locus-tag	class	description
BED35_00120	COG1470	cell adhesion involved in biofilm formation
BED35_00120	COG1388	LysM domain
BED35_00125	COG1388	LysM domain
BED35_00125	COG1470	cell adhesion involved in biofilm formation
BED35_00265	COG3210	domain, Protein
BED35_00270	COG2831	hemolysin activation secretion protein
BED35_00490	COG3328	transposase activity
BED35_00500	COG4886	Leucine-rich repeat (LRR) protein
BED35_00500	COG4886	Leucine-rich repeat (LRR) protein
BED35_00535	COG2801	Transposase and inactivated derivatives
BED35_00630	COG0431	NADPH-dependent FMN reductase
BED35_00635	COG0640	Transcriptional regulator
BED35_00720	COG1192	Involved in chromosome partitioning
BED35_00725	COG1475	DNA binding
BED35_00730	COG3609	addiction module antidote protein, CC2985 family
BED35_00845	COG4792	protein secretion
BED35_00850	COG4791	protein targeting
BED35_00855	COG4794	Type iii secretion
BED35_00865	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BED35_00935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BED35_00940	COG0592	DNA-directed DNA polymerase activity
BED35_00945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BED35_00950	COG0187	DNA topoisomerase II activity
BED35_00955	COG0561	phosphatase activity
BED35_00960	COG2423	ornithine cyclodeaminase activity
BED35_00970	COG0823	Involved in the tonB-independent uptake of proteins
BED35_00975	COG5645	(Lipo)protein
BED35_01005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BED35_01015	COG3074	FtsZ-dependent cytokinesis
BED35_01020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BED35_01025	COG1575	Belongs to the MenA family. Type 1 subfamily
BED35_01030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BED35_01035	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BED35_01040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BED35_01045	COG1609	Transcriptional regulator
BED35_01050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BED35_01055	COG0254	rRNA binding
BED35_01060	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BED35_01065	COG0626	cystathionine gamma-synthase activity
BED35_01070	COG0527	aspartate kinase activity
BED35_01070	COG0460	homoserine dehydrogenase
BED35_01080	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BED35_01090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BED35_01095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BED35_01100	COG0165	Argininosuccinate lyase
BED35_01155	COG0678	peroxiredoxin activity
BED35_01155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED35_01165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED35_01170	COG1309	transcriptional regulator
BED35_01180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED35_01190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BED35_01230	COG1879	ABC-type sugar transport system periplasmic component
BED35_01235	COG1129	ABC transporter
BED35_01240	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_01245	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_01250	COG0583	DNA-binding transcription factor activity
BED35_01255	COG3085	chromosome segregation
BED35_01270	COG3978	acetolactate synthase activity
BED35_01275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BED35_01280	COG0129	dihydroxy-acid dehydratase activity
BED35_01300	COG0583	DNA-binding transcription factor activity
BED35_01305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BED35_01330	COG3121	Chaperone
BED35_01350	COG3121	Chaperone
BED35_01365	COG1609	Transcriptional regulator
BED35_01390	COG3328	transposase activity
BED35_01400	COG3210	domain, Protein
BED35_01430	COG3851	Histidine kinase
BED35_01435	COG2197	response regulator
BED35_01440	COG2194	sulfuric ester hydrolase activity
BED35_01445	COG1764	response to oxidative stress
BED35_01455	COG0747	negative chemotaxis
BED35_01460	COG0601	transmembrane transport
BED35_01465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED35_01470	COG0444	Belongs to the ABC transporter superfamily
BED35_01475	COG4608	Belongs to the ABC transporter superfamily
BED35_01480	COG2194	sulfuric ester hydrolase activity
BED35_01500	COG1192	Involved in chromosome partitioning
BED35_01505	COG1215	transferase activity, transferring glycosyl groups
BED35_01510	COG1215	transferase activity, transferring glycosyl groups
BED35_01515	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BED35_01520	COG0457	Tetratricopeptide repeat
BED35_01520	COG3118	belongs to the thioredoxin family
BED35_01530	COG2200	EAL domain
BED35_01530	COG2199	diguanylate cyclase activity
BED35_01535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED35_01550	COG1301	dicarboxylic acid transport
BED35_01555	COG0612	Peptidase, M16
BED35_01560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED35_01565	COG1942	4-Oxalocrotonate Tautomerase
BED35_01570	COG2200	EAL domain
BED35_01580	COG2134	cdp-diacylglycerol pyrophosphatase
BED35_01585	COG1295	ribonuclease BN
BED35_01595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED35_01600	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BED35_01610	COG0742	ribosomal rna small subunit methyltransferase
BED35_01625	COG0589	response to stress
BED35_01640	COG0306	phosphate transporter
BED35_01645	COG2081	HI0933 family
BED35_01690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BED35_01710	COG1301	dicarboxylic acid transport
BED35_01725	COG3799	methylaspartate ammonia-lyase activity
BED35_01730	COG4865	methylaspartate mutase activity
BED35_01750	COG1648	precorrin-2 dehydrogenase activity
BED35_01750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED35_01755	COG0583	DNA-binding transcription factor activity
BED35_01760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BED35_01760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BED35_01770	COG0561	phosphatase activity
BED35_01780	COG0583	DNA-binding transcription factor activity
BED35_01785	COG2814	Major facilitator Superfamily
BED35_01795	COG3718	enzyme involved in inositol metabolism
BED35_01805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED35_01815	COG0673	inositol 2-dehydrogenase activity
BED35_01820	COG1082	Xylose isomerase domain protein TIM barrel
BED35_01825	COG1247	-acetyltransferase
BED35_01830	COG1741	Belongs to the pirin family
BED35_01835	COG1609	Transcriptional regulator
BED35_01840	COG2610	gluconate transmembrane transporter activity
BED35_01845	COG3265	gluconokinase activity
BED35_01850	COG2095	MarC family integral membrane protein
BED35_01855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BED35_01875	COG3275	phosphorelay sensor kinase activity
BED35_01880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BED35_01885	COG1523	belongs to the glycosyl hydrolase 13 family
BED35_01895	COG0297	glycogen (starch) synthase activity
BED35_01900	COG0058	SHG alpha-glucan phosphorylase activity
BED35_01905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BED35_01920	COG1349	DNA-binding transcription factor activity
BED35_01925	COG0705	Rhomboid family
BED35_01940	COG2909	trisaccharide binding
BED35_01945	COG0058	SHG alpha-glucan phosphorylase activity
BED35_01950	COG1640	4-alpha-glucanotransferase
BED35_01955	COG0316	Belongs to the HesB IscA family
BED35_01955	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BED35_01965	COG0596	Alpha beta hydrolase
BED35_01985	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BED35_01990	COG1918	ferrous iron import across plasma membrane
BED35_01995	COG2183	response to ionizing radiation
BED35_02020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED35_02025	COG0745	RESPONSE REGULATOR receiver
BED35_02035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BED35_02045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BED35_02050	COG1011	Hydrolase
BED35_02060	COG0494	nUDIX hydrolase
BED35_02065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BED35_02090	COG4796	Type ii and iii secretion system protein
BED35_02095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BED35_02115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BED35_02125	COG0180	Tryptophanyl-tRNA synthetase
BED35_02130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED35_02130	COG1648	precorrin-2 dehydrogenase activity
BED35_02140	COG2146	nitrite reductase [NAD(P)H] activity
BED35_02145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BED35_02150	COG0402	S-adenosylhomocysteine deaminase activity
BED35_02155	COG0738	Major facilitator superfamily
BED35_02165	COG1486	melibiose metabolic process
BED35_02170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BED35_02175	COG0433	COG0433 Predicted ATPase
BED35_02200	COG1765	OsmC-like protein
BED35_02205	COG3954	Phosphoribulokinase
BED35_02210	COG3089	Belongs to the UPF0270 family
BED35_02215	COG0429	hydrolase of the alpha beta-hydrolase fold
BED35_02230	COG4521	taurine ABC transporter
BED35_02240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BED35_02245	COG2175	clavaminate synthase activity
BED35_02255	COG1216	Glycosyl transferase, family 2
BED35_02260	COG0488	(ABC) transporter
BED35_02265	COG2249	NAD(P)H dehydrogenase (quinone) activity
BED35_02275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BED35_02280	COG1047	Peptidyl-prolyl cis-trans
BED35_02285	COG2900	Belongs to the SlyX family
BED35_02290	COG0545	Peptidyl-prolyl cis-trans isomerase
BED35_02295	COG2964	Protein conserved in bacteria
BED35_02300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BED35_02305	COG2923	Belongs to the DsrF TusC family
BED35_02310	COG2168	tRNA wobble position uridine thiolation
BED35_02315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BED35_02320	COG0049	tRNA binding
BED35_02345	COG0051	transcription antitermination factor activity, RNA binding
BED35_02350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BED35_02355	COG0088	Forms part of the polypeptide exit tunnel
BED35_02360	COG0089	rRNA binding
BED35_02365	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BED35_02370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BED35_02375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BED35_02380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BED35_02385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BED35_02390	COG0255	Belongs to the universal ribosomal protein uL29 family
BED35_02395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BED35_02400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BED35_02405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BED35_02410	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BED35_02415	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BED35_02425	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BED35_02430	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BED35_02435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BED35_02440	COG1841	ribosomal large subunit assembly
BED35_02445	COG0200	Binds to the 23S rRNA
BED35_02450	COG0201	protein transport
BED35_02455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BED35_02465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BED35_02470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BED35_02475	COG0202	RNA polymerase activity
BED35_02480	COG0203	ribosomal protein L17
BED35_02490	COG0789	Transcriptional regulator
BED35_02495	COG3036	rescue of stalled ribosome
BED35_02505	COG1970	mechanosensitive ion channel activity
BED35_02510	COG0569	domain protein
BED35_02515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BED35_02515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BED35_02520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BED35_02525	COG0242	peptide deformylase activity
BED35_02530	COG0758	DNA mediated transformation
BED35_02540	COG0551	DNA topoisomerase type I activity
BED35_02545	COG0009	L-threonylcarbamoyladenylate synthase
BED35_02550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BED35_02555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BED35_02590	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BED35_02595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BED35_02600	COG2224	Isocitrate lyase
BED35_02605	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BED35_02610	COG1414	Transcriptional regulator
BED35_02635	COG0527	aspartate kinase activity
BED35_02640	COG0166	Belongs to the GPI family
BED35_02655	COG3833	ABC-type maltose transport systems, permease component
BED35_02665	COG2182	Extracellular solute-binding protein
BED35_02675	COG4580	involved in the transport of maltose and maltodextrins
BED35_02690	COG3161	chorismate lyase activity
BED35_02695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BED35_02700	COG2937	Belongs to the GPAT DAPAT family
BED35_02705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BED35_02710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BED35_02715	COG3237	CsbD-like
BED35_02720	COG0735	belongs to the Fur family
BED35_02725	COG2755	lipolytic protein G-D-S-L family
BED35_02725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BED35_02730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED35_02750	COG0305	Participates in initiation and elongation during chromosome replication
BED35_02760	COG1448	Aminotransferase
BED35_02765	COG2315	Protein conserved in bacteria
BED35_02770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BED35_02780	COG3550	peptidyl-serine autophosphorylation
BED35_02795	COG2252	PERMEase
BED35_02800	COG0025	NhaP-type Na H and K H
BED35_02805	COG0583	DNA-binding transcription factor activity
BED35_02810	COG1380	Effector of murein hydrolase LrgA
BED35_02820	COG1126	abc transporter atp-binding protein
BED35_02825	COG0765	amino acid transport
BED35_02830	COG4597	amino acid ABC transporter
BED35_02835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED35_02850	COG1560	Kdo2-lipid A biosynthetic process
BED35_02855	COG0471	metal ion transport
BED35_02860	COG1278	Cold shock
BED35_02865	COG1278	Cold shock
BED35_02870	COG3133	Outer membrane lipoprotein
BED35_02880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BED35_02885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED35_02890	COG2264	protein methyltransferase activity
BED35_02895	COG4145	pantothenate transmembrane transporter activity
BED35_02900	COG3924	membrane
BED35_02905	COG0439	Biotin carboxylase
BED35_02910	COG0511	ligase activity, forming carbon-carbon bonds
BED35_02915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BED35_02920	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BED35_02930	COG0604	alcohol dehydrogenase
BED35_02935	COG2200	EAL domain
BED35_02935	COG2199	diguanylate cyclase activity
BED35_02940	COG1077	Cell shape determining protein MreB Mrl
BED35_02945	COG1792	Involved in formation and maintenance of cell shape
BED35_02950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BED35_02960	COG1530	ribonuclease E activity
BED35_02965	COG3164	Protein of unknown function
BED35_02970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED35_02975	COG0312	modulator of DNA gyrase
BED35_03030	COG0583	DNA-binding transcription factor activity
BED35_03040	COG1566	PFAM secretion protein HlyD family protein
BED35_03045	COG1289	transmembrane transporter activity
BED35_03060	COG2732	(Barnase) inhibitor
BED35_03065	COG3028	Belongs to the UPF0307 family
BED35_03070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED35_03245	COG0312	modulator of DNA gyrase
BED35_03255	COG3783	Cytochrome b(562)
BED35_03260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED35_03290	COG3964	amidohydrolase
BED35_03310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_03310	COG3711	transcriptional antiterminator
BED35_03315	COG3093	addiction module antidote protein HigA
BED35_03340	COG0366	Alpha amylase catalytic
BED35_03360	COG2308	Evidence 4 Homologs of previously reported genes of
BED35_03370	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BED35_03375	COG0540	Belongs to the ATCase OTCase family
BED35_03380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_03385	COG1660	Displays ATPase and GTPase activities
BED35_03390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_03400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BED35_03405	COG1137	ATPase activity
BED35_03410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BED35_03415	COG3117	lipopolysaccharide transmembrane transporter activity
BED35_03420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BED35_03425	COG0517	IMP dehydrogenase activity
BED35_03425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BED35_03435	COG1127	ABC transporter
BED35_03440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BED35_03445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BED35_03450	COG2854	intermembrane phospholipid transfer
BED35_03455	COG3113	response to antibiotic
BED35_03460	COG5007	Belongs to the BolA IbaG family
