locus-tag class description BED32_00020 ENOG4105D5G Transposase BED32_00105 ENOG4105D13 transposase BED32_00125 ENOG4106CQM replication BED32_00130 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) BED32_00160 ENOG4105CAU Arsenical resistance protein, ArsH BED32_00165 ENOG4105KBH arsR family transcriptional regulator BED32_00195 ENOG4105DWP Membrane BED32_00250 ENOG4105EZN Cobyrinic acid ac-diamide synthase BED32_00255 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB BED32_00460 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BED32_00465 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BED32_00470 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BED32_00475 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED32_00480 ENOG410667J hydrolase BED32_00490 ENOG4105C7B Threonine dehydratase BED32_00495 ENOG4105D99 atp gtp-binding protein BED32_00500 ENOG4105R2A (LipO)protein BED32_00515 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_00525 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BED32_00530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BED32_00540 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) BED32_00545 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BED32_00550 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BED32_00555 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BED32_00560 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BED32_00565 ENOG41063M6 Cell Division Protein BED32_00570 ENOG4105ETE Transcriptional regulator (LacI family BED32_00575 ENOG4105C25 Primosomal protein n' BED32_00580 ENOG4105VFB Binds the 23S rRNA (By similarity) BED32_00585 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BED32_00595 ENOG4105CFH Aspartokinase BED32_00600 ENOG4105SYT Methylenetetrahydrofolate reductase BED32_00605 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BED32_00615 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BED32_00620 ENOG4105CAS nag kinase BED32_00625 ENOG4105CH7 arginosuccinase BED32_00660 ENOG4107QZV Type I secretion membrane fusion protein BED32_00680 ENOG4105EHV domain protein BED32_00685 ENOG4105C5Q Transcriptional regulator BED32_00690 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BED32_00695 ENOG4105EJ2 Transcriptional regulator BED32_00700 ENOG4108Y73 Membrane BED32_00705 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) BED32_00715 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BED32_00755 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator BED32_00760 ENOG4105C2J ABC transporter BED32_00765 ENOG4107R9N ABC transporter BED32_00770 ENOG41062B0 ABC transporter, permease BED32_00775 ENOG4105CVI Transcriptional regulator BED32_00780 ENOG4108WFC UPF0438 protein yifE BED32_00785 ENOG4105C0P Mg chelatase subunit ChlI BED32_00795 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit BED32_00800 ENOG4105CM2 brancheD-chain amino acid aminotransferase BED32_00805 ENOG4105C01 Dihydroxy-acid dehydratase BED32_00810 ENOG4105C7B Threonine dehydratase BED32_00825 ENOG4105EMY transcriptional regulator BED32_00830 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BED32_00845 ENOG41060S4 immunity protein BED32_00855 ENOG4108VEV chaperone BED32_00875 ENOG4105GQR Chaperone BED32_00890 ENOG41060NJ transcriptional regulator BED32_00905 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures BED32_00915 ENOG4105D5G Transposase BED32_00925 ENOG4105CKT filamentous hemagglutinin BED32_00955 ENOG4105BZU Histidine kinase BED32_00960 ENOG4108KX4 response regulator BED32_00965 ENOG4105DIJ Phosphoethanolamine transferase BED32_00970 ENOG4108ZHJ Organic hydroperoxide resistance protein BED32_00975 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_00980 ENOG4105DEF Extracellular solute-binding protein, family 5 BED32_00985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BED32_00990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED32_00995 ENOG4105C3U ABC transporter BED32_01000 ENOG4108JQ7 (ABC) transporter BED32_01005 ENOG4105D1V cellulose synthase operon protein YhjU BED32_01010 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT BED32_01015 ENOG4105U74 cellulose biosynthesis protein BcsE BED32_01025 ENOG4105UTS cellulose synthase operon protein YhjQ BED32_01030 ENOG4107QZ7 Cellulose synthase catalytic subunit BED32_01035 ENOG4107EEX Cellulose synthase regulator protein BED32_01040 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) BED32_01045 ENOG4105EJG cellulose synthase BED32_01055 ENOG4105BZU Histidine kinase BED32_01060 ENOG4108PU9 oligogalacturonate-specific porin BED32_01075 ENOG4105CK2 sodium dicarboxylate symporter BED32_01080 ENOG4105CS0 peptidase BED32_01085 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BED32_01090 ENOG4105VSH 4-oxalocrotonate tautomerase BED32_01095 ENOG4105CMB EAL domain-containing protein BED32_01105 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) BED32_01110 ENOG4107H3J ribonuclease BED32_01120 ENOG4105DC8 reductase BED32_01125 ENOG4105D6S protein involved in catabolism of external DNA BED32_01130 ENOG4105DGW oligopeptidase A BED32_01135 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) BED32_01150 ENOG4108M6U Universal stress protein A BED32_01155 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_01160 ENOG4108V6B universal stress protein B BED32_01165 ENOG4105CJ3 phosphate transporter BED32_01170 ENOG4105CBX hi0933 family BED32_01210 ENOG4108BUD transposase BED32_01215 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BED32_01235 ENOG4105CK2 sodium dicarboxylate symporter BED32_01255 ENOG4105DJI Methylaspartate mutase, E subunit BED32_01270 ENOG4105JZC GHMP kinase BED32_01275 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED32_01280 ENOG41090KR LysR family transcriptional Regulator BED32_01285 ENOG4107GFK fumarate BED32_01295 ENOG4108HCJ Hydrolase BED32_01305 ENOG4105CR8 Transcriptional regulator BED32_01310 ENOG4105EQ0 Major Facilitator superfamily BED32_01315 ENOG4105C26 Dehydrogenase BED32_01320 ENOG4105DH8 myo-inositol catabolism BED32_01330 ENOG4105D7K pfkb domain protein BED32_01340 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BED32_01345 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BED32_01350 ENOG4105WCN acetyltransferase BED32_01355 ENOG4105C2I pirin domain protein BED32_01360 ENOG4105DIQ Transcriptional regulator BED32_01365 ENOG4105C6Z Gluconate BED32_01370 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BED32_01375 ENOG41076UM multiple antibiotic resistance (MarC)-related protein BED32_01380 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BED32_01385 ENOG4105C7K acetolactate synthase BED32_01400 ENOG4108HRK Histidine kinase BED32_01405 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BED32_01410 ENOG4108IUM Glycogen debranching enzyme BED32_01420 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BED32_01425 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BED32_01430 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BED32_01440 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_01445 ENOG4105E98 transcriptional regulator DeoR family BED32_01450 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) BED32_01465 ENOG41061ZR Transcriptional regulator BED32_01470 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BED32_01475 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BED32_01480 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BED32_01485 ENOG4105MJ2 Competence protein BED32_01490 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BED32_01495 ENOG4105RID UPF0379 protein yhcN BED32_01500 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_01505 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) BED32_01510 ENOG4105CE1 Ferrous iron transport protein b BED32_01515 ENOG4105XFK Ferrous iron transport protein A BED32_01520 ENOG4105BZM domain protein BED32_01545 ENOG4108RRZ Transcription elongation factor GreB BED32_01550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BED32_01555 ENOG4105E0F Histidine kinase BED32_01560 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BED32_01570 ENOG4105VEJ Heat shock protein BED32_01575 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 BED32_01580 ENOG4105DQY intracellular growth attenuator BED32_01585 ENOG4107RK2 ADP-ribose diphosphatase NudE BED32_01590 ENOG4108JQC penicillin-binding protein 1A BED32_01615 ENOG4105E4G Type IV pilus BED32_01620 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BED32_01640 ENOG4105DJV ribulose-phosphate 3-epimerase BED32_01650 ENOG4105C31 Tryptophanyl-tRNA synthetase BED32_01655 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED32_01665 ENOG4105WZK nitrite reductase NADPH small subunit BED32_01670 ENOG4107QZF nitrite reductase NADPH large subunit BED32_01675 ENOG4105DZC cytosine deaminase BED32_01680 ENOG4106DTQ Protein TsgA homolog BED32_01685 ENOG41060NJ transcriptional regulator BED32_01690 ENOG4105F8D glycoside hydrolase family 4 BED32_01695 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BED32_01700 ENOG4105D7A ATP-binding protein BED32_01710 ENOG4105C8Y Acetylornithine aminotransferase BED32_01725 ENOG4108UKZ OsmC family BED32_01730 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BED32_01735 ENOG4105YP7 UPF0270 protein BED32_01740 ENOG4105DNZ Alpha Beta Hydrolase BED32_01750 ENOG4105JAB phenazine biosynthesis protein, phzf family BED32_01755 ENOG4106FTQ Taurine ABC transporter, periplasmic BED32_01765 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BED32_01770 ENOG4105E2B Taurine dioxygenase BED32_01780 ENOG4105K64 Glycosyl transferase, family 2 BED32_01785 ENOG4105C5H ABC transporter BED32_01790 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BED32_01800 ENOG4105VKU nucleicacid-binding protein BED32_01805 ENOG4108YZY peptidylprolyl cis-trans isomerase BED32_01815 ENOG4108V1T peptidylprolyl cis-trans isomerase BED32_01820 ENOG4105WWK YheO domain protein BED32_01825 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BED32_01830 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BED32_01835 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BED32_01845 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BED32_01875 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BED32_01880 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BED32_01885 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BED32_01890 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BED32_01895 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BED32_01900 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BED32_01905 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BED32_01910 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BED32_01915 ENOG41083MP 50s ribosomal protein l29 BED32_01920 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BED32_01930 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BED32_01935 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BED32_01940 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BED32_01950 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BED32_01955 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BED32_01960 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BED32_01965 ENOG4105VPB 50S ribosomal protein L30 BED32_01970 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BED32_01975 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BED32_01980 ENOG41067V7 50S ribosomal protein L36 BED32_01990 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BED32_01995 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BED32_02000 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BED32_02005 ENOG4108ZT0 50S ribosomal protein l17 BED32_02010 ENOG4105VTS DnaJ-like, subfamily C BED32_02015 ENOG4105W1Y Transcriptional regulator BED32_02020 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system BED32_02030 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BED32_02035 ENOG4105C1A potassium transporter peripheral membrane BED32_02040 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BED32_02045 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BED32_02050 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BED32_02055 ENOG4105C79 DNA protecting protein DprA BED32_02065 ENOG4108WI1 Dna topoisomerase BED32_02070 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BED32_02075 ENOG4105E2X shikimate dehydrogenase BED32_02080 ENOG4108Z0R Transferase BED32_02110 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_02115 ENOG4105CVG Homoserine O-transsuccinylase BED32_02120 ENOG4107QP3 malate synthase g BED32_02125 ENOG4108I9X Isocitrate lyase BED32_02130 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) BED32_02135 ENOG41069M3 Transcriptional regulator BED32_02140 ENOG4105C3R Methionine synthase BED32_02155 ENOG4105C09 Bile acid BED32_02160 ENOG4105CFH Aspartokinase BED32_02165 ENOG4107QP8 phosphohexose isomerase BED32_02175 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_02180 ENOG4105EG2 ABC transporter, permease BED32_02190 ENOG4107FKK extracellular solute-binding protein family 1 BED32_02200 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BED32_02205 ENOG4107W52 maltose operon periplasmic protein BED32_02215 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BED32_02220 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BED32_02225 ENOG4105E55 glycerol-3-phosphate acyltransferase BED32_02230 ENOG41080IJ Diacylglycerol kinase BED32_02235 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BED32_02240 ENOG4105VDW Csbd family BED32_02245 ENOG4105MYN Zinc uptake regulation protein BED32_02250 ENOG4105EXC Acyl-transferase BED32_02255 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BED32_02260 ENOG4105P4Z Phage shock protein G BED32_02270 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BED32_02275 ENOG4105CDU Replicative dna helicase BED32_02285 ENOG4105CGF Aromatic amino acid aminotransferase BED32_02290 ENOG4105MSB protein, conserved in bacteria BED32_02295 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BED32_02305 ENOG4105CAF HipA N-terminal domain protein BED32_02320 ENOG4105C7N Xanthine uracil vitamin C permease BED32_02325 ENOG4105EEQ Na H antiporter BED32_02330 ENOG4105CMU LysR family (Transcriptional regulator BED32_02345 ENOG4105CDA abc transporter atp-binding protein BED32_02350 ENOG4105DRP amino acid AbC transporter BED32_02355 ENOG4105EZ7 amino acid ABC transporter BED32_02370 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_02375 ENOG4105D1S lipid A biosynthesis BED32_02380 ENOG4107QPK )-transporter BED32_02385 ENOG4105VEQ Cold shock protein BED32_02390 ENOG4105VEQ Cold shock protein BED32_02395 ENOG4108XTF Outer Membrane Lipoprotein BED32_02405 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BED32_02410 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BED32_02415 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BED32_02420 ENOG4108IA2 Sodium pantothenate symporter BED32_02425 ENOG4105RG0 Membrane BED32_02430 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BED32_02435 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BED32_02440 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BED32_02445 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) BED32_02455 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BED32_02460 ENOG41062P1 Diguanylate cyclase phosphodiesterase BED32_02465 ENOG4105DFF Rod shape-determining protein mreb BED32_02470 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BED32_02475 ENOG4105VQ7 Rod shape-determining protein MreD BED32_02485 ENOG4105C03 ribonuclease BED32_02490 ENOG4105QD6 exported protein BED32_02500 ENOG4105D1U peptidase U62 modulator of DNA gyrase BED32_02555 ENOG4105CR8 Transcriptional regulator BED32_02565 ENOG4105Y49 secretion protein, HlyD family BED32_02570 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) BED32_02585 ENOG4105UNR (Barnase) inhibitor BED32_02590 ENOG4105N42 UPF0307 protein BED32_02595 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED32_02625 ENOG4105DFE Dna adenine methylase BED32_02770 ENOG4105CMS peptidase U62, modulator of DNA gyrase BED32_02775 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_02780 ENOG4108XVM Cytochrome b(562) BED32_02785 ENOG4105NXH GreA GreB family elongation factor BED32_02815 ENOG41069H0 dihydroorotase EC 3.5.2.3 BED32_02835 ENOG4105EMD TRANSCRIPTIONal BED32_02840 ENOG41084S7 Plasmid maintenance system antidote protein BED32_02855 ENOG4105D4X repressor BED32_02865 ENOG4105CG3 alpha amylase, catalytic region BED32_02890 ENOG4105KME endoribonuclease L-psp BED32_02895 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) BED32_02900 ENOG4105CXT aspartate transcarbamylase BED32_02905 ENOG41080Z8 PHOSPHOCARRIER protein BED32_02910 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BED32_02915 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BED32_02920 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BED32_02925 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED32_02930 ENOG4108IUZ ABC transporter BED32_02935 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BED32_02940 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) BED32_02945 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BED32_02950 ENOG4105C2X Arabinose 5-phosphate isomerase BED32_02960 ENOG4105DHJ ABC, transporter BED32_02965 ENOG4105CY3 ABC transporter, permease BED32_02970 ENOG4107PE3 Mammalian cell entry related domain protein BED32_02975 ENOG4105E3I toluene tolerance BED32_02980 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane BED32_02985 ENOG4105VFK BolA family BED32_02990 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BED32_02995 ENOG4105C0H protease BED32_03000 ENOG4105C0H protease BED32_03005 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III BED32_03010 ENOG4105D6Z AFG1 family ATPase BED32_03015 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BED32_03020 ENOG4108UJD 30S ribosomal protein S9 BED32_03025 ENOG4107MKT Stringent starvation protein a