locus-tag class description BED35_00120 ENOG4105TNG K13735 adhesin invasin BED35_00125 ENOG4105TNG K13735 adhesin invasin BED35_00265 ENOG4105CKT filamentous hemagglutinin BED35_00270 ENOG4105D5K Hemolysin activator protein BED35_00410 ENOG410607W Transposase BED35_00490 ENOG4105D5G Transposase BED35_00575 ENOG4105D13 transposase BED35_00595 ENOG4106CQM replication BED35_00600 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) BED35_00630 ENOG4105CAU Arsenical resistance protein, ArsH BED35_00635 ENOG4105KBH arsR family transcriptional regulator BED35_00665 ENOG4105DWP Membrane BED35_00720 ENOG4105EZN Cobyrinic acid ac-diamide synthase BED35_00725 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB BED35_00935 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BED35_00940 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BED35_00945 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BED35_00950 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED35_00955 ENOG410667J hydrolase BED35_00965 ENOG4105C7B Threonine dehydratase BED35_00970 ENOG4105D99 atp gtp-binding protein BED35_00975 ENOG4105R2A (LipO)protein BED35_00990 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_01000 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BED35_01005 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BED35_01015 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) BED35_01020 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BED35_01025 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BED35_01030 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BED35_01035 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BED35_01040 ENOG41063M6 Cell Division Protein BED35_01045 ENOG4105ETE Transcriptional regulator (LacI family BED35_01050 ENOG4105C25 Primosomal protein n' BED35_01055 ENOG4105VFB Binds the 23S rRNA (By similarity) BED35_01060 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BED35_01065 ENOG4105C28 cystathionine BED35_01070 ENOG4105CFH Aspartokinase BED35_01075 ENOG4105SYT Methylenetetrahydrofolate reductase BED35_01080 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BED35_01090 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BED35_01095 ENOG4105CAS nag kinase BED35_01100 ENOG4105CH7 arginosuccinase BED35_01135 ENOG4107QZV Type I secretion membrane fusion protein BED35_01155 ENOG4105EHV domain protein BED35_01160 ENOG4105C5Q Transcriptional regulator BED35_01165 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BED35_01170 ENOG4105EJ2 Transcriptional regulator BED35_01175 ENOG4108Y73 Membrane BED35_01180 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) BED35_01190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BED35_01230 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator BED35_01235 ENOG4105C2J ABC transporter BED35_01240 ENOG4107R9N ABC transporter BED35_01245 ENOG41062B0 ABC transporter, permease BED35_01250 ENOG4105CVI Transcriptional regulator BED35_01255 ENOG4108WFC UPF0438 protein yifE BED35_01260 ENOG4105C0P Mg chelatase subunit ChlI BED35_01270 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit BED35_01275 ENOG4105CM2 brancheD-chain amino acid aminotransferase BED35_01280 ENOG4105C01 Dihydroxy-acid dehydratase BED35_01285 ENOG4105C7B Threonine dehydratase BED35_01300 ENOG4105EMY transcriptional regulator BED35_01305 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BED35_01320 ENOG41060S4 immunity protein BED35_01330 ENOG4108VEV chaperone BED35_01350 ENOG4105GQR Chaperone BED35_01365 ENOG41060NJ transcriptional regulator BED35_01380 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures BED35_01390 ENOG4105D5G Transposase BED35_01400 ENOG4105CKT filamentous hemagglutinin BED35_01430 ENOG4105BZU Histidine kinase BED35_01435 ENOG4108KX4 response regulator BED35_01440 ENOG4105DIJ Phosphoethanolamine transferase BED35_01445 ENOG4108ZHJ Organic hydroperoxide resistance protein BED35_01450 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_01455 ENOG4105DEF Extracellular solute-binding protein, family 5 BED35_01460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BED35_01465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED35_01470 ENOG4105C3U ABC transporter BED35_01475 ENOG4108JQ7 (ABC) transporter BED35_01480 ENOG4105D1V cellulose synthase operon protein YhjU BED35_01485 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT BED35_01490 ENOG4105U74 cellulose biosynthesis protein BcsE BED35_01500 ENOG4105UTS cellulose synthase operon protein YhjQ BED35_01505 ENOG4107QZ7 Cellulose synthase catalytic subunit BED35_01510 ENOG4107EEX Cellulose synthase regulator protein BED35_01515 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) BED35_01520 ENOG4105EJG cellulose synthase BED35_01530 ENOG4105BZU Histidine kinase BED35_01535 ENOG4108PU9 oligogalacturonate-specific porin BED35_01550 ENOG4105CK2 sodium dicarboxylate symporter BED35_01555 ENOG4105CS0 peptidase BED35_01560 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BED35_01565 ENOG4105VSH 4-oxalocrotonate tautomerase BED35_01570 ENOG4105CMB EAL domain-containing protein BED35_01580 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) BED35_01585 ENOG4107H3J ribonuclease BED35_01595 ENOG4105DC8 reductase BED35_01600 ENOG4105D6S protein involved in catabolism of external DNA BED35_01605 ENOG4105DGW oligopeptidase A BED35_01610 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) BED35_01625 ENOG4108M6U Universal stress protein A BED35_01630 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_01635 ENOG4108V6B universal stress protein B BED35_01640 ENOG4105CJ3 phosphate transporter BED35_01645 ENOG4105CBX hi0933 family BED35_01685 ENOG4108BUD transposase BED35_01690 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BED35_01710 ENOG4105CK2 sodium dicarboxylate symporter BED35_01730 ENOG4105DJI Methylaspartate mutase, E subunit BED35_01745 ENOG4105JZC GHMP kinase BED35_01750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED35_01755 ENOG41090KR LysR family transcriptional Regulator BED35_01760 ENOG4107GFK fumarate BED35_01770 ENOG4108HCJ Hydrolase BED35_01780 ENOG4105CR8 Transcriptional regulator BED35_01785 ENOG4105EQ0 Major Facilitator superfamily BED35_01790 ENOG4105C26 Dehydrogenase BED35_01795 ENOG4105DH8 myo-inositol catabolism BED35_01805 ENOG4105D7K pfkb domain protein BED35_01815 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BED35_01820 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BED35_01825 ENOG4105WCN acetyltransferase BED35_01830 ENOG4105C2I pirin domain protein BED35_01835 ENOG4105DIQ Transcriptional regulator BED35_01840 ENOG4105C6Z Gluconate BED35_01845 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BED35_01850 ENOG41076UM multiple antibiotic resistance (MarC)-related protein BED35_01855 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BED35_01860 ENOG4105C7K acetolactate synthase BED35_01875 ENOG4108HRK Histidine kinase BED35_01880 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BED35_01885 ENOG4108IUM Glycogen debranching enzyme BED35_01895 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BED35_01900 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BED35_01905 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BED35_01915 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_01920 ENOG4105E98 transcriptional regulator DeoR family BED35_01925 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) BED35_01940 ENOG41061ZR Transcriptional regulator BED35_01945 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BED35_01950 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BED35_01955 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BED35_01960 ENOG4105MJ2 Competence protein BED35_01965 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BED35_01970 ENOG4105RID UPF0379 protein yhcN BED35_01975 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_01980 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) BED35_01985 ENOG4105CE1 Ferrous iron transport protein b BED35_01990 ENOG4105XFK Ferrous iron transport protein A BED35_01995 ENOG4105BZM domain protein BED35_02020 ENOG4108RRZ Transcription elongation factor GreB BED35_02025 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BED35_02030 ENOG4105E0F Histidine kinase BED35_02035 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BED35_02045 ENOG4105VEJ Heat shock protein BED35_02050 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 BED35_02055 ENOG4105DQY intracellular growth attenuator BED35_02060 ENOG4107RK2 ADP-ribose diphosphatase NudE BED35_02065 ENOG4108JQC penicillin-binding protein 1A BED35_02090 ENOG4105E4G Type IV pilus BED35_02095 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BED35_02115 ENOG4105DJV ribulose-phosphate 3-epimerase BED35_02125 ENOG4105C31 Tryptophanyl-tRNA synthetase BED35_02130 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED35_02140 ENOG4105WZK nitrite reductase NADPH small subunit BED35_02145 ENOG4107QZF nitrite reductase NADPH large subunit BED35_02150 ENOG4105DZC cytosine deaminase BED35_02155 ENOG4106DTQ Protein TsgA homolog BED35_02160 ENOG41060NJ transcriptional regulator BED35_02165 ENOG4105F8D glycoside hydrolase family 4 BED35_02170 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BED35_02175 ENOG4105D7A ATP-binding protein BED35_02185 ENOG4105C8Y Acetylornithine aminotransferase BED35_02200 ENOG4108UKZ OsmC family BED35_02205 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BED35_02210 ENOG4105YP7 UPF0270 protein BED35_02215 ENOG4105DNZ Alpha Beta Hydrolase BED35_02225 ENOG4105JAB phenazine biosynthesis protein, phzf family BED35_02230 ENOG4106FTQ Taurine ABC transporter, periplasmic BED35_02240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BED35_02245 ENOG4105E2B Taurine dioxygenase BED35_02255 ENOG4105K64 Glycosyl transferase, family 2 BED35_02260 ENOG4105C5H ABC transporter BED35_02265 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BED35_02275 ENOG4105VKU nucleicacid-binding protein BED35_02280 ENOG4108YZY peptidylprolyl cis-trans isomerase BED35_02290 ENOG4108V1T peptidylprolyl cis-trans isomerase BED35_02295 ENOG4105WWK YheO domain protein BED35_02300 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BED35_02305 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BED35_02310 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BED35_02320 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BED35_02350 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BED35_02355 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BED35_02360 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BED35_02365 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BED35_02370 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BED35_02375 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BED35_02380 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BED35_02385 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BED35_02390 ENOG41083MP 50s ribosomal protein l29 BED35_02395 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BED35_02405 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BED35_02410 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BED35_02415 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BED35_02425 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BED35_02430 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BED35_02435 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BED35_02440 ENOG4105VPB 50S ribosomal protein L30 BED35_02445 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BED35_02450 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BED35_02455 ENOG41067V7 50S ribosomal protein L36 BED35_02465 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BED35_02470 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BED35_02475 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BED35_02480 ENOG4108ZT0 50S ribosomal protein l17 BED35_02485 ENOG4105VTS DnaJ-like, subfamily C BED35_02490 ENOG4105W1Y Transcriptional regulator BED35_02495 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system BED35_02505 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BED35_02510 ENOG4105C1A potassium transporter peripheral membrane BED35_02515 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BED35_02520 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BED35_02525 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BED35_02530 ENOG4105C79 DNA protecting protein DprA BED35_02540 ENOG4108WI1 Dna topoisomerase BED35_02545 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BED35_02550 ENOG4105E2X shikimate dehydrogenase BED35_02555 ENOG4108Z0R Transferase BED35_02585 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_02590 ENOG4105CVG Homoserine O-transsuccinylase BED35_02595 ENOG4107QP3 malate synthase g BED35_02600 ENOG4108I9X Isocitrate lyase BED35_02605 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) BED35_02610 ENOG41069M3 Transcriptional regulator BED35_02615 ENOG4105C3R Methionine synthase BED35_02635 ENOG4105CFH Aspartokinase BED35_02640 ENOG4107QP8 phosphohexose isomerase BED35_02650 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_02655 ENOG4105EG2 ABC transporter, permease BED35_02665 ENOG4107FKK extracellular solute-binding protein family 1 BED35_02675 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BED35_02680 ENOG4107W52 maltose operon periplasmic protein BED35_02690 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BED35_02695 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BED35_02700 ENOG4105E55 glycerol-3-phosphate acyltransferase BED35_02705 ENOG41080IJ Diacylglycerol kinase BED35_02710 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BED35_02715 ENOG4105VDW Csbd family BED35_02720 ENOG4105MYN Zinc uptake regulation protein BED35_02725 ENOG4105EXC Acyl-transferase BED35_02730 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BED35_02735 ENOG4105P4Z Phage shock protein G BED35_02745 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BED35_02750 ENOG4105CDU Replicative dna helicase BED35_02760 ENOG4105CGF Aromatic amino acid aminotransferase BED35_02765 ENOG4105MSB protein, conserved in bacteria BED35_02770 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BED35_02780 ENOG4105CAF HipA N-terminal domain protein BED35_02795 ENOG4105C7N Xanthine uracil vitamin C permease BED35_02800 ENOG4105EEQ Na H antiporter BED35_02805 ENOG4105CMU LysR family (Transcriptional regulator BED35_02820 ENOG4105CDA abc transporter atp-binding protein BED35_02825 ENOG4105DRP amino acid AbC transporter BED35_02830 ENOG4105EZ7 amino acid ABC transporter BED35_02845 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_02850 ENOG4105D1S lipid A biosynthesis BED35_02855 ENOG4107QPK )-transporter BED35_02860 ENOG4105VEQ Cold shock protein BED35_02865 ENOG4105VEQ Cold shock protein BED35_02870 ENOG4108XTF Outer Membrane Lipoprotein BED35_02880 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BED35_02885 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BED35_02890 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BED35_02895 ENOG4108IA2 Sodium pantothenate symporter BED35_02900 ENOG4105RG0 Membrane BED35_02905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BED35_02910 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BED35_02915 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BED35_02920 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) BED35_02930 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BED35_02935 ENOG41062P1 Diguanylate cyclase phosphodiesterase BED35_02940 ENOG4105DFF Rod shape-determining protein mreb BED35_02945 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BED35_02950 ENOG4105VQ7 Rod shape-determining protein MreD BED35_02960 ENOG4105C03 ribonuclease BED35_02965 ENOG4105QD6 exported protein BED35_02975 ENOG4105D1U peptidase U62 modulator of DNA gyrase BED35_03030 ENOG4105CR8 Transcriptional regulator BED35_03040 ENOG4105Y49 secretion protein, HlyD family BED35_03045 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) BED35_03060 ENOG4105UNR (Barnase) inhibitor BED35_03065 ENOG4105N42 UPF0307 protein BED35_03070 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED35_03100 ENOG4105DFE Dna adenine methylase BED35_03245 ENOG4105CMS peptidase U62, modulator of DNA gyrase BED35_03250 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_03255 ENOG4108XVM Cytochrome b(562) BED35_03260 ENOG4105NXH GreA GreB family elongation factor BED35_03290 ENOG41069H0 dihydroorotase EC 3.5.2.3 BED35_03310 ENOG4105EMD TRANSCRIPTIONal BED35_03315 ENOG41084S7 Plasmid maintenance system antidote protein BED35_03330 ENOG4105D4X repressor BED35_03340 ENOG4105CG3 alpha amylase, catalytic region BED35_03365 ENOG4105KME endoribonuclease L-psp BED35_03370 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) BED35_03375 ENOG4105CXT aspartate transcarbamylase BED35_03380 ENOG41080Z8 PHOSPHOCARRIER protein BED35_03385 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BED35_03390 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BED35_03395 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BED35_03400 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED35_03405 ENOG4108IUZ ABC transporter BED35_03410 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BED35_03415 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) BED35_03420 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BED35_03425 ENOG4105C2X Arabinose 5-phosphate isomerase BED35_03435 ENOG4105DHJ ABC, transporter BED35_03440 ENOG4105CY3 ABC transporter, permease BED35_03445 ENOG4107PE3 Mammalian cell entry related domain protein BED35_03450 ENOG4105E3I toluene tolerance BED35_03455 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane BED35_03460 ENOG4105VFK BolA family BED35_03465 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BED35_03470 ENOG4105C0H protease BED35_03475 ENOG4105C0H protease BED35_03480 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III BED35_03485 ENOG4105D6Z AFG1 family ATPase BED35_03490 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BED35_03495 ENOG4108UJD 30S ribosomal protein S9 BED35_03500 ENOG4107MKT Stringent starvation protein a BED35_03505 ENOG4105KB2 stringent starvation protein b BED35_03520 ENOG4105BZ8 glutamate synthase