locus-tag class description Y11_00001 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) Y11_00011 ENOG4105K89 arsenate reductase Y11_00021 ENOG4105ERG peptidase m48, ste24p Y11_00031 ENOG4105C02 permease Y11_00051 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Y11_00061 ENOG4105RH4 Glycine cleavage system transcriptional repressor Y11_00071 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Y11_00081 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Y11_00091 ENOG4105C8V SAICAR synthetase Y11_00101 ENOG4105CGZ zinc metallopeptidase Y11_00111 ENOG4108VMM UPF0756 membrane protein Y11_00121 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) Y11_00151 ENOG4106KED esterase YpfH Y11_00171 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 Y11_00181 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_00191 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_00221 ENOG4108T1M outer membrane protein x Y11_00251 ENOG4105XYK UPF0370 protein Y11_00271 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Y11_00281 ENOG4105KUZ arsenate reductase Y11_00321 ENOG4105BZS acriflavin resistance protein Y11_00341 ENOG4105WH1 Two component transcriptional regulator luxr family Y11_00361 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase Y11_00371 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Y11_00381 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) Y11_00391 ENOG4105CUW cytochrome C-TYPE protein Y11_00401 ENOG4107VIJ nudix hydrolase Y11_00411 ENOG4105C6K Malic enzyme Y11_00421 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_00451 ENOG4108UPT UPF0178 protein Y11_00461 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Y11_00471 ENOG4108R6G acetyltransferase Y11_00481 ENOG4105H4F exported protein Y11_00491 ENOG4105E7K (LipO)protein Y11_00501 ENOG4105EZR dyp-type peroxidase family protein Y11_00571 ENOG4108R66 Conserved Protein Y11_00581 ENOG4105QEK Transcriptional regulator Y11_00611 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein Y11_00621 ENOG4108I5D sulfate abc transporter Y11_00631 ENOG4105ECW sulfate abc transporter Y11_00651 ENOG4105C6T cysteine synthase Y11_00681 ENOG4105DJY efflux transporter, rnd family, mfp subunit Y11_00691 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Y11_00701 ENOG4105E3W Two component transcriptional regulator (Winged helix family Y11_00711 ENOG4105E0F Histidine kinase Y11_00721 ENOG4105C5Y PTS System Y11_00731 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Y11_00741 ENOG4105KZ7 phosphocarrier protein hpr Y11_00751 ENOG4105C6T cysteine synthase Y11_00781 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Y11_00791 ENOG4105VRT cytoplasmic protein Y11_00831 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Y11_00841 ENOG4105D9N nucleoside Y11_00851 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Y11_00871 ENOG4105CPC Aldo Keto reductase Y11_00891 ENOG4107RA9 decarboxylase Y11_00901 ENOG4105C5Q Transcriptional regulator Y11_00921 ENOG4105CHC glucokinase (EC 2.7.1.2) Y11_00931 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_00941 ENOG4105FCD Major Facilitator Y11_00951 ENOG4105DY9 regulatoR Y11_00961 ENOG4108HRK Histidine kinase Y11_00971 ENOG41072TH Protein of unknown function (DUF1479) Y11_00991 ENOG4105CHM Aminotransferase Y11_01001 ENOG4108VKM cytochrome b561 Y11_01011 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin Y11_01021 ENOG4106B0W Curli production assembly transport component CsgG Y11_01041 ENOG4105E82 cytochrome subunit of dehydrogenase Y11_01051 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y11_01081 ENOG4105CVE Lytic murein transglycosylase Y11_01091 ENOG4105CUB amino acid Y11_01141 ENOG4105DHJ ABC, transporter Y11_01191 ENOG4105DS1 cytochrome b561 Y11_01201 ENOG4108YYC ycei family Y11_01211 ENOG4108YYC ycei family Y11_01221 ENOG4105DDV Transcriptional regulator (LacI family Y11_01231 ENOG4105C5Y PTS System Y11_01241 ENOG4105CS2 ec 3.2.1.21 Y11_01261 ENOG4105NTW Transcriptional regulator Y11_01271 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Y11_01291 ENOG4105S64 Formate nitrite transporter Y11_01311 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) Y11_01331 ENOG41060IM Heme exporter protein Y11_01341 ENOG4105X3C heme exporter protein Y11_01351 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) Y11_01361 ENOG4105DA4 cytochrome c-type biogenesis protein Y11_01371 ENOG4107QX9 Thiol disulfide interChange protein Y11_01381 ENOG4108M1T Cytochrome c-type biogenesis protein Y11_01391 ENOG4105KWW Biogenesis protein Y11_01401 ENOG410903C (LipO)protein Y11_01411 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation Y11_01421 ENOG4105KZW UPF0381 protein Y11_01431 ENOG4105CHU acetyl-coa acetyltransferase Y11_01441 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y11_01451 ENOG4108BY2 phosphohistidine phosphatase Y11_01461 ENOG4108DG9 Smr protein MutS2 Y11_01471 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) Y11_01481 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Y11_01491 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) Y11_01501 ENOG4105EJ9 Membrane Y11_01511 ENOG4108BPE -transporting atpase Y11_01521 ENOG4105MH2 YfcL protein Y11_01531 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Y11_01541 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y11_01551 ENOG4105BZU Histidine kinase Y11_01591 ENOG4105VCP PTS System Y11_01601 ENOG4105CS2 ec 3.2.1.21 Y11_01611 ENOG4105CK1 PTS System Y11_01631 ENOG4105ETE Transcriptional regulator (LacI family Y11_01641 ENOG4105D6F Phosphatase Y11_01651 ENOG4105F4P )-transporter Y11_01661 ENOG4106WZ1 flagella biosynthesis regulator Y11_01691 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Y11_01711 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Y11_01721 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y11_01741 ENOG410631K Membrane Y11_01761 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) Y11_01771 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Y11_01791 ENOG4105DQR SNARE associated Golgi Y11_01801 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Y11_01821 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Y11_01831 ENOG4108S3P Sporulation domain protein Y11_01841 ENOG4105E96 Colicin v production protein Y11_01851 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Y11_01861 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Y11_01871 ENOG4105E89 ABC transporter Y11_01881 ENOG4105DSP amino acid AbC transporter Y11_01891 ENOG4106YG3 ABC transporter Y11_01901 ENOG4108JEH abc transporter atp-binding protein Y11_01931 ENOG4105ECP epimerase Y11_01951 ENOG4108RE9 Phosphodiesterase Y11_01961 ENOG4105PTV Nudix Hydrolase Y11_01991 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC Y11_02011 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia Y11_02021 ENOG4107P2S Transcriptional regulator Y11_02031 ENOG4105C6K Malic enzyme Y11_02061 ENOG4105PQ6 UPF0208 membrane protein Y11_02071 ENOG4105XWI UPF0304 protein Y11_02081 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 Y11_02111 ENOG4107QWE )-transporter Y11_02121 ENOG4105DK2 UPF0207 protein Y11_02131 ENOG4105CHM Aminotransferase Y11_02141 ENOG4107NQ8 LysR family Transcriptional regulator Y11_02151 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Y11_02161 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y11_02171 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y11_02181 ENOG4105GKE subunit e Y11_02191 ENOG4107QIZ NADH dehydrogenase Y11_02201 ENOG4108IEH NADH dehydrogenase subunit g Y11_02211 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Y11_02221 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y11_02231 ENOG4107UFS subunit j Y11_02241 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y11_02251 ENOG4105D65 subunit l Y11_02261 ENOG4105C8S subunit m Y11_02271 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y11_02291 ENOG4108UQ5 membrane protein YcdZ Y11_02321 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Y11_02331 ENOG4105CHR reductase Y11_02351 ENOG4105K2J Transcriptional regulator Y11_02361 ENOG4105C5I Dehydrogenase Y11_02371 ENOG4105C5I Dehydrogenase Y11_02391 ENOG41090KN UPF0303 protein Y11_02401 ENOG4105C01 Dihydroxy-acid dehydratase Y11_02411 ENOG4105TNS Conserved Protein Y11_02421 ENOG4105E4F Isochorismate synthase Y11_02441 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Y11_02451 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Y11_02461 ENOG4108IPT Naphthoate synthase Y11_02471 ENOG4105DNI Converts SHCHC to OSB (By similarity) Y11_02481 ENOG4105CEY Amp-dependent synthetase and ligase Y11_02501 ENOG4105CH6 catalase Y11_02511 ENOG4108UII YfaZ family Y11_02521 ENOG4105E0U tyrosine-specific transport protein Y11_02591 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) Y11_02601 ENOG4105XPH Ferredoxin Y11_02611 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Y11_02621 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Y11_02631 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Y11_02641 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y11_02651 ENOG4105BZU Histidine kinase Y11_02661 ENOG41068CG regulatoR Y11_02671 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC Y11_02681 ENOG4106UW1 Major Facilitator superfamily Y11_02721 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Y11_02761 ENOG4107R6D beta-lactam binding protein AmpH Y11_02771 ENOG4105CT4 transporter Y11_02801 ENOG4105C8Q Methyl-accepting chemotaxis Y11_02821 ENOG4105Y50 Virulence Protein Y11_02841 ENOG4105HRS Antitermination protein Y11_02871 ENOG4108Q3X Transcriptional regulator Y11_02891 ENOG4105C5Y PTS System Y11_02901 ENOG4105CS2 ec 3.2.1.21 Y11_02921 ENOG4105D5G Transposase Y11_02951 ENOG4105E68 Sulfatase Y11_02961 ENOG4105PAN UPF0352 protein Y11_02971 ENOG4106V8H Nucleoid-associated protein Y11_02981 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Y11_02991 ENOG4105CFI type iii restriction protein res subunit Y11_03001 ENOG4105I08 Pseudouridine synthase Y11_03011 ENOG4105C2C drug resistance transporter, Bcr CflA Y11_03021 ENOG4105HG6 Y11_03031 ENOG4108JQ5 ABC transporter Y11_03041 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component Y11_03051 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component Y11_03061 ENOG4105E43 Extracellular solute-binding protein, family 5 Y11_03071 ENOG4105CXC rtn protein Y11_03081 ENOG4107TT5 NLP P60 protein Y11_03091 ENOG41076MN Phosphoesterase, PA-phosphatase related Y11_03101 ENOG4105CKI cobalamin synthesis protein Y11_03121 ENOG4107YCY Transcriptional regulator Y11_03131 ENOG4105DEI Mannitol dehydrogenase Y11_03151 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) Y11_03161 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Y11_03201 ENOG4107QY8 reductase Y11_03211 ENOG4105CUW cytochrome C-TYPE protein Y11_03241 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein Y11_03251 ENOG4105DE4 1-phosphofructokinase Y11_03261 ENOG4105DM4 PTS System Y11_03271 ENOG4105DM4 PTS System Y11_03281 ENOG4108SGD regulatory protein Y11_03311 ENOG4108UIF Chaperone Y11_03321 ENOG4108UIF Chaperone Y11_03331 ENOG4108D1K outer membrane usher protein Y11_03341 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Y11_03351 ENOG4105HMI Membrane Y11_03381 ENOG4105DUM transcriptional regulator, lysR family Y11_03391 ENOG4108IQI permease Y11_03401 ENOG4105EHG Permease protein Y11_03421 ENOG4105D05 Receptor Y11_03431 ENOG4108TGY Glutathione S-transferase Y11_03471 ENOG4105D01 (LipO)protein Y11_03491 ENOG4108UMI ABC transporter, permease Y11_03501 ENOG4105C28 cystathionine Y11_03521 ENOG4105DZ1 carboxypeptidase Y11_03531 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_03541 ENOG4105EJQ L-serine dehydratase Y11_03551 ENOG4105C44 Serine transporter Y11_03561 ENOG4107FB0 transcriptional regulator DeoR family Y11_03571 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Y11_03581 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Y11_03601 ENOG4105D0C transport protein Y11_03611 ENOG41090BQ Glutaredoxin Y11_03621 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress Y11_03631 ENOG4108RMJ sensory transduction regulator Y11_03641 ENOG4107RUE extracellular solute-binding protein family 1 Y11_03661 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y11_03671 ENOG4105F38 ABC transporter, permease Y11_03681 ENOG4105D38 putrescine abc transporter Y11_03701 ENOG4105RBQ inner membrane protein ybjO Y11_03711 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) Y11_03721 ENOG4106TNF Periplasmic binding protein Y11_03741 ENOG4105DMR ABC, transporter Y11_03751 ENOG4105GBT ABC transporter Y11_03761 ENOG4106PMH Extracellular solute-binding protein family 3 Y11_03771 ENOG4105E5Z arginine transporter ATP-binding subunit Y11_03781 ENOG41064MM (LipO)protein Y11_03791 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase Y11_03801 ENOG4105CGD Nad-dependent epimerase dehydratase Y11_03811 ENOG4105C5W Aldolase Y11_03831 ENOG4105C7K acetolactate synthase Y11_03841 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Y11_03851 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Y11_03861 ENOG4105DWU Membrane Y11_03871 ENOG4105CPB ATP-dependent endonuclease of the OLD family Y11_03881 ENOG4108MJ5 VirK protein Y11_03891 ENOG4105DJY efflux transporter, rnd family, mfp subunit Y11_03911 ENOG4105VEQ Cold shock protein Y11_03921 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Y11_03931 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y11_03941 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Y11_03951 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Y11_03961 ENOG4108JJ8 (ABC) transporter Y11_03971 ENOG4108JJ9 ABC, transporter Y11_03981 ENOG4105C3M thioredoxin reductase Y11_03991 ENOG4105EW9 transcriptional regulator AsnC family Y11_04001 ENOG4105CNU cell division protein FtsK Y11_04011 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Y11_04021 ENOG4105D1H recombination factor protein RarA Y11_04031 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Y11_04041 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_04051 ENOG4105D5G Transposase Y11_04061 ENOG4108ISG Major Facilitator Y11_04071 ENOG4105F1A Pyruvate formate-lyase Y11_04081 ENOG4105C6N Formate acetyltransferase Y11_04091 ENOG4105TMB Formate nitrite transporter Y11_04121 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_04141 ENOG4105DDY UPF0142 protein ycaO Y11_04151 ENOG4105HDK L-asparaginase Y11_04161 ENOG4105HDK L-asparaginase Y11_04171 ENOG4107VMU Membrane Y11_04181 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Y11_04191 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Y11_04201 ENOG4105CAT Cytidine monophosphate kinase Y11_04211 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Y11_04221 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Y11_04231 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 Y11_04251 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Y11_04261 ENOG4105E32 cytoplasmic protein Y11_04271 ENOG4105VEQ Cold shock protein Y11_04291 ENOG4105VEQ Cold shock protein Y11_04301 ENOG4105W49 UPF0434 protein Y11_04311 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Y11_04321 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups Y11_04331 ENOG4107S90 membrAne Y11_04351 ENOG4106371 Methyltransferase Y11_04361 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) Y11_04371 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) Y11_04381 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) Y11_04391 ENOG4105DIT ErfK YbiS YcfS YnhG family protein Y11_04401 ENOG4105EAQ (twin-arginine translocation) pathway signal Y11_04411 ENOG4105C5X domain protein Y11_04421 ENOG4105BZU Histidine kinase Y11_04431 ENOG4105CGF Aromatic amino acid aminotransferase Y11_04451 ENOG4105C5S asparaginyl-tRNA synthetase Y11_04461 ENOG4107RH7 Nicotinate phosphoribosyltransferase Y11_04471 ENOG4105CD8 aminopeptidase N Y11_04481 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Y11_04501 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) Y11_04511 ENOG4105QVC MOSC domain-containing protein Y11_04521 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Y11_04531 ENOG4105C5H ABC transporter Y11_04541 ENOG4105F1S paraquat-inducible protein a Y11_04551 ENOG4105DY2 Paraquat-inducible protein b Y11_04561 ENOG4108Q2G (LipO)protein Y11_04571 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) Y11_04581 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y11_04601 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) Y11_04611 ENOG4105DAN ATP-dependent protease Y11_04621 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) Y11_04631 ENOG4105UYK outer membrane protein a Y11_04641 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) Y11_04651 ENOG4108RZ1 DNA transformation protein Y11_04671 ENOG4105EM2 membrane Y11_04681 ENOG410901E Membrane Y11_04691 ENOG41088T4 Helicase IV Y11_04701 ENOG4108Z5K methylglyoxal synthase Y11_04711 ENOG4108Q67 UPF0319 protein Y11_04721 ENOG4105K4P CoA-binding domain protein Y11_04731 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) Y11_04741 ENOG4105DR4 Methyltransferase Y11_04771 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 Y11_04781 ENOG4108Z0T Part of a sulfur-relay system (By similarity) Y11_04801 ENOG4105EAU Plays a role in nitrite reduction (By similarity) Y11_04811 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit Y11_04821 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Y11_04831 ENOG4105DVI reductase, NrfD Y11_04841 ENOG4105DA4 cytochrome c-type biogenesis protein Y11_04851 ENOG4107QX9 Thiol disulfide interChange protein Y11_04871 ENOG4108W0S formate-dependent nitrite reductase complex Y11_04881 ENOG4105VJY transcriptional regulator Y11_04891 ENOG4107YC3 synthase Y11_04921 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) Y11_04931 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_04961 ENOG4105DJ9 glucan biosynthesis protein Y11_04971 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) Y11_04981 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_04991 ENOG4105DUX Transporter Y11_05001 ENOG4105C6X Major Facilitator Y11_05011 ENOG4108VGI doxx family Y11_05041 ENOG4105D1S lipid A biosynthesis Y11_05051 ENOG4108ZXC Two component transcriptional regulator, luxr family Y11_05061 ENOG4106AFQ Histidine kinase Y11_05071 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Y11_05081 ENOG4106WHD Tetrathionate reductase Y11_05091 ENOG4105DB1 molybdopterin oxidoreductase Y11_05111 ENOG4105C72 UPF0176 protein Y11_05121 ENOG4105DSF transport protein Y11_05161 ENOG4105PVA Biofilm formation regulatory protein BssS Y11_05181 ENOG4105EKE dihydroorotase Y11_05191 ENOG41067V3 Antibiotic biosynthesis monooxygenase Y11_05201 ENOG4107QQB Ribonuclease E Y11_05201 ENOG4107QQB Ribonuclease E Y11_05211 ENOG4105EI2 Pseudouridine synthase Y11_05231 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein Y11_05241 ENOG4105VGS 50s ribosomal protein l32 Y11_05251 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Y11_05261 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Y11_05271 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Y11_05281 ENOG4105CHR reductase Y11_05301 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y11_05311 ENOG4105YAZ 4-amino-4-deoxychorismate lyase Y11_05321 ENOG4105HHA aminodeoxychorismate lyase Y11_05331 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Y11_05341 ENOG4107QRG dna polymerase iii Y11_05351 ENOG4105F8V Hydrolase, tatD family Y11_05361 ENOG4105CI1 PTS System Y11_05381 ENOG4108JJA ABC, transporter Y11_05401 ENOG4105C4X radical SAM domain protein Y11_05431 ENOG4105F9E Shikimate 5-dehydrogenase Y11_05441 ENOG4105K59 histidine triad (HIT) protein Y11_05451 ENOG41090DQ Lipoprotein Y11_05461 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) Y11_05481 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Y11_05491 ENOG4105D0Y UPF0227 protein Y11_05501 ENOG4105CEP NADH dehydrogenase Y11_05511 ENOG4107MBR 17 kDa surface antigen Y11_05521 ENOG4108JA2 transcriptioN-repair coupling factor Y11_05531 ENOG4105D60 lipoprotein releasing system transmembrane protein Y11_05551 ENOG4105D60 lipoprotein releasing system transmembrane protein Y11_05561 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) Y11_05571 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Y11_05591 ENOG4105EZE Cupin 4 family protein Y11_05611 ENOG4105XJC Two component transcriptional regulator (Winged helix family Y11_05631 ENOG4107QTF adenylosuccinate lyase Y11_05641 ENOG41075W9 High frequency lysogenization protein HflD homolog Y11_05651 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Y11_05671 ENOG4108R99 pseudouridine synthase Y11_05681 ENOG4108HMX isocitrate dehydrogenase (NADP) Y11_05751 ENOG4108HMX isocitrate dehydrogenase (NADP) Y11_05801 ENOG4108HKT sucrose-6-phosphate hydrolase Y11_05811 ENOG4106NDP Transcriptional regulator Y11_05831 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Y11_05841 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Y11_05851 ENOG4105KT5 UmuD protein Y11_05871 ENOG4108IQK o-acetylhomoserine Y11_05881 ENOG4105ECR NmrA family Y11_05891 ENOG4105KVH Transcriptional regulator Y11_05941 ENOG4105DWP Membrane Y11_05971 ENOG4105VTN Protein of unknown function (DUF1311) Y11_05981 ENOG4105XXV Acid-resistance protein Y11_06031 ENOG4105BZ1 (ABC) transporter Y11_06061 ENOG4105D5Q Arginine ornithine antiporter Y11_06081 ENOG4108WFR AraC Family Transcriptional Regulator Y11_06101 ENOG4105N4N Protein of unknown function (DUF2766) Y11_06111 ENOG4105TIK Y11_06131 ENOG41064PC Y11_06161 ENOG4105C85 amino acid Y11_06171 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) Y11_06181 ENOG410610J Protein of unknown function (DUF2627) Y11_06191 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Y11_06201 ENOG4105CJN penicillin-binding protein Y11_06211 ENOG4105CJN penicillin-binding protein Y11_06221 ENOG4105DHI Methyltransferase Y11_06241 ENOG4105BZU Histidine kinase Y11_06261 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) Y11_06271 ENOG4108NK4 UPF0266 membrane protein Y11_06281 ENOG4105F3R pts system mannose fructose sorbose family iid Y11_06291 ENOG4105ETZ PTS System Y11_06301 ENOG4108EQA pts system Y11_06321 ENOG4105EE5 Membrane protein terC Y11_06341 ENOG4105EJQ L-serine dehydratase Y11_06361 ENOG4105P8F nudix hydrolase Y11_06381 ENOG4105X5C UPF0181 protein Y11_06391 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Y11_06401 ENOG4105C1J atp-dependent rna helicase Y11_06411 ENOG4105X2V dna damage-inducible protein Y11_06421 ENOG4105N5Z UPF0267 protein Y11_06441 ENOG4105CUG Oligopeptidase b Y11_06451 ENOG4105UMD exodeoxyribonuclease X Y11_06481 ENOG4105MPK DNA polymerase III subunit theta Y11_06491 ENOG41090A1 ferritin Y11_06511 ENOG4105FXM Copper resistance protein Y11_06521 ENOG4108PNC copper resistance Y11_06531 ENOG4105NKT exported protein Y11_06541 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y11_06641 ENOG4105D5G Transposase Y11_06651 ENOG4108WF3 methyltransferase Y11_06661 ENOG4105D5G Transposase Y11_06681 ENOG4108HCJ Hydrolase Y11_06691 ENOG4106UW1 Major Facilitator superfamily Y11_06721 ENOG4105C85 amino acid Y11_06741 ENOG4108MRH transcriptional regulatory protein Y11_06751 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Y11_06761 ENOG4105MVE transcriptional regulator Y11_06771 ENOG4105G63 Type III effector Hrp-dependent Y11_06781 ENOG4105FB2 class II Aldolase Y11_06801 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) Y11_06811 ENOG4105CSV Glutaminase Y11_06841 ENOG4107SJW iron permease, FTR1 Y11_06871 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y11_06901 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y11_06941 ENOG4105EXG Transcriptional regulator Y11_06951 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Y11_06961 ENOG4108819 ferric iron reductase Y11_06971 ENOG4105H1N peptidase, M24 Y11_06981 ENOG4108TUY outer membrane protein PgaA Y11_06991 ENOG4108TUY outer membrane protein PgaA Y11_07001 ENOG4107BJW polysaccharide deacetylase Y11_07011 ENOG4105CND Glycosyl transferase, family 2 Y11_07021 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD Y11_07051 ENOG4105D5M phosphate starvation-inducible protein Y11_07081 ENOG4105C75 arginyL-tRNA synthetase Y11_07091 ENOG4106ZCM YecM protein Y11_07101 ENOG4106N3A copper homeostasis protein cutc Y11_07121 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_07131 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_07181 ENOG4105D64 Mechanosensitive ion channel Y11_07191 ENOG4108SHQ Glutathione S-transferase Y11_07251 ENOG4105WT8 Protein of unknown function (DUF1480) Y11_07331 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y11_07351 ENOG4105DY2 Paraquat-inducible protein b Y11_07361 ENOG4105H2K paraquat-inducible protein a Y11_07371 ENOG4108ZGC gaf domain protein Y11_07391 ENOG4105CN1 protease Y11_07401 ENOG4105D0M Protease HtpX homolog Y11_07421 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y11_07431 ENOG4105CAZ oligogalacturonide lyase Y11_07451 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase Y11_07491 ENOG4108ETY sodium dicarboxylate symporter Y11_07501 ENOG4107K5X Membrane-bound metal-dependent hydrolase Y11_07511 ENOG4108PU9 oligogalacturonate-specific porin Y11_07531 ENOG4105WEM extracellular solute-binding protein Y11_07541 ENOG4108IJ9 (ABC) transporter Y11_07551 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Y11_07561 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Y11_07571 ENOG41061NF Pectate lyase Y11_07591 ENOG4105CHR reductase Y11_07601 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) Y11_07611 ENOG4105M5J Cupin 2, conserved barrel domain protein Y11_07621 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 Y11_07631 ENOG4107PN8 YfeABCD locus regulator Y11_07641 ENOG4105DEQ transcriptional regulator Y11_07651 ENOG4105CYC Transferase Y11_07661 ENOG4108M7F enoyl-CoA hydratase isomerase Y11_07671 ENOG4105DJT lAO AO transport system ATPase Y11_07681 ENOG4105D5P Methylmalonyl-coA mutase Y11_07691 ENOG4105FGM Fructosamine kinase Y11_07701 ENOG4105CC5 ABC transporter Y11_07711 ENOG4105CC5 ABC transporter Y11_07721 ENOG4105DIK (ABC) transporter Y11_07731 ENOG4105DSE periplasmic solute binding protein Y11_07741 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Y11_07751 ENOG41082NP Multiple antibiotic resistance Y11_07821 ENOG4108UQV Membrane Y11_07831 ENOG41087WU Y11_07851 ENOG4105C22 threonyL-tRNA synthetase Y11_07861 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Y11_07871 ENOG41082NX 50s ribosomal protein l35 Y11_07881 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Y11_07891 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Y11_07911 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Y11_07951 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) Y11_07961 ENOG4108V06 Glutathione peroxidase Y11_07971 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) Y11_07981 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Y11_07991 ENOG4105CKK Glycosyl transferase, family 2 Y11_08001 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Y11_08011 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Y11_08021 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) Y11_08031 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) Y11_08041 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) Y11_08051 ENOG4108QBX (LipO)protein Y11_08061 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) Y11_08081 ENOG4107R4I Periplasmic binding protein Y11_08091 ENOG4106QJH hemin transport protein Y11_08101 ENOG4107ENK receptor Y11_08111 ENOG4107F3C Hemin uptake protein Y11_08121 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Y11_08131 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Y11_08141 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Y11_08151 ENOG4105IPI Membrane Y11_08161 ENOG4105CQB FAD linked oxidase domain protein Y11_08171 ENOG4105KA0 thioesterase Superfamily protein Y11_08181 ENOG4108Z4V iron-sulfur cluster assembly Y11_08191 ENOG4105DIW FeS assembly protein SUFB Y11_08201 ENOG4105C3K feS assembly ATPase SufC Y11_08211 ENOG4105JRK feS assembly protein SufD Y11_08231 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Y11_08241 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein Y11_08251 ENOG4105CA9 Pyruvate kinase Y11_08261 ENOG4107QI1 Mate efflux family protein Y11_08271 ENOG4108R6K riboflavin synthase, subunit alpha Y11_08281 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Y11_08291 ENOG4105CZQ inner membrane transport protein YdhC Y11_08301 ENOG4105F52 Transcriptional regulator Y11_08311 ENOG4105ETE Transcriptional regulator (LacI family Y11_08321 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Y11_08331 ENOG4105K4H Nlp p60 protein Y11_08341 ENOG4105M2J Glutaredoxin Y11_08351 ENOG4108UYE Lactoylglutathione lyase Y11_08361 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y11_08371 ENOG4108WUH Transcriptional regulator, TetR family Y11_08381 ENOG4105DIJ Phosphoethanolamine transferase Y11_08391 ENOG4105XZD Fe-S protein Y11_08401 ENOG4107RGM aldo keto reductase Y11_08411 ENOG4105DSW Fusaric acid resistance protein Y11_08421 ENOG4105Y49 secretion protein, HlyD family Y11_08441 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) Y11_08451 ENOG4108XTF Outer Membrane Lipoprotein Y11_08471 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Y11_08481 ENOG410642K Lysozyme inhibitor Y11_08491 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Y11_08501 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Y11_08521 ENOG4108K3A Glutathione S-transferase Y11_08531 ENOG4108ZR5 Conserved Protein Y11_08541 ENOG41069YE inner membrane protein yohC Y11_08571 ENOG4105DUX Transporter Y11_08591 ENOG4105DUM transcriptional regulator, lysR family Y11_08601 ENOG4105Q4T oxidoreductase Y11_08621 ENOG4108JQ2 peptide transport system atp-binding protein Y11_08631 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein Y11_08641 ENOG4108EU3 peptide transport system, permease Y11_08651 ENOG4108I5W peptide transport system, permease protein Y11_08661 ENOG4108HIY periplasmic Y11_08671 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_08681 ENOG4106DF6 pertussis toxin subunit 1 Y11_08701 ENOG4105E51 psp operon transcriptional activator Y11_08711 ENOG41087YS Phage shock protein A Y11_08721 ENOG4105YYT phage shock protein B Y11_08731 ENOG4105FM1 phage shock protein C Y11_08751 ENOG4105CM6 amino acid regulated cytosolic protein Y11_08761 ENOG4106K28 UPF0283 membrane protein Y11_08791 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Y11_08801 ENOG4107S8C mandelate racemase muconate lactonizing Y11_08811 ENOG4105KXI murein peptide amidase A Y11_08821 ENOG4107QSI ABC, transporter Y11_08831 ENOG4107RX3 Mg2 transporter protein cora family protein Y11_08841 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) Y11_08861 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C Y11_08871 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) Y11_08901 ENOG4105KT7 mgtC SapB transporter Y11_08921 ENOG4105C5I Dehydrogenase Y11_08931 ENOG4107H52 Dicarboxylate transport Y11_08941 ENOG410689M (LipO)protein Y11_08951 ENOG4105WXT Conserved Protein Y11_08961 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Y11_08971 ENOG4105CQ7 ATP-dependent helicase Y11_09001 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap Y11_09021 ENOG4105CTD carboxy-peptidase Y11_09041 ENOG4105JJR Histidine kinase Y11_09051 ENOG4107EXC regulatoR Y11_09071 ENOG4105D5Q Arginine ornithine antiporter Y11_09091 ENOG4105C5D exported protein Y11_09101 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Y11_09111 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Y11_09121 ENOG4105Q9Y Universal stress protein Y11_09131 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Y11_09141 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Y11_09171 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) Y11_09181 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Y11_09201 ENOG4108RVA ribokinase Y11_09211 ENOG4105EDR glucose galactose transporter Y11_09251 ENOG4105PAD Hydrolase Y11_09261 ENOG4105M71 acetolactate synthase 1 regulatory subunit Y11_09271 ENOG4105C7K acetolactate synthase Y11_09291 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase Y11_09391 ENOG4105ETE Transcriptional regulator (LacI family Y11_09411 ENOG4105FYV Amp nucleosidase Y11_09431 ENOG4107R3N Filamentation induced by cAMP protein fic Y11_09481 ENOG4106V2I dimethylaminohydrolase Y11_09501 ENOG4105DSP amino acid AbC transporter Y11_09521 ENOG4108RYR transcriptional regulator AsnC family Y11_09571 ENOG4105CYM Glutathione S-transferase Y11_09601 ENOG4105MQ5 zona occludens toxin Y11_09751 ENOG4105TDT uncharacterized protein yahO Y11_09781 ENOG4105EMU Dehydrogenase Y11_09791 ENOG4105KK4 UPF0060 membrane protein Y11_09811 ENOG4105M5Q UPF0482 protein Y11_09821 ENOG4105KBG Protein of unknown function (DUF1161) Y11_09851 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Y11_09861 ENOG4105DAG ROK family Y11_09871 ENOG4106NZI LysR family Transcriptional regulator Y11_09881 ENOG4105D94 Major Facilitator Superfamily Y11_09921 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) Y11_09941 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_09961 ENOG4105C9Q fumarate hydratase class II Y11_09971 ENOG4105EIP mannose-6-phosphate isomerase Y11_09981 ENOG4106J39 exported protein Y11_10001 ENOG4107P2S Transcriptional regulator Y11_10011 ENOG4105CI1 PTS System Y11_10021 ENOG4105C87 Aminotransferase class I and II Y11_10031 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Y11_10041 ENOG4105DHU Bile acid Y11_10051 ENOG4105D9R oxidoreductase Y11_10071 ENOG4105CNN ABC, transporter Y11_10081 ENOG4105CNN ABC, transporter Y11_10101 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator Y11_10121 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) Y11_10131 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Y11_10141 ENOG4108JJA ABC, transporter Y11_10161 ENOG4105C42 Type I secretion membrane fusion protein (HlyD Y11_10191 ENOG4105CKU formyltetrahydrofolate synthetase Y11_10201 ENOG4105M9B inner membrane protein ydgK Y11_10211 ENOG4105DGN Electron transport complex Y11_10231 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Y11_10261 ENOG4105UEI Transcriptional Regulator AraC Family Y11_10281 ENOG4105D6A Electron transport complex Y11_10291 ENOG4108UQQ Electron transport complex Y11_10311 ENOG4105CSM endonuclease III Y11_10341 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_10361 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit Y11_10381 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) Y11_10401 ENOG4105D22 carbon starvation protein Y11_10421 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Y11_10431 ENOG4105N2W Transcriptional regulator Y11_10451 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase Y11_10461 ENOG41061RM osmotically inducible lipoprotein Y11_10481 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_10491 ENOG4108ZJT translation initiation factor, Sui1 Y11_10501 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Y11_10511 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction Y11_10521 ENOG4105DKK Benzoate Y11_10531 ENOG4105DKK Benzoate Y11_10541 ENOG4108JCI Transcriptional regulator Y11_10561 ENOG4105CFV Tetratricopeptide repeat protein Y11_10571 ENOG4105Q4A inner membrane protein yciS Y11_10581 ENOG4105EYK Phosphatidylglycerophosphatase B Y11_10591 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) Y11_10601 ENOG4107QM5 aconitate hydratase Y11_10631 ENOG4107R11 Transcriptional regulator Y11_10641 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Y11_10661 ENOG4105RKX Protein of unknown function (DUF2498) Y11_10671 ENOG4105ERU peptidase Y11_10681 ENOG4105UBK short-chain dehydrogenase reductase Y11_10691 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Y11_10711 ENOG4105FE9 pseudouridine synthase Y11_10721 ENOG4107RTD sua5 ycio yrdc ywlc family protein Y11_10731 ENOG4105DB7 PHP domain protein Y11_10761 ENOG4105DDQ anthranilate synthase Y11_10781 ENOG4105DK0 Indole-3-glycerol phosphate synthase Y11_10791 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Y11_10801 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Y11_10821 ENOG4105EIF outer membrane protein W Y11_10831 ENOG4105PI0 Ferredoxin Y11_10841 ENOG4108S3I UPF0259 membrane protein Y11_10861 ENOG4107835 probably involved in intracellular septation (By similarity) Y11_10871 ENOG4105NAU thioesterase Superfamily protein Y11_10881 ENOG410822N TonB family Y11_10891 ENOG4105K9H YciI-like protein Y11_10931 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Y11_10941 ENOG4108W5H UPF0263 protein Y11_10951 ENOG4108JQ7 (ABC) transporter Y11_10961 ENOG4105C3U ABC transporter Y11_10971 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Y11_10981 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Y11_10991 ENOG4107QSI ABC, transporter Y11_11001 ENOG4107QSI ABC, transporter Y11_11011 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Y11_11021 ENOG4108EKI Dehydrogenase Y11_11031 ENOG4107104 thymidine kinase Y11_11051 ENOG4105C6Y Udp-glucose 6-dehydrogenase Y11_11061 ENOG4105I93 response regulator Y11_11071 ENOG4105I93 response regulator Y11_11081 ENOG4105D78 K07001 NTE family protein Y11_11121 ENOG4105K5B UPF0225 protein Y11_11131 ENOG4105CIY formyltetrahydrofolate deformylase Y11_11141 ENOG4105SKE transcriptional Regulator LysR family Y11_11161 ENOG4105CGK Exodeoxyribonuclease III Y11_11171 ENOG4105M6F mutator MutT protein Y11_11191 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Y11_11211 ENOG41069NU Nitroreductase Y11_11221 ENOG4105D07 Signal peptide peptidase, SppA Y11_11231 ENOG4105HDK