BED32_03030 ENOG4105KB2 stringent starvation protein b BED32_03045 ENOG4105BZ8 glutamate synthase BED32_03050 ENOG4105CBC glutamate synthase BED32_03055 ENOG4105N5T Radical SAM Protein BED32_03060 ENOG4105BZU Histidine kinase BED32_03065 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BED32_03070 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BED32_03075 ENOG4105W4M Transport-associated protein BED32_03080 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BED32_03085 ENOG41082RQ UPF0102 protein BED32_03095 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BED32_03115 ENOG4108C33 Resolvase BED32_03150 ENOG4108VEV chaperone BED32_03155 ENOG4105CW0 outer membrane usher protein BED32_03165 ENOG4105EQ2 LysR family Transcriptional regulator BED32_03170 ENOG4107SET aldo keto reductase BED32_03175 ENOG4105DQ4 alcohol dehydrogenase BED32_03180 ENOG4108CNN domain protein BED32_03185 ENOG4105CWB LysR family transcriptional Regulator BED32_03190 ENOG4105CHF Glutathione S-transferase BED32_03195 ENOG4108VBZ doxx family BED32_03200 ENOG4105YJD BED32_03205 ENOG41090KG Inner membrane protein YqjE BED32_03210 ENOG4105NE1 Conserved Protein BED32_03225 ENOG4106W5V Membrane BED32_03245 ENOG4105D2H Uronic isomerase BED32_03250 ENOG4107QZW Altronate oxidoreductase BED32_03255 ENOG4105CTX dehydratase BED32_03260 ENOG4105P66 Membrane BED32_03265 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BED32_03270 ENOG4105DU1 integral membrane protein, terc BED32_03280 ENOG4105EE0 oxidoreductase BED32_03285 ENOG4108VKG metal-dependent hydrolase BED32_03305 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BED32_03310 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_03315 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BED32_03320 ENOG4108594 Permease of the drug metabolite transporter BED32_03325 ENOG4108YK4 Acid-resistance membrane protein BED32_03335 ENOG4105CVK Glutamate decarboxylase BED32_03340 ENOG4105E5D amino acid BED32_03345 ENOG4105CSV Glutaminase BED32_03355 ENOG4105D5G Transposase BED32_03360 ENOG4105C5Y PTS System BED32_03365 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BED32_03370 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) BED32_03375 ENOG4105D17 glycoside hydrolase, family 3 domain protein BED32_03385 ENOG4105EHZ conserved protein UCP016719 BED32_03395 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_03400 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED32_03405 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BED32_03410 ENOG4105VCC 30S ribosomal protein S21 BED32_03415 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BED32_03420 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BED32_03425 ENOG4107ZVW dihydroneopterin aldolase BED32_03430 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BED32_03435 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BED32_03440 ENOG4106MWK domain protein BED32_03445 ENOG4105I7R Adenylate cyclase BED32_03450 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BED32_03455 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BED32_03460 ENOG4105DVH amino acid BED32_03465 ENOG4105W0Z cytoplasmic protein BED32_03470 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BED32_03475 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BED32_03480 ENOG4106032 Glutathionylspermidine synthase BED32_03485 ENOG4105F1G UPF0441 protein BED32_03495 ENOG4105DFG type I secretion outer membrane protein BED32_03500 ENOG41087AY ADP-Ribose pyrophosphatase BED32_03505 ENOG4108SX3 cytoplasmic protein BED32_03510 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BED32_03515 ENOG4105IPS esterase BED32_03520 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED32_03525 ENOG4105JQN Transcriptional regulator BED32_03530 ENOG4105VRH Antibiotic biosynthesis monooxygenase BED32_03535 ENOG4105NF4 modulator of drug activity BED32_03540 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED32_03545 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BED32_03550 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) BED32_03560 ENOG4105CV8 reductase BED32_03565 ENOG4108I6A alcohol dehydrogenase BED32_03570 ENOG4105CF7 AraC family transcriptional regulator BED32_03575 ENOG4108K81 inner membrane protein YghB BED32_03580 ENOG4105C28 cystathionine BED32_03585 ENOG4105CWK Biopolymer transport protein, ExbB BED32_03590 ENOG4108ZZF transport protein (ExbD) BED32_03665 ENOG4105CF1 Alkylated DNA repair protein BED32_03670 ENOG4108IJF Heavy metal efflux pump, CzcA BED32_03680 ENOG4108RAV Conserved protein BED32_03720 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED32_03755 ENOG4105E0A ABC, transporter BED32_03760 ENOG4105TVJ transport system, permease BED32_03765 ENOG4105DQ5 transport system permease protein BED32_03770 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein BED32_03780 ENOG4105EXW epimerase dehydratase BED32_03785 ENOG4105C8Q Methyl-accepting chemotaxis BED32_03800 ENOG4105D00 flagellar biosynthetic protein flhB BED32_03805 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BED32_03810 ENOG4105VS8 Flagellar biosynthetic protein fliq BED32_03815 ENOG4105CN7 Flagellar biosynthetic protein FliP BED32_03820 ENOG4105DD5 Flagellar motor switch protein BED32_03830 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BED32_03835 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BED32_03855 ENOG4108JIR Flagellum-specific ATP synthase BED32_03880 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BED32_03885 ENOG4108ZC9 flagellar basal-body rod protein flgc BED32_03890 ENOG4105W00 Flagellar hook capping protein BED32_03895 ENOG4105BZE flagellar hook protein, FlgE BED32_03900 ENOG4108KPB Flagellar basal-body rod protein FlgF BED32_03905 ENOG4105CGA flagellar basal-body rod protein FlgG BED32_03915 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BED32_03950 ENOG4105I03 Flagellin BED32_03960 ENOG4105MQ3 flagellar protein FliS BED32_03985 ENOG4107RD7 Flagellar Motor Protein, MotA BED32_03995 ENOG4108XTF Outer Membrane Lipoprotein BED32_04000 ENOG4105E3S small subunit BED32_04005 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED32_04010 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit BED32_04015 ENOG4105DPX Hydrogenase, large subunit BED32_04020 ENOG4108USZ hydrogenase BED32_04025 ENOG4108WGS hydrogenase 2-specific chaperone BED32_04030 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BED32_04035 ENOG4107RSS Hydrogenase accessory protein HypB BED32_04040 ENOG41082MF Hydrogenase assembly chaperone hypC hupF BED32_04045 ENOG4105CQS hydrogenase expression formation protein HypD BED32_04050 ENOG4105C45 hydrogenase expression formation protein (HypE) BED32_04055 ENOG4105C8H hydrogenase maturation protein Hypf BED32_04060 ENOG4107R3N Filamentation induced by cAMP protein fic BED32_04065 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BED32_04085 ENOG4105ENT Efflux transporter rnd family, mfp subunit BED32_04100 ENOG4105CSH Transporter BED32_04115 ENOG4105EAM Na Pi-cotransporter BED32_04125 ENOG4105ETE Transcriptional regulator (LacI family BED32_04130 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_04145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED32_04175 ENOG4105CM4 permease protein BED32_04185 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BED32_04205 ENOG4105J12 Multidrug resistance protein mdtN BED32_04210 ENOG4108MI0 Resistance protein BED32_04220 ENOG4105CXN decarboxylase BED32_04225 ENOG4105D5Q Arginine ornithine antiporter BED32_04280 ENOG4105CXN decarboxylase BED32_04290 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BED32_04295 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BED32_04300 ENOG4105CEN a g-specific adenine glycosylase BED32_04305 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BED32_04310 ENOG41090ED Protein with unknown function (DUF469) BED32_04315 ENOG4105CSV Glutaminase BED32_04320 ENOG4105K33 Periplasmic Protein BED32_04325 ENOG4105CSA Coproporphyrinogen iii oxidase BED32_04330 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BED32_04335 ENOG4105VZ9 UPF0235 protein BED32_04340 ENOG4108VIA integral membrane protein BED32_04345 ENOG4105II7 pyrroline-5-carboxylate reductase BED32_04350 ENOG4105DFA alanine racemase domain protein BED32_04355 ENOG4105CZX twitching motility protein BED32_04365 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) BED32_04370 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BED32_04375 ENOG4108UJU UPF0301 protein BED32_04380 ENOG4105D7Z glutathione synthase BED32_04385 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BED32_04390 ENOG4105RWS endonuclease I BED32_04395 ENOG4105GPY SprT protein BED32_04400 ENOG41080HT Transcriptional regulator, arsr family BED32_04405 ENOG4105D5G Transposase BED32_04420 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BED32_04425 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BED32_04435 ENOG4108K0D peptidase, M48 BED32_04440 ENOG4105CV1 Transketolase (EC 2.2.1.1) BED32_04445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BED32_04450 ENOG4105BZA Phosphoglycerate kinase BED32_04455 ENOG4105D2N Aldolase BED32_04465 ENOG4105D64 Mechanosensitive ion channel BED32_04470 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_04475 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BED32_04480 ENOG4105MPN Membrane BED32_04485 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BED32_04490 ENOG4105E66 phosphoriboisomerase A BED32_04495 ENOG4108JQ1 Dehydrogenase BED32_04530 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BED32_04550 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BED32_04555 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BED32_04560 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BED32_04565 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BED32_04580 ENOG4108MXK alkaline phosphatase isozyme conversion BED32_04585 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED32_04590 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BED32_04595 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BED32_04600 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BED32_04605 ENOG4105N0Z inner membrane protein ygbE BED32_04610 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BED32_04620 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BED32_04625 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BED32_04630 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BED32_04635 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BED32_04640 ENOG4108K5P (LipO)protein BED32_04645 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BED32_04650 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BED32_04675 ENOG4106PG1 outer membrane usher protein BED32_04680 ENOG4108FZ9 Chaperone BED32_04690 ENOG4105UGQ Fimbrial BED32_04695 ENOG4105H8W Fimbrial protein BED32_04720 ENOG4108JJA ABC, transporter BED32_04725 ENOG4105DJY efflux transporter, rnd family, mfp subunit BED32_04735 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BED32_04740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED32_04755 ENOG4105CHR reductase BED32_04760 ENOG4105CIH Imidazole acetol-phosphate transaminase BED32_04765 ENOG4105CA0 peroxidase BED32_04775 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BED32_04780 ENOG4105YVS arsR family transcriptional regulator BED32_04785 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein BED32_04790 ENOG4105F3R pts system mannose fructose sorbose family iid BED32_04795 ENOG4105ETZ PTS System BED32_04805 ENOG4108XCU pts system BED32_04810 ENOG4105DKT Transcriptional regulator BED32_04835 ENOG4108IV0 ABC, transporter BED32_04840 ENOG4108IUZ ABC transporter BED32_04845 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BED32_04850 ENOG4105C32 Amino acid ABC transporter (Permease) BED32_04860 ENOG4107GFK fumarate BED32_04865 ENOG4107QY8 reductase BED32_04870 ENOG4105QAX Iron-sulfur BED32_04875 ENOG4107KGK dmso reductase anchor subunit BED32_04880 ENOG4108NEM leader-binding protein dmsD BED32_04885 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_04890 ENOG4108ISG Major Facilitator BED32_04900 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BED32_04905 ENOG4105Y3E Modulates RecA activity (By similarity) BED32_04910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BED32_04915 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BED32_04935 ENOG4107VXZ Hydrolase BED32_04945 ENOG4105D9M gamma-glutamylcysteine synthetase BED32_04950 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BED32_04955 ENOG4108JU6 CBS domain protein BED32_04960 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_04970 ENOG4106KVJ cytochrome C assembly protein BED32_04975 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BED32_04980 ENOG4105K5M 30s ribosomal protein S16 BED32_04985 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BED32_04990 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BED32_04995 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BED32_05005 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BED32_05010 ENOG4108NEV two component transcriptional regulator, LytTR family BED32_05015 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BED32_05020 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BED32_05025 ENOG4105CQC Prephenate dehydratase BED32_05030 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_05035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BED32_05040 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BED32_05045 ENOG4105C34 Pseudouridine synthase BED32_05050 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BED32_05060 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BED32_05065 ENOG4105D5G Transposase BED32_05070 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_05100 ENOG4105T42 (LipO)protein BED32_05105 ENOG4105JIM Phosphatidylserine synthase BED32_05110 ENOG4105CD5 CoA-binding domain protein BED32_05115 ENOG4106IUH DTW domain containing protein BED32_05120 ENOG4105K63 Thioredoxin BED32_05125 ENOG4105EIB trna rrna methyltransferase BED32_05130 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED32_05135 ENOG4105CW7 secretion protein, HlyD family BED32_05140 ENOG4105ETP RND efflux system, outer membrane lipoprotein BED32_05145 ENOG4105NTK Transcriptional repressor Mpra BED32_05150 ENOG4105ZED uncharacterized protein ygaH BED32_05155 ENOG4108UMN azlc family BED32_05160 ENOG4105EQ0 Major Facilitator superfamily BED32_05195 ENOG4105E5Q amino acid AbC transporter BED32_05200 ENOG4105E5Q amino acid AbC transporter BED32_05225 ENOG4105CHM Aminotransferase BED32_05230 ENOG4107R08 Integrase BED32_05285 ENOG41076J9 exonuclease VIII BED32_05365 ENOG4106CVF DNA replication protein BED32_05400 ENOG4105RWQ Protein of unknown function (DUF1364) BED32_05435 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED32_05600 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BED32_05605 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) BED32_05610 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BED32_05615 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BED32_05620 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BED32_05640 ENOG4107QPN acyl-Coa dehydrogenase BED32_05650 ENOG4105E7A Glutamine amidotransferase BED32_05655 ENOG4105F7V ErfK ybiS ycfS ynhG family protein BED32_05660 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED32_05665 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED32_05670 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED32_05675 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BED32_05685 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BED32_05690 ENOG4105CJ2 (LipO)protein BED32_05705 ENOG4105CPF Cell wall formation (By similarity) BED32_05710 ENOG4105WWK YheO domain protein BED32_05725 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BED32_05730 ENOG4105CIN aminoacyl-histidine dipeptidase BED32_05735 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BED32_05740 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_05745 ENOG4105V1F Fermentation respiration switch protein BED32_05750 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) BED32_05755 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BED32_05760 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BED32_05765 ENOG4105FDP GntR family transcriptional regulator BED32_05770 ENOG4105CI1 PTS System BED32_05775 ENOG4105F8D glycoside hydrolase family 4 BED32_05785 ENOG4105E2V Glycosyltransferase 36 BED32_05800 ENOG4105F2W methyltransferase BED32_05825 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BED32_05830 ENOG4105NBK UPF0345 protein BED32_05835 ENOG4105DH7 May be involved in recombination (By similarity) BED32_05840 ENOG4105DKQ ROK family BED32_05845 ENOG4105EYH Exonuclease BED32_05850 ENOG4107RH8 nuclease SbcCD subunit D BED32_05855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BED32_05860 ENOG4105BZU Histidine kinase BED32_05870 ENOG4105CWM branched-chain amino acid transport system II carrier protein BED32_05875 ENOG4105C85 amino acid BED32_05880 ENOG4107R28 alpha amylase, catalytic region BED32_05885 ENOG4105CHR reductase BED32_05895 ENOG41074AV Hok/gef family BED32_05900 ENOG4105D3R alkyl hydroperoxide reductase BED32_05905 ENOG4108ZYK Acyl carrier protein phosphodiesterase BED32_05910 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BED32_05920 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BED32_05925 ENOG4105VIE preprotein translocase, subunit YajC BED32_05930 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BED32_05935 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BED32_05950 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BED32_05955 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BED32_05960 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BED32_05965 ENOG4107YIM Involved in the transcription termination process (By similarity) BED32_05970 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BED32_05975 ENOG4108ZAI