BED35_03525 ENOG4105CBC glutamate synthase BED35_03530 ENOG4105N5T Radical SAM Protein BED35_03535 ENOG4105BZU Histidine kinase BED35_03540 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BED35_03545 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BED35_03550 ENOG4105W4M Transport-associated protein BED35_03555 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BED35_03560 ENOG41082RQ UPF0102 protein BED35_03570 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BED35_03590 ENOG4108C33 Resolvase BED35_03625 ENOG4108VEV chaperone BED35_03630 ENOG4105CW0 outer membrane usher protein BED35_03640 ENOG4105EQ2 LysR family Transcriptional regulator BED35_03645 ENOG4107SET aldo keto reductase BED35_03650 ENOG4105DQ4 alcohol dehydrogenase BED35_03655 ENOG4108CNN domain protein BED35_03660 ENOG4105CWB LysR family transcriptional Regulator BED35_03665 ENOG4105CHF Glutathione S-transferase BED35_03670 ENOG4108VBZ doxx family BED35_03675 ENOG4105YJD BED35_03680 ENOG41090KG Inner membrane protein YqjE BED35_03685 ENOG4105NE1 Conserved Protein BED35_03700 ENOG4106W5V Membrane BED35_03715 ENOG4105DPW Major facilitator superfamily MFS_1 BED35_03720 ENOG4105D2H Uronic isomerase BED35_03725 ENOG4107QZW Altronate oxidoreductase BED35_03730 ENOG4105CTX dehydratase BED35_03735 ENOG4105P66 Membrane BED35_03740 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BED35_03745 ENOG4105DU1 integral membrane protein, terc BED35_03755 ENOG4105EE0 oxidoreductase BED35_03760 ENOG4108VKG metal-dependent hydrolase BED35_03780 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BED35_03785 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_03790 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BED35_03795 ENOG4108594 Permease of the drug metabolite transporter BED35_03800 ENOG4108YK4 Acid-resistance membrane protein BED35_03810 ENOG4105CVK Glutamate decarboxylase BED35_03815 ENOG4105E5D amino acid BED35_03820 ENOG4105CSV Glutaminase BED35_03830 ENOG4105D5G Transposase BED35_03835 ENOG4105C5Y PTS System BED35_03840 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BED35_03845 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) BED35_03850 ENOG4105D17 glycoside hydrolase, family 3 domain protein BED35_03860 ENOG4105EHZ conserved protein UCP016719 BED35_03870 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_03875 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED35_03880 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BED35_03885 ENOG4105VCC 30S ribosomal protein S21 BED35_03890 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BED35_03895 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BED35_03900 ENOG4107ZVW dihydroneopterin aldolase BED35_03905 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BED35_03910 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BED35_03915 ENOG4106MWK domain protein BED35_03920 ENOG4105I7R Adenylate cyclase BED35_03925 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BED35_03930 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BED35_03935 ENOG4105DVH amino acid BED35_03940 ENOG4105W0Z cytoplasmic protein BED35_03945 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BED35_03950 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BED35_03955 ENOG4106032 Glutathionylspermidine synthase BED35_03960 ENOG4105F1G UPF0441 protein BED35_03970 ENOG4105DFG type I secretion outer membrane protein BED35_03975 ENOG41087AY ADP-Ribose pyrophosphatase BED35_03980 ENOG4108SX3 cytoplasmic protein BED35_03985 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BED35_03990 ENOG4105IPS esterase BED35_03995 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED35_04000 ENOG4105JQN Transcriptional regulator BED35_04005 ENOG4105VRH Antibiotic biosynthesis monooxygenase BED35_04010 ENOG4105NF4 modulator of drug activity BED35_04015 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED35_04020 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BED35_04025 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) BED35_04035 ENOG4105CV8 reductase BED35_04040 ENOG4108I6A alcohol dehydrogenase BED35_04045 ENOG4105CF7 AraC family transcriptional regulator BED35_04050 ENOG4108K81 inner membrane protein YghB BED35_04055 ENOG4105C28 cystathionine BED35_04060 ENOG4105CWK Biopolymer transport protein, ExbB BED35_04065 ENOG4108ZZF transport protein (ExbD) BED35_04140 ENOG4105CF1 Alkylated DNA repair protein BED35_04145 ENOG4108IJF Heavy metal efflux pump, CzcA BED35_04155 ENOG4108RAV Conserved protein BED35_04195 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED35_04230 ENOG4105E0A ABC, transporter BED35_04235 ENOG4105TVJ transport system, permease BED35_04240 ENOG4105DQ5 transport system permease protein BED35_04245 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein BED35_04255 ENOG4105EXW epimerase dehydratase BED35_04260 ENOG4105C8Q Methyl-accepting chemotaxis BED35_04275 ENOG4105D00 flagellar biosynthetic protein flhB BED35_04280 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BED35_04285 ENOG4105VS8 Flagellar biosynthetic protein fliq BED35_04290 ENOG4105CN7 Flagellar biosynthetic protein FliP BED35_04295 ENOG4105DD5 Flagellar motor switch protein BED35_04305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BED35_04310 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BED35_04330 ENOG4108JIR Flagellum-specific ATP synthase BED35_04355 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BED35_04360 ENOG4108ZC9 flagellar basal-body rod protein flgc BED35_04365 ENOG4105W00 Flagellar hook capping protein BED35_04370 ENOG4105BZE flagellar hook protein, FlgE BED35_04375 ENOG4108KPB Flagellar basal-body rod protein FlgF BED35_04380 ENOG4105CGA flagellar basal-body rod protein FlgG BED35_04390 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BED35_04425 ENOG4105I03 Flagellin BED35_04435 ENOG4105MQ3 flagellar protein FliS BED35_04460 ENOG4107RD7 Flagellar Motor Protein, MotA BED35_04470 ENOG4108XTF Outer Membrane Lipoprotein BED35_04475 ENOG4105E3S small subunit BED35_04480 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED35_04485 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit BED35_04490 ENOG4105DPX Hydrogenase, large subunit BED35_04495 ENOG4108USZ hydrogenase BED35_04500 ENOG4108WGS hydrogenase 2-specific chaperone BED35_04505 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BED35_04510 ENOG4107RSS Hydrogenase accessory protein HypB BED35_04515 ENOG41082MF Hydrogenase assembly chaperone hypC hupF BED35_04520 ENOG4105CQS hydrogenase expression formation protein HypD BED35_04525 ENOG4105C45 hydrogenase expression formation protein (HypE) BED35_04530 ENOG4105C8H hydrogenase maturation protein Hypf BED35_04535 ENOG4107R3N Filamentation induced by cAMP protein fic BED35_04540 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BED35_04560 ENOG4105ENT Efflux transporter rnd family, mfp subunit BED35_04575 ENOG4105CSH Transporter BED35_04590 ENOG4105EAM Na Pi-cotransporter BED35_04600 ENOG4105ETE Transcriptional regulator (LacI family BED35_04605 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_04620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED35_04650 ENOG4105CM4 permease protein BED35_04660 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BED35_04680 ENOG4105J12 Multidrug resistance protein mdtN BED35_04685 ENOG4108MI0 Resistance protein BED35_04695 ENOG4105CXN decarboxylase BED35_04700 ENOG4105D5Q Arginine ornithine antiporter BED35_04755 ENOG4105CXN decarboxylase BED35_04765 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BED35_04770 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BED35_04775 ENOG4105CEN a g-specific adenine glycosylase BED35_04780 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BED35_04785 ENOG41090ED Protein with unknown function (DUF469) BED35_04790 ENOG4105CSV Glutaminase BED35_04795 ENOG4105K33 Periplasmic Protein BED35_04800 ENOG4105CSA Coproporphyrinogen iii oxidase BED35_04805 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BED35_04810 ENOG4105VZ9 UPF0235 protein BED35_04815 ENOG4108VIA integral membrane protein BED35_04820 ENOG4105II7 pyrroline-5-carboxylate reductase BED35_04825 ENOG4105DFA alanine racemase domain protein BED35_04830 ENOG4105CZX twitching motility protein BED35_04840 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) BED35_04845 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BED35_04850 ENOG4108UJU UPF0301 protein BED35_04855 ENOG4105D7Z glutathione synthase BED35_04860 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BED35_04865 ENOG4105RWS endonuclease I BED35_04870 ENOG4105GPY SprT protein BED35_04875 ENOG41080HT Transcriptional regulator, arsr family BED35_04880 ENOG4105D5G Transposase BED35_04895 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BED35_04900 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BED35_04910 ENOG4108K0D peptidase, M48 BED35_04915 ENOG4105CV1 Transketolase (EC 2.2.1.1) BED35_04920 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BED35_04925 ENOG4105BZA Phosphoglycerate kinase BED35_04930 ENOG4105D2N Aldolase BED35_04940 ENOG4105D64 Mechanosensitive ion channel BED35_04945 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_04950 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BED35_04955 ENOG4105MPN Membrane BED35_04960 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BED35_04965 ENOG4105E66 phosphoriboisomerase A BED35_04970 ENOG4108JQ1 Dehydrogenase BED35_05005 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BED35_05025 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BED35_05030 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BED35_05035 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BED35_05040 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BED35_05055 ENOG4108MXK alkaline phosphatase isozyme conversion BED35_05060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED35_05065 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BED35_05070 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BED35_05075 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BED35_05080 ENOG4105N0Z inner membrane protein ygbE BED35_05085 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BED35_05095 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BED35_05100 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BED35_05105 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BED35_05110 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BED35_05115 ENOG4108K5P (LipO)protein BED35_05120 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED35_05125 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BED35_05150 ENOG4106PG1 outer membrane usher protein BED35_05155 ENOG4108FZ9 Chaperone BED35_05165 ENOG4105UGQ Fimbrial BED35_05170 ENOG4105H8W Fimbrial protein BED35_05195 ENOG4108JJA ABC, transporter BED35_05200 ENOG4105DJY efflux transporter, rnd family, mfp subunit BED35_05210 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BED35_05215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED35_05230 ENOG4105CHR reductase BED35_05235 ENOG4105CIH Imidazole acetol-phosphate transaminase BED35_05240 ENOG4105CA0 peroxidase BED35_05250 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BED35_05255 ENOG4105YVS arsR family transcriptional regulator BED35_05260 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein BED35_05265 ENOG4105F3R pts system mannose fructose sorbose family iid BED35_05270 ENOG4105ETZ PTS System BED35_05280 ENOG4108XCU pts system BED35_05285 ENOG4105DKT Transcriptional regulator BED35_05310 ENOG4108IV0 ABC, transporter BED35_05315 ENOG4108IUZ ABC transporter BED35_05320 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BED35_05325 ENOG4105C32 Amino acid ABC transporter (Permease) BED35_05335 ENOG4107GFK fumarate BED35_05340 ENOG4107QY8 reductase BED35_05345 ENOG4105QAX Iron-sulfur BED35_05350 ENOG4107KGK dmso reductase anchor subunit BED35_05355 ENOG4108NEM leader-binding protein dmsD BED35_05360 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_05365 ENOG4108ISG Major Facilitator BED35_05375 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BED35_05380 ENOG4105Y3E Modulates RecA activity (By similarity) BED35_05385 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BED35_05390 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BED35_05410 ENOG4107VXZ Hydrolase BED35_05420 ENOG4105D9M gamma-glutamylcysteine synthetase BED35_05425 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BED35_05430 ENOG4108JU6 CBS domain protein BED35_05435 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_05445 ENOG4106KVJ cytochrome C assembly protein BED35_05450 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BED35_05455 ENOG4105K5M 30s ribosomal protein S16 BED35_05460 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BED35_05465 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BED35_05470 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BED35_05480 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BED35_05485 ENOG4108NEV two component transcriptional regulator, LytTR family BED35_05490 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BED35_05495 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BED35_05500 ENOG4105CQC Prephenate dehydratase BED35_05505 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_05510 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BED35_05515 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BED35_05520 ENOG4105C34 Pseudouridine synthase BED35_05525 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BED35_05535 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BED35_05540 ENOG4105D5G Transposase BED35_05545 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_05575 ENOG4105T42 (LipO)protein BED35_05580 ENOG4105JIM Phosphatidylserine synthase BED35_05585 ENOG4105CD5 CoA-binding domain protein BED35_05590 ENOG4106IUH DTW domain containing protein BED35_05595 ENOG4105K63 Thioredoxin BED35_05600 ENOG4105EIB trna rrna methyltransferase BED35_05605 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED35_05610 ENOG4105CW7 secretion protein, HlyD family BED35_05615 ENOG4105ETP RND efflux system, outer membrane lipoprotein BED35_05620 ENOG4105NTK Transcriptional repressor Mpra BED35_05625 ENOG4105ZED uncharacterized protein ygaH BED35_05630 ENOG4108UMN azlc family BED35_05635 ENOG4105EQ0 Major Facilitator superfamily BED35_05670 ENOG4105E5Q amino acid AbC transporter BED35_05675 ENOG4105E5Q amino acid AbC transporter BED35_05700 ENOG4105CHM Aminotransferase BED35_05705 ENOG4107R08 Integrase BED35_05760 ENOG41076J9 exonuclease VIII BED35_05840 ENOG4106CVF DNA replication protein BED35_05875 ENOG4105RWQ Protein of unknown function (DUF1364) BED35_05910 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED35_06075 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BED35_06080 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) BED35_06085 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BED35_06090 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BED35_06095 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BED35_06115 ENOG4107QPN acyl-Coa dehydrogenase BED35_06125 ENOG4105E7A Glutamine amidotransferase BED35_06130 ENOG4105F7V ErfK ybiS ycfS ynhG family protein BED35_06135 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED35_06140 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED35_06145 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED35_06150 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED35_06160 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BED35_06165 ENOG4105CJ2 (LipO)protein BED35_06180 ENOG4105CPF Cell wall formation (By similarity) BED35_06185 ENOG4105WWK YheO domain protein BED35_06200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BED35_06205 ENOG4105CIN aminoacyl-histidine dipeptidase BED35_06210 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BED35_06215 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_06220 ENOG4105V1F Fermentation respiration switch protein BED35_06225 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) BED35_06230 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BED35_06235 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BED35_06240 ENOG4105FDP GntR family transcriptional regulator BED35_06245 ENOG4105CI1 PTS System BED35_06250 ENOG4105F8D glycoside hydrolase family 4 BED35_06260 ENOG4105E2V Glycosyltransferase 36 BED35_06275 ENOG4105F2W methyltransferase BED35_06300 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BED35_06305 ENOG4105NBK UPF0345 protein BED35_06310 ENOG4105DH7 May be involved in recombination (By similarity) BED35_06315 ENOG4105DKQ ROK family BED35_06320 ENOG4105EYH Exonuclease BED35_06325 ENOG4107RH8 nuclease SbcCD subunit D BED35_06330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BED35_06335 ENOG4105BZU Histidine kinase BED35_06345 ENOG4105CWM branched-chain amino acid transport system II carrier protein BED35_06350 ENOG4105C85 amino acid BED35_06355 ENOG4107R28 alpha amylase, catalytic region BED35_06360 ENOG4105CHR reductase BED35_06370 ENOG41074AV Hok/gef family BED35_06375 ENOG4105D3R alkyl hydroperoxide reductase BED35_06380 ENOG4108ZYK Acyl carrier protein phosphodiesterase BED35_06385 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BED35_06395 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BED35_06400 ENOG4105VIE preprotein translocase, subunit YajC BED35_06405 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BED35_06410 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BED35_06425 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BED35_06430 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BED35_06435 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BED35_06440 ENOG4107YIM Involved in the transcription termination process (By similarity) BED35_06445 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BED35_06450 ENOG4108ZAI phosphatidylglycerophosphatase a BED35_06455 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_06460 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BED35_06465 ENOG4105CTB Polyprenyl synthetase BED35_06475 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BED35_06480 ENOG4107S0N DJ-1 family BED35_06485 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BED35_06490 