3661	COG0457	Tetratricopeptide repeat
CH47_3662	COG2199	diguanylate cyclase activity
CH47_3662	COG2200	EAL domain
CH47_3663	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH47_3666	COG1301	dicarboxylic acid transport
CH47_3667	COG0612	Peptidase, M16
CH47_3668	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH47_3669	COG1942	4-Oxalocrotonate Tautomerase
CH47_3670	COG2200	EAL domain
CH47_3671	COG2982	Protein involved in outer membrane biogenesis
CH47_3672	COG2134	cdp-diacylglycerol pyrophosphatase
CH47_3673	COG1295	ribonuclease BN
CH47_3675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH47_3676	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH47_3678	COG0742	ribosomal rna small subunit methyltransferase
CH47_3679	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CH47_368	COG0667	Aldo Keto reductase
CH47_3681	COG0589	response to stress
CH47_3683	COG0306	phosphate transporter
CH47_3684	COG2081	HI0933 family
CH47_3685	COG1301	dicarboxylic acid transport
CH47_3688	COG3799	methylaspartate ammonia-lyase activity
CH47_3689	COG4865	methylaspartate mutase activity
CH47_369	COG2133	pyrroloquinoline quinone binding
CH47_3691	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH47_3693	COG1648	precorrin-2 dehydrogenase activity
CH47_3693	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH47_3694	COG0583	DNA-binding transcription factor activity
CH47_3695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH47_3695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH47_3697	COG0561	phosphatase activity
CH47_3698	COG0583	DNA-binding transcription factor activity
CH47_3699	COG2814	Major facilitator Superfamily
CH47_370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH47_3702	COG3718	enzyme involved in inositol metabolism
CH47_3704	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH47_3706	COG0673	inositol 2-dehydrogenase activity
CH47_3707	COG1082	Xylose isomerase domain protein TIM barrel
CH47_3708	COG1247	-acetyltransferase
CH47_3709	COG1741	Belongs to the pirin family
CH47_371	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH47_3710	COG1609	Transcriptional regulator
CH47_3711	COG2610	gluconate transmembrane transporter activity
CH47_3712	COG3265	gluconokinase activity
CH47_3713	COG2095	MarC family integral membrane protein
CH47_3714	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH47_3717	COG3275	phosphorelay sensor kinase activity
CH47_3719	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH47_372	COG2723	6-phospho-beta-galactosidase activity
CH47_3720	COG1523	belongs to the glycosyl hydrolase 13 family
CH47_3722	COG0297	glycogen (starch) synthase activity
CH47_3723	COG0058	SHG alpha-glucan phosphorylase activity
CH47_3724	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH47_3727	COG0745	RESPONSE REGULATOR receiver
CH47_3728	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH47_373	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH47_3731	COG2183	response to ionizing radiation
CH47_3732	COG1918	ferrous iron import across plasma membrane
CH47_3733	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CH47_3736	COG0596	Alpha beta hydrolase
CH47_3738	COG0316	Belongs to the HesB IscA family
CH47_3738	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH47_3739	COG1640	4-alpha-glucanotransferase
CH47_374	COG1917	Cupin 2, conserved barrel domain protein
CH47_374	COG2169	Transcriptional regulator
CH47_3740	COG0058	SHG alpha-glucan phosphorylase activity
CH47_3741	COG2909	trisaccharide binding
CH47_3743	COG0705	Rhomboid family
CH47_3744	COG1349	DNA-binding transcription factor activity
CH47_3745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH47_3747	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH47_3748	COG1011	Hydrolase
CH47_375	COG3394	polysaccharide catabolic process
CH47_3750	COG0494	nUDIX hydrolase
CH47_3751	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH47_3756	COG4796	Type ii and iii secretion system protein
CH47_3757	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH47_376	COG0659	secondary active sulfate transmembrane transporter activity
CH47_3761	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH47_3763	COG0180	Tryptophanyl-tRNA synthetase
CH47_3764	COG1648	precorrin-2 dehydrogenase activity
CH47_3764	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH47_3766	COG2146	nitrite reductase [NAD(P)H] activity
CH47_3767	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH47_3768	COG0402	S-adenosylhomocysteine deaminase activity
CH47_3769	COG0738	Major facilitator superfamily
CH47_377	COG0582	viral genome integration into host DNA
CH47_3771	COG1486	melibiose metabolic process
CH47_3772	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH47_3773	COG0433	COG0433 Predicted ATPase
CH47_3776	COG1289	transmembrane transporter activity
CH47_3778	COG1765	OsmC-like protein
CH47_3779	COG3954	Phosphoribulokinase