BED35_03465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BED35_03470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED35_03475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED35_03480	COG3105	Protein conserved in bacteria
BED35_03485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BED35_03490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BED35_03495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BED35_03500	COG0625	glutathione transferase activity
BED35_03505	COG2969	positive regulation of protein catabolic process
BED35_03520	COG0493	'glutamate synthase
BED35_03525	COG0069	glutamate synthase activity
BED35_03525	COG0070	glutamate synthase
BED35_03525	COG0067	glutamate synthase
BED35_03530	COG1242	4 iron, 4 sulfur cluster binding
BED35_03535	COG0784	Response regulator, receiver
BED35_03535	COG2198	Histidine kinase
BED35_03535	COG5002	protein histidine kinase activity
BED35_03540	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BED35_03545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BED35_03550	COG2823	Periplasmic or secreted lipoprotein
BED35_03555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BED35_03560	COG0792	nuclease activity
BED35_03570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BED35_03625	COG3121	Chaperone
BED35_03630	COG3188	usher protein
BED35_03645	COG0667	Aldo Keto reductase
BED35_03650	COG1064	alcohol dehydrogenase
BED35_03655	COG1741	Belongs to the pirin family
BED35_03660	COG0583	DNA-binding transcription factor activity
BED35_03665	COG0435	Glutathione S-transferase
BED35_03670	COG2259	Doxx family
BED35_03680	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BED35_03685	COG4575	ribosome binding
BED35_03700	COG0586	Pfam SNARE associated Golgi protein
BED35_03715	COG2271	Major facilitator Superfamily
BED35_03720	COG1904	glucuronate isomerase
BED35_03725	COG0246	Mannitol dehydrogenase
BED35_03730	COG2721	sulfolactate sulfo-lyase activity
BED35_03740	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BED35_03745	COG0861	Integral membrane protein TerC family
BED35_03755	COG0673	inositol 2-dehydrogenase activity
BED35_03760	COG1451	nucleotide metabolic process
BED35_03780	COG2813	Specifically methylates the guanine in position
BED35_03790	COG1902	pentaerythritol trinitrate reductase activity
BED35_03790	COG0446	pyridine nucleotide-disulphide oxidoreductase
BED35_03800	COG3247	response to pH
BED35_03810	COG0076	glutamate decarboxylase activity
BED35_03815	COG0531	amino acid
BED35_03830	COG3328	transposase activity
BED35_03835	COG1263	PTS System
BED35_03835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_03840	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BED35_03850	COG1472	Belongs to the glycosyl hydrolase 3 family
BED35_03860	COG3876	Protein conserved in bacteria
BED35_03875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BED35_03880	COG0358	DNA primase activity
BED35_03890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BED35_03895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BED35_03900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BED35_03905	COG1968	undecaprenyl-diphosphatase activity
BED35_03910	COG0617	tRNA 3'-terminal CCA addition
BED35_03915	COG4991	sh3 domain protein
BED35_03920	COG3025	triphosphatase activity
BED35_03925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BED35_03930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BED35_03930	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BED35_03935	COG0531	amino acid
BED35_03945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BED35_03950	COG3384	dioxygenase
BED35_03955	COG0754	glutathionylspermidine amidase activity
BED35_03960	COG5463	Belongs to the UPF0441 family
BED35_03970	COG1538	Outer membrane efflux protein
BED35_03975	COG0494	nUDIX hydrolase
BED35_03980	COG3151	Protein conserved in bacteria
BED35_03985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BED35_03990	COG3150	esterase
BED35_03995	COG0187	DNA topoisomerase II activity
BED35_04005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED35_04010	COG2249	NAD(P)H dehydrogenase (quinone) activity
BED35_04015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BED35_04020	COG0204	Acyl-transferase
BED35_04025	COG2132	Multicopper oxidase
BED35_04035	COG0656	L-ascorbic acid biosynthetic process
BED35_04040	COG1979	alcohol dehydrogenase
BED35_04045	COG2207	Transcriptional regulator
BED35_04050	COG0586	Pfam SNARE associated Golgi protein
BED35_04055	COG0626	cystathionine gamma-synthase activity
BED35_04060	COG0811	peptide transport
BED35_04065	COG0848	biopolymer transport protein
BED35_04115	COG4964	Belongs to the GSP D family
BED35_04140	COG3145	DNA-N1-methyladenine dioxygenase activity
BED35_04145	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED35_04155	COG2135	peptidase activity
BED35_04175	COG2963	transposase activity
BED35_04195	COG1136	(ABC) transporter
BED35_04195	COG0577	efflux transmembrane transporter activity
BED35_04210	COG2801	Transposase and inactivated derivatives
BED35_04230	COG1120	ATPase activity
BED35_04235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED35_04240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED35_04245	COG4592	Periplasmic binding protein
BED35_04255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED35_04260	COG0840	transmembrane signaling receptor activity
BED35_04275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED35_04305	COG2204	response regulator
BED35_04310	COG1677	Flagellar hook-basal body complex protein FliE
BED35_04355	COG1815	bacterial-type flagellum-dependent cell motility
BED35_04360	COG1558	bacterial-type flagellum-dependent cell motility
BED35_04365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BED35_04370	COG1749	Flagellar hook protein flgE
BED35_04380	COG4786	Flagellar basal body rod
BED35_04390	COG1706	bacterial-type flagellum-dependent cell motility
BED35_04425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BED35_04435	COG1516	flagellar protein fliS
BED35_04455	COG1191	sigma factor activity
BED35_04460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BED35_04470	COG3133	Outer membrane lipoprotein
BED35_04475	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BED35_04480	COG0437	4 iron, 4 sulfur cluster binding
BED35_04485	COG5557	Pfam Polysulphide reductase, NrfD
BED35_04490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BED35_04495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BED35_04500	COG1773	rubredoxin
BED35_04505	COG0375	protein maturation
BED35_04510	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BED35_04515	COG0298	carbon dioxide binding
BED35_04520	COG0409	Hydrogenase expression formation protein
BED35_04525	COG0309	Hydrogenase expression formation protein (HypE)
BED35_04530	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BED35_04540	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BED35_04555	COG5001	Diguanylate cyclase
BED35_04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_04575	COG0477	Major facilitator Superfamily
BED35_04590	COG1283	sodium-dependent phosphate transmembrane transporter activity
BED35_04600	COG1609	Transcriptional regulator
BED35_04610	COG0477	Major facilitator Superfamily
BED35_04620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED35_04640	COG4607	ABC-type enterochelin transport system periplasmic component
BED35_04650	COG4605	iron ion homeostasis
BED35_04660	COG0024	Methionine aminopeptidase
BED35_04685	COG1289	transmembrane transporter activity
BED35_04695	COG1982	Orn Lys Arg decarboxylase major
BED35_04700	COG0531	amino acid
BED35_04740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED35_04755	COG1982	Orn Lys Arg decarboxylase major
BED35_04765	COG0741	lytic transglycosylase activity
BED35_04770	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BED35_04775	COG1194	a g-specific adenine glycosylase
BED35_04780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BED35_04785	COG3171	Protein conserved in bacteria
BED35_04790	COG2066	Belongs to the glutaminase family
BED35_04800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BED35_04805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BED35_04810	COG1872	DUF167
BED35_04815	COG0762	integral membrane protein
BED35_04820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BED35_04825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BED35_04830	COG2805	Type II/IV secretion system protein
BED35_04840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED35_04845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BED35_04850	COG1678	Uncharacterized ACR, COG1678
BED35_04855	COG0189	ligase activity
BED35_04860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BED35_04865	COG2356	endonuclease I
BED35_04870	COG3091	SprT-like family
BED35_04875	COG0640	Transcriptional regulator
BED35_04880	COG3328	transposase activity
BED35_04895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BED35_04900	COG1166	arginine decarboxylase activity
BED35_04910	COG0501	Belongs to the peptidase M48B family
BED35_04915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BED35_04920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BED35_04925	COG0126	phosphoglycerate kinase activity
BED35_04930	COG0191	fructose-bisphosphate aldolase activity
BED35_04950	COG1279	arginine transmembrane transporter activity
BED35_04960	COG0583	DNA-binding transcription factor activity
BED35_04965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BED35_04970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED35_05005	COG0602	queuosine metabolic process
BED35_05025	COG0720	synthase
BED35_05030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BED35_05035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BED35_05040	COG0175	sulfate reduction
BED35_05055	COG2234	aminopeptidase activity
BED35_05060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BED35_05060	COG1648	precorrin-2 dehydrogenase activity
BED35_05065	COG0175	sulfate reduction
BED35_05070	COG2895	sulfate adenylyltransferase (ATP) activity
BED35_05075	COG0529	Catalyzes the synthesis of activated sulfate
BED35_05085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BED35_05095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BED35_05100	COG0585	pseudouridine synthase activity
BED35_05105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BED35_05110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BED35_05115	COG4942	peptidase
BED35_05115	COG1388	LysM domain
BED35_05120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BED35_05125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BED35_05150	COG3188	usher protein
BED35_05155	COG3121	Chaperone
BED35_05165	COG3539	Fimbrial protein
BED35_05170	COG3539	Fimbrial protein
BED35_05200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_05210	COG1538	Outer membrane efflux protein
BED35_05230	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_05235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED35_05240	COG1858	cytochrome C peroxidase
BED35_05250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BED35_05255	COG0640	Transcriptional regulator
BED35_05310	COG0410	ABC transporter
BED35_05315	COG1137	ATPase activity
BED35_05320	COG4177	L-phenylalanine transmembrane transporter activity
BED35_05325	COG0559	Belongs to the binding-protein-dependent transport system permease family
BED35_05335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BED35_05335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BED35_05340	COG0243	molybdopterin cofactor binding
BED35_05345	COG0437	4 iron, 4 sulfur cluster binding
BED35_05350	COG3302	dmso reductase anchor subunit
BED35_05355	COG3381	protein complex oligomerization
BED35_05375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BED35_05380	COG2137	regulation of response to DNA damage stimulus
BED35_05385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BED35_05390	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BED35_05410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED35_05420	COG2918	glutathione biosynthetic process
BED35_05425	COG1854	S-ribosylhomocysteine lyase activity
BED35_05430	COG4536	flavin adenine dinucleotide binding
BED35_05445	COG4137	Cytochrome C assembly protein
BED35_05450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BED35_05455	COG0228	four-way junction DNA binding
BED35_05460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BED35_05465	COG0336	Belongs to the RNA methyltransferase TrmD family
BED35_05470	COG0335	large ribosomal subunit rRNA binding
BED35_05480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BED35_05485	COG3279	Response regulator of the LytR AlgR family
BED35_05490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BED35_05495	COG0287	Prephenate dehydrogenase
BED35_05495	COG1605	Chorismate mutase
BED35_05500	COG0077	Prephenate dehydratase
BED35_05500	COG1605	Chorismate mutase
BED35_05510	COG0542	response to heat
BED35_05520	COG0564	pseudouridine synthase activity
BED35_05525	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED35_05535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BED35_05540	COG3328	transposase activity
BED35_05545	COG3547	Transposase (IS116 IS110 IS902 family)
BED35_05575	COG5544	Lipoprotein
BED35_05580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BED35_05585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED35_05585	COG0045	succinate-CoA ligase (ADP-forming) activity
BED35_05585	COG1042	CoA-binding domain protein
BED35_05595	COG3118	belongs to the thioredoxin family
BED35_05600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED35_05605	COG2814	Major facilitator Superfamily
BED35_05610	COG1566	PFAM secretion protein HlyD family protein
BED35_05615	COG1538	Outer membrane efflux protein
BED35_05620	COG1846	Transcriptional regulator
BED35_05630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BED35_05635	COG2814	Major facilitator Superfamily
BED35_05670	COG0765	amino acid transport
BED35_05675	COG0765	amino acid transport
BED35_05700	COG0436	Aminotransferase
BED35_05705	COG0582	viral genome integration into host DNA
BED35_05760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED35_05840	COG1484	DNA-dependent DNA replication
BED35_05940	COG5410	chromosome segregation
BED35_06075	COG0235	Class ii aldolase
BED35_06080	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
BED35_06085	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BED35_06090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BED35_06095	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BED35_06115	COG1960	acyl-CoA dehydrogenase activity
BED35_06125	COG0121	glutamine amidotransferase
BED35_06130	COG3034	peptidoglycan biosynthetic process
BED35_06135	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED35_06140	COG1805	sodium ion transport
BED35_06145	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED35_06150	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BED35_06160	COG2871	sodium ion transport
BED35_06165	COG1477	protein flavinylation
BED35_06170	COG2991	Protein conserved in bacteria
BED35_06180	COG1181	Belongs to the D-alanine--D-alanine ligase family
BED35_06185	COG2964	Protein conserved in bacteria
BED35_06200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BED35_06205	COG2195	Cleaves the N-terminal amino acid of tripeptides
BED35_06210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BED35_06230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BED35_06235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BED35_06240	COG2188	Transcriptional regulator
BED35_06260	COG3459	Glycosyltransferase 36 associated
BED35_06275	COG2226	methyltransferase
BED35_06300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BED35_06305	COG3123	guanosine phosphorylase activity
BED35_06310	COG2974	May be involved in recombination
BED35_06315	COG1940	carbohydrate kinase activity
BED35_06320	COG0419	ATPase involved in DNA repair
BED35_06325	COG0420	3'-5' exonuclease activity
BED35_06330	COG0745	RESPONSE REGULATOR receiver
BED35_06335	COG5002	protein histidine kinase activity
BED35_06345	COG1114	Component of the transport system for branched-chain amino acids
BED35_06355	COG0366	Alpha amylase catalytic
BED35_06375	COG0450	alkyl hydroperoxide reductase
BED35_06380	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BED35_06385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BED35_06395	COG0343	queuine tRNA-ribosyltransferase activity
BED35_06400	COG1862	Preprotein translocase