ENOG4108VPT UPF0234 protein BED35_06495 ENOG4107RDB Major Facilitator BED35_06500 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BED35_06505 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) BED35_06510 ENOG4105CCU oxidase (Subunit III) BED35_06515 ENOG4105BZ9 Cytochrome C oxidase, subunit I BED35_06520 ENOG4105E2S oxidase) subunit II BED35_06525 ENOG4108NFH Sugar hydrolase BED35_06530 ENOG4105EYM Major Facilitator superfamily BED35_06535 ENOG4105IEY (LipO)protein BED35_06540 ENOG4105M85 Bola protein BED35_06550 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BED35_06555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BED35_06560 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BED35_06565 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BED35_06570 ENOG4105K70 DNA-binding protein BED35_06575 ENOG4105EIN peptidylprolyl cis-trans isomerase BED35_06580 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BED35_06585 ENOG4108TGP Thioesterase superfamily protein BED35_06590 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BED35_06595 ENOG4108NFA extracellular solute-binding protein BED35_06600 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) BED35_06610 ENOG4108XM1 transcriptional regulator AsnC family BED35_06615 ENOG4105BZ1 (ABC) transporter BED35_06620 ENOG4105BZ1 (ABC) transporter BED35_06625 ENOG4108YZA Nitrogen regulatory protein pii BED35_06630 ENOG4105BZU Histidine kinase BED35_06635 ENOG4105C29 acyl-CoA thioesterase BED35_06640 ENOG4108MNP Glycoprotein polysaccharide metabolism BED35_06645 ENOG41080UX Methyltransferase BED35_06655 ENOG4105KF5 hemolysin expression-modulating protein BED35_06660 ENOG4108UKR Biofilm formation regulator YbaJ BED35_06670 ENOG4105DIK (ABC) transporter BED35_06675 ENOG4105CC5 ABC transporter BED35_06680 ENOG4105DSE periplasmic solute binding protein BED35_06685 ENOG4105YK5 50S ribosomal protein L36 BED35_06690 ENOG4105NRA 50s ribosomal protein l31 type b BED35_06695 ENOG4106M0N transport system permease protein BED35_06700 ENOG4105MUZ Protein of unknown function DUF2620 BED35_06705 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BED35_06710 ENOG4108626 Racemase BED35_06720 ENOG4105BZS acriflavin resistance protein BED35_06725 ENOG4105C1P efflux transporter, rnd family, mfp subunit BED35_06730 ENOG4108IG5 Transcriptional regulator BED35_06735 ENOG41090EX DsrE family BED35_06745 ENOG4106428 Protein of unknown function (DUF2496) BED35_06755 ENOG4105WD1 Membrane BED35_06760 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BED35_06765 ENOG4107QMP dna polymerase iii subunits gamma and tau BED35_06770 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BED35_06775 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BED35_06780 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BED35_06785 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BED35_06790 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BED35_06795 ENOG4105ER6 polysaccharide biosynthesis protein BED35_06805 ENOG4108SHN Glycosyl transferase, family 2 BED35_06810 ENOG4105CG5 Glycosyl transferase (Group 1 BED35_06815 ENOG4107RJ7 Glycosyl transferase (Group 1 BED35_06820 ENOG4105ESV Glycosyl transferase, family 4 BED35_06835 ENOG4105CMR udp-glucose 4-epimerase BED35_06840 ENOG4107RE1 Inosine-guanosine kinase BED35_06845 ENOG4105CKD glutathione-regulated potassium-efflux system protein BED35_06850 ENOG4105EU0 Major facilitator Superfamily BED35_06865 ENOG4108Z66 YbaK ebsC protein BED35_06870 ENOG4105MBR gumn family BED35_06875 ENOG4105C59 p-type ATPase BED35_06880 ENOG4108Z6Z Transcriptional regulator BED35_06885 ENOG4105G5H Membrane BED35_06890 ENOG4107QX8 SPFH domain, Band 7 family protein BED35_06895 ENOG4107QR8 Thioredoxin BED35_06900 ENOG4105E1F short-chain dehydrogenase reductase BED35_06905 ENOG4108UJV acyl-CoA thioesterase i BED35_06910 ENOG4108I0Y (ABC) transporter BED35_06915 ENOG4105CV6 ABC transporter, permease BED35_06920 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BED35_06925 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BED35_06930 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BED35_06935 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BED35_06940 ENOG4105C8N cysteinyl-tRNA synthetase BED35_06945 ENOG4105WQ3 Rna-binding protein BED35_06950 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BED35_06960 ENOG4108KU3 Integrase BED35_07010 ENOG41076J9 exonuclease VIII BED35_07075 ENOG4106CVF DNA replication protein BED35_07110 ENOG4105RWQ Protein of unknown function (DUF1364) BED35_07160 ENOG4105MPK DNA polymerase III subunit theta BED35_07235 ENOG4105TKZ Tail Sheath BED35_07295 ENOG4105EXC Acyl-transferase BED35_07300 ENOG4108KU3 Integrase BED35_07425 ENOG4105CDU Replicative dna helicase BED35_07475 ENOG4108R1E Serine threonine protein phosphatase 1 BED35_07515 ENOG4105KUS lysozyme BED35_07520 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED35_07680 ENOG4105DFP Integrase BED35_07685 ENOG4105DFP Integrase BED35_07690 ENOG4105DFP Integrase BED35_07705 ENOG4107R3N Filamentation induced by cAMP protein fic BED35_07760 ENOG4105KT5 UmuD protein BED35_07780 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_07790 ENOG4105EZE Cupin 4 family protein BED35_07800 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BED35_07805 ENOG4108JJ7 ABC transporter BED35_07820 ENOG4108R1E Serine threonine protein phosphatase 1 BED35_07840 ENOG4105VEQ Cold shock protein BED35_07845 ENOG4107Z6W Protein CrcB homolog BED35_07850 ENOG4105BZU Histidine kinase BED35_07855 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) BED35_07860 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BED35_07865 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BED35_07870 ENOG4108Z43 UPF0250 protein BED35_07875 ENOG4105DZ1 carboxypeptidase BED35_07880 ENOG4105K6T rare lipoprotein A BED35_07885 ENOG4105CNI cell division protein FtsW BED35_07890 ENOG4105CJN penicillin-binding protein BED35_07900 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BED35_07905 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BED35_07910 ENOG4105DJF DNA polymerase III, delta' subunit BED35_07915 ENOG4108U2H Rare lipoprotein B BED35_07920 ENOG4105C8T Leucyl-tRNA synthetase BED35_07925 ENOG4107PAI alpha helical protein BED35_07930 ENOG4105CDA abc transporter atp-binding protein BED35_07935 ENOG4105DRP amino acid AbC transporter BED35_07940 ENOG4105EAD ABC transporter BED35_07945 ENOG4107RP9 extracellular solute-binding protein, family 3 BED35_07955 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BED35_07960 ENOG4108JU5 Magnesium and cobalt efflux protein BED35_07970 ENOG4105C9A Phoh family BED35_07975 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BED35_07980 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BED35_08015 ENOG4105CAQ asparagine synthetase BED35_08020 ENOG4105D4U had-superfamily hydrolase, subfamily iia BED35_08025 ENOG4105E2R ROK family BED35_08030 ENOG4105CE4 GlcNAc 6-P deacetylase BED35_08035 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BED35_08045 ENOG4105CX6 glutaminyL-tRNA synthetase BED35_08055 ENOG4105GX6 (LipO)protein BED35_08065 ENOG41090R7 Ferric uptake BED35_08070 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BED35_08075 ENOG4105C8Q Methyl-accepting chemotaxis BED35_08080 ENOG4105NNH LexA regulated protein BED35_08085 ENOG4105EV9 Alpha Beta Hydrolase BED35_08095 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BED35_08110 ENOG4105EEX Two component transcriptional regulator (Winged helix family BED35_08115 ENOG4105C08 Histidine kinase BED35_08120 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BED35_08125 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BED35_08130 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BED35_08140 ENOG4105XIQ Protein of unknown function (DUF2517) BED35_08150 ENOG4108RC6 RTX toxin BED35_08160 ENOG4107SEY Conserved Protein BED35_08165 ENOG4105CVP deoxyribo-dipyrimidine photolyase BED35_08170 ENOG4107RF4 Phosphodiesterase BED35_08175 ENOG4107QNR UPF0135 protein BED35_08180 ENOG4105P4J Allophanate hydrolase, subunit 1 BED35_08185 ENOG4107R7A Allophanate hydrolase subunit 2 BED35_08190 ENOG4105E7W lamb ycsf family protein BED35_08205 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BED35_08210 ENOG4105BZN citrate synthase BED35_08215 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BED35_08220 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BED35_08230 ENOG4105E33 succinate dehydrogenase BED35_08235 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BED35_08240 ENOG4105C7S Dehydrogenase BED35_08245 ENOG4105CMV Succinyl-CoA synthetase subunit beta BED35_08250 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BED35_08255 ENOG4105CGH 5'-nucleotidase BED35_08260 ENOG4105C4M (Ubiquinol oxidase) subunit I BED35_08265 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BED35_08275 ENOG4105KJB cyd operon protein YbgE BED35_08280 ENOG4107YD3 Thioesterase BED35_08285 ENOG4105E02 MotA TolQ exbB proton channel BED35_08290 ENOG4105M8F Biopolymer transport protein exbD tolR BED35_08295 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA BED35_08295 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA BED35_08300 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BED35_08305 ENOG4105KCK Peptidoglycan-associated lipoprotein BED35_08310 ENOG4105UFD tol-pal system protein YbgF BED35_08335 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BED35_08340 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BED35_08345 ENOG4105PGM cation diffusion facilitator family transporter BED35_08350 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BED35_08355 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BED35_08380 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BED35_08385 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BED35_08390 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BED35_08395 ENOG4105CMR udp-glucose 4-epimerase BED35_08405 ENOG4105DKW ABC transporter BED35_08410 ENOG4105F4R Transcriptional regulator mode BED35_08415 ENOG410680R Protein of unknown function (DUF2592) BED35_08420 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BED35_08425 ENOG4105E0C molybdate abc transporter BED35_08435 ENOG4108K4B hydrolase BED35_08440 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BED35_08450 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BED35_08455 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BED35_08460 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BED35_08465 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BED35_08475 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BED35_08480 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BED35_08485 ENOG4105CHW UPF0052 protein BED35_08490 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BED35_08495 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BED35_08500 ENOG4105M00 molybdopterin converting factor, subunit 1 BED35_08505 ENOG4108ZAF Molybdopterin BED35_08510 ENOG4105HFZ Membrane BED35_08515 ENOG4107QWP ABC-2 type transporter BED35_08520 ENOG4107QWP ABC-2 type transporter BED35_08525 ENOG4105CJ1 ABC, transporter BED35_08530 ENOG4105D0S secretion protein (HlyD BED35_08535 ENOG4107MVR Transcriptional regulator BED35_08540 ENOG4105C1J atp-dependent rna helicase BED35_08545 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BED35_08555 ENOG4105CJW magnesium transporter BED35_08560 ENOG41061WM D-Alanyl-D-Alanine BED35_08565 ENOG4105CXG d-lactate dehydrogenase BED35_08575 ENOG4105N1F Hnh endonuclease BED35_08585 ENOG4105Y3U Transglycosylase-associated protein BED35_08595 ENOG4105EHI Phosphonate ABC transporter, periplasmic BED35_08610 ENOG4108W15 Protein of unknown function (DUF1456) BED35_08620 ENOG4105C32 Amino acid ABC transporter (Permease) BED35_08625 ENOG4105CNN ABC, transporter BED35_08630 ENOG4105D5T phosphonate abc transporter BED35_08635 ENOG4108IV0 ABC, transporter BED35_08640 ENOG4105KHC sulfurtransferase BED35_08655 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system BED35_08665 ENOG4108IJ8 ABC transporter BED35_08670 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component BED35_08685 ENOG4105HEI LysR family (Transcriptional regulator BED35_08695 ENOG4105FDR Membrane BED35_08710 ENOG4105DVT helicase BED35_08715 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BED35_08720 ENOG4108MTB glycosyl transferase family BED35_08740 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) BED35_08745 ENOG4107SDU Methyl-accepting chemotaxis BED35_08750 ENOG4105CDA abc transporter atp-binding protein BED35_08755 ENOG4105E5Q amino acid AbC transporter BED35_08760 ENOG4107R0W ABC transporter BED35_08765 ENOG4105KSC Transcriptional regulator, TraR DksA family BED35_08770 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BED35_08775 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BED35_08810 ENOG4108T1M outer membrane protein x BED35_08830 ENOG4105C5H ABC transporter BED35_08835 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_08840 ENOG4105D06 uba thif-type nad fad binding protein BED35_08845 ENOG4105CVM Molybdenum cofactor synthesis domain protein BED35_08860 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED35_08890 ENOG4105EGI Transcriptional regulator BED35_08895 ENOG4105CBP Major Facilitator BED35_08900 ENOG4105EUJ GTP cyclohydrolase i BED35_08905 ENOG4105DHF Membrane BED35_08910 ENOG41060NJ transcriptional regulator BED35_08925 ENOG4107SDZ Galactoside transport system permease protein mglC BED35_08930 ENOG4108JUA Transcriptional regulator BED35_08940 ENOG4108RC0 Electron transport protein BED35_08945 ENOG4108MG9 hydrogenase 3 maturation protease BED35_08950 ENOG4105I6X formate hydrogenlyase maturation BED35_08955 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit BED35_08965 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED35_08970 ENOG4108JPZ Monovalent cation H antiporter subunit D BED35_08975 ENOG4107WQX hydrogenase 4 membrane subunit BED35_08980 ENOG4105D65 subunit l BED35_08985 ENOG4107TDF Formate hydrogenlyase subunit 4 BED35_08990 ENOG4108JPZ Monovalent cation H antiporter subunit D BED35_08995 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) BED35_09000 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BED35_09010 ENOG4107GZ4 SanA protein BED35_09015 ENOG4107R1I NAD-dependent malic enzyme BED35_09030 ENOG41067MG lrgb family BED35_09035 ENOG4105VAW lrga family BED35_09040 ENOG4105E5W Transporter BED35_09060 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BED35_09065 ENOG4105D1F ATP-binding protein BED35_09070 ENOG4105DBI uridine monophosphokinase BED35_09080 ENOG4108GAE asmA family BED35_09085 ENOG4105CEE C4-dicarboxylate transporter BED35_09090 ENOG4105EE5 Membrane protein terC BED35_09125 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BED35_09135 ENOG4107RGC Glycosyl transferase, family 2 BED35_09150 ENOG4105D5G Transposase BED35_09175 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BED35_09180 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BED35_09185 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BED35_09190 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BED35_09195 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BED35_09200 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BED35_09205 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BED35_09210 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BED35_09215 ENOG4105CIH Imidazole acetol-phosphate transaminase BED35_09225 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BED35_09230 ENOG4108535 NAD dependent epimerase/dehydratase family BED35_09235 ENOG4105CNN ABC, transporter BED35_09240 ENOG4105C2J ABC transporter BED35_09245 ENOG4107SCQ Iron-containing alcohol dehydrogenase BED35_09255 ENOG4105CUB amino acid BED35_09260 ENOG4105CJB Exodeoxyribonuclease I BED35_09265 ENOG4105E4E Thioester reductase domain-containing protein BED35_09270 ENOG4105DR8 Membrane BED35_09275 ENOG41090HJ UPF0265 protein BED35_09285 ENOG4105CNN ABC, transporter BED35_09290 ENOG4105C2J ABC transporter BED35_09295 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BED35_09300 ENOG4105JZC GHMP kinase BED35_09305 ENOG4107QZB decarboxylase BED35_09310 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED35_09315 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BED35_09320 ENOG4105KTW ethanolamine utilization protein BED35_09325 ENOG4105M3W utilization protein BED35_09335 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BED35_09345 ENOG4108EKI Dehydrogenase BED35_09355 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml BED35_09365 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) BED35_09375 ENOG4105KNY Microcompartments protein BED35_09385 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit BED35_09390 ENOG4108ZFT Dehydratase small subunit BED35_09395 ENOG4105YCI dehydratase medium subunit BED35_09400 ENOG4105DMB glycerol dehydratase BED35_09405 ENOG4105EHR propanediol utilization protein pduB BED35_09410 ENOG4105KNY Microcompartments protein BED35_09415 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BED35_09420 ENOG4107XVH Transcriptional regulator BED35_09425 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BED35_09435 ENOG41081F0 Precorrin-8x methylmutase BED35_09440 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) BED35_09445 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase BED35_09450 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase BED35_09455 ENOG4105CIA precorrin-4 C(11)-methyltransferase BED35_09460 ENOG4108P62 biosynthesis protein (CbiG) BED35_09465 ENOG4105E4R Precorrin-3B C17-methyltransferase BED35_09470 ENOG4105QUC reductase BED35_09475 ENOG4107PPM cobalt chelatase BED35_09480 ENOG4105DVK Precorrin-2 c20-methyltransferase BED35_09485 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) BED35_09495 ENOG4108V4M Cobalt abc transporter BED35_09505 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BED35_09515 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BED35_09520 ENOG4108TGR phosphatase BED35_09525 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BED35_09570 ENOG4105CS6 Rhs element vgr protein BED35_09595 ENOG4105CDH Citrulline--aspartate ligase BED35_09600 ENOG4105UQX Mate efflux family protein BED35_09610 