CH47_3780	COG3089	Belongs to the UPF0270 family
CH47_3781	COG0429	hydrolase of the alpha beta-hydrolase fold
CH47_3784	COG4521	taurine ABC transporter
CH47_3786	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH47_3787	COG2175	clavaminate synthase activity
CH47_3789	COG1216	Glycosyl transferase, family 2
CH47_3790	COG0488	(ABC) transporter
CH47_3791	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH47_3793	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH47_3794	COG1047	Peptidyl-prolyl cis-trans
CH47_3795	COG2900	Belongs to the SlyX family
CH47_3796	COG0545	Peptidyl-prolyl cis-trans isomerase
CH47_3797	COG2964	Protein conserved in bacteria
CH47_3798	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH47_3799	COG2923	Belongs to the DsrF TusC family
CH47_3800	COG2168	tRNA wobble position uridine thiolation
CH47_3801	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH47_3802	COG0049	tRNA binding
CH47_3804	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH47_3808	COG0051	transcription antitermination factor activity, RNA binding
CH47_3809	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH47_3810	COG0088	Forms part of the polypeptide exit tunnel
CH47_3811	COG0089	rRNA binding
CH47_3812	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH47_3813	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH47_3814	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH47_3815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH47_3816	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH47_3817	COG0255	Belongs to the universal ribosomal protein uL29 family
CH47_3818	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH47_3819	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH47_3820	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH47_3821	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CH47_3822	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH47_3823	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CH47_3824	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH47_3825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH47_3826	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH47_3827	COG1841	ribosomal large subunit assembly
CH47_3828	COG0200	Binds to the 23S rRNA
CH47_3829	COG0201	protein transport
CH47_3830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH47_3831	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH47_3832	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH47_3833	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH47_3834	COG0202	RNA polymerase activity
CH47_3835	COG0203	ribosomal protein L17
CH47_3837	COG0789	Transcriptional regulator
CH47_3838	COG3036	rescue of stalled ribosome
CH47_3839	COG1970	mechanosensitive ion channel activity
CH47_3840	COG0569	domain protein
CH47_3841	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH47_3841	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH47_3842	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH47_3843	COG0242	peptide deformylase activity
CH47_3844	COG0758	DNA mediated transformation
CH47_3846	COG0551	DNA topoisomerase type I activity
CH47_3847	COG0009	L-threonylcarbamoyladenylate synthase
CH47_3848	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH47_3849	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH47_3858	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH47_3859	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH47_3861	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH47_3862	COG1414	Transcriptional regulator
CH47_3863	COG0646	methionine synthase
CH47_3863	COG1410	methionine synthase
CH47_3865	COG0527	aspartate kinase activity
CH47_3866	COG0166	Belongs to the GPI family
CH47_3867	COG3223	Belongs to the PsiE family
CH47_3868	COG3833	ABC-type maltose transport systems, permease component
CH47_3869	COG1175	transmembrane transport
CH47_3870	COG2182	Extracellular solute-binding protein
CH47_3872	COG4580	involved in the transport of maltose and maltodextrins
CH47_3875	COG3161	chorismate lyase activity
CH47_3876	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CH47_3877	COG2937	Belongs to the GPAT DAPAT family
CH47_3878	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH47_3879	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH47_3880	COG3237	CsbD-like
CH47_3881	COG0735	belongs to the Fur family
CH47_3887	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH47_3888	COG5532	Uncharacterized conserved protein (DUF2303)
CH47_3897	COG1802	Transcriptional regulator
CH47_3897	COG4626	Terminase
CH47_3901	COG1403	HNH endonuclease
CH47_3903	COG1280	lysine exporter protein (LysE YggA)
CH47_3908	COG3772	lysozyme
CH47_3911	COG3646	Phage regulatory protein
CH47_3929	COG4386	tail sheath protein
CH47_393	COG0582	viral genome integration into host DNA