BED35_06405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BED35_06410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BED35_06425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BED35_06430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BED35_06430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BED35_06435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BED35_06440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BED35_06445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BED35_06450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BED35_06460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BED35_06465	COG0142	geranyltranstransferase activity
BED35_06475	COG0301	tRNA thio-modification
BED35_06475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BED35_06480	COG0693	protein deglycase activity
BED35_06485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BED35_06490	COG1666	GTP binding
BED35_06495	COG2814	Major facilitator Superfamily
BED35_06500	COG0109	protoheme IX farnesyltransferase activity
BED35_06505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BED35_06510	COG1845	cytochrome c oxidase, subunit III
BED35_06515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BED35_06520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BED35_06530	COG2223	nitrite transmembrane transporter activity
BED35_06535	COG3056	Lipoprotein
BED35_06540	COG0271	Belongs to the BolA IbaG family
BED35_06550	COG0544	peptidyl-prolyl cis-trans isomerase activity
BED35_06555	COG0740	serine-type endopeptidase activity
BED35_06560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BED35_06565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BED35_06570	COG0776	regulation of translation
BED35_06575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED35_06580	COG1555	photosystem II stabilization
BED35_06585	COG0824	Thioesterase
BED35_06590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BED35_06595	COG4533	DNA binding
BED35_06600	COG0561	phosphatase activity
BED35_06610	COG1522	sequence-specific DNA binding
BED35_06615	COG1132	(ABC) transporter
BED35_06620	COG1132	(ABC) transporter
BED35_06625	COG0347	Belongs to the P(II) protein family
BED35_06630	COG0004	ammonium transporteR
BED35_06635	COG1946	Acyl-CoA thioesterase
BED35_06640	COG3126	Type III secretion system lipoprotein chaperone (YscW)
BED35_06645	COG3695	enzyme binding
BED35_06675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED35_06680	COG0803	Belongs to the bacterial solute-binding protein 9 family
BED35_06685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BED35_06690	COG0254	rRNA binding
BED35_06705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BED35_06710	COG3457	Alanine racemase
BED35_06720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED35_06725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_06730	COG1309	transcriptional regulator
BED35_06735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BED35_06755	COG2832	Protein of unknown function (DUF454)
BED35_06760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BED35_06770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BED35_06775	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BED35_06780	COG0326	Molecular chaperone. Has ATPase activity
BED35_06785	COG0563	adenylate kinase activity
BED35_06790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BED35_06795	COG2244	polysaccharide biosynthetic process
BED35_06800	COG1216	Glycosyl transferase, family 2
BED35_06800	COG1442	glycosyl transferase family 8
BED35_06805	COG1215	transferase activity, transferring glycosyl groups
BED35_06810	COG0438	transferase activity, transferring glycosyl groups
BED35_06815	COG0438	transferase activity, transferring glycosyl groups
BED35_06820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED35_06840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED35_06845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BED35_06845	COG4651	solute:proton antiporter activity
BED35_06850	COG2223	nitrite transmembrane transporter activity
BED35_06865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BED35_06870	COG3735	TraB family
BED35_06875	COG2217	Heavy metal translocating P-type atpase
BED35_06880	COG0789	Transcriptional regulator
BED35_06885	COG1585	Membrane protein implicated in regulation of membrane protease activity
BED35_06890	COG0330	HflC and HflK could
BED35_06895	COG3118	belongs to the thioredoxin family
BED35_06900	COG0300	oxidoreductase activity
BED35_06905	COG2755	lipolytic protein G-D-S-L family
BED35_06910	COG4181	ATPase activity
BED35_06915	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BED35_06920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BED35_06925	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BED35_06930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED35_06935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BED35_06940	COG0215	cysteine-tRNA ligase activity
BED35_06945	COG2501	S4 domain
BED35_06950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BED35_06960	COG0582	viral genome integration into host DNA
BED35_07010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED35_07075	COG1484	DNA-dependent DNA replication
BED35_07235	COG4386	tail sheath protein
BED35_07300	COG0582	viral genome integration into host DNA
BED35_07425	COG0305	Participates in initiation and elongation during chromosome replication
BED35_07475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED35_07515	COG3772	lysozyme
BED35_07680	COG0582	viral genome integration into host DNA
BED35_07685	COG0582	viral genome integration into host DNA
BED35_07690	COG0582	viral genome integration into host DNA
BED35_07705	COG3177	Filamentation induced by cAMP protein fic
BED35_07790	COG2850	peptidyl-arginine hydroxylation
BED35_07805	COG5265	(ABC) transporter
BED35_07820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED35_07835	COG1278	Cold shock
BED35_07840	COG1278	Cold shock
BED35_07845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BED35_07850	COG3706	GGDEF domain
BED35_07855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED35_07860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BED35_07865	COG0321	lipoyl(octanoyl) transferase activity
BED35_07870	COG2921	Belongs to the UPF0250 family
BED35_07875	COG1686	Belongs to the peptidase S11 family
BED35_07880	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BED35_07885	COG0772	Belongs to the SEDS family
BED35_07890	COG0768	penicillin binding
BED35_07900	COG0799	negative regulation of ribosome biogenesis
BED35_07905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BED35_07910	COG1466	dna polymerase III delta subunit
BED35_07915	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BED35_07920	COG0495	leucyl-tRNA aminoacylation
BED35_07925	COG2888	peptidyl-tyrosine sulfation
BED35_07930	COG1126	abc transporter atp-binding protein
BED35_07935	COG0765	amino acid transport
BED35_07940	COG0765	amino acid transport
BED35_07955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BED35_07960	COG4535	Mg2 and Co2 transporter CorC
BED35_07970	COG1702	phosphate starvation-inducible protein PhoH
BED35_07975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BED35_07980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED35_08015	COG0367	asparagine synthase
BED35_08020	COG0647	UMP catabolic process
BED35_08025	COG1846	Transcriptional regulator
BED35_08025	COG1940	carbohydrate kinase activity
BED35_08030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BED35_08035	COG0363	glucosamine-6-phosphate deaminase activity
BED35_08045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BED35_08065	COG0735	belongs to the Fur family
BED35_08075	COG0840	transmembrane signaling receptor activity
BED35_08085	COG0596	Alpha beta hydrolase
BED35_08090	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BED35_08095	COG0033	Phosphoglucomutase
BED35_08110	COG0745	RESPONSE REGULATOR receiver
BED35_08115	COG2205	protein histidine kinase activity
BED35_08120	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BED35_08125	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BED35_08130	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BED35_08150	COG2994	toxin metabolic process
BED35_08160	COG3272	Protein of unknown function (DUF1722)
BED35_08170	COG5212	phosphodiesterase
BED35_08175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BED35_08180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BED35_08185	COG1984	allophanate hydrolase subunit 2
BED35_08190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BED35_08205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BED35_08215	COG2009	succinate dehydrogenase
BED35_08220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BED35_08225	COG1053	succinate dehydrogenase
BED35_08235	COG0567	Dehydrogenase, E1 component
BED35_08240	COG0508	dehydrogenase complex catalyzes the overall conversion of
BED35_08245	COG0045	succinate-CoA ligase (ADP-forming) activity
BED35_08250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BED35_08255	COG0737	Belongs to the 5'-nucleotidase family
BED35_08260	COG1271	oxidase subunit
BED35_08265	COG1294	oxidase, subunit
BED35_08270	COG4890	Cyd operon protein YbgT
BED35_08275	COG3790	cyd operon protein YbgE
BED35_08280	COG0824	Thioesterase
BED35_08285	COG0811	peptide transport
BED35_08290	COG0848	biopolymer transport protein
BED35_08295	COG3064	Membrane
BED35_08295	COG3064	Membrane
BED35_08300	COG0823	Involved in the tonB-independent uptake of proteins
BED35_08305	COG2885	chlorophyll binding
BED35_08310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BED35_08335	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BED35_08345	COG1230	cation diffusion facilitator family transporter
BED35_08350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BED35_08355	COG0588	phosphoglycerate mutase activity
BED35_08380	COG2017	converts alpha-aldose to the beta-anomer
BED35_08385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BED35_08390	COG1085	galactose-1-phosphate uridylyltransferase
BED35_08395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BED35_08405	COG1119	ATPase activity
BED35_08410	COG3585	molybdate ion transport
BED35_08410	COG2005	Transcriptional regulator
BED35_08420	COG0725	ABC transporter, periplasmic molybdate-binding protein
BED35_08425	COG4149	molybdate abc transporter
BED35_08435	COG0561	phosphatase activity
BED35_08440	COG2706	6-phosphogluconolactonase activity
BED35_08450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BED35_08455	COG0156	8-amino-7-oxononanoate synthase activity
BED35_08460	COG2226	methyltransferase
BED35_08465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BED35_08475	COG0556	nucleotide-excision repair
BED35_08480	COG4628	conserved protein (DUF2132)
BED35_08485	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BED35_08490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BED35_08495	COG0315	cyclic pyranopterin monophosphate synthase activity
BED35_08500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BED35_08505	COG0314	molybdopterin synthase activity
BED35_08510	COG0670	Belongs to the BI1 family
BED35_08515	COG0842	Transport permease protein
BED35_08520	COG0842	Transport permease protein
BED35_08525	COG1131	(ABC) transporter
BED35_08530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_08535	COG1309	transcriptional regulator
BED35_08540	COG0513	Belongs to the DEAD box helicase family
BED35_08545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BED35_08555	COG2239	Acts as a magnesium transporter
BED35_08560	COG1686	Belongs to the peptidase S11 family
BED35_08565	COG0277	FAD linked oxidase domain protein
BED35_08575	COG1403	HNH endonuclease
BED35_08585	COG2261	transglycosylase associated protein
BED35_08595	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BED35_08610	COG4807	Protein conserved in bacteria
BED35_08630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BED35_08640	COG2897	thiosulfate sulfurtransferase activity
BED35_08655	COG1732	Glycine betaine
BED35_08665	COG1125	glycine betaine transport
BED35_08670	COG1174	glycine betaine transport
BED35_08685	COG0583	DNA-binding transcription factor activity
BED35_08695	COG0697	spore germination
BED35_08715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BED35_08720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BED35_08740	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BED35_08750	COG1126	abc transporter atp-binding protein
BED35_08755	COG0765	amino acid transport
BED35_08760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED35_08765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BED35_08770	COG0783	Belongs to the Dps family
BED35_08775	COG4106	trans-aconitate 2-methyltransferase activity
BED35_08790	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BED35_08810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BED35_08830	COG0488	(ABC) transporter
BED35_08840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BED35_08845	COG0303	'Molybdopterin
BED35_08860	COG0577	efflux transmembrane transporter activity
BED35_08860	COG1136	(ABC) transporter
BED35_08890	COG0583	DNA-binding transcription factor activity
BED35_08895	COG0477	Major facilitator Superfamily
BED35_08900	COG0302	gtp cyclohydrolase
BED35_08905	COG2311	Membrane
BED35_08930	COG3604	Transcriptional regulator
BED35_08940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED35_08945	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BED35_08955	COG3260	NADH ubiquinone oxidoreductase 20
BED35_08960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED35_08965	COG3261	NADH dehydrogenase
BED35_08965	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BED35_08970	COG0651	ATP synthesis coupled electron transport
BED35_08975	COG4237	Hydrogenase 4 membrane
BED35_08980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BED35_08985	COG0650	Formate hydrogenlyase subunit 4
BED35_08990	COG0651	ATP synthesis coupled electron transport
BED35_08995	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED35_09000	COG0375	protein maturation
BED35_09005	COG0298	carbon dioxide binding
BED35_09010	COG2949	membrane
BED35_09015	COG0281	malic enzyme
BED35_09030	COG1346	cytolysis
BED35_09035	COG1380	Effector of murein hydrolase LrgA
BED35_09040	COG2814	Major facilitator Superfamily
BED35_09060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BED35_09060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BED35_09065	COG0489	protein tyrosine kinase activity
BED35_09070	COG0572	uridine kinase
BED35_09080	COG2982	Protein involved in outer membrane biogenesis
BED35_09085	COG3069	C4-dicarboxylate transmembrane transporter activity
BED35_09090	COG1253	flavin adenine dinucleotide binding
BED35_09130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED35_09150	COG3328	transposase activity
BED35_09175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BED35_09180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BED35_09185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BED35_09190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BED35_09190	COG0140	phosphoribosyl-ATP diphosphatase activity
BED35_09195	COG0107	imidazoleglycerol-phosphate synthase activity
BED35_09200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BED35_09205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BED35_09210	COG0131	Imidazoleglycerol-phosphate dehydratase
BED35_09210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BED35_09215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED35_09225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BED35_09230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED35_09235	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_09240	COG1129	ABC transporter
BED35_09245	COG0371	Dehydrogenase
BED35_09255	COG0531	amino acid
BED35_09260	COG2925	Exonuclease
BED35_09265	COG1022	Amp-dependent synthetase and ligase
BED35_09265	COG3320	Male sterility
BED35_09270	COG1289	transmembrane transporter activity
BED35_09275	COG2926	Belongs to the UPF0265 family
BED35_09285	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_09295	COG1879	ABC-type sugar transport system periplasmic component
BED35_09305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BED35_09315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BED35_09325	COG4810	utilization protein
BED35_09335	COG4656	Part of a membrane complex involved in electron transport
BED35_09345	COG1012	belongs to the aldehyde dehydrogenase family
BED35_09375	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BED35_09410	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BED35_09440	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BED35_09445	COG2241	protein methyltransferase activity
BED35_09455	COG2875	Belongs to the precorrin methyltransferase family
BED35_09505	COG1492	cobalamin metabolic process
BED35_09525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BED35_09570	COG3501	Rhs element vgr protein
