locus-tag	class	description
Y11_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y11_00011	COG1393	Belongs to the ArsC family
Y11_00021	COG4783	chaperone-mediated protein folding
Y11_00031	COG0628	permease
Y11_00051	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y11_00061	COG2716	regulation of RNA biosynthetic process
Y11_00071	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y11_00081	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Y11_00091	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Y11_00101	COG2321	neutral zinc metallopeptidase
Y11_00111	COG2707	UPF0756 membrane protein
Y11_00121	COG1444	tRNA N-acetyltransferase activity
Y11_00151	COG0400	carboxylic ester hydrolase activity
Y11_00261	COG1876	peptidase activity
Y11_00271	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y11_00281	COG1393	Belongs to the ArsC family
Y11_00321	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_00341	COG2197	response regulator
Y11_00361	COG3062	negative regulation of establishment of protein localization
Y11_00371	COG0243	molybdopterin cofactor binding
Y11_00381	COG3043	anaerobic respiration
Y11_00391	COG3005	denitrification pathway
Y11_00401	COG0494	nUDIX hydrolase
Y11_00411	COG0280	phosphate acetyltransferase
Y11_00411	COG0281	malic enzyme
Y11_00451	COG1671	Belongs to the UPF0178 family
Y11_00461	COG0408	coproporphyrinogen oxidase activity
Y11_00471	COG0456	acetyltransferase
Y11_00481	COG3111	PFAM Bacterial OB fold (BOF) protein
Y11_00501	COG2837	iron assimilation
Y11_00531	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y11_00571	COG2731	YhcH YjgK YiaL family protein
Y11_00581	COG1737	Transcriptional regulator
Y11_00611	COG4150	thiosulfate binding
Y11_00621	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Y11_00631	COG4208	sulfate ABC transporter
Y11_00681	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_00691	COG0745	RESPONSE REGULATOR receiver
Y11_00701	COG0745	RESPONSE REGULATOR receiver
Y11_00711	COG2205	protein histidine kinase activity
Y11_00721	COG2190	(PTS) system
Y11_00731	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y11_00741	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_00751	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Y11_00781	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_00791	COG3530	Putative quorum-sensing-regulated virulence factor
Y11_00831	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y11_00841	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y11_00851	COG1914	H( )-stimulated, divalent metal cation uptake system
Y11_00871	COG0667	Aldo Keto reductase
Y11_00891	COG3961	Belongs to the TPP enzyme family
Y11_00921	COG0837	glucose binding
Y11_00931	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_00941	COG2223	nitrite transmembrane transporter activity
Y11_00951	COG3279	Response regulator of the LytR AlgR family
Y11_00961	COG3275	phosphorelay sensor kinase activity
Y11_00991	COG0436	Aminotransferase
Y11_01001	COG3038	cytochrome b561
Y11_01011	COG1598	PFAM Uncharacterised protein family UPF0150
Y11_01041	COG1280	lysine exporter protein (LysE YggA)
Y11_01081	COG2951	lytic endotransglycosylase activity
Y11_01091	COG0531	amino acid
Y11_01131	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y11_01141	COG1127	ABC transporter
Y11_01181	COG0657	acetylesterase activity
Y11_01181	COG2755	lipolytic protein G-D-S-L family
Y11_01191	COG3038	cytochrome b561
Y11_01201	COG2353	YceI-like domain
Y11_01211	COG2353	YceI-like domain
Y11_01221	COG1609	Transcriptional regulator
Y11_01231	COG1263	PTS System
Y11_01231	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_01241	COG2723	6-phospho-beta-galactosidase activity
Y11_01261	COG1695	Transcriptional regulator
Y11_01271	COG2824	Alkylphosphonate utilization operon protein PhnA
Y11_01291	COG2116	formate transmembrane transporter activity
Y11_01311	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y11_01331	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y11_01341	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Y11_01351	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Y11_01361	COG1138	Cytochrome C-type biogenesis protein
Y11_01371	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y11_01391	COG3088	subunit of a heme lyase
Y11_01391	COG4235	cytochrome complex assembly
Y11_01421	COG3691	Protein conserved in bacteria
Y11_01431	COG0183	Belongs to the thiolase family
Y11_01441	COG1250	3-hydroxyacyl-CoA dehydrogenase
Y11_01441	COG1024	Enoyl-CoA hydratase
Y11_01451	COG2062	phosphohistidine phosphatase, SixA
Y11_01461	COG2840	Smr protein MutS2
Y11_01471	COG2890	protein-(glutamine-N5) methyltransferase activity
Y11_01481	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Y11_01491	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Y11_01501	COG0730	response to heat
Y11_01511	COG3101	peptidyl-lysine hydroxylation
Y11_01531	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Y11_01531	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y11_01541	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y11_01551	COG3706	GGDEF domain
Y11_01571	COG1794	racemase activity, acting on amino acids and derivatives
Y11_01591	COG1447	Phosphotransferase system cellobiose-specific component IIA
Y11_01601	COG2723	6-phospho-beta-galactosidase activity
Y11_01611	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_01631	COG1609	Transcriptional regulator
Y11_01651	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Y11_01711	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y11_01721	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_01731	COG0697	spore germination
Y11_01741	COG0697	spore germination
Y11_01761	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y11_01771	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y11_01791	COG0586	Pfam SNARE associated Golgi protein
Y11_01801	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Y11_01821	COG0285	dihydrofolate synthase activity
Y11_01831	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Y11_01841	COG1286	toxin biosynthetic process
Y11_01851	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Y11_01861	COG0163	prenyltransferase activity
Y11_01871	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_01881	COG4215	(ABC) transporter
Y11_01891	COG4160	amino acid transport
Y11_01901	COG4598	ABC transporter
Y11_01931	COG1090	epimerase
Y11_01951	COG0622	Phosphoesterase
Y11_01961	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Y11_01991	COG3037	sugar-specific permease SgaT UlaA
Y11_02011	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_02021	COG1609	Transcriptional regulator
Y11_02031	COG0857	belongs to the CobB CobQ family
Y11_02031	COG0280	phosphate acetyltransferase
Y11_02061	COG3092	negative regulation of chromosome organization
Y11_02071	COG3013	Belongs to the UPF0304 family
Y11_02081	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_02111	COG0471	metal ion transport
Y11_02111	COG0490	domain, Protein
Y11_02121	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Y11_02131	COG0436	Aminotransferase
Y11_02141	COG0583	DNA-binding transcription factor activity
Y11_02151	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_02161	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_02171	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_02171	COG0649	NAD binding
Y11_02181	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Y11_02201	COG1034	ATP synthesis coupled electron transport
Y11_02211	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Y11_02221	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_02231	COG0839	Belongs to the complex I subunit 6 family
Y11_02241	COG0713	ATP synthesis coupled electron transport
Y11_02251	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y11_02261	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_02271	COG1007	ATP synthesis coupled electron transport
Y11_02321	COG3265	gluconokinase activity
Y11_02331	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_02351	COG1609	Transcriptional regulator
Y11_02361	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y11_02371	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y11_02391	COG4702	Belongs to the UPF0303 family
Y11_02401	COG0129	dihydroxy-acid dehydratase activity
Y11_02411	COG4575	ribosome binding
Y11_02421	COG1169	isochorismate synthase
Y11_02441	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Y11_02451	COG0596	Alpha beta hydrolase
Y11_02461	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Y11_02471	COG1441	menaquinone biosynthetic process
Y11_02521	COG0814	amino acid
Y11_02591	COG4574	serine-type endopeptidase inhibitor activity
Y11_02601	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y11_02621	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y11_02631	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y11_02651	COG2205	protein histidine kinase activity
Y11_02651	COG0784	Response regulator, receiver
Y11_02661	COG2197	response regulator
Y11_02671	COG0642	Histidine kinase
Y11_02671	COG2198	Histidine kinase
Y11_02681	COG2223	nitrite transmembrane transporter activity
Y11_02741	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Y11_02761	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Y11_02871	COG1737	Transcriptional regulator
Y11_02891	COG1263	PTS System
Y11_02891	COG2190	(PTS) system
Y11_02891	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_02901	COG2723	6-phospho-beta-galactosidase activity
Y11_02921	COG3328	transposase activity
Y11_02961	COG3082	Protein of unknown function (DUF1414)
Y11_02971	COG3081	Nucleoid-associated protein
Y11_02981	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Y11_02991	COG1061	Type III restriction enzyme res subunit
Y11_03001	COG1187	pseudouridine synthase activity
Y11_03011	COG2814	Major facilitator Superfamily
Y11_03031	COG4172	Belongs to the ABC transporter superfamily
Y11_03041	COG4239	(ABC) transporter, permease
Y11_03051	COG4174	ABC transporter (Permease)
Y11_03061	COG4166	transmembrane transport
Y11_03071	COG2200	EAL domain
Y11_03081	COG0791	NLP P60 protein
Y11_03091	COG0671	phosphoesterase, PA-phosphatase related
Y11_03101	COG0523	cobalamin synthesis protein
Y11_03121	COG2186	Transcriptional regulator
Y11_03131	COG0246	Mannitol dehydrogenase
Y11_03151	COG1312	Catalyzes the dehydration of D-mannonate
Y11_03161	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Y11_03201	COG0243	molybdopterin cofactor binding
Y11_03211	COG3005	denitrification pathway
Y11_03251	COG1105	Belongs to the carbohydrate kinase PfkB family
Y11_03261	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Y11_03261	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Y11_03261	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Y11_03271	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Y11_03271	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Y11_03271	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Y11_03281	COG3710	Transcriptional regulator
Y11_03341	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Y11_03351	COG2855	membrane
Y11_03381	COG0583	DNA-binding transcription factor activity
Y11_03391	COG0833	amino acid
Y11_03401	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y11_03421	COG4771	TonB-dependent receptor
Y11_03431	COG0625	glutathione transferase activity
Y11_03491	COG2011	ABC-type metal ion transport system permease component
Y11_03501	COG0626	cystathionine gamma-synthase activity
Y11_03521	COG1686	Belongs to the peptidase S11 family
Y11_03531	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_03541	COG1760	l-serine dehydratase
Y11_03551	COG0814	amino acid
Y11_03561	COG1349	DNA-binding transcription factor activity
Y11_03571	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Y11_03581	COG0671	phosphoesterase, PA-phosphatase related
Y11_03601	COG2985	domain, Protein
Y11_03601	COG0569	domain protein
Y11_03611	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Y11_03641	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Y11_03661	COG3842	ATPase activity
Y11_03671	COG1176	ABC-type spermidine putrescine transport system, permease component I
Y11_03681	COG1177	transmembrane transport
Y11_03711	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y11_03721	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_03741	COG4160	amino acid transport
Y11_03751	COG4215	(ABC) transporter
Y11_03761	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_03771	COG1126	abc transporter atp-binding protein
Y11_03791	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_03801	COG0702	epimerase
Y11_03811	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Y11_03831	COG0028	Belongs to the TPP enzyme family
Y11_03841	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y11_03851	COG1151	hydroxylamine reductase activity
Y11_03861	COG2431	L-lysine efflux transmembrane transporter activity
Y11_03871	COG3593	DNA synthesis involved in DNA repair
Y11_03881	COG2990	Protein conserved in bacteria
Y11_03891	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_03911	COG1278	Cold shock
Y11_03921	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Y11_03931	COG0542	response to heat
Y11_03941	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Y11_03951	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Y11_03961	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Y11_03981	COG0492	ferredoxin-NADP+ reductase activity
Y11_03991	COG1522	sequence-specific DNA binding
Y11_04001	COG3107	peptidoglycan biosynthetic process
Y11_04001	COG1674	ftsk spoiiie
Y11_04011	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Y11_04021	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y11_04031	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Y11_04041	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_04051	COG3328	transposase activity
Y11_04061	COG2814	Major facilitator Superfamily
Y11_04071	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Y11_04081	COG1882	Formate acetyltransferase