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BED35_09615 ENOG410667J hydrolase BED35_09620 ENOG4105E98 transcriptional regulator DeoR family BED35_09625 ENOG4107S1E Beta-lactamase BED35_09630 ENOG4107R88 Chemotaxis protein (CheV) BED35_09660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED35_09665 ENOG4107RCV ABC transporter, permease BED35_09670 ENOG4105C4Y ABC transporter BED35_09675 ENOG4105CXY transporter BED35_09680 ENOG4105BZU Histidine kinase BED35_09685 ENOG4108KX4 response regulator BED35_09690 ENOG4106YYS transcriptional regulatory protein BED35_09695 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BED35_09710 ENOG4105DUA (citrate (pro-3S)-lyase ligase BED35_09715 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) BED35_09720 ENOG4105CI0 Citrate lyase BED35_09725 ENOG4105CHY citrate lyase, alpha BED35_09730 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BED35_09735 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BED35_09740 ENOG4107QPK )-transporter BED35_09755 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BED35_09765 ENOG4108TSE Transferase BED35_09775 ENOG4105C54 Major Facilitator superfamily BED35_09780 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BED35_09785 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme BED35_09790 ENOG4105D3G Pseudouridine synthase BED35_09805 ENOG4108MQF Chaperone BED35_09835 ENOG4108Q9V regulatoR BED35_09845 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) BED35_09855 ENOG4105CMG Carbohydrate kinase BED35_09880 ENOG4108S1B Periplasmic chaperone protein BED35_09885 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_09890 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BED35_09900 ENOG41061EV selenium-binding protein YdfZ BED35_09915 ENOG4105GSJ Inner membrane protein ylaC BED35_09925 ENOG4105D5G Transposase BED35_09930 ENOG4105CNT hydrolase family 2 BED35_09935 ENOG4105ETE Transcriptional regulator (LacI family BED35_09940 ENOG4105VEQ Cold shock protein BED35_09945 ENOG4105VZF DsrB protein BED35_09950 ENOG4105C8Q Methyl-accepting chemotaxis BED35_09965 ENOG4105KT7 mgtC SapB transporter BED35_09970 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BED35_09975 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BED35_09980 ENOG4108VA4 Universal stress protein BED35_09985 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) BED35_09990 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region BED35_09995 ENOG4107RD7 Flagellar Motor Protein, MotA BED35_10000 ENOG4105ER2 Ompa motb domain protein BED35_10005 ENOG4105CBS Chea signal transduction histidine kinase BED35_10010 ENOG4108V3W Chemotaxis protein, CheW BED35_10015 ENOG4105C8Q Methyl-accepting chemotaxis BED35_10020 ENOG4105C8Q Methyl-accepting chemotaxis BED35_10025 ENOG4105BZU Histidine kinase BED35_10035 ENOG4108VYJ response regulator receiver protein BED35_10040 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) BED35_10045 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin BED35_10050 ENOG4105D00 flagellar biosynthetic protein flhB BED35_10055 ENOG4105D7B Flagellar biosynthesis protein flha BED35_10060 ENOG4105W13 flagellar protein BED35_10070 ENOG4105QVD Flagella synthesis protein FlgN BED35_10075 ENOG4105M9M anti-sigma28 factor FlgM BED35_10080 ENOG4105CKS Flagella basal body P-ring formation protein flgA BED35_10085 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BED35_10090 ENOG4108ZC9 flagellar basal-body rod protein flgc BED35_10095 ENOG4105W00 Flagellar hook capping protein BED35_10100 ENOG4105BZE flagellar hook protein, FlgE BED35_10105 ENOG4108KPB Flagellar basal-body rod protein FlgF BED35_10110 ENOG4105CGA flagellar basal-body rod protein FlgG BED35_10125 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BED35_10130 ENOG4105E1Q flagellar hook-associated protein BED35_10135 ENOG4105DTJ flagellar hook-associated protein BED35_10140 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BED35_10145 ENOG4105VS8 Flagellar biosynthetic protein fliq BED35_10150 ENOG4105CN7 Flagellar biosynthetic protein FliP BED35_10160 ENOG4105DD5 Flagellar motor switch protein BED35_10165 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BED35_10170 ENOG4107ZI8 flagellar basal body-associated protein flil BED35_10175 ENOG4105WF4 Flagellar hook-length control protein BED35_10180 ENOG4105GSA Flagellar export protein flij BED35_10185 ENOG4108JIR Flagellum-specific ATP synthase BED35_10190 ENOG41090PJ Flagellar assembly protein BED35_10195 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BED35_10200 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BED35_10205 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BED35_10210 ENOG4107R08 Integrase BED35_10235 ENOG4105DHT Metal Dependent Phosphohydrolase BED35_10245 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) BED35_10250 ENOG4105MQ3 flagellar protein FliS BED35_10255 ENOG4105DTS flagellar hook-associated BED35_10265 ENOG4105I03 Flagellin BED35_10275 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED35_10280 ENOG4108M9K flagella biosynthesis protein FliZ BED35_10285 ENOG4105K6H D-cysteine desulfhydrase BED35_10290 ENOG4105EAB amino acid AbC transporter BED35_10300 ENOG4105CDA abc transporter atp-binding protein BED35_10315 ENOG4105C26 Dehydrogenase BED35_10320 ENOG4105CK7 Sodium proline symporter BED35_10335 ENOG4105GMB type VI secretion system effector, hcp1 family BED35_10355 ENOG4105CS1 NAD(P)H quinone oxidoreductase BED35_10365 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) BED35_10380 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) BED35_10385 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) BED35_10390 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BED35_10400 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BED35_10410 ENOG4108R86 Transcriptional regulator BED35_10415 ENOG4105C85 amino acid BED35_10425 ENOG4108KU3 Integrase BED35_10455 ENOG4105E5K Alpha-amylase BED35_10465 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BED35_10485 ENOG4105ZTC transcriptional activator, Ogr delta BED35_10490 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_10565 ENOG4105EXG Transcriptional regulator BED35_10585 ENOG4105HRS Antitermination protein BED35_10600 ENOG4105KUS lysozyme BED35_10610 ENOG4108Q2J Inner membrane protein YebE BED35_10620 ENOG41066YJ Beta-lactamase BED35_10625 ENOG4105C3G gtp-binding protein BED35_10635 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BED35_10640 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria BED35_10650 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BED35_10660 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BED35_10665 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BED35_10670 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BED35_10675 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BED35_10680 ENOG4108YY7 Invasion gene expression up-regulator SirB BED35_10685 ENOG41063JG Transcriptional regulator BED35_10690 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BED35_10695 ENOG4105CHH sulfate transporter BED35_10700 ENOG4105BZU Histidine kinase BED35_10725 ENOG4107SSZ Phosphatase BED35_10730 ENOG4107XHZ cytoplasmic chaperone TorD family protein BED35_10735 ENOG4105F3T (LipO)protein BED35_10740 ENOG4105EV4 Multidrug resistance protein mdtH BED35_10755 ENOG4105D9U N-acetyltransferase BED35_10765 ENOG4105EP9 oxidoreductase BED35_10770 ENOG4105CJR Integral membrane protein (MviN BED35_10775 ENOG4105EWV Sodium calcium exchanger membrane region BED35_10785 ENOG4105F27 Major Facilitator BED35_10790 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_10800 ENOG4105BZU Histidine kinase BED35_10805 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BED35_10810 ENOG4105C4M (Ubiquinol oxidase) subunit I BED35_10815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED35_10820 ENOG4105C8Y Acetylornithine aminotransferase BED35_10825 ENOG4105F4X arginine BED35_10835 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) BED35_10840 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) BED35_10845 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_10870 ENOG4105CI2 imidazolone-5-propionate hydrolase BED35_10875 ENOG4105CZE histidine utilization repressor BED35_10880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BED35_10910 ENOG4108K5P (LipO)protein BED35_10915 ENOG4105D2N Aldolase BED35_10920 ENOG4105E70 isomerase BED35_10925 ENOG4108YTN IIa component BED35_10930 ENOG4105F3R pts system mannose fructose sorbose family iid BED35_10940 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB BED35_10945 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of BED35_10950 ENOG4105E98 transcriptional regulator DeoR family BED35_10960 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_10970 ENOG4105FE9 pseudouridine synthase BED35_10975 ENOG4105D6U Sodium Glutamate Symporter BED35_10985 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_10990 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_10995 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BED35_11000 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) BED35_11005 ENOG4105WJG Glutathione BED35_11010 ENOG41081XQ Conserved Protein BED35_11015 ENOG4105D3W isochorismatase BED35_11020 ENOG4105C9M aspartyl-trna synthetase BED35_11025 ENOG4108TIT dATP pyrophosphohydrolase BED35_11030 ENOG4105CDY transcriptional regulatory protein BED35_11035 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BED35_11040 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BED35_11045 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BED35_11050 ENOG4105DUX Transporter BED35_11055 ENOG4105FAV ABC, transporter BED35_11060 ENOG4105FDK ABC transporter BED35_11065 ENOG4105NXV High-affinity zinc uptake system protein BED35_11070 ENOG4105DR5 peptidase BED35_11075 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BED35_11090 ENOG4105CA9 Pyruvate kinase BED35_11095 ENOG4106KNT transcriptional regulator BED35_11100 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BED35_11105 ENOG4108UHU Aldolase BED35_11110 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) BED35_11120 ENOG4105M4H endoribonuclease L-psp BED35_11125 ENOG4105DVT helicase BED35_11130 ENOG41072GX Peptidase M22 Glycoprotease BED35_11140 ENOG4105CEY Amp-dependent synthetase and ligase BED35_11145 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BED35_11150 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BED35_11155 ENOG4107QMS site-determining protein BED35_11160 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BED35_11170 ENOG4105VNG YcgL domain-containing protein BED35_11175 ENOG4105CVE Lytic murein transglycosylase BED35_11180 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BED35_11185 ENOG4108ZZ3 UPF0260 protein BED35_11210 ENOG4105D64 Mechanosensitive ion channel BED35_11215 ENOG4108SHQ Glutathione S-transferase BED35_11235 ENOG4105WT8 Protein of unknown function (DUF1480) BED35_11265 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED35_11275 ENOG4105DY2 Paraquat-inducible protein b BED35_11280 ENOG4105H2K paraquat-inducible protein a BED35_11285 ENOG4108ZGC gaf domain protein BED35_11295 ENOG4105CN1 protease BED35_11300 ENOG4105D0M Protease HtpX homolog BED35_11315 ENOG4105CAZ oligogalacturonide lyase BED35_11325 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BED35_11335 ENOG4107K5X Membrane-bound metal-dependent hydrolase BED35_11345 ENOG4108PU9 oligogalacturonate-specific porin BED35_11350 ENOG4105WEM extracellular solute-binding protein BED35_11355 ENOG4108IJ9 (ABC) transporter BED35_11360 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BED35_11365 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BED35_11370 ENOG41061NF Pectate lyase BED35_11375 ENOG4105CHR reductase BED35_11380 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BED35_11385 ENOG4105M5J Cupin 2, conserved barrel domain protein BED35_11390 ENOG4105D5G Transposase BED35_11395 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BED35_11400 ENOG4107PN8 YfeABCD locus regulator BED35_11405 ENOG4105DEQ transcriptional regulator BED35_11410 ENOG4105CYC Transferase BED35_11415 ENOG4108M7F enoyl-CoA hydratase isomerase BED35_11420 ENOG4105DJT lAO AO transport system ATPase BED35_11430 ENOG4105FGM Fructosamine kinase BED35_11435 ENOG4105CC5 ABC transporter BED35_11440 ENOG4105CC5 ABC transporter BED35_11445 ENOG4105DIK (ABC) transporter BED35_11450 ENOG4105DSE periplasmic solute binding protein BED35_11455 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BED35_11460 ENOG41082NP Multiple antibiotic resistance BED35_11485 ENOG4108UQV Membrane BED35_11490 ENOG41087WU BED35_11495 ENOG4105C22 threonyL-tRNA synthetase BED35_11500 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BED35_11505 ENOG41082NX 50s ribosomal protein l35 BED35_11510 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BED35_11515 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BED35_11525 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BED35_11540 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) BED35_11545 ENOG4108V06 Glutathione peroxidase BED35_11550 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) BED35_11555 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BED35_11560 ENOG4105CKK Glycosyl transferase, family 2 BED35_11565 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BED35_11570 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BED35_11575 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BED35_11580 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BED35_11585 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BED35_11590 ENOG4108QBX (LipO)protein BED35_11615 ENOG4107ENK receptor BED35_11620 ENOG4107F3C Hemin uptake protein BED35_11625 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BED35_11630 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BED35_11635 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BED35_11645 ENOG4105IPI Membrane BED35_11650 ENOG4105CQB FAD linked oxidase domain protein BED35_11655 ENOG4105KA0 thioesterase Superfamily protein BED35_11660 ENOG4108Z4V iron-sulfur cluster assembly BED35_11665 ENOG4105DIW FeS assembly protein SUFB BED35_11670 ENOG4105C3K feS assembly ATPase SufC BED35_11675 ENOG4105JRK feS assembly protein SufD BED35_11685 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BED35_11690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BED35_11695 ENOG4105KMX major outer membrane lipoprotein BED35_11700 ENOG4105CA9 Pyruvate kinase BED35_11720 ENOG4108R6K riboflavin synthase, subunit alpha BED35_11725 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BED35_11730 ENOG4105CZQ inner membrane transport protein YdhC BED35_11735 ENOG4105F52 Transcriptional regulator BED35_11740 ENOG4105ETE Transcriptional regulator (LacI family BED35_11745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BED35_11750 ENOG4105K4H Nlp p60 protein BED35_11755 ENOG4105M2J Glutaredoxin BED35_11760 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BED35_11770 ENOG4108UYE Lactoylglutathione lyase BED35_11780 ENOG4108WUH Transcriptional regulator, TetR family BED35_11785 ENOG4105DIJ Phosphoethanolamine transferase BED35_11790 ENOG4105XZD Fe-S protein BED35_11795 ENOG4107RGM aldo keto reductase BED35_11800 ENOG4105DSW Fusaric acid resistance protein BED35_11815 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) BED35_11820 ENOG4108XTF Outer Membrane Lipoprotein BED35_11825 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BED35_11830 ENOG410642K Lysozyme inhibitor BED35_11835 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BED35_11840 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BED35_11850 ENOG4108K3A Glutathione S-transferase BED35_11855 ENOG4108ZR5 Conserved Protein BED35_11860 ENOG41069YE inner membrane protein yohC BED35_11870 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_11875 ENOG4105DUX Transporter BED35_11880 ENOG4105DUM transcriptional regulator, lysR family BED35_11885 ENOG4105Q4T oxidoreductase BED35_11895 ENOG4108JQ2 peptide transport system atp-binding protein BED35_11900 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BED35_11905 ENOG4108EU3 peptide transport system, permease BED35_11910 ENOG4108I5W peptide transport system, permease protein BED35_11915 ENOG4108HIY periplasmic BED35_11930 ENOG4105E51 psp operon transcriptional activator BED35_11935 ENOG41087YS Phage shock protein A BED35_11940 ENOG4105YYT phage shock protein B BED35_11945 ENOG4105FM1 phage shock protein C BED35_11955 ENOG4105CM6 amino acid regulated cytosolic protein BED35_11960 ENOG4106K28 UPF0283 membrane protein BED35_11980 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BED35_11985 ENOG4107S8C mandelate racemase muconate lactonizing BED35_11990 ENOG4105KXI murein peptide amidase A BED35_11995 ENOG4107QSI ABC, transporter BED35_12000 ENOG4107RX3 Mg2 transporter protein cora family protein BED35_12005 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BED35_12010 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BED35_12025 ENOG4105KT7 mgtC SapB transporter BED35_12035 ENOG4105C5I Dehydrogenase BED35_12040 ENOG4107H52 Dicarboxylate transport BED35_12045 ENOG410689M (LipO)protein BED35_12050 ENOG4105WXT Conserved Protein BED35_12055 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BED35_12060 ENOG4105CQ7 ATP-dependent helicase BED35_12075 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap BED35_12085 ENOG4105CTD carboxy-peptidase BED35_12090 ENOG4105JJR Histidine kinase BED35_12095 ENOG4107EXC regulatoR BED35_12105 ENOG4105D5Q Arginine ornithine antiporter BED35_12110 ENOG4105C5D exported protein BED35_12120 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BED35_12125 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BED35_12130 ENOG4105Q9Y Universal stress protein BED35_12135 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BED35_12140 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BED35_12155 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) BED35_12160 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BED35_12185 ENOG4105PAD Hydrolase BED35_12190 ENOG4105M71 acetolactate synthase 1 regulatory subunit BED35_12195 ENOG4105C7K acetolactate synthase BED35_12205 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BED35_12245 