BED35_09595	COG0137	argininosuccinate synthase activity
BED35_09600	COG0534	Mate efflux family protein
BED35_09610	COG0352	thiamine-phosphate diphosphorylase activity
BED35_09615	COG0561	phosphatase activity
BED35_09620	COG1349	DNA-binding transcription factor activity
BED35_09630	COG0784	Response regulator, receiver
BED35_09630	COG0835	chemotaxis
BED35_09660	COG3842	ATPase activity
BED35_09670	COG1840	ABC-type Fe3 transport system, periplasmic component
BED35_09675	COG2271	Major facilitator Superfamily
BED35_09690	COG4565	transcriptional regulatory protein
BED35_09695	COG3290	protein histidine kinase activity
BED35_09710	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BED35_09715	COG3052	prosthetic group binding
BED35_09720	COG2301	Belongs to the HpcH HpaI aldolase family
BED35_09725	COG3051	citrate lyase alpha subunit
BED35_09730	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BED35_09730	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
BED35_09740	COG0471	metal ion transport
BED35_09755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BED35_09775	COG2814	Major facilitator Superfamily
BED35_09780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_09780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_09785	COG3122	Protein conserved in bacteria
BED35_09805	COG3121	Chaperone
BED35_09845	COG3228	Belongs to the MtfA family
BED35_09855	COG1070	Carbohydrate kinase
BED35_09880	COG3121	Chaperone
BED35_09890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BED35_09920	COG3321	synthase
BED35_09920	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_09920	COG0604	alcohol dehydrogenase
BED35_09925	COG3328	transposase activity
BED35_09930	COG3250	beta-galactosidase activity
BED35_09935	COG1609	Transcriptional regulator
BED35_09940	COG1278	Cold shock
BED35_09950	COG0840	transmembrane signaling receptor activity
BED35_09965	COG1285	pathogenesis
BED35_09975	COG2130	NADP-dependent
BED35_09980	COG0589	response to stress
BED35_10000	COG1360	Flagellar Motor Protein
BED35_10005	COG0643	Histidine kinase
BED35_10005	COG2198	Histidine kinase
BED35_10010	COG0835	chemotaxis
BED35_10015	COG0840	transmembrane signaling receptor activity
BED35_10020	COG0840	transmembrane signaling receptor activity
BED35_10025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BED35_10035	COG0745	RESPONSE REGULATOR receiver
BED35_10040	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BED35_10050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED35_10055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BED35_10070	COG3418	PFAM FlgN family protein
BED35_10075	COG2747	anti-sigma28 factor FlgM
BED35_10085	COG1815	bacterial-type flagellum-dependent cell motility
BED35_10090	COG1558	bacterial-type flagellum-dependent cell motility
BED35_10095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BED35_10100	COG1749	Flagellar hook protein flgE
BED35_10110	COG4786	Flagellar basal body rod
BED35_10130	COG1256	bacterial-type flagellum assembly
BED35_10150	COG1338	Plays a role in the flagellum-specific transport system
BED35_10170	COG1580	Controls the rotational direction of flagella during chemotaxis
BED35_10180	COG2882	bacterial-type flagellum organization
BED35_10190	COG1317	bacterial-type flagellum organization
BED35_10195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BED35_10205	COG1677	Flagellar hook-basal body complex protein FliE
BED35_10210	COG0582	viral genome integration into host DNA
BED35_10230	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BED35_10235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BED35_10275	COG1191	sigma factor activity
BED35_10285	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BED35_10315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BED35_10315	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BED35_10315	COG0506	proline dehydrogenase activity
BED35_10335	COG3157	Type VI secretion system effector, Hcp
BED35_10355	COG0655	NAD(P)H dehydrogenase (quinone) activity
BED35_10365	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BED35_10380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BED35_10385	COG0778	Nitroreductase
BED35_10390	COG2267	carboxylic ester hydrolase activity
BED35_10400	COG1335	isochorismatase
BED35_10410	COG1309	transcriptional regulator
BED35_10415	COG1113	amino acid transport
BED35_10425	COG0582	viral genome integration into host DNA
BED35_10430	COG2963	transposase activity
BED35_10455	COG0366	Alpha amylase catalytic
BED35_10465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BED35_10600	COG3772	lysozyme
BED35_10605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BED35_10610	COG2979	Protein of unknown function (DUF533)
BED35_10625	COG0012	GTP binding
BED35_10635	COG0193	aminoacyl-tRNA hydrolase activity
BED35_10650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BED35_10660	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BED35_10665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BED35_10670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BED35_10675	COG2890	protein-(glutamine-N5) methyltransferase activity
BED35_10680	COG3094	Invasion gene expression up-regulator, SirB
BED35_10685	COG2912	Transglutaminase-like superfamily
BED35_10690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BED35_10695	COG0659	secondary active sulfate transmembrane transporter activity
BED35_10700	COG3706	GGDEF domain
BED35_10725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BED35_10730	COG3381	protein complex oligomerization
BED35_10740	COG0477	Major facilitator Superfamily
BED35_10755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED35_10765	COG0673	inositol 2-dehydrogenase activity
BED35_10770	COG0728	peptidoglycan biosynthetic process
BED35_10775	COG0387	Pfam Sodium calcium exchanger
BED35_10785	COG2814	Major facilitator Superfamily
BED35_10800	COG3850	Histidine kinase
BED35_10805	COG1294	oxidase, subunit
BED35_10810	COG1271	oxidase subunit
BED35_10815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED35_10820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BED35_10825	COG3138	arginine N-succinyltransferase
BED35_10835	COG3724	N-succinylarginine dihydrolase activity
BED35_10840	COG2988	succinylglutamate desuccinylase activity
BED35_10870	COG1228	amidohydrolase
BED35_10880	COG0402	S-adenosylhomocysteine deaminase activity
BED35_10910	COG4942	peptidase
BED35_10920	COG2222	sugar isomerase
BED35_10925	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_10930	COG3716	PTS system mannose fructose sorbose family IID component
BED35_10940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_10950	COG1349	DNA-binding transcription factor activity
BED35_10970	COG1187	pseudouridine synthase activity
BED35_10975	COG0786	glutamate:sodium symporter activity
BED35_10995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED35_11000	COG2226	methyltransferase
BED35_11005	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BED35_11010	COG1801	Protein of unknown function DUF72
BED35_11015	COG1335	isochorismatase
BED35_11020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BED35_11025	COG0494	nUDIX hydrolase
BED35_11030	COG0217	transcriptional regulatory protein
BED35_11035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BED35_11040	COG0632	four-way junction helicase activity
BED35_11045	COG2255	four-way junction helicase activity
BED35_11050	COG3104	oligopeptide transport
BED35_11055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED35_11060	COG1121	(ABC) transporter
BED35_11065	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BED35_11070	COG0739	heme binding
BED35_11075	COG1560	Kdo2-lipid A biosynthetic process
BED35_11090	COG0469	pyruvate kinase activity
BED35_11095	COG1737	Transcriptional regulator
BED35_11100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BED35_11105	COG0800	Aldolase
BED35_11110	COG2076	Multidrug Resistance protein
BED35_11115	COG2076	Multidrug Resistance protein
BED35_11120	COG0251	oxidation-reduction process
BED35_11125	COG1199	ATP-dependent helicase activity
BED35_11140	COG0318	PFAM AMP-dependent synthetase and ligase
BED35_11145	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BED35_11150	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BED35_11155	COG2894	cell division
BED35_11160	COG0850	regulation of cytokinetic process
BED35_11170	COG3100	YcgL domain-containing protein
BED35_11175	COG2951	lytic endotransglycosylase activity
BED35_11180	COG0179	Fumarylacetoacetate (FAA) hydrolase
BED35_11185	COG2983	Belongs to the UPF0260 family
BED35_11210	COG0668	transmembrane transport
BED35_11215	COG0625	glutathione transferase activity
BED35_11265	COG2814	Major facilitator Superfamily
BED35_11275	COG3008	intermembrane lipid transfer
BED35_11280	COG2995	paraquat-inducible protein a
BED35_11285	COG1956	GAF domain-containing protein
BED35_11295	COG0793	Belongs to the peptidase S41A family
BED35_11300	COG0501	Belongs to the peptidase M48B family
BED35_11315	COG0823	Involved in the tonB-independent uptake of proteins
BED35_11325	COG3023	N-Acetylmuramoyl-L-alanine amidase
BED35_11335	COG1988	membrane-bound metal-dependent
BED35_11345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED35_11350	COG1653	transport
BED35_11355	COG3842	ATPase activity
BED35_11360	COG0395	ABC-type sugar transport system, permease component
BED35_11365	COG1175	transmembrane transport
BED35_11375	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_11380	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BED35_11385	COG1917	Cupin 2, conserved barrel domain protein
BED35_11390	COG3328	transposase activity
BED35_11395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED35_11405	COG0583	DNA-binding transcription factor activity
BED35_11410	COG0427	acetyl-CoA hydrolase
BED35_11415	COG1024	Enoyl-CoA hydratase
BED35_11420	COG1703	isobutyryl-CoA mutase activity
BED35_11435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED35_11440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BED35_11445	COG1121	(ABC) transporter
BED35_11450	COG0803	Belongs to the bacterial solute-binding protein 9 family
BED35_11485	COG1811	Na channel or pump
BED35_11490	COG4249	Peptidase C14 caspase catalytic subunit p20
BED35_11495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BED35_11500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BED35_11505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BED35_11510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BED35_11515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BED35_11525	COG0776	regulation of translation
BED35_11540	COG4139	cobalamin transport
BED35_11545	COG0386	Belongs to the glutathione peroxidase family
BED35_11550	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
BED35_11555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BED35_11560	COG0463	Glycosyl transferase, family 2
BED35_11565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED35_11565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BED35_11570	COG0726	polysaccharide deacetylase
BED35_11575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BED35_11580	COG2076	Multidrug Resistance protein
BED35_11585	COG2076	Multidrug Resistance protein
BED35_11590	COG0791	NLP P60 protein
BED35_11630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BED35_11635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BED35_11635	COG0574	Belongs to the PEP-utilizing enzyme family
BED35_11645	COG0628	permease
BED35_11650	COG0277	FAD linked oxidase domain protein
BED35_11650	COG0247	lactate metabolic process
BED35_11655	COG2050	protein possibly involved in aromatic compounds catabolism
BED35_11660	COG0316	Belongs to the HesB IscA family
BED35_11665	COG0719	Fe-S assembly protein
BED35_11670	COG0396	ATPase activity
BED35_11675	COG0719	Fe-S assembly protein
BED35_11685	COG2166	iron-sulfur cluster assembly
BED35_11690	COG1376	ErfK ybiS ycfS ynhG family protein
BED35_11690	COG1388	LysM domain
BED35_11695	COG4238	major outer membrane lipoprotein
BED35_11720	COG0307	riboflavin synthase, alpha
BED35_11725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BED35_11730	COG2814	Major facilitator Superfamily
BED35_11735	COG0583	DNA-binding transcription factor activity
BED35_11740	COG1609	Transcriptional regulator
BED35_11745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BED35_11750	COG0791	NLP P60 protein
BED35_11755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BED35_11760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED35_11770	COG0346	lactoylglutathione lyase activity
BED35_11780	COG1309	transcriptional regulator
BED35_11785	COG2194	sulfuric ester hydrolase activity
BED35_11790	COG3313	Fe-S protein
BED35_11795	COG4989	oxidoreductase activity
BED35_11800	COG1289	transmembrane transporter activity
BED35_11815	COG1846	Transcriptional regulator
BED35_11820	COG3133	Outer membrane lipoprotein
BED35_11825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BED35_11830	COG3895	Periplasmic Protein
BED35_11835	COG0259	pyridoxamine-phosphate oxidase activity
BED35_11840	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BED35_11850	COG0625	glutathione transferase activity
BED35_11875	COG3104	oligopeptide transport
BED35_11885	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED35_11885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED35_11895	COG4172	Belongs to the ABC transporter superfamily
BED35_11905	COG4171	peptide transport system, permease
BED35_11910	COG4168	peptide transport system, permease
BED35_11915	COG4166	transmembrane transport
BED35_11930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BED35_11935	COG1842	Phage shock protein A
BED35_11945	COG1983	PspC domain protein
BED35_11955	COG3106	COG3106 Predicted ATPase
BED35_11960	COG3768	UPF0283 membrane protein
BED35_11980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BED35_11985	COG4948	Mandelate Racemase Muconate Lactonizing
BED35_11990	COG2866	Carboxypeptidase
BED35_11995	COG4166	transmembrane transport
BED35_12000	COG0598	Magnesium transport protein CorA
BED35_12005	COG0037	tRNA processing
BED35_12010	COG0823	Involved in the tonB-independent uptake of proteins
BED35_12025	COG1285	pathogenesis
BED35_12030	COG3042	response to heat
BED35_12035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED35_12040	COG2911	Protein conserved in bacteria
BED35_12050	COG3784	Protein of unknown function (DUF1318)
BED35_12055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BED35_12060	COG1643	Atp-dependent helicase
BED35_12075	COG3591	Belongs to the peptidase S1B family
BED35_12085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BED35_12090	COG2205	protein histidine kinase activity
BED35_12095	COG0745	RESPONSE REGULATOR receiver
BED35_12105	COG0531	amino acid
BED35_12120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BED35_12125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BED35_12130	COG0589	response to stress
BED35_12135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BED35_12140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BED35_12155	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BED35_12160	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_12185	COG1011	Hydrolase
BED35_12190	COG0440	acetolactate synthase activity
BED35_12195	COG0028	Belongs to the TPP enzyme family
BED35_12205	COG3023	N-Acetylmuramoyl-L-alanine amidase
BED35_12245	COG0583	DNA-binding transcription factor activity
BED35_12250	COG2814	Major facilitator Superfamily
BED35_12275	COG0114	fumarate hydratase activity
BED35_12285	COG5339	Protein conserved in bacteria
BED35_12295	COG1609	Transcriptional regulator
BED35_12300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_12300	COG1263	PTS System
BED35_12305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BED35_12310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BED35_12315	COG0385	Bile acid
BED35_12320	COG0673	inositol 2-dehydrogenase activity
BED35_12340	COG1879	ABC-type sugar transport system periplasmic component
BED35_12350	COG2160	L-arabinose isomerase activity
BED35_12360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BED35_12390	COG4657	Part of a membrane complex involved in electron transport
BED35_12400	COG4656	Part of a membrane complex involved in electron transport
BED35_12410	COG2207	Transcriptional regulator
BED35_12410	COG3708	Transcriptional regulator
BED35_12415	COG4658	electron transport chain
BED35_12420	COG4659	FMN binding
BED35_12430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BED35_12505	COG0494	nUDIX hydrolase
BED35_12595	COG1484	DNA-dependent DNA replication
BED35_12675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED35_12695	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BED35_12700	COG1966	Carbon starvation protein