Y11_04091	COG2116	formate transmembrane transporter activity
Y11_04141	COG1944	ATP diphosphatase activity
Y11_04151	COG0252	asparaginase activity
Y11_04161	COG0252	asparaginase activity
Y11_04171	COG2323	membrane
Y11_04181	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Y11_04191	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Y11_04201	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Y11_04211	COG0539	negative regulation of cytoplasmic translation
Y11_04221	COG0776	regulation of translation
Y11_04231	COG0658	competence protein
Y11_04231	COG2333	competence protein COMEC
Y11_04251	COG1663	tetraacyldisaccharide 4'-kinase activity
Y11_04261	COG5383	Protein conserved in bacteria
Y11_04271	COG1278	Cold shock
Y11_04291	COG1278	Cold shock
Y11_04301	COG2835	tetraacyldisaccharide 4'-kinase activity
Y11_04311	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Y11_04321	COG3173	Aminoglycoside phosphotransferase
Y11_04331	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Y11_04351	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y11_04361	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Y11_04371	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Y11_04381	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Y11_04391	COG2989	Protein conserved in bacteria
Y11_04401	COG3108	Peptidase M15
Y11_04411	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y11_04421	COG2200	EAL domain
Y11_04431	COG1448	Aminotransferase
Y11_04451	COG0017	Asparaginyl-tRNA synthetase
Y11_04461	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Y11_04471	COG0308	aminopeptidase N
Y11_04481	COG0167	dihydroorotate dehydrogenase activity
Y11_04511	COG0633	Ferredoxin
Y11_04511	COG3217	Mosc domain protein beta barrel domain protein
Y11_04521	COG0116	Belongs to the methyltransferase superfamily
Y11_04521	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y11_04531	COG0488	(ABC) transporter
Y11_04541	COG2995	paraquat-inducible protein a
Y11_04551	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Y11_04551	COG3008	intermembrane lipid transfer
Y11_04561	COG3009	Protein conserved in bacteria
Y11_04571	COG3130	regulation of translation
Y11_04581	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y11_04601	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y11_04611	COG1067	ATP-dependent peptidase activity
Y11_04621	COG3120	sequence-specific DNA binding
Y11_04631	COG2885	chlorophyll binding
Y11_04631	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y11_04641	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Y11_04651	COG3070	regulator of competence-specific genes
Y11_04671	COG1289	transmembrane transporter activity
Y11_04681	COG3304	Inner membrane component domain
Y11_04691	COG0210	DNA helicase
Y11_04701	COG1803	Methylglyoxal synthase
Y11_04711	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Y11_04721	COG1832	CoA-binding protein
Y11_04731	COG3785	DNA binding
Y11_04741	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y11_04771	COG1254	Belongs to the acylphosphatase family
Y11_04781	COG2920	part of a sulfur-relay system
Y11_04811	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Y11_04821	COG0437	4 iron, 4 sulfur cluster binding
Y11_04831	COG3301	Polysulphide reductase, NrfD
Y11_04841	COG1138	Cytochrome C-type biogenesis protein
Y11_04851	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Y11_04861	COG3088	subunit of a heme lyase
Y11_04871	COG4235	cytochrome complex assembly
Y11_04881	COG2771	luxR family
Y11_04891	COG3916	Acyl-homoserine-lactone synthase
Y11_04921	COG3263	regulation of cellular component size
Y11_04961	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Y11_04971	COG2943	transferase activity, transferring hexosyl groups
Y11_04981	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_04991	COG3104	oligopeptide transport
Y11_05001	COG2814	Major facilitator Superfamily
Y11_05011	COG2259	Doxx family
Y11_05041	COG1560	Kdo2-lipid A biosynthetic process
Y11_05121	COG0628	permease
Y11_05181	COG0418	dihydroorotase activity
Y11_05191	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Y11_05201	COG1530	ribonuclease E activity
Y11_05201	COG1530	ribonuclease E activity
Y11_05211	COG0564	pseudouridine synthase activity
Y11_05231	COG1399	metal-binding, possibly nucleic acid-binding protein
Y11_05241	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Y11_05251	COG0416	fatty acid biosynthetic process
Y11_05261	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Y11_05271	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Y11_05281	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_05301	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y11_05311	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y11_05321	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Y11_05331	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y11_05341	COG0470	DNA polymerase III
Y11_05351	COG0084	hydrolase, TatD family'
Y11_05361	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_05361	COG1263	PTS System
Y11_05401	COG0641	radical SAM
Y11_05431	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Y11_05441	COG0537	adenosine 5'-monophosphoramidase activity
Y11_05451	COG5633	Lipoprotein
Y11_05461	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
Y11_05481	COG1472	Belongs to the glycosyl hydrolase 3 family
Y11_05491	COG3150	esterase
Y11_05501	COG1252	NADH dehydrogenase
Y11_05511	COG3134	Outer membrane lipoprotein
Y11_05521	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y11_05531	COG4591	ABC-type transport system involved in lipoprotein release permease component
Y11_05551	COG4591	ABC-type transport system involved in lipoprotein release permease component
Y11_05561	COG1940	carbohydrate kinase activity
Y11_05571	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Y11_05591	COG2850	peptidyl-arginine hydroxylation
Y11_05611	COG0745	RESPONSE REGULATOR receiver
Y11_05631	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y11_05641	COG2915	High frequency lysogenization protein hflD homolog
Y11_05651	COG0482	sulfurtransferase activity
Y11_05671	COG1187	pseudouridine synthase activity
Y11_05681	COG0538	isocitrate dehydrogenase activity
Y11_05751	COG0538	isocitrate dehydrogenase activity
Y11_05831	COG0840	transmembrane signaling receptor activity
Y11_05871	COG2873	o-acetylhomoserine
Y11_05881	COG0702	epimerase
Y11_05891	COG1733	regulation of RNA biosynthetic process
Y11_05941	COG0697	spore germination
Y11_05971	COG3755	Protein conserved in bacteria
Y11_06001	COG5001	Diguanylate cyclase
Y11_06001	COG2203	Gaf domain
Y11_06001	COG4251	negative regulation of phosphorylation
Y11_06001	COG3706	GGDEF domain
Y11_06031	COG1132	(ABC) transporter
Y11_06081	COG2207	Transcriptional regulator
Y11_06161	COG1113	amino acid transport
Y11_06201	COG0768	penicillin binding
Y11_06211	COG0768	penicillin binding
Y11_06221	COG2226	methyltransferase
Y11_06241	COG3447	MASE1 domain protein
Y11_06241	COG5001	Diguanylate cyclase
Y11_06241	COG5002	protein histidine kinase activity
Y11_06261	COG1971	Probably functions as a manganese efflux pump
Y11_06271	COG4811	Protein of unknown function (DUF986)
Y11_06281	COG3716	PTS system mannose fructose sorbose family IID component
Y11_06291	COG3715	PTS system
Y11_06301	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_06301	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_06321	COG1253	flavin adenine dinucleotide binding
Y11_06341	COG1760	l-serine dehydratase
Y11_06361	COG0494	nUDIX hydrolase
Y11_06381	COG3140	Belongs to the UPF0181 family
Y11_06391	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Y11_06401	COG0513	Belongs to the DEAD box helicase family
Y11_06411	COG3141	response to X-ray
Y11_06441	COG1770	oligopeptidase
Y11_06451	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Y11_06491	COG1528	Iron-storage protein
Y11_06511	COG2372	response to copper ion
Y11_06521	COG1276	copper resistance
Y11_06541	COG4974	Belongs to the 'phage' integrase family
Y11_06641	COG3328	transposase activity
Y11_06651	COG0500	methyltransferase
Y11_06661	COG3328	transposase activity
Y11_06681	COG0561	phosphatase activity
Y11_06691	COG2223	nitrite transmembrane transporter activity
Y11_06731	COG3493	citrate carrier protein
Y11_06741	COG4565	transcriptional regulatory protein
Y11_06751	COG3290	protein histidine kinase activity
Y11_06761	COG1349	DNA-binding transcription factor activity
Y11_06771	COG3395	kinase activity
Y11_06781	COG0235	Class ii aldolase
Y11_06791	COG0235	Class ii aldolase
Y11_06801	COG3622	Belongs to the hyi family
Y11_06811	COG2066	Belongs to the glutaminase family
Y11_06841	COG0672	)-iron permease
Y11_06871	COG0577	efflux transmembrane transporter activity
Y11_06871	COG1136	(ABC) transporter
Y11_06901	COG1136	(ABC) transporter
Y11_06901	COG0577	efflux transmembrane transporter activity
Y11_06951	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y11_06961	COG4114	ferric iron reductase
Y11_06971	COG0006	proline dipeptidase activity
Y11_06981	COG0457	Tetratricopeptide repeat
Y11_06991	COG0457	Tetratricopeptide repeat
Y11_07001	COG1649	PFAM Uncharacterised BCR, COG1649
Y11_07001	COG0726	polysaccharide deacetylase
Y11_07011	COG1215	transferase activity, transferring glycosyl groups
Y11_07021	COG3658	cytochrome
Y11_07051	COG1702	phosphate starvation-inducible protein PhoH
Y11_07081	COG0018	arginyl-trna synthetase
Y11_07091	COG3102	Protein conserved in bacteria
Y11_07101	COG3142	Participates in the control of copper homeostasis
Y11_07181	COG0668	transmembrane transport
Y11_07191	COG0625	glutathione transferase activity
Y11_07261	COG5001	Diguanylate cyclase
Y11_07331	COG2814	Major facilitator Superfamily
Y11_07351	COG3008	intermembrane lipid transfer
Y11_07361	COG2995	paraquat-inducible protein a
Y11_07371	COG1956	GAF domain-containing protein
Y11_07391	COG0793	Belongs to the peptidase S41A family
Y11_07401	COG0501	Belongs to the peptidase M48B family
Y11_07421	COG2814	Major facilitator Superfamily
Y11_07431	COG0823	Involved in the tonB-independent uptake of proteins
Y11_07451	COG3023	N-Acetylmuramoyl-L-alanine amidase
Y11_07501	COG1988	membrane-bound metal-dependent
Y11_07511	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y11_07531	COG1653	transport
Y11_07541	COG3842	ATPase activity
Y11_07551	COG0395	ABC-type sugar transport system, permease component
Y11_07561	COG1175	transmembrane transport
Y11_07591	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_07601	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Y11_07611	COG1917	Cupin 2, conserved barrel domain protein
Y11_07621	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_07641	COG0583	DNA-binding transcription factor activity
Y11_07651	COG0427	acetyl-CoA hydrolase
Y11_07661	COG1024	Enoyl-CoA hydratase
Y11_07671	COG1703	isobutyryl-CoA mutase activity
Y11_07681	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y11_07681	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y11_07701	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_07711	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_07721	COG1121	(ABC) transporter
Y11_07731	COG0803	Belongs to the bacterial solute-binding protein 9 family
Y11_07821	COG1811	Na channel or pump
Y11_07831	COG4249	Peptidase C14 caspase catalytic subunit p20
Y11_07851	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Y11_07861	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Y11_07871	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Y11_07881	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Y11_07891	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Y11_07911	COG0776	regulation of translation
Y11_07951	COG4139	cobalamin transport
Y11_07961	COG0386	Belongs to the glutathione peroxidase family
Y11_07971	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Y11_07981	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Y11_07991	COG0463	Glycosyl transferase, family 2
Y11_08001	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y11_08001	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_08011	COG0726	polysaccharide deacetylase
Y11_08021	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Y11_08031	COG2076	Multidrug Resistance protein
Y11_08041	COG2076	Multidrug Resistance protein
Y11_08051	COG0791	NLP P60 protein
Y11_08061	COG0095	Lipoate-protein ligase
Y11_08081	COG4558	Periplasmic binding protein
Y11_08091	COG3720	iron ion transport
Y11_08131	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Y11_08141	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y11_08141	COG0574	Belongs to the PEP-utilizing enzyme family
Y11_08151	COG0628	permease
Y11_08161	COG0247	lactate metabolic process
Y11_08161	COG0277	FAD linked oxidase domain protein
Y11_08171	COG2050	protein possibly involved in aromatic compounds catabolism
Y11_08181	COG0316	Belongs to the HesB IscA family
Y11_08191	COG0719	Fe-S assembly protein
Y11_08201	COG0396	ATPase activity
Y11_08211	COG0719	Fe-S assembly protein
Y11_08231	COG2166	iron-sulfur cluster assembly
Y11_08241	COG1388	LysM domain
Y11_08241	COG1376	ErfK ybiS ycfS ynhG family protein
Y11_08261	COG0534	Mate efflux family protein
Y11_08271	COG0307	riboflavin synthase, alpha
Y11_08281	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Y11_08291	COG2814	Major facilitator Superfamily
Y11_08301	COG0583	DNA-binding transcription factor activity
Y11_08311	COG1609	Transcriptional regulator
Y11_08321	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Y11_08331	COG0791	NLP P60 protein
Y11_08341	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Y11_08351	COG0346	lactoylglutathione lyase activity
Y11_08361	COG1902	pentaerythritol trinitrate reductase activity
Y11_08371	COG1309	transcriptional regulator
Y11_08381	COG2194	sulfuric ester hydrolase activity
Y11_08391	COG3313	Fe-S protein
Y11_08401	COG4989	oxidoreductase activity
Y11_08411	COG1289	transmembrane transporter activity
Y11_08421	COG1566	PFAM secretion protein HlyD family protein