ENOG4106NZI LysR family Transcriptional regulator BED35_12250 ENOG4105D94 Major Facilitator Superfamily BED35_12265 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) BED35_12275 ENOG4105C9Q fumarate hydratase class II BED35_12280 ENOG4105EIP mannose-6-phosphate isomerase BED35_12285 ENOG4106J39 exported protein BED35_12295 ENOG4107P2S Transcriptional regulator BED35_12300 ENOG4105CI1 PTS System BED35_12305 ENOG4105C87 Aminotransferase class I and II BED35_12310 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BED35_12315 ENOG4105DHU Bile acid BED35_12320 ENOG4105D9R oxidoreductase BED35_12340 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator BED35_12350 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BED35_12360 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BED35_12370 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BED35_12385 ENOG4105M9B inner membrane protein ydgK BED35_12390 ENOG4105DGN Electron transport complex BED35_12400 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BED35_12410 ENOG4105UEI Transcriptional Regulator AraC Family BED35_12415 ENOG4105D6A Electron transport complex BED35_12420 ENOG4108UQQ Electron transport complex BED35_12430 ENOG4105CSM endonuclease III BED35_12530 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED35_12595 ENOG4106CVF DNA replication protein BED35_12675 ENOG41076J9 exonuclease VIII BED35_12695 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) BED35_12700 ENOG4105D22 carbon starvation protein BED35_12705 ENOG4105VCD cytoplasmic protein BED35_12710 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BED35_12715 ENOG4105N2W Transcriptional regulator BED35_12725 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BED35_12730 ENOG41061RM osmotically inducible lipoprotein BED35_12735 ENOG4108ZJT translation initiation factor, Sui1 BED35_12740 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BED35_12745 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction BED35_12750 ENOG4105DKK Benzoate BED35_12755 ENOG4108JCI Transcriptional regulator BED35_12765 ENOG4105CFV Tetratricopeptide repeat protein BED35_12770 ENOG4105Q4A inner membrane protein yciS BED35_12775 ENOG4105EYK Phosphatidylglycerophosphatase B BED35_12780 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BED35_12785 ENOG4107QM5 aconitate hydratase BED35_12795 ENOG4107R11 Transcriptional regulator BED35_12800 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BED35_12805 ENOG4105RKX Protein of unknown function (DUF2498) BED35_12810 ENOG4105ERU peptidase BED35_12815 ENOG4105UBK short-chain dehydrogenase reductase BED35_12820 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BED35_12830 ENOG4105FE9 pseudouridine synthase BED35_12835 ENOG4107RTD sua5 ycio yrdc ywlc family protein BED35_12840 ENOG4105DB7 PHP domain protein BED35_12850 ENOG4105DDQ anthranilate synthase BED35_12860 ENOG4105DK0 Indole-3-glycerol phosphate synthase BED35_12865 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BED35_12870 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BED35_12880 ENOG4105EIF outer membrane protein W BED35_12885 ENOG4105PI0 Ferredoxin BED35_12890 ENOG4108S3I UPF0259 membrane protein BED35_12900 ENOG4107835 probably involved in intracellular septation (By similarity) BED35_12905 ENOG4105NAU thioesterase Superfamily protein BED35_12910 ENOG410822N TonB family BED35_12915 ENOG4105K9H YciI-like protein BED35_12930 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BED35_12935 ENOG4108W5H UPF0263 protein BED35_12940 ENOG4108JQ7 (ABC) transporter BED35_12945 ENOG4105C3U ABC transporter BED35_12950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED35_12955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BED35_12960 ENOG4107QSI ABC, transporter BED35_12965 ENOG4107QSI ABC, transporter BED35_12970 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BED35_12975 ENOG4108EKI Dehydrogenase BED35_12980 ENOG4107104 thymidine kinase BED35_12995 ENOG4105C6Y Udp-glucose 6-dehydrogenase BED35_13000 ENOG4105I93 response regulator BED35_13005 ENOG4105D78 K07001 NTE family protein BED35_13015 ENOG4105K5B UPF0225 protein BED35_13020 ENOG4105CIY formyltetrahydrofolate deformylase BED35_13035 ENOG4105SKE transcriptional Regulator LysR family BED35_13040 ENOG4105CGK Exodeoxyribonuclease III BED35_13045 ENOG4105M6F mutator MutT protein BED35_13050 ENOG4105MTM Protein of unknown function (DUF1496) BED35_13055 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BED35_13065 ENOG41069NU Nitroreductase BED35_13070 ENOG4105D07 Signal peptide peptidase, SppA BED35_13075 ENOG4105HDK L-asparaginase BED35_13080 ENOG4108RWI nicotinamidase BED35_13095 ENOG4105E0X reductase BED35_13105 ENOG4105DSB aldose 1-epimerase BED35_13110 ENOG4105GNX MltA-interacting MipA family protein BED35_13115 ENOG4105CYN Serine protein kinase BED35_13120 ENOG4106AKX UPF0229 protein BED35_13135 ENOG4105HEI LysR family (Transcriptional regulator BED35_13140 ENOG4105EUB pirin domain protein BED35_13145 ENOG4105BZU Histidine kinase BED35_13155 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BED35_13160 ENOG4105MWK D-amino acid dehydrogenase, small subunit BED35_13165 ENOG4105ED1 spovr family BED35_13170 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BED35_13175 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BED35_13180 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BED35_13200 ENOG4106N3A copper homeostasis protein cutc BED35_13205 ENOG4106ZCM YecM protein BED35_13210 ENOG4105C75 arginyL-tRNA synthetase BED35_13220 ENOG4105D5M phosphate starvation-inducible protein BED35_13235 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD BED35_13240 ENOG4105CND Glycosyl transferase, family 2 BED35_13255 ENOG4105H1N peptidase, M24 BED35_13265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BED35_13290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED35_13300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED35_13315 ENOG4107SJW iron permease, FTR1 BED35_13330 ENOG4105CSV Glutaminase BED35_13335 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BED35_13340 ENOG4105FB2 class II Aldolase BED35_13345 ENOG4105G63 Type III effector Hrp-dependent BED35_13350 ENOG4105MVE transcriptional regulator BED35_13355 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BED35_13360 ENOG4108MRH transcriptional regulatory protein BED35_13370 ENOG4105C85 amino acid BED35_13385 ENOG4106UW1 Major Facilitator superfamily BED35_13390 ENOG4108HCJ Hydrolase BED35_13400 ENOG4105D5G Transposase BED35_13405 ENOG4108WF3 methyltransferase BED35_13415 ENOG4105D5G Transposase BED35_13460 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED35_13465 ENOG4105NKT exported protein BED35_13470 ENOG4108PNC copper resistance BED35_13475 ENOG4105FXM Copper resistance protein BED35_13480 ENOG41090A1 ferritin BED35_13485 ENOG4105MPK DNA polymerase III subunit theta BED35_13495 ENOG4105UMD exodeoxyribonuclease X BED35_13500 ENOG4105CUG Oligopeptidase b BED35_13510 ENOG4105N5Z UPF0267 protein BED35_13515 ENOG4105X2V dna damage-inducible protein BED35_13520 ENOG4105C1J atp-dependent rna helicase BED35_13525 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BED35_13530 ENOG4105X5C UPF0181 protein BED35_13540 ENOG4105P8F nudix hydrolase BED35_13545 ENOG4105EJQ L-serine dehydratase BED35_13550 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_13555 ENOG4105EE5 Membrane protein terC BED35_13560 ENOG4108EQA pts system BED35_13565 ENOG4105ETZ PTS System BED35_13570 ENOG4105F3R pts system mannose fructose sorbose family iid BED35_13575 ENOG4108NK4 UPF0266 membrane protein BED35_13580 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) BED35_13590 ENOG4105BZU Histidine kinase BED35_13600 ENOG4105DHI Methyltransferase BED35_13605 ENOG4105CJN penicillin-binding protein BED35_13610 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BED35_13615 ENOG4105VEQ Cold shock protein BED35_13620 ENOG410610J Protein of unknown function (DUF2627) BED35_13625 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) BED35_13645 ENOG41064PC BED35_13650 ENOG4105TIK BED35_13655 ENOG4105N4N Protein of unknown function (DUF2766) BED35_13670 ENOG4105D5Q Arginine ornithine antiporter BED35_13680 ENOG4105BZ1 (ABC) transporter BED35_13710 ENOG4105XXV Acid-resistance protein BED35_13715 ENOG4105VTN Protein of unknown function (DUF1311) BED35_13725 ENOG4105DWP Membrane BED35_13740 ENOG4105KVH Transcriptional regulator BED35_13745 ENOG4105ECR NmrA family BED35_13750 ENOG4108IQK o-acetylhomoserine BED35_13760 ENOG4105KT5 UmuD protein BED35_13765 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BED35_13770 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BED35_13780 ENOG4106NDP Transcriptional regulator BED35_13785 ENOG4108HKT sucrose-6-phosphate hydrolase BED35_13790 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BED35_13805 ENOG4108HMX isocitrate dehydrogenase (NADP) BED35_13835 ENOG4108HMX isocitrate dehydrogenase (NADP) BED35_13840 ENOG4108R99 pseudouridine synthase BED35_13850 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BED35_13855 ENOG41075W9 High frequency lysogenization protein HflD homolog BED35_13860 ENOG4107QTF adenylosuccinate lyase BED35_13870 ENOG4105XJC Two component transcriptional regulator (Winged helix family BED35_13890 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BED35_13900 ENOG4105D60 lipoprotein releasing system transmembrane protein BED35_13910 ENOG4105D60 lipoprotein releasing system transmembrane protein BED35_13915 ENOG4108JA2 transcriptioN-repair coupling factor BED35_13920 ENOG4107MBR 17 kDa surface antigen BED35_13925 ENOG4105CEP NADH dehydrogenase BED35_13930 ENOG4105D0Y UPF0227 protein BED35_13935 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BED35_13940 ENOG4108RUM thiamine kinase BED35_13945 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) BED35_13950 ENOG41090DQ Lipoprotein BED35_13955 ENOG4105K59 histidine triad (HIT) protein BED35_13960 ENOG4105F9E Shikimate 5-dehydrogenase BED35_13970 ENOG4105C4X radical SAM domain protein BED35_13980 ENOG4108JJA ABC, transporter BED35_13990 ENOG4105CI1 PTS System BED35_13995 ENOG4105F8V Hydrolase, tatD family BED35_14000 ENOG4107QRG dna polymerase iii BED35_14005 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BED35_14010 ENOG4105HHA aminodeoxychorismate lyase BED35_14015 ENOG4105YAZ 4-amino-4-deoxychorismate lyase BED35_14020 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED35_14030 ENOG4105CHR reductase BED35_14035 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BED35_14040 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BED35_14045 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BED35_14050 ENOG4105VGS 50s ribosomal protein l32 BED35_14055 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BED35_14065 ENOG4105EI2 Pseudouridine synthase BED35_14070 ENOG4107QQB Ribonuclease E BED35_14075 ENOG41067V3 Antibiotic biosynthesis monooxygenase BED35_14080 ENOG4105EKE dihydroorotase BED35_14090 ENOG4105PVA Biofilm formation regulatory protein BssS BED35_14105 ENOG4105DSF transport protein BED35_14110 ENOG4105C72 UPF0176 protein BED35_14120 ENOG4106WHD Tetrathionate reductase BED35_14125 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED35_14135 ENOG4108ZXC Two component transcriptional regulator, luxr family BED35_14140 ENOG4105D1S lipid A biosynthesis BED35_14150 ENOG4108VGI doxx family BED35_14160 ENOG4105C6X Major Facilitator BED35_14165 ENOG4105DUX Transporter BED35_14170 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) BED35_14175 ENOG4105DJ9 glucan biosynthesis protein BED35_14190 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_14195 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) BED35_14205 ENOG4107YC3 synthase BED35_14210 ENOG4105VJY transcriptional regulator BED35_14215 ENOG4108W0S formate-dependent nitrite reductase complex BED35_14225 ENOG4107QX9 Thiol disulfide interChange protein BED35_14235 ENOG4105DVI reductase, NrfD BED35_14240 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED35_14245 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit BED35_14250 ENOG4105EAU Plays a role in nitrite reduction (By similarity) BED35_14260 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BED35_14265 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 BED35_14280 ENOG4105DR4 Methyltransferase BED35_14285 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) BED35_14290 ENOG4105K4P CoA-binding domain protein BED35_14295 ENOG4108Q67 UPF0319 protein BED35_14300 ENOG4108Z5K methylglyoxal synthase BED35_14305 ENOG41088T4 Helicase IV BED35_14310 ENOG410901E Membrane BED35_14315 ENOG4105EM2 membrane BED35_14320 ENOG4108RZ1 DNA transformation protein BED35_14330 ENOG4105UYK outer membrane protein a BED35_14335 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) BED35_14340 ENOG4105DAN ATP-dependent protease BED35_14345 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BED35_14355 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED35_14360 ENOG4108Q2G (LipO)protein BED35_14365 ENOG4105DY2 Paraquat-inducible protein b BED35_14370 ENOG4105F1S paraquat-inducible protein a BED35_14375 ENOG4105C5H ABC transporter BED35_14380 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BED35_14385 ENOG4105QVC MOSC domain-containing protein BED35_14390 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) BED35_14395 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BED35_14400 ENOG4105CD8 aminopeptidase N BED35_14405 ENOG4107RH7 Nicotinate phosphoribosyltransferase BED35_14410 ENOG4105C5S asparaginyl-tRNA synthetase BED35_14420 ENOG4105CGF Aromatic amino acid aminotransferase BED35_14430 ENOG4105C5X domain protein BED35_14435 ENOG4105EAQ (twin-arginine translocation) pathway signal BED35_14440 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BED35_14445 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) BED35_14450 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BED35_14455 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) BED35_14460 ENOG4106371 Methyltransferase BED35_14465 ENOG4107S90 membrAne BED35_14470 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups BED35_14475 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BED35_14480 ENOG4105W49 UPF0434 protein BED35_14485 ENOG4105VEQ Cold shock protein BED35_14490 ENOG4105VEQ Cold shock protein BED35_14495 ENOG4105E32 cytoplasmic protein BED35_14500 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BED35_14510 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BED35_14515 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BED35_14520 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BED35_14525 ENOG4105CAT Cytidine monophosphate kinase BED35_14530 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BED35_14535 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BED35_14540 ENOG4107VMU Membrane BED35_14545 ENOG4105HDK L-asparaginase BED35_14550 ENOG4105DDY UPF0142 protein ycaO BED35_14555 ENOG4105TMB Formate nitrite transporter BED35_14560 ENOG4105C6N Formate acetyltransferase BED35_14565 ENOG4105F1A Pyruvate formate-lyase BED35_14570 ENOG4108ISG Major Facilitator BED35_14575 ENOG4105D5G Transposase BED35_14585 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_14590 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BED35_14595 ENOG4105D1H recombination factor protein RarA BED35_14600 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BED35_14605 ENOG4105CNU cell division protein FtsK BED35_14610 ENOG4105EW9 transcriptional regulator AsnC family BED35_14615 ENOG4105C3M thioredoxin reductase BED35_14620 ENOG4108JJ9 ABC, transporter BED35_14625 ENOG4108JJ8 (ABC) transporter BED35_14630 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BED35_14635 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BED35_14640 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BED35_14645 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BED35_14650 ENOG4105VEQ Cold shock protein BED35_14660 ENOG4105DJY efflux transporter, rnd family, mfp subunit BED35_14665 ENOG4108MJ5 VirK protein BED35_14670 ENOG4105CPB ATP-dependent endonuclease of the OLD family BED35_14675 ENOG4105DWU Membrane BED35_14680 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BED35_14685 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BED35_14690 ENOG4105C7K acetolactate synthase BED35_14700 ENOG4105C5W Aldolase BED35_14705 ENOG4105CGD Nad-dependent epimerase dehydratase BED35_14710 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BED35_14715 ENOG41064MM (LipO)protein BED35_14720 ENOG4105E5Z arginine transporter ATP-binding subunit BED35_14725 ENOG4106PMH Extracellular solute-binding protein family 3 BED35_14730 ENOG4105GBT ABC transporter BED35_14735 ENOG4105DMR ABC, transporter BED35_14740 ENOG4106TNF Periplasmic binding protein BED35_14745 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BED35_14750 ENOG4105RBQ inner membrane protein ybjO BED35_14755 ENOG4105D38 putrescine abc transporter BED35_14760 ENOG4105F38 ABC transporter, permease BED35_14765 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED35_14770 ENOG4107RUE extracellular solute-binding protein family 1 BED35_14775 ENOG4108RMJ sensory transduction regulator BED35_14780 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress BED35_14785 ENOG41090BQ Glutaredoxin BED35_14790 ENOG4105D0C transport protein BED35_14800 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BED35_14805 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BED35_14810 ENOG4107FB0 transcriptional regulator DeoR family BED35_14815 ENOG4105C44 Serine transporter BED35_14820 ENOG4105EJQ L-serine dehydratase BED35_14825 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_14830 ENOG4105DZ1 carboxypeptidase BED35_14840 ENOG4105C28 cystathionine BED35_14845 ENOG4108UMI ABC transporter, permease BED35_14855 ENOG4105D01 (LipO)protein BED35_14870 ENOG4108TGY Glutathione S-transferase BED35_14875 ENOG4105D05 Receptor BED35_14885 ENOG4105EHG Permease protein BED35_14890 ENOG4108IQI permease BED35_14895 ENOG4105DUM transcriptional regulator, lysR family BED35_14910 ENOG4105HMI Membrane BED35_14915 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BED35_14920 ENOG4108D1K outer membrane usher protein BED35_14925 ENOG4108UIF Chaperone BED35_14940 