BED35_12705	COG2879	small protein
BED35_12710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BED35_12715	COG1349	DNA-binding transcription factor activity
BED35_12725	COG0235	Class ii aldolase
BED35_12735	COG0023	Translation Initiation Factor
BED35_12740	COG0284	orotidine-5'-phosphate decarboxylase activity
BED35_12750	COG3135	benzoate transporter
BED35_12755	COG1396	sequence-specific DNA binding
BED35_12765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BED35_12770	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BED35_12775	COG0671	phosphoesterase, PA-phosphatase related
BED35_12780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BED35_12800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BED35_12810	COG0616	signal peptide processing
BED35_12815	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_12820	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BED35_12830	COG1187	pseudouridine synthase activity
BED35_12835	COG0009	L-threonylcarbamoyladenylate synthase
BED35_12840	COG0613	PHP domain protein
BED35_12850	COG0512	Glutamine amidotransferase of anthranilate synthase
BED35_12860	COG0135	phosphoribosylanthranilate isomerase activity
BED35_12860	COG0134	indole-3-glycerol-phosphate synthase activity
BED35_12865	COG0133	tryptophan synthase activity
BED35_12870	COG0159	tryptophan synthase activity
BED35_12880	COG3047	cAMP biosynthetic process
BED35_12900	COG2917	probably involved in intracellular septation
BED35_12905	COG1607	acyl-coa hydrolase
BED35_12910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BED35_12915	COG2350	Protein conserved in bacteria
BED35_12930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BED35_12935	COG3099	Belongs to the UPF0263 family
BED35_12945	COG0444	Belongs to the ABC transporter superfamily
BED35_12950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED35_12970	COG2095	MarC family integral membrane protein
BED35_12975	COG1012	belongs to the aldehyde dehydrogenase family
BED35_12975	COG1454	alcohol dehydrogenase
BED35_12980	COG1435	thymidine kinase activity
BED35_12990	COG2916	Histone family protein nucleoid-structuring protein H-NS
BED35_13000	COG0745	RESPONSE REGULATOR receiver
BED35_13005	COG1752	Esterase of the alpha-beta hydrolase superfamily
BED35_13015	COG3012	SEC-C Motif Domain Protein
BED35_13020	COG0788	formyltetrahydrofolate deformylase activity
BED35_13035	COG0583	DNA-binding transcription factor activity
BED35_13040	COG0708	Exodeoxyribonuclease III
BED35_13045	COG0494	nUDIX hydrolase
BED35_13055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BED35_13065	COG0778	Nitroreductase
BED35_13070	COG0616	signal peptide processing
BED35_13075	COG0252	asparaginase activity
BED35_13080	COG1335	isochorismatase
BED35_13095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BED35_13110	COG3713	MltA-interacting MipA family protein
BED35_13115	COG2766	serine protein kinase
BED35_13120	COG2718	Belongs to the UPF0229 family
BED35_13135	COG0583	DNA-binding transcription factor activity
BED35_13145	COG2202	Pas domain
BED35_13145	COG2200	EAL domain
BED35_13145	COG2199	diguanylate cyclase activity
BED35_13155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BED35_13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BED35_13165	COG2719	SpoVR family
BED35_13170	COG2186	Transcriptional regulator
BED35_13175	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BED35_13180	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BED35_13200	COG3142	Participates in the control of copper homeostasis
BED35_13205	COG3102	Protein conserved in bacteria
BED35_13210	COG0018	arginyl-trna synthetase
BED35_13220	COG1702	phosphate starvation-inducible protein PhoH
BED35_13235	COG3658	cytochrome
BED35_13240	COG1215	transferase activity, transferring glycosyl groups
BED35_13255	COG0006	proline dipeptidase activity
BED35_13265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BED35_13290	COG1136	(ABC) transporter
BED35_13290	COG0577	efflux transmembrane transporter activity
BED35_13300	COG0577	efflux transmembrane transporter activity
BED35_13300	COG1136	(ABC) transporter
BED35_13315	COG0672	)-iron permease
BED35_13330	COG2066	Belongs to the glutaminase family
BED35_13335	COG3622	Belongs to the hyi family
BED35_13340	COG0235	Class ii aldolase
BED35_13345	COG3395	kinase activity
BED35_13350	COG1349	DNA-binding transcription factor activity
BED35_13355	COG3290	protein histidine kinase activity
BED35_13360	COG4565	transcriptional regulatory protein
BED35_13365	COG3493	citrate carrier protein
BED35_13385	COG2223	nitrite transmembrane transporter activity
BED35_13390	COG0561	phosphatase activity
BED35_13400	COG3328	transposase activity
BED35_13405	COG0500	methyltransferase
BED35_13415	COG3328	transposase activity
BED35_13460	COG4974	Belongs to the 'phage' integrase family
BED35_13470	COG1276	copper resistance
BED35_13475	COG2372	response to copper ion
BED35_13480	COG1528	Iron-storage protein
BED35_13495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED35_13500	COG1770	oligopeptidase
BED35_13515	COG3141	response to X-ray
BED35_13520	COG0513	Belongs to the DEAD box helicase family
BED35_13525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BED35_13530	COG3140	Belongs to the UPF0181 family
BED35_13540	COG0494	nUDIX hydrolase
BED35_13545	COG1760	l-serine dehydratase
BED35_13555	COG1253	flavin adenine dinucleotide binding
BED35_13560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_13560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_13565	COG3715	PTS system
BED35_13570	COG3716	PTS system mannose fructose sorbose family IID component
BED35_13575	COG4811	Protein of unknown function (DUF986)
BED35_13580	COG1971	Probably functions as a manganese efflux pump
BED35_13590	COG5001	Diguanylate cyclase
BED35_13590	COG3447	MASE1 domain protein
BED35_13590	COG5002	protein histidine kinase activity
BED35_13600	COG2226	methyltransferase
BED35_13605	COG0768	penicillin binding
BED35_13615	COG1278	Cold shock
BED35_13660	COG2207	Transcriptional regulator
BED35_13680	COG1132	(ABC) transporter
BED35_13700	COG3706	GGDEF domain
BED35_13700	COG2203	Gaf domain
BED35_13700	COG5001	Diguanylate cyclase
BED35_13700	COG4251	negative regulation of phosphorylation
BED35_13715	COG3755	Protein conserved in bacteria
BED35_13740	COG1733	regulation of RNA biosynthetic process
BED35_13745	COG0702	epimerase
BED35_13750	COG2873	o-acetylhomoserine
BED35_13770	COG0840	transmembrane signaling receptor activity
BED35_13790	COG2211	Major facilitator Superfamily
BED35_13805	COG0538	isocitrate dehydrogenase activity
BED35_13835	COG0538	isocitrate dehydrogenase activity
BED35_13840	COG1187	pseudouridine synthase activity
BED35_13850	COG0482	sulfurtransferase activity
BED35_13855	COG2915	High frequency lysogenization protein hflD homolog
BED35_13860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BED35_13870	COG0745	RESPONSE REGULATOR receiver
BED35_13890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BED35_13900	COG4591	ABC-type transport system involved in lipoprotein release permease component
BED35_13910	COG4591	ABC-type transport system involved in lipoprotein release permease component
BED35_13915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BED35_13920	COG3134	Outer membrane lipoprotein
BED35_13925	COG1252	NADH dehydrogenase
BED35_13930	COG3150	esterase
BED35_13935	COG1472	Belongs to the glycosyl hydrolase 3 family
BED35_13940	COG0510	thiamine kinase activity
BED35_13945	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
BED35_13950	COG5633	Lipoprotein
BED35_13955	COG0537	adenosine 5'-monophosphoramidase activity
BED35_13960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BED35_13970	COG0641	radical SAM
BED35_13990	COG1263	PTS System
BED35_13990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_13995	COG0084	hydrolase, TatD family'
BED35_14000	COG0470	DNA polymerase III
BED35_14005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BED35_14010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BED35_14015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BED35_14020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED35_14030	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_14035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BED35_14040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BED35_14045	COG0416	fatty acid biosynthetic process
BED35_14050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BED35_14055	COG1399	metal-binding, possibly nucleic acid-binding protein
BED35_14065	COG0564	pseudouridine synthase activity
BED35_14070	COG1530	ribonuclease E activity
BED35_14075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED35_14080	COG0418	dihydroorotase activity
BED35_14105	COG0628	permease
BED35_14140	COG1560	Kdo2-lipid A biosynthetic process
BED35_14150	COG2259	Doxx family
BED35_14160	COG2814	Major facilitator Superfamily
BED35_14165	COG3104	oligopeptide transport
BED35_14170	COG2943	transferase activity, transferring hexosyl groups
BED35_14175	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BED35_14195	COG3263	regulation of cellular component size
BED35_14205	COG3916	Acyl-homoserine-lactone synthase
BED35_14210	COG2771	luxR family
BED35_14215	COG4235	cytochrome complex assembly
BED35_14225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED35_14235	COG3301	Polysulphide reductase, NrfD
BED35_14240	COG0437	4 iron, 4 sulfur cluster binding
BED35_14245	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BED35_14260	COG2920	part of a sulfur-relay system
BED35_14265	COG1254	Belongs to the acylphosphatase family
BED35_14280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BED35_14285	COG3785	DNA binding
BED35_14290	COG1832	CoA-binding protein
BED35_14295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
BED35_14300	COG1803	Methylglyoxal synthase
BED35_14305	COG0210	DNA helicase
BED35_14310	COG3304	Inner membrane component domain
BED35_14315	COG1289	transmembrane transporter activity
BED35_14320	COG3070	regulator of competence-specific genes
BED35_14330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BED35_14330	COG2885	chlorophyll binding
BED35_14335	COG3120	sequence-specific DNA binding
BED35_14340	COG1067	ATP-dependent peptidase activity
BED35_14345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BED35_14355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED35_14360	COG3009	Protein conserved in bacteria
BED35_14365	COG3008	intermembrane lipid transfer
BED35_14365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BED35_14370	COG2995	paraquat-inducible protein a
BED35_14375	COG0488	(ABC) transporter
BED35_14380	COG0116	Belongs to the methyltransferase superfamily
BED35_14380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BED35_14385	COG0633	Ferredoxin
BED35_14385	COG3217	Mosc domain protein beta barrel domain protein
BED35_14395	COG0167	dihydroorotate dehydrogenase activity
BED35_14400	COG0308	aminopeptidase N
BED35_14405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BED35_14410	COG0017	Asparaginyl-tRNA synthetase
BED35_14420	COG1448	Aminotransferase
BED35_14430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BED35_14435	COG3108	Peptidase M15
BED35_14440	COG2989	Protein conserved in bacteria
BED35_14445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BED35_14450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BED35_14455	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BED35_14460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED35_14465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BED35_14470	COG3173	Aminoglycoside phosphotransferase
BED35_14475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BED35_14480	COG2835	tetraacyldisaccharide 4'-kinase activity
BED35_14485	COG1278	Cold shock
BED35_14490	COG1278	Cold shock
BED35_14495	COG5383	Protein conserved in bacteria
BED35_14500	COG1663	tetraacyldisaccharide 4'-kinase activity
BED35_14510	COG0658	competence protein
BED35_14510	COG2333	competence protein COMEC
BED35_14515	COG0776	regulation of translation
BED35_14520	COG0539	negative regulation of cytoplasmic translation
BED35_14525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BED35_14530	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BED35_14535	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BED35_14540	COG2323	membrane
BED35_14545	COG0252	asparaginase activity
BED35_14550	COG1944	ATP diphosphatase activity
BED35_14555	COG2116	formate transmembrane transporter activity
BED35_14560	COG1882	Formate acetyltransferase
BED35_14565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BED35_14570	COG2814	Major facilitator Superfamily
BED35_14575	COG3328	transposase activity
BED35_14585	COG3547	Transposase (IS116 IS110 IS902 family)
BED35_14590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BED35_14595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BED35_14600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BED35_14605	COG1674	ftsk spoiiie
BED35_14605	COG3107	peptidoglycan biosynthetic process
BED35_14610	COG1522	sequence-specific DNA binding
BED35_14615	COG0492	ferredoxin-NADP+ reductase activity
BED35_14625	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BED35_14630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BED35_14635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BED35_14640	COG0542	response to heat
BED35_14645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BED35_14650	COG1278	Cold shock
BED35_14660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_14665	COG2990	Protein conserved in bacteria
BED35_14670	COG3593	DNA synthesis involved in DNA repair
BED35_14675	COG2431	L-lysine efflux transmembrane transporter activity
BED35_14680	COG1151	hydroxylamine reductase activity
BED35_14685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BED35_14690	COG0028	Belongs to the TPP enzyme family
BED35_14700	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BED35_14705	COG0702	epimerase
BED35_14710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED35_14720	COG1126	abc transporter atp-binding protein
BED35_14725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED35_14730	COG4215	(ABC) transporter
BED35_14735	COG4160	amino acid transport
BED35_14740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED35_14745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED35_14755	COG1177	transmembrane transport
BED35_14760	COG1176	ABC-type spermidine putrescine transport system, permease component I
BED35_14765	COG3842	ATPase activity
BED35_14770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BED35_14785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED35_14790	COG2985	domain, Protein
BED35_14790	COG0569	domain protein
BED35_14800	COG0671	phosphoesterase, PA-phosphatase related
BED35_14805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BED35_14810	COG1349	DNA-binding transcription factor activity
BED35_14815	COG0814	amino acid
BED35_14820	COG1760	l-serine dehydratase
BED35_14830	COG1686	Belongs to the peptidase S11 family
BED35_14840	COG0626	cystathionine gamma-synthase activity
BED35_14845	COG2011	ABC-type metal ion transport system permease component
BED35_14870	COG0625	glutathione transferase activity
BED35_14875	COG4771	TonB-dependent receptor
BED35_14885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED35_14890	COG0833	amino acid
BED35_14895	COG0583	DNA-binding transcription factor activity
BED35_14910	COG2855	membrane
BED35_14915	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BED35_14940	COG3710	Transcriptional regulator
BED35_14945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BED35_14945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BED35_14945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BED35_14950	COG1105	Belongs to the carbohydrate kinase PfkB family
BED35_14965	COG3005	denitrification pathway
BED35_14970	COG0243	molybdopterin cofactor binding
BED35_14985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BED35_14990	COG1312	Catalyzes the dehydration of D-mannonate
BED35_15000	COG0246	Mannitol dehydrogenase
BED35_15005	COG2186	Transcriptional regulator
BED35_15015	COG0523	cobalamin synthesis protein
BED35_15020	COG0671	phosphoesterase, PA-phosphatase related
BED35_15025	COG0791	NLP P60 protein
BED35_15035	COG2200	EAL domain
BED35_15040	COG4166	transmembrane transport
BED35_15045	COG4174	ABC transporter (Permease)
BED35_15050	COG4239	(ABC) transporter, permease
BED35_15055	COG4172	Belongs to the ABC transporter superfamily
BED35_15065	COG2814	Major facilitator Superfamily
BED35_15070	COG1187	pseudouridine synthase activity
BED35_15075	COG1061	Type III restriction enzyme res subunit
BED35_15080	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BED35_15085	COG3081	Nucleoid-associated protein