phosphatidylglycerophosphatase a BED32_05980 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_05985 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BED32_05990 ENOG4105CTB Polyprenyl synthetase BED32_06000 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BED32_06005 ENOG4107S0N DJ-1 family BED32_06010 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BED32_06015 ENOG4108VPT UPF0234 protein BED32_06020 ENOG4107RDB Major Facilitator BED32_06025 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BED32_06030 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) BED32_06035 ENOG4105CCU oxidase (Subunit III) BED32_06040 ENOG4105BZ9 Cytochrome C oxidase, subunit I BED32_06045 ENOG4105E2S oxidase) subunit II BED32_06050 ENOG4108NFH Sugar hydrolase BED32_06055 ENOG4105EYM Major Facilitator superfamily BED32_06060 ENOG4105IEY (LipO)protein BED32_06065 ENOG4105M85 Bola protein BED32_06075 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BED32_06080 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BED32_06085 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BED32_06090 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BED32_06095 ENOG4105K70 DNA-binding protein BED32_06100 ENOG4105EIN peptidylprolyl cis-trans isomerase BED32_06105 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BED32_06110 ENOG4108TGP Thioesterase superfamily protein BED32_06115 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BED32_06120 ENOG4108NFA extracellular solute-binding protein BED32_06125 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) BED32_06135 ENOG4108XM1 transcriptional regulator AsnC family BED32_06140 ENOG4105BZ1 (ABC) transporter BED32_06145 ENOG4105BZ1 (ABC) transporter BED32_06150 ENOG4108YZA Nitrogen regulatory protein pii BED32_06155 ENOG4105BZU Histidine kinase BED32_06160 ENOG4105C29 acyl-CoA thioesterase BED32_06165 ENOG4108MNP Glycoprotein polysaccharide metabolism BED32_06170 ENOG41080UX Methyltransferase BED32_06180 ENOG4105KF5 hemolysin expression-modulating protein BED32_06185 ENOG4108UKR Biofilm formation regulator YbaJ BED32_06195 ENOG4105DIK (ABC) transporter BED32_06200 ENOG4105CC5 ABC transporter BED32_06205 ENOG4105DSE periplasmic solute binding protein BED32_06210 ENOG4105YK5 50S ribosomal protein L36 BED32_06215 ENOG4105NRA 50s ribosomal protein l31 type b BED32_06220 ENOG4106M0N transport system permease protein BED32_06225 ENOG4105MUZ Protein of unknown function DUF2620 BED32_06230 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BED32_06235 ENOG4108626 Racemase BED32_06245 ENOG4105BZS acriflavin resistance protein BED32_06250 ENOG4105C1P efflux transporter, rnd family, mfp subunit BED32_06255 ENOG4108IG5 Transcriptional regulator BED32_06260 ENOG41090EX DsrE family BED32_06270 ENOG4106428 Protein of unknown function (DUF2496) BED32_06280 ENOG4105WD1 Membrane BED32_06285 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BED32_06290 ENOG4107QMP dna polymerase iii subunits gamma and tau BED32_06295 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BED32_06300 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BED32_06305 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BED32_06310 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BED32_06315 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BED32_06330 ENOG4108SHN Glycosyl transferase, family 2 BED32_06335 ENOG4105CG5 Glycosyl transferase (Group 1 BED32_06340 ENOG4107RJ7 Glycosyl transferase (Group 1 BED32_06345 ENOG4105ESV Glycosyl transferase, family 4 BED32_06360 ENOG4105CMR udp-glucose 4-epimerase BED32_06365 ENOG4107RE1 Inosine-guanosine kinase BED32_06370 ENOG4105CKD glutathione-regulated potassium-efflux system protein BED32_06375 ENOG4105EU0 Major facilitator Superfamily BED32_06390 ENOG4108Z66 YbaK ebsC protein BED32_06395 ENOG4105MBR gumn family BED32_06400 ENOG4105C59 p-type ATPase BED32_06405 ENOG4108Z6Z Transcriptional regulator BED32_06410 ENOG4105G5H Membrane BED32_06415 ENOG4107QX8 SPFH domain, Band 7 family protein BED32_06420 ENOG4107QR8 Thioredoxin BED32_06425 ENOG4105E1F short-chain dehydrogenase reductase BED32_06430 ENOG4108UJV acyl-CoA thioesterase i BED32_06435 ENOG4108I0Y (ABC) transporter BED32_06440 ENOG4105CV6 ABC transporter, permease BED32_06445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BED32_06450 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BED32_06455 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BED32_06460 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BED32_06465 ENOG4105C8N cysteinyl-tRNA synthetase BED32_06470 ENOG4105WQ3 Rna-binding protein BED32_06475 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BED32_06485 ENOG4108KU3 Integrase BED32_06535 ENOG41076J9 exonuclease VIII BED32_06600 ENOG4106CVF DNA replication protein BED32_06635 ENOG4105RWQ Protein of unknown function (DUF1364) BED32_06685 ENOG4105MPK DNA polymerase III subunit theta BED32_06760 ENOG4105TKZ Tail Sheath BED32_06820 ENOG4105EXC Acyl-transferase BED32_06825 ENOG4108KU3 Integrase BED32_06950 ENOG4105CDU Replicative dna helicase BED32_07000 ENOG4108R1E Serine threonine protein phosphatase 1 BED32_07040 ENOG4105KUS lysozyme BED32_07045 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED32_07205 ENOG4105DFP Integrase BED32_07210 ENOG4105DFP Integrase BED32_07215 ENOG4105DFP Integrase BED32_07230 ENOG4107R3N Filamentation induced by cAMP protein fic BED32_07285 ENOG4105KT5 UmuD protein BED32_07305 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_07315 ENOG4105EZE Cupin 4 family protein BED32_07325 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BED32_07330 ENOG4108JJ7 ABC transporter BED32_07345 ENOG4108R1E Serine threonine protein phosphatase 1 BED32_07365 ENOG4105VEQ Cold shock protein BED32_07370 ENOG4107Z6W Protein CrcB homolog BED32_07375 ENOG4105BZU Histidine kinase BED32_07380 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) BED32_07385 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BED32_07390 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BED32_07395 ENOG4108Z43 UPF0250 protein BED32_07400 ENOG4105DZ1 carboxypeptidase BED32_07405 ENOG4105K6T rare lipoprotein A BED32_07410 ENOG4105CNI cell division protein FtsW BED32_07415 ENOG4105CJN penicillin-binding protein BED32_07425 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BED32_07430 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BED32_07435 ENOG4105DJF DNA polymerase III, delta' subunit BED32_07440 ENOG4108U2H Rare lipoprotein B BED32_07445 ENOG4105C8T Leucyl-tRNA synthetase BED32_07450 ENOG4107PAI alpha helical protein BED32_07455 ENOG4105CDA abc transporter atp-binding protein BED32_07460 ENOG4105DRP amino acid AbC transporter BED32_07465 ENOG4105EAD ABC transporter BED32_07470 ENOG4107RP9 extracellular solute-binding protein, family 3 BED32_07480 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BED32_07485 ENOG4108JU5 Magnesium and cobalt efflux protein BED32_07495 ENOG4105C9A Phoh family BED32_07500 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BED32_07505 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BED32_07540 ENOG4105CAQ asparagine synthetase BED32_07545 ENOG4105D4U had-superfamily hydrolase, subfamily iia BED32_07550 ENOG4105E2R ROK family BED32_07555 ENOG4105CE4 GlcNAc 6-P deacetylase BED32_07560 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BED32_07565 ENOG4105CI1 PTS System BED32_07570 ENOG4105CX6 glutaminyL-tRNA synthetase BED32_07580 ENOG4105GX6 (LipO)protein BED32_07590 ENOG41090R7 Ferric uptake BED32_07595 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BED32_07600 ENOG4105C8Q Methyl-accepting chemotaxis BED32_07605 ENOG4105NNH LexA regulated protein BED32_07610 ENOG4105EV9 Alpha Beta Hydrolase BED32_07620 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BED32_07635 ENOG4105EEX Two component transcriptional regulator (Winged helix family BED32_07640 ENOG4105C08 Histidine kinase BED32_07645 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BED32_07650 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BED32_07655 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BED32_07665 ENOG4105XIQ Protein of unknown function (DUF2517) BED32_07675 ENOG4108RC6 RTX toxin BED32_07685 ENOG4107SEY Conserved Protein BED32_07690 ENOG4105CVP deoxyribo-dipyrimidine photolyase BED32_07695 ENOG4107RF4 Phosphodiesterase BED32_07700 ENOG4107QNR UPF0135 protein BED32_07705 ENOG4105P4J Allophanate hydrolase, subunit 1 BED32_07710 ENOG4107R7A Allophanate hydrolase subunit 2 BED32_07715 ENOG4105E7W lamb ycsf family protein BED32_07730 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BED32_07735 ENOG4105BZN citrate synthase BED32_07740 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BED32_07745 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BED32_07755 ENOG4105E33 succinate dehydrogenase BED32_07760 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BED32_07765 ENOG4105C7S Dehydrogenase BED32_07770 ENOG4105CMV Succinyl-CoA synthetase subunit beta BED32_07775 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BED32_07780 ENOG4105CGH 5'-nucleotidase BED32_07785 ENOG4105C4M (Ubiquinol oxidase) subunit I BED32_07790 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BED32_07800 ENOG4105KJB cyd operon protein YbgE BED32_07805 ENOG4107YD3 Thioesterase BED32_07810 ENOG4105E02 MotA TolQ exbB proton channel BED32_07815 ENOG4105M8F Biopolymer transport protein exbD tolR BED32_07820 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA BED32_07820 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA BED32_07825 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BED32_07830 ENOG4105KCK Peptidoglycan-associated lipoprotein BED32_07835 ENOG4105UFD tol-pal system protein YbgF BED32_07860 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BED32_07865 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BED32_07870 ENOG4105PGM cation diffusion facilitator family transporter BED32_07875 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BED32_07880 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BED32_07905 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BED32_07910 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BED32_07915 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BED32_07920 ENOG4105CMR udp-glucose 4-epimerase BED32_07930 ENOG4105DKW ABC transporter BED32_07935 ENOG4105F4R Transcriptional regulator mode BED32_07940 ENOG410680R Protein of unknown function (DUF2592) BED32_07945 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BED32_07950 ENOG4105E0C molybdate abc transporter BED32_07960 ENOG4108K4B hydrolase BED32_07965 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BED32_07975 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BED32_07980 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BED32_07985 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BED32_07990 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BED32_08000 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BED32_08005 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BED32_08010 ENOG4105CHW UPF0052 protein BED32_08015 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BED32_08020 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BED32_08025 ENOG4105M00 molybdopterin converting factor, subunit 1 BED32_08030 ENOG4108ZAF Molybdopterin BED32_08035 ENOG4105HFZ Membrane BED32_08040 ENOG4107QWP ABC-2 type transporter BED32_08045 ENOG4107QWP ABC-2 type transporter BED32_08050 ENOG4105CJ1 ABC, transporter BED32_08055 ENOG4105D0S secretion protein (HlyD BED32_08060 ENOG4107MVR Transcriptional regulator BED32_08065 ENOG4105C1J atp-dependent rna helicase BED32_08070 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BED32_08080 ENOG4105CJW magnesium transporter BED32_08085 ENOG41061WM D-Alanyl-D-Alanine BED32_08090 ENOG4105CXG d-lactate dehydrogenase BED32_08100 ENOG4105N1F Hnh endonuclease BED32_08110 ENOG4105Y3U Transglycosylase-associated protein BED32_08120 ENOG4105EHI Phosphonate ABC transporter, periplasmic BED32_08135 ENOG4108W15 Protein of unknown function (DUF1456) BED32_08145 ENOG4105C32 Amino acid ABC transporter (Permease) BED32_08150 ENOG4105CNN ABC, transporter BED32_08155 ENOG4105D5T phosphonate abc transporter BED32_08160 ENOG4108IV0 ABC, transporter BED32_08165 ENOG4105KHC sulfurtransferase BED32_08180 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system BED32_08190 ENOG4108IJ8 ABC transporter BED32_08195 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component BED32_08210 ENOG4105HEI LysR family (Transcriptional regulator BED32_08220 ENOG4105FDR Membrane BED32_08235 ENOG4105DVT helicase BED32_08240 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BED32_08245 ENOG4108MTB glycosyl transferase family BED32_08265 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) BED32_08270 ENOG4107SDU Methyl-accepting chemotaxis BED32_08275 ENOG4105CDA abc transporter atp-binding protein BED32_08280 ENOG4105E5Q amino acid AbC transporter BED32_08285 ENOG4107R0W ABC transporter BED32_08290 ENOG4105KSC Transcriptional regulator, TraR DksA family BED32_08295 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BED32_08300 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) BED32_08335 ENOG4108T1M outer membrane protein x BED32_08355 ENOG4105C5H ABC transporter BED32_08360 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_08365 ENOG4105D06 uba thif-type nad fad binding protein BED32_08370 ENOG4105CVM Molybdenum cofactor synthesis domain protein BED32_08385 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED32_08415 ENOG4105EGI Transcriptional regulator BED32_08420 ENOG4105CBP Major Facilitator BED32_08425 ENOG4105EUJ GTP cyclohydrolase i BED32_08430 ENOG4105DHF Membrane BED32_08435 ENOG41060NJ transcriptional regulator BED32_08450 ENOG4107SDZ Galactoside transport system permease protein mglC BED32_08455 ENOG4108JUA Transcriptional regulator BED32_08465 ENOG4108RC0 Electron transport protein BED32_08470 ENOG4108MG9 hydrogenase 3 maturation protease BED32_08475 ENOG4105I6X formate hydrogenlyase maturation BED32_08480 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit BED32_08490 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED32_08495 ENOG4108JPZ Monovalent cation H antiporter subunit D BED32_08500 ENOG4107WQX hydrogenase 4 membrane subunit BED32_08505 ENOG4105D65 subunit l BED32_08510 ENOG4107TDF Formate hydrogenlyase subunit 4 BED32_08515 ENOG4108JPZ Monovalent cation H antiporter subunit D BED32_08520 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) BED32_08525 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BED32_08535 ENOG4107GZ4 SanA protein BED32_08540 ENOG4107R1I NAD-dependent malic enzyme BED32_08555 ENOG41067MG lrgb family BED32_08560 ENOG4105VAW lrga family BED32_08565 ENOG4105E5W Transporter BED32_08585 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BED32_08590 ENOG4105D1F ATP-binding protein BED32_08595 ENOG4105DBI uridine monophosphokinase BED32_08605 ENOG4108GAE asmA family BED32_08610 ENOG4105CEE C4-dicarboxylate transporter BED32_08615 ENOG4105EE5 Membrane protein terC BED32_08650 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BED32_08660 ENOG4107RGC Glycosyl transferase, family 2 BED32_08675 ENOG4105D5G Transposase BED32_08700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BED32_08705 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BED32_08710 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BED32_08715 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BED32_08720 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BED32_08725 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BED32_08730 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BED32_08735 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BED32_08740 ENOG4105CIH Imidazole acetol-phosphate transaminase BED32_08750 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BED32_08755 ENOG4108535 NAD dependent epimerase/dehydratase family BED32_08760 ENOG4105CNN ABC, transporter BED32_08765 ENOG4105C2J ABC transporter BED32_08770 ENOG4107SCQ Iron-containing alcohol dehydrogenase BED32_08780 ENOG4105CUB amino acid BED32_08785 ENOG4105CJB Exodeoxyribonuclease I BED32_08790 ENOG4105E4E Thioester reductase domain-containing protein BED32_08795 ENOG4105DR8 Membrane BED32_08800 ENOG41090HJ UPF0265 protein BED32_08810 ENOG4105CNN ABC, transporter BED32_08815 ENOG4105C2J ABC transporter BED32_08820 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BED32_08825 ENOG4105JZC GHMP kinase BED32_08830 ENOG4107QZB decarboxylase BED32_08835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BED32_08840 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BED32_08845 ENOG4105KTW ethanolamine utilization protein BED32_08850 ENOG4105M3W utilization protein BED32_08860 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BED32_08870 ENOG4108EKI Dehydrogenase BED32_08880 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml BED32_08890 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) BED32_08900 ENOG4105KNY Microcompartments protein BED32_08910 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit BED32_08915 ENOG4108ZFT Dehydratase small subunit BED32_08920 ENOG4105YCI dehydratase medium subunit BED32_08925 ENOG4105DMB glycerol dehydratase BED32_08930 ENOG4105EHR propanediol utilization protein pduB BED32_08935 ENOG4105KNY Microcompartments protein BED32_08940 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BED32_08945 ENOG4107XVH Transcriptional regulator BED32_08950 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BED32_08960 ENOG41081F0 Precorrin-8x methylmutase BED32_08965 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) BED32_08970 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase BED32_08975 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase BED32_08980 ENOG4105CIA precorrin-4 C(11)-methyltransferase BED32_08985 ENOG4108P62 biosynthesis protein (CbiG) BED32_08990 ENOG4105E4R