ENOG4108SGD regulatory protein BED35_14945 ENOG4105DM4 PTS System BED35_14950 ENOG4105DE4 1-phosphofructokinase BED35_14955 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BED35_14965 ENOG4105CUW cytochrome C-TYPE protein BED35_14970 ENOG4107QY8 reductase BED35_14985 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BED35_14990 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BED35_15000 ENOG4105DEI Mannitol dehydrogenase BED35_15005 ENOG4107YCY Transcriptional regulator BED35_15015 ENOG4105CKI cobalamin synthesis protein BED35_15020 ENOG41076MN Phosphoesterase, PA-phosphatase related BED35_15025 ENOG4107TT5 NLP P60 protein BED35_15035 ENOG4105CXC rtn protein BED35_15040 ENOG4105E43 Extracellular solute-binding protein, family 5 BED35_15045 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BED35_15050 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BED35_15055 ENOG4108JQ5 ABC transporter BED35_15060 ENOG4105HG6 BED35_15065 ENOG4105C2C drug resistance transporter, Bcr CflA BED35_15070 ENOG4105I08 Pseudouridine synthase BED35_15075 ENOG4105CFI type iii restriction protein res subunit BED35_15080 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BED35_15085 ENOG4106V8H Nucleoid-associated protein BED35_15090 ENOG4105PAN UPF0352 protein BED35_15095 ENOG4105E68 Sulfatase BED35_15115 ENOG4105D5G Transposase BED35_15145 ENOG4108UHE carbonic anhydrase BED35_15150 ENOG4105CS2 ec 3.2.1.21 BED35_15155 ENOG4105C5Y PTS System BED35_15160 ENOG4108Q3X Transcriptional regulator BED35_15180 ENOG4105HRS Antitermination protein BED35_15190 ENOG4105Y50 Virulence Protein BED35_15200 ENOG4105C8Q Methyl-accepting chemotaxis BED35_15210 ENOG4105CT4 transporter BED35_15215 ENOG4107R6D beta-lactam binding protein AmpH BED35_15235 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BED35_15245 ENOG4106UW1 Major Facilitator superfamily BED35_15250 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC BED35_15255 ENOG41068CG regulatoR BED35_15260 ENOG4105BZU Histidine kinase BED35_15265 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED35_15270 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BED35_15275 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BED35_15280 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BED35_15290 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) BED35_15310 ENOG4105E0U tyrosine-specific transport protein BED35_15315 ENOG4108UII YfaZ family BED35_15320 ENOG4105CH6 catalase BED35_15325 ENOG4105CEY Amp-dependent synthetase and ligase BED35_15330 ENOG4105DNI Converts SHCHC to OSB (By similarity) BED35_15335 ENOG4108IPT Naphthoate synthase BED35_15340 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BED35_15345 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BED35_15350 ENOG4105E4F Isochorismate synthase BED35_15355 ENOG4105TNS Conserved Protein BED35_15360 ENOG4105C01 Dihydroxy-acid dehydratase BED35_15365 ENOG41090KN UPF0303 protein BED35_15375 ENOG4105C5I Dehydrogenase BED35_15380 ENOG4105K2J Transcriptional regulator BED35_15385 ENOG4105CHR reductase BED35_15390 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BED35_15400 ENOG4108UQ5 membrane protein YcdZ BED35_15410 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED35_15415 ENOG4105C8S subunit m BED35_15420 ENOG4105D65 subunit l BED35_15425 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED35_15430 ENOG4107UFS subunit j BED35_15435 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED35_15440 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BED35_15445 ENOG4108IEH NADH dehydrogenase subunit g BED35_15450 ENOG4107QIZ NADH dehydrogenase BED35_15455 ENOG4105GKE subunit e BED35_15460 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED35_15465 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED35_15470 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BED35_15475 ENOG4107NQ8 LysR family Transcriptional regulator BED35_15480 ENOG4105CHM Aminotransferase BED35_15485 ENOG4105DK2 UPF0207 protein BED35_15490 ENOG4107QWE )-transporter BED35_15500 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 BED35_15505 ENOG4105XWI UPF0304 protein BED35_15510 ENOG4105PQ6 UPF0208 membrane protein BED35_15520 ENOG4105C6K Malic enzyme BED35_15525 ENOG4107P2S Transcriptional regulator BED35_15530 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BED35_15540 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BED35_15545 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_15550 ENOG4105PTV Nudix Hydrolase BED35_15565 ENOG4105ECP epimerase BED35_15575 ENOG4108JEH abc transporter atp-binding protein BED35_15580 ENOG4106YG3 ABC transporter BED35_15585 ENOG4105DSP amino acid AbC transporter BED35_15590 ENOG4105E89 ABC transporter BED35_15595 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BED35_15600 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BED35_15605 ENOG4105E96 Colicin v production protein BED35_15610 ENOG4108S3P Sporulation domain protein BED35_15615 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BED35_15620 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BED35_15625 ENOG4105DQR SNARE associated Golgi BED35_15635 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BED35_15640 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BED35_15660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED35_15665 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BED35_15675 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BED35_15685 ENOG4106WZ1 flagella biosynthesis regulator BED35_15690 ENOG4105F4P )-transporter BED35_15695 ENOG4105D6F Phosphatase BED35_15700 ENOG4105ETE Transcriptional regulator (LacI family BED35_15710 ENOG4105CK1 PTS System BED35_15715 ENOG4105CS2 ec 3.2.1.21 BED35_15720 ENOG4105VCP PTS System BED35_15740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED35_15745 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BED35_15750 ENOG4105MH2 YfcL protein BED35_15755 ENOG4108BPE -transporting atpase BED35_15760 ENOG4105EJ9 Membrane BED35_15765 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BED35_15770 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BED35_15775 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BED35_15780 ENOG4108DG9 Smr protein MutS2 BED35_15785 ENOG4108BY2 phosphohistidine phosphatase BED35_15790 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BED35_15795 ENOG4105CHU acetyl-coa acetyltransferase BED35_15800 ENOG4105KZW UPF0381 protein BED35_15805 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BED35_15810 ENOG410903C (LipO)protein BED35_15815 ENOG4105KWW Biogenesis protein BED35_15820 ENOG4108M1T Cytochrome c-type biogenesis protein BED35_15825 ENOG4107QX9 Thiol disulfide interChange protein BED35_15830 ENOG4105DA4 cytochrome c-type biogenesis protein BED35_15835 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BED35_15840 ENOG4105X3C heme exporter protein BED35_15845 ENOG41060IM Heme exporter protein BED35_15850 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BED35_15860 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_15865 ENOG4105S64 Formate nitrite transporter BED35_15875 ENOG4105DFP Integrase BED35_15935 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BED35_15940 ENOG4105NTW Transcriptional regulator BED35_15950 ENOG4105CS2 ec 3.2.1.21 BED35_15955 ENOG4105C5Y PTS System BED35_15960 ENOG4105DDV Transcriptional regulator (LacI family BED35_15965 ENOG4108YYC ycei family BED35_15970 ENOG4105DS1 cytochrome b561 BED35_15995 ENOG4105DHJ ABC, transporter BED35_16020 ENOG4105CUB amino acid BED35_16025 ENOG4105CVE Lytic murein transglycosylase BED35_16040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED35_16055 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin BED35_16060 ENOG4108VKM cytochrome b561 BED35_16065 ENOG4105CHM Aminotransferase BED35_16075 ENOG41072TH Protein of unknown function (DUF1479) BED35_16085 ENOG4105DY9 regulatoR BED35_16095 ENOG4105CHC glucokinase (EC 2.7.1.2) BED35_16105 ENOG4105C5Q Transcriptional regulator BED35_16110 ENOG4107RA9 decarboxylase BED35_16115 ENOG4105CPC Aldo Keto reductase BED35_16125 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BED35_16130 ENOG4105D9N nucleoside BED35_16160 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BED35_16185 ENOG4105VRT cytoplasmic protein BED35_16190 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BED35_16205 ENOG4105C6T cysteine synthase BED35_16210 ENOG4105KZ7 phosphocarrier protein hpr BED35_16215 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BED35_16220 ENOG4105C5Y PTS System BED35_16225 ENOG4105E0F Histidine kinase BED35_16230 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED35_16235 ENOG4105DJY efflux transporter, rnd family, mfp subunit BED35_16245 ENOG4105C6T cysteine synthase BED35_16255 ENOG4105ECW sulfate abc transporter BED35_16260 ENOG4108I5D sulfate abc transporter BED35_16265 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein BED35_16275 ENOG4105QEK Transcriptional regulator BED35_16280 ENOG4108R66 Conserved Protein BED35_16300 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_16305 ENOG4105EZR dyp-type peroxidase family protein BED35_16310 ENOG4105E7K (LipO)protein BED35_16315 ENOG4105H4F exported protein BED35_16320 ENOG4108R6G acetyltransferase BED35_16325 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BED35_16330 ENOG4108UPT UPF0178 protein BED35_16340 ENOG4105C6K Malic enzyme BED35_16345 ENOG4107VIJ nudix hydrolase BED35_16355 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) BED35_16360 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BED35_16365 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase BED35_16375 ENOG4105WH1 Two component transcriptional regulator luxr family BED35_16385 ENOG4105BZS acriflavin resistance protein BED35_16405 ENOG4105KUZ arsenate reductase BED35_16410 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BED35_16420 ENOG4105XYK UPF0370 protein BED35_16435 ENOG4108T1M outer membrane protein x BED35_16450 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_16455 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED35_16460 ENOG4106KED esterase YpfH BED35_16470 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) BED35_16475 ENOG4108VMM UPF0756 membrane protein BED35_16480 ENOG4105CGZ zinc metallopeptidase BED35_16485 ENOG4105C8V SAICAR synthetase BED35_16490 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BED35_16495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BED35_16500 ENOG4105RH4 Glycine cleavage system transcriptional repressor BED35_16505 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BED35_16510 ENOG4105C02 permease BED35_16515 ENOG4105ERG peptidase m48, ste24p BED35_16520 ENOG4105K89 arsenate reductase BED35_16525 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BED35_16530 ENOG4105C2W permease BED35_16535 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BED35_16545 ENOG4108V3E phosphoribosylglycinamide formyltransferase BED35_16550 ENOG4108MK9 spermidine N(1)-acetyltransferase BED35_16555 ENOG4108C80 FliB family BED35_16565 ENOG4105E2Z phosphate ABC transporter (Permease BED35_16570 ENOG4105C8U phosphate abc transporter BED35_16580 ENOG4105C9X ppx gppa phosphatase BED35_16595 ENOG4105BZU Histidine kinase BED35_16600 ENOG4105R8A Heat shock protein BED35_16605 ENOG4105ENT Efflux transporter rnd family, mfp subunit BED35_16615 ENOG4105BZS acriflavin resistance protein BED35_16620 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED35_16625 ENOG4105EB3 Histidine kinase BED35_16630 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED35_16635 ENOG4105KWI UPF0339 protein BED35_16640 ENOG4105CFP Peptidase U32 BED35_16645 ENOG4107TE5 Lipid kinase BED35_16650 ENOG410787A Pts system, glucitol sorbitol-specific BED35_16655 ENOG4105DZY Pts system, glucitol sorbitol-specific BED35_16660 ENOG4105VI0 Pts system, glucitol sorbitol-specific BED35_16665 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase BED35_16670 ENOG4105J92 DNA-binding transcriptional activator GutM BED35_16675 ENOG410804X Transcriptional regulator BED35_16680 ENOG4105C2X Arabinose 5-phosphate isomerase BED35_16685 ENOG4108ZGU inhibitor of vertebrate lysozyme BED35_16695 ENOG4105DWF phosphomethylpyrimidine kinase BED35_16725 ENOG4105D5G Transposase BED35_16765 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_16790 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BED35_16795 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BED35_16800 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BED35_16805 ENOG4105VPD cellular component movement BED35_16815 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_16820 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BED35_16830 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BED35_16840 ENOG4105CUT histidyl-tRNA synthetase BED35_16845 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BED35_16850 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BED35_16860 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BED35_16875 ENOG4108JQB penicillin-binding protein 1C BED35_16880 ENOG4105DN3 alpha-2-macroglobulin domain protein BED35_16885 ENOG4108MGN ATP-binding component of a transport system BED35_16890 ENOG4105YYA enhanced serine sensitivity protein SseB BED35_16900 ENOG4105WVQ Fe-S assembly protein IscX BED35_16905 ENOG4108ZIT Ferredoxin, 2FE-2S BED35_16910 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BED35_16915 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BED35_16920 ENOG4108Z4V iron-sulfur cluster assembly BED35_16925 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BED35_16930 ENOG4105C3J Cysteine desulfurase BED35_16935 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BED35_16940 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BED35_16950 ENOG4105D7X high-affinity nickel-transporter BED35_16955 ENOG41065CD Exported protein BED35_16965 ENOG4105D8G Major Facilitator superfamily BED35_16970 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BED35_16975 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BED35_16980 ENOG4108M21 BED35_16985 ENOG4105RMW regulation of transcription, DNA-dependent BED35_16990 ENOG4108626 Racemase BED35_16995 ENOG41080QX K07048 phosphotriesterase-related protein BED35_17000 ENOG4105MUZ Protein of unknown function DUF2620 BED35_17010 ENOG4108YZA Nitrogen regulatory protein pii BED35_17015 ENOG4105C4K Nad synthetase BED35_17020 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BED35_17025 ENOG4108SKK alpha helix protein BED35_17030 ENOG4107WP9 Histidine kinase BED35_17045 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BED35_17050 ENOG4108Z6B deaminase BED35_17060 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB BED35_17070 ENOG4106G6Q Transcriptional regulator BED35_17075 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BED35_17085 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BED35_17090 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BED35_17095 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BED35_17100 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BED35_17105 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BED35_17110 ENOG4105C3F Signal peptidase i BED35_17115 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BED35_17125 ENOG4105WMJ Positive regulator of sigma E, RseC MucC BED35_17130 ENOG4105VQK sigma E regulatory protein, MucB RseB BED35_17135 ENOG41069PW sigma-e factor negative regulatory protein BED35_17145 ENOG4108IYU L-aspartate oxidase BED35_17150 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BED35_17155 ENOG4105C1J atp-dependent rna helicase BED35_17160 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_17165 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_17185 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) BED35_17190 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BED35_17195 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BED35_17200 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BED35_17205 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BED35_17210 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BED35_17220 ENOG4108Z1B Cyclase dehydrase BED35_17225 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BED35_17240 ENOG4105CHH sulfate transporter BED35_17245 ENOG410901P UPF0249 protein BED35_17250 ENOG4105EZV Transcriptional regulator BED35_17255 ENOG4105VCP PTS System BED35_17260 ENOG4105CS2 ec 3.2.1.21 BED35_17265 ENOG4105CK1 PTS System BED35_17270 ENOG4105VZJ PTS System BED35_17280 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_17285 ENOG4105CPC Aldo Keto reductase BED35_17295 ENOG41086WQ Protein CrcB homolog BED35_17300 ENOG4107SVH Potassium channel protein BED35_17305 ENOG4105XXV Acid-resistance protein BED35_17320 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BED35_17325 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BED35_17330 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BED35_17340 ENOG4105CQM Urea amidohydrolase subunit alpha BED35_17345 ENOG4105KI2 Urea amidohydrolase subunit beta BED35_17355 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) BED35_17365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED35_17405 ENOG4105VEQ Cold shock protein BED35_17420 ENOG4108WMJ Protein of unknown function (DUF2002) BED35_17425 ENOG4105F9N Major Facilitator Superfamily BED35_17430 ENOG41075H3 AraC family transcriptional regulator BED35_17445 ENOG4105TNS Conserved Protein BED35_17455 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BED35_17465 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BED35_17475 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BED35_17480 ENOG4108IJ7 Glycine betaine BED35_17485 ENOG4108HQS Glycine betaine BED35_17490 ENOG4105GIJ Glycine betaine BED35_17500 ENOG4108JDX DNA polymerase iii, epsilon subunit BED35_17505 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BED35_17510 ENOG4105D1A Methyltransferase BED35_17515 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BED35_17520 ENOG4105E9H Lytic Murein transglycosylase BED35_17525 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_17530 ENOG4107NA1 Endonuclease Exonuclease phosphatase BED35_17535 ENOG4105F27 Major Facilitator BED35_17540 ENOG4105HEI LysR family (Transcriptional regulator BED35_17545 ENOG4105CV8 