BED35_15090	COG3082	Protein of unknown function (DUF1414)
BED35_15115	COG3328	transposase activity
BED35_15130	COG2801	Transposase and inactivated derivatives
BED35_15145	COG3338	carbonate dehydratase activity
BED35_15150	COG2723	6-phospho-beta-galactosidase activity
BED35_15155	COG1263	PTS System
BED35_15155	COG2190	(PTS) system
BED35_15155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_15160	COG1737	Transcriptional regulator
BED35_15215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BED35_15230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BED35_15245	COG2223	nitrite transmembrane transporter activity
BED35_15250	COG2198	Histidine kinase
BED35_15250	COG0642	Histidine kinase
BED35_15255	COG2197	response regulator
BED35_15260	COG2205	protein histidine kinase activity
BED35_15260	COG0784	Response regulator, receiver
BED35_15270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BED35_15275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BED35_15290	COG4574	serine-type endopeptidase inhibitor activity
BED35_15310	COG0814	amino acid
BED35_15330	COG1441	menaquinone biosynthetic process
BED35_15335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BED35_15340	COG0596	Alpha beta hydrolase
BED35_15345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BED35_15350	COG1169	isochorismate synthase
BED35_15355	COG4575	ribosome binding
BED35_15360	COG0129	dihydroxy-acid dehydratase activity
BED35_15365	COG4702	Belongs to the UPF0303 family
BED35_15375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED35_15380	COG1609	Transcriptional regulator
BED35_15385	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_15390	COG3265	gluconokinase activity
BED35_15410	COG1007	ATP synthesis coupled electron transport
BED35_15415	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED35_15420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BED35_15425	COG0713	ATP synthesis coupled electron transport
BED35_15430	COG0839	Belongs to the complex I subunit 6 family
BED35_15435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED35_15440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BED35_15445	COG1034	ATP synthesis coupled electron transport
BED35_15455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BED35_15460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED35_15460	COG0649	NAD binding
BED35_15465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED35_15470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BED35_15475	COG0583	DNA-binding transcription factor activity
BED35_15480	COG0436	Aminotransferase
BED35_15485	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BED35_15490	COG0471	metal ion transport
BED35_15490	COG0490	domain, Protein
BED35_15500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED35_15505	COG3013	Belongs to the UPF0304 family
BED35_15510	COG3092	negative regulation of chromosome organization
BED35_15520	COG0857	belongs to the CobB CobQ family
BED35_15520	COG0280	phosphate acetyltransferase
BED35_15525	COG1609	Transcriptional regulator
BED35_15530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_15540	COG3037	sugar-specific permease SgaT UlaA
BED35_15550	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BED35_15565	COG1090	epimerase
BED35_15575	COG4598	ABC transporter
BED35_15580	COG4160	amino acid transport
BED35_15585	COG4215	(ABC) transporter
BED35_15590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED35_15595	COG0163	prenyltransferase activity
BED35_15600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BED35_15605	COG1286	toxin biosynthetic process
BED35_15610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BED35_15615	COG0285	dihydrofolate synthase activity
BED35_15620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BED35_15625	COG0586	Pfam SNARE associated Golgi protein
BED35_15635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BED35_15640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BED35_15655	COG0697	spore germination
BED35_15660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED35_15665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED35_15690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BED35_15700	COG1609	Transcriptional regulator
BED35_15710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED35_15715	COG2723	6-phospho-beta-galactosidase activity
BED35_15720	COG1447	Phosphotransferase system cellobiose-specific component IIA
BED35_15730	COG1794	racemase activity, acting on amino acids and derivatives
BED35_15740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BED35_15745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BED35_15745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BED35_15755	COG3101	peptidyl-lysine hydroxylation
BED35_15760	COG0730	response to heat
BED35_15765	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BED35_15770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BED35_15775	COG2890	protein-(glutamine-N5) methyltransferase activity
BED35_15780	COG2840	Smr protein MutS2
BED35_15785	COG2062	phosphohistidine phosphatase, SixA
BED35_15790	COG1024	Enoyl-CoA hydratase
BED35_15790	COG1250	3-hydroxyacyl-CoA dehydrogenase
BED35_15795	COG0183	Belongs to the thiolase family
BED35_15800	COG3691	Protein conserved in bacteria
BED35_15815	COG4235	cytochrome complex assembly
BED35_15815	COG3088	subunit of a heme lyase
BED35_15825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BED35_15830	COG1138	Cytochrome C-type biogenesis protein
BED35_15835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BED35_15840	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED35_15845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED35_15850	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BED35_15865	COG2116	formate transmembrane transporter activity
BED35_15875	COG0582	viral genome integration into host DNA
BED35_15935	COG2824	Alkylphosphonate utilization operon protein PhnA
BED35_15940	COG1695	Transcriptional regulator
BED35_15950	COG2723	6-phospho-beta-galactosidase activity
BED35_15955	COG1263	PTS System
BED35_15955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BED35_15960	COG1609	Transcriptional regulator
BED35_15965	COG2353	YceI-like domain
BED35_15970	COG3038	cytochrome b561
BED35_15975	COG2755	lipolytic protein G-D-S-L family
BED35_15975	COG0657	acetylesterase activity
BED35_15995	COG1127	ABC transporter
BED35_16000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BED35_16020	COG0531	amino acid
BED35_16025	COG2951	lytic endotransglycosylase activity
BED35_16055	COG1598	PFAM Uncharacterised protein family UPF0150
BED35_16060	COG3038	cytochrome b561
BED35_16065	COG0436	Aminotransferase
BED35_16085	COG3279	Response regulator of the LytR AlgR family
BED35_16095	COG0837	glucose binding
BED35_16110	COG3961	Belongs to the TPP enzyme family
BED35_16115	COG0667	Aldo Keto reductase
BED35_16125	COG1914	H( )-stimulated, divalent metal cation uptake system
BED35_16130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED35_16160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BED35_16185	COG3530	Putative quorum-sensing-regulated virulence factor
BED35_16190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BED35_16205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BED35_16210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_16215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BED35_16220	COG2190	(PTS) system
BED35_16225	COG2205	protein histidine kinase activity
BED35_16230	COG0745	RESPONSE REGULATOR receiver
BED35_16235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_16255	COG4208	sulfate ABC transporter
BED35_16260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BED35_16265	COG4150	thiosulfate binding
BED35_16275	COG1737	Transcriptional regulator
BED35_16280	COG2731	YhcH YjgK YiaL family protein
BED35_16295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BED35_16305	COG2837	iron assimilation
BED35_16315	COG3111	PFAM Bacterial OB fold (BOF) protein
BED35_16320	COG0456	acetyltransferase
BED35_16325	COG0408	coproporphyrinogen oxidase activity
BED35_16330	COG1671	Belongs to the UPF0178 family
BED35_16345	COG0494	nUDIX hydrolase
BED35_16355	COG3043	anaerobic respiration
BED35_16360	COG0243	molybdopterin cofactor binding
BED35_16365	COG3062	negative regulation of establishment of protein localization
BED35_16375	COG2197	response regulator
BED35_16385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED35_16405	COG1393	Belongs to the ArsC family
BED35_16410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BED35_16415	COG1876	peptidase activity
BED35_16460	COG0400	carboxylic ester hydrolase activity
BED35_16470	COG1444	tRNA N-acetyltransferase activity
BED35_16475	COG2707	UPF0756 membrane protein
BED35_16480	COG2321	neutral zinc metallopeptidase
BED35_16485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BED35_16490	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BED35_16495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BED35_16500	COG2716	regulation of RNA biosynthetic process
BED35_16505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BED35_16510	COG0628	permease
BED35_16515	COG4783	chaperone-mediated protein folding
BED35_16520	COG1393	Belongs to the ArsC family
BED35_16525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BED35_16530	COG2233	PERMEase
BED35_16535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BED35_16545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BED35_16550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BED35_16565	COG0581	inorganic phosphate transmembrane transporter activity
BED35_16570	COG0573	inorganic phosphate transmembrane transporter activity
BED35_16580	COG0248	Ppx GppA phosphatase
BED35_16595	COG3447	MASE1 domain protein
BED35_16595	COG5001	Diguanylate cyclase
BED35_16595	COG5002	protein histidine kinase activity
BED35_16600	COG0443	Heat shock 70 kDa protein
BED35_16605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_16615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED35_16620	COG0477	Major facilitator Superfamily
BED35_16625	COG2205	protein histidine kinase activity
BED35_16630	COG0745	RESPONSE REGULATOR receiver
BED35_16635	COG3422	double-strand break repair
BED35_16645	COG1597	lipid kinase activity
BED35_16650	COG3730	PTS system glucitol sorbitol-specific
BED35_16665	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_16670	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_16675	COG1349	DNA-binding transcription factor activity
BED35_16695	COG0351	phosphomethylpyrimidine kinase
BED35_16725	COG3328	transposase activity
BED35_16790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BED35_16790	COG0519	Catalyzes the synthesis of GMP from XMP
BED35_16795	COG0517	IMP dehydrogenase activity
BED35_16795	COG0516	GMP reductase activity
BED35_16800	COG1570	exodeoxyribonuclease VII activity
BED35_16805	COG1645	bacterial-type flagellum-dependent swarming motility
BED35_16820	COG1160	GTP binding
BED35_16830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED35_16840	COG0124	histidyl-tRNA synthetase
BED35_16845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BED35_16850	COG1426	Protein conserved in bacteria
BED35_16860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BED35_16875	COG4953	penicillin-binding protein 1C
BED35_16880	COG2373	Large extracellular alpha-helical protein
BED35_16885	COG3468	outer membrane autotransporter barrel domain protein
BED35_16900	COG2975	iron-sulfur cluster assembly
BED35_16905	COG0633	Ferredoxin
BED35_16910	COG0443	Heat shock 70 kDa protein
BED35_16915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BED35_16920	COG0316	Belongs to the HesB IscA family
BED35_16925	COG0822	iron-sulfur transferase activity
BED35_16935	COG1959	2 iron, 2 sulfur cluster binding
BED35_16940	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BED35_16945	COG0483	inositol monophosphate 1-phosphatase activity
BED35_16950	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BED35_16955	COG3683	transport system, periplasmic component
BED35_16965	COG2814	Major facilitator Superfamily
BED35_16970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BED35_16975	COG1017	nitric oxide dioxygenase activity
BED35_16975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BED35_16980	COG2188	Transcriptional regulator
BED35_16990	COG3457	Alanine racemase
BED35_16995	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BED35_17010	COG0347	Belongs to the P(II) protein family
BED35_17015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BED35_17015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BED35_17020	COG2204	response regulator
BED35_17025	COG3170	Tfp pilus assembly protein FimV
BED35_17030	COG2205	protein histidine kinase activity
BED35_17045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BED35_17050	COG0590	tRNA wobble adenosine to inosine editing
BED35_17060	COG0560	Phosphoserine phosphatase
BED35_17070	COG1737	Transcriptional regulator
BED35_17075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BED35_17085	COG0736	holo-[acyl-carrier-protein] synthase activity
BED35_17090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BED35_17095	COG1381	Involved in DNA repair and RecF pathway recombination
BED35_17100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BED35_17105	COG0571	ribonuclease III activity
BED35_17110	COG0681	Belongs to the peptidase S26 family
BED35_17115	COG0481	GTPase activity
BED35_17125	COG3086	response to oxidative stress
BED35_17130	COG3026	antisigma factor binding
BED35_17135	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BED35_17145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BED35_17150	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BED35_17155	COG0513	Belongs to the DEAD box helicase family
BED35_17185	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BED35_17190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BED35_17195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BED35_17200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BED35_17205	COG0497	DNA recombination
BED35_17210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BED35_17220	COG2867	negative regulation of translational initiation
BED35_17225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BED35_17240	COG0659	secondary active sulfate transmembrane transporter activity
BED35_17245	COG3394	polysaccharide catabolic process
BED35_17250	COG2169	Transcriptional regulator
BED35_17250	COG1917	Cupin 2, conserved barrel domain protein
BED35_17255	COG1447	Phosphotransferase system cellobiose-specific component IIA
BED35_17260	COG2723	6-phospho-beta-galactosidase activity
BED35_17265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED35_17270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BED35_17285	COG0667	Aldo Keto reductase
BED35_17295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BED35_17300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BED35_17310	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BED35_17315	COG4413	Urea transporter
BED35_17320	COG0829	nickel cation binding
BED35_17325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BED35_17330	COG0830	nickel cation binding
BED35_17340	COG0804	urea catabolic process
BED35_17345	COG0832	Belongs to the urease beta subunit family
BED35_17355	COG1124	(ABC) transporter
BED35_17365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BED35_17405	COG1278	Cold shock
BED35_17425	COG0477	Major facilitator Superfamily
BED35_17430	COG2207	Transcriptional regulator
BED35_17445	COG4575	ribosome binding
BED35_17455	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BED35_17465	COG1780	Probably involved in ribonucleotide reductase function
BED35_17475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BED35_17485	COG4176	ABC-type proline glycine betaine transport system permease component
BED35_17490	COG2113	Glycine betaine
BED35_17500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BED35_17505	COG0328	RNA-DNA hybrid ribonuclease activity
BED35_17510	COG2226	methyltransferase
BED35_17515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BED35_17520	COG0741	lytic transglycosylase activity
BED35_17520	COG1388	LysM domain
BED35_17530	COG3021	interspecies interaction between organisms
BED35_17535	COG2814	Major facilitator Superfamily
BED35_17540	COG0583	DNA-binding transcription factor activity
BED35_17545	COG0656	L-ascorbic acid biosynthetic process
BED35_17555	COG3328	transposase activity
BED35_17600	COG2011	ABC-type metal ion transport system permease component
BED35_17605	COG1464	Belongs to the NlpA lipoprotein family
BED35_17615	COG1720	tRNA m6t6A37 methyltransferase activity