CH47_3941	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CH47_3944	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH47_3948	COG0305	Participates in initiation and elongation during chromosome replication
CH47_3949	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH47_3950	COG1448	Aminotransferase
CH47_3951	COG2315	Protein conserved in bacteria
CH47_3952	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH47_3954	COG3550	peptidyl-serine autophosphorylation
CH47_3955	COG3620	sequence-specific DNA binding
CH47_3957	COG2252	PERMEase
CH47_3958	COG0025	NhaP-type Na H and K H
CH47_3959	COG0583	DNA-binding transcription factor activity
CH47_3960	COG1380	Effector of murein hydrolase LrgA
CH47_3962	COG1126	abc transporter atp-binding protein
CH47_3963	COG0765	amino acid transport
CH47_3964	COG4597	amino acid ABC transporter
CH47_3965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_3967	COG1560	Kdo2-lipid A biosynthetic process
CH47_3971	COG1278	Cold shock
CH47_3972	COG1278	Cold shock
CH47_3973	COG3133	Outer membrane lipoprotein
CH47_3974	COG3706	GGDEF domain
CH47_3974	COG0745	RESPONSE REGULATOR receiver
CH47_3975	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH47_3976	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH47_3977	COG2264	protein methyltransferase activity
CH47_3978	COG4145	pantothenate transmembrane transporter activity
CH47_3979	COG3924	membrane
CH47_3980	COG0439	Biotin carboxylase
CH47_3981	COG0511	ligase activity, forming carbon-carbon bonds
CH47_3982	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH47_3983	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH47_3985	COG0604	alcohol dehydrogenase
CH47_3986	COG2200	EAL domain
CH47_3986	COG2199	diguanylate cyclase activity
CH47_3988	COG1077	Cell shape determining protein MreB Mrl
CH47_3989	COG1792	Involved in formation and maintenance of cell shape
CH47_3990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH47_3992	COG1530	ribonuclease E activity
CH47_3993	COG3164	Protein of unknown function
CH47_3994	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH47_3995	COG0312	modulator of DNA gyrase
CH47_3996	COG0583	DNA-binding transcription factor activity
CH47_3998	COG1566	PFAM secretion protein HlyD family protein
CH47_3999	COG1289	transmembrane transporter activity
CH47_4	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH47_4002	COG2732	(Barnase) inhibitor
CH47_4003	COG3028	Belongs to the UPF0307 family
CH47_4004	COG0312	modulator of DNA gyrase
CH47_4005	COG3783	Cytochrome b(562)
CH47_4006	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH47_4012	COG3964	amidohydrolase
CH47_4015	COG2706	6-phosphogluconolactonase activity
CH47_4016	COG3711	transcriptional antiterminator
CH47_4016	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_4017	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH47_4019	COG1263	PTS System
CH47_4019	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_4020	COG0366	Alpha amylase catalytic
CH47_4027	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH47_4028	COG0540	Belongs to the ATCase OTCase family
CH47_4034	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_4035	COG1660	Displays ATPase and GTPase activities
CH47_4036	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_4038	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH47_4039	COG1137	ATPase activity
CH47_4040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH47_4041	COG3117	lipopolysaccharide transmembrane transporter activity
CH47_4042	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH47_4043	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH47_4043	COG0517	IMP dehydrogenase activity
CH47_4044	COG0530	calcium, potassium:sodium antiporter activity
CH47_4045	COG1127	ABC transporter
CH47_4046	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH47_4047	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH47_4048	COG2854	intermembrane phospholipid transfer
CH47_4049	COG3113	response to antibiotic
CH47_4050	COG5007	Belongs to the BolA IbaG family
CH47_4051	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH47_4052	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH47_4053	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH47_4054	COG3105	Protein conserved in bacteria
CH47_4055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH47_4056	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH47_4057	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH47_4058	COG0625	glutathione transferase activity
CH47_4059	COG2969	positive regulation of protein catabolic process
CH47_4061	COG0493	'glutamate synthase
CH47_4062	COG0067	glutamate synthase
CH47_4062	COG0070	glutamate synthase
CH47_4062	COG0069	glutamate synthase activity
CH47_4063	COG1242	4 iron, 4 sulfur cluster binding
CH47_4064	COG2198	Histidine kinase
CH47_4064	COG0784	Response regulator, receiver
CH47_4064	COG5002	protein histidine kinase activity