Y11_08441	COG1846	Transcriptional regulator
Y11_08451	COG3133	Outer membrane lipoprotein
Y11_08471	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Y11_08481	COG3895	Periplasmic Protein
Y11_08491	COG0259	pyridoxamine-phosphate oxidase activity
Y11_08501	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Y11_08521	COG0625	glutathione transferase activity
Y11_08571	COG3104	oligopeptide transport
Y11_08601	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y11_08601	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y11_08621	COG4172	Belongs to the ABC transporter superfamily
Y11_08641	COG4171	peptide transport system, permease
Y11_08651	COG4168	peptide transport system, permease
Y11_08661	COG4166	transmembrane transport
Y11_08671	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_08701	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Y11_08711	COG1842	Phage shock protein A
Y11_08731	COG1983	PspC domain protein
Y11_08751	COG3106	COG3106 Predicted ATPase
Y11_08761	COG3768	UPF0283 membrane protein
Y11_08791	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Y11_08801	COG4948	Mandelate Racemase Muconate Lactonizing
Y11_08811	COG2866	Carboxypeptidase
Y11_08821	COG4166	transmembrane transport
Y11_08831	COG0598	Magnesium transport protein CorA
Y11_08841	COG0037	tRNA processing
Y11_08861	COG0823	Involved in the tonB-independent uptake of proteins
Y11_08871	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_08871	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Y11_08871	COG1013	pyruvate-flavodoxin oxidoreductase activity
Y11_08871	COG0674	pyruvate-flavodoxin oxidoreductase activity
Y11_08901	COG1285	pathogenesis
Y11_08911	COG3042	response to heat
Y11_08921	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y11_08931	COG2911	Protein conserved in bacteria
Y11_08951	COG3784	Protein of unknown function (DUF1318)
Y11_08961	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Y11_08971	COG1643	Atp-dependent helicase
Y11_09001	COG3591	Belongs to the peptidase S1B family
Y11_09021	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Y11_09041	COG2205	protein histidine kinase activity
Y11_09051	COG0745	RESPONSE REGULATOR receiver
Y11_09071	COG0531	amino acid
Y11_09101	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Y11_09111	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Y11_09121	COG0589	response to stress
Y11_09131	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Y11_09141	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y11_09171	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Y11_09181	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_09201	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_09211	COG0738	Major facilitator superfamily
Y11_09251	COG1011	Hydrolase
Y11_09261	COG0440	acetolactate synthase activity
Y11_09271	COG0028	Belongs to the TPP enzyme family
Y11_09291	COG3023	N-Acetylmuramoyl-L-alanine amidase
Y11_09381	COG0483	inositol monophosphate 1-phosphatase activity
Y11_09411	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Y11_09431	COG3177	Filamentation induced by cAMP protein fic
Y11_09501	COG4215	(ABC) transporter
Y11_09521	COG1522	sequence-specific DNA binding
Y11_09571	COG0625	glutathione transferase activity
Y11_09601	COG4128	Pfam Zonular occludens toxin
Y11_09781	COG4221	oxidoreductase activity
Y11_09791	COG1742	UPF0060 membrane protein
Y11_09851	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Y11_09861	COG1940	carbohydrate kinase activity
Y11_09871	COG0583	DNA-binding transcription factor activity
Y11_09881	COG2814	Major facilitator Superfamily
Y11_09941	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_09961	COG0114	fumarate hydratase activity
Y11_09981	COG5339	Protein conserved in bacteria
Y11_10001	COG1609	Transcriptional regulator
Y11_10011	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_10011	COG1263	PTS System
Y11_10021	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Y11_10031	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Y11_10041	COG0385	Bile acid
Y11_10051	COG0673	inositol 2-dehydrogenase activity
Y11_10071	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_10081	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_10101	COG1879	ABC-type sugar transport system periplasmic component
Y11_10121	COG2160	L-arabinose isomerase activity
Y11_10131	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Y11_10141	COG2274	protein secretion by the type I secretion system
Y11_10161	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_10191	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Y11_10211	COG4657	Part of a membrane complex involved in electron transport
Y11_10231	COG4656	Part of a membrane complex involved in electron transport
Y11_10261	COG3708	Transcriptional regulator
Y11_10261	COG2207	Transcriptional regulator
Y11_10281	COG4658	electron transport chain
Y11_10291	COG4659	FMN binding
Y11_10311	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y11_10361	COG0243	molybdopterin cofactor binding
Y11_10381	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Y11_10401	COG1966	Carbon starvation protein
Y11_10421	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y11_10431	COG1349	DNA-binding transcription factor activity
Y11_10451	COG0235	Class ii aldolase
Y11_10491	COG0023	Translation Initiation Factor
Y11_10501	COG0284	orotidine-5'-phosphate decarboxylase activity
Y11_10521	COG3135	benzoate transporter
Y11_10531	COG3135	benzoate transporter
Y11_10541	COG1396	sequence-specific DNA binding
Y11_10561	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Y11_10571	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Y11_10581	COG0671	phosphoesterase, PA-phosphatase related
Y11_10591	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y11_10631	COG0583	DNA-binding transcription factor activity
Y11_10641	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y11_10671	COG0616	signal peptide processing
Y11_10681	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_10691	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Y11_10711	COG1187	pseudouridine synthase activity
Y11_10721	COG0009	L-threonylcarbamoyladenylate synthase
Y11_10731	COG0613	PHP domain protein
Y11_10761	COG0512	Glutamine amidotransferase of anthranilate synthase
Y11_10781	COG0134	indole-3-glycerol-phosphate synthase activity
Y11_10781	COG0135	phosphoribosylanthranilate isomerase activity
Y11_10791	COG0133	tryptophan synthase activity
Y11_10801	COG0159	tryptophan synthase activity
Y11_10821	COG3047	cAMP biosynthetic process
Y11_10861	COG2917	probably involved in intracellular septation
Y11_10871	COG1607	acyl-coa hydrolase
Y11_10881	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Y11_10891	COG2350	Protein conserved in bacteria
Y11_10931	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y11_10941	COG3099	Belongs to the UPF0263 family
Y11_10961	COG0444	Belongs to the ABC transporter superfamily
Y11_10971	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_11011	COG2095	MarC family integral membrane protein
Y11_11021	COG1454	alcohol dehydrogenase
Y11_11021	COG1012	belongs to the aldehyde dehydrogenase family
Y11_11031	COG1435	thymidine kinase activity
Y11_11041	COG2916	Histone family protein nucleoid-structuring protein H-NS
Y11_11061	COG0745	RESPONSE REGULATOR receiver
Y11_11071	COG0745	RESPONSE REGULATOR receiver
Y11_11081	COG1752	Esterase of the alpha-beta hydrolase superfamily
Y11_11121	COG3012	SEC-C Motif Domain Protein
Y11_11131	COG0788	formyltetrahydrofolate deformylase activity
Y11_11141	COG0583	DNA-binding transcription factor activity
Y11_11161	COG0708	Exodeoxyribonuclease III
Y11_11171	COG0494	nUDIX hydrolase
Y11_11191	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y11_11211	COG0778	Nitroreductase
Y11_11221	COG0616	signal peptide processing
Y11_11231	COG0252	asparaginase activity
Y11_11241	COG1335	isochorismatase
Y11_11271	COG3139	Protein of unknown function (DUF1315)
Y11_11281	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y11_11321	COG3713	MltA-interacting MipA family protein
Y11_11331	COG2766	serine protein kinase
Y11_11341	COG2718	Belongs to the UPF0229 family
Y11_11371	COG0583	DNA-binding transcription factor activity
Y11_11391	COG2202	Pas domain
Y11_11391	COG2199	diguanylate cyclase activity
Y11_11391	COG2200	EAL domain
Y11_11401	COG2814	Major facilitator Superfamily
Y11_11411	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y11_11421	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Y11_11441	COG2719	SpoVR family
Y11_11451	COG2186	Transcriptional regulator
Y11_11471	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Y11_11491	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Y11_11541	COG2983	Belongs to the UPF0260 family
Y11_11551	COG0179	Fumarylacetoacetate (FAA) hydrolase
Y11_11561	COG2951	lytic endotransglycosylase activity
Y11_11571	COG3100	YcgL domain-containing protein
Y11_11591	COG0850	regulation of cytokinetic process
Y11_11601	COG2894	cell division
Y11_11611	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Y11_11621	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Y11_11631	COG0318	PFAM AMP-dependent synthetase and ligase
Y11_11641	COG3065	identical protein binding
Y11_11661	COG1199	ATP-dependent helicase activity
Y11_11671	COG0251	oxidation-reduction process
Y11_11681	COG2076	Multidrug Resistance protein
Y11_11691	COG2076	Multidrug Resistance protein
Y11_11711	COG0800	Aldolase
Y11_11721	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Y11_11731	COG1737	Transcriptional regulator
Y11_11741	COG0469	pyruvate kinase activity
Y11_11761	COG1560	Kdo2-lipid A biosynthetic process
Y11_11771	COG0739	heme binding
Y11_11781	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Y11_11791	COG1121	(ABC) transporter
Y11_11801	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_11811	COG3104	oligopeptide transport
Y11_11821	COG2255	four-way junction helicase activity
Y11_11831	COG0632	four-way junction helicase activity
Y11_11841	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Y11_11851	COG0217	transcriptional regulatory protein
Y11_11861	COG0494	nUDIX hydrolase
Y11_11871	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Y11_11901	COG1335	isochorismatase
Y11_11911	COG1801	Protein of unknown function DUF72
Y11_11921	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Y11_11931	COG2226	methyltransferase
Y11_11941	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Y11_11961	COG1349	DNA-binding transcription factor activity
Y11_11981	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_12001	COG3716	PTS system mannose fructose sorbose family IID component
Y11_12011	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_12021	COG2222	sugar isomerase
Y11_12051	COG4942	peptidase
Y11_12121	COG3443	Belongs to the bacterial solute-binding protein 9 family
Y11_12141	COG0402	S-adenosylhomocysteine deaminase activity
Y11_12161	COG1228	amidohydrolase
Y11_12211	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_12221	COG2988	succinylglutamate desuccinylase activity
Y11_12231	COG3724	N-succinylarginine dihydrolase activity
Y11_12241	COG3724	N-succinylarginine dihydrolase activity
Y11_12261	COG3138	arginine N-succinyltransferase
Y11_12271	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Y11_12281	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_12291	COG1271	oxidase subunit
Y11_12301	COG1294	oxidase, subunit
Y11_12321	COG3850	Histidine kinase
Y11_12331	COG0583	DNA-binding transcription factor activity
Y11_12341	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_12351	COG2814	Major facilitator Superfamily
Y11_12371	COG0387	Pfam Sodium calcium exchanger
Y11_12381	COG0728	peptidoglycan biosynthetic process
Y11_12391	COG0673	inositol 2-dehydrogenase activity
Y11_12411	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y11_12431	COG0477	Major facilitator Superfamily
Y11_12451	COG3381	protein complex oligomerization
Y11_12461	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Y11_12471	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y11_12491	COG3706	GGDEF domain
Y11_12501	COG0659	secondary active sulfate transmembrane transporter activity
Y11_12511	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Y11_12521	COG2912	Transglutaminase-like superfamily
Y11_12531	COG3094	Invasion gene expression up-regulator, SirB
Y11_12541	COG2890	protein-(glutamine-N5) methyltransferase activity
Y11_12551	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Y11_12561	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Y11_12571	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Y11_12591	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Y11_12621	COG0193	aminoacyl-tRNA hydrolase activity
Y11_12641	COG0012	GTP binding
Y11_12671	COG2979	Protein of unknown function (DUF533)
Y11_12691	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Y11_12701	COG3772	lysozyme
Y11_12771	COG2963	transposase activity
Y11_12781	COG2801	Transposase and inactivated derivatives
Y11_12961	COG3077	Addiction module antitoxin, RelB DinJ family
Y11_13051	COG3328	transposase activity
Y11_13091	COG4974	Belongs to the 'phage' integrase family
Y11_13111	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_13221	COG4695	Portal protein
Y11_13531	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Y11_13541	COG0322	excinuclease ABC activity
Y11_13551	COG2197	response regulator
Y11_13571	COG3136	membrane protein required for alginate biosynthesis
Y11_13591	COG0366	Alpha amylase catalytic
Y11_13621	COG2226	methyltransferase
Y11_13641	COG2963	transposase activity
Y11_13651	COG1113	amino acid transport
Y11_13661	COG1309	transcriptional regulator
Y11_13681	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y11_13691	COG1335	isochorismatase
Y11_13701	COG0251	oxidation-reduction process
Y11_13711	COG2267	carboxylic ester hydrolase activity
Y11_13721	COG2267	carboxylic ester hydrolase activity
Y11_13731	COG0778	Nitroreductase