L-asparaginase Y11_11241 ENOG4108RWI nicotinamidase Y11_11261 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_11271 ENOG4105VUT cytoplasmic protein Y11_11281 ENOG4105E0X reductase Y11_11311 ENOG4105DSB aldose 1-epimerase Y11_11321 ENOG4105GNX MltA-interacting MipA family protein Y11_11331 ENOG4105CYN Serine protein kinase Y11_11341 ENOG4106AKX UPF0229 protein Y11_11371 ENOG4105HEI LysR family (Transcriptional regulator Y11_11381 ENOG4105EUB pirin domain protein Y11_11391 ENOG4105BZU Histidine kinase Y11_11401 ENOG4105CNH Multidrug resistance protein MdtL Y11_11411 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Y11_11421 ENOG4105MWK D-amino acid dehydrogenase, small subunit Y11_11441 ENOG4105ED1 spovr family Y11_11451 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) Y11_11471 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Y11_11491 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) Y11_11521 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_11541 ENOG4108ZZ3 UPF0260 protein Y11_11551 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase Y11_11561 ENOG4105CVE Lytic murein transglycosylase Y11_11571 ENOG4105VNG YcgL domain-containing protein Y11_11591 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Y11_11601 ENOG4107QMS site-determining protein Y11_11611 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) Y11_11621 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Y11_11631 ENOG4105CEY Amp-dependent synthetase and ligase Y11_11641 ENOG4105Y4Z Outer Membrane Lipoprotein Y11_11651 ENOG41072GX Peptidase M22 Glycoprotease Y11_11661 ENOG4105DVT helicase Y11_11671 ENOG4105M4H endoribonuclease L-psp Y11_11691 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) Y11_11711 ENOG4108UHU Aldolase Y11_11721 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Y11_11731 ENOG4106KNT transcriptional regulator Y11_11741 ENOG4105CA9 Pyruvate kinase Y11_11761 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase Y11_11771 ENOG4105DR5 peptidase Y11_11781 ENOG4105NXV High-affinity zinc uptake system protein Y11_11791 ENOG4105FDK ABC transporter Y11_11801 ENOG4105FAV ABC, transporter Y11_11811 ENOG4105DUX Transporter Y11_11821 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Y11_11831 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Y11_11841 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Y11_11851 ENOG4105CDY transcriptional regulatory protein Y11_11861 ENOG4108TIT dATP pyrophosphohydrolase Y11_11871 ENOG4105C9M aspartyl-trna synthetase Y11_11901 ENOG4105D3W isochorismatase Y11_11911 ENOG41081XQ Conserved Protein Y11_11921 ENOG4105WJG Glutathione Y11_11931 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) Y11_11941 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Y11_11961 ENOG4105E98 transcriptional regulator DeoR family Y11_11971 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of Y11_11981 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB Y11_12001 ENOG4105F3R pts system mannose fructose sorbose family iid Y11_12011 ENOG4108YTN IIa component Y11_12021 ENOG4105E70 isomerase Y11_12031 ENOG4105D2N Aldolase Y11_12051 ENOG4108K5P (LipO)protein Y11_12121 ENOG4108MEK Metal-binding protein YodA Y11_12131 ENOG41090B9 response to stress Y11_12141 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) Y11_12151 ENOG4105CZE histidine utilization repressor Y11_12161 ENOG4105CI2 imidazolone-5-propionate hydrolase Y11_12211 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_12221 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) Y11_12231 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) Y11_12241 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) Y11_12261 ENOG4105F4X arginine Y11_12271 ENOG4105C8Y Acetylornithine aminotransferase Y11_12281 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y11_12291 ENOG4105C4M (Ubiquinol oxidase) subunit I Y11_12301 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Y11_12321 ENOG4105BZU Histidine kinase Y11_12331 ENOG4107R11 Transcriptional regulator Y11_12341 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_12351 ENOG4105F27 Major Facilitator Y11_12371 ENOG4105EWV Sodium calcium exchanger membrane region Y11_12381 ENOG4105CJR Integral membrane protein (MviN Y11_12391 ENOG4105EP9 oxidoreductase Y11_12411 ENOG4105D9U N-acetyltransferase Y11_12431 ENOG4105EV4 Multidrug resistance protein mdtH Y11_12441 ENOG4105F3T (LipO)protein Y11_12451 ENOG4107XHZ cytoplasmic chaperone TorD family protein Y11_12461 ENOG4107SSZ Phosphatase Y11_12471 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Y11_12491 ENOG4105BZU Histidine kinase Y11_12501 ENOG4105CHH sulfate transporter Y11_12511 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Y11_12521 ENOG41063JG Transcriptional regulator Y11_12531 ENOG4108YY7 Invasion gene expression up-regulator SirB Y11_12541 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Y11_12551 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Y11_12561 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Y11_12571 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) Y11_12591 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Y11_12601 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria Y11_12621 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Y11_12641 ENOG4105C3G gtp-binding protein Y11_12651 ENOG41066YJ Beta-lactamase Y11_12671 ENOG4108Q2J Inner membrane protein YebE Y11_12701 ENOG4105KUS lysozyme Y11_12711 ENOG4105HRS Antitermination protein Y11_12751 ENOG4105EXG Transcriptional regulator Y11_13051 ENOG4105D5G Transposase Y11_13091 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y11_13111 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Y11_13181 ENOG4105VZ1 Replication Protein Y11_13221 ENOG4105ED4 portal protein Y11_13511 ENOG4105ZTC transcriptional activator, Ogr delta Y11_13531 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Y11_13541 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Y11_13551 ENOG4105WH1 Two component transcriptional regulator luxr family Y11_13561 ENOG4105XVG cytoplasmic protein Y11_13571 ENOG4105RA2 Membrane Y11_13591 ENOG4105E5K Alpha-amylase Y11_13621 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Y11_13651 ENOG4105C85 amino acid Y11_13661 ENOG4108R86 Transcriptional regulator Y11_13681 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) Y11_13691 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) Y11_13701 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) Y11_13711 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Y11_13721 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Y11_13731 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) Y11_13741 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) Y11_13751 ENOG4105C2W permease Y11_13761 ENOG4105C2W permease Y11_13781 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) Y11_13801 ENOG4105CS1 NAD(P)H quinone oxidoreductase Y11_13861 ENOG4105GMB type VI secretion system effector, hcp1 family Y11_13901 ENOG4105CK7 Sodium proline symporter Y11_13911 ENOG4105C26 Dehydrogenase Y11_13941 ENOG4105CDA abc transporter atp-binding protein Y11_13951 ENOG4105E5Q amino acid AbC transporter Y11_13961 ENOG4105EAB amino acid AbC transporter Y11_13971 ENOG4105K6H D-cysteine desulfhydrase Y11_13991 ENOG4108M9K flagella biosynthesis protein FliZ Y11_14001 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y11_14011 ENOG4108C80 FliB family Y11_14021 ENOG4105I03 Flagellin Y11_14061 ENOG4105I03 Flagellin Y11_14071 ENOG4105DTS flagellar hook-associated Y11_14081 ENOG4105MQ3 flagellar protein FliS Y11_14091 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) Y11_14111 ENOG4105DHT Metal Dependent Phosphohydrolase Y11_14181 ENOG4107R08 Integrase Y11_14191 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Y11_14201 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Y11_14211 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Y11_14221 ENOG41090PJ Flagellar assembly protein Y11_14231 ENOG4108JIR Flagellum-specific ATP synthase Y11_14241 ENOG4105GSA Flagellar export protein flij Y11_14251 ENOG4105WF4 Flagellar hook-length control protein Y11_14261 ENOG4107ZI8 flagellar basal body-associated protein flil Y11_14271 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Y11_14281 ENOG4105DD5 Flagellar motor switch protein Y11_14301 ENOG4105CN7 Flagellar biosynthetic protein FliP Y11_14311 ENOG4105VS8 Flagellar biosynthetic protein fliq Y11_14321 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Y11_14331 ENOG4105DTJ flagellar hook-associated protein Y11_14351 ENOG4105E1Q flagellar hook-associated protein Y11_14361 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Y11_14391 ENOG4105CGA flagellar basal-body rod protein FlgG Y11_14401 ENOG4108KPB Flagellar basal-body rod protein FlgF Y11_14411 ENOG4105BZE flagellar hook protein, FlgE Y11_14421 ENOG4105W00 Flagellar hook capping protein Y11_14431 ENOG4108ZC9 flagellar basal-body rod protein flgc Y11_14441 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Y11_14451 ENOG4105CKS Flagella basal body P-ring formation protein flgA Y11_14461 ENOG4105M9M anti-sigma28 factor FlgM Y11_14471 ENOG4105QVD Flagella synthesis protein FlgN Y11_14481 ENOG4105TNG K13735 adhesin invasin Y11_14491 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_14511 ENOG4105W13 flagellar protein Y11_14521 ENOG4105D7B Flagellar biosynthesis protein flha Y11_14531 ENOG4105D00 flagellar biosynthetic protein flhB Y11_14541 ENOG4107VE4 peptidase S8 and S53, subtilisin, kexin, sedolisin Y11_14551 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) Y11_14561 ENOG4108VYJ response regulator receiver protein Y11_14581 ENOG4105BZU Histidine kinase Y11_14591 ENOG4105C8Q Methyl-accepting chemotaxis Y11_14601 ENOG4105C8Q Methyl-accepting chemotaxis Y11_14621 ENOG4108V3W Chemotaxis protein, CheW Y11_14641 ENOG4105CBS Chea signal transduction histidine kinase Y11_14651 ENOG4105ER2 Ompa motb domain protein Y11_14661 ENOG4107RD7 Flagellar Motor Protein, MotA Y11_14681 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region Y11_14691 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) Y11_14701 ENOG4108VA4 Universal stress protein Y11_14711 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Y11_14721 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Y11_14731 ENOG4105KT7 mgtC SapB transporter Y11_14761 ENOG4105C8Q Methyl-accepting chemotaxis Y11_14771 ENOG4105VZF DsrB protein Y11_14791 ENOG4105VEQ Cold shock protein Y11_14801 ENOG4105ETE Transcriptional regulator (LacI family Y11_14811 ENOG4105CNT hydrolase family 2 Y11_14821 ENOG4105D5G Transposase Y11_14841 ENOG4105GSJ Inner membrane protein ylaC Y11_14881 ENOG41061EV selenium-binding protein YdfZ Y11_14891 ENOG4105D6F Phosphatase Y11_14901 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Y11_14931 ENOG4108S1B Periplasmic chaperone protein Y11_14941 ENOG4108D1K outer membrane usher protein Y11_14981 ENOG4105CMG Carbohydrate kinase Y11_15001 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) Y11_15021 ENOG4107RSM transcriptional regulator Y11_15131 ENOG4108Q9V regulatoR Y11_15141 ENOG4105BZU Histidine kinase Y11_15191 ENOG4108VCD Chaperone Y11_15221 ENOG4105D3G Pseudouridine synthase Y11_15231 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme Y11_15241 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein Y11_15251 ENOG4105C54 Major Facilitator superfamily Y11_15271 ENOG4108TSE Transferase Y11_15281 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Y11_15301 ENOG4105CG6 trap dicarboxylate transporter dctm subunit Y11_15311 ENOG4107QPK )-transporter Y11_15321 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase Y11_15331 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase Y11_15341 ENOG4105CHY citrate lyase, alpha Y11_15351 ENOG4105CI0 Citrate lyase Y11_15361 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) Y11_15371 ENOG4105DUA (citrate (pro-3S)-lyase ligase Y11_15381 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Y11_15391 ENOG4106YYS transcriptional regulatory protein Y11_15401 ENOG4108KX4 response regulator Y11_15411 ENOG4105BZU Histidine kinase Y11_15421 ENOG4105CXY transporter Y11_15431 ENOG4105C4Y ABC transporter Y11_15441 ENOG4107RCV ABC transporter, permease Y11_15451 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y11_15501 ENOG4107R88 Chemotaxis protein (CheV) Y11_15511 ENOG4107S1E Beta-lactamase Y11_15521 ENOG4105E98 transcriptional regulator DeoR family Y11_15531 ENOG410667J hydrolase Y11_15541 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Y11_15571 ENOG4105UQX Mate efflux family protein Y11_15581 ENOG4105CDH Citrulline--aspartate ligase Y11_15631 ENOG4105CS6 Rhs element vgr protein Y11_15721 ENOG4105CW0 outer membrane usher protein Y11_15731 ENOG4108VEV chaperone Y11_15751 ENOG4106EAR Fimbrial protein Y11_15761 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y11_15881 ENOG4105EAA nucleoside Y11_15901 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Y11_15911 ENOG4108TGR phosphatase Y11_15921 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) Y11_15931 ENOG4108YZT Adenosylcobinamide kinase Y11_15941 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Y11_15961 ENOG4108V4M Cobalt abc transporter Y11_15971 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Y11_15981 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Y11_15991 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Y11_16001 ENOG4105DVK Precorrin-2 c20-methyltransferase Y11_16011 ENOG4107PPM cobalt chelatase Y11_16021 ENOG4105QUC reductase Y11_16031 ENOG4105E4R Precorrin-3B C17-methyltransferase Y11_16041 ENOG4108P62 biosynthesis protein (CbiG) Y11_16051 ENOG4105CIA precorrin-4 C(11)-methyltransferase Y11_16061 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase Y11_16071 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase Y11_16081 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Y11_16091 ENOG41081F0 Precorrin-8x methylmutase Y11_16101 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Y11_16111 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Y11_16131 ENOG4107XVH Transcriptional regulator Y11_16141 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Y11_16151 ENOG4105KNY Microcompartments protein Y11_16161 ENOG4105EHR propanediol utilization protein pduB Y11_16171 ENOG4105DMB glycerol dehydratase Y11_16181 ENOG4105YCI dehydratase medium subunit Y11_16191 ENOG4108ZFT Dehydratase small subunit Y11_16201 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit Y11_16221 ENOG4105KNY Microcompartments protein Y11_16241 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) Y11_16261 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml Y11_16281 ENOG4108EKI Dehydrogenase Y11_16301 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) Y11_16321 ENOG4105M3W utilization protein Y11_16331 ENOG4105KTW ethanolamine utilization protein Y11_16341 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Y11_16351 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y11_16361 ENOG4107QZB decarboxylase Y11_16371 ENOG4105JZC GHMP kinase Y11_16381 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Y11_16391 ENOG4105C2J ABC transporter Y11_16401 ENOG4105CNN ABC, transporter Y11_16421 ENOG41090HJ UPF0265 protein Y11_16431 ENOG4105DR8 Membrane Y11_16441 ENOG4105E4E Thioester reductase domain-containing protein Y11_16451 ENOG4105CJB Exodeoxyribonuclease I Y11_16461 ENOG4105CUB amino acid Y11_16471 ENOG4107SCQ Iron-containing alcohol dehydrogenase Y11_16481 ENOG4105C2J ABC transporter Y11_16491 ENOG4105C2J ABC transporter Y11_16501 ENOG4105CNN ABC, transporter Y11_16511 ENOG4108535 NAD dependent epimerase/dehydratase family Y11_16521 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Y11_16541 ENOG4105CIH Imidazole acetol-phosphate transaminase Y11_16551 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Y11_16561 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Y11_16571 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Y11_16581 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Y11_16591 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Y11_16601 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Y11_16621 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Y11_16631 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Y11_16711 ENOG4107RGC Glycosyl transferase, family 2 Y11_16731 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Y11_16811 ENOG4105EE5 Membrane protein terC Y11_16821 ENOG4105CEE C4-dicarboxylate transporter Y11_16831 ENOG4108GAE asmA family Y11_16851 ENOG4105DBI uridine monophosphokinase Y11_16861 ENOG4105D1F ATP-binding protein Y11_16881 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Y11_16921 ENOG4105E5W Transporter Y11_16931 ENOG4105VAW lrga family Y11_16941 ENOG41067MG lrgb family Y11_16961 ENOG4107R1I NAD-dependent malic enzyme Y11_16971 ENOG4107GZ4 SanA protein Y11_16991 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Y11_17001 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) Y11_17011 ENOG4108JPZ Monovalent cation H antiporter subunit D Y11_17021 ENOG4107TDF Formate hydrogenlyase subunit 4 Y11_17031 ENOG4107TDF Formate hydrogenlyase subunit 4 Y11_17041 ENOG4105D65 subunit l Y11_17051 ENOG4107WQX hydrogenase 4 membrane subunit Y11_17061 ENOG4108JPZ Monovalent cation H antiporter subunit D Y11_17071 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Y11_17091 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Y11_17101 ENOG4105I6X formate hydrogenlyase maturation Y11_17111 ENOG4108MG9 hydrogenase 3 maturation protease Y11_17121 ENOG4108RC0 Electron transport protein Y11_17131 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Y11_17141 ENOG4108JUA Transcriptional regulator Y11_17151 ENOG4107SDZ Galactoside transport system permease protein mglC Y11_17181 ENOG41060NJ transcriptional regulator Y11_17201 ENOG4105DHF Membrane Y11_17211 ENOG4105EUJ GTP cyclohydrolase i Y11_17221 ENOG4105CBP Major Facilitator Y11_17231 ENOG4105EGI Transcriptional regulator Y11_17291 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y11_17321 ENOG4105CVM Molybdenum cofactor synthesis domain protein Y11_17331 ENOG4105D06 uba thif-type nad fad binding protein Y11_17351 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_17361 ENOG4105C5H ABC transporter Y11_17401 ENOG4108T1M outer membrane protein x Y11_17461 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Y11_17471 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Y11_17481 ENOG4105KSC Transcriptional regulator, TraR DksA family Y11_17501 ENOG4107R0W ABC transporter Y11_17511 ENOG4105E5Q amino acid AbC transporter Y11_17521 ENOG4105CDA abc transporter atp-binding protein Y11_17531 ENOG4107SDU Methyl-accepting chemotaxis Y11_17551 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) Y11_17611 ENOG4108MTB