CH47_4065	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH47_4066	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH47_4067	COG2823	Periplasmic or secreted lipoprotein
CH47_4068	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH47_4069	COG0792	nuclease activity
CH47_4071	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH47_4075	COG0667	Aldo Keto reductase
CH47_4076	COG1064	alcohol dehydrogenase
CH47_4077	COG1741	Belongs to the pirin family
CH47_4078	COG0583	DNA-binding transcription factor activity
CH47_4079	COG0435	Glutathione S-transferase
CH47_4080	COG2259	Doxx family
CH47_4082	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH47_4083	COG4575	ribosome binding
CH47_4086	COG0586	Pfam SNARE associated Golgi protein
CH47_409	COG0582	viral genome integration into host DNA
CH47_4090	COG2271	Major facilitator Superfamily
CH47_4091	COG1904	glucuronate isomerase
CH47_4092	COG0246	Mannitol dehydrogenase
CH47_4093	COG2721	sulfolactate sulfo-lyase activity
CH47_4095	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH47_4096	COG0861	Integral membrane protein TerC family
CH47_4097	COG0673	inositol 2-dehydrogenase activity
CH47_4098	COG1451	nucleotide metabolic process
CH47_410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH47_4100	COG2813	Specifically methylates the guanine in position
CH47_4101	COG1902	pentaerythritol trinitrate reductase activity
CH47_4101	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH47_4103	COG3247	response to pH
CH47_4104	COG2814	Major facilitator Superfamily
CH47_4106	COG0076	glutamate decarboxylase activity
CH47_4107	COG0531	amino acid
CH47_4108	COG2066	Belongs to the glutaminase family
CH47_4109	COG1263	PTS System
CH47_4109	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_411	COG2867	negative regulation of translational initiation
CH47_4110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH47_4112	COG1472	Belongs to the glycosyl hydrolase 3 family
CH47_4114	COG3876	Protein conserved in bacteria
CH47_4116	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH47_4117	COG0358	DNA primase activity
CH47_4119	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH47_4120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH47_4121	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH47_4122	COG1968	undecaprenyl-diphosphatase activity
CH47_4123	COG0617	tRNA 3'-terminal CCA addition
CH47_4124	COG4991	sh3 domain protein
CH47_4125	COG3025	triphosphatase activity
CH47_4126	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH47_4127	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH47_4127	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH47_4128	COG0531	amino acid
CH47_413	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH47_4130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH47_4131	COG3384	dioxygenase
CH47_4132	COG0754	glutathionylspermidine amidase activity
CH47_4133	COG5463	Belongs to the UPF0441 family
CH47_4134	COG1538	Outer membrane efflux protein
CH47_4135	COG0494	nUDIX hydrolase
CH47_4136	COG3151	Protein conserved in bacteria
CH47_4139	COG3150	esterase
CH47_414	COG0497	DNA recombination
CH47_4140	COG0187	DNA topoisomerase II activity
CH47_4142	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH47_4143	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH47_4144	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH47_4145	COG0204	Acyl-transferase
CH47_4146	COG2132	Multicopper oxidase
CH47_4148	COG0656	L-ascorbic acid biosynthetic process
CH47_4149	COG1979	alcohol dehydrogenase
CH47_415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH47_4150	COG2207	Transcriptional regulator
CH47_4151	COG0586	Pfam SNARE associated Golgi protein
CH47_4153	COG0811	peptide transport
CH47_4154	COG0848	biopolymer transport protein
CH47_416	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH47_4164	COG4964	Belongs to the GSP D family
CH47_417	COG1943	Transposase
CH47_4170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH47_4171	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_4178	COG1120	ATPase activity
CH47_4179	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH47_418	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH47_4180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH47_4181	COG4592	Periplasmic binding protein
CH47_4182	COG2271	Major facilitator Superfamily
CH47_4183	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_4184	COG0840	transmembrane signaling receptor activity
CH47_4187	COG3133	Outer membrane lipoprotein
CH47_419	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH47_4191	COG2207	Transcriptional regulator
CH47_4193	COG4792	protein secretion
CH47_4194	COG4791	protein targeting
CH47_4195	COG4794	Type iii secretion
CH47_4196	COG4790	Type iii secretion
CH47_4197	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH47_4214	COG4886	Leucine-rich repeat (LRR) protein
CH47_4214	COG4886	Leucine-rich repeat (LRR) protein
CH47_4215	COG3328	transposase activity