Y11_13741	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Y11_13751	COG2233	PERMEase
Y11_13761	COG2233	PERMEase
Y11_13781	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Y11_13801	COG0655	NAD(P)H dehydrogenase (quinone) activity
Y11_13861	COG3157	Type VI secretion system effector, Hcp
Y11_13911	COG0506	proline dehydrogenase activity
Y11_13911	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Y11_13911	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Y11_13971	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Y11_14001	COG1191	sigma factor activity
Y11_14111	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y11_14121	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Y11_14181	COG0582	viral genome integration into host DNA
Y11_14191	COG1677	Flagellar hook-basal body complex protein FliE
Y11_14211	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y11_14221	COG1317	bacterial-type flagellum organization
Y11_14241	COG2882	bacterial-type flagellum organization
Y11_14261	COG1580	Controls the rotational direction of flagella during chemotaxis
Y11_14301	COG1338	Plays a role in the flagellum-specific transport system
Y11_14351	COG1256	bacterial-type flagellum assembly
Y11_14391	COG4786	Flagellar basal body rod
Y11_14411	COG1749	Flagellar hook protein flgE
Y11_14421	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y11_14431	COG1558	bacterial-type flagellum-dependent cell motility
Y11_14441	COG1815	bacterial-type flagellum-dependent cell motility
Y11_14461	COG2747	anti-sigma28 factor FlgM
Y11_14471	COG3418	PFAM FlgN family protein
Y11_14491	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_14521	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y11_14531	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y11_14551	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Y11_14561	COG0745	RESPONSE REGULATOR receiver
Y11_14581	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Y11_14591	COG0840	transmembrane signaling receptor activity
Y11_14601	COG0840	transmembrane signaling receptor activity
Y11_14621	COG0835	chemotaxis
Y11_14641	COG0643	Histidine kinase
Y11_14641	COG2198	Histidine kinase
Y11_14651	COG1360	Flagellar Motor Protein
Y11_14701	COG0589	response to stress
Y11_14711	COG2130	NADP-dependent
Y11_14731	COG1285	pathogenesis
Y11_14761	COG0840	transmembrane signaling receptor activity
Y11_14791	COG1278	Cold shock
Y11_14801	COG1609	Transcriptional regulator
Y11_14811	COG3250	beta-galactosidase activity
Y11_14821	COG3328	transposase activity
Y11_14831	COG0604	alcohol dehydrogenase
Y11_14831	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_14831	COG3321	synthase
Y11_14901	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Y11_14931	COG3121	Chaperone
Y11_14981	COG1070	Carbohydrate kinase
Y11_15001	COG3228	Belongs to the MtfA family
Y11_15011	COG0582	viral genome integration into host DNA
Y11_15021	COG0583	DNA-binding transcription factor activity
Y11_15061	COG4227	nucleotidyltransferase activity
Y11_15141	COG2205	protein histidine kinase activity
Y11_15141	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_15191	COG3121	Chaperone
Y11_15231	COG3122	Protein conserved in bacteria
Y11_15241	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_15241	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_15251	COG2814	Major facilitator Superfamily
Y11_15281	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Y11_15311	COG0471	metal ion transport
Y11_15331	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
Y11_15331	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Y11_15341	COG3051	citrate lyase alpha subunit
Y11_15351	COG2301	Belongs to the HpcH HpaI aldolase family
Y11_15361	COG3052	prosthetic group binding
Y11_15371	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
Y11_15381	COG3290	protein histidine kinase activity
Y11_15391	COG4565	transcriptional regulatory protein
Y11_15421	COG2271	Major facilitator Superfamily
Y11_15431	COG1840	ABC-type Fe3 transport system, periplasmic component
Y11_15451	COG3842	ATPase activity
Y11_15501	COG0784	Response regulator, receiver
Y11_15501	COG0835	chemotaxis
Y11_15521	COG1349	DNA-binding transcription factor activity
Y11_15531	COG0561	phosphatase activity
Y11_15541	COG0352	thiamine-phosphate diphosphorylase activity
Y11_15571	COG0534	Mate efflux family protein
Y11_15581	COG0137	argininosuccinate synthase activity
Y11_15631	COG3501	Rhs element vgr protein
Y11_15721	COG3188	usher protein
Y11_15731	COG3121	Chaperone
Y11_15881	COG2211	Major facilitator Superfamily
Y11_15901	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Y11_15941	COG1492	cobalamin metabolic process
Y11_16051	COG2875	Belongs to the precorrin methyltransferase family
Y11_16071	COG2241	protein methyltransferase activity
Y11_16081	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Y11_16101	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Y11_16151	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Y11_16221	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Y11_16281	COG1012	belongs to the aldehyde dehydrogenase family
Y11_16301	COG4656	Part of a membrane complex involved in electron transport
Y11_16321	COG4810	utilization protein
Y11_16341	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y11_16361	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y11_16381	COG1879	ABC-type sugar transport system periplasmic component
Y11_16401	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_16421	COG2926	Belongs to the UPF0265 family
Y11_16431	COG1289	transmembrane transporter activity
Y11_16441	COG3320	Male sterility
Y11_16441	COG1022	Amp-dependent synthetase and ligase
Y11_16451	COG2925	Exonuclease
Y11_16461	COG0531	amino acid
Y11_16471	COG0371	Dehydrogenase
Y11_16481	COG1129	ABC transporter
Y11_16491	COG1129	ABC transporter
Y11_16501	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_16511	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_16521	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Y11_16541	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y11_16551	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Y11_16551	COG0131	Imidazoleglycerol-phosphate dehydratase
Y11_16561	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Y11_16571	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Y11_16581	COG0107	imidazoleglycerol-phosphate synthase activity
Y11_16591	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Y11_16591	COG0140	phosphoribosyl-ATP diphosphatase activity
Y11_16601	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Y11_16621	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y11_16631	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Y11_16721	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_16811	COG1253	flavin adenine dinucleotide binding
Y11_16821	COG3069	C4-dicarboxylate transmembrane transporter activity
Y11_16831	COG2982	Protein involved in outer membrane biogenesis
Y11_16851	COG0572	uridine kinase
Y11_16861	COG0489	protein tyrosine kinase activity
Y11_16881	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y11_16881	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y11_16921	COG2814	Major facilitator Superfamily
Y11_16931	COG1380	Effector of murein hydrolase LrgA
Y11_16941	COG1346	cytolysis
Y11_16961	COG0281	malic enzyme
Y11_16971	COG2949	membrane
Y11_16981	COG0298	carbon dioxide binding
Y11_16991	COG0375	protein maturation
Y11_17001	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y11_17011	COG0651	ATP synthesis coupled electron transport
Y11_17021	COG0650	Formate hydrogenlyase subunit 4
Y11_17031	COG0650	Formate hydrogenlyase subunit 4
Y11_17041	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y11_17051	COG4237	Hydrogenase 4 membrane
Y11_17061	COG0651	ATP synthesis coupled electron transport
Y11_17071	COG3261	NADH dehydrogenase
Y11_17071	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Y11_17081	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y11_17091	COG3260	NADH ubiquinone oxidoreductase 20
Y11_17111	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Y11_17121	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y11_17131	COG3383	formate dehydrogenase (NAD+) activity
Y11_17141	COG3604	Transcriptional regulator
Y11_17201	COG2311	Membrane
Y11_17211	COG0302	gtp cyclohydrolase
Y11_17221	COG0477	Major facilitator Superfamily
Y11_17231	COG0583	DNA-binding transcription factor activity
Y11_17291	COG0577	efflux transmembrane transporter activity
Y11_17291	COG1136	(ABC) transporter
Y11_17321	COG0303	'Molybdopterin
Y11_17331	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y11_17351	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_17361	COG0488	(ABC) transporter
Y11_17401	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Y11_17431	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Y11_17461	COG4106	trans-aconitate 2-methyltransferase activity
Y11_17471	COG0783	Belongs to the Dps family
Y11_17481	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Y11_17501	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_17511	COG0765	amino acid transport
Y11_17521	COG1126	abc transporter atp-binding protein
Y11_17551	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Y11_17611	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Y11_17621	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Y11_17671	COG0697	spore germination
Y11_17691	COG0583	DNA-binding transcription factor activity
Y11_17701	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_17721	COG1174	glycine betaine transport
Y11_17731	COG1125	glycine betaine transport
Y11_17741	COG1174	glycine betaine transport
Y11_17751	COG1732	Glycine betaine
Y11_17781	COG2897	thiosulfate sulfurtransferase activity
Y11_17791	COG0410	ABC transporter
Y11_17801	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Y11_17821	COG0559	Belongs to the binding-protein-dependent transport system permease family
Y11_17841	COG4807	Protein conserved in bacteria
Y11_17871	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Y11_17891	COG2261	transglycosylase associated protein
Y11_17911	COG1403	HNH endonuclease
Y11_17931	COG0277	FAD linked oxidase domain protein
Y11_17941	COG1686	Belongs to the peptidase S11 family
Y11_17961	COG2239	Acts as a magnesium transporter
Y11_17981	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y11_17991	COG0513	Belongs to the DEAD box helicase family
Y11_18001	COG1309	transcriptional regulator
Y11_18011	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_18021	COG1131	(ABC) transporter
Y11_18031	COG0842	Transport permease protein
Y11_18041	COG0842	Transport permease protein
Y11_18051	COG0670	Belongs to the BI1 family
Y11_18061	COG0314	molybdopterin synthase activity
Y11_18071	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Y11_18081	COG0315	cyclic pyranopterin monophosphate synthase activity
Y11_18091	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Y11_18101	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Y11_18111	COG4628	conserved protein (DUF2132)
Y11_18121	COG0556	nucleotide-excision repair
Y11_18151	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Y11_18161	COG2226	methyltransferase
Y11_18171	COG0156	8-amino-7-oxononanoate synthase activity
Y11_18181	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Y11_18201	COG2706	6-phosphogluconolactonase activity
Y11_18211	COG0561	phosphatase activity
Y11_18231	COG4149	molybdate abc transporter
Y11_18241	COG0725	ABC transporter, periplasmic molybdate-binding protein
Y11_18251	COG0725	ABC transporter, periplasmic molybdate-binding protein
Y11_18271	COG3585	molybdate ion transport
Y11_18271	COG2005	Transcriptional regulator
Y11_18291	COG1119	ATPase activity
Y11_18311	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Y11_18321	COG1085	galactose-1-phosphate uridylyltransferase
Y11_18331	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Y11_18341	COG2017	converts alpha-aldose to the beta-anomer
Y11_18401	COG0588	phosphoglycerate mutase activity
Y11_18411	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Y11_18421	COG1230	cation diffusion facilitator family transporter
Y11_18441	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Y11_18451	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Y11_18461	COG2885	chlorophyll binding
Y11_18471	COG0823	Involved in the tonB-independent uptake of proteins
Y11_18481	COG3064	Membrane
Y11_18481	COG3064	Membrane
Y11_18491	COG0848	biopolymer transport protein
Y11_18501	COG0811	peptide transport
Y11_18511	COG0824	Thioesterase
Y11_18521	COG3790	cyd operon protein YbgE
Y11_18531	COG4890	Cyd operon protein YbgT
Y11_18541	COG1294	oxidase, subunit
Y11_18551	COG1271	oxidase subunit
Y11_18561	COG0737	Belongs to the 5'-nucleotidase family
Y11_18571	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Y11_18581	COG0045	succinate-CoA ligase (ADP-forming) activity
Y11_18591	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y11_18601	COG0567	Dehydrogenase, E1 component
Y11_18621	COG1053	succinate dehydrogenase
Y11_18631	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Y11_18641	COG2009	succinate dehydrogenase
Y11_18661	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Y11_18691	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Y11_18701	COG1984	allophanate hydrolase subunit 2
Y11_18711	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Y11_18721	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Y11_18731	COG5212	phosphodiesterase
Y11_18751	COG3272	Protein of unknown function (DUF1722)
Y11_18761	COG1073	alpha beta
Y11_18761	COG3064	Membrane
Y11_18761	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Y11_18761	COG1073	alpha beta
Y11_18761	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Y11_18761	COG3064	Membrane
Y11_18771	COG2994	toxin metabolic process
Y11_18801	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Y11_18811	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Y11_18821	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Y11_18831	COG2205	protein histidine kinase activity