glycosyl transferase family Y11_17621 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Y11_17631 ENOG4105DVT helicase Y11_17671 ENOG4105FDR Membrane Y11_17691 ENOG4105HEI LysR family (Transcriptional regulator Y11_17701 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Y11_17721 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component Y11_17731 ENOG4108IJ8 ABC transporter Y11_17741 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component Y11_17751 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system Y11_17771 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Y11_17781 ENOG4105KHC sulfurtransferase Y11_17791 ENOG4108IV0 ABC, transporter Y11_17801 ENOG4105D5T phosphonate abc transporter Y11_17811 ENOG4105CNN ABC, transporter Y11_17821 ENOG4105C32 Amino acid ABC transporter (Permease) Y11_17841 ENOG4108W15 Protein of unknown function (DUF1456) Y11_17871 ENOG4105EHI Phosphonate ABC transporter, periplasmic Y11_17891 ENOG4105Y3U Transglycosylase-associated protein Y11_17911 ENOG4105N1F Hnh endonuclease Y11_17931 ENOG4105CXG d-lactate dehydrogenase Y11_17941 ENOG41061WM D-Alanyl-D-Alanine Y11_17961 ENOG4105CJW magnesium transporter Y11_17981 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) Y11_17991 ENOG4105C1J atp-dependent rna helicase Y11_18001 ENOG4107MVR Transcriptional regulator Y11_18011 ENOG4105D0S secretion protein (HlyD Y11_18021 ENOG4105CJ1 ABC, transporter Y11_18031 ENOG4107QWP ABC-2 type transporter Y11_18041 ENOG4107QWP ABC-2 type transporter Y11_18051 ENOG4105HFZ Membrane Y11_18061 ENOG4108ZAF Molybdopterin Y11_18071 ENOG4105M00 molybdopterin converting factor, subunit 1 Y11_18081 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Y11_18091 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Y11_18101 ENOG4105CHW UPF0052 protein Y11_18111 ENOG4105VYA Uncharacterized conserved protein (DUF2132) Y11_18121 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Y11_18151 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Y11_18161 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Y11_18171 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Y11_18181 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Y11_18201 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Y11_18211 ENOG4108K4B hydrolase Y11_18231 ENOG4105E0C molybdate abc transporter Y11_18241 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Y11_18251 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Y11_18261 ENOG410680R Protein of unknown function (DUF2592) Y11_18271 ENOG4105F4R Transcriptional regulator mode Y11_18291 ENOG4105DKW ABC transporter Y11_18311 ENOG4105CMR udp-glucose 4-epimerase Y11_18321 ENOG4105F0Z galactose-1-phosphate uridylyltransferase Y11_18331 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Y11_18341 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Y11_18401 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Y11_18411 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Y11_18421 ENOG4105PGM cation diffusion facilitator family transporter Y11_18431 ENOG4106Z1T Nicotinamide Mononucleotide Transporter Y11_18441 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Y11_18451 ENOG4105UFD tol-pal system protein YbgF Y11_18461 ENOG4105KCK Peptidoglycan-associated lipoprotein Y11_18471 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Y11_18481 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA Y11_18481 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA Y11_18491 ENOG4105M8F Biopolymer transport protein exbD tolR Y11_18501 ENOG4105E02 MotA TolQ exbB proton channel Y11_18511 ENOG4107YD3 Thioesterase Y11_18521 ENOG4105KJB cyd operon protein YbgE Y11_18541 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Y11_18551 ENOG4105C4M (Ubiquinol oxidase) subunit I Y11_18561 ENOG4105CGH 5'-nucleotidase Y11_18571 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Y11_18581 ENOG4105CMV Succinyl-CoA synthetase subunit beta Y11_18591 ENOG4105C7S Dehydrogenase Y11_18601 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Y11_18611 ENOG4105E33 succinate dehydrogenase Y11_18631 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein Y11_18641 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit Y11_18651 ENOG4105BZN citrate synthase Y11_18661 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Y11_18691 ENOG4105E7W lamb ycsf family protein Y11_18701 ENOG4107R7A Allophanate hydrolase subunit 2 Y11_18711 ENOG4105P4J Allophanate hydrolase, subunit 1 Y11_18721 ENOG4107QNR UPF0135 protein Y11_18731 ENOG4107RF4 Phosphodiesterase Y11_18741 ENOG4105CVP deoxyribo-dipyrimidine photolyase Y11_18751 ENOG4107SEY Conserved Protein Y11_18761 ENOG4105EUK rtx toxin RtxA Y11_18761 ENOG4105EUK rtx toxin RtxA Y11_18771 ENOG4108RC6 RTX toxin Y11_18791 ENOG4105XIQ Protein of unknown function (DUF2517) Y11_18801 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Y11_18811 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Y11_18821 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Y11_18831 ENOG4105C08 Histidine kinase Y11_18841 ENOG4105EEX Two component transcriptional regulator (Winged helix family Y11_18871 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 Y11_18891 ENOG4105EV9 Alpha Beta Hydrolase Y11_18901 ENOG4105NNH LexA regulated protein Y11_18911 ENOG4105C8Q Methyl-accepting chemotaxis Y11_18921 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) Y11_18931 ENOG41090R7 Ferric uptake Y11_18951 ENOG4105GX6 (LipO)protein Y11_18971 ENOG4105CX6 glutaminyL-tRNA synthetase Y11_18981 ENOG4105CI1 PTS System Y11_18991 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Y11_19001 ENOG4105CE4 GlcNAc 6-P deacetylase Y11_19011 ENOG4105E2R ROK family Y11_19031 ENOG4105D4U had-superfamily hydrolase, subfamily iia Y11_19041 ENOG4105CAQ asparagine synthetase Y11_19051 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family Y11_19061 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Y11_19071 ENOG4105C9A Phoh family Y11_19081 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Y11_19091 ENOG4108JU5 Magnesium and cobalt efflux protein Y11_19101 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Y11_19121 ENOG4107RP9 extracellular solute-binding protein, family 3 Y11_19131 ENOG4105EAD ABC transporter Y11_19141 ENOG4105DRP amino acid AbC transporter Y11_19151 ENOG4105CDA abc transporter atp-binding protein Y11_19161 ENOG4107PAI alpha helical protein Y11_19181 ENOG4105C8T Leucyl-tRNA synthetase Y11_19191 ENOG4108U2H Rare lipoprotein B Y11_19201 ENOG4105DJF DNA polymerase III, delta' subunit Y11_19211 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Y11_19221 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Y11_19241 ENOG4105CJN penicillin-binding protein Y11_19251 ENOG4105CNI cell division protein FtsW Y11_19261 ENOG4105K6T rare lipoprotein A Y11_19271 ENOG4105DZ1 carboxypeptidase Y11_19281 ENOG4108Z43 UPF0250 protein Y11_19291 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Y11_19301 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Y11_19311 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) Y11_19321 ENOG4105BZU Histidine kinase Y11_19331 ENOG4107Z6W Protein CrcB homolog Y11_19341 ENOG4105VEQ Cold shock protein Y11_19361 ENOG4108N8T regulatoR Y11_19381 ENOG4108R1E Serine threonine protein phosphatase 1 Y11_19411 ENOG4108JJ7 ABC transporter Y11_19431 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Y11_19441 ENOG4105C84 Histidine ammonia-lyase Y11_19451 ENOG4105EZE Cupin 4 family protein Y11_19481 ENOG4108KU3 Integrase Y11_19591 ENOG4108MIB Y11_19641 ENOG4105DFP Integrase Y11_19651 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Y11_19661 ENOG4105WQ3 Rna-binding protein Y11_19671 ENOG4105C8N cysteinyl-tRNA synthetase Y11_19681 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Y11_19691 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) Y11_19701 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Y11_19711 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Y11_19721 ENOG4105CV6 ABC transporter, permease Y11_19731 ENOG4105CV6 ABC transporter, permease Y11_19741 ENOG4108I0Y (ABC) transporter Y11_19751 ENOG4108UJV acyl-CoA thioesterase i Y11_19761 ENOG4105E1F short-chain dehydrogenase reductase Y11_19771 ENOG4107QR8 Thioredoxin Y11_19781 ENOG4107QX8 SPFH domain, Band 7 family protein Y11_19791 ENOG4105G5H Membrane Y11_19801 ENOG4108Z6Z Transcriptional regulator Y11_19811 ENOG4105C59 p-type ATPase Y11_19821 ENOG4105MBR gumn family Y11_19831 ENOG4108Z66 YbaK ebsC protein Y11_19841 ENOG4105CGH 5'-nucleotidase Y11_19861 ENOG4105EU0 Major facilitator Superfamily Y11_19891 ENOG4105CKD glutathione-regulated potassium-efflux system protein Y11_19901 ENOG4107RE1 Inosine-guanosine kinase Y11_19911 ENOG4105CMR udp-glucose 4-epimerase Y11_19941 ENOG4105ESV Glycosyl transferase, family 4 Y11_19951 ENOG4107RJ7 Glycosyl transferase (Group 1 Y11_19961 ENOG4105CG5 Glycosyl transferase (Group 1 Y11_19971 ENOG4108SHN Glycosyl transferase, family 2 Y11_19991 ENOG4105ER6 polysaccharide biosynthesis protein Y11_20001 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Y11_20011 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Y11_20031 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Y11_20041 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Y11_20051 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Y11_20061 ENOG4107QMP dna polymerase iii subunits gamma and tau Y11_20071 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Y11_20101 ENOG4106428 Protein of unknown function (DUF2496) Y11_20111 ENOG4105EGS Mechanosensitive ion channel Y11_20121 ENOG41090EX DsrE family Y11_20131 ENOG4108IG5 Transcriptional regulator Y11_20141 ENOG4105C1P efflux transporter, rnd family, mfp subunit Y11_20151 ENOG4105BZS acriflavin resistance protein Y11_20211 ENOG4108626 Racemase Y11_20221 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Y11_20231 ENOG4105MUZ Protein of unknown function DUF2620 Y11_20241 ENOG4106M0N transport system permease protein Y11_20251 ENOG4105NRA 50s ribosomal protein l31 type b Y11_20261 ENOG4105YK5 50S ribosomal protein L36 Y11_20271 ENOG4105DSE periplasmic solute binding protein Y11_20281 ENOG4105CC5 ABC transporter Y11_20291 ENOG4105DIK (ABC) transporter Y11_20321 ENOG4108UKR Biofilm formation regulator YbaJ Y11_20331 ENOG4105KF5 hemolysin expression-modulating protein Y11_20351 ENOG41080UX Methyltransferase Y11_20361 ENOG4108MNP Glycoprotein polysaccharide metabolism Y11_20371 ENOG4105C29 acyl-CoA thioesterase Y11_20381 ENOG4105BZU Histidine kinase Y11_20391 ENOG4108YZA Nitrogen regulatory protein pii Y11_20401 ENOG4105BZ1 (ABC) transporter Y11_20411 ENOG4105BZ1 (ABC) transporter Y11_20421 ENOG4108XM1 transcriptional regulator AsnC family Y11_20441 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) Y11_20451 ENOG4108NFA extracellular solute-binding protein Y11_20461 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Y11_20471 ENOG4108TGP Thioesterase superfamily protein Y11_20481 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein Y11_20491 ENOG4105EIN peptidylprolyl cis-trans isomerase Y11_20511 ENOG4105K70 DNA-binding protein Y11_20521 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Y11_20541 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Y11_20551 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Y11_20561 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Y11_20571 ENOG4105M85 Bola protein Y11_20581 ENOG4105IEY (LipO)protein Y11_20591 ENOG4105EYM Major Facilitator superfamily Y11_20601 ENOG4108NFH Sugar hydrolase Y11_20611 ENOG4105E2S oxidase) subunit II Y11_20621 ENOG4105BZ9 Cytochrome C oxidase, subunit I Y11_20631 ENOG4105CCU oxidase (Subunit III) Y11_20641 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Y11_20651 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Y11_20661 ENOG4107RDB Major Facilitator Y11_20671 ENOG4108VPT UPF0234 protein Y11_20681 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Y11_20691 ENOG4107S0N DJ-1 family Y11_20701 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Y11_20721 ENOG4105CTB Polyprenyl synthetase Y11_20731 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Y11_20741 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_20751 ENOG4108ZAI phosphatidylglycerophosphatase a Y11_20761 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Y11_20771 ENOG4107YIM Involved in the transcription termination process (By similarity) Y11_20781 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Y11_20791 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Y11_20801 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Y11_20831 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_20841 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Y11_20851 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Y11_20861 ENOG4105VIE preprotein translocase, subunit YajC Y11_20871 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Y11_20891 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_20911 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Y11_20931 ENOG4108ZYK Acyl carrier protein phosphodiesterase Y11_20941 ENOG4105D3R alkyl hydroperoxide reductase Y11_20971 ENOG4105CHR reductase Y11_20981 ENOG4107R28 alpha amylase, catalytic region Y11_20991 ENOG4105C85 amino acid Y11_21001 ENOG4105CWM branched-chain amino acid transport system II carrier protein Y11_21021 ENOG4105BZU Histidine kinase Y11_21031 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Y11_21041 ENOG4107RH8 nuclease SbcCD subunit D Y11_21051 ENOG4105EYH Exonuclease Y11_21061 ENOG4105DKQ ROK family Y11_21071 ENOG4105DH7 May be involved in recombination (By similarity) Y11_21081 ENOG4105NBK UPF0345 protein Y11_21101 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Y11_21171 ENOG4105F2W methyltransferase Y11_21211 ENOG4105E2V Glycosyltransferase 36 Y11_21231 ENOG4105F8D glycoside hydrolase family 4 Y11_21241 ENOG4105CI1 PTS System Y11_21251 ENOG4105FDP GntR family transcriptional regulator Y11_21261 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Y11_21271 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Y11_21281 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) Y11_21291 ENOG4105V1F Fermentation respiration switch protein Y11_21301 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Y11_21321 ENOG4105CIN aminoacyl-histidine dipeptidase Y11_21331 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Y11_21361 ENOG4105WWK YheO domain protein Y11_21371 ENOG4105CPF Cell wall formation (By similarity) Y11_21401 ENOG4105CJ2 (LipO)protein Y11_21411 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) Y11_21421 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y11_21431 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y11_21441 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y11_21451 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y11_21461 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) Y11_21471 ENOG4105F7V ErfK ybiS ycfS ynhG family protein Y11_21481 ENOG4105E7A Glutamine amidotransferase Y11_21501 ENOG4107QPN acyl-Coa dehydrogenase Y11_21511 ENOG4106YJS accessory processing protein Y11_21561 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) Y11_21581 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Y11_21591 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) Y11_21601 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) Y11_21611 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) Y11_21621 ENOG4105CHM Aminotransferase Y11_21651 ENOG4105C5R Aminotransferase Y11_21671 ENOG4105E5Q amino acid AbC transporter Y11_21681 ENOG4105E5Q amino acid AbC transporter Y11_21711 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Y11_21761 ENOG4105EQ0 Major Facilitator superfamily Y11_21771 ENOG4108UMN azlc family Y11_21781 ENOG4105ZED uncharacterized protein ygaH Y11_21791 ENOG4105NTK Transcriptional repressor Mpra Y11_21801 ENOG4105ETP RND efflux system, outer membrane lipoprotein Y11_21811 ENOG4105CW7 secretion protein, HlyD family Y11_21821 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y11_21831 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_21841 ENOG4105EIB trna rrna methyltransferase Y11_21851 ENOG4105K63 Thioredoxin Y11_21861 ENOG4106IUH DTW domain containing protein Y11_21871 ENOG4105CD5 CoA-binding domain protein Y11_21881 ENOG4105JIM Phosphatidylserine synthase Y11_21891 ENOG4105T42 (LipO)protein Y11_21901 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA Y11_21911 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Y11_21921 ENOG4105C34 Pseudouridine synthase Y11_21931 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Y11_21941 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Y11_21961 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_21971 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_21981 ENOG4105CQC Prephenate dehydratase Y11_21991 ENOG4105EHE chorismate mutase- prephenate dehydrogenase Y11_22001 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) Y11_22011 ENOG4108NEV two component transcriptional regulator, LytTR family Y11_22021 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Y11_22031 ENOG4108NE3 Salt-induced outer membrane protein Y11_22041 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Y11_22051 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Y11_22061 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Y11_22071 ENOG4105K5M 30s ribosomal protein S16 Y11_22081 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Y11_22091 ENOG4106KVJ cytochrome C assembly protein Y11_22101 ENOG4108JU6 CBS domain protein Y11_22111 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) Y11_22121 ENOG4105D9M gamma-glutamylcysteine synthetase Y11_22131 ENOG4105W39 Membrane Y11_22141 ENOG4107VXZ Hydrolase Y11_22151 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Y11_22161 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Y11_22171 ENOG4105Y3E Modulates RecA activity (By similarity) Y11_22181 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Y11_22231 ENOG4108NEM leader-binding protein dmsD Y11_22241 ENOG4107KGK dmso reductase anchor subunit Y11_22251 ENOG4105QAX Iron-sulfur Y11_22261 ENOG4107QY8 reductase Y11_22271 ENOG4107GFK fumarate Y11_22291 ENOG4105C32 Amino acid ABC transporter (Permease) Y11_22301 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Y11_22311 ENOG4108IUZ ABC transporter Y11_22321 ENOG4108IV0 ABC, transporter Y11_22371 ENOG4105DKT Transcriptional regulator Y11_22381 ENOG4108XCU pts system Y11_22391 ENOG4105KPI PTS system sorbose subfamily IIB component Y11_22401 ENOG4105ETZ PTS System Y11_22411 ENOG4105F3R pts system mannose fructose sorbose family iid Y11_22421 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein Y11_22431 ENOG4105YVS arsR family transcriptional regulator Y11_22441 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Y11_22471 