CH47_422	COG0513	Belongs to the DEAD box helicase family
CH47_4222	COG2801	Transposase and inactivated derivatives
CH47_4225	COG2963	transposase activity
CH47_4228	COG1943	Transposase
CH47_423	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH47_4230	COG3328	transposase activity
CH47_424	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH47_4244	COG3328	transposase activity
CH47_4245	COG2801	Transposase and inactivated derivatives
CH47_4250	COG1192	Involved in chromosome partitioning
CH47_4251	COG1475	DNA binding
CH47_4254	COG3609	addiction module antidote protein, CC2985 family
CH47_426	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH47_428	COG3086	response to oxidative stress
CH47_43	COG2165	general secretion pathway protein
CH47_430	COG0481	GTPase activity
CH47_431	COG0681	Belongs to the peptidase S26 family
CH47_432	COG0571	ribonuclease III activity
CH47_433	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH47_434	COG1381	Involved in DNA repair and RecF pathway recombination
CH47_435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH47_436	COG0736	holo-[acyl-carrier-protein] synthase activity
CH47_437	COG2610	gluconate transmembrane transporter activity
CH47_438	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH47_439	COG1737	Transcriptional regulator
CH47_441	COG3423	Transcriptional regulator
CH47_443	COG0560	Phosphoserine phosphatase
CH47_445	COG0590	tRNA wobble adenosine to inosine editing
CH47_446	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH47_45	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH47_450	COG2205	protein histidine kinase activity
CH47_451	COG3170	Tfp pilus assembly protein FimV
CH47_452	COG2204	response regulator
CH47_453	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH47_453	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH47_454	COG0347	Belongs to the P(II) protein family
CH47_457	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CH47_458	COG3457	Alanine racemase
CH47_460	COG2188	Transcriptional regulator
CH47_461	COG1017	nitric oxide dioxygenase activity
CH47_461	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH47_462	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH47_463	COG3711	transcriptional antiterminator
CH47_464	COG2814	Major facilitator Superfamily
CH47_465	COG3683	transport system, periplasmic component
CH47_466	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH47_469	COG0483	inositol monophosphate 1-phosphatase activity
CH47_470	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH47_471	COG1959	2 iron, 2 sulfur cluster binding
CH47_473	COG0822	iron-sulfur transferase activity
CH47_474	COG0316	Belongs to the HesB IscA family
CH47_475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH47_476	COG0443	Heat shock 70 kDa protein
CH47_477	COG0633	Ferredoxin
CH47_478	COG2975	iron-sulfur cluster assembly
CH47_481	COG2373	Large extracellular alpha-helical protein
CH47_482	COG4953	penicillin-binding protein 1C
CH47_484	COG0105	UTP biosynthetic process
CH47_485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH47_487	COG1426	Protein conserved in bacteria
CH47_488	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CH47_489	COG0124	histidyl-tRNA synthetase
CH47_490	COG2976	Protein conserved in bacteria
CH47_491	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH47_492	COG1160	GTP binding
CH47_494	COG1645	bacterial-type flagellum-dependent swarming motility
CH47_495	COG1570	exodeoxyribonuclease VII activity
CH47_496	COG0517	IMP dehydrogenase activity
CH47_496	COG0516	GMP reductase activity
CH47_497	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH47_497	COG0519	Catalyzes the synthesis of GMP from XMP
CH47_5	COG1773	rubredoxin
CH47_504	COG0351	phosphomethylpyrimidine kinase
CH47_509	COG1349	DNA-binding transcription factor activity
CH47_510	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_511	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_514	COG3730	PTS system glucitol sorbitol-specific
CH47_516	COG1597	lipid kinase activity
CH47_520	COG3422	double-strand break repair
CH47_521	COG0745	RESPONSE REGULATOR receiver
CH47_522	COG2205	protein histidine kinase activity
CH47_523	COG0477	Major facilitator Superfamily
CH47_524	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH47_526	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_528	COG3539	Fimbrial protein
CH47_530	COG3121	Chaperone
CH47_532	COG0443	Heat shock 70 kDa protein
CH47_533	COG5001	Diguanylate cyclase
CH47_533	COG5002	protein histidine kinase activity
CH47_533	COG3447	MASE1 domain protein
CH47_534	COG2239	Acts as a magnesium transporter
CH47_536	COG0248	Ppx GppA phosphatase
CH47_537	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH47_538	COG2801	Transposase and inactivated derivatives
CH47_539	COG2963	transposase activity
CH47_54	COG0745	RESPONSE REGULATOR receiver