Precorrin-3B C17-methyltransferase BED32_08995 ENOG4105QUC reductase BED32_09000 ENOG4107PPM cobalt chelatase BED32_09005 ENOG4105DVK Precorrin-2 c20-methyltransferase BED32_09010 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) BED32_09020 ENOG4108V4M Cobalt abc transporter BED32_09030 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BED32_09040 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BED32_09045 ENOG4108TGR phosphatase BED32_09050 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BED32_09095 ENOG4105CS6 Rhs element vgr protein BED32_09120 ENOG4105CDH Citrulline--aspartate ligase BED32_09125 ENOG4105UQX Mate efflux family protein BED32_09135 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BED32_09140 ENOG410667J hydrolase BED32_09145 ENOG4105E98 transcriptional regulator DeoR family BED32_09150 ENOG4107S1E Beta-lactamase BED32_09155 ENOG4107R88 Chemotaxis protein (CheV) BED32_09185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED32_09190 ENOG4107RCV ABC transporter, permease BED32_09195 ENOG4105C4Y ABC transporter BED32_09200 ENOG4105CXY transporter BED32_09205 ENOG4105BZU Histidine kinase BED32_09210 ENOG4108KX4 response regulator BED32_09215 ENOG4106YYS transcriptional regulatory protein BED32_09220 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BED32_09235 ENOG4105DUA (citrate (pro-3S)-lyase ligase BED32_09240 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) BED32_09245 ENOG4105CI0 Citrate lyase BED32_09250 ENOG4105CHY citrate lyase, alpha BED32_09255 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BED32_09260 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BED32_09265 ENOG4107QPK )-transporter BED32_09280 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BED32_09290 ENOG4108TSE Transferase BED32_09300 ENOG4105C54 Major Facilitator superfamily BED32_09305 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BED32_09310 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme BED32_09315 ENOG4105D3G Pseudouridine synthase BED32_09330 ENOG4108MQF Chaperone BED32_09360 ENOG4108Q9V regulatoR BED32_09370 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) BED32_09380 ENOG4105CMG Carbohydrate kinase BED32_09405 ENOG4108S1B Periplasmic chaperone protein BED32_09410 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_09415 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BED32_09425 ENOG41061EV selenium-binding protein YdfZ BED32_09440 ENOG4105GSJ Inner membrane protein ylaC BED32_09450 ENOG4105D5G Transposase BED32_09455 ENOG4105CNT hydrolase family 2 BED32_09460 ENOG4105ETE Transcriptional regulator (LacI family BED32_09465 ENOG4105VEQ Cold shock protein BED32_09470 ENOG4105VZF DsrB protein BED32_09475 ENOG4105C8Q Methyl-accepting chemotaxis BED32_09490 ENOG4105KT7 mgtC SapB transporter BED32_09495 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BED32_09500 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BED32_09505 ENOG4108VA4 Universal stress protein BED32_09510 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) BED32_09515 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region BED32_09520 ENOG4107RD7 Flagellar Motor Protein, MotA BED32_09530 ENOG4105CBS Chea signal transduction histidine kinase BED32_09535 ENOG4108V3W Chemotaxis protein, CheW BED32_09540 ENOG4105C8Q Methyl-accepting chemotaxis BED32_09545 ENOG4105C8Q Methyl-accepting chemotaxis BED32_09550 ENOG4105BZU Histidine kinase BED32_09560 ENOG4108VYJ response regulator receiver protein BED32_09565 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) BED32_09570 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin BED32_09575 ENOG4105D00 flagellar biosynthetic protein flhB BED32_09580 ENOG4105D7B Flagellar biosynthesis protein flha BED32_09585 ENOG4105W13 flagellar protein BED32_09595 ENOG4105QVD Flagella synthesis protein FlgN BED32_09600 ENOG4105M9M anti-sigma28 factor FlgM BED32_09605 ENOG4105CKS Flagella basal body P-ring formation protein flgA BED32_09615 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BED32_09635 ENOG4105ZTC transcriptional activator, Ogr delta BED32_09710 ENOG4105EXG Transcriptional regulator BED32_09730 ENOG4105HRS Antitermination protein BED32_09745 ENOG4105KUS lysozyme BED32_09755 ENOG4108Q2J Inner membrane protein YebE BED32_09765 ENOG41066YJ Beta-lactamase BED32_09770 ENOG4105C3G gtp-binding protein BED32_09780 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BED32_09785 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria BED32_09795 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BED32_09805 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BED32_09810 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BED32_09815 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BED32_09820 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BED32_09825 ENOG4108YY7 Invasion gene expression up-regulator SirB BED32_09830 ENOG41063JG Transcriptional regulator BED32_09835 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BED32_09840 ENOG4105CHH sulfate transporter BED32_09845 ENOG4105BZU Histidine kinase BED32_09870 ENOG4107SSZ Phosphatase BED32_09875 ENOG4107XHZ cytoplasmic chaperone TorD family protein BED32_09880 ENOG4105F3T (LipO)protein BED32_09885 ENOG4105EV4 Multidrug resistance protein mdtH BED32_09900 ENOG4105D9U N-acetyltransferase BED32_09910 ENOG4105EP9 oxidoreductase BED32_09915 ENOG4105CJR Integral membrane protein (MviN BED32_09920 ENOG4105EWV Sodium calcium exchanger membrane region BED32_09930 ENOG4105F27 Major Facilitator BED32_09935 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_09945 ENOG4105BZU Histidine kinase BED32_09950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BED32_09955 ENOG4105C4M (Ubiquinol oxidase) subunit I BED32_09960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED32_09970 ENOG4105F4X arginine BED32_09980 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) BED32_09985 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) BED32_09990 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_10015 ENOG4105CI2 imidazolone-5-propionate hydrolase BED32_10020 ENOG4105CZE histidine utilization repressor BED32_10025 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BED32_10055 ENOG4108K5P (LipO)protein BED32_10060 ENOG4105D2N Aldolase BED32_10065 ENOG4105E70 isomerase BED32_10070 ENOG4108YTN IIa component BED32_10075 ENOG4105F3R pts system mannose fructose sorbose family iid BED32_10085 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB BED32_10090 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of BED32_10095 ENOG4105E98 transcriptional regulator DeoR family BED32_10105 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_10115 ENOG4105FE9 pseudouridine synthase BED32_10120 ENOG4105D6U Sodium Glutamate Symporter BED32_10130 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_10135 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_10140 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BED32_10145 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) BED32_10150 ENOG4105WJG Glutathione BED32_10155 ENOG41081XQ Conserved Protein BED32_10160 ENOG4105D3W isochorismatase BED32_10165 ENOG4105C9M aspartyl-trna synthetase BED32_10170 ENOG4108TIT dATP pyrophosphohydrolase BED32_10175 ENOG4105CDY transcriptional regulatory protein BED32_10180 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BED32_10185 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BED32_10190 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BED32_10195 ENOG4105DUX Transporter BED32_10200 ENOG4105FAV ABC, transporter BED32_10205 ENOG4105FDK ABC transporter BED32_10210 ENOG4105NXV High-affinity zinc uptake system protein BED32_10215 ENOG4105DR5 peptidase BED32_10220 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BED32_10235 ENOG4105CA9 Pyruvate kinase BED32_10240 ENOG4106KNT transcriptional regulator BED32_10245 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BED32_10250 ENOG4108UHU Aldolase BED32_10255 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) BED32_10265 ENOG4105M4H endoribonuclease L-psp BED32_10270 ENOG4105DVT helicase BED32_10275 ENOG41072GX Peptidase M22 Glycoprotease BED32_10285 ENOG4105CEY Amp-dependent synthetase and ligase BED32_10290 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BED32_10295 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BED32_10300 ENOG4107QMS site-determining protein BED32_10305 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BED32_10315 ENOG4105VNG YcgL domain-containing protein BED32_10320 ENOG4105CVE Lytic murein transglycosylase BED32_10325 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BED32_10330 ENOG4108ZZ3 UPF0260 protein BED32_10355 ENOG4105D64 Mechanosensitive ion channel BED32_10360 ENOG4108SHQ Glutathione S-transferase BED32_10380 ENOG4105WT8 Protein of unknown function (DUF1480) BED32_10410 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED32_10420 ENOG4105DY2 Paraquat-inducible protein b BED32_10425 ENOG4105H2K paraquat-inducible protein a BED32_10430 ENOG4108ZGC gaf domain protein BED32_10440 ENOG4105CN1 protease BED32_10445 ENOG4105D0M Protease HtpX homolog BED32_10460 ENOG4105CAZ oligogalacturonide lyase BED32_10470 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BED32_10480 ENOG4107K5X Membrane-bound metal-dependent hydrolase BED32_10490 ENOG4108PU9 oligogalacturonate-specific porin BED32_10495 ENOG4105WEM extracellular solute-binding protein BED32_10500 ENOG4108IJ9 (ABC) transporter BED32_10505 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BED32_10510 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BED32_10515 ENOG41061NF Pectate lyase BED32_10520 ENOG4105CHR reductase BED32_10525 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BED32_10530 ENOG4105M5J Cupin 2, conserved barrel domain protein BED32_10535 ENOG4105D5G Transposase BED32_10540 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BED32_10545 ENOG4107PN8 YfeABCD locus regulator BED32_10550 ENOG4105DEQ transcriptional regulator BED32_10555 ENOG4105CYC Transferase BED32_10560 ENOG4108M7F enoyl-CoA hydratase isomerase BED32_10565 ENOG4105DJT lAO AO transport system ATPase BED32_10575 ENOG4105FGM Fructosamine kinase BED32_10580 ENOG4105CC5 ABC transporter BED32_10585 ENOG4105CC5 ABC transporter BED32_10590 ENOG4105DIK (ABC) transporter BED32_10595 ENOG4105DSE periplasmic solute binding protein BED32_10600 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BED32_10605 ENOG41082NP Multiple antibiotic resistance BED32_10630 ENOG4108UQV Membrane BED32_10635 ENOG41087WU BED32_10640 ENOG4105C22 threonyL-tRNA synthetase BED32_10645 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BED32_10650 ENOG41082NX 50s ribosomal protein l35 BED32_10655 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BED32_10660 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BED32_10670 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BED32_10685 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) BED32_10690 ENOG4108V06 Glutathione peroxidase BED32_10695 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) BED32_10700 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BED32_10705 ENOG4105CKK Glycosyl transferase, family 2 BED32_10710 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BED32_10715 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BED32_10720 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BED32_10725 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BED32_10730 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BED32_10735 ENOG4108QBX (LipO)protein BED32_10760 ENOG4107ENK receptor BED32_10765 ENOG4107F3C Hemin uptake protein BED32_10770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BED32_10775 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BED32_10780 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BED32_10790 ENOG4105IPI Membrane BED32_10795 ENOG4105CQB FAD linked oxidase domain protein BED32_10800 ENOG4105KA0 thioesterase Superfamily protein BED32_10805 ENOG4108Z4V iron-sulfur cluster assembly BED32_10810 ENOG4105DIW FeS assembly protein SUFB BED32_10815 ENOG4105C3K feS assembly ATPase SufC BED32_10820 ENOG4105JRK feS assembly protein SufD BED32_10830 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BED32_10835 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BED32_10840 ENOG4105KMX major outer membrane lipoprotein BED32_10845 ENOG4105CA9 Pyruvate kinase BED32_10865 ENOG4108R6K riboflavin synthase, subunit alpha BED32_10870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BED32_10875 ENOG4105CZQ inner membrane transport protein YdhC BED32_10880 ENOG4105F52 Transcriptional regulator BED32_10885 ENOG4105ETE Transcriptional regulator (LacI family BED32_10890 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BED32_10895 ENOG4105K4H Nlp p60 protein BED32_10900 ENOG4105M2J Glutaredoxin BED32_10905 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BED32_10915 ENOG4108UYE Lactoylglutathione lyase BED32_10925 ENOG4108WUH Transcriptional regulator, TetR family BED32_10930 ENOG4105DIJ Phosphoethanolamine transferase BED32_10935 ENOG4105XZD Fe-S protein BED32_10940 ENOG4107RGM aldo keto reductase BED32_10945 ENOG4105DSW Fusaric acid resistance protein BED32_10960 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) BED32_10965 ENOG4108XTF Outer Membrane Lipoprotein BED32_10970 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BED32_10975 ENOG410642K Lysozyme inhibitor BED32_10980 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BED32_10995 ENOG4108K3A Glutathione S-transferase BED32_11000 ENOG4108ZR5 Conserved Protein BED32_11005 ENOG41069YE inner membrane protein yohC BED32_11015 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_11020 ENOG4105DUX Transporter BED32_11025 ENOG4105DUM transcriptional regulator, lysR family BED32_11030 ENOG4105Q4T oxidoreductase BED32_11040 ENOG4108JQ2 peptide transport system atp-binding protein BED32_11045 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BED32_11050 ENOG4108EU3 peptide transport system, permease BED32_11055 ENOG4108I5W peptide transport system, permease protein BED32_11060 ENOG4108HIY periplasmic BED32_11075 ENOG4105E51 psp operon transcriptional activator BED32_11080 ENOG41087YS Phage shock protein A BED32_11085 ENOG4105YYT phage shock protein B BED32_11090 ENOG4105FM1 phage shock protein C BED32_11100 ENOG4105CM6 amino acid regulated cytosolic protein BED32_11105 ENOG4106K28 UPF0283 membrane protein BED32_11125 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BED32_11130 ENOG4107S8C mandelate racemase muconate lactonizing BED32_11135 ENOG4105KXI murein peptide amidase A BED32_11140 ENOG4107QSI ABC, transporter BED32_11145 ENOG4107RX3 Mg2 transporter protein cora family protein BED32_11150 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BED32_11155 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BED32_11170 ENOG4105KT7 mgtC SapB transporter BED32_11180 ENOG4105C5I Dehydrogenase BED32_11185 ENOG4107H52 Dicarboxylate transport BED32_11190 ENOG410689M (LipO)protein BED32_11195 ENOG4105WXT Conserved Protein BED32_11200 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BED32_11205 ENOG4105CQ7 ATP-dependent helicase BED32_11220 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap BED32_11230 ENOG4105CTD carboxy-peptidase BED32_11235 ENOG4105JJR Histidine kinase BED32_11240 ENOG4107EXC regulatoR BED32_11250 ENOG4105D5Q Arginine ornithine antiporter BED32_11255 ENOG4105C5D exported protein BED32_11265 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BED32_11270 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BED32_11275 ENOG4105Q9Y Universal stress protein BED32_11280 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BED32_11285 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BED32_11300 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) BED32_11305 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BED32_11330 ENOG4105PAD Hydrolase BED32_11335 ENOG4105M71 acetolactate synthase 1 regulatory subunit BED32_11340 ENOG4105C7K acetolactate synthase BED32_11350 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BED32_11390 ENOG4106NZI LysR family Transcriptional regulator BED32_11395 ENOG4105D94 Major Facilitator Superfamily BED32_11410 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) BED32_11420 ENOG4105C9Q fumarate hydratase class II BED32_11425 ENOG4105EIP mannose-6-phosphate isomerase BED32_11430 ENOG4106J39 exported protein BED32_11440 ENOG4107P2S Transcriptional regulator BED32_11445 ENOG4105CI1 PTS System BED32_11450 ENOG4105C87 Aminotransferase class I and II BED32_11455 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BED32_11460 ENOG4105DHU Bile acid BED32_11465 ENOG4105D9R oxidoreductase BED32_11485 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator BED32_11495 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BED32_11505 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BED32_11515 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BED32_11530 ENOG4105M9B inner membrane protein ydgK BED32_11535 ENOG4105DGN Electron transport complex BED32_11545 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) BED32_11555 ENOG4105UEI Transcriptional Regulator AraC Family BED32_11560 ENOG4105D6A Electron transport complex BED32_11565 ENOG4108UQQ Electron transport complex BED32_11575 ENOG4105CSM endonuclease III BED32_11675 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED32_11740 ENOG4106CVF DNA replication protein BED32_11820 ENOG41076J9 exonuclease VIII BED32_11840 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) BED32_11845 ENOG4105D22 carbon starvation protein BED32_11850 ENOG4105VCD cytoplasmic protein BED32_11855 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BED32_11860 ENOG4105N2W Transcriptional regulator BED32_11870 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BED32_11875 ENOG41061RM osmotically inducible lipoprotein BED32_11880 ENOG4108ZJT translation