ENOG4105CA0 peroxidase Y11_22481 ENOG4105CIH Imidazole acetol-phosphate transaminase Y11_22491 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_22501 ENOG4105CHR reductase Y11_22531 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y11_22541 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y11_22561 ENOG4105DJY efflux transporter, rnd family, mfp subunit Y11_22571 ENOG4108JJA ABC, transporter Y11_22611 ENOG4105H8W Fimbrial protein Y11_22621 ENOG4105UGQ Fimbrial Y11_22641 ENOG4108FZ9 Chaperone Y11_22651 ENOG4106PG1 outer membrane usher protein Y11_22671 ENOG4108RQP Major type 1 subunit fimbrin Y11_22731 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Y11_22741 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y11_22751 ENOG4108K5P (LipO)protein Y11_22761 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Y11_22771 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Y11_22781 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) Y11_22791 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Y11_22811 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Y11_22821 ENOG4105N0Z inner membrane protein ygbE Y11_22831 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) Y11_22841 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) Y11_22851 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Y11_22861 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y11_22871 ENOG4108MXK alkaline phosphatase isozyme conversion Y11_22901 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Y11_22911 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Y11_22921 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Y11_22931 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Y11_22971 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Y11_23031 ENOG4108JQ1 Dehydrogenase Y11_23041 ENOG4105E66 phosphoriboisomerase A Y11_23051 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Y11_23061 ENOG4105MPN Membrane Y11_23071 ENOG4108ZUB Lysine exporter protein (Lyse ygga) Y11_23091 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_23111 ENOG4105D64 Mechanosensitive ion channel Y11_23131 ENOG4105D2N Aldolase Y11_23141 ENOG4105BZA Phosphoglycerate kinase Y11_23151 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Y11_23161 ENOG4105CV1 Transketolase (EC 2.2.1.1) Y11_23171 ENOG4108K0D peptidase, M48 Y11_23201 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) Y11_23221 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Y11_23251 ENOG41080HT Transcriptional regulator, arsr family Y11_23261 ENOG4105GPY SprT protein Y11_23271 ENOG4105RWS endonuclease I Y11_23281 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Y11_23291 ENOG4105D7Z glutathione synthase Y11_23301 ENOG4108UJU UPF0301 protein Y11_23311 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Y11_23321 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) Y11_23341 ENOG4105CZX twitching motility protein Y11_23351 ENOG4105DFA alanine racemase domain protein Y11_23361 ENOG4105II7 pyrroline-5-carboxylate reductase Y11_23371 ENOG4108VIA integral membrane protein Y11_23381 ENOG4105VZ9 UPF0235 protein Y11_23391 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Y11_23401 ENOG4105CSA Coproporphyrinogen iii oxidase Y11_23411 ENOG4105K33 Periplasmic Protein Y11_23421 ENOG4105CSV Glutaminase Y11_23431 ENOG41090ED Protein with unknown function (DUF469) Y11_23441 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Y11_23451 ENOG4105CEN a g-specific adenine glycosylase Y11_23461 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) Y11_23471 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division Y11_23491 ENOG4105CXN decarboxylase Y11_23601 ENOG4105D5Q Arginine ornithine antiporter Y11_23611 ENOG4105CXN decarboxylase Y11_23631 ENOG4108MI0 Resistance protein Y11_23641 ENOG4105J12 Multidrug resistance protein mdtN Y11_23681 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Y11_23691 ENOG4108IPW abc transporter atp-binding protein Y11_23701 ENOG4105CM4 permease protein Y11_23761 ENOG4105T38 integral membrane protein Y11_23771 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y11_23811 ENOG4105ETE Transcriptional regulator (LacI family Y11_23831 ENOG4105EAM Na Pi-cotransporter Y11_23861 ENOG4105CSH Transporter Y11_23871 ENOG4105BZS acriflavin resistance protein Y11_23921 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase Y11_23931 ENOG4107R3N Filamentation induced by cAMP protein fic Y11_23941 ENOG4105C8H hydrogenase maturation protein Hypf Y11_23951 ENOG4105C45 hydrogenase expression formation protein (HypE) Y11_23961 ENOG4105CQS hydrogenase expression formation protein HypD Y11_23971 ENOG41082MF Hydrogenase assembly chaperone hypC hupF Y11_23981 ENOG4107RSS Hydrogenase accessory protein HypB Y11_23991 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Y11_24001 ENOG4108WGS hydrogenase 2-specific chaperone Y11_24011 ENOG4108USZ hydrogenase Y11_24021 ENOG4105DPX Hydrogenase, large subunit Y11_24031 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit Y11_24041 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Y11_24051 ENOG4105E3S small subunit Y11_24061 ENOG4108XTF Outer Membrane Lipoprotein Y11_24081 ENOG4107RD7 Flagellar Motor Protein, MotA Y11_24131 ENOG4105MQ3 flagellar protein FliS Y11_24141 ENOG410804A Flagellar hook-associated 2 domain-containing protein Y11_24161 ENOG4105I03 Flagellin Y11_24191 ENOG4108M3R transcriptional activator CadC Y11_24261 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Y11_24271 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Y11_24291 ENOG4105CGA flagellar basal-body rod protein FlgG Y11_24301 ENOG4108KPB Flagellar basal-body rod protein FlgF Y11_24311 ENOG4105BZE flagellar hook protein, FlgE Y11_24321 ENOG4105W00 Flagellar hook capping protein Y11_24331 ENOG4108ZC9 flagellar basal-body rod protein flgc Y11_24341 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Y11_24381 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_24421 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Y11_24521 ENOG4108RAV Conserved protein Y11_24541 ENOG4108IJF Heavy metal efflux pump, CzcA Y11_24551 ENOG4105CF1 Alkylated DNA repair protein Y11_24711 ENOG4108ZZF transport protein (ExbD) Y11_24721 ENOG4105CWK Biopolymer transport protein, ExbB Y11_24731 ENOG4105C28 cystathionine Y11_24741 ENOG4108K81 inner membrane protein YghB Y11_24751 ENOG4105CF7 AraC family transcriptional regulator Y11_24761 ENOG4108I6A alcohol dehydrogenase Y11_24771 ENOG4105CV8 reductase Y11_24791 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) Y11_24801 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase Y11_24811 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y11_24821 ENOG4105NF4 modulator of drug activity Y11_24831 ENOG4105VRH Antibiotic biosynthesis monooxygenase Y11_24841 ENOG4105JQN Transcriptional regulator Y11_24851 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y11_24861 ENOG4105IPS esterase Y11_24871 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Y11_24881 ENOG4108SX3 cytoplasmic protein Y11_24891 ENOG41087AY ADP-Ribose pyrophosphatase Y11_24901 ENOG4105DFG type I secretion outer membrane protein Y11_24921 ENOG4105F1G UPF0441 protein Y11_24931 ENOG4106032 Glutathionylspermidine synthase Y11_24941 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Y11_24951 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Y11_24961 ENOG4105W0Z cytoplasmic protein Y11_24971 ENOG4105DVH amino acid Y11_24981 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) Y11_24991 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Y11_25001 ENOG4105I7R Adenylate cyclase Y11_25011 ENOG4106MWK domain protein Y11_25021 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Y11_25031 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Y11_25041 ENOG4107ZVW dihydroneopterin aldolase Y11_25051 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Y11_25061 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Y11_25071 ENOG4105VCC 30S ribosomal protein S21 Y11_25091 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Y11_25101 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y11_25431 ENOG4105ED4 portal protein Y11_25471 ENOG4105VZ1 Replication Protein Y11_25551 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y11_25561 ENOG4105EHZ conserved protein UCP016719 Y11_25581 ENOG4105D17 glycoside hydrolase, family 3 domain protein Y11_25601 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) Y11_25611 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Y11_25621 ENOG4105C5Y PTS System Y11_25631 ENOG4105CSV Glutaminase Y11_25641 ENOG4105E5D amino acid Y11_25651 ENOG4105CVK Glutamate decarboxylase Y11_25661 ENOG4105CVK Glutamate decarboxylase Y11_25681 ENOG4108YK4 Acid-resistance membrane protein Y11_25691 ENOG4108594 Permease of the drug metabolite transporter Y11_25701 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Y11_25721 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_25731 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Y11_25771 ENOG4108VKG metal-dependent hydrolase Y11_25781 ENOG4105EE0 oxidoreductase Y11_25791 ENOG4105DU1 integral membrane protein, terc Y11_25801 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Y11_25811 ENOG4105P66 Membrane Y11_25821 ENOG4105CTX dehydratase Y11_25831 ENOG4107QZW Altronate oxidoreductase Y11_25841 ENOG4105D2H Uronic isomerase Y11_25861 ENOG4105DPW Major facilitator superfamily MFS_1 Y11_25891 ENOG4106W5V Membrane Y11_25921 ENOG4105NE1 Conserved Protein Y11_25931 ENOG41090KG Inner membrane protein YqjE Y11_25941 ENOG4105YJD Y11_25951 ENOG4108VBZ doxx family Y11_25971 ENOG4105CHF Glutathione S-transferase Y11_25981 ENOG4105CWB LysR family transcriptional Regulator Y11_25991 ENOG4108CNN domain protein Y11_26001 ENOG4105DQ4 alcohol dehydrogenase Y11_26011 ENOG4105DQ4 alcohol dehydrogenase Y11_26021 ENOG4105DQ4 alcohol dehydrogenase Y11_26031 ENOG4107SET aldo keto reductase Y11_26041 ENOG4105EQ2 LysR family Transcriptional regulator Y11_26071 ENOG4108VEV chaperone Y11_26151 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Y11_26171 ENOG41082RQ UPF0102 protein Y11_26181 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Y11_26191 ENOG4105W4M Transport-associated protein Y11_26201 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_26211 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Y11_26221 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain Y11_26231 ENOG4105BZU Histidine kinase Y11_26241 ENOG4105N5T Radical SAM Protein Y11_26251 ENOG4105CBC glutamate synthase Y11_26261 ENOG4105BZ8 glutamate synthase Y11_26281 ENOG4105KB2 stringent starvation protein b Y11_26291 ENOG4107MKT Stringent starvation protein a Y11_26311 ENOG4108UJD 30S ribosomal protein S9 Y11_26321 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Y11_26331 ENOG4105D6Z AFG1 family ATPase Y11_26341 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III Y11_26351 ENOG4105C0H protease Y11_26361 ENOG4105C0H protease Y11_26371 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Y11_26381 ENOG4105VFK BolA family Y11_26391 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane Y11_26401 ENOG4105E3I toluene tolerance Y11_26411 ENOG4107PE3 Mammalian cell entry related domain protein Y11_26421 ENOG4105CY3 ABC transporter, permease Y11_26431 ENOG4105DHJ ABC, transporter Y11_26441 ENOG4105FEU K -dependent Na -Ca exchanger Y11_26451 ENOG4105C2X Arabinose 5-phosphate isomerase Y11_26461 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase Y11_26471 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) Y11_26481 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA Y11_26491 ENOG4108IUZ ABC transporter Y11_26501 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Y11_26511 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA Y11_26521 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Y11_26531 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Y11_26541 ENOG41080Z8 PHOSPHOCARRIER protein Y11_26561 ENOG4105CXT aspartate transcarbamylase Y11_26571 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) Y11_26581 ENOG4105KME endoribonuclease L-psp Y11_26641 ENOG4105CG3 alpha amylase, catalytic region Y11_26651 ENOG4105C5Y PTS System Y11_26661 ENOG4105D4X repressor Y11_26671 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Y11_26691 ENOG41084S7 Plasmid maintenance system antidote protein Y11_26701 ENOG4105EMD TRANSCRIPTIONal Y11_26711 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Y11_26751 ENOG41069H0 dihydroorotase EC 3.5.2.3 Y11_26821 ENOG4105NXH GreA GreB family elongation factor Y11_26831 ENOG4108XVM Cytochrome b(562) Y11_26841 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_26851 ENOG4105CMS peptidase U62, modulator of DNA gyrase Y11_26861 ENOG4105N42 UPF0307 protein Y11_26871 ENOG4105UNR (Barnase) inhibitor Y11_26901 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) Y11_26911 ENOG4105Y49 secretion protein, HlyD family Y11_26931 ENOG4105CR8 Transcriptional regulator Y11_27071 ENOG4105D1U peptidase U62 modulator of DNA gyrase Y11_27091 ENOG4105QD6 exported protein Y11_27101 ENOG4105C03 ribonuclease Y11_27121 ENOG4105VQ7 Rod shape-determining protein MreD Y11_27131 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) Y11_27141 ENOG4105DFF Rod shape-determining protein mreb Y11_27151 ENOG41062P1 Diguanylate cyclase phosphodiesterase Y11_27161 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Y11_27181 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Y11_27191 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Y11_27201 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Y11_27211 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Y11_27221 ENOG4105RG0 Membrane Y11_27231 ENOG4108IA2 Sodium pantothenate symporter Y11_27241 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Y11_27251 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Y11_27261 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) Y11_27271 ENOG4105BZU Histidine kinase Y11_27281 ENOG4108XTF Outer Membrane Lipoprotein Y11_27291 ENOG4105VEQ Cold shock protein Y11_27301 ENOG4105VEQ Cold shock protein Y11_27331 ENOG4107QPK )-transporter Y11_27341 ENOG4105D1S lipid A biosynthesis Y11_27351 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_27381 ENOG4105EZ7 amino acid ABC transporter Y11_27391 ENOG4105DRP amino acid AbC transporter Y11_27401 ENOG4105CDA abc transporter atp-binding protein Y11_27431 ENOG4105CMU LysR family (Transcriptional regulator Y11_27441 ENOG4105EEQ Na H antiporter Y11_27451 ENOG4105C7N Xanthine uracil vitamin C permease Y11_27481 ENOG4105CAF HipA N-terminal domain protein Y11_27491 ENOG4108UUM single-stranded DNA-binding protein Y11_27501 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Y11_27511 ENOG4105MSB protein, conserved in bacteria Y11_27521 ENOG4105CGF Aromatic amino acid aminotransferase Y11_27531 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Y11_27541 ENOG4105CDU Replicative dna helicase Y11_27551 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Y11_27571 ENOG4105P4Z Phage shock protein G Y11_27581 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Y11_27591 ENOG4105EXC Acyl-transferase Y11_27601 ENOG4105MYN Zinc uptake regulation protein Y11_27621 ENOG4105VDW Csbd family Y11_27631 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Y11_27641 ENOG41080IJ Diacylglycerol kinase Y11_27651 ENOG4105E55 glycerol-3-phosphate acyltransferase Y11_27661 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Y11_27671 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) Y11_27691 ENOG4107W52 maltose operon periplasmic protein Y11_27701 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) Y11_27721 ENOG4107FKK extracellular solute-binding protein family 1 Y11_27731 ENOG4105D56 permease protein Y11_27741 ENOG4105EG2 ABC transporter, permease Y11_27761 ENOG4107QP8 phosphohexose isomerase Y11_27771 ENOG4105CFH Aspartokinase Y11_27781 ENOG4105C09 Bile acid Y11_27811 ENOG4105C3R Methionine synthase Y11_27821 ENOG41069M3 Transcriptional regulator Y11_27831 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) Y11_27841 ENOG4108I9X Isocitrate lyase Y11_27851 ENOG4107QP3 malate synthase g Y11_27861 ENOG4105CVG Homoserine O-transsuccinylase Y11_27871 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_27891 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Y11_27911 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) Y11_27921 ENOG4108Y73 Membrane Y11_27931 ENOG4105EJ2 Transcriptional regulator Y11_27941 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) Y11_27951 ENOG4105C5Q Transcriptional regulator Y11_27961 ENOG4105EHV domain protein Y11_27971 ENOG4107QN2 dihydrolipoyl dehydrogenase Y11_27991 ENOG4107QZV Type I secretion membrane fusion protein Y11_28051 ENOG4105X58 receptor Y11_28061 ENOG4105CH7 arginosuccinase Y11_28081 ENOG4105CAS nag kinase Y11_28091 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Y11_28121 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Y11_28131 ENOG4105SYT Methylenetetrahydrofolate reductase Y11_28141 ENOG4105CFH Aspartokinase Y11_28151 ENOG4105C28 cystathionine Y11_28161 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) Y11_28171 ENOG4105VFB Binds the 23S rRNA (By similarity) Y11_28181 ENOG4105C25 Primosomal protein n' Y11_28191 ENOG4105ETE Transcriptional regulator (LacI family Y11_28201 ENOG41063M6 Cell Division Protein Y11_28211 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Y11_28221 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Y11_28231 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Y11_28241 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Y11_28251 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) Y11_28261 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Y11_28271 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Y11_28281 ENOG4105CBT Fructose-1,6-bisphosphatase Y11_28291 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_28301 ENOG4105E5M Multidrug resistance protein D Y11_28331 ENOG4105DP0 ferredoxin-NADP reductase Y11_28341 ENOG4108VTS Membrane Y11_28351 ENOG4105EBK exported protein Y11_28361 ENOG4105CP7 Triose-phosphate isomerase Y11_28381 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Y11_28401 ENOG41076HS cation diffusion facilitator family transporter Y11_28611 ENOG4105ED4 portal protein Y11_28651 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Y11_28661 ENOG4105VZ1 Replication Protein Y11_28701 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y11_28711 ENOG4105FMW periplasmic Y11_28721 ENOG4105E3W Two component transcriptional regulator (Winged helix family Y11_28731 ENOG4105E0F Histidine kinase Y11_28741 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Y11_28751 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Y11_28761 ENOG4105D7W serine acetyltransferase