BED35_17620	COG0442	prolyl-tRNA aminoacylation
BED35_17625	COG3015	lipoprotein NlpE involved in copper resistance
BED35_17635	COG4681	YaeQ
BED35_17645	COG4568	rho-dependent transcription termination
BED35_17655	COG0037	tRNA processing
BED35_17660	COG0346	lactoylglutathione lyase activity
BED35_17670	COG0825	malonyl-CoA metabolic process
BED35_17680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BED35_17685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED35_17695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BED35_17700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BED35_17705	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BED35_17715	COG0750	zinc metalloprotease
BED35_17720	COG0575	Belongs to the CDS family
BED35_17725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BED35_17730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BED35_17735	COG0233	cytoplasmic translational termination
BED35_17740	COG0528	UMP kinase activity
BED35_17745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BED35_17750	COG0052	Belongs to the universal ribosomal protein uS2 family
BED35_17760	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BED35_17765	COG2171	N-acyltransferase activity
BED35_17780	COG0564	pseudouridine synthase activity
BED35_17785	COG3098	single-species biofilm formation
BED35_17795	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BED35_17795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BED35_17800	COG1611	Belongs to the LOG family
BED35_17805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED35_17815	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BED35_17820	COG2363	Small membrane protein
BED35_17825	COG0583	DNA-binding transcription factor activity
BED35_17835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BED35_17840	COG2166	iron-sulfur cluster assembly
BED35_17845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BED35_17850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BED35_17870	COG0860	N-Acetylmuramoyl-L-alanine amidase
BED35_17875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BED35_17875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BED35_17880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BED35_17885	COG1074	ATP-dependent DNA helicase activity
BED35_17890	COG1025	Belongs to the peptidase M16 family
BED35_17895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BED35_17900	COG4967	type IV pilus modification protein PilV
BED35_17920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BED35_17925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BED35_17945	COG3066	DNA modification
BED35_17950	COG0861	Integral membrane protein TerC family
BED35_17955	COG0667	Aldo Keto reductase
BED35_17965	COG0204	Acyl-transferase
BED35_17965	COG0318	PFAM AMP-dependent synthetase and ligase
BED35_17975	COG1609	Transcriptional regulator
BED35_17980	COG0019	diaminopimelate decarboxylase activity
BED35_17985	COG0583	DNA-binding transcription factor activity
BED35_17990	COG2814	Major facilitator Superfamily
BED35_18060	COG2165	general secretion pathway protein
BED35_18090	COG0288	reversible hydration of carbon dioxide
BED35_18095	COG1733	regulation of RNA biosynthetic process
BED35_18100	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_18110	COG0484	heat shock protein binding
BED35_18120	COG3706	GGDEF domain
BED35_18125	COG4319	ketosteroid isomerase
BED35_18140	COG3328	transposase activity
BED35_18145	COG2944	sequence-specific DNA binding
BED35_18245	COG0582	viral genome integration into host DNA
BED35_18255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BED35_18260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BED35_18265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BED35_18270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BED35_18275	COG4974	Belongs to the 'phage' integrase family
BED35_18280	COG0716	FMN binding
BED35_18285	COG4452	Inner membrane protein CreD
BED35_18290	COG2205	protein histidine kinase activity
BED35_18295	COG0745	RESPONSE REGULATOR receiver
BED35_18305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BED35_18310	COG0354	folic acid binding
BED35_18320	COG1272	protein, Hemolysin III
BED35_18330	COG1028	Short-chain dehydrogenase reductase Sdr
BED35_18340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BED35_18340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BED35_18345	COG0509	glycine decarboxylation via glycine cleavage system
BED35_18350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BED35_18355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED35_18360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BED35_18365	COG0006	proline dipeptidase activity
BED35_18370	COG3079	Belongs to the UPF0149 family
BED35_18375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BED35_18385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BED35_18390	COG0148	phosphopyruvate hydratase activity
BED35_18395	COG0504	CTP synthase activity
BED35_18400	COG3956	TIGRFAM MazG family protein
BED35_18405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BED35_18410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BED35_18415	COG3850	Histidine kinase
BED35_18415	COG2205	protein histidine kinase activity
BED35_18415	COG4999	Histidine kinase
BED35_18415	COG3437	response regulator, receiver
BED35_18420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BED35_18425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BED35_18430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BED35_18440	COG2860	membrane
BED35_18445	COG0316	Belongs to the HesB IscA family
BED35_18455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BED35_18460	COG2223	nitrite transmembrane transporter activity
BED35_18465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED35_18470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BED35_18475	COG1120	ATPase activity
BED35_18480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BED35_18485	COG1643	Atp-dependent helicase
BED35_18490	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BED35_18495	COG1489	DNA binding
BED35_18500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BED35_18515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BED35_18520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BED35_18525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BED35_18530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BED35_18535	COG0726	polysaccharide deacetylase
BED35_18540	COG0842	Transport permease protein
BED35_18545	COG1131	(ABC) transporter
BED35_18550	COG0288	reversible hydration of carbon dioxide
BED35_18560	COG2132	Multicopper oxidase
BED35_18570	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BED35_18575	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BED35_18585	COG0697	spore germination
BED35_18590	COG3112	Uncharacterised protein family (UPF0231)
BED35_18615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BED35_18620	COG0508	dehydrogenase complex catalyzes the overall conversion of
BED35_18625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BED35_18630	COG2186	Transcriptional regulator
BED35_18635	COG1113	amino acid transport
BED35_18640	COG3725	Membrane protein required for beta-lactamase induction
BED35_18655	COG4969	Belongs to the N-Me-Phe pilin family
BED35_18660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BED35_18665	COG1459	type II secretion system
BED35_18670	COG0516	GMP reductase activity
BED35_18675	COG0237	dephospho-CoA kinase activity
BED35_18685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BED35_18690	COG0494	nUDIX hydrolase
BED35_18695	COG0653	protein targeting
BED35_18715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BED35_18720	COG0849	cell division
BED35_18725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BED35_18735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BED35_18740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BED35_18745	COG0772	Belongs to the SEDS family
BED35_18755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED35_18760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BED35_18765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BED35_18770	COG0768	penicillin binding
BED35_18780	COG0275	rRNA processing
BED35_18785	COG2001	Belongs to the MraZ family
BED35_18795	COG1609	Transcriptional regulator
BED35_18805	COG0028	Belongs to the TPP enzyme family
BED35_18810	COG1022	Amp-dependent synthetase and ligase
BED35_18820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BED35_18825	COG0473	3-isopropylmalate dehydrogenase activity
BED35_18830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BED35_18850	COG2814	Major facilitator Superfamily
BED35_18865	COG4533	DNA binding
BED35_18880	COG4143	(ABC) transporter
BED35_18885	COG1178	ABC-type Fe3 transport system permease component
BED35_18895	COG0586	Pfam SNARE associated Golgi protein
BED35_18900	COG0417	DNA replication proofreading
BED35_18905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BED35_18915	COG0564	pseudouridine synthase activity
BED35_18920	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BED35_18925	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BED35_18930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED35_18940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BED35_18945	COG2967	ApaG domain
BED35_18950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BED35_18955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BED35_18960	COG3610	response to peptide
BED35_18965	COG2966	Psort location CytoplasmicMembrane, score
BED35_18970	COG1280	lysine exporter protein (LysE YggA)
BED35_18975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BED35_18980	COG0505	Belongs to the CarA family
BED35_18985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BED35_18990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BED35_18995	COG1047	Peptidyl-prolyl cis-trans
BED35_19000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BED35_19005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BED35_19010	COG0196	riboflavin kinase activity
BED35_19020	COG0268	Binds directly to 16S ribosomal RNA
BED35_19025	COG0583	DNA-binding transcription factor activity
BED35_19030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BED35_19035	COG0484	heat shock protein binding
BED35_19040	COG0443	Heat shock 70 kDa protein
BED35_19045	COG1584	GPR1 FUN34 yaaH family protein
BED35_19060	COG0521	Mo-molybdopterin cofactor biosynthetic process
BED35_19065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BED35_19070	COG3022	response to hydroperoxide
BED35_19085	COG0083	homoserine kinase activity
BED35_19100	COG0745	RESPONSE REGULATOR receiver
BED35_19105	COG3045	CreA protein
BED35_19110	COG3708	Transcriptional regulator
BED35_19110	COG2207	Transcriptional regulator
BED35_19115	COG0406	alpha-ribazole phosphatase activity
BED35_19125	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BED35_19130	COG0741	lytic transglycosylase activity
BED35_19135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BED35_19145	COG2199	diguanylate cyclase activity
BED35_19150	COG2885	chlorophyll binding
BED35_19155	COG0488	(ABC) transporter
BED35_19170	COG0604	alcohol dehydrogenase
BED35_19185	COG0560	Phosphoserine phosphatase
BED35_19190	COG3726	membrane protein affecting hemolysin expression
BED35_19195	COG0813	purine-nucleoside phosphorylase activity
BED35_19200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BED35_19205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BED35_19210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BED35_19215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED35_19220	COG0084	hydrolase, TatD family'
BED35_19225	COG4667	esterase of the alpha-beta hydrolase superfamily
BED35_19235	COG2823	Periplasmic or secreted lipoprotein
BED35_19240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BED35_19245	COG0456	acetyltransferase
BED35_19250	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BED35_19255	COG2813	Specifically methylates the guanine in position
BED35_19260	COG0667	Aldo Keto reductase
BED35_19280	COG3706	GGDEF domain
BED35_19285	COG4772	TonB-dependent receptor
BED35_19320	COG3284	Transcriptional regulator
BED35_19355	COG2192	nodulation
BED35_19370	COG1461	Dihydroxyacetone kinase
BED35_19375	COG2376	Dihydroxyacetone kinase
BED35_19385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BED35_19390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BED35_19395	COG2235	arginine
BED35_19410	COG0859	PFAM glycosyl transferase family 9
BED35_19415	COG1070	Carbohydrate kinase
BED35_19420	COG2390	Transcriptional regulator
BED35_19425	COG1129	ABC transporter
BED35_19430	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_19435	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_19440	COG1879	ABC-type sugar transport system periplasmic component
BED35_19445	COG1830	Aldolase
BED35_19450	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BED35_19465	COG3328	transposase activity
BED35_19495	COG0795	lipopolysaccharide-transporting ATPase activity
BED35_19500	COG0795	lipopolysaccharide-transporting ATPase activity
BED35_19505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BED35_19510	COG2927	DNA polymerase III (CHI subunit)
BED35_19525	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BED35_19535	COG2731	YhcH YjgK YiaL family protein
BED35_19545	COG0601	transmembrane transport
BED35_19555	COG0444	Belongs to the ABC transporter superfamily
BED35_19560	COG4608	Belongs to the ABC transporter superfamily
BED35_19590	COG2188	Transcriptional regulator
BED35_19595	COG3624	Phosphonate C-P lyase system protein PhnG
BED35_19600	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BED35_19605	COG3626	phosphonate metabolism
BED35_19610	COG3627	carbon phosphorus lyase activity
BED35_19615	COG4107	phosphonate C-P lyase system protein PhnK
BED35_19620	COG4778	phosphonate C-P lyase system protein PhnL
BED35_19625	COG3454	Phosphonate metabolism
BED35_19635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BED35_19640	COG0702	epimerase
BED35_19655	COG3787	Belongs to the UPF0306 family
BED35_19665	COG3842	ATPase activity
BED35_19670	COG0395	ABC-type sugar transport system, permease component
BED35_19680	COG1653	transport
BED35_19695	COG1982	Orn Lys Arg decarboxylase major
BED35_19700	COG0531	amino acid
BED35_19710	COG3153	acetyltransferase
BED35_19730	COG3681	Belongs to the UPF0597 family
BED35_19735	COG0814	amino acid
BED35_19745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BED35_19755	COG0513	Belongs to the DEAD box helicase family
BED35_19765	COG1185	polyribonucleotide nucleotidyltransferase activity
BED35_19770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BED35_19775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BED35_19780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BED35_19785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BED35_19790	COG0195	Participates in both transcription termination and antitermination
BED35_19795	COG0779	Required for maturation of 30S ribosomal subunits
BED35_19810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BED35_19815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BED35_19820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BED35_19825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BED35_19830	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BED35_19835	COG1534	Rna-binding protein
BED35_19840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BED35_19845	COG2027	D-alanyl-D-alanine carboxypeptidase
BED35_19850	COG0745	RESPONSE REGULATOR receiver
BED35_19855	COG0642	Histidine kinase
BED35_19860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BED35_19865	COG0697	spore germination
BED35_19870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BED35_19875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BED35_19880	COG0142	geranyltranstransferase activity
BED35_19890	COG3423	Transcriptional regulator
BED35_19895	COG0039	L-malate dehydrogenase activity
BED35_19900	COG1438	arginine binding
BED35_19910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BED35_19915	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BED35_19925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BED35_19930	COG2105	PFAM AIG2 family protein
BED35_19945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BED35_19950	COG1253	flavin adenine dinucleotide binding
BED35_19960	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BED35_19965	COG1218	3'(2'),5'-bisphosphate nucleotidase
BED35_19970	COG0737	Belongs to the 5'-nucleotidase family
BED35_19980	COG0545	Peptidyl-prolyl cis-trans isomerase
BED35_19985	COG3061	Opacity-associated protein A
BED35_19995	COG0359	binds to the 23S rRNA