initiation factor, Sui1 BED32_11885 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BED32_11890 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction BED32_11895 ENOG4105DKK Benzoate BED32_11900 ENOG4108JCI Transcriptional regulator BED32_11910 ENOG4105CFV Tetratricopeptide repeat protein BED32_11915 ENOG4105Q4A inner membrane protein yciS BED32_11920 ENOG4105EYK Phosphatidylglycerophosphatase B BED32_11925 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BED32_11930 ENOG4107QM5 aconitate hydratase BED32_11940 ENOG4107R11 Transcriptional regulator BED32_11945 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BED32_11950 ENOG4105RKX Protein of unknown function (DUF2498) BED32_11955 ENOG4105ERU peptidase BED32_11960 ENOG4105UBK short-chain dehydrogenase reductase BED32_11965 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BED32_11975 ENOG4105FE9 pseudouridine synthase BED32_11980 ENOG4107RTD sua5 ycio yrdc ywlc family protein BED32_11985 ENOG4105DB7 PHP domain protein BED32_11995 ENOG4105DDQ anthranilate synthase BED32_12005 ENOG4105DK0 Indole-3-glycerol phosphate synthase BED32_12010 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BED32_12015 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BED32_12025 ENOG4105EIF outer membrane protein W BED32_12030 ENOG4105PI0 Ferredoxin BED32_12035 ENOG4108S3I UPF0259 membrane protein BED32_12045 ENOG4107835 probably involved in intracellular septation (By similarity) BED32_12050 ENOG4105NAU thioesterase Superfamily protein BED32_12055 ENOG410822N TonB family BED32_12060 ENOG4105K9H YciI-like protein BED32_12075 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BED32_12080 ENOG4108W5H UPF0263 protein BED32_12085 ENOG4108JQ7 (ABC) transporter BED32_12090 ENOG4105C3U ABC transporter BED32_12095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED32_12100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BED32_12105 ENOG4107QSI ABC, transporter BED32_12110 ENOG4107QSI ABC, transporter BED32_12115 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BED32_12120 ENOG4108EKI Dehydrogenase BED32_12125 ENOG4107104 thymidine kinase BED32_12140 ENOG4105C6Y Udp-glucose 6-dehydrogenase BED32_12145 ENOG4105I93 response regulator BED32_12150 ENOG4105D78 K07001 NTE family protein BED32_12160 ENOG4105K5B UPF0225 protein BED32_12165 ENOG4105CIY formyltetrahydrofolate deformylase BED32_12180 ENOG4105SKE transcriptional Regulator LysR family BED32_12185 ENOG4105CGK Exodeoxyribonuclease III BED32_12190 ENOG4105M6F mutator MutT protein BED32_12195 ENOG4105MTM Protein of unknown function (DUF1496) BED32_12200 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BED32_12210 ENOG41069NU Nitroreductase BED32_12215 ENOG4105D07 Signal peptide peptidase, SppA BED32_12220 ENOG4105HDK L-asparaginase BED32_12225 ENOG4108RWI nicotinamidase BED32_12240 ENOG4105E0X reductase BED32_12250 ENOG4105DSB aldose 1-epimerase BED32_12255 ENOG4105GNX MltA-interacting MipA family protein BED32_12260 ENOG4105CYN Serine protein kinase BED32_12265 ENOG4106AKX UPF0229 protein BED32_12280 ENOG4105HEI LysR family (Transcriptional regulator BED32_12285 ENOG4105EUB pirin domain protein BED32_12290 ENOG4105BZU Histidine kinase BED32_12300 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BED32_12305 ENOG4105MWK D-amino acid dehydrogenase, small subunit BED32_12310 ENOG4105ED1 spovr family BED32_12315 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BED32_12320 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BED32_12325 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BED32_12345 ENOG4106N3A copper homeostasis protein cutc BED32_12350 ENOG4106ZCM YecM protein BED32_12355 ENOG4105C75 arginyL-tRNA synthetase BED32_12365 ENOG4105D5M phosphate starvation-inducible protein BED32_12380 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD BED32_12385 ENOG4105CND Glycosyl transferase, family 2 BED32_12400 ENOG4105H1N peptidase, M24 BED32_12410 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BED32_12435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED32_12445 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BED32_12460 ENOG4107SJW iron permease, FTR1 BED32_12475 ENOG4105CSV Glutaminase BED32_12480 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BED32_12485 ENOG4105FB2 class II Aldolase BED32_12490 ENOG4105G63 Type III effector Hrp-dependent BED32_12495 ENOG4105MVE transcriptional regulator BED32_12500 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BED32_12505 ENOG4108MRH transcriptional regulatory protein BED32_12515 ENOG4105C85 amino acid BED32_12530 ENOG4106UW1 Major Facilitator superfamily BED32_12535 ENOG4108HCJ Hydrolase BED32_12545 ENOG4105D5G Transposase BED32_12550 ENOG4108WF3 methyltransferase BED32_12555 ENOG4105D5G Transposase BED32_12600 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED32_12605 ENOG4105NKT exported protein BED32_12610 ENOG4108PNC copper resistance BED32_12615 ENOG4105FXM Copper resistance protein BED32_12620 ENOG41090A1 ferritin BED32_12625 ENOG4105MPK DNA polymerase III subunit theta BED32_12635 ENOG4105UMD exodeoxyribonuclease X BED32_12640 ENOG4105CUG Oligopeptidase b BED32_12650 ENOG4105N5Z UPF0267 protein BED32_12655 ENOG4105X2V dna damage-inducible protein BED32_12660 ENOG4105C1J atp-dependent rna helicase BED32_12665 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BED32_12670 ENOG4105X5C UPF0181 protein BED32_12680 ENOG4105P8F nudix hydrolase BED32_12685 ENOG4105EJQ L-serine dehydratase BED32_12690 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_12695 ENOG4105EE5 Membrane protein terC BED32_12700 ENOG4108EQA pts system BED32_12705 ENOG4105ETZ PTS System BED32_12710 ENOG4105F3R pts system mannose fructose sorbose family iid BED32_12715 ENOG4108NK4 UPF0266 membrane protein BED32_12720 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) BED32_12730 ENOG4105BZU Histidine kinase BED32_12740 ENOG4105DHI Methyltransferase BED32_12745 ENOG4105CJN penicillin-binding protein BED32_12750 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BED32_12755 ENOG4105VEQ Cold shock protein BED32_12760 ENOG410610J Protein of unknown function (DUF2627) BED32_12765 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) BED32_12785 ENOG41064PC BED32_12790 ENOG4105TIK BED32_12795 ENOG4105N4N Protein of unknown function (DUF2766) BED32_12810 ENOG4105D5Q Arginine ornithine antiporter BED32_12820 ENOG4105BZ1 (ABC) transporter BED32_12850 ENOG4105XXV Acid-resistance protein BED32_12855 ENOG4105VTN Protein of unknown function (DUF1311) BED32_12865 ENOG4105DWP Membrane BED32_12880 ENOG4105KVH Transcriptional regulator BED32_12885 ENOG4105ECR NmrA family BED32_12890 ENOG4108IQK o-acetylhomoserine BED32_12900 ENOG4105KT5 UmuD protein BED32_12905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BED32_12910 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BED32_12920 ENOG4106NDP Transcriptional regulator BED32_12925 ENOG4108HKT sucrose-6-phosphate hydrolase BED32_12930 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BED32_12945 ENOG4108HMX isocitrate dehydrogenase (NADP) BED32_12975 ENOG4108HMX isocitrate dehydrogenase (NADP) BED32_12980 ENOG4108R99 pseudouridine synthase BED32_12990 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BED32_12995 ENOG41075W9 High frequency lysogenization protein HflD homolog BED32_13000 ENOG4107QTF adenylosuccinate lyase BED32_13010 ENOG4105XJC Two component transcriptional regulator (Winged helix family BED32_13030 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BED32_13040 ENOG4105D60 lipoprotein releasing system transmembrane protein BED32_13050 ENOG4105D60 lipoprotein releasing system transmembrane protein BED32_13055 ENOG4108JA2 transcriptioN-repair coupling factor BED32_13060 ENOG4107MBR 17 kDa surface antigen BED32_13065 ENOG4105CEP NADH dehydrogenase BED32_13070 ENOG4105D0Y UPF0227 protein BED32_13075 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BED32_13080 ENOG4108RUM thiamine kinase BED32_13085 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) BED32_13090 ENOG41090DQ Lipoprotein BED32_13095 ENOG4105K59 histidine triad (HIT) protein BED32_13100 ENOG4105F9E Shikimate 5-dehydrogenase BED32_13110 ENOG4105C4X radical SAM domain protein BED32_13120 ENOG4108JJA ABC, transporter BED32_13130 ENOG4105CI1 PTS System BED32_13135 ENOG4105F8V Hydrolase, tatD family BED32_13140 ENOG4107QRG dna polymerase iii BED32_13145 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BED32_13150 ENOG4105HHA aminodeoxychorismate lyase BED32_13155 ENOG4105YAZ 4-amino-4-deoxychorismate lyase BED32_13160 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED32_13170 ENOG4105CHR reductase BED32_13175 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BED32_13180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BED32_13185 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BED32_13190 ENOG4105VGS 50s ribosomal protein l32 BED32_13195 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BED32_13205 ENOG4105EI2 Pseudouridine synthase BED32_13210 ENOG4107QQB Ribonuclease E BED32_13215 ENOG41067V3 Antibiotic biosynthesis monooxygenase BED32_13220 ENOG4105EKE dihydroorotase BED32_13230 ENOG4105PVA Biofilm formation regulatory protein BssS BED32_13245 ENOG4105DSF transport protein BED32_13250 ENOG4105C72 UPF0176 protein BED32_13260 ENOG4106WHD Tetrathionate reductase BED32_13265 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED32_13275 ENOG4108ZXC Two component transcriptional regulator, luxr family BED32_13280 ENOG4105D1S lipid A biosynthesis BED32_13290 ENOG4108VGI doxx family BED32_13300 ENOG4105C6X Major Facilitator BED32_13305 ENOG4105DUX Transporter BED32_13310 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) BED32_13315 ENOG4105DJ9 glucan biosynthesis protein BED32_13330 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_13335 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) BED32_13345 ENOG4107YC3 synthase BED32_13350 ENOG4105VJY transcriptional regulator BED32_13355 ENOG4108W0S formate-dependent nitrite reductase complex BED32_13365 ENOG4107QX9 Thiol disulfide interChange protein BED32_13375 ENOG4105DVI reductase, NrfD BED32_13380 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED32_13385 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit BED32_13390 ENOG4105EAU Plays a role in nitrite reduction (By similarity) BED32_13400 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BED32_13405 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 BED32_13420 ENOG4105DR4 Methyltransferase BED32_13425 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) BED32_13430 ENOG4105K4P CoA-binding domain protein BED32_13435 ENOG4108Q67 UPF0319 protein BED32_13440 ENOG4108Z5K methylglyoxal synthase BED32_13445 ENOG41088T4 Helicase IV BED32_13450 ENOG410901E Membrane BED32_13455 ENOG4105EM2 membrane BED32_13460 ENOG4108RZ1 DNA transformation protein BED32_13470 ENOG4105UYK outer membrane protein a BED32_13475 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) BED32_13480 ENOG4105DAN ATP-dependent protease BED32_13485 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BED32_13495 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED32_13500 ENOG4108Q2G (LipO)protein BED32_13505 ENOG4105DY2 Paraquat-inducible protein b BED32_13510 ENOG4105F1S paraquat-inducible protein a BED32_13515 ENOG4105C5H ABC transporter BED32_13520 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BED32_13525 ENOG4105QVC MOSC domain-containing protein BED32_13530 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) BED32_13535 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BED32_13540 ENOG4105CD8 aminopeptidase N BED32_13545 ENOG4107RH7 Nicotinate phosphoribosyltransferase BED32_13550 ENOG4105C5S asparaginyl-tRNA synthetase BED32_13560 ENOG4105CGF Aromatic amino acid aminotransferase BED32_13570 ENOG4105C5X domain protein BED32_13575 ENOG4105EAQ (twin-arginine translocation) pathway signal BED32_13580 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BED32_13585 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) BED32_13590 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BED32_13595 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) BED32_13600 ENOG4106371 Methyltransferase BED32_13605 ENOG4107S90 membrAne BED32_13610 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups BED32_13615 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BED32_13620 ENOG4105W49 UPF0434 protein BED32_13625 ENOG4105VEQ Cold shock protein BED32_13630 ENOG4105VEQ Cold shock protein BED32_13635 ENOG4105E32 cytoplasmic protein BED32_13640 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BED32_13650 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BED32_13655 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BED32_13660 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BED32_13665 ENOG4105CAT Cytidine monophosphate kinase BED32_13670 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BED32_13675 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BED32_13680 ENOG4107VMU Membrane BED32_13685 ENOG4105HDK L-asparaginase BED32_13690 ENOG4105DDY UPF0142 protein ycaO BED32_13695 ENOG4105TMB Formate nitrite transporter BED32_13700 ENOG4105C6N Formate acetyltransferase BED32_13705 ENOG4105F1A Pyruvate formate-lyase BED32_13710 ENOG4108ISG Major Facilitator BED32_13715 ENOG4105D5G Transposase BED32_13725 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_13730 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BED32_13735 ENOG4105D1H recombination factor protein RarA BED32_13740 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BED32_13745 ENOG4105CNU cell division protein FtsK BED32_13750 ENOG4105EW9 transcriptional regulator AsnC family BED32_13755 ENOG4105C3M thioredoxin reductase BED32_13760 ENOG4108JJ9 ABC, transporter BED32_13765 ENOG4108JJ8 (ABC) transporter BED32_13770 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BED32_13775 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BED32_13780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BED32_13785 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BED32_13790 ENOG4105VEQ Cold shock protein BED32_13800 ENOG4105DJY efflux transporter, rnd family, mfp subunit BED32_13805 ENOG4108MJ5 VirK protein BED32_13810 ENOG4105CPB ATP-dependent endonuclease of the OLD family BED32_13815 ENOG4105DWU Membrane BED32_13820 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BED32_13825 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BED32_13830 ENOG4105C7K acetolactate synthase BED32_13840 ENOG4105C5W Aldolase BED32_13845 ENOG4105CGD Nad-dependent epimerase dehydratase BED32_13850 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BED32_13855 ENOG41064MM (LipO)protein BED32_13860 ENOG4105E5Z arginine transporter ATP-binding subunit BED32_13865 ENOG4106PMH Extracellular solute-binding protein family 3 BED32_13870 ENOG4105GBT ABC transporter BED32_13875 ENOG4105DMR ABC, transporter BED32_13880 ENOG4106TNF Periplasmic binding protein BED32_13885 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BED32_13890 ENOG4105RBQ inner membrane protein ybjO BED32_13895 ENOG4105D38 putrescine abc transporter BED32_13900 ENOG4105F38 ABC transporter, permease BED32_13905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED32_13910 ENOG4107RUE extracellular solute-binding protein family 1 BED32_13915 ENOG4108RMJ sensory transduction regulator BED32_13920 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress BED32_13925 ENOG41090BQ Glutaredoxin BED32_13930 ENOG4105D0C transport protein BED32_13940 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BED32_13945 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BED32_13950 ENOG4107FB0 transcriptional regulator DeoR family BED32_13955 ENOG4105C44 Serine transporter BED32_13960 ENOG4105EJQ L-serine dehydratase BED32_13965 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_13970 ENOG4105DZ1 carboxypeptidase BED32_13980 ENOG4105C28 cystathionine BED32_13985 ENOG4108UMI ABC transporter, permease BED32_13995 ENOG4105D01 (LipO)protein BED32_14010 ENOG4108TGY Glutathione S-transferase BED32_14015 ENOG4105D05 Receptor BED32_14025 ENOG4105EHG Permease protein BED32_14030 ENOG4108IQI permease BED32_14035 ENOG4105DUM transcriptional regulator, lysR family BED32_14050 ENOG4105HMI Membrane BED32_14055 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BED32_14060 ENOG4108D1K outer membrane usher protein BED32_14065 ENOG4108UIF Chaperone BED32_14080 ENOG4108SGD regulatory protein BED32_14085 ENOG4105DM4 PTS System BED32_14090 ENOG4105DE4 1-phosphofructokinase BED32_14095 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BED32_14105 ENOG4105CUW cytochrome C-TYPE protein BED32_14110 ENOG4107QY8 reductase BED32_14125 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BED32_14130 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BED32_14140 ENOG4105DEI Mannitol dehydrogenase BED32_14145 ENOG4107YCY Transcriptional regulator BED32_14155 ENOG4105CKI cobalamin synthesis protein BED32_14160 ENOG41076MN Phosphoesterase, PA-phosphatase related BED32_14165 ENOG4107TT5 NLP P60 protein BED32_14175 ENOG4105CXC rtn protein BED32_14180 ENOG4105E43 Extracellular solute-binding protein, family 5 BED32_14185 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BED32_14190 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BED32_14195 ENOG4108JQ5 ABC transporter BED32_14200 ENOG4105HG6 BED32_14205 ENOG4105C2C drug resistance transporter, Bcr CflA BED32_14210 ENOG4105I08 Pseudouridine synthase BED32_14215 ENOG4105CFI type iii restriction protein res subunit BED32_14220 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BED32_14225 ENOG4106V8H Nucleoid-associated protein BED32_14230 ENOG4105PAN UPF0352 protein BED32_14235 ENOG4105E68 Sulfatase BED32_14255 ENOG4105D5G Transposase BED32_14285 ENOG4108UHE carbonic anhydrase BED32_14290 ENOG4105CS2 ec 3.2.1.21 BED32_14295 ENOG4105C5Y PTS System BED32_14300 ENOG4108Q3X Transcriptional regulator