reductase BED35_17555 ENOG4105D5G Transposase BED35_17600 ENOG4108UMI ABC transporter, permease BED35_17605 ENOG4105D01 (LipO)protein BED35_17610 ENOG4108R8X outer membrane lipoprotein BED35_17615 ENOG4108R96 Methyltransferase, YaeB family BED35_17620 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BED35_17625 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion BED35_17630 ENOG4108YZN class I peptide chain release factor BED35_17635 ENOG4108VWS Yaeq family BED35_17645 ENOG4105M1T rho-binding antiterminator BED35_17650 ENOG4105N7H Cytochrome BED35_17655 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BED35_17660 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BED35_17665 ENOG4105CXN decarboxylase BED35_17670 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BED35_17675 ENOG4105C0B DNA polymerase III (alpha subunit) BED35_17680 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BED35_17685 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BED35_17695 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BED35_17700 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BED35_17705 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) BED35_17715 ENOG4105DZP Membrane-associated zinc metalloprotease BED35_17720 ENOG4105KNE Phosphatidate cytidylyltransferase BED35_17725 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BED35_17730 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BED35_17735 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BED35_17740 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BED35_17745 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BED35_17750 ENOG4105CE9 30S ribosomal protein S2 BED35_17760 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BED35_17765 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BED35_17770 ENOG4108T8E UPF0325 protein BED35_17775 ENOG4105QDK Flavodoxin BED35_17780 ENOG4105DR9 pseudouridine synthase BED35_17785 ENOG4105WP7 tRNA pseudouridine synthase C BED35_17790 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BED35_17795 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BED35_17800 ENOG4105EWT decarboxylase family BED35_17805 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease BED35_17810 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_17815 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) BED35_17820 ENOG4105M08 Membrane BED35_17825 ENOG4105ETT transcriptional Regulator, LysR family BED35_17830 ENOG4105M5B (LipO)protein BED35_17835 ENOG4105C9B Cysteine desulfurase BED35_17840 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BED35_17845 ENOG4105CUZ uba thif-type nad fad binding protein BED35_17850 ENOG4105CA3 membrane-bound lytic murein transglycosylase BED35_17870 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BED35_17875 ENOG4107QZM n-acetylglutamate synthase BED35_17880 ENOG4107QYX exodeoxyribonuclease v alpha BED35_17885 ENOG4107QKA exodeoxyribonuclease V beta BED35_17890 ENOG4107QXK peptidase BED35_17895 ENOG4105DSY exodeoxyribonuclease V, gamma BED35_17900 ENOG4105RVB Prepilin peptidase dependent protein c BED35_17920 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BED35_17925 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BED35_17930 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BED35_17945 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) BED35_17950 ENOG4105EE5 Membrane protein terC BED35_17955 ENOG4105CPC Aldo Keto reductase BED35_17965 ENOG4105CEY Amp-dependent synthetase and ligase BED35_17975 ENOG41060NJ transcriptional regulator BED35_17980 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BED35_17985 ENOG4105RQF LysR family Transcriptional regulator BED35_17990 ENOG4105F27 Major Facilitator BED35_18060 ENOG4108VAU general secretion pathway protein G BED35_18070 ENOG4107QHF type ii secretion system protein e BED35_18090 ENOG4107B2H carbonic anhydrase BED35_18095 ENOG4105KVH Transcriptional regulator BED35_18100 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BED35_18110 ENOG4105DVC DnaJ domain protein BED35_18115 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_18120 ENOG4105BZU Histidine kinase BED35_18125 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein BED35_18140 ENOG4105D5G Transposase BED35_18145 ENOG4105WJ3 XRE family Transcriptional regulator BED35_18150 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation BED35_18170 ENOG4108KU9 integrase family BED35_18255 ENOG4105CRK lysyL-tRNA synthetase BED35_18260 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BED35_18265 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BED35_18270 ENOG4105T95 Thiol disulfide interChange protein BED35_18275 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED35_18280 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) BED35_18285 ENOG4105CT7 inner membrane cred family protein BED35_18290 ENOG4105EB3 Histidine kinase BED35_18295 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED35_18305 ENOG4105Y75 tpr repeat protein BED35_18310 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BED35_18315 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_18320 ENOG4108UT2 hemolysin iii BED35_18330 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BED35_18340 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BED35_18345 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BED35_18350 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BED35_18355 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BED35_18360 ENOG4105D0A hydroxylase BED35_18365 ENOG4107RAQ aminopeptidase BED35_18370 ENOG4105E07 UPF0149 protein BED35_18375 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BED35_18385 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BED35_18390 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BED35_18395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BED35_18400 ENOG4105DXN mazG family BED35_18405 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BED35_18410 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BED35_18415 ENOG4105BZU Histidine kinase BED35_18420 ENOG4105C0H protease BED35_18425 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BED35_18430 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BED35_18440 ENOG4105EN6 Membrane BED35_18445 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BED35_18455 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BED35_18460 ENOG4105DQQ Major facilitator superfamily MFS_1 BED35_18465 ENOG4105S6R Iron-hydroxamate transporter permease subunit BED35_18470 ENOG4105J76 Periplasmic binding protein BED35_18475 ENOG4105E0A ABC, transporter BED35_18480 ENOG4105BZ4 penicillin-binding protein BED35_18485 ENOG4105CQ7 ATP-dependent helicase BED35_18490 ENOG4107XID 2'-5' rna ligase BED35_18495 ENOG4105PW4 Sugar fermentation stimulation protein homolog BED35_18500 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BED35_18510 ENOG4105DJ0 Poly(A) Polymerase BED35_18515 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BED35_18520 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BED35_18525 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BED35_18530 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BED35_18535 ENOG4107BJW polysaccharide deacetylase BED35_18540 ENOG4105E3A (ABC) transporter BED35_18545 ENOG4105DA5 (ABC) transporter BED35_18550 ENOG41077A9 carbonic anhydrase BED35_18555 ENOG4108UGV hypoxanthine phosphoribosyltransferase BED35_18560 ENOG4105E3B Multicopper oxidase BED35_18565 ENOG4108ZRK uncharacterized protein yacC BED35_18570 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BED35_18575 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BED35_18585 ENOG4105RPH Inner membrane protein YddG BED35_18590 ENOG4108ZIG UPF0231 protein BED35_18600 ENOG4107RNH Outer membrane receptor FepA BED35_18615 ENOG4107QN2 dihydrolipoyl dehydrogenase BED35_18620 ENOG4107QSN dihydrolipoamide acetyltransferase BED35_18625 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BED35_18630 ENOG41073TP transcriptional regulator BED35_18635 ENOG4105C85 amino acid BED35_18640 ENOG4106A72 regulatory protein AmpE BED35_18650 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BED35_18655 ENOG4108ZUW Major pilin subunit BED35_18660 ENOG4107QHF type ii secretion system protein e BED35_18665 ENOG4105D7Q type ii secretion system BED35_18670 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BED35_18675 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BED35_18685 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BED35_18690 ENOG4105M6F mutator MutT protein BED35_18695 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BED35_18700 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) BED35_18715 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BED35_18720 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BED35_18725 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BED35_18735 ENOG4105DFU Cell wall formation (By similarity) BED35_18740 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BED35_18745 ENOG4105CNI cell division protein FtsW BED35_18755 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BED35_18760 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BED35_18765 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BED35_18770 ENOG4105CJN penicillin-binding protein BED35_18780 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BED35_18785 ENOG4108V6E Cell division protein mraZ BED35_18795 ENOG4107B7Y DNA-binding transcriptional regulator FruR BED35_18800 ENOG4108ZP8 Acetolactate synthase small subunit BED35_18805 ENOG4105C7K acetolactate synthase BED35_18810 ENOG4108IQE Amp-dependent synthetase and ligase BED35_18815 ENOG41064T2 transcriptional regulator, lysR family BED35_18820 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BED35_18825 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BED35_18830 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BED35_18850 ENOG4105S8Q sugar efflux transporter BED35_18855 ENOG4105C6N Formate acetyltransferase BED35_18865 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BED35_18880 ENOG4105DP9 ABC transporter BED35_18885 ENOG4106SMU thiamine transporter membrane protein BED35_18895 ENOG4108KF1 Membrane BED35_18900 ENOG4105CQ2 DNA polymerase BED35_18905 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BED35_18915 ENOG4105D3G Pseudouridine synthase BED35_18920 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BED35_18925 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BED35_18930 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BED35_18940 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BED35_18945 ENOG4105NWN ApaG protein BED35_18950 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BED35_18955 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BED35_18960 ENOG4107XM3 UPF0442 protein BED35_18965 ENOG4105DWK Membrane BED35_18970 ENOG4105N14 lysine exporter protein LysE YggA BED35_18975 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BED35_18980 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BED35_18985 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BED35_18990 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BED35_18995 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BED35_19000 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BED35_19005 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BED35_19010 ENOG4105DTN riboflavin biosynthesis protein ribF BED35_19020 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BED35_19025 ENOG41063Z6 transcriptional regulator, lysR family BED35_19030 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BED35_19035 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BED35_19040 ENOG4105CFG Acts as a chaperone (By similarity) BED35_19045 ENOG4106HK8 GPR1 FUN34 yaaH family protein BED35_19060 ENOG4108RIR Molybdenum cofactor biosynthesis protein BED35_19065 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BED35_19070 ENOG4105D1Q UPF0246 protein BED35_19075 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_19085 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BED35_19095 ENOG410759A BED35_19100 ENOG41065U4 response regulator BED35_19105 ENOG4108RH0 Crea protein BED35_19110 ENOG4105UEI Transcriptional Regulator AraC Family BED35_19115 ENOG4105CVJ phosphoglycerate mutase BED35_19125 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) BED35_19130 ENOG4107SC1 transglycosylase BED35_19145 ENOG4108KHX Diguanylate cyclase BED35_19150 ENOG41090EK ompa motb domain protein BED35_19155 ENOG4105C5H ABC transporter BED35_19170 ENOG4105CIS alcohol dehydrogenase BED35_19185 ENOG4105EAC phosphoserine phosphatase BED35_19190 ENOG41062Z9 Membrane BED35_19195 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BED35_19200 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BED35_19205 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BED35_19210 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BED35_19215 ENOG4105D9N nucleoside BED35_19220 ENOG4105EYA deoxyribonuclease BED35_19225 ENOG4108NRW Phospholipase, patatin family BED35_19235 ENOG4105K3G Periplasmic Protein BED35_19240 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BED35_19245 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BED35_19250 ENOG4108WPU DNA polymerase III subunit psi BED35_19255 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BED35_19260 ENOG4105CPC Aldo Keto reductase BED35_19275 ENOG4105YBH Protein of unknown function (DUF1435) BED35_19280 ENOG4105BZU Histidine kinase BED35_19285 ENOG4105GAV receptor BED35_19295 ENOG4105D7K pfkb domain protein BED35_19310 ENOG4108HKT sucrose-6-phosphate hydrolase BED35_19315 ENOG4105WBN Transcriptional regulator (LacI family BED35_19320 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BED35_19370 ENOG4108UTZ Dihydroxyacetone kinase BED35_19375 ENOG4105CMT Dihydroxyacetone kinase BED35_19385 ENOG4105BZS acriflavin resistance protein BED35_19390 ENOG410624X efflux transporter, rnd family, mfp subunit BED35_19395 ENOG4105CEU Arginine dihydrolase BED35_19410 ENOG4105DKP glycosyl transferase, family 9 BED35_19415 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BED35_19420 ENOG4105DKT Transcriptional regulator BED35_19425 ENOG4105C2J ABC transporter BED35_19430 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BED35_19435 ENOG4105F5R ABC transporter BED35_19440 ENOG4105D4B ABC, transporter BED35_19445 ENOG41061GT Aldolase BED35_19450 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound BED35_19460 ENOG4105RI1 glycoprotein receptor BED35_19465 ENOG4105D5G Transposase BED35_19495 ENOG4108K5H permease YjgP YjgQ family protein BED35_19500 ENOG4108M8S permease YjgP YjgQ family protein BED35_19505 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BED35_19510 ENOG4105MYG DNA polymerase iii, chi subunit BED35_19520 ENOG4108MJ3 acetyltransferase BED35_19525 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) BED35_19535 ENOG4105XEP YhcH YjgK YiaL family protein BED35_19545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BED35_19550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED35_19555 ENOG4105C3U ABC transporter BED35_19560 ENOG4108JQ7 (ABC) transporter BED35_19575 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BED35_19590 ENOG4107RJJ Transcriptional regulator BED35_19595 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG BED35_19600 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH BED35_19605 ENOG4105EKV Phosphonate metabolism protein BED35_19610 ENOG4105FT8 Phosphonate metabolism BED35_19615 ENOG4105ENV phosphonate C-P lyase system protein PhnK BED35_19620 ENOG4105HRV phosphonate c-p lyase system protein phnl BED35_19625 ENOG4105FD8 phosphonate metabolism protein PhnM BED35_19635 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein BED35_19640 ENOG4105K4T epimerase BED35_19655 ENOG4108ZPB UPF0306 protein BED35_19670 ENOG4105DRS transport system, permease BED35_19675 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BED35_19690 ENOG4105EY3 heparinase II III family protein BED35_19695 ENOG4105CXN decarboxylase BED35_19700 ENOG4105D5Q Arginine ornithine antiporter BED35_19710 ENOG4108YYD acetyltransferase BED35_19715 ENOG4105XPQ lipid carrier protein BED35_19720 ENOG4105CFP Peptidase U32 BED35_19725 ENOG4106RZ4 Peptidase U32 BED35_19730 ENOG4105CEM UPF0597 protein BED35_19735 ENOG4105C44 Serine transporter BED35_19740 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BED35_19745 ENOG4105DEN Luciferase family BED35_19755 ENOG4105C1J atp-dependent rna helicase BED35_19765 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BED35_19770 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BED35_19775 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BED35_19780 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BED35_19785 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BED35_19790 ENOG4105CHV Transcription elongation factor NusA BED35_19795 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BED35_19815 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BED35_19820 ENOG4105EEI dihydropteroate synthase BED35_19825 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BED35_19830 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BED35_19835 ENOG4105HBR Rna-binding protein BED35_19840 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BED35_19845 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BED35_19860 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BED35_19865 ENOG4105QYV Membrane BED35_19870 ENOG4105K46 50S ribosomal protein l27 BED35_19875 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BED35_19880 ENOG4105EAH synthase BED35_19890 ENOG4105HVQ Regulatory factor of maltose metabolism BED35_19895 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BED35_19900 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) BED35_19910 ENOG4105DFU Cell wall formation (By similarity) BED35_19915 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BED35_19920 ENOG4105C8Q Methyl-accepting chemotaxis BED35_19925 ENOG4105F0N pyrophosphate phospho-hydrolase BED35_19930 ENOG4108ZHD aig2 family BED35_19945 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BED35_19950 ENOG4105C37 (CBS) domain BED35_19955 ENOG41061GZ Protein of unknown function (DUF1107) BED35_19960 