Y11_18841	COG0745	RESPONSE REGULATOR receiver
Y11_18871	COG0033	Phosphoglucomutase
Y11_18881	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Y11_18891	COG0596	Alpha beta hydrolase
Y11_18911	COG0840	transmembrane signaling receptor activity
Y11_18931	COG0735	belongs to the Fur family
Y11_18971	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y11_18981	COG1263	PTS System
Y11_18981	COG2190	(PTS) system
Y11_18981	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_18991	COG0363	glucosamine-6-phosphate deaminase activity
Y11_19001	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Y11_19011	COG1846	Transcriptional regulator
Y11_19011	COG1940	carbohydrate kinase activity
Y11_19031	COG0647	UMP catabolic process
Y11_19041	COG0367	asparagine synthase
Y11_19051	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y11_19061	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y11_19071	COG1702	phosphate starvation-inducible protein PhoH
Y11_19081	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Y11_19091	COG4535	Mg2 and Co2 transporter CorC
Y11_19101	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Y11_19131	COG0765	amino acid transport
Y11_19141	COG0765	amino acid transport
Y11_19151	COG1126	abc transporter atp-binding protein
Y11_19161	COG2888	peptidyl-tyrosine sulfation
Y11_19181	COG0495	leucyl-tRNA aminoacylation
Y11_19191	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Y11_19201	COG1466	dna polymerase III delta subunit
Y11_19211	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Y11_19221	COG0799	negative regulation of ribosome biogenesis
Y11_19241	COG0768	penicillin binding
Y11_19251	COG0772	Belongs to the SEDS family
Y11_19261	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Y11_19271	COG1686	Belongs to the peptidase S11 family
Y11_19281	COG2921	Belongs to the UPF0250 family
Y11_19291	COG0321	lipoyl(octanoyl) transferase activity
Y11_19301	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Y11_19311	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y11_19321	COG3706	GGDEF domain
Y11_19331	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Y11_19341	COG1278	Cold shock
Y11_19351	COG1278	Cold shock
Y11_19361	COG2197	response regulator
Y11_19381	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y11_19411	COG5265	(ABC) transporter
Y11_19441	COG2986	histidine ammonia-lyase
Y11_19451	COG2850	peptidyl-arginine hydroxylation
Y11_19481	COG0582	viral genome integration into host DNA
Y11_19641	COG0582	viral genome integration into host DNA
Y11_19651	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Y11_19661	COG2501	S4 domain
Y11_19671	COG0215	cysteine-tRNA ligase activity
Y11_19681	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Y11_19691	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_19701	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Y11_19711	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Y11_19721	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Y11_19731	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Y11_19741	COG4181	ATPase activity
Y11_19751	COG2755	lipolytic protein G-D-S-L family
Y11_19761	COG0300	oxidoreductase activity
Y11_19771	COG3118	belongs to the thioredoxin family
Y11_19781	COG0330	HflC and HflK could
Y11_19791	COG1585	Membrane protein implicated in regulation of membrane protease activity
Y11_19801	COG0789	Transcriptional regulator
Y11_19811	COG2217	Heavy metal translocating P-type atpase
Y11_19821	COG3735	TraB family
Y11_19831	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Y11_19841	COG0737	Belongs to the 5'-nucleotidase family
Y11_19861	COG2223	nitrite transmembrane transporter activity
Y11_19891	COG4651	solute:proton antiporter activity
Y11_19891	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y11_19901	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_19941	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y11_19951	COG0438	transferase activity, transferring glycosyl groups
Y11_19961	COG0438	transferase activity, transferring glycosyl groups
Y11_19971	COG1215	transferase activity, transferring glycosyl groups
Y11_19981	COG1216	Glycosyl transferase, family 2
Y11_19981	COG1442	glycosyl transferase family 8
Y11_19991	COG2244	polysaccharide biosynthetic process
Y11_20001	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Y11_20011	COG0563	adenylate kinase activity
Y11_20031	COG0326	Molecular chaperone. Has ATPase activity
Y11_20041	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Y11_20051	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Y11_20071	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Y11_20111	COG1196	nuclear chromosome segregation
Y11_20111	COG3264	Mechanosensitive ion channel
Y11_20121	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Y11_20131	COG1309	transcriptional regulator
Y11_20141	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_20151	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_20211	COG3457	Alanine racemase
Y11_20221	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Y11_20251	COG0254	rRNA binding
Y11_20261	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Y11_20271	COG0803	Belongs to the bacterial solute-binding protein 9 family
Y11_20281	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y11_20351	COG3695	enzyme binding
Y11_20361	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Y11_20371	COG1946	Acyl-CoA thioesterase
Y11_20381	COG0004	ammonium transporteR
Y11_20391	COG0347	Belongs to the P(II) protein family
Y11_20401	COG1132	(ABC) transporter
Y11_20411	COG1132	(ABC) transporter
Y11_20421	COG1522	sequence-specific DNA binding
Y11_20441	COG0561	phosphatase activity
Y11_20451	COG4533	DNA binding
Y11_20461	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Y11_20471	COG0824	Thioesterase
Y11_20481	COG1555	photosystem II stabilization
Y11_20491	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y11_20511	COG0776	regulation of translation
Y11_20521	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y11_20541	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Y11_20551	COG0740	serine-type endopeptidase activity
Y11_20561	COG0544	peptidyl-prolyl cis-trans isomerase activity
Y11_20571	COG0271	Belongs to the BolA IbaG family
Y11_20581	COG3056	Lipoprotein
Y11_20591	COG2223	nitrite transmembrane transporter activity
Y11_20611	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Y11_20621	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Y11_20631	COG1845	cytochrome c oxidase, subunit III
Y11_20641	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Y11_20651	COG0109	protoheme IX farnesyltransferase activity
Y11_20661	COG2814	Major facilitator Superfamily
Y11_20671	COG1666	GTP binding
Y11_20681	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Y11_20691	COG0693	protein deglycase activity
Y11_20701	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Y11_20701	COG0301	tRNA thio-modification
Y11_20721	COG0142	geranyltranstransferase activity
Y11_20731	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Y11_20741	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_20751	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Y11_20761	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Y11_20771	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y11_20781	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Y11_20791	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y11_20791	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y11_20801	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Y11_20831	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_20841	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y11_20851	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y11_20861	COG1862	Preprotein translocase
Y11_20871	COG0343	queuine tRNA-ribosyltransferase activity
Y11_20911	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Y11_20931	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Y11_20941	COG0450	alkyl hydroperoxide reductase
Y11_20981	COG0366	Alpha amylase catalytic
Y11_21001	COG1114	Component of the transport system for branched-chain amino acids
Y11_21021	COG5002	protein histidine kinase activity
Y11_21031	COG0745	RESPONSE REGULATOR receiver
Y11_21041	COG0420	3'-5' exonuclease activity
Y11_21051	COG0419	ATPase involved in DNA repair
Y11_21061	COG1940	carbohydrate kinase activity
Y11_21071	COG2974	May be involved in recombination
Y11_21081	COG3123	guanosine phosphorylase activity
Y11_21101	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y11_21171	COG2226	methyltransferase
Y11_21211	COG3459	Glycosyltransferase 36 associated
Y11_21251	COG2188	Transcriptional regulator
Y11_21261	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Y11_21271	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Y11_21301	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Y11_21321	COG2195	Cleaves the N-terminal amino acid of tripeptides
Y11_21331	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Y11_21361	COG2964	Protein conserved in bacteria
Y11_21371	COG1181	Belongs to the D-alanine--D-alanine ligase family
Y11_21391	COG2991	Protein conserved in bacteria
Y11_21401	COG1477	protein flavinylation
Y11_21411	COG2871	sodium ion transport
Y11_21421	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_21431	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_21441	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_21451	COG1805	sodium ion transport
Y11_21461	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y11_21471	COG3034	peptidoglycan biosynthetic process
Y11_21481	COG0121	glutamine amidotransferase
Y11_21501	COG1960	acyl-CoA dehydrogenase activity
Y11_21511	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
Y11_21561	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Y11_21581	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Y11_21591	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Y11_21601	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Y11_21611	COG0235	Class ii aldolase
Y11_21621	COG0436	Aminotransferase
Y11_21651	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Y11_21671	COG0765	amino acid transport
Y11_21681	COG0765	amino acid transport
Y11_21761	COG2814	Major facilitator Superfamily
Y11_21771	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Y11_21791	COG1846	Transcriptional regulator
Y11_21801	COG1538	Outer membrane efflux protein
Y11_21811	COG1566	PFAM secretion protein HlyD family protein
Y11_21821	COG2814	Major facilitator Superfamily
Y11_21831	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_21841	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y11_21851	COG3118	belongs to the thioredoxin family
Y11_21871	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y11_21871	COG1042	CoA-binding domain protein
Y11_21871	COG0045	succinate-CoA ligase (ADP-forming) activity
Y11_21881	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y11_21891	COG5544	Lipoprotein
Y11_21901	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Y11_21911	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y11_21921	COG0564	pseudouridine synthase activity
Y11_21941	COG0542	response to heat
Y11_21981	COG1605	Chorismate mutase
Y11_21981	COG0077	Prephenate dehydratase
Y11_21991	COG0287	Prephenate dehydrogenase
Y11_21991	COG1605	Chorismate mutase
Y11_22001	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Y11_22011	COG3279	Response regulator of the LytR AlgR family
Y11_22021	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Y11_22031	COG3137	Salt-induced outer membrane protein
Y11_22041	COG0335	large ribosomal subunit rRNA binding
Y11_22051	COG0336	Belongs to the RNA methyltransferase TrmD family
Y11_22061	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Y11_22071	COG0228	four-way junction DNA binding
Y11_22081	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Y11_22091	COG4137	Cytochrome C assembly protein
Y11_22101	COG4536	flavin adenine dinucleotide binding
Y11_22111	COG1854	S-ribosylhomocysteine lyase activity
Y11_22121	COG2918	glutathione biosynthetic process
Y11_22131	COG1238	metal cluster binding
Y11_22141	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_22151	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Y11_22161	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y11_22171	COG2137	regulation of response to DNA damage stimulus
Y11_22181	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Y11_22231	COG3381	protein complex oligomerization
Y11_22241	COG3302	dmso reductase anchor subunit
Y11_22251	COG0437	4 iron, 4 sulfur cluster binding
Y11_22261	COG0243	molybdopterin cofactor binding
Y11_22271	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_22271	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_22291	COG0559	Belongs to the binding-protein-dependent transport system permease family
Y11_22301	COG4177	L-phenylalanine transmembrane transporter activity
Y11_22311	COG1137	ATPase activity
Y11_22321	COG0410	ABC transporter
Y11_22431	COG0640	Transcriptional regulator
Y11_22441	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Y11_22471	COG1858	cytochrome C peroxidase
Y11_22481	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Y11_22491	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_22501	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_22541	COG1538	Outer membrane efflux protein
Y11_22561	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_22611	COG3539	Fimbrial protein
Y11_22621	COG3539	Fimbrial protein
Y11_22641	COG3121	Chaperone
Y11_22651	COG3188	usher protein
Y11_22671	COG3539	Fimbrial protein
Y11_22731	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Y11_22741	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y11_22751	COG1388	LysM domain
Y11_22751	COG4942	peptidase
Y11_22761	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Y11_22771	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Y11_22781	COG0585	pseudouridine synthase activity