BED32_14320 ENOG4105HRS Antitermination protein BED32_14330 ENOG4105Y50 Virulence Protein BED32_14340 ENOG4105C8Q Methyl-accepting chemotaxis BED32_14350 ENOG4105CT4 transporter BED32_14355 ENOG4107R6D beta-lactam binding protein AmpH BED32_14375 ENOG4105C42 Type I secretion membrane fusion protein (HlyD BED32_14385 ENOG4106UW1 Major Facilitator superfamily BED32_14390 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC BED32_14395 ENOG41068CG regulatoR BED32_14400 ENOG4105BZU Histidine kinase BED32_14405 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BED32_14410 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BED32_14415 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BED32_14420 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BED32_14430 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) BED32_14450 ENOG4105E0U tyrosine-specific transport protein BED32_14455 ENOG4108UII YfaZ family BED32_14460 ENOG4105CH6 catalase BED32_14465 ENOG4105CEY Amp-dependent synthetase and ligase BED32_14470 ENOG4105DNI Converts SHCHC to OSB (By similarity) BED32_14475 ENOG4108IPT Naphthoate synthase BED32_14480 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BED32_14485 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BED32_14490 ENOG4105E4F Isochorismate synthase BED32_14495 ENOG4105TNS Conserved Protein BED32_14500 ENOG4105C01 Dihydroxy-acid dehydratase BED32_14505 ENOG41090KN UPF0303 protein BED32_14515 ENOG4105C5I Dehydrogenase BED32_14520 ENOG4105K2J Transcriptional regulator BED32_14525 ENOG4105CHR reductase BED32_14530 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BED32_14540 ENOG4108UQ5 membrane protein YcdZ BED32_14550 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED32_14555 ENOG4105C8S subunit m BED32_14560 ENOG4105D65 subunit l BED32_14565 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED32_14570 ENOG4107UFS subunit j BED32_14575 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED32_14580 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BED32_14585 ENOG4108IEH NADH dehydrogenase subunit g BED32_14590 ENOG4107QIZ NADH dehydrogenase BED32_14595 ENOG4105GKE subunit e BED32_14600 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED32_14605 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BED32_14610 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BED32_14615 ENOG4107NQ8 LysR family Transcriptional regulator BED32_14620 ENOG4105CHM Aminotransferase BED32_14625 ENOG4105DK2 UPF0207 protein BED32_14630 ENOG4107QWE )-transporter BED32_14640 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 BED32_14645 ENOG4105XWI UPF0304 protein BED32_14650 ENOG4105PQ6 UPF0208 membrane protein BED32_14660 ENOG4105C6K Malic enzyme BED32_14665 ENOG4107P2S Transcriptional regulator BED32_14670 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BED32_14680 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BED32_14685 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_14690 ENOG4105PTV Nudix Hydrolase BED32_14705 ENOG4105ECP epimerase BED32_14715 ENOG4108JEH abc transporter atp-binding protein BED32_14720 ENOG4106YG3 ABC transporter BED32_14725 ENOG4105DSP amino acid AbC transporter BED32_14730 ENOG4105E89 ABC transporter BED32_14735 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BED32_14740 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BED32_14745 ENOG4105E96 Colicin v production protein BED32_14750 ENOG4108S3P Sporulation domain protein BED32_14755 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BED32_14760 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BED32_14765 ENOG4105DQR SNARE associated Golgi BED32_14775 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BED32_14780 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BED32_14800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED32_14805 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BED32_14815 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BED32_14825 ENOG4106WZ1 flagella biosynthesis regulator BED32_14830 ENOG4105F4P )-transporter BED32_14835 ENOG4105D6F Phosphatase BED32_14840 ENOG4105ETE Transcriptional regulator (LacI family BED32_14850 ENOG4105CK1 PTS System BED32_14855 ENOG4105CS2 ec 3.2.1.21 BED32_14860 ENOG4105VCP PTS System BED32_14880 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BED32_14885 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BED32_14890 ENOG4105MH2 YfcL protein BED32_14895 ENOG4108BPE -transporting atpase BED32_14900 ENOG4105EJ9 Membrane BED32_14905 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BED32_14910 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BED32_14915 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BED32_14920 ENOG4108DG9 Smr protein MutS2 BED32_14925 ENOG4108BY2 phosphohistidine phosphatase BED32_14930 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BED32_14935 ENOG4105CHU acetyl-coa acetyltransferase BED32_14940 ENOG4105KZW UPF0381 protein BED32_14945 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BED32_14950 ENOG410903C (LipO)protein BED32_14955 ENOG4105KWW Biogenesis protein BED32_14960 ENOG4108M1T Cytochrome c-type biogenesis protein BED32_14965 ENOG4107QX9 Thiol disulfide interChange protein BED32_14970 ENOG4105DA4 cytochrome c-type biogenesis protein BED32_14975 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BED32_14980 ENOG4105X3C heme exporter protein BED32_14985 ENOG41060IM Heme exporter protein BED32_14990 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BED32_15000 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_15005 ENOG4105S64 Formate nitrite transporter BED32_15015 ENOG4105DFP Integrase BED32_15075 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BED32_15080 ENOG4105NTW Transcriptional regulator BED32_15090 ENOG4105CS2 ec 3.2.1.21 BED32_15095 ENOG4105C5Y PTS System BED32_15100 ENOG4105DDV Transcriptional regulator (LacI family BED32_15105 ENOG4108YYC ycei family BED32_15110 ENOG4105DS1 cytochrome b561 BED32_15135 ENOG4105DHJ ABC, transporter BED32_15160 ENOG4105CUB amino acid BED32_15165 ENOG4105CVE Lytic murein transglycosylase BED32_15180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED32_15195 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin BED32_15200 ENOG4108VKM cytochrome b561 BED32_15205 ENOG4105CHM Aminotransferase BED32_15215 ENOG41072TH Protein of unknown function (DUF1479) BED32_15225 ENOG4105DY9 regulatoR BED32_15235 ENOG4105CHC glucokinase (EC 2.7.1.2) BED32_15245 ENOG4105C5Q Transcriptional regulator BED32_15250 ENOG4107RA9 decarboxylase BED32_15255 ENOG4105CPC Aldo Keto reductase BED32_15265 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BED32_15270 ENOG4105D9N nucleoside BED32_15300 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BED32_15325 ENOG4105VRT cytoplasmic protein BED32_15330 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BED32_15345 ENOG4105C6T cysteine synthase BED32_15350 ENOG4105KZ7 phosphocarrier protein hpr BED32_15355 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BED32_15360 ENOG4105C5Y PTS System BED32_15365 ENOG4105E0F Histidine kinase BED32_15370 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED32_15375 ENOG4105DJY efflux transporter, rnd family, mfp subunit BED32_15385 ENOG4105C6T cysteine synthase BED32_15395 ENOG4105ECW sulfate abc transporter BED32_15400 ENOG4108I5D sulfate abc transporter BED32_15405 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein BED32_15415 ENOG4105QEK Transcriptional regulator BED32_15420 ENOG4108R66 Conserved Protein BED32_15440 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_15445 ENOG4105EZR dyp-type peroxidase family protein BED32_15450 ENOG4105E7K (LipO)protein BED32_15455 ENOG4105H4F exported protein BED32_15460 ENOG4108R6G acetyltransferase BED32_15465 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BED32_15470 ENOG4108UPT UPF0178 protein BED32_15480 ENOG4105C6K Malic enzyme BED32_15485 ENOG4107VIJ nudix hydrolase BED32_15495 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) BED32_15500 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BED32_15505 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase BED32_15515 ENOG4105WH1 Two component transcriptional regulator luxr family BED32_15525 ENOG4105BZS acriflavin resistance protein BED32_15545 ENOG4105KUZ arsenate reductase BED32_15550 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BED32_15560 ENOG4105XYK UPF0370 protein BED32_15575 ENOG4108T1M outer membrane protein x BED32_15590 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_15595 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 BED32_15600 ENOG4106KED esterase YpfH BED32_15615 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) BED32_15620 ENOG4108VMM UPF0756 membrane protein BED32_15625 ENOG4105CGZ zinc metallopeptidase BED32_15630 ENOG4105C8V SAICAR synthetase BED32_15635 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BED32_15640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BED32_15645 ENOG4105RH4 Glycine cleavage system transcriptional repressor BED32_15650 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BED32_15655 ENOG4105C02 permease BED32_15660 ENOG4105ERG peptidase m48, ste24p BED32_15665 ENOG4105K89 arsenate reductase BED32_15670 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BED32_15675 ENOG4105C2W permease BED32_15680 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BED32_15690 ENOG4108V3E phosphoribosylglycinamide formyltransferase BED32_15695 ENOG4108MK9 spermidine N(1)-acetyltransferase BED32_15700 ENOG4108C80 FliB family BED32_15710 ENOG4105E2Z phosphate ABC transporter (Permease BED32_15715 ENOG4105C8U phosphate abc transporter BED32_15720 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BED32_15725 ENOG4105C9X ppx gppa phosphatase BED32_15740 ENOG4105BZU Histidine kinase BED32_15745 ENOG4105R8A Heat shock protein BED32_15750 ENOG4105ENT Efflux transporter rnd family, mfp subunit BED32_15760 ENOG4105BZS acriflavin resistance protein BED32_15765 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED32_15770 ENOG4105EB3 Histidine kinase BED32_15775 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED32_15780 ENOG4105KWI UPF0339 protein BED32_15785 ENOG4105CFP Peptidase U32 BED32_15795 ENOG410787A Pts system, glucitol sorbitol-specific BED32_15800 ENOG4105DZY Pts system, glucitol sorbitol-specific BED32_15805 ENOG4105VI0 Pts system, glucitol sorbitol-specific BED32_15810 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase BED32_15815 ENOG4105J92 DNA-binding transcriptional activator GutM BED32_15820 ENOG410804X Transcriptional regulator BED32_15825 ENOG4105C2X Arabinose 5-phosphate isomerase BED32_15830 ENOG4108ZGU inhibitor of vertebrate lysozyme BED32_15840 ENOG4105DWF phosphomethylpyrimidine kinase BED32_15865 ENOG4105D5G Transposase BED32_15905 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_15930 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BED32_15935 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BED32_15940 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BED32_15945 ENOG4105VPD cellular component movement BED32_15955 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_15960 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BED32_15970 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BED32_15980 ENOG4105CUT histidyl-tRNA synthetase BED32_15985 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BED32_15990 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BED32_16000 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BED32_16015 ENOG4108JQB penicillin-binding protein 1C BED32_16020 ENOG4105DN3 alpha-2-macroglobulin domain protein BED32_16025 ENOG4108MGN ATP-binding component of a transport system BED32_16030 ENOG4105YYA enhanced serine sensitivity protein SseB BED32_16040 ENOG4105WVQ Fe-S assembly protein IscX BED32_16045 ENOG4108ZIT Ferredoxin, 2FE-2S BED32_16050 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BED32_16055 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BED32_16060 ENOG4108Z4V iron-sulfur cluster assembly BED32_16065 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BED32_16070 ENOG4105C3J Cysteine desulfurase BED32_16075 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BED32_16080 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BED32_16090 ENOG4105D7X high-affinity nickel-transporter BED32_16095 ENOG41065CD Exported protein BED32_16105 ENOG4105D8G Major Facilitator superfamily BED32_16110 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BED32_16115 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BED32_16120 ENOG4108M21 BED32_16125 ENOG4105RMW regulation of transcription, DNA-dependent BED32_16130 ENOG4108626 Racemase BED32_16135 ENOG41080QX K07048 phosphotriesterase-related protein BED32_16140 ENOG4105MUZ Protein of unknown function DUF2620 BED32_16145 ENOG4106M0N transport system permease protein BED32_16150 ENOG4108YZA Nitrogen regulatory protein pii BED32_16155 ENOG4105C4K Nad synthetase BED32_16160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BED32_16165 ENOG4108SKK alpha helix protein BED32_16170 ENOG4107WP9 Histidine kinase BED32_16185 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BED32_16190 ENOG4108Z6B deaminase BED32_16200 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB BED32_16210 ENOG4106G6Q Transcriptional regulator BED32_16215 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BED32_16225 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BED32_16230 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BED32_16235 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BED32_16240 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BED32_16245 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BED32_16250 ENOG4105C3F Signal peptidase i BED32_16255 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BED32_16265 ENOG4105WMJ Positive regulator of sigma E, RseC MucC BED32_16270 ENOG4105VQK sigma E regulatory protein, MucB RseB BED32_16275 ENOG41069PW sigma-e factor negative regulatory protein BED32_16285 ENOG4108IYU L-aspartate oxidase BED32_16290 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BED32_16295 ENOG4105C1J atp-dependent rna helicase BED32_16300 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_16305 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_16325 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) BED32_16330 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BED32_16335 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BED32_16340 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BED32_16345 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BED32_16350 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BED32_16360 ENOG4108Z1B Cyclase dehydrase BED32_16365 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BED32_16380 ENOG4105CHH sulfate transporter BED32_16385 ENOG410901P UPF0249 protein BED32_16390 ENOG4105EZV Transcriptional regulator BED32_16395 ENOG4105VCP PTS System BED32_16400 ENOG4105CS2 ec 3.2.1.21 BED32_16405 ENOG4105CK1 PTS System BED32_16410 ENOG4105VZJ PTS System BED32_16420 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_16425 ENOG4105CPC Aldo Keto reductase BED32_16435 ENOG41086WQ Protein CrcB homolog BED32_16440 ENOG4107SVH Potassium channel protein BED32_16445 ENOG4105XXV Acid-resistance protein BED32_16460 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BED32_16465 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BED32_16470 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BED32_16480 ENOG4105CQM Urea amidohydrolase subunit alpha BED32_16485 ENOG4105KI2 Urea amidohydrolase subunit beta BED32_16495 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) BED32_16505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED32_16545 ENOG4105VEQ Cold shock protein BED32_16560 ENOG4108WMJ Protein of unknown function (DUF2002) BED32_16565 ENOG4105F9N Major Facilitator Superfamily BED32_16570 ENOG41075H3 AraC family transcriptional regulator BED32_16585 ENOG4105TNS Conserved Protein BED32_16595 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BED32_16605 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BED32_16615 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BED32_16620 ENOG4108IJ7 Glycine betaine BED32_16625 ENOG4108HQS Glycine betaine BED32_16630 ENOG4105GIJ Glycine betaine BED32_16640 ENOG4108JDX DNA polymerase iii, epsilon subunit BED32_16645 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BED32_16650 ENOG4105D1A Methyltransferase BED32_16655 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BED32_16660 ENOG4105E9H Lytic Murein transglycosylase BED32_16665 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_16670 ENOG4107NA1 Endonuclease Exonuclease phosphatase BED32_16675 ENOG4105F27 Major Facilitator BED32_16680 ENOG4105HEI LysR family (Transcriptional regulator BED32_16685 ENOG4105CV8 reductase BED32_16695 ENOG4105D5G Transposase BED32_16740 ENOG4108UMI ABC transporter, permease BED32_16745 ENOG4105D01 (LipO)protein BED32_16750 ENOG4108R8X outer membrane lipoprotein BED32_16755 ENOG4108R96 Methyltransferase, YaeB family BED32_16760 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BED32_16765 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion BED32_16770 ENOG4108YZN class I peptide chain release factor BED32_16775 ENOG4108VWS Yaeq family BED32_16785 ENOG4105M1T rho-binding antiterminator BED32_16790 ENOG4105N7H Cytochrome BED32_16795 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BED32_16800 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BED32_16805 ENOG4105CXN decarboxylase BED32_16810 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BED32_16815 ENOG4105C0B DNA polymerase III (alpha subunit) BED32_16820 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BED32_16825 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BED32_16835 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BED32_16840 