Y11_28771 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Y11_28781 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Y11_28791 ENOG4105VW4 glutaredoxin 3 Y11_28801 ENOG4107YZP Rhodanese domain protein Y11_28811 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Y11_28821 ENOG41063SB peptidase Y11_28831 ENOG4105PXI polysaccharide deacetylase Y11_28871 ENOG4105CPQ Dehydrogenase Y11_28881 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Y11_28891 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) Y11_28901 ENOG4105XA0 heptosyltransferase ii Y11_28911 ENOG4105D16 lipopolysaccharide heptosyltransferase i Y11_28921 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase Y11_28941 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Y11_28951 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Y11_28961 ENOG4105W0E 50S ribosomal protein L33 Y11_28971 ENOG4105KDC 50s ribosomal protein l28 Y11_28981 ENOG4105W5Q DNA repair protein (RadC Y11_28991 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Y11_29001 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Y11_29011 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Y11_29051 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Y11_29061 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Y11_29071 ENOG4105DSJ YicC domain protein Y11_29091 ENOG4105BZU Histidine kinase Y11_29101 ENOG4105E39 Enoyl-CoA hydratase Y11_29111 ENOG4105D9N nucleoside Y11_29131 ENOG4105EN6 Membrane Y11_29141 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) Y11_29161 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Y11_29171 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Y11_29181 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase Y11_29191 ENOG4105CB5 ATP-dependent DNA helicase recG Y11_29211 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_29221 ENOG4105D6U Sodium Glutamate Symporter Y11_29231 ENOG4105C2W permease Y11_29241 ENOG4105JV1 AsmA family Y11_29281 ENOG4105HVQ Regulatory factor of maltose metabolism Y11_29291 ENOG4105SUU thioesterase domain Y11_29301 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Y11_29311 ENOG4107S2Z UPF0761 membrane protein Y11_29321 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 Y11_29341 ENOG4105C5F glutamine synthetase Y11_29361 ENOG4105CUX Signal transduction histidine kinase Y11_29371 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y11_29381 ENOG4105D4P Coproporphyrinogen iii oxidase Y11_29391 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) Y11_29401 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Y11_29411 ENOG4105C2M dna polymerase I Y11_29421 ENOG4108Z33 Thiol disulfide Interchange Protein Y11_29431 ENOG4105E27 serine threonine protein kinase Y11_29441 ENOG4105PC1 Conserved Protein Y11_29461 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b Y11_29491 ENOG4107EJG GntR family transcriptional regulator Y11_29511 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y11_29521 ENOG4105ETE Transcriptional regulator (LacI family Y11_29531 ENOG4108RVA ribokinase Y11_29541 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Y11_29551 ENOG4105CNN ABC, transporter Y11_29571 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Y11_29591 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) Y11_29601 ENOG4105EV2 VWA domain protein interacting with AAA ATPase Y11_29621 ENOG4105CU9 asparagine synthetase A Y11_29631 ENOG4108VVK transcriptional Regulator, AsnC Y11_29641 ENOG4105QTB Flavodoxin Y11_29661 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Y11_29671 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Y11_29681 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation Y11_29691 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) Y11_29701 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Y11_29711 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Y11_29721 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Y11_29731 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Y11_29741 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Y11_29751 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Y11_29761 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Y11_29771 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Y11_29781 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Y11_29791 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Y11_29801 ENOG4105C8U phosphate abc transporter Y11_29811 ENOG4105E2Z phosphate ABC transporter (Permease Y11_29861 ENOG4106PMH Extracellular solute-binding protein family 3 Y11_29871 ENOG4105EAD ABC transporter Y11_29881 ENOG4105DRP amino acid AbC transporter Y11_29891 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 Y11_29901 ENOG4105C7N Xanthine uracil vitamin C permease Y11_29921 ENOG4108ZXC Two component transcriptional regulator, luxr family Y11_29931 ENOG4105BZU Histidine kinase Y11_29941 ENOG4108YYH Nadph-dependent fmn reductase Y11_29951 ENOG4105C8Q Methyl-accepting chemotaxis Y11_29961 ENOG4108UMI ABC transporter, permease Y11_29991 ENOG4105RKW reductase (By Y11_30001 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Y11_30011 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Y11_30021 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Y11_30031 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Y11_30051 ENOG4105VG0 50S ribosomal protein l34 Y11_30071 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Y11_30081 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Y11_30091 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Y11_30101 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Y11_30111 ENOG410667J hydrolase Y11_30151 ENOG4105D99 atp gtp-binding protein Y11_30161 ENOG4105R2A (LipO)protein Y11_30191 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_30211 ENOG4105D0C transport protein Y11_30221 ENOG4105JKW Valine--pyruvate aminotransferase Y11_30231 ENOG4107T9C Alpha amylase catalytic region Y11_30241 ENOG4105C5I Dehydrogenase Y11_30301 ENOG4105HNP -acetyltransferase Y11_30311 ENOG4108R3E Dna-3-methyladenine glycosylase i Y11_30321 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Y11_30331 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Y11_30341 ENOG4106JH6 (LipO)protein Y11_30351 ENOG4105CTS PTS system mannitol-specific Y11_30361 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase Y11_30371 ENOG4105E61 Mannitol repressor protein Y11_30391 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y11_30401 ENOG4108YYI Protein of unknown function (DUF2810) Y11_30421 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Y11_30431 ENOG4108RPX mosc domain containing protein Y11_30441 ENOG4105C8Q Methyl-accepting chemotaxis Y11_30461 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Y11_30481 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein Y11_30491 ENOG4108MG3 formate dehydrogenase Y11_30501 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) Y11_30511 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) Y11_30521 ENOG4105EM7 Selenocysteine-specific translation elongation factor Y11_30541 ENOG4105MEV Acyl-transferase Y11_30571 ENOG4108TTM chaperone Y11_30581 ENOG4105CMG Carbohydrate kinase Y11_30591 ENOG4105C93 Xylose Isomerase Y11_30601 ENOG4105C93 Xylose Isomerase Y11_30611 ENOG4105DFW ABC transporter Y11_30631 ENOG4107RNG ABC transporter Y11_30641 ENOG4105T16 Transcriptional regulator (AraC family) Y11_30651 ENOG4105T16 Transcriptional regulator (AraC family) Y11_30661 ENOG4105DFP Integrase Y11_30731 ENOG4105C85 amino acid Y11_30741 ENOG4105C84 Histidine ammonia-lyase Y11_30751 ENOG4105CGP Urocanate hydratase Y11_30771 ENOG4105CW0 outer membrane usher protein Y11_30801 ENOG4105EIP mannose-6-phosphate isomerase Y11_30811 ENOG4105CS2 ec 3.2.1.21 Y11_30851 ENOG4105CK1 PTS System Y11_30861 ENOG4105VZJ PTS System Y11_30871 ENOG4105CK1 PTS System Y11_30881 ENOG4105VCP PTS System Y11_30891 ENOG4105DKQ ROK family Y11_30901 ENOG41060NJ transcriptional regulator Y11_30941 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures Y11_30951 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles Y11_30961 ENOG4105D5G Transposase Y11_30981 ENOG4105CKT filamentous hemagglutinin Y11_30991 ENOG4105D5K Hemolysin activator protein Y11_31031 ENOG4105CXY transporter Y11_31041 ENOG4105BZU Histidine kinase Y11_31051 ENOG4108KX4 response regulator Y11_31061 ENOG4105DIJ Phosphoethanolamine transferase Y11_31071 ENOG4108ZHJ Organic hydroperoxide resistance protein Y11_31081 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_31101 ENOG4105DEF Extracellular solute-binding protein, family 5 Y11_31111 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Y11_31121 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Y11_31131 ENOG4105C3U ABC transporter Y11_31141 ENOG4108JQ7 (ABC) transporter Y11_31151 ENOG4105D1V cellulose synthase operon protein YhjU Y11_31161 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT Y11_31171 ENOG4105U74 cellulose biosynthesis protein BcsE Y11_31191 ENOG4105UTS cellulose synthase operon protein YhjQ Y11_31201 ENOG4107QZ7 Cellulose synthase catalytic subunit Y11_31211 ENOG4107EEX Cellulose synthase regulator protein Y11_31221 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) Y11_31231 ENOG4105EJG cellulose synthase Y11_31241 ENOG4105EJG cellulose synthase Y11_31251 ENOG4105BZU Histidine kinase Y11_31261 ENOG4108PU9 oligogalacturonate-specific porin Y11_31291 ENOG4105CK2 sodium dicarboxylate symporter Y11_31301 ENOG4105CS0 peptidase Y11_31311 ENOG4107SS6 2-dehydro-3-deoxygluconokinase Y11_31321 ENOG4105VSH 4-oxalocrotonate tautomerase Y11_31341 ENOG4105CMB EAL domain-containing protein Y11_31351 ENOG41066T0 asmA family Y11_31361 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) Y11_31371 ENOG4107H3J ribonuclease Y11_31391 ENOG4105DC8 reductase Y11_31401 ENOG4105D6S protein involved in catabolism of external DNA Y11_31411 ENOG4105DGW oligopeptidase A Y11_31421 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) Y11_31451 ENOG4108M6U Universal stress protein A Y11_31461 ENOG4108V6B universal stress protein B Y11_31471 ENOG4105CJ3 phosphate transporter Y11_31481 ENOG4105CBX hi0933 family Y11_31491 ENOG4105CK2 sodium dicarboxylate symporter Y11_31531 ENOG4105DJI Methylaspartate mutase, E subunit Y11_31551 ENOG4107WFU Glutamate mutase subunit sigma Y11_31561 ENOG4105JZC GHMP kinase Y11_31571 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y11_31591 ENOG41090KR LysR family transcriptional Regulator Y11_31601 ENOG4107GFK fumarate Y11_31611 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Y11_31621 ENOG4108HCJ Hydrolase Y11_31641 ENOG4105CR8 Transcriptional regulator Y11_31651 ENOG4105EQ0 Major Facilitator superfamily Y11_31661 ENOG4105C26 Dehydrogenase Y11_31671 ENOG4105DH8 myo-inositol catabolism Y11_31691 ENOG4105D7K pfkb domain protein Y11_31711 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Y11_31721 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Y11_31731 ENOG4105WCN acetyltransferase Y11_31741 ENOG4105C2I pirin domain protein Y11_31751 ENOG4105DIQ Transcriptional regulator Y11_31761 ENOG4105C6Z Gluconate Y11_31771 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Y11_31781 ENOG41076UM multiple antibiotic resistance (MarC)-related protein Y11_31791 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Y11_31801 ENOG4105C7K acetolactate synthase Y11_31831 ENOG4108HRK Histidine kinase Y11_31841 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Y11_31851 ENOG4108IUM Glycogen debranching enzyme Y11_31871 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Y11_31881 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Y11_31891 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Y11_31911 ENOG4105E98 transcriptional regulator DeoR family Y11_31921 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) Y11_31951 ENOG41061ZR Transcriptional regulator Y11_31961 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Y11_31971 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) Y11_31981 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_31991 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) Y11_32001 ENOG4105MJ2 Competence protein Y11_32021 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Y11_32031 ENOG4105RID UPF0379 protein yhcN Y11_32041 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) Y11_32051 ENOG4105CE1 Ferrous iron transport protein b Y11_32071 ENOG4105XFK Ferrous iron transport protein A Y11_32081 ENOG4105BZM domain protein Y11_32141 ENOG4108RRZ Transcription elongation factor GreB Y11_32151 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Y11_32161 ENOG4105E0F Histidine kinase Y11_32191 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Y11_32211 ENOG4105VEJ Heat shock protein Y11_32221 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 Y11_32231 ENOG4105DQY intracellular growth attenuator Y11_32241 ENOG4105DQY intracellular growth attenuator Y11_32261 ENOG4107RK2 ADP-ribose diphosphatase NudE Y11_32271 ENOG4108JQC penicillin-binding protein 1A Y11_32321 ENOG4105E4G Type IV pilus Y11_32331 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Y11_32371 ENOG4105DJV ribulose-phosphate 3-epimerase Y11_32391 ENOG4105C31 Tryptophanyl-tRNA synthetase Y11_32401 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Y11_32411 ENOG4107V9H nitrite transporter Y11_32421 ENOG4105WZK nitrite reductase NADPH small subunit Y11_32431 ENOG4107QZF nitrite reductase NADPH large subunit Y11_32451 ENOG4105DZC cytosine deaminase Y11_32461 ENOG4106DTQ Protein TsgA homolog Y11_32471 ENOG41060NJ transcriptional regulator Y11_32481 ENOG4105F8D glycoside hydrolase family 4 Y11_32501 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Y11_32511 ENOG4105D7A ATP-binding protein Y11_32531 ENOG4105C8Y Acetylornithine aminotransferase Y11_32541 ENOG4105C8Y Acetylornithine aminotransferase Y11_32551 ENOG410613R integral membrane protein, YccS YhfK family Y11_32571 ENOG4108UKZ OsmC family Y11_32581 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) Y11_32591 ENOG4105YP7 UPF0270 protein Y11_32601 ENOG4105DNZ Alpha Beta Hydrolase Y11_32621 ENOG4105JAB phenazine biosynthesis protein, phzf family Y11_32641 ENOG4106FTQ Taurine ABC transporter, periplasmic Y11_32661 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Y11_32671 ENOG4105E2B Taurine dioxygenase Y11_32691 ENOG4105K64 Glycosyl transferase, family 2 Y11_32701 ENOG4105C5H ABC transporter Y11_32711 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein Y11_32731 ENOG4105VKU nucleicacid-binding protein Y11_32741 ENOG4108YZY peptidylprolyl cis-trans isomerase Y11_32761 ENOG4108V1T peptidylprolyl cis-trans isomerase Y11_32771 ENOG4105WWK YheO domain protein Y11_32781 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) Y11_32791 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) Y11_32801 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) Y11_32821 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Y11_32841 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Y11_32881 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Y11_32891 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Y11_32901 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Y11_32911 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Y11_32921 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Y11_32931 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Y11_32941 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Y11_32951 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Y11_32961 ENOG41083MP 50s ribosomal protein l29 Y11_32981 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Y11_32991 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Y11_33001 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Y11_33021 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Y11_33031 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Y11_33041 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Y11_33051 ENOG4105VPB 50S ribosomal protein L30 Y11_33061 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Y11_33071 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Y11_33081 ENOG41067V7 50S ribosomal protein L36 Y11_33091 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Y11_33101 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Y11_33111 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Y11_33121 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Y11_33131 ENOG4108ZT0 50S ribosomal protein l17 Y11_33141 ENOG4105VTS DnaJ-like, subfamily C Y11_33151 ENOG4105W1Y Transcriptional regulator Y11_33161 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system Y11_33191 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Y11_33201 ENOG4105C1A potassium transporter peripheral membrane Y11_33211 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Y11_33221 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Y11_33231 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Y11_33241 ENOG4105C79 DNA protecting protein DprA Y11_33261 ENOG4108WI1 Dna topoisomerase Y11_33271 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Y11_33281 ENOG4105E2X shikimate dehydrogenase Y11_33291 ENOG4108Z0R Transferase Y11_33331 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator Y11_33341 ENOG4105C2J ABC transporter Y11_33351 ENOG4107R9N ABC transporter Y11_33361 ENOG41062B0 ABC transporter, permease Y11_33371 ENOG4105CVI Transcriptional regulator Y11_33381 ENOG4108WFC UPF0438 protein yifE Y11_33391 ENOG4105C0P Mg chelatase subunit ChlI Y11_33421 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit Y11_33431 ENOG4105CM2 brancheD-chain amino acid aminotransferase Y11_33451 ENOG4105C01 Dihydroxy-acid dehydratase Y11_33461 ENOG4105C7B Threonine dehydratase Y11_33491 ENOG4105EMY transcriptional regulator Y11_33501 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Y11_33511 ENOG4108MA7 Inherit from COG: YD repeat protein Y11_33531 ENOG41060S4 immunity protein Y11_33551 ENOG4108VEV chaperone Y11_33571 ENOG4105CW0 outer membrane usher protein Y11_33581 ENOG4105GQR Chaperone Y11_33601 ENOG4105KQ5 peptidylprolyl cis-trans isomerase Y11_33611 ENOG4105C4R Atp-dependent dna helicase Y11_33631 ENOG4105C9X ppx gppa phosphatase Y11_33651 ENOG4105K63 Thioredoxin Y11_33671 ENOG4105ESV Glycosyl transferase, family 4 Y11_33681 ENOG4105SFE lipopolysaccharide biosynthesis protein Y11_33691 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Y11_33701 ENOG4108IJ1 Dehydrogenase Y11_33711 ENOG4105C1B dTDP-glucose 4-6-dehydratase Y11_33721 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Y11_33731 ENOG4108WJ1 acetyltransferase Y11_33741 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Y11_33751 ENOG4105EGZ biosynthesis protein Y11_33761 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) Y11_33791 ENOG4105C85 amino acid Y11_33801 ENOG4105C85 amino acid Y11_33821 