Y11_22791	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Y11_22811	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Y11_22831	COG0529	Catalyzes the synthesis of activated sulfate
Y11_22841	COG2895	sulfate adenylyltransferase (ATP) activity
Y11_22851	COG0175	sulfate reduction
Y11_22861	COG1648	precorrin-2 dehydrogenase activity
Y11_22861	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y11_22871	COG2234	aminopeptidase activity
Y11_22901	COG0175	sulfate reduction
Y11_22911	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y11_22921	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Y11_22931	COG0720	synthase
Y11_22971	COG0602	queuosine metabolic process
Y11_23031	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Y11_23041	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Y11_23051	COG0583	DNA-binding transcription factor activity
Y11_23071	COG1279	arginine transmembrane transporter activity
Y11_23131	COG0191	fructose-bisphosphate aldolase activity
Y11_23141	COG0126	phosphoglycerate kinase activity
Y11_23151	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Y11_23161	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Y11_23171	COG0501	Belongs to the peptidase M48B family
Y11_23201	COG1166	arginine decarboxylase activity
Y11_23221	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Y11_23251	COG0640	Transcriptional regulator
Y11_23261	COG3091	SprT-like family
Y11_23271	COG2356	endonuclease I
Y11_23281	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Y11_23291	COG0189	ligase activity
Y11_23301	COG1678	Uncharacterized ACR, COG1678
Y11_23311	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Y11_23321	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y11_23341	COG2805	Type II/IV secretion system protein
Y11_23351	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Y11_23361	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Y11_23371	COG0762	integral membrane protein
Y11_23381	COG1872	DUF167
Y11_23391	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Y11_23401	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y11_23421	COG2066	Belongs to the glutaminase family
Y11_23431	COG3171	Protein conserved in bacteria
Y11_23441	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Y11_23451	COG1194	a g-specific adenine glycosylase
Y11_23461	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Y11_23471	COG0741	lytic transglycosylase activity
Y11_23491	COG1982	Orn Lys Arg decarboxylase major
Y11_23521	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Y11_23601	COG0531	amino acid
Y11_23611	COG1982	Orn Lys Arg decarboxylase major
Y11_23631	COG1289	transmembrane transporter activity
Y11_23681	COG0024	Methionine aminopeptidase
Y11_23691	COG4604	ABC transporter, ATP-binding protein
Y11_23701	COG4605	iron ion homeostasis
Y11_23731	COG4607	ABC-type enterochelin transport system periplasmic component
Y11_23761	COG0697	spore germination
Y11_23771	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_23801	COG0477	Major facilitator Superfamily
Y11_23811	COG1609	Transcriptional regulator
Y11_23831	COG1283	sodium-dependent phosphate transmembrane transporter activity
Y11_23861	COG0477	Major facilitator Superfamily
Y11_23871	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_23901	COG5001	Diguanylate cyclase
Y11_23921	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Y11_23941	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Y11_23951	COG0309	Hydrogenase expression formation protein (HypE)
Y11_23961	COG0409	Hydrogenase expression formation protein
Y11_23971	COG0298	carbon dioxide binding
Y11_23981	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y11_23991	COG0375	protein maturation
Y11_24001	COG1773	rubredoxin
Y11_24011	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Y11_24021	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Y11_24031	COG5557	Pfam Polysulphide reductase, NrfD
Y11_24041	COG0437	4 iron, 4 sulfur cluster binding
Y11_24051	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Y11_24061	COG3133	Outer membrane lipoprotein
Y11_24081	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Y11_24091	COG1191	sigma factor activity
Y11_24131	COG1516	flagellar protein fliS
Y11_24141	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Y11_24161	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Y11_24191	COG3710	Transcriptional regulator
Y11_24261	COG1706	bacterial-type flagellum-dependent cell motility
Y11_24271	COG1706	bacterial-type flagellum-dependent cell motility
Y11_24291	COG4786	Flagellar basal body rod
Y11_24311	COG1749	Flagellar hook protein flgE
Y11_24321	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y11_24331	COG1558	bacterial-type flagellum-dependent cell motility
Y11_24341	COG1815	bacterial-type flagellum-dependent cell motility
Y11_24381	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_24401	COG2801	Transposase and inactivated derivatives
Y11_24421	COG1136	(ABC) transporter
Y11_24421	COG0577	efflux transmembrane transporter activity
Y11_24521	COG2135	peptidase activity
Y11_24541	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_24601	COG4964	Belongs to the GSP D family
Y11_24711	COG0848	biopolymer transport protein
Y11_24721	COG0811	peptide transport
Y11_24731	COG0626	cystathionine gamma-synthase activity
Y11_24741	COG0586	Pfam SNARE associated Golgi protein
Y11_24751	COG2207	Transcriptional regulator
Y11_24761	COG1979	alcohol dehydrogenase
Y11_24771	COG0656	L-ascorbic acid biosynthetic process
Y11_24791	COG2132	Multicopper oxidase
Y11_24801	COG0204	Acyl-transferase
Y11_24811	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Y11_24821	COG2249	NAD(P)H dehydrogenase (quinone) activity
Y11_24831	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Y11_24851	COG0187	DNA topoisomerase II activity
Y11_24861	COG3150	esterase
Y11_24871	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Y11_24881	COG3151	Protein conserved in bacteria
Y11_24891	COG0494	nUDIX hydrolase
Y11_24901	COG1538	Outer membrane efflux protein
Y11_24921	COG5463	Belongs to the UPF0441 family
Y11_24931	COG0754	glutathionylspermidine amidase activity
Y11_24941	COG3384	dioxygenase
Y11_24951	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y11_24971	COG0531	amino acid
Y11_24981	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Y11_24981	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Y11_24991	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Y11_25001	COG3025	triphosphatase activity
Y11_25011	COG4991	sh3 domain protein
Y11_25021	COG0617	tRNA 3'-terminal CCA addition
Y11_25031	COG1968	undecaprenyl-diphosphatase activity
Y11_25041	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Y11_25051	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Y11_25061	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Y11_25091	COG0358	DNA primase activity
Y11_25101	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y11_25431	COG4695	Portal protein
Y11_25551	COG4974	Belongs to the 'phage' integrase family
Y11_25561	COG3876	Protein conserved in bacteria
Y11_25581	COG1472	Belongs to the glycosyl hydrolase 3 family
Y11_25611	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Y11_25621	COG1263	PTS System
Y11_25621	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_25641	COG0531	amino acid
Y11_25651	COG0076	glutamate decarboxylase activity
Y11_25661	COG0076	glutamate decarboxylase activity
Y11_25681	COG3247	response to pH
Y11_25701	COG1902	pentaerythritol trinitrate reductase activity
Y11_25701	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y11_25731	COG2813	Specifically methylates the guanine in position
Y11_25771	COG1451	nucleotide metabolic process
Y11_25781	COG0673	inositol 2-dehydrogenase activity
Y11_25791	COG0861	Integral membrane protein TerC family
Y11_25801	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Y11_25821	COG2721	sulfolactate sulfo-lyase activity
Y11_25831	COG0246	Mannitol dehydrogenase
Y11_25841	COG1904	glucuronate isomerase
Y11_25861	COG2271	Major facilitator Superfamily
Y11_25891	COG0586	Pfam SNARE associated Golgi protein
Y11_25921	COG4575	ribosome binding
Y11_25931	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
Y11_25951	COG2259	Doxx family
Y11_25971	COG0435	Glutathione S-transferase
Y11_25981	COG0583	DNA-binding transcription factor activity
Y11_25991	COG1741	Belongs to the pirin family
Y11_26001	COG1064	alcohol dehydrogenase
Y11_26011	COG1064	alcohol dehydrogenase
Y11_26021	COG1064	alcohol dehydrogenase
Y11_26031	COG0667	Aldo Keto reductase
Y11_26071	COG3121	Chaperone
Y11_26151	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Y11_26171	COG0792	nuclease activity
Y11_26181	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Y11_26191	COG2823	Periplasmic or secreted lipoprotein
Y11_26201	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_26211	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y11_26221	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Y11_26231	COG0784	Response regulator, receiver
Y11_26231	COG2198	Histidine kinase
Y11_26231	COG5002	protein histidine kinase activity
Y11_26241	COG1242	4 iron, 4 sulfur cluster binding
Y11_26251	COG0067	glutamate synthase
Y11_26251	COG0069	glutamate synthase activity
Y11_26251	COG0070	glutamate synthase
Y11_26261	COG0493	'glutamate synthase
Y11_26281	COG2969	positive regulation of protein catabolic process
Y11_26291	COG0625	glutathione transferase activity
Y11_26311	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y11_26321	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Y11_26331	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Y11_26341	COG3105	Protein conserved in bacteria
Y11_26351	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y11_26361	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y11_26371	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Y11_26381	COG5007	Belongs to the BolA IbaG family
Y11_26391	COG3113	response to antibiotic
Y11_26401	COG2854	intermembrane phospholipid transfer
Y11_26411	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Y11_26421	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Y11_26431	COG1127	ABC transporter
Y11_26441	COG0530	calcium, potassium:sodium antiporter activity
Y11_26451	COG0517	IMP dehydrogenase activity
Y11_26451	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Y11_26461	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Y11_26471	COG3117	lipopolysaccharide transmembrane transporter activity
Y11_26481	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Y11_26491	COG1137	ATPase activity
Y11_26501	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Y11_26521	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_26531	COG1660	Displays ATPase and GTPase activities
Y11_26541	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_26561	COG0540	Belongs to the ATCase OTCase family
Y11_26571	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Y11_26601	COG2308	Evidence 4 Homologs of previously reported genes of
Y11_26641	COG0366	Alpha amylase catalytic
Y11_26651	COG1263	PTS System
Y11_26651	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Y11_26671	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y11_26691	COG3093	addiction module antidote protein HigA
Y11_26701	COG3711	transcriptional antiterminator
Y11_26701	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_26711	COG2706	6-phosphogluconolactonase activity
Y11_26751	COG3964	amidohydrolase
Y11_26821	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y11_26831	COG3783	Cytochrome b(562)
Y11_26841	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_26851	COG0312	modulator of DNA gyrase
Y11_26861	COG3028	Belongs to the UPF0307 family
Y11_26871	COG2732	(Barnase) inhibitor
Y11_26901	COG1289	transmembrane transporter activity
Y11_26911	COG1566	PFAM secretion protein HlyD family protein
Y11_26931	COG0583	DNA-binding transcription factor activity
Y11_27071	COG0312	modulator of DNA gyrase
Y11_27081	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y11_27091	COG3164	Protein of unknown function
Y11_27101	COG1530	ribonuclease E activity
Y11_27121	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Y11_27131	COG1792	Involved in formation and maintenance of cell shape
Y11_27141	COG1077	Cell shape determining protein MreB Mrl
Y11_27151	COG2199	diguanylate cyclase activity
Y11_27151	COG2200	EAL domain
Y11_27161	COG0604	alcohol dehydrogenase
Y11_27181	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Y11_27191	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Y11_27201	COG0511	ligase activity, forming carbon-carbon bonds
Y11_27211	COG0439	Biotin carboxylase
Y11_27221	COG3924	membrane
Y11_27231	COG4145	pantothenate transmembrane transporter activity
Y11_27241	COG2264	protein methyltransferase activity
Y11_27251	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y11_27261	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Y11_27271	COG3706	GGDEF domain
Y11_27271	COG0745	RESPONSE REGULATOR receiver
Y11_27281	COG3133	Outer membrane lipoprotein
Y11_27291	COG1278	Cold shock
Y11_27301	COG1278	Cold shock
Y11_27331	COG0471	metal ion transport
Y11_27341	COG1560	Kdo2-lipid A biosynthetic process
Y11_27351	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_27371	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_27381	COG4597	amino acid ABC transporter
Y11_27391	COG0765	amino acid transport
Y11_27401	COG1126	abc transporter atp-binding protein
Y11_27421	COG1380	Effector of murein hydrolase LrgA
Y11_27431	COG0583	DNA-binding transcription factor activity
Y11_27441	COG0025	NhaP-type Na H and K H
Y11_27451	COG2252	PERMEase
Y11_27481	COG3550	peptidyl-serine autophosphorylation
Y11_27501	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Y11_27511	COG2315	Protein conserved in bacteria
Y11_27521	COG1448	Aminotransferase
Y11_27531	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y11_27541	COG0305	Participates in initiation and elongation during chromosome replication