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BED32_16845 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) BED32_16855 ENOG4105DZP Membrane-associated zinc metalloprotease BED32_16860 ENOG4105KNE Phosphatidate cytidylyltransferase BED32_16865 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BED32_16870 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BED32_16875 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BED32_16880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BED32_16885 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BED32_16890 ENOG4105CE9 30S ribosomal protein S2 BED32_16900 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BED32_16905 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BED32_16910 ENOG4108T8E UPF0325 protein BED32_16915 ENOG4105QDK Flavodoxin BED32_16920 ENOG4105DR9 pseudouridine synthase BED32_16925 ENOG4105WP7 tRNA pseudouridine synthase C BED32_16930 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BED32_16935 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BED32_16940 ENOG4105EWT decarboxylase family BED32_16945 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease BED32_16950 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_16955 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) BED32_16960 ENOG4105M08 Membrane BED32_16965 ENOG4105ETT transcriptional Regulator, LysR family BED32_16970 ENOG4105M5B (LipO)protein BED32_16975 ENOG4105C9B Cysteine desulfurase BED32_16980 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BED32_16985 ENOG4105CUZ uba thif-type nad fad binding protein BED32_16990 ENOG4105CA3 membrane-bound lytic murein transglycosylase BED32_17010 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BED32_17015 ENOG4107QZM n-acetylglutamate synthase BED32_17020 ENOG4107QYX exodeoxyribonuclease v alpha BED32_17025 ENOG4107QKA exodeoxyribonuclease V beta BED32_17030 ENOG4107QXK peptidase BED32_17035 ENOG4105DSY exodeoxyribonuclease V, gamma BED32_17040 ENOG4105RVB Prepilin peptidase dependent protein c BED32_17060 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BED32_17065 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BED32_17070 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BED32_17085 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) BED32_17090 ENOG4105EE5 Membrane protein terC BED32_17095 ENOG4105CPC Aldo Keto reductase BED32_17105 ENOG4105CEY Amp-dependent synthetase and ligase BED32_17115 ENOG41060NJ transcriptional regulator BED32_17120 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BED32_17125 ENOG4105RQF LysR family Transcriptional regulator BED32_17130 ENOG4105F27 Major Facilitator BED32_17200 ENOG4108VAU general secretion pathway protein G BED32_17210 ENOG4107QHF type ii secretion system protein e BED32_17230 ENOG4107B2H carbonic anhydrase BED32_17235 ENOG4105KVH Transcriptional regulator BED32_17240 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BED32_17250 ENOG4105DVC DnaJ domain protein BED32_17255 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_17260 ENOG4105BZU Histidine kinase BED32_17265 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein BED32_17280 ENOG4105D5G Transposase BED32_17285 ENOG4105WJ3 XRE family Transcriptional regulator BED32_17290 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation BED32_17310 ENOG4108KU9 integrase family BED32_17395 ENOG4105CRK lysyL-tRNA synthetase BED32_17400 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BED32_17405 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BED32_17410 ENOG4105T95 Thiol disulfide interChange protein BED32_17415 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED32_17420 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) BED32_17425 ENOG4105CT7 inner membrane cred family protein BED32_17430 ENOG4105EB3 Histidine kinase BED32_17435 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED32_17445 ENOG4105Y75 tpr repeat protein BED32_17450 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BED32_17455 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_17460 ENOG4108UT2 hemolysin iii BED32_17470 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BED32_17480 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BED32_17485 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BED32_17490 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BED32_17495 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BED32_17500 ENOG4105D0A hydroxylase BED32_17505 ENOG4107RAQ aminopeptidase BED32_17510 ENOG4105E07 UPF0149 protein BED32_17515 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BED32_17525 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BED32_17530 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BED32_17535 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BED32_17540 ENOG4105DXN mazG family BED32_17545 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BED32_17550 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BED32_17555 ENOG4105BZU Histidine kinase BED32_17560 ENOG4105C0H protease BED32_17565 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BED32_17570 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BED32_17580 ENOG4105EN6 Membrane BED32_17585 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BED32_17595 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BED32_17600 ENOG4105DQQ Major facilitator superfamily MFS_1 BED32_17605 ENOG4105S6R Iron-hydroxamate transporter permease subunit BED32_17610 ENOG4105J76 Periplasmic binding protein BED32_17615 ENOG4105E0A ABC, transporter BED32_17620 ENOG4105BZ4 penicillin-binding protein BED32_17625 ENOG4105CQ7 ATP-dependent helicase BED32_17630 ENOG4107XID 2'-5' rna ligase BED32_17635 ENOG4105PW4 Sugar fermentation stimulation protein homolog BED32_17640 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BED32_17650 ENOG4105DJ0 Poly(A) Polymerase BED32_17655 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BED32_17660 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BED32_17665 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BED32_17670 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BED32_17675 ENOG4107BJW polysaccharide deacetylase BED32_17680 ENOG4105E3A (ABC) transporter BED32_17685 ENOG4105DA5 (ABC) transporter BED32_17690 ENOG41077A9 carbonic anhydrase BED32_17695 ENOG4108UGV hypoxanthine phosphoribosyltransferase BED32_17700 ENOG4105E3B Multicopper oxidase BED32_17705 ENOG4108ZRK uncharacterized protein yacC BED32_17710 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BED32_17715 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BED32_17725 ENOG4105RPH Inner membrane protein YddG BED32_17730 ENOG4108ZIG UPF0231 protein BED32_17740 ENOG4107RNH Outer membrane receptor FepA BED32_17745 ENOG4105ECQ AraC Family Transcriptional Regulator BED32_17755 ENOG4107QN2 dihydrolipoyl dehydrogenase BED32_17760 ENOG4107QSN dihydrolipoamide acetyltransferase BED32_17765 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BED32_17770 ENOG41073TP transcriptional regulator BED32_17775 ENOG4105C85 amino acid BED32_17780 ENOG4106A72 regulatory protein AmpE BED32_17790 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BED32_17795 ENOG4108ZUW Major pilin subunit BED32_17800 ENOG4107QHF type ii secretion system protein e BED32_17805 ENOG4105D7Q type ii secretion system BED32_17810 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BED32_17815 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BED32_17825 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BED32_17830 ENOG4105M6F mutator MutT protein BED32_17835 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BED32_17840 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) BED32_17855 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BED32_17860 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BED32_17865 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BED32_17875 ENOG4105DFU Cell wall formation (By similarity) BED32_17880 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BED32_17885 ENOG4105CNI cell division protein FtsW BED32_17895 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BED32_17900 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BED32_17905 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BED32_17910 ENOG4105CJN penicillin-binding protein BED32_17920 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BED32_17925 ENOG4108V6E Cell division protein mraZ BED32_17935 ENOG4107B7Y DNA-binding transcriptional regulator FruR BED32_17940 ENOG4108ZP8 Acetolactate synthase small subunit BED32_17945 ENOG4105C7K acetolactate synthase BED32_17950 ENOG4108IQE Amp-dependent synthetase and ligase BED32_17955 ENOG41064T2 transcriptional regulator, lysR family BED32_17960 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BED32_17965 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BED32_17970 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BED32_17990 ENOG4105S8Q sugar efflux transporter BED32_17995 ENOG4105C6N Formate acetyltransferase BED32_18005 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BED32_18020 ENOG4105DP9 ABC transporter BED32_18025 ENOG4106SMU thiamine transporter membrane protein BED32_18035 ENOG4108KF1 Membrane BED32_18040 ENOG4105CQ2 DNA polymerase BED32_18045 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BED32_18055 ENOG4105D3G Pseudouridine synthase BED32_18060 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BED32_18065 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BED32_18070 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BED32_18080 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BED32_18085 ENOG4105NWN ApaG protein BED32_18090 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BED32_18095 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BED32_18100 ENOG4107XM3 UPF0442 protein BED32_18105 ENOG4105DWK Membrane BED32_18110 ENOG4105N14 lysine exporter protein LysE YggA BED32_18115 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BED32_18120 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BED32_18125 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BED32_18130 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BED32_18135 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BED32_18140 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BED32_18145 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BED32_18150 ENOG4105DTN riboflavin biosynthesis protein ribF BED32_18160 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BED32_18165 ENOG41063Z6 transcriptional regulator, lysR family BED32_18170 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BED32_18175 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BED32_18180 ENOG4105CFG Acts as a chaperone (By similarity) BED32_18185 ENOG4106HK8 GPR1 FUN34 yaaH family protein BED32_18200 ENOG4108RIR Molybdenum cofactor biosynthesis protein BED32_18205 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BED32_18210 ENOG4105D1Q UPF0246 protein BED32_18215 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_18225 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BED32_18235 ENOG410759A BED32_18240 ENOG41065U4 response regulator BED32_18245 ENOG4108RH0 Crea protein BED32_18250 ENOG4105UEI Transcriptional Regulator AraC Family BED32_18255 ENOG4105CVJ phosphoglycerate mutase BED32_18265 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) BED32_18270 ENOG4107SC1 transglycosylase BED32_18285 ENOG4108KHX Diguanylate cyclase BED32_18290 ENOG41090EK ompa motb domain protein BED32_18295 ENOG4105C5H ABC transporter BED32_18310 ENOG4105CIS alcohol dehydrogenase BED32_18325 ENOG4105EAC phosphoserine phosphatase BED32_18330 ENOG41062Z9 Membrane BED32_18335 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BED32_18340 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BED32_18345 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BED32_18350 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BED32_18355 ENOG4105D9N nucleoside BED32_18360 ENOG4105EYA deoxyribonuclease BED32_18365 ENOG4108NRW Phospholipase, patatin family BED32_18375 ENOG4105K3G Periplasmic Protein BED32_18380 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BED32_18385 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BED32_18390 ENOG4108WPU DNA polymerase III subunit psi BED32_18395 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BED32_18400 ENOG4105CPC Aldo Keto reductase BED32_18415 ENOG4105YBH Protein of unknown function (DUF1435) BED32_18420 ENOG4105BZU Histidine kinase BED32_18425 ENOG4105GAV receptor BED32_18435 ENOG4105D7K pfkb domain protein BED32_18450 ENOG4108HKT sucrose-6-phosphate hydrolase BED32_18455 ENOG4105WBN Transcriptional regulator (LacI family BED32_18460 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BED32_18510 ENOG4108UTZ Dihydroxyacetone kinase BED32_18515 ENOG4105CMT Dihydroxyacetone kinase BED32_18525 ENOG4105BZS acriflavin resistance protein BED32_18530 ENOG410624X efflux transporter, rnd family, mfp subunit BED32_18535 ENOG4105CEU Arginine dihydrolase BED32_18550 ENOG4105DKP glycosyl transferase, family 9 BED32_18555 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BED32_18560 ENOG4105DKT Transcriptional regulator BED32_18565 ENOG4105C2J ABC transporter BED32_18570 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BED32_18575 ENOG4105F5R ABC transporter BED32_18580 ENOG4105D4B ABC, transporter BED32_18585 ENOG41061GT Aldolase BED32_18590 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound BED32_18600 ENOG4105RI1 glycoprotein receptor BED32_18605 ENOG4105D5G Transposase BED32_18635 ENOG4108K5H permease YjgP YjgQ family protein BED32_18640 ENOG4108M8S permease YjgP YjgQ family protein BED32_18645 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BED32_18650 ENOG4105MYG DNA polymerase iii, chi subunit BED32_18660 ENOG4108MJ3 acetyltransferase BED32_18665 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) BED32_18675 ENOG4105XEP YhcH YjgK YiaL family protein BED32_18685 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BED32_18690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BED32_18695 ENOG4105C3U ABC transporter BED32_18700 ENOG4108JQ7 (ABC) transporter BED32_18715 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BED32_18730 ENOG4107RJJ Transcriptional regulator BED32_18735 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG BED32_18740 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH BED32_18745 ENOG4105EKV Phosphonate metabolism protein BED32_18750 ENOG4105FT8 Phosphonate metabolism BED32_18755 ENOG4105ENV phosphonate C-P lyase system protein PhnK BED32_18760 ENOG4105HRV phosphonate c-p lyase system protein phnl BED32_18765 ENOG4105FD8 phosphonate metabolism protein PhnM BED32_18775 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein BED32_18780 ENOG4105K4T epimerase BED32_18795 ENOG4108ZPB UPF0306 protein BED32_18810 ENOG4105DRS transport system, permease BED32_18815 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BED32_18830 ENOG4105EY3 heparinase II III family protein BED32_18835 ENOG4105CXN decarboxylase BED32_18840 ENOG4105D5Q Arginine ornithine antiporter BED32_18850 ENOG4108YYD acetyltransferase BED32_18855 ENOG4105XPQ lipid carrier protein BED32_18860 ENOG4105CFP Peptidase U32 BED32_18865 ENOG4106RZ4 Peptidase U32 BED32_18870 ENOG4105CEM UPF0597 protein BED32_18875 ENOG4105C44 Serine transporter BED32_18880 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BED32_18885 ENOG4105DEN Luciferase family BED32_18895 ENOG4105C1J atp-dependent rna helicase BED32_18905 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BED32_18910 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BED32_18915 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BED32_18920 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BED32_18925 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BED32_18930 ENOG4105CHV Transcription elongation factor NusA BED32_18935 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BED32_18955 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BED32_18960 ENOG4105EEI dihydropteroate synthase BED32_18965 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BED32_18970 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BED32_18975 ENOG4105HBR Rna-binding protein BED32_18980 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BED32_18985 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BED32_19000 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BED32_19005 ENOG4105QYV Membrane BED32_19010 ENOG4105K46 50S ribosomal protein l27 BED32_19015 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BED32_19020 ENOG4105EAH synthase BED32_19030 ENOG4105HVQ Regulatory factor of maltose metabolism BED32_19035 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BED32_19040 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) BED32_19050 ENOG4105DFU Cell wall formation (By similarity) BED32_19055 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BED32_19060 ENOG4105C8Q Methyl-accepting chemotaxis BED32_19065 ENOG4105F0N pyrophosphate phospho-hydrolase BED32_19070 ENOG4108ZHD aig2 family BED32_19085 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BED32_19090 ENOG4105C37 (CBS) domain BED32_19095 ENOG41061GZ Protein of unknown function (DUF1107) BED32_19100 ENOG4108UUE Transcriptional regulator BED32_19105 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BED32_19110 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BED32_19120 ENOG4108V1T peptidylprolyl cis-trans isomerase BED32_19125 ENOG4105FHY Opacity-associated protein A BED32_19135 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BED32_19140 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BED32_19145 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) BED32_19150 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BED32_19160 ENOG4108MXZ Esterase BED32_19165 ENOG4105WSB biofilm stress and motility protein A BED32_19170 ENOG4105CSU acyl-Coa dehydrogenase BED32_19175 