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_33831 ENOG410601J HemY protein Y11_33841 ENOG4105ECF c-methyltransferase Y11_33851 ENOG41076E6 Uroporphyrinogen-III Synthase Y11_33861 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Y11_33891 ENOG4105XQ6 frataxin-like protein Y11_33901 ENOG4105S7Z (LipO)protein Y11_33911 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Y11_33921 ENOG4105CT0 Protein of unknown function, DUF484 Y11_33931 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y11_33941 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant Y11_33951 ENOG4105C4R Atp-dependent dna helicase Y11_33971 ENOG4105EQN UPF0261 protein Y11_33991 ENOG4107QUT magnesium and cobalt transport protein CorA Y11_34001 ENOG4105FR1 rard protein Y11_34011 ENOG4108VUY thioesterase Superfamily protein Y11_34021 ENOG4105HDD phospholipase Y11_34031 ENOG4105C9U ATP-dependent DNA helicase RecQ Y11_34041 ENOG4105CCF Lysine exporter protein (Lyse ygga) Y11_34061 ENOG4108EUD Lysophospholipase Y11_34071 ENOG4105DQF Hydrolase Y11_34081 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_34091 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Y11_34101 ENOG4105CXY transporter Y11_34121 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A Y11_34131 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B Y11_34141 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Y11_34151 ENOG4108W1V Lipoprotein Y11_34161 ENOG4105EX9 Membrane Y11_34171 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) Y11_34181 ENOG4105C59 p-type ATPase Y11_34191 ENOG4107FS9 Membrane Y11_34221 ENOG4105MG3 Membrane Y11_34231 ENOG4106H78 methyltransferase Y11_34251 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Y11_34261 ENOG4105CAK Cell division ATP-binding protein ftsE Y11_34271 ENOG4105CRP Part of the ABC transporter FtsEX involved in Y11_34311 ENOG4105U59 -acetyltransferase Y11_34321 ENOG4105CP9 extracellular ligand-binding receptor Y11_34331 ENOG4105C32 Amino acid ABC transporter (Permease) Y11_34341 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Y11_34351 ENOG4105C0Z ABC transporter Y11_34361 ENOG4108IV0 ABC, transporter Y11_34441 ENOG4105BZ7 extracellular solute-binding protein family 1 Y11_34451 ENOG4105BZ7 extracellular solute-binding protein family 1 Y11_34461 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component Y11_34471 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Y11_34481 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Y11_34491 ENOG4107T6V glycerophosphoryl diester phosphodiesterase Y11_34501 ENOG4105RK9 auxin efflux carrier Y11_34511 ENOG4105DZ2 Transcriptional regulator Y11_34521 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Y11_34531 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Y11_34541 ENOG4108I5U Uridine phosphorylase Y11_34611 ENOG4108KF1 Membrane Y11_34621 ENOG4105CGY Dna recombination protein Y11_34631 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Y11_34641 ENOG4105JC1 sterol-binding domain protein Y11_34651 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Y11_34661 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Y11_34671 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Y11_34681 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Y11_34701 ENOG4105D52 delta-aminolevulinic acid dehydratase Y11_34711 ENOG4105MDZ Transcriptional activator rfaH Y11_34721 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Y11_34731 ENOG4107QK7 reductase Y11_34741 ENOG4105CHU acetyl-coa acetyltransferase Y11_34751 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Y11_34761 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) Y11_34771 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Y11_34781 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) Y11_34791 ENOG4108RR8 protoporphyrinogen oxidase Y11_34811 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_34831 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Y11_34841 ENOG4105CS9 pantothenic acid kinase Y11_34871 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Y11_34881 ENOG4105PM1 preprotein translocase subunit SecE Y11_34891 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Y11_34901 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Y11_34911 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Y11_34921 ENOG4108VZM 50s ribosomal protein L10 Y11_34931 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Y11_34941 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Y11_34951 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Y11_34961 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_34971 ENOG4105D41 biosynthesis protein thiH Y11_34981 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Y11_34991 ENOG4105WHD thiamine biosynthesis protein ThiS Y11_35001 ENOG4105D06 uba thif-type nad fad binding protein Y11_35021 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Y11_35031 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor Y11_35041 ENOG4105E09 nadh pyrophosphatase Y11_35051 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Y11_35061 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) Y11_35071 ENOG4105R2J Conserved Protein Y11_35091 ENOG4108T8B Protein of unknown function (DUF1481) Y11_35101 ENOG4105C12 Phosphoribosylglycinamide synthetase Y11_35111 ENOG4105DC1 bifunctional purine biosynthesis protein purh Y11_35131 ENOG4107QN1 sodium solute Y11_35141 ENOG41062QD Membrane Y11_35151 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Y11_35161 ENOG4105CK2 sodium dicarboxylate symporter Y11_35171 ENOG4105WH1 Two component transcriptional regulator luxr family Y11_35181 ENOG4105BZU Histidine kinase Y11_35261 ENOG4108SZ7 secretion system effector Y11_35381 ENOG4106H1D secretion system apparatus protein Y11_35401 ENOG4108JIR Flagellum-specific ATP synthase Y11_35431 ENOG41063Q7 Type III secretion system protein Y11_35451 ENOG4108HHI Type III secretion system protein Y11_35461 ENOG41083GP type iii secretion Y11_35471 ENOG4108TN6 type iii secretion Y11_35481 ENOG4108TN6 type iii secretion Y11_35491 ENOG4108IUF type iii secretion Y11_35501 ENOG41066VF YeeE YedE family protein Y11_35511 ENOG41066VF YeeE YedE family protein Y11_35521 ENOG4105KSU Redox protein Y11_35571 ENOG4108S3W Anti-feci sigma factor, fecr Y11_35581 ENOG4105PE1 Receptor Y11_35591 ENOG4105CQ0 ABC transporter Y11_35601 ENOG4107RAN Peptidase, M16 Y11_35611 ENOG4105VTW prevent-host-death family Y11_35621 ENOG4105KRQ Addiction module toxin, Txe YoeB family Y11_35631 ENOG4105EGS Mechanosensitive ion channel Y11_35641 ENOG4105E0K tonB-dependent siderophore receptor Y11_35661 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Y11_35671 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Y11_35681 ENOG4105EHG Permease protein Y11_35691 ENOG4107R4I Periplasmic binding protein Y11_35701 ENOG4106QJH hemin transport protein Y11_35711 ENOG4107ENK receptor Y11_35721 ENOG4107F3C Hemin uptake protein Y11_35741 ENOG41090JE Utilization Protein Y11_35751 ENOG4105D4P Coproporphyrinogen iii oxidase Y11_35761 ENOG4105C7B Threonine dehydratase Y11_35771 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) Y11_35781 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Y11_35791 ENOG4105C6N Formate acetyltransferase Y11_35801 ENOG4108SIC Transcriptional regulator Y11_35811 ENOG4105BZW Glycerate kinase Y11_35821 ENOG4105BZW Glycerate kinase Y11_35831 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Y11_35851 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Y11_35881 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Y11_35891 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Y11_35901 ENOG4108ZVF (LipO)protein Y11_35911 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Y11_35921 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Y11_35941 ENOG4105KPY Small multidrug resistance protein Y11_35961 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) Y11_35971 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) Y11_36001 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) Y11_36011 ENOG4105EGS Mechanosensitive ion channel Y11_36021 ENOG4105DJ4 phosphatidylserine decarboxylase Y11_36031 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Y11_36041 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Y11_36051 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Y11_36061 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Y11_36071 ENOG4105K8N protein family UPF0079, ATPase Y11_36081 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Y11_36091 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Y11_36101 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Y11_36111 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Y11_36121 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Y11_36131 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Y11_36141 ENOG4107QJR hflk protein Y11_36151 ENOG4105EPW hflc protein Y11_36171 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Y11_36181 ENOG4105KPV Transcriptional regulator Y11_36191 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Y11_36201 ENOG4105C2N RNA methyltransferase TrmH family group 3 Y11_36221 ENOG4105CSU acyl-Coa dehydrogenase Y11_36231 ENOG4105CSU acyl-Coa dehydrogenase Y11_36241 ENOG4105WSB biofilm stress and motility protein A Y11_36251 ENOG4108MXZ Esterase Y11_36271 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Y11_36281 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) Y11_36291 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Y11_36301 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Y11_36321 ENOG4105FHY Opacity-associated protein A Y11_36331 ENOG4108V1T peptidylprolyl cis-trans isomerase Y11_36351 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic Y11_36361 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Y11_36371 ENOG4108UUE Transcriptional regulator Y11_36381 ENOG41061GZ Protein of unknown function (DUF1107) Y11_36391 ENOG4105C37 (CBS) domain Y11_36401 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Y11_36431 ENOG4105MA0 exported protein Y11_36441 ENOG4108ZHD aig2 family Y11_36451 ENOG4105F0N pyrophosphate phospho-hydrolase Y11_36471 ENOG4105C8Q Methyl-accepting chemotaxis Y11_36481 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Y11_36491 ENOG4105DFU Cell wall formation (By similarity) Y11_36511 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) Y11_36521 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Y11_36541 ENOG4105EAH synthase Y11_36551 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Y11_36561 ENOG4105K46 50S ribosomal protein l27 Y11_36571 ENOG4105QYV Membrane Y11_36581 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Y11_36611 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase Y11_36621 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Y11_36631 ENOG4105HBR Rna-binding protein Y11_36641 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Y11_36651 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Y11_36661 ENOG4105EEI dihydropteroate synthase Y11_36671 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Y11_36691 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Y11_36701 ENOG4105CHV Transcription elongation factor NusA Y11_36711 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Y11_36721 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Y11_36731 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Y11_36741 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Y11_36751 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Y11_36771 ENOG4105C1J atp-dependent rna helicase Y11_36791 ENOG4105DEN Luciferase family Y11_36801 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Y11_36811 ENOG4105C44 Serine transporter Y11_36821 ENOG4105CEM UPF0597 protein Y11_36831 ENOG4106RZ4 Peptidase U32 Y11_36841 ENOG4105CFP Peptidase U32 Y11_36851 ENOG4105XPQ lipid carrier protein Y11_36861 ENOG4108YYD acetyltransferase Y11_36871 ENOG41082IR Excinuclease ABC C subunit domain protein Y11_36881 ENOG4105D5Q Arginine ornithine antiporter Y11_36891 ENOG4105CXN decarboxylase Y11_36911 ENOG4105EY3 heparinase II III family protein Y11_36941 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component Y11_36951 ENOG4105DRS transport system, permease Y11_36981 ENOG4108ZPB UPF0306 protein Y11_37011 ENOG4105K4T epimerase Y11_37021 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein Y11_37031 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) Y11_37041 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) Y11_37051 ENOG4105FD8 phosphonate metabolism protein PhnM Y11_37061 ENOG4105HRV phosphonate c-p lyase system protein phnl Y11_37071 ENOG4105ENV phosphonate C-P lyase system protein PhnK Y11_37081 ENOG4105FT8 Phosphonate metabolism Y11_37091 ENOG4105EKV Phosphonate metabolism protein Y11_37101 ENOG4105EKV Phosphonate metabolism protein Y11_37111 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH Y11_37121 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG Y11_37131 ENOG4107RJJ Transcriptional regulator Y11_37161 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) Y11_37171 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Y11_37201 ENOG4108JQ7 (ABC) transporter Y11_37211 ENOG4105C3U ABC transporter Y11_37221 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Y11_37231 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Y11_37261 ENOG4105XEP YhcH YjgK YiaL family protein Y11_37281 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) Y11_37311 ENOG4108MJ3 acetyltransferase Y11_37331 ENOG4105MYG DNA polymerase iii, chi subunit Y11_37341 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Y11_37351 ENOG4108M8S permease YjgP YjgQ family protein Y11_37361 ENOG4108K5H permease YjgP YjgQ family protein Y11_37461 ENOG4105VEV -acetyltransferase Y11_37551 ENOG4105RI1 glycoprotein receptor Y11_37571 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound Y11_37581 ENOG41061GT Aldolase Y11_37591 ENOG4105D4B ABC, transporter Y11_37601 ENOG4105F5R ABC transporter Y11_37611 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane Y11_37621 ENOG4105C2J ABC transporter Y11_37631 ENOG4105DKT Transcriptional regulator Y11_37641 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) Y11_37651 ENOG4105DKP glycosyl transferase, family 9 Y11_37671 ENOG4105D5Q Arginine ornithine antiporter Y11_37681 ENOG4105CEU Arginine dihydrolase Y11_37691 ENOG410624X efflux transporter, rnd family, mfp subunit Y11_37701 ENOG4105BZS acriflavin resistance protein Y11_37721 ENOG4105CMT Dihydroxyacetone kinase Y11_37731 ENOG4108UTZ Dihydroxyacetone kinase Y11_37741 ENOG4105VDH Dihydroxyacetone kinase Y11_37821 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Y11_37831 ENOG4105WBN Transcriptional regulator (LacI family Y11_37841 ENOG4108HKT sucrose-6-phosphate hydrolase Y11_37871 ENOG4105D7K pfkb domain protein Y11_37891 ENOG4105GAV receptor Y11_37901 ENOG4105BZU Histidine kinase Y11_37931 ENOG4105YBH Protein of unknown function (DUF1435) Y11_37941 ENOG4105CBN LysR family transcriptional regulator Y11_37951 ENOG4105CPC Aldo Keto reductase Y11_37961 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Y11_37971 ENOG4108WPU DNA polymerase III subunit psi Y11_37981 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Y11_37991 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Y11_38001 ENOG4105K3G Periplasmic Protein Y11_38021 ENOG4108NRW Phospholipase, patatin family Y11_38031 ENOG4105EYA deoxyribonuclease Y11_38041 ENOG4105D9N nucleoside Y11_38051 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Y11_38061 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Y11_38071 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Y11_38081 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Y11_38091 ENOG41062Z9 Membrane Y11_38101 ENOG4105EAC phosphoserine phosphatase Y11_38111 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Y11_38131 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase Y11_38141 ENOG4105CIS alcohol dehydrogenase Y11_38171 ENOG4105C5H ABC transporter Y11_38181 ENOG41090EK ompa motb domain protein Y11_38191 ENOG4108KHX Diguanylate cyclase Y11_38221 ENOG4107SC1 transglycosylase Y11_38231 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) Y11_38241 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Y11_38251 ENOG4105CVJ phosphoglycerate mutase Y11_38261 ENOG4105UEI Transcriptional Regulator AraC Family Y11_38271 ENOG4108RH0 Crea protein Y11_38281 ENOG41065U4 response regulator Y11_38291 ENOG410759A Y11_38321 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Y11_38341 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_38351 ENOG4105D1Q UPF0246 protein Y11_38361 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Y11_38371 ENOG4108RIR Molybdenum cofactor biosynthesis protein Y11_38391 ENOG4107F1U Beta/Gamma crystallin Y11_38401 ENOG4106HK8 GPR1 FUN34 yaaH family protein Y11_38411 ENOG4105CFG Acts as a chaperone (By similarity) Y11_38421 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Y11_38431 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Y11_38441 ENOG41063Z6 transcriptional regulator, lysR family Y11_38451 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Y11_38461 ENOG4105DTN riboflavin biosynthesis protein ribF Y11_38471 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Y11_38481 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Y11_38491 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase Y11_38501 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Y11_38511 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Y11_38521 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Y11_38531 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Y11_38541 ENOG4105N14 lysine exporter protein LysE YggA Y11_38551 ENOG4105DWK Membrane Y11_38561 ENOG4107XM3 UPF0442 protein Y11_38571 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Y11_38581 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Y11_38591 ENOG4105NWN ApaG protein Y11_38601 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Y11_38621 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Y11_38631 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) Y11_38641 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) Y11_38651 ENOG4105D3G Pseudouridine synthase Y11_38661 ENOG4105TNG K13735 adhesin invasin Y11_38671 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Y11_38681 ENOG4105CQ2 DNA polymerase Y11_38691 ENOG4108KF1 Membrane Y11_38711 ENOG4106SMU thiamine transporter membrane protein Y11_38721 ENOG4105DP9 ABC transporter Y11_38751 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) Y11_38761 ENOG4105F1A Pyruvate formate-lyase Y11_38771 ENOG4105C6N Formate acetyltransferase Y11_38791 ENOG4105S8Q sugar efflux transporter Y11_38801 ENOG4105CIC tryptophan-specific transport protein Y11_38811 ENOG4105C0F tryptophanase EC 