CH47_541	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH47_542	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH47_543	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH47_544	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH47_545	COG2233	PERMEase
CH47_546	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH47_547	COG1393	Belongs to the ArsC family
CH47_548	COG4783	chaperone-mediated protein folding
CH47_549	COG0628	permease
CH47_55	COG2197	response regulator
CH47_550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH47_551	COG2716	regulation of RNA biosynthetic process
CH47_552	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH47_553	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH47_554	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH47_555	COG2321	neutral zinc metallopeptidase
CH47_556	COG2707	UPF0756 membrane protein
CH47_557	COG1444	tRNA N-acetyltransferase activity
CH47_558	COG0400	carboxylic ester hydrolase activity
CH47_560	COG1876	peptidase activity
CH47_561	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH47_562	COG1393	Belongs to the ArsC family
CH47_566	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH47_568	COG2197	response regulator
CH47_570	COG3062	negative regulation of establishment of protein localization
CH47_571	COG0243	molybdopterin cofactor binding
CH47_572	COG3043	anaerobic respiration
CH47_573	COG3005	denitrification pathway
CH47_576	COG0494	nUDIX hydrolase
CH47_578	COG2197	response regulator
CH47_580	COG1671	Belongs to the UPF0178 family
CH47_581	COG0408	coproporphyrinogen oxidase activity
CH47_582	COG0456	acetyltransferase
CH47_583	COG3111	PFAM Bacterial OB fold (BOF) protein
CH47_585	COG2837	iron assimilation
CH47_586	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH47_589	COG2731	YhcH YjgK YiaL family protein
CH47_590	COG1737	Transcriptional regulator
CH47_592	COG4150	thiosulfate binding
CH47_593	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH47_594	COG4208	sulfate ABC transporter
CH47_598	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_599	COG0745	RESPONSE REGULATOR receiver
CH47_6	COG0375	protein maturation
CH47_600	COG2205	protein histidine kinase activity
CH47_601	COG2190	(PTS) system
CH47_602	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH47_603	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_604	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CH47_607	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH47_608	COG3530	Putative quorum-sensing-regulated virulence factor
CH47_614	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH47_619	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH47_620	COG1914	H( )-stimulated, divalent metal cation uptake system
CH47_622	COG0667	Aldo Keto reductase
CH47_624	COG3961	Belongs to the TPP enzyme family
CH47_626	COG0837	glucose binding
CH47_627	COG2223	nitrite transmembrane transporter activity
CH47_628	COG3279	Response regulator of the LytR AlgR family
CH47_629	COG3275	phosphorelay sensor kinase activity
CH47_632	COG0436	Aminotransferase
CH47_633	COG3038	cytochrome b561
CH47_634	COG1598	PFAM Uncharacterised protein family UPF0150
CH47_640	COG1280	lysine exporter protein (LysE YggA)
CH47_644	COG2951	lytic endotransglycosylase activity
CH47_645	COG0531	amino acid
CH47_650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH47_651	COG1127	ABC transporter
CH47_655	COG2755	lipolytic protein G-D-S-L family
CH47_655	COG0657	acetylesterase activity
CH47_656	COG3038	cytochrome b561
CH47_657	COG2353	YceI-like domain
CH47_658	COG1609	Transcriptional regulator
CH47_659	COG1263	PTS System
CH47_659	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_660	COG2723	6-phospho-beta-galactosidase activity
CH47_662	COG1695	Transcriptional regulator
CH47_663	COG2824	Alkylphosphonate utilization operon protein PhnA
CH47_664	COG0582	viral genome integration into host DNA
CH47_675	COG0582	viral genome integration into host DNA
CH47_678	COG2116	formate transmembrane transporter activity
CH47_680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH47_681	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH47_682	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH47_683	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH47_684	COG1138	Cytochrome C-type biogenesis protein
CH47_685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH47_687	COG3088	subunit of a heme lyase
CH47_687	COG4235	cytochrome complex assembly
CH47_69	COG4789	Type iii secretion
CH47_692	COG3691	Protein conserved in bacteria
CH47_693	COG0183	Belongs to the thiolase family
CH47_694	COG1024	Enoyl-CoA hydratase
CH47_694	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH47_695	COG2062	phosphohistidine phosphatase, SixA
CH47_696	COG2840	Smr protein MutS2
CH47_698	COG2890	protein-(glutamine-N5) methyltransferase activity