Y11_27581	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Y11_27601	COG0735	belongs to the Fur family
Y11_27621	COG3237	CsbD-like
Y11_27631	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Y11_27641	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Y11_27651	COG2937	Belongs to the GPAT DAPAT family
Y11_27661	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Y11_27671	COG3161	chorismate lyase activity
Y11_27701	COG4580	involved in the transport of maltose and maltodextrins
Y11_27721	COG2182	Extracellular solute-binding protein
Y11_27731	COG1175	transmembrane transport
Y11_27741	COG3833	ABC-type maltose transport systems, permease component
Y11_27761	COG0166	Belongs to the GPI family
Y11_27771	COG0527	aspartate kinase activity
Y11_27821	COG1414	Transcriptional regulator
Y11_27831	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Y11_27841	COG2224	Isocitrate lyase
Y11_27851	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Y11_27861	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Y11_27891	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Y11_27911	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y11_27931	COG1309	transcriptional regulator
Y11_27941	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_27961	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Y11_27961	COG0678	peroxiredoxin activity
Y11_27971	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_28051	COG1629	transport
Y11_28061	COG0165	Argininosuccinate lyase
Y11_28081	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y11_28091	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Y11_28121	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Y11_28141	COG0527	aspartate kinase activity
Y11_28141	COG0460	homoserine dehydrogenase
Y11_28151	COG0626	cystathionine gamma-synthase activity
Y11_28161	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
Y11_28171	COG0254	rRNA binding
Y11_28181	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Y11_28191	COG1609	Transcriptional regulator
Y11_28201	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Y11_28211	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Y11_28221	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Y11_28231	COG1575	Belongs to the MenA family. Type 1 subfamily
Y11_28241	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Y11_28251	COG3074	FtsZ-dependent cytokinesis
Y11_28261	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Y11_28281	COG1494	fructose-1,6-bisphosphatase
Y11_28291	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_28301	COG2814	Major facilitator Superfamily
Y11_28341	COG3152	Membrane
Y11_28361	COG0149	triose-phosphate isomerase activity
Y11_28381	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Y11_28401	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Y11_28611	COG4695	Portal protein
Y11_28651	COG0653	protein targeting
Y11_28701	COG4974	Belongs to the 'phage' integrase family
Y11_28711	COG3678	ATP-independent chaperone mediated protein folding
Y11_28721	COG0745	RESPONSE REGULATOR receiver
Y11_28731	COG2205	protein histidine kinase activity
Y11_28741	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y11_28741	COG2169	Transcriptional regulator
Y11_28751	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Y11_28761	COG1045	serine acetyltransferase
Y11_28771	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Y11_28781	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Y11_28791	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Y11_28801	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Y11_28811	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Y11_28821	COG4942	peptidase
Y11_28831	COG2861	carbohydrate metabolic process
Y11_28871	COG1063	alcohol dehydrogenase
Y11_28881	COG0156	8-amino-7-oxononanoate synthase activity
Y11_28891	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y11_28901	COG0859	PFAM glycosyl transferase family 9
Y11_28911	COG0859	PFAM glycosyl transferase family 9
Y11_28921	COG1519	Transferase
Y11_28941	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Y11_28951	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Y11_28961	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Y11_28971	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Y11_28981	COG2003	Belongs to the UPF0758 family
Y11_28991	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Y11_29001	COG0756	dUTP diphosphatase activity
Y11_29011	COG1309	transcriptional regulator
Y11_29051	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Y11_29061	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Y11_29071	COG1561	YicC-like family, N-terminal region
Y11_29091	COG5001	Diguanylate cyclase
Y11_29101	COG1024	Enoyl-CoA hydratase
Y11_29111	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y11_29131	COG2860	membrane
Y11_29141	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y11_29161	COG1758	RNA polymerase activity
Y11_29171	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Y11_29181	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y11_29191	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Y11_29221	COG0786	glutamate:sodium symporter activity
Y11_29231	COG2233	PERMEase
Y11_29241	COG2982	Protein involved in outer membrane biogenesis
Y11_29281	COG3423	Transcriptional regulator
Y11_29291	COG0456	acetyltransferase
Y11_29301	COG1490	D-aminoacyl-tRNA deacylase activity
Y11_29311	COG1295	ribonuclease BN
Y11_29321	COG1011	Hydrolase
Y11_29341	COG0174	glutamine synthetase
Y11_29361	COG3852	Histidine kinase
Y11_29381	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y11_29391	COG3078	GTPase activator activity
Y11_29401	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Y11_29411	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y11_29411	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y11_29421	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Y11_29431	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Y11_29441	COG3084	Protein conserved in bacteria
Y11_29461	COG1763	Mo-molybdopterin cofactor biosynthetic process
Y11_29491	COG2186	Transcriptional regulator
Y11_29511	COG0477	Major facilitator Superfamily
Y11_29521	COG1609	Transcriptional regulator
Y11_29531	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_29541	COG1879	ABC-type sugar transport system periplasmic component
Y11_29551	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_29571	COG1869	D-ribose catabolic process
Y11_29581	COG3158	transport of potassium into the cell
Y11_29591	COG0714	Associated with various cellular activities
Y11_29601	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Y11_29621	COG2502	aspartate--ammonia ligase
Y11_29631	COG1522	sequence-specific DNA binding
Y11_29641	COG0716	FMN binding
Y11_29661	COG0445	tRNA wobble uridine modification
Y11_29671	COG0357	Ribosomal RNA small subunit methyltransferase G
Y11_29681	COG3312	ion transport
Y11_29691	COG0356	it plays a direct role in the translocation of protons across the membrane
Y11_29711	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Y11_29721	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Y11_29731	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Y11_29741	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Y11_29751	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Y11_29761	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Y11_29771	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Y11_29781	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y11_29791	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Y11_29801	COG0573	inorganic phosphate transmembrane transporter activity
Y11_29811	COG0581	inorganic phosphate transmembrane transporter activity
Y11_29831	COG0704	Plays a role in the regulation of phosphate uptake
Y11_29861	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Y11_29871	COG0765	amino acid transport
Y11_29881	COG0765	amino acid transport
Y11_29891	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Y11_29901	COG2252	PERMEase
Y11_29921	COG4566	intracellular signal transduction
Y11_29941	COG0431	NADPH-dependent FMN reductase
Y11_29951	COG0840	transmembrane signaling receptor activity
Y11_29961	COG2011	ABC-type metal ion transport system permease component
Y11_29991	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Y11_30001	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Y11_30011	COG0706	membrane insertase activity
Y11_30021	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Y11_30031	COG0594	ribonuclease P activity
Y11_30051	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Y11_30071	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y11_30081	COG0592	DNA-directed DNA polymerase activity
Y11_30091	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Y11_30101	COG0187	DNA topoisomerase II activity
Y11_30111	COG0561	phosphatase activity
Y11_30121	COG2423	ornithine cyclodeaminase activity
Y11_30151	COG0823	Involved in the tonB-independent uptake of proteins
Y11_30161	COG5645	(Lipo)protein
Y11_30211	COG0569	domain protein
Y11_30211	COG2985	domain, Protein
Y11_30221	COG3977	Valine--pyruvate aminotransferase
Y11_30231	COG0366	Alpha amylase catalytic
Y11_30241	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y11_30301	COG0456	acetyltransferase
Y11_30311	COG2818	Glycosylase
Y11_30321	COG0752	glycyl-tRNA synthetase alpha subunit
Y11_30331	COG0751	glycine-tRNA ligase activity
Y11_30351	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_30351	COG2213	PTS system mannitol-specific
Y11_30361	COG0246	Mannitol dehydrogenase
Y11_30371	COG3722	fumarate hydratase activity
Y11_30391	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_30431	COG2258	MOSC domain
Y11_30441	COG0840	transmembrane signaling receptor activity
Y11_30461	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Y11_30481	COG0437	4 iron, 4 sulfur cluster binding
Y11_30491	COG2864	formate dehydrogenase
Y11_30501	COG3058	Necessary for formate dehydrogenase activity
Y11_30511	COG1921	L-seryl-tRNASec selenium transferase activity
Y11_30521	COG3276	selenocysteine insertion sequence binding
Y11_30541	COG3274	enterobacterial common antigen metabolic process
Y11_30571	COG3121	Chaperone
Y11_30581	COG1070	Carbohydrate kinase
Y11_30591	COG2115	Belongs to the xylose isomerase family
Y11_30601	COG2115	Belongs to the xylose isomerase family
Y11_30611	COG4213	ABC transporter substrate-binding protein
Y11_30631	COG4214	carbohydrate transport
Y11_30641	COG1609	Transcriptional regulator
Y11_30641	COG2207	Transcriptional regulator
Y11_30651	COG1609	Transcriptional regulator
Y11_30651	COG2207	Transcriptional regulator
Y11_30661	COG0582	viral genome integration into host DNA
Y11_30741	COG2986	histidine ammonia-lyase
Y11_30751	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Y11_30801	COG1482	cell wall glycoprotein biosynthetic process
Y11_30811	COG2723	6-phospho-beta-galactosidase activity
Y11_30851	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_30861	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_30871	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_30881	COG1447	Phosphotransferase system cellobiose-specific component IIA
Y11_30891	COG1940	carbohydrate kinase activity
Y11_30901	COG1609	Transcriptional regulator
Y11_30961	COG3328	transposase activity
Y11_30981	COG3210	domain, Protein
Y11_30991	COG2831	hemolysin activation secretion protein
Y11_31031	COG2271	Major facilitator Superfamily
Y11_31041	COG3851	Histidine kinase
Y11_31051	COG2197	response regulator
Y11_31061	COG2194	sulfuric ester hydrolase activity
Y11_31071	COG1764	response to oxidative stress
Y11_31081	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_31101	COG0747	negative chemotaxis
Y11_31111	COG0601	transmembrane transport
Y11_31121	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_31131	COG0444	Belongs to the ABC transporter superfamily
Y11_31141	COG4608	Belongs to the ABC transporter superfamily
Y11_31151	COG2194	sulfuric ester hydrolase activity
Y11_31191	COG1192	Involved in chromosome partitioning
Y11_31201	COG1215	transferase activity, transferring glycosyl groups
Y11_31211	COG1215	transferase activity, transferring glycosyl groups
Y11_31221	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Y11_31231	COG0457	Tetratricopeptide repeat
Y11_31231	COG3118	belongs to the thioredoxin family
Y11_31241	COG0457	Tetratricopeptide repeat
Y11_31241	COG3118	belongs to the thioredoxin family
Y11_31251	COG2200	EAL domain
Y11_31251	COG2199	diguanylate cyclase activity
Y11_31261	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y11_31291	COG1301	dicarboxylic acid transport
Y11_31301	COG0612	Peptidase, M16
Y11_31311	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_31321	COG1942	4-Oxalocrotonate Tautomerase
Y11_31341	COG2200	EAL domain
Y11_31351	COG2982	Protein involved in outer membrane biogenesis
Y11_31361	COG2134	cdp-diacylglycerol pyrophosphatase
Y11_31371	COG1295	ribonuclease BN
Y11_31391	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_31401	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Y11_31421	COG0742	ribosomal rna small subunit methyltransferase
Y11_31451	COG0589	response to stress
Y11_31471	COG0306	phosphate transporter
Y11_31481	COG2081	HI0933 family
Y11_31491	COG1301	dicarboxylic acid transport
Y11_31521	COG3799	methylaspartate ammonia-lyase activity
Y11_31531	COG4865	methylaspartate mutase activity
Y11_31551	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y11_31571	COG1648	precorrin-2 dehydrogenase activity
Y11_31571	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y11_31591	COG0583	DNA-binding transcription factor activity
Y11_31601	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_31601	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Y11_31621	COG0561	phosphatase activity
Y11_31641	COG0583	DNA-binding transcription factor activity
Y11_31651	COG2814	Major facilitator Superfamily