ENOG4108UUE Transcriptional regulator BED35_19965 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BED35_19970 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BED35_19980 ENOG4108V1T peptidylprolyl cis-trans isomerase BED35_19985 ENOG4105FHY Opacity-associated protein A BED35_19995 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BED35_20000 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BED35_20005 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) BED35_20010 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BED35_20020 ENOG4108MXZ Esterase BED35_20025 ENOG4105WSB biofilm stress and motility protein A BED35_20030 ENOG4105CSU acyl-Coa dehydrogenase BED35_20035 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_20040 ENOG4105C2N RNA methyltransferase TrmH family group 3 BED35_20045 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BED35_20050 ENOG4105KPV Transcriptional regulator BED35_20055 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BED35_20065 ENOG4105EPW hflc protein BED35_20070 ENOG4107QJR hflk protein BED35_20075 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BED35_20080 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BED35_20085 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BED35_20090 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BED35_20095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BED35_20100 ENOG4105K8N protein family UPF0079, ATPase BED35_20105 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BED35_20110 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BED35_20125 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BED35_20130 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BED35_20135 ENOG4105DJ4 phosphatidylserine decarboxylase BED35_20140 ENOG4105EGS Mechanosensitive ion channel BED35_20145 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BED35_20160 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BED35_20165 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BED35_20175 ENOG4105KPY Small multidrug resistance protein BED35_20185 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BED35_20190 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BED35_20195 ENOG4108ZVF (LipO)protein BED35_20205 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BED35_20210 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BED35_20225 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BED35_20235 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BED35_20240 ENOG4105BZW Glycerate kinase BED35_20245 ENOG4108SIC Transcriptional regulator BED35_20255 ENOG4105C6N Formate acetyltransferase BED35_20260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BED35_20265 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) BED35_20270 ENOG4105C7B Threonine dehydratase BED35_20275 ENOG4105D4P Coproporphyrinogen iii oxidase BED35_20280 ENOG41090JE Utilization Protein BED35_20290 ENOG4107F3C Hemin uptake protein BED35_20295 ENOG4107ENK receptor BED35_20300 ENOG4106QJH hemin transport protein BED35_20305 ENOG4107R4I Periplasmic binding protein BED35_20310 ENOG4105EHG Permease protein BED35_20315 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BED35_20330 ENOG4105E0K tonB-dependent siderophore receptor BED35_20345 ENOG4105VTW prevent-host-death family BED35_20355 ENOG4105CQ0 ABC transporter BED35_20360 ENOG4105PE1 Receptor BED35_20365 ENOG4108S3W Anti-feci sigma factor, fecr BED35_20380 ENOG4105KSU Redox protein BED35_20385 ENOG41066VF YeeE YedE family protein BED35_20390 ENOG4108IUF type iii secretion BED35_20395 ENOG4108TN6 type iii secretion BED35_20400 ENOG41083GP type iii secretion BED35_20405 ENOG4108HHI Type III secretion system protein BED35_20410 ENOG41063Q7 Type III secretion system protein BED35_20425 ENOG4108JIR Flagellum-specific ATP synthase BED35_20435 ENOG4106H1D secretion system apparatus protein BED35_20440 ENOG4105UQF type iii secretion BED35_20500 ENOG4108SZ7 secretion system effector BED35_20545 ENOG4105WH1 Two component transcriptional regulator luxr family BED35_20550 ENOG4105CK2 sodium dicarboxylate symporter BED35_20555 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BED35_20560 ENOG41062QD Membrane BED35_20565 ENOG4107QN1 sodium solute BED35_20610 ENOG4105DC1 bifunctional purine biosynthesis protein purh BED35_20615 ENOG4105C12 Phosphoribosylglycinamide synthetase BED35_20620 ENOG4108T8B Protein of unknown function (DUF1481) BED35_20630 ENOG4105R2J Conserved Protein BED35_20635 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BED35_20640 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BED35_20645 ENOG4105E09 nadh pyrophosphatase BED35_20650 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor BED35_20655 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BED35_20665 ENOG4105D06 uba thif-type nad fad binding protein BED35_20670 ENOG4105WHD thiamine biosynthesis protein ThiS BED35_20675 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BED35_20680 ENOG4105D41 biosynthesis protein thiH BED35_20685 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_20690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BED35_20695 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BED35_20705 ENOG4108VZM 50s ribosomal protein L10 BED35_20710 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BED35_20715 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BED35_20720 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BED35_20725 ENOG4105PM1 preprotein translocase subunit SecE BED35_20730 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BED35_20765 ENOG4105CS9 pantothenic acid kinase BED35_20770 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BED35_20780 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_20810 ENOG4108RR8 protoporphyrinogen oxidase BED35_20815 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BED35_20820 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BED35_20825 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) BED35_20830 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BED35_20835 ENOG4105CHU acetyl-coa acetyltransferase BED35_20840 ENOG4107QK7 reductase BED35_20845 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BED35_20850 ENOG4105MDZ Transcriptional activator rfaH BED35_20855 ENOG4105D52 delta-aminolevulinic acid dehydratase BED35_20865 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BED35_20870 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BED35_20875 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BED35_20880 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BED35_20885 ENOG4105JC1 sterol-binding domain protein BED35_20890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BED35_20915 ENOG4108I5U Uridine phosphorylase BED35_20920 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) BED35_20925 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BED35_20930 ENOG4105DZ2 Transcriptional regulator BED35_20935 ENOG4105EMK carboxylate amino acid amine transporter BED35_20940 ENOG4105RK9 auxin efflux carrier BED35_20945 ENOG4107T6V glycerophosphoryl diester phosphodiesterase BED35_20950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED35_20955 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BED35_20960 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BED35_20965 ENOG4105BZ7 extracellular solute-binding protein family 1 BED35_21000 ENOG4108IV0 ABC, transporter BED35_21005 ENOG4105C0Z ABC transporter BED35_21010 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BED35_21015 ENOG4105C32 Amino acid ABC transporter (Permease) BED35_21020 ENOG4105CP9 extracellular ligand-binding receptor BED35_21025 ENOG4105U59 -acetyltransferase BED35_21045 ENOG4105CRP Part of the ABC transporter FtsEX involved in BED35_21050 ENOG4105CAK Cell division ATP-binding protein ftsE BED35_21055 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BED35_21060 ENOG4106H78 methyltransferase BED35_21065 ENOG4105MG3 Membrane BED35_21080 ENOG4107FS9 Membrane BED35_21085 ENOG4105C59 p-type ATPase BED35_21090 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BED35_21095 ENOG4105EX9 Membrane BED35_21100 ENOG4108W1V Lipoprotein BED35_21105 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BED35_21110 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B BED35_21115 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A BED35_21120 ENOG4105CXY transporter BED35_21125 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BED35_21130 ENOG4105DQF Hydrolase BED35_21135 ENOG4108EUD Lysophospholipase BED35_21145 ENOG4105CCF Lysine exporter protein (Lyse ygga) BED35_21150 ENOG4105C9U ATP-dependent DNA helicase RecQ BED35_21155 ENOG4105HDD phospholipase BED35_21160 ENOG4108VUY thioesterase Superfamily protein BED35_21165 ENOG4105FR1 rard protein BED35_21170 ENOG4107QUT magnesium and cobalt transport protein CorA BED35_21180 ENOG4105EQN UPF0261 protein BED35_21190 ENOG4105C4R Atp-dependent dna helicase BED35_21195 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant BED35_21200 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED35_21205 ENOG4105CT0 Protein of unknown function, DUF484 BED35_21210 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BED35_21215 ENOG4105S7Z (LipO)protein BED35_21220 ENOG4105XQ6 frataxin-like protein BED35_21235 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BED35_21240 ENOG41076E6 Uroporphyrinogen-III Synthase BED35_21245 ENOG4105ECF c-methyltransferase BED35_21250 ENOG410601J HemY protein BED35_21255 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_21295 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) BED35_21300 ENOG4105EGZ biosynthesis protein BED35_21305 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BED35_21310 ENOG4108WJ1 acetyltransferase BED35_21315 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BED35_21320 ENOG4105C1B dTDP-glucose 4-6-dehydratase BED35_21325 ENOG4108IJ1 Dehydrogenase BED35_21330 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BED35_21335 ENOG4105SFE lipopolysaccharide biosynthesis protein BED35_21340 ENOG4105ESV Glycosyl transferase, family 4 BED35_21345 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_21355 ENOG4105K63 Thioredoxin BED35_21365 ENOG4105C9X ppx gppa phosphatase BED35_21375 ENOG4105C4R Atp-dependent dna helicase BED35_21380 ENOG4105KQ5 peptidylprolyl cis-trans isomerase BED35_21410 ENOG4107R3N Filamentation induced by cAMP protein fic BED35_21445 ENOG4105DFP Integrase BED35_21450 ENOG4105T16 Transcriptional regulator (AraC family) BED35_21455 ENOG4107RNG ABC transporter BED35_21465 ENOG4105DFW ABC transporter BED35_21470 ENOG4105C93 Xylose Isomerase BED35_21475 ENOG4105CMG Carbohydrate kinase BED35_21480 ENOG4108TTM chaperone BED35_21495 ENOG4105MEV Acyl-transferase BED35_21505 ENOG4105EM7 Selenocysteine-specific translation elongation factor BED35_21510 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) BED35_21515 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) BED35_21520 ENOG4108MG3 formate dehydrogenase BED35_21525 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED35_21530 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BED35_21535 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BED35_21540 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BED35_21545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BED35_21550 ENOG4105C8Q Methyl-accepting chemotaxis BED35_21555 ENOG4108RPX mosc domain containing protein BED35_21560 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A BED35_21570 ENOG4108YYI Protein of unknown function (DUF2810) BED35_21575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED35_21585 ENOG4105E61 Mannitol repressor protein BED35_21590 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BED35_21595 ENOG4105CTS PTS system mannitol-specific BED35_21600 ENOG4106JH6 (LipO)protein BED35_21605 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BED35_21610 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BED35_21615 ENOG4108R3E Dna-3-methyladenine glycosylase i BED35_21620 ENOG4105HNP -acetyltransferase BED35_21650 ENOG4105C5I Dehydrogenase BED35_21655 ENOG4107T9C Alpha amylase catalytic region BED35_21660 ENOG4105JKW Valine--pyruvate aminotransferase BED35_21665 ENOG4105D0C transport protein BED35_21670 ENOG4105EQR Transposase IS116 IS110 IS902 BED35_21675 ENOG4105E5M Multidrug resistance protein D BED35_21690 ENOG4105DP0 ferredoxin-NADP reductase BED35_21695 ENOG4108VTS Membrane BED35_21700 ENOG4105EBK exported protein BED35_21705 ENOG4105CP7 Triose-phosphate isomerase BED35_21715 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BED35_21725 ENOG41076HS cation diffusion facilitator family transporter BED35_21730 ENOG4105FMW periplasmic BED35_21735 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED35_21740 ENOG4105E0F Histidine kinase BED35_21745 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BED35_21750 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BED35_21755 ENOG4105D7W serine acetyltransferase BED35_21760 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BED35_21765 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BED35_21770 ENOG4105VW4 glutaredoxin 3 BED35_21775 ENOG4107YZP Rhodanese domain protein BED35_21780 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BED35_21785 ENOG41063SB peptidase BED35_21790 ENOG4105PXI polysaccharide deacetylase BED35_21805 ENOG4105CPQ Dehydrogenase BED35_21810 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BED35_21815 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BED35_21820 ENOG4105XA0 heptosyltransferase ii BED35_21825 ENOG4105D16 lipopolysaccharide heptosyltransferase i BED35_21830 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BED35_21840 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BED35_21845 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BED35_21850 ENOG4105W0E 50S ribosomal protein L33 BED35_21855 ENOG4105KDC 50s ribosomal protein l28 BED35_21860 ENOG4105W5Q DNA repair protein (RadC BED35_21865 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BED35_21870 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BED35_21875 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BED35_21880 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BED35_21885 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BED35_21890 ENOG4105DSJ YicC domain protein BED35_21895 ENOG4105DFP Integrase BED35_21915 ENOG4105XB7 anti-repressor protein BED35_21995 ENOG4105BZU Histidine kinase BED35_22000 ENOG4105E39 Enoyl-CoA hydratase BED35_22005 ENOG4105D9N nucleoside BED35_22020 ENOG4105EN6 Membrane BED35_22035 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BED35_22040 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BED35_22045 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase BED35_22050 ENOG4105CB5 ATP-dependent DNA helicase recG BED35_22055 ENOG4105D6U Sodium Glutamate Symporter BED35_22060 ENOG4105C2W permease BED35_22065 ENOG4105JV1 AsmA family BED35_22080 ENOG4105HVQ Regulatory factor of maltose metabolism BED35_22085 ENOG4105SUU thioesterase domain BED35_22090 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BED35_22095 ENOG4107S2Z UPF0761 membrane protein BED35_22100 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 BED35_22110 ENOG4105C5F glutamine synthetase BED35_22120 ENOG4105CUX Signal transduction histidine kinase BED35_22125 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BED35_22130 ENOG4105D4P Coproporphyrinogen iii oxidase BED35_22135 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BED35_22140 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BED35_22145 ENOG4105C2M dna polymerase I BED35_22150 ENOG4108Z33 Thiol disulfide Interchange Protein BED35_22155 ENOG4105E27 serine threonine protein kinase BED35_22160 ENOG4105PC1 Conserved Protein BED35_22170 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b BED35_22205 ENOG4107EJG GntR family transcriptional regulator BED35_22215 ENOG4105ETE Transcriptional regulator (LacI family BED35_22220 ENOG4108RVA ribokinase BED35_22225 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BED35_22230 ENOG4105CNN ABC, transporter BED35_22240 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BED35_22250 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) BED35_22255 ENOG4105EV2 VWA domain protein interacting with AAA ATPase BED35_22265 ENOG4105CU9 asparagine synthetase A BED35_22270 ENOG4108VVK transcriptional Regulator, AsnC BED35_22275 ENOG4105QTB Flavodoxin BED35_22280 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BED35_22285 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BED35_22290 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation BED35_22295 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BED35_22300 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BED35_22305 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BED35_22310 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BED35_22315 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BED35_22320 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BED35_22325 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BED35_22330 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BED35_22335 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BED35_22340 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BED35_22345 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BED35_22350 ENOG4105C8U phosphate abc transporter BED35_22355 ENOG4105E2Z phosphate ABC transporter (Permease BED35_22375 ENOG4106PMH Extracellular solute-binding protein family 3 BED35_22385 ENOG4105DRP amino acid AbC transporter BED35_22390 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 BED35_22395 ENOG4105C7N Xanthine uracil vitamin C permease BED35_22405 ENOG4108ZXC Two component transcriptional regulator, luxr family BED35_22410 ENOG4105BZU Histidine kinase BED35_22415 ENOG4108YYH Nadph-dependent fmn reductase BED35_22420 ENOG4105C8Q Methyl-accepting chemotaxis BED35_22425 ENOG4108UMI ABC transporter, permease BED35_22440 ENOG4105RKW reductase (By BED35_22445 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BED35_22450 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BED35_22460 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BED35_22465 ENOG4105VG0 50S ribosomal protein l34