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_19180 ENOG4105C2N RNA methyltransferase TrmH family group 3 BED32_19185 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BED32_19190 ENOG4105KPV Transcriptional regulator BED32_19195 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BED32_19205 ENOG4105EPW hflc protein BED32_19210 ENOG4107QJR hflk protein BED32_19215 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BED32_19220 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BED32_19225 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BED32_19230 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BED32_19235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BED32_19240 ENOG4105K8N protein family UPF0079, ATPase BED32_19245 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BED32_19250 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BED32_19265 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BED32_19270 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BED32_19275 ENOG4105DJ4 phosphatidylserine decarboxylase BED32_19280 ENOG4105EGS Mechanosensitive ion channel BED32_19285 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BED32_19300 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BED32_19305 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BED32_19315 ENOG4105KPY Small multidrug resistance protein BED32_19325 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BED32_19330 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BED32_19335 ENOG4108ZVF (LipO)protein BED32_19345 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BED32_19350 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BED32_19365 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BED32_19375 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BED32_19380 ENOG4105BZW Glycerate kinase BED32_19385 ENOG4108SIC Transcriptional regulator BED32_19395 ENOG4105C6N Formate acetyltransferase BED32_19400 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BED32_19405 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) BED32_19410 ENOG4105C7B Threonine dehydratase BED32_19415 ENOG4105D4P Coproporphyrinogen iii oxidase BED32_19420 ENOG41090JE Utilization Protein BED32_19430 ENOG4107F3C Hemin uptake protein BED32_19435 ENOG4107ENK receptor BED32_19440 ENOG4106QJH hemin transport protein BED32_19445 ENOG4107R4I Periplasmic binding protein BED32_19450 ENOG4105EHG Permease protein BED32_19455 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BED32_19470 ENOG4105E0K tonB-dependent siderophore receptor BED32_19485 ENOG4105VTW prevent-host-death family BED32_19495 ENOG4105CQ0 ABC transporter BED32_19500 ENOG4105PE1 Receptor BED32_19505 ENOG4108S3W Anti-feci sigma factor, fecr BED32_19520 ENOG4105KSU Redox protein BED32_19525 ENOG41066VF YeeE YedE family protein BED32_19530 ENOG4108IUF type iii secretion BED32_19535 ENOG4108TN6 type iii secretion BED32_19540 ENOG41083GP type iii secretion BED32_19545 ENOG4108HHI Type III secretion system protein BED32_19550 ENOG41063Q7 Type III secretion system protein BED32_19565 ENOG4108JIR Flagellum-specific ATP synthase BED32_19575 ENOG4106H1D secretion system apparatus protein BED32_19580 ENOG4105UQF type iii secretion BED32_19640 ENOG4108SZ7 secretion system effector BED32_19685 ENOG4105WH1 Two component transcriptional regulator luxr family BED32_19690 ENOG4105CK2 sodium dicarboxylate symporter BED32_19695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BED32_19700 ENOG41062QD Membrane BED32_19705 ENOG4107QN1 sodium solute BED32_19750 ENOG4105DC1 bifunctional purine biosynthesis protein purh BED32_19755 ENOG4105C12 Phosphoribosylglycinamide synthetase BED32_19760 ENOG4108T8B Protein of unknown function (DUF1481) BED32_19770 ENOG4105R2J Conserved Protein BED32_19775 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BED32_19780 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BED32_19785 ENOG4105E09 nadh pyrophosphatase BED32_19790 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor BED32_19795 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BED32_19805 ENOG4105D06 uba thif-type nad fad binding protein BED32_19810 ENOG4105WHD thiamine biosynthesis protein ThiS BED32_19815 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BED32_19820 ENOG4105D41 biosynthesis protein thiH BED32_19825 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_19830 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BED32_19835 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BED32_19845 ENOG4108VZM 50s ribosomal protein L10 BED32_19850 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BED32_19855 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BED32_19860 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BED32_19865 ENOG4105PM1 preprotein translocase subunit SecE BED32_19870 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BED32_19905 ENOG4105CS9 pantothenic acid kinase BED32_19910 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BED32_19920 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_19950 ENOG4108RR8 protoporphyrinogen oxidase BED32_19955 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BED32_19960 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BED32_19965 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) BED32_19970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BED32_19975 ENOG4105CHU acetyl-coa acetyltransferase BED32_19980 ENOG4107QK7 reductase BED32_19985 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BED32_19990 ENOG4105MDZ Transcriptional activator rfaH BED32_19995 ENOG4105D52 delta-aminolevulinic acid dehydratase BED32_20005 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BED32_20010 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BED32_20015 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BED32_20020 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BED32_20025 ENOG4105JC1 sterol-binding domain protein BED32_20030 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BED32_20055 ENOG4108I5U Uridine phosphorylase BED32_20060 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) BED32_20065 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BED32_20070 ENOG4105DZ2 Transcriptional regulator BED32_20075 ENOG4105EMK carboxylate amino acid amine transporter BED32_20080 ENOG4105RK9 auxin efflux carrier BED32_20085 ENOG4107T6V glycerophosphoryl diester phosphodiesterase BED32_20090 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BED32_20095 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BED32_20100 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BED32_20105 ENOG4105BZ7 extracellular solute-binding protein family 1 BED32_20140 ENOG4108IV0 ABC, transporter BED32_20145 ENOG4105C0Z ABC transporter BED32_20150 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BED32_20155 ENOG4105C32 Amino acid ABC transporter (Permease) BED32_20160 ENOG4105CP9 extracellular ligand-binding receptor BED32_20165 ENOG4105U59 -acetyltransferase BED32_20185 ENOG4105CRP Part of the ABC transporter FtsEX involved in BED32_20190 ENOG4105CAK Cell division ATP-binding protein ftsE BED32_20195 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BED32_20200 ENOG4106H78 methyltransferase BED32_20205 ENOG4105MG3 Membrane BED32_20220 ENOG4107FS9 Membrane BED32_20225 ENOG4105C59 p-type ATPase BED32_20230 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BED32_20235 ENOG4105EX9 Membrane BED32_20240 ENOG4108W1V Lipoprotein BED32_20245 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BED32_20250 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B BED32_20255 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A BED32_20260 ENOG4105CXY transporter BED32_20265 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BED32_20270 ENOG4105DQF Hydrolase BED32_20275 ENOG4108EUD Lysophospholipase BED32_20285 ENOG4105CCF Lysine exporter protein (Lyse ygga) BED32_20290 ENOG4105C9U ATP-dependent DNA helicase RecQ BED32_20295 ENOG4105HDD phospholipase BED32_20300 ENOG4108VUY thioesterase Superfamily protein BED32_20305 ENOG4105FR1 rard protein BED32_20310 ENOG4107QUT magnesium and cobalt transport protein CorA BED32_20320 ENOG4105EQN UPF0261 protein BED32_20330 ENOG4105C4R Atp-dependent dna helicase BED32_20335 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant BED32_20340 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BED32_20345 ENOG4105CT0 Protein of unknown function, DUF484 BED32_20350 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BED32_20355 ENOG4105S7Z (LipO)protein BED32_20360 ENOG4105XQ6 frataxin-like protein BED32_20375 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BED32_20380 ENOG41076E6 Uroporphyrinogen-III Synthase BED32_20385 ENOG4105ECF c-methyltransferase BED32_20390 ENOG410601J HemY protein BED32_20395 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_20435 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) BED32_20440 ENOG4105EGZ biosynthesis protein BED32_20445 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BED32_20450 ENOG4108WJ1 acetyltransferase BED32_20455 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BED32_20460 ENOG4105C1B dTDP-glucose 4-6-dehydratase BED32_20465 ENOG4108IJ1 Dehydrogenase BED32_20470 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BED32_20475 ENOG4105SFE lipopolysaccharide biosynthesis protein BED32_20480 ENOG4105ESV Glycosyl transferase, family 4 BED32_20485 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_20495 ENOG4105K63 Thioredoxin BED32_20505 ENOG4105C9X ppx gppa phosphatase BED32_20515 ENOG4105C4R Atp-dependent dna helicase BED32_20520 ENOG4105KQ5 peptidylprolyl cis-trans isomerase BED32_20550 ENOG4107R3N Filamentation induced by cAMP protein fic BED32_20585 ENOG4105DFP Integrase BED32_20590 ENOG4105T16 Transcriptional regulator (AraC family) BED32_20595 ENOG4107RNG ABC transporter BED32_20605 ENOG4105DFW ABC transporter BED32_20610 ENOG4105C93 Xylose Isomerase BED32_20615 ENOG4105CMG Carbohydrate kinase BED32_20620 ENOG4108TTM chaperone BED32_20635 ENOG4105MEV Acyl-transferase BED32_20645 ENOG4105EM7 Selenocysteine-specific translation elongation factor BED32_20650 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) BED32_20655 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) BED32_20660 ENOG4108MG3 formate dehydrogenase BED32_20665 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BED32_20670 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BED32_20675 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BED32_20680 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BED32_20685 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BED32_20690 ENOG4105C8Q Methyl-accepting chemotaxis BED32_20695 ENOG4108RPX mosc domain containing protein BED32_20700 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A BED32_20710 ENOG4108YYI Protein of unknown function (DUF2810) BED32_20715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BED32_20725 ENOG4105E61 Mannitol repressor protein BED32_20730 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BED32_20735 ENOG4105CTS PTS system mannitol-specific BED32_20740 ENOG4106JH6 (LipO)protein BED32_20745 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BED32_20750 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BED32_20755 ENOG4108R3E Dna-3-methyladenine glycosylase i BED32_20760 ENOG4105HNP -acetyltransferase BED32_20790 ENOG4105C5I Dehydrogenase BED32_20795 ENOG4107T9C Alpha amylase catalytic region BED32_20800 ENOG4105JKW Valine--pyruvate aminotransferase BED32_20805 ENOG4105D0C transport protein BED32_20810 ENOG4105EQR Transposase IS116 IS110 IS902 BED32_20815 ENOG4105E5M Multidrug resistance protein D BED32_20830 ENOG4105DP0 ferredoxin-NADP reductase BED32_20835 ENOG4108VTS Membrane BED32_20840 ENOG4105EBK exported protein BED32_20845 ENOG4105CP7 Triose-phosphate isomerase BED32_20855 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BED32_20865 ENOG41076HS cation diffusion facilitator family transporter BED32_20870 ENOG4105FMW periplasmic BED32_20875 ENOG4105E3W Two component transcriptional regulator (Winged helix family BED32_20880 ENOG4105E0F Histidine kinase BED32_20885 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BED32_20890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BED32_20895 ENOG4105D7W serine acetyltransferase BED32_20900 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BED32_20905 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BED32_20910 ENOG4105VW4 glutaredoxin 3 BED32_20915 ENOG4107YZP Rhodanese domain protein BED32_20920 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BED32_20925 ENOG41063SB peptidase BED32_20930 ENOG4105PXI polysaccharide deacetylase BED32_20945 ENOG4105CPQ Dehydrogenase BED32_20950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BED32_20955 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BED32_20960 ENOG4105XA0 heptosyltransferase ii BED32_20965 ENOG4105D16 lipopolysaccharide heptosyltransferase i BED32_20970 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BED32_20980 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BED32_20985 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BED32_20990 ENOG4105W0E 50S ribosomal protein L33 BED32_20995 ENOG4105KDC 50s ribosomal protein l28 BED32_21000 ENOG4105W5Q DNA repair protein (RadC BED32_21005 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BED32_21010 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BED32_21015 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BED32_21020 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BED32_21025 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BED32_21030 ENOG4105DSJ YicC domain protein BED32_21035 ENOG4105DFP Integrase BED32_21055 ENOG4105XB7 anti-repressor protein BED32_21135 ENOG4105BZU Histidine kinase BED32_21140 ENOG4105E39 Enoyl-CoA hydratase BED32_21145 ENOG4105D9N nucleoside BED32_21160 ENOG4105EN6 Membrane BED32_21175 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BED32_21180 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BED32_21185 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase BED32_21190 ENOG4105CB5 ATP-dependent DNA helicase recG BED32_21195 ENOG4105D6U Sodium Glutamate Symporter BED32_21200 ENOG4105C2W permease BED32_21205 ENOG4105JV1 AsmA family BED32_21220 ENOG4105HVQ Regulatory factor of maltose metabolism BED32_21225 ENOG4105SUU thioesterase domain BED32_21230 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BED32_21235 ENOG4107S2Z UPF0761 membrane protein BED32_21240 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 BED32_21250 ENOG4105C5F glutamine synthetase BED32_21260 ENOG4105CUX Signal transduction histidine kinase BED32_21265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BED32_21270 ENOG4105D4P Coproporphyrinogen iii oxidase BED32_21275 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BED32_21280 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BED32_21285 ENOG4105C2M dna polymerase I BED32_21290 ENOG4108Z33 Thiol disulfide Interchange Protein BED32_21295 ENOG4105E27 serine threonine protein kinase BED32_21300 ENOG4105PC1 Conserved Protein BED32_21310 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b BED32_21345 ENOG4107EJG GntR family transcriptional regulator BED32_21350 ENOG4105C0R drug resistance transporter emrb qaca subfamily BED32_21355 ENOG4105ETE Transcriptional regulator (LacI family BED32_21360 ENOG4108RVA ribokinase BED32_21365 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BED32_21370 ENOG4105CNN ABC, transporter BED32_21380 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BED32_21390 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) BED32_21395 ENOG4105EV2 VWA domain protein interacting with AAA ATPase BED32_21405 ENOG4105CU9 asparagine synthetase A BED32_21410 ENOG4108VVK transcriptional Regulator, AsnC BED32_21415 ENOG4105QTB Flavodoxin BED32_21420 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BED32_21425 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BED32_21430 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation BED32_21435 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BED32_21440 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BED32_21445 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BED32_21450 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BED32_21455 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BED32_21460 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BED32_21465 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BED32_21470 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BED32_21475 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BED32_21480 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BED32_21485 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BED32_21490 ENOG4105C8U phosphate abc transporter BED32_21495 ENOG4105E2Z phosphate ABC transporter (Permease BED32_21515 ENOG4106PMH Extracellular solute-binding protein family 3 BED32_21525 ENOG4105DRP amino acid AbC transporter BED32_21530 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 BED32_21535 ENOG4105C7N Xanthine uracil vitamin C permease BED32_21545 ENOG4108ZXC Two component transcriptional regulator, luxr family BED32_21550 ENOG4105BZU Histidine kinase BED32_21555 ENOG4108YYH Nadph-dependent fmn reductase BED32_21560 ENOG4105C8Q Methyl-accepting chemotaxis BED32_21565 ENOG4108UMI ABC transporter, permease BED32_21580 ENOG4105RKW reductase (By BED32_21585 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BED32_21590 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BED32_21600 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BED32_21605 ENOG4105VG0 50S ribosomal protein l34 BED32_21615 ENOG4108BUD transposase BED32_21645 ENOG4105TNG K13735 adhesin invasin BED32_21830 ENOG410607W Transposase BED32_21970 ENOG4105D5K Hemolysin activator protein BED32_21975 ENOG4105CKT filamentous hemagglutinin BED32_22110 ENOG4105TNG K13735 adhesin invasin