BED35_20000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BED35_20005	COG2965	DNA replication, synthesis of RNA primer
BED35_20010	COG0360	Binds together with S18 to 16S ribosomal RNA
BED35_20020	COG1073	alpha beta
BED35_20025	COG3650	response to hydrogen peroxide
BED35_20030	COG1960	acyl-CoA dehydrogenase activity
BED35_20040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED35_20045	COG0557	exoribonuclease II activity
BED35_20050	COG1959	2 iron, 2 sulfur cluster binding
BED35_20055	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BED35_20060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BED35_20065	COG0330	HflC and HflK could
BED35_20070	COG0330	HflC and HflK could
BED35_20075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BED35_20080	COG1923	regulation of RNA biosynthetic process
BED35_20085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BED35_20090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BED35_20095	COG0860	N-Acetylmuramoyl-L-alanine amidase
BED35_20100	COG0802	atpase or kinase
BED35_20105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BED35_20105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BED35_20110	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BED35_20125	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BED35_20130	COG1162	GTPase activity
BED35_20135	COG0688	phosphatidylethanolamine metabolic process
BED35_20140	COG3264	Mechanosensitive ion channel
BED35_20140	COG1511	domain protein
BED35_20145	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BED35_20150	COG1053	succinate dehydrogenase
BED35_20155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BED35_20160	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BED35_20165	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BED35_20175	COG2076	Multidrug Resistance protein
BED35_20185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BED35_20205	COG0459	protein refolding
BED35_20210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BED35_20225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BED35_20235	COG4232	protein-disulfide reductase activity
BED35_20240	COG1929	Belongs to the glycerate kinase type-1 family
BED35_20245	COG1309	transcriptional regulator
BED35_20255	COG1882	Formate acetyltransferase
BED35_20260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BED35_20265	COG0814	amino acid
BED35_20270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BED35_20280	COG3721	Heme iron utilization protein
BED35_20300	COG3720	iron ion transport
BED35_20305	COG4558	Periplasmic binding protein
BED35_20310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BED35_20315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BED35_20330	COG4774	siderophore transport
BED35_20345	COG2161	toxin-antitoxin pair type II binding
BED35_20355	COG4178	(ABC) transporter
BED35_20360	COG4771	TonB-dependent receptor
BED35_20365	COG3712	iron ion homeostasis
BED35_20380	COG0425	Belongs to the sulfur carrier protein TusA family
BED35_20385	COG2391	methyltransferase activity
BED35_20545	COG2197	response regulator
BED35_20550	COG1301	dicarboxylic acid transport
BED35_20555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BED35_20560	COG3162	membrane
BED35_20565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BED35_20610	COG0138	bifunctional purine biosynthesis protein purh
BED35_20615	COG0151	Belongs to the GarS family
BED35_20630	COG3068	Protein conserved in bacteria
BED35_20635	COG1515	deoxyribonuclease V activity
BED35_20640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BED35_20645	COG2816	NAD+ diphosphatase activity
BED35_20650	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BED35_20655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BED35_20665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BED35_20670	COG2104	thiamine diphosphate biosynthetic process
BED35_20675	COG2022	thiamine diphosphate biosynthetic process
BED35_20690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BED35_20695	COG0085	RNA polymerase activity
BED35_20705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BED35_20710	COG0081	regulation of translation
BED35_20715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BED35_20720	COG0250	Participates in transcription elongation, termination and antitermination
BED35_20725	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BED35_20730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BED35_20765	COG1072	(Pantothenic acid kinase))
BED35_20770	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BED35_20770	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BED35_20815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BED35_20820	COG1739	Uncharacterized protein family UPF0029
BED35_20825	COG0006	proline dipeptidase activity
BED35_20830	COG1250	3-hydroxyacyl-CoA dehydrogenase
BED35_20830	COG1024	Enoyl-CoA hydratase
BED35_20835	COG0183	Belongs to the thiolase family
BED35_20845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BED35_20865	COG0805	protein transport
BED35_20870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED35_20875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BED35_20880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BED35_20890	COG2226	methyltransferase
BED35_20905	COG1966	Carbon starvation protein
BED35_20915	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BED35_20920	COG0412	Dienelactone hydrolase
BED35_20925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BED35_20930	COG0583	DNA-binding transcription factor activity
BED35_20940	COG0679	Auxin Efflux Carrier
BED35_20945	COG0584	glycerophosphoryl diester phosphodiesterase
BED35_20950	COG3842	ATPase activity
BED35_20955	COG0395	ABC-type sugar transport system, permease component
BED35_20960	COG1175	transmembrane transport
BED35_20965	COG1653	transport
BED35_21000	COG0410	ABC transporter
BED35_21005	COG0411	ABC transporter
BED35_21010	COG4177	L-phenylalanine transmembrane transporter activity
BED35_21015	COG0559	Belongs to the binding-protein-dependent transport system permease family
BED35_21020	COG0683	leucine binding
BED35_21045	COG2177	Part of the ABC transporter FtsEX involved in
BED35_21050	COG2884	Cell division ATP-binding protein ftsE
BED35_21055	COG0552	protein localization to endoplasmic reticulum
BED35_21060	COG0742	ribosomal rna small subunit methyltransferase
BED35_21065	COG3776	membrane
BED35_21080	COG3714	YhhN family
BED35_21085	COG2217	Heavy metal translocating P-type atpase
BED35_21090	COG0425	Belongs to the sulfur carrier protein TusA family
BED35_21095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BED35_21105	COG0247	lactate metabolic process
BED35_21110	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BED35_21115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BED35_21120	COG2271	Major facilitator Superfamily
BED35_21125	COG0584	glycerophosphoryl diester phosphodiesterase
BED35_21130	COG0561	phosphatase activity
BED35_21135	COG2267	carboxylic ester hydrolase activity
BED35_21140	COG1280	lysine exporter protein (LysE YggA)
BED35_21145	COG1280	lysine exporter protein (LysE YggA)
BED35_21150	COG0514	ATP-dependent DNA helicase (RecQ)
BED35_21155	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BED35_21160	COG2050	protein possibly involved in aromatic compounds catabolism
BED35_21170	COG0598	Magnesium transport protein CorA
BED35_21175	COG5564	TIM-barrel signal transduction protein
BED35_21180	COG5441	Belongs to the UPF0261 family
BED35_21190	COG0210	DNA helicase
BED35_21195	COG1011	Hydrolase
BED35_21200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BED35_21205	COG3159	Protein conserved in bacteria
BED35_21210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BED35_21215	COG5567	small periplasmic lipoprotein
BED35_21220	COG1965	Belongs to the frataxin family
BED35_21230	COG3072	Adenylate cyclase
BED35_21235	COG0181	hydroxymethylbilane synthase activity
BED35_21240	COG1587	Uroporphyrinogen-III synthase
BED35_21245	COG2959	enzyme of heme biosynthesis
BED35_21250	COG3071	HemY protein
BED35_21295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BED35_21300	COG2244	polysaccharide biosynthetic process
BED35_21305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BED35_21310	COG0456	acetyltransferase
BED35_21315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BED35_21320	COG1088	dTDP-glucose 4,6-dehydratase activity
BED35_21325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BED35_21330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BED35_21335	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BED35_21340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BED35_21350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BED35_21355	COG3118	belongs to the thioredoxin family
BED35_21365	COG0248	Ppx GppA phosphatase
BED35_21380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BED35_21410	COG3177	Filamentation induced by cAMP protein fic
BED35_21445	COG0582	viral genome integration into host DNA
BED35_21450	COG1609	Transcriptional regulator
BED35_21450	COG2207	Transcriptional regulator
BED35_21455	COG4214	carbohydrate transport
BED35_21465	COG4213	ABC transporter substrate-binding protein
BED35_21470	COG2115	Belongs to the xylose isomerase family
BED35_21475	COG1070	Carbohydrate kinase
BED35_21480	COG3121	Chaperone
BED35_21495	COG3274	enterobacterial common antigen metabolic process
BED35_21505	COG3276	selenocysteine insertion sequence binding
BED35_21510	COG1921	L-seryl-tRNASec selenium transferase activity
BED35_21515	COG3058	Necessary for formate dehydrogenase activity
BED35_21520	COG2864	formate dehydrogenase
BED35_21525	COG0437	4 iron, 4 sulfur cluster binding
BED35_21530	COG0243	molybdopterin cofactor binding
BED35_21530	COG3383	formate dehydrogenase (NAD+) activity
BED35_21535	COG0243	molybdopterin cofactor binding
BED35_21535	COG3383	formate dehydrogenase (NAD+) activity
BED35_21540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BED35_21545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BED35_21550	COG0840	transmembrane signaling receptor activity
BED35_21555	COG2258	MOSC domain
BED35_21575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BED35_21585	COG3722	fumarate hydratase activity
BED35_21590	COG0246	Mannitol dehydrogenase
BED35_21595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BED35_21595	COG2213	PTS system mannitol-specific
BED35_21605	COG0751	glycine-tRNA ligase activity
BED35_21610	COG0752	glycyl-tRNA synthetase alpha subunit
BED35_21615	COG2818	Glycosylase
BED35_21620	COG0456	acetyltransferase
BED35_21650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BED35_21655	COG0366	Alpha amylase catalytic
BED35_21660	COG3977	Valine--pyruvate aminotransferase
BED35_21665	COG0569	domain protein
BED35_21665	COG2985	domain, Protein
BED35_21675	COG2814	Major facilitator Superfamily
BED35_21695	COG3152	Membrane
BED35_21705	COG0149	triose-phosphate isomerase activity
BED35_21715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BED35_21725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BED35_21730	COG3678	ATP-independent chaperone mediated protein folding
BED35_21735	COG0745	RESPONSE REGULATOR receiver
BED35_21740	COG2205	protein histidine kinase activity
BED35_21745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BED35_21745	COG2169	Transcriptional regulator
BED35_21750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BED35_21755	COG1045	serine acetyltransferase
BED35_21760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BED35_21765	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BED35_21770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BED35_21775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BED35_21780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BED35_21785	COG4942	peptidase
BED35_21790	COG2861	carbohydrate metabolic process
BED35_21805	COG1063	alcohol dehydrogenase
BED35_21810	COG0156	8-amino-7-oxononanoate synthase activity
BED35_21815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BED35_21820	COG0859	PFAM glycosyl transferase family 9
BED35_21825	COG0859	PFAM glycosyl transferase family 9
BED35_21830	COG1519	Transferase
BED35_21840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BED35_21845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BED35_21850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BED35_21855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BED35_21860	COG2003	Belongs to the UPF0758 family
BED35_21865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BED35_21870	COG0756	dUTP diphosphatase activity
BED35_21875	COG1309	transcriptional regulator
BED35_21880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BED35_21885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BED35_21890	COG1561	YicC-like family, N-terminal region
BED35_21895	COG0582	viral genome integration into host DNA
BED35_21915	COG3561	AntA/AntB antirepressor
BED35_21995	COG5001	Diguanylate cyclase
BED35_22000	COG1024	Enoyl-CoA hydratase
BED35_22005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BED35_22020	COG2860	membrane
BED35_22035	COG1758	RNA polymerase activity
BED35_22040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BED35_22045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BED35_22050	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BED35_22055	COG0786	glutamate:sodium symporter activity
BED35_22060	COG2233	PERMEase
BED35_22065	COG2982	Protein involved in outer membrane biogenesis
BED35_22080	COG3423	Transcriptional regulator
BED35_22085	COG0456	acetyltransferase
BED35_22090	COG1490	D-aminoacyl-tRNA deacylase activity
BED35_22095	COG1295	ribonuclease BN
BED35_22100	COG1011	Hydrolase
BED35_22110	COG0174	glutamine synthetase
BED35_22120	COG3852	Histidine kinase
BED35_22130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BED35_22135	COG3078	GTPase activator activity
BED35_22140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BED35_22145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED35_22145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BED35_22150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BED35_22155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BED35_22160	COG3084	Protein conserved in bacteria
BED35_22170	COG1763	Mo-molybdopterin cofactor biosynthetic process
BED35_22205	COG2186	Transcriptional regulator
BED35_22215	COG1609	Transcriptional regulator
BED35_22220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BED35_22225	COG1879	ABC-type sugar transport system periplasmic component
BED35_22230	COG1172	Belongs to the binding-protein-dependent transport system permease family
BED35_22240	COG1869	D-ribose catabolic process
BED35_22245	COG3158	transport of potassium into the cell
BED35_22250	COG0714	Associated with various cellular activities
BED35_22255	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BED35_22265	COG2502	aspartate--ammonia ligase
BED35_22270	COG1522	sequence-specific DNA binding
BED35_22275	COG0716	FMN binding
BED35_22280	COG0445	tRNA wobble uridine modification
BED35_22285	COG0357	Ribosomal RNA small subunit methyltransferase G
BED35_22290	COG3312	ion transport
BED35_22295	COG0356	it plays a direct role in the translocation of protons across the membrane
BED35_22305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BED35_22310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BED35_22315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BED35_22320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BED35_22325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BED35_22330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BED35_22335	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BED35_22340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BED35_22345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BED35_22350	COG0573	inorganic phosphate transmembrane transporter activity
BED35_22355	COG0581	inorganic phosphate transmembrane transporter activity
BED35_22365	COG0704	Plays a role in the regulation of phosphate uptake
BED35_22375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BED35_22385	COG0765	amino acid transport
BED35_22390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BED35_22395	COG2252	PERMEase
BED35_22405	COG4566	intracellular signal transduction
BED35_22415	COG0431	NADPH-dependent FMN reductase
BED35_22420	COG0840	transmembrane signaling receptor activity
BED35_22425	COG2011	ABC-type metal ion transport system permease component
BED35_22440	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BED35_22445	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BED35_22450	COG0706	membrane insertase activity
BED35_22460	COG0594	ribonuclease P activity
BED35_22465	COG0230	Belongs to the bacterial ribosomal protein bL34 family