4.1.99.1 Y11_38821 ENOG4105C0F tryptophanase EC 4.1.99.1 Y11_38841 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Y11_38851 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Y11_38861 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Y11_38881 ENOG41064T2 transcriptional regulator, lysR family Y11_38891 ENOG4108IQE Amp-dependent synthetase and ligase Y11_38911 ENOG4105C7K acetolactate synthase Y11_38921 ENOG4108ZP8 Acetolactate synthase small subunit Y11_38931 ENOG4107B7Y DNA-binding transcriptional regulator FruR Y11_38961 ENOG4108V6E Cell division protein mraZ Y11_38971 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Y11_38981 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) Y11_38991 ENOG4105CJN penicillin-binding protein Y11_39001 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Y11_39011 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) Y11_39021 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Y11_39041 ENOG4105CNI cell division protein FtsW Y11_39051 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Y11_39061 ENOG4105DFU Cell wall formation (By similarity) Y11_39081 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) Y11_39091 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Y11_39101 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Y11_39131 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) Y11_39141 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Y11_39151 ENOG4105M6F mutator MutT protein Y11_39161 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) Y11_39181 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Y11_39191 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Y11_39201 ENOG4105D7Q type ii secretion system Y11_39211 ENOG4107QHF type ii secretion system protein e Y11_39221 ENOG4108ZUW Major pilin subunit Y11_39231 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Y11_39251 ENOG4106A72 regulatory protein AmpE Y11_39261 ENOG4105C85 amino acid Y11_39271 ENOG4105C85 amino acid Y11_39291 ENOG41073TP transcriptional regulator Y11_39301 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Y11_39311 ENOG4107QSN dihydrolipoamide acetyltransferase Y11_39321 ENOG4107QN2 dihydrolipoyl dehydrogenase Y11_39341 ENOG4105ECQ AraC Family Transcriptional Regulator Y11_39351 ENOG4107RNH Outer membrane receptor FepA Y11_39361 ENOG4107QIJ Aconitate hydratase 2 Y11_39371 ENOG4108ZIG UPF0231 protein Y11_39381 ENOG4105RPH Inner membrane protein YddG Y11_39411 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Y11_39421 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Y11_39431 ENOG4108ZRK uncharacterized protein yacC Y11_39441 ENOG4105E3B Multicopper oxidase Y11_39451 ENOG4108UGV hypoxanthine phosphoribosyltransferase Y11_39461 ENOG41077A9 carbonic anhydrase Y11_39471 ENOG4105DA5 (ABC) transporter Y11_39481 ENOG4105E3A (ABC) transporter Y11_39501 ENOG4107BJW polysaccharide deacetylase Y11_39511 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Y11_39521 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Y11_39531 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Y11_39541 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Y11_39551 ENOG4105DJ0 Poly(A) Polymerase Y11_39571 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Y11_39581 ENOG4105PW4 Sugar fermentation stimulation protein homolog Y11_39591 ENOG4107XID 2'-5' rna ligase Y11_39601 ENOG4105CQ7 ATP-dependent helicase Y11_39611 ENOG4105BZ4 penicillin-binding protein Y11_39621 ENOG4105E0A ABC, transporter Y11_39631 ENOG4105J76 Periplasmic binding protein Y11_39641 ENOG4105S6R Iron-hydroxamate transporter permease subunit Y11_39651 ENOG4105DQQ Major facilitator superfamily MFS_1 Y11_39661 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Y11_39691 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Y11_39711 ENOG4105EN6 Membrane Y11_39731 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Y11_39741 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Y11_39751 ENOG4105C0H protease Y11_39761 ENOG4105BZU Histidine kinase Y11_39771 ENOG4105BZU Histidine kinase Y11_39781 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Y11_39791 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Y11_39801 ENOG4105DXN mazG family Y11_39811 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Y11_39821 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Y11_39831 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Y11_39841 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) Y11_39851 ENOG4105E07 UPF0149 protein Y11_39861 ENOG4107RAQ aminopeptidase Y11_39871 ENOG4105D0A hydroxylase Y11_39881 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family Y11_39901 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Y11_39911 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Y11_39921 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Y11_39941 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Y11_39961 ENOG4108UT2 hemolysin iii Y11_39971 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_39991 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Y11_40001 ENOG4105Y75 tpr repeat protein Y11_40021 ENOG4105E3W Two component transcriptional regulator (Winged helix family Y11_40031 ENOG4105EB3 Histidine kinase Y11_40041 ENOG4105EB3 Histidine kinase Y11_40051 ENOG4105CT7 inner membrane cred family protein Y11_40061 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) Y11_40071 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Y11_40081 ENOG4105T95 Thiol disulfide interChange protein Y11_40091 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Y11_40101 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Y11_40111 ENOG4105CRK lysyL-tRNA synthetase Y11_40151 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation Y11_40161 ENOG4105WJ3 XRE family Transcriptional regulator Y11_40171 ENOG4105D5G Transposase Y11_40211 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein Y11_40221 ENOG4105BZU Histidine kinase Y11_40231 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_40251 ENOG4105DVC DnaJ domain protein Y11_40271 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr Y11_40281 ENOG4105KVH Transcriptional regulator Y11_40291 ENOG4107B2H carbonic anhydrase Y11_40341 ENOG4107QHF type ii secretion system protein e Y11_40351 ENOG4105D7Q type ii secretion system Y11_40361 ENOG4105D7Q type ii secretion system Y11_40371 ENOG4108VAU general secretion pathway protein G Y11_40451 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) Y11_40501 ENOG4105C8Q Methyl-accepting chemotaxis Y11_40531 ENOG4105EJC lysr family transcriptional regulator Y11_40541 ENOG4105F27 Major Facilitator Y11_40551 ENOG4105RQF LysR family Transcriptional regulator Y11_40561 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Y11_40571 ENOG41060NJ transcriptional regulator Y11_40591 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_40601 ENOG4105CEY Amp-dependent synthetase and ligase Y11_40611 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) Y11_40621 ENOG4105CPC Aldo Keto reductase Y11_40631 ENOG4105EE5 Membrane protein terC Y11_40641 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) Y11_40661 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Y11_40671 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase Y11_40681 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Y11_40691 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Y11_40731 ENOG4105RVB Prepilin peptidase dependent protein c Y11_40741 ENOG4105DSY exodeoxyribonuclease V, gamma Y11_40751 ENOG4107QXK peptidase Y11_40761 ENOG4107QKA exodeoxyribonuclease V beta Y11_40771 ENOG4107QYX exodeoxyribonuclease v alpha Y11_40781 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_40791 ENOG4107QZM n-acetylglutamate synthase Y11_40801 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Y11_40811 ENOG4105CA3 membrane-bound lytic murein transglycosylase Y11_40821 ENOG4105CUZ uba thif-type nad fad binding protein Y11_40831 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Y11_40841 ENOG4105C9B Cysteine desulfurase Y11_40851 ENOG4105M5B (LipO)protein Y11_40861 ENOG4105ETT transcriptional Regulator, LysR family Y11_40871 ENOG4105M08 Membrane Y11_40881 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) Y11_40891 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_40901 ENOG4105D5G Transposase Y11_40911 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease Y11_40921 ENOG4105EWT decarboxylase family Y11_40931 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Y11_40941 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) Y11_40951 ENOG4105WP7 tRNA pseudouridine synthase C Y11_40961 ENOG4105DR9 pseudouridine synthase Y11_40971 ENOG4105QDK Flavodoxin Y11_40981 ENOG4108T8E UPF0325 protein Y11_40991 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Y11_41001 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Y11_41011 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Y11_41021 ENOG4105CE9 30S ribosomal protein S2 Y11_41031 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Y11_41041 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Y11_41051 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Y11_41061 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Y11_41071 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Y11_41081 ENOG4105KNE Phosphatidate cytidylyltransferase Y11_41091 ENOG4105DZP Membrane-associated zinc metalloprotease Y11_41111 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) Y11_41121 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Y11_41141 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Y11_41151 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Y11_41161 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Y11_41171 ENOG4105C0B DNA polymerase III (alpha subunit) Y11_41181 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Y11_41191 ENOG4105CXN decarboxylase Y11_41201 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase Y11_41211 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Y11_41221 ENOG4105N7H Cytochrome Y11_41231 ENOG4105M1T rho-binding antiterminator Y11_41241 ENOG4105W1I UPF0253 protein Y11_41251 ENOG4108VWS Yaeq family Y11_41261 ENOG4108YZN class I peptide chain release factor Y11_41271 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion Y11_41281 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Y11_41301 ENOG4108R96 Methyltransferase, YaeB family Y11_41311 ENOG4108R8X outer membrane lipoprotein Y11_41321 ENOG4105D01 (LipO)protein Y11_41331 ENOG4108UMI ABC transporter, permease Y11_41351 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Y11_41361 ENOG4105D5G Transposase Y11_41371 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Y11_41381 ENOG4105CV8 reductase Y11_41391 ENOG4105HEI LysR family (Transcriptional regulator Y11_41411 ENOG4105F27 Major Facilitator Y11_41431 ENOG4107NA1 Endonuclease Exonuclease phosphatase Y11_41441 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_41451 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_41461 ENOG4105E9H Lytic Murein transglycosylase Y11_41471 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Y11_41481 ENOG4105D1A Methyltransferase Y11_41491 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Y11_41501 ENOG4108JDX DNA polymerase iii, epsilon subunit Y11_41511 ENOG4105GIJ Glycine betaine Y11_41521 ENOG4108HQS Glycine betaine Y11_41531 ENOG4108IJ7 Glycine betaine Y11_41541 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Y11_41561 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Y11_41591 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Y11_41611 ENOG4105TNS Conserved Protein Y11_41641 ENOG41075H3 AraC family transcriptional regulator Y11_41651 ENOG4105F9N Major Facilitator Superfamily Y11_41661 ENOG4108WMJ Protein of unknown function (DUF2002) Y11_41691 ENOG4105VEQ Cold shock protein Y11_41771 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Y11_41791 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) Y11_41831 ENOG4105KI2 Urea amidohydrolase subunit beta Y11_41841 ENOG4105CQM Urea amidohydrolase subunit alpha Y11_41851 ENOG4108VDS Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Y11_41861 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Y11_41871 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Y11_41881 ENOG4108XNJ Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Y11_41911 ENOG4105XXV Acid-resistance protein Y11_41941 ENOG4107SVH Potassium channel protein Y11_41951 ENOG41086WQ Protein CrcB homolog Y11_41971 ENOG4105CPC Aldo Keto reductase Y11_41981 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_41991 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_42001 ENOG4105D8V Glucose sorbosone dehydrogenase Y11_42011 ENOG4105VZJ PTS System Y11_42021 ENOG4105CK1 PTS System Y11_42031 ENOG4105CS2 ec 3.2.1.21 Y11_42041 ENOG4105VCP PTS System Y11_42051 ENOG4105EZV Transcriptional regulator Y11_42061 ENOG410901P UPF0249 protein Y11_42071 ENOG4105CHH sulfate transporter Y11_42081 ENOG4105D5G Transposase Y11_42091 ENOG4105DFP Integrase Y11_42101 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Y11_42111 ENOG4108Z1B Cyclase dehydrase Y11_42131 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Y11_42141 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Y11_42151 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Y11_42171 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Y11_42181 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Y11_42191 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) Y11_42241 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_42251 ENOG4105EQR Transposase IS116 IS110 IS902 Y11_42261 ENOG4105C1J atp-dependent rna helicase Y11_42271 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Y11_42281 ENOG4108IYU L-aspartate oxidase Y11_42291 ENOG4105EMN RNA polymerase sigma factor Y11_42301 ENOG41069PW sigma-e factor negative regulatory protein Y11_42341 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Y11_42351 ENOG4105C3F Signal peptidase i Y11_42361 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Y11_42371 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Y11_42381 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) Y11_42391 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Y11_42401 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Y11_42411 ENOG4107EFN gluconate transport system permease 3 Y11_42421 ENOG4106G6Q Transcriptional regulator Y11_42441 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB Y11_42461 ENOG4108Z6B deaminase Y11_42471 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) Y11_42511 ENOG4107WP9 Histidine kinase Y11_42521 ENOG4108SKK alpha helix protein Y11_42531 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Y11_42541 ENOG4105C4K Nad synthetase Y11_42551 ENOG4108YZA Nitrogen regulatory protein pii Y11_42561 ENOG4106M0N transport system permease protein Y11_42571 ENOG4105MUZ Protein of unknown function DUF2620 Y11_42581 ENOG41080QX K07048 phosphotriesterase-related protein Y11_42591 ENOG4108626 Racemase Y11_42601 ENOG4105RMW regulation of transcription, DNA-dependent Y11_42611 ENOG4108M21 Y11_42621 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Y11_42631 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Y11_42641 ENOG4105D8G Major Facilitator superfamily Y11_42651 ENOG4108MN2 Stationary phase inducible protein CsiE Y11_42661 ENOG41065CD Exported protein Y11_42671 ENOG4105D7X high-affinity nickel-transporter Y11_42691 ENOG4105CVS RNA methyltransferase TrmH family, group 1 Y11_42701 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Y11_42711 ENOG4105C3J Cysteine desulfurase Y11_42721 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins Y11_42731 ENOG4108Z4V iron-sulfur cluster assembly Y11_42741 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) Y11_42751 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB Y11_42761 ENOG4108ZIT Ferredoxin, 2FE-2S Y11_42771 ENOG4105WVQ Fe-S assembly protein IscX Y11_42791 ENOG4105YYA enhanced serine sensitivity protein SseB Y11_42801 ENOG4108MGN ATP-binding component of a transport system Y11_42841 ENOG4105DN3 alpha-2-macroglobulin domain protein Y11_42851 ENOG4108JQB penicillin-binding protein 1C Y11_42881 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Y11_42901 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) Y11_42911 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Y11_42931 ENOG4105CUT histidyl-tRNA synthetase Y11_42941 ENOG4105N21 Membrane Y11_42951 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) Y11_42971 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Y11_43001 ENOG4105VPD cellular component movement Y11_43011 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Y11_43021 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Y11_43041 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Y11_43141 ENOG4105DWF phosphomethylpyrimidine kinase Y11_43161 ENOG4108ZGU inhibitor of vertebrate lysozyme Y11_43171 ENOG4105C2X Arabinose 5-phosphate isomerase Y11_43181 ENOG410804X Transcriptional regulator Y11_43191 ENOG4105J92 DNA-binding transcriptional activator GutM Y11_43201 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase Y11_43211 ENOG4105VI0 Pts system, glucitol sorbitol-specific Y11_43221 ENOG4105DZY Pts system, glucitol sorbitol-specific Y11_43231 ENOG410787A Pts system, glucitol sorbitol-specific Y11_43241 ENOG4107TE5 Lipid kinase Y11_43251 ENOG4105CFP Peptidase U32 Y11_43261 ENOG4105KWI UPF0339 protein Y11_43271 ENOG4105E3W Two component transcriptional regulator (Winged helix family Y11_43281 ENOG4105EB3 Histidine kinase Y11_43291 ENOG4105C0R drug resistance transporter emrb qaca subfamily Y11_43311 ENOG4105BZS acriflavin resistance protein Y11_43331 ENOG4105ENT Efflux transporter rnd family, mfp subunit Y11_43341 ENOG4105R8A Heat shock protein Y11_43351 ENOG4105BZU Histidine kinase Y11_43371 ENOG4105E2Z phosphate ABC transporter (Permease Y11_43381 ENOG4105C8U phosphate abc transporter Y11_43391 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Y11_43401 ENOG4105C9X ppx gppa phosphatase Y11_43421 ENOG4105CJW magnesium transporter Y11_43431 ENOG4105BZU Histidine kinase Y11_43441 ENOG4108MK9 spermidine N(1)-acetyltransferase Y11_43451 ENOG4108V3E phosphoribosylglycinamide formyltransferase Y11_43461 ENOG4105CXB phosphoribosylaminoimidazole synthetase Y11_43471 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Y11_43481 ENOG4105C2W permease Y11_p0231 ENOG4105DWP Membrane Y11_p0291 ENOG4105KBH arsR family transcriptional regulator Y11_p0301 ENOG4105CAU Arsenical resistance protein, ArsH Y11_p0411 ENOG4105EZN Cobyrinic acid ac-diamide synthase Y11_p0421 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB Y11_p0911 ENOG4105D5G Transposase Y11_p1081 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) Y11_p1091 ENOG4106CQM replication