CH47_699	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH47_7	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH47_700	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH47_701	COG0730	response to heat
CH47_702	COG3101	peptidyl-lysine hydroxylation
CH47_704	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH47_704	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH47_705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH47_706	COG3706	GGDEF domain
CH47_707	COG1794	racemase activity, acting on amino acids and derivatives
CH47_709	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH47_71	COG1157	protein secretion by the type III secretion system
CH47_710	COG2723	6-phospho-beta-galactosidase activity
CH47_711	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH47_713	COG1609	Transcriptional regulator
CH47_715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH47_719	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH47_720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH47_721	COG0697	spore germination
CH47_722	COG0697	spore germination
CH47_724	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH47_726	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH47_728	COG0586	Pfam SNARE associated Golgi protein
CH47_729	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CH47_730	COG0285	dihydrofolate synthase activity
CH47_731	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH47_732	COG1286	toxin biosynthetic process
CH47_733	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH47_734	COG0163	prenyltransferase activity
CH47_735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_736	COG4215	(ABC) transporter
CH47_737	COG4160	amino acid transport
CH47_738	COG4598	ABC transporter
CH47_740	COG1090	epimerase
CH47_744	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH47_745	COG1943	Transposase
CH47_747	COG3037	sugar-specific permease SgaT UlaA
CH47_749	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH47_750	COG1609	Transcriptional regulator
CH47_751	COG1943	Transposase
CH47_752	COG0857	belongs to the CobB CobQ family
CH47_752	COG0280	phosphate acetyltransferase
CH47_754	COG3092	negative regulation of chromosome organization
CH47_755	COG3013	Belongs to the UPF0304 family
CH47_756	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH47_758	COG0490	domain, Protein
CH47_758	COG0471	metal ion transport
CH47_759	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH47_760	COG0436	Aminotransferase
CH47_761	COG0583	DNA-binding transcription factor activity
CH47_762	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_763	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_764	COG0649	NAD binding
CH47_764	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_765	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CH47_767	COG1034	ATP synthesis coupled electron transport
CH47_768	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH47_769	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_770	COG0839	Belongs to the complex I subunit 6 family
CH47_771	COG0713	ATP synthesis coupled electron transport
CH47_772	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH47_773	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH47_774	COG1007	ATP synthesis coupled electron transport
CH47_780	COG3265	gluconokinase activity
CH47_781	COG1028	Short-chain dehydrogenase reductase Sdr
CH47_782	COG1609	Transcriptional regulator
CH47_783	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH47_785	COG4702	Belongs to the UPF0303 family
CH47_786	COG0129	dihydroxy-acid dehydratase activity
CH47_790	COG4575	ribosome binding
CH47_793	COG1169	isochorismate synthase
CH47_794	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH47_795	COG0596	Alpha beta hydrolase
CH47_796	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH47_797	COG1441	menaquinone biosynthetic process
CH47_8	COG0298	carbon dioxide binding
CH47_801	COG0814	amino acid
CH47_806	COG4574	serine-type endopeptidase inhibitor activity
CH47_807	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH47_809	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH47_810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH47_812	COG0784	Response regulator, receiver
CH47_812	COG2205	protein histidine kinase activity
CH47_813	COG2197	response regulator
CH47_814	COG2198	Histidine kinase
CH47_814	COG0642	Histidine kinase
CH47_815	COG2223	nitrite transmembrane transporter activity
CH47_817	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH47_820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH47_831	COG3328	transposase activity
CH47_832	COG1737	Transcriptional regulator
CH47_833	COG1263	PTS System
CH47_833	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH47_833	COG2190	(PTS) system
CH47_834	COG2723	6-phospho-beta-galactosidase activity
CH47_838	COG3082	Protein of unknown function (DUF1414)
CH47_839	COG3081	Nucleoid-associated protein
CH47_840	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CH47_841	COG1061	Type III restriction enzyme res subunit
CH47_842	COG1187	pseudouridine synthase activity
CH47_843	COG2814	Major facilitator Superfamily
CH47_845	COG4172	Belongs to the ABC transporter superfamily
CH47_846	COG4239	(ABC) transporter, permease
CH47_847	COG4174	ABC transporter (Permease)
CH47_848	COG4166	transmembrane transport
CH47_851	COG0791	NLP P60 protein
CH47_852	COG0671	phosphoesterase, PA-phosphatase related
CH47_853	COG0523	cobalamin synthesis protein
CH47_855	COG2186	Transcriptional regulator
CH47_856	COG0246	Mannitol dehydrogenase
CH47_857	COG1312	Catalyzes the dehydration of D-mannonate
CH47_858	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH47_861	COG0243	molybdopterin cofactor binding
CH47_862	COG3005	denitrification pathway
CH47_865	COG1105	Belongs to the carbohydrate kinase PfkB family
CH47_866	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH47_866	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH47_866	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH47_867	COG3710	Transcriptional regulator
CH47_872	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH47_873	COG2855	membrane
CH47_875	COG0583	DNA-binding transcription factor activity
CH47_876	COG0833	amino acid
CH47_877	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH47_879	COG4771	TonB-dependent receptor
CH47_88	COG1289	transmembrane transporter activity
CH47_880	COG0625	glutathione transferase activity
CH47_886	COG2011	ABC-type metal ion transport system permease component
CH47_887	COG0626	cystathionine gamma-synthase activity
CH47_889	COG1686	Belongs to the peptidase S11 family
CH47_890	COG1760	l-serine dehydratase
CH47_891	COG0814	amino acid
CH47_892	COG1349	DNA-binding transcription factor activity
CH47_893	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH47_894	COG0671	phosphoesterase, PA-phosphatase related
CH47_9	COG0409	Hydrogenase expression formation protein
CH47_90	COG1982	Orn Lys Arg decarboxylase major
CH47_909	COG4695	Portal protein
CH47_91	COG0531	amino acid
CH47_933	COG0569	domain protein
CH47_933	COG2985	domain, Protein
CH47_936	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH47_939	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH47_940	COG3842	ATPase activity
CH47_941	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH47_942	COG1177	transmembrane transport
CH47_944	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH47_945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_947	COG4160	amino acid transport
CH47_948	COG4215	(ABC) transporter
CH47_949	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH47_950	COG1126	abc transporter atp-binding protein
CH47_952	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH47_953	COG0702	epimerase
CH47_954	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH47_956	COG0028	Belongs to the TPP enzyme family
CH47_957	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH47_958	COG1151	hydroxylamine reductase activity
CH47_959	COG2431	L-lysine efflux transmembrane transporter activity
CH47_960	COG2990	Protein conserved in bacteria
CH47_961	COG3593	DNA synthesis involved in DNA repair
CH47_962	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH47_964	COG1278	Cold shock
CH47_965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH47_966	COG0542	response to heat
CH47_967	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH47_968	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CH47_969	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH47_971	COG0492	ferredoxin-NADP+ reductase activity
CH47_973	COG1522	sequence-specific DNA binding
CH47_974	COG1674	ftsk spoiiie
CH47_974	COG3107	peptidoglycan biosynthetic process
CH47_976	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH47_977	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH47_978	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH47_979	COG2814	Major facilitator Superfamily
CH47_980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH47_981	COG1882	Formate acetyltransferase
CH47_982	COG2116	formate transmembrane transporter activity
CH47_983	COG1944	ATP diphosphatase activity
CH47_984	COG0252	asparaginase activity
CH47_985	COG2323	membrane
CH47_986	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH47_987	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH47_988	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH47_989	COG0539	negative regulation of cytoplasmic translation
CH47_990	COG0776	regulation of translation
CH47_991	COG2333	competence protein COMEC
CH47_991	COG0658	competence protein
CH47_993	COG1663	tetraacyldisaccharide 4'-kinase activity
CH47_994	COG5383	Protein conserved in bacteria
CH47_995	COG1278	Cold shock
CH47_996	COG1278	Cold shock
CH47_997	COG2835	tetraacyldisaccharide 4'-kinase activity
CH47_998	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CH47_999	COG3173	Aminoglycoside phosphotransferase