Y11_31671	COG3718	enzyme involved in inositol metabolism
Y11_31691	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y11_31711	COG0673	inositol 2-dehydrogenase activity
Y11_31721	COG1082	Xylose isomerase domain protein TIM barrel
Y11_31731	COG1247	-acetyltransferase
Y11_31741	COG1741	Belongs to the pirin family
Y11_31751	COG1609	Transcriptional regulator
Y11_31761	COG2610	gluconate transmembrane transporter activity
Y11_31771	COG3265	gluconokinase activity
Y11_31781	COG2095	MarC family integral membrane protein
Y11_31791	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y11_31831	COG3275	phosphorelay sensor kinase activity
Y11_31841	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Y11_31851	COG1523	belongs to the glycosyl hydrolase 13 family
Y11_31871	COG0297	glycogen (starch) synthase activity
Y11_31881	COG0058	SHG alpha-glucan phosphorylase activity
Y11_31891	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Y11_31911	COG1349	DNA-binding transcription factor activity
Y11_31921	COG0705	Rhomboid family
Y11_31951	COG2909	trisaccharide binding
Y11_31961	COG0058	SHG alpha-glucan phosphorylase activity
Y11_31971	COG1640	4-alpha-glucanotransferase
Y11_31981	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_31991	COG0316	Belongs to the HesB IscA family
Y11_31991	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Y11_32001	COG1040	competence protein
Y11_32021	COG0596	Alpha beta hydrolase
Y11_32051	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Y11_32071	COG1918	ferrous iron import across plasma membrane
Y11_32081	COG2183	response to ionizing radiation
Y11_32141	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y11_32151	COG0745	RESPONSE REGULATOR receiver
Y11_32191	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Y11_32211	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Y11_32221	COG1011	Hydrolase
Y11_32261	COG0494	nUDIX hydrolase
Y11_32271	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Y11_32321	COG4796	Type ii and iii secretion system protein
Y11_32331	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y11_32371	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Y11_32391	COG0180	Tryptophanyl-tRNA synthetase
Y11_32401	COG1648	precorrin-2 dehydrogenase activity
Y11_32401	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Y11_32421	COG2146	nitrite reductase [NAD(P)H] activity
Y11_32431	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Y11_32451	COG0402	S-adenosylhomocysteine deaminase activity
Y11_32461	COG0738	Major facilitator superfamily
Y11_32481	COG1486	melibiose metabolic process
Y11_32501	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Y11_32511	COG0433	COG0433 Predicted ATPase
Y11_32551	COG1289	transmembrane transporter activity
Y11_32571	COG1765	OsmC-like protein
Y11_32581	COG3954	Phosphoribulokinase
Y11_32591	COG3089	Belongs to the UPF0270 family
Y11_32601	COG0429	hydrolase of the alpha beta-hydrolase fold
Y11_32641	COG4521	taurine ABC transporter
Y11_32661	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Y11_32671	COG2175	clavaminate synthase activity
Y11_32691	COG1216	Glycosyl transferase, family 2
Y11_32701	COG0488	(ABC) transporter
Y11_32711	COG2249	NAD(P)H dehydrogenase (quinone) activity
Y11_32731	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
Y11_32741	COG1047	Peptidyl-prolyl cis-trans
Y11_32751	COG2900	Belongs to the SlyX family
Y11_32761	COG0545	Peptidyl-prolyl cis-trans isomerase
Y11_32771	COG2964	Protein conserved in bacteria
Y11_32781	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Y11_32791	COG2923	Belongs to the DsrF TusC family
Y11_32801	COG2168	tRNA wobble position uridine thiolation
Y11_32811	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Y11_32821	COG0049	tRNA binding
Y11_32841	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y11_32871	COG0051	transcription antitermination factor activity, RNA binding
Y11_32881	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Y11_32891	COG0088	Forms part of the polypeptide exit tunnel
Y11_32901	COG0089	rRNA binding
Y11_32911	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Y11_32921	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Y11_32931	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Y11_32941	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Y11_32951	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Y11_32961	COG0255	Belongs to the universal ribosomal protein uL29 family
Y11_32971	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Y11_32981	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Y11_32991	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Y11_33001	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Y11_33021	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Y11_33031	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Y11_33041	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Y11_33051	COG1841	ribosomal large subunit assembly
Y11_33061	COG0200	Binds to the 23S rRNA
Y11_33071	COG0201	protein transport
Y11_33081	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Y11_33091	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Y11_33101	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Y11_33111	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Y11_33121	COG0202	RNA polymerase activity
Y11_33131	COG0203	ribosomal protein L17
Y11_33151	COG0789	Transcriptional regulator
Y11_33161	COG3036	rescue of stalled ribosome
Y11_33191	COG1970	mechanosensitive ion channel activity
Y11_33201	COG0569	domain protein
Y11_33211	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y11_33211	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y11_33221	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y11_33231	COG0242	peptide deformylase activity
Y11_33241	COG0758	DNA mediated transformation
Y11_33261	COG0551	DNA topoisomerase type I activity
Y11_33271	COG0009	L-threonylcarbamoyladenylate synthase
Y11_33281	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Y11_33291	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Y11_33331	COG1879	ABC-type sugar transport system periplasmic component
Y11_33341	COG1129	ABC transporter
Y11_33351	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_33361	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_33371	COG0583	DNA-binding transcription factor activity
Y11_33381	COG3085	chromosome segregation
Y11_33421	COG3978	acetolactate synthase activity
Y11_33431	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y11_33451	COG0129	dihydroxy-acid dehydratase activity
Y11_33491	COG0583	DNA-binding transcription factor activity
Y11_33501	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Y11_33551	COG3121	Chaperone
Y11_33581	COG3121	Chaperone
Y11_33601	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y11_33631	COG0248	Ppx GppA phosphatase
Y11_33651	COG3118	belongs to the thioredoxin family
Y11_33661	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Y11_33671	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y11_33681	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
Y11_33691	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Y11_33701	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Y11_33711	COG1088	dTDP-glucose 4,6-dehydratase activity
Y11_33721	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Y11_33731	COG0456	acetyltransferase
Y11_33741	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Y11_33751	COG2244	polysaccharide biosynthetic process
Y11_33761	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Y11_33791	COG1113	amino acid transport
Y11_33801	COG1113	amino acid transport
Y11_33831	COG3071	HemY protein
Y11_33841	COG2959	enzyme of heme biosynthesis
Y11_33851	COG1587	Uroporphyrinogen-III synthase
Y11_33861	COG0181	hydroxymethylbilane synthase activity
Y11_33881	COG3072	Adenylate cyclase
Y11_33891	COG1965	Belongs to the frataxin family
Y11_33901	COG5567	small periplasmic lipoprotein
Y11_33911	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Y11_33921	COG3159	Protein conserved in bacteria
Y11_33931	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Y11_33941	COG1011	Hydrolase
Y11_33951	COG0210	DNA helicase
Y11_33971	COG5441	Belongs to the UPF0261 family
Y11_33981	COG5564	TIM-barrel signal transduction protein
Y11_33991	COG0598	Magnesium transport protein CorA
Y11_34011	COG2050	protein possibly involved in aromatic compounds catabolism
Y11_34021	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Y11_34031	COG0514	ATP-dependent DNA helicase (RecQ)
Y11_34041	COG1280	lysine exporter protein (LysE YggA)
Y11_34051	COG1280	lysine exporter protein (LysE YggA)
Y11_34061	COG2267	carboxylic ester hydrolase activity
Y11_34071	COG0561	phosphatase activity
Y11_34081	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_34091	COG0584	glycerophosphoryl diester phosphodiesterase
Y11_34101	COG2271	Major facilitator Superfamily
Y11_34121	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Y11_34131	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
Y11_34141	COG0247	lactate metabolic process
Y11_34161	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Y11_34171	COG0425	Belongs to the sulfur carrier protein TusA family
Y11_34181	COG2217	Heavy metal translocating P-type atpase
Y11_34191	COG3714	YhhN family
Y11_34221	COG3776	membrane
Y11_34231	COG0742	ribosomal rna small subunit methyltransferase
Y11_34251	COG0552	protein localization to endoplasmic reticulum
Y11_34261	COG2884	Cell division ATP-binding protein ftsE
Y11_34271	COG2177	Part of the ABC transporter FtsEX involved in
Y11_34321	COG0683	leucine binding
Y11_34331	COG0559	Belongs to the binding-protein-dependent transport system permease family
Y11_34341	COG4177	L-phenylalanine transmembrane transporter activity
Y11_34351	COG0411	ABC transporter
Y11_34361	COG0410	ABC transporter
Y11_34441	COG1653	transport
Y11_34451	COG1653	transport
Y11_34461	COG1175	transmembrane transport
Y11_34471	COG0395	ABC-type sugar transport system, permease component
Y11_34481	COG3842	ATPase activity
Y11_34491	COG0584	glycerophosphoryl diester phosphodiesterase
Y11_34501	COG0679	Auxin Efflux Carrier
Y11_34511	COG0583	DNA-binding transcription factor activity
Y11_34521	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Y11_34531	COG0412	Dienelactone hydrolase
Y11_34541	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Y11_34601	COG1966	Carbon starvation protein
Y11_34611	COG0586	Pfam SNARE associated Golgi protein
Y11_34621	COG1322	Protein conserved in bacteria
Y11_34631	COG2226	methyltransferase
Y11_34651	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Y11_34661	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y11_34671	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Y11_34681	COG0805	protein transport
Y11_34721	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Y11_34741	COG0183	Belongs to the thiolase family
Y11_34751	COG1250	3-hydroxyacyl-CoA dehydrogenase
Y11_34751	COG1024	Enoyl-CoA hydratase
Y11_34761	COG0006	proline dipeptidase activity
Y11_34771	COG1739	Uncharacterized protein family UPF0029
Y11_34781	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Y11_34831	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Y11_34831	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Y11_34841	COG1072	(Pantothenic acid kinase))
Y11_34871	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y11_34881	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Y11_34891	COG0250	Participates in transcription elongation, termination and antitermination
Y11_34901	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Y11_34911	COG0081	regulation of translation
Y11_34921	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Y11_34931	COG0222	ribosome binding
Y11_34941	COG0085	RNA polymerase activity
Y11_34951	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Y11_34961	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_34981	COG2022	thiamine diphosphate biosynthetic process
Y11_34991	COG2104	thiamine diphosphate biosynthetic process
Y11_35001	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Y11_35021	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Y11_35031	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Y11_35041	COG2816	NAD+ diphosphatase activity
Y11_35051	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Y11_35061	COG1515	deoxyribonuclease V activity
Y11_35071	COG3068	Protein conserved in bacteria
Y11_35101	COG0151	Belongs to the GarS family
Y11_35111	COG0138	bifunctional purine biosynthesis protein purh
Y11_35131	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Y11_35141	COG3162	membrane
Y11_35151	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Y11_35161	COG1301	dicarboxylic acid transport
Y11_35171	COG2197	response regulator
Y11_35181	COG0784	Response regulator, receiver
Y11_35181	COG5002	protein histidine kinase activity
Y11_35181	COG2205	protein histidine kinase activity
Y11_35501	COG2391	methyltransferase activity
Y11_35521	COG0425	Belongs to the sulfur carrier protein TusA family
Y11_35571	COG3712	iron ion homeostasis
Y11_35581	COG4771	TonB-dependent receptor
Y11_35591	COG4178	(ABC) transporter
Y11_35601	COG0612	Peptidase, M16
Y11_35611	COG2161	toxin-antitoxin pair type II binding
Y11_35621	COG4115	mRNA cleavage
Y11_35631	COG3264	Mechanosensitive ion channel
Y11_35631	COG1511	domain protein
Y11_35641	COG4774	siderophore transport
Y11_35661	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y11_35671	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Y11_35681	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y11_35691	COG4558	Periplasmic binding protein
Y11_35701	COG3720	iron ion transport
Y11_35741	COG3721	Heme iron utilization protein
Y11_35761	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Y11_35771	COG0814	amino acid
Y11_35781	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y11_35791	COG1882	Formate acetyltransferase
Y11_35801	COG1309	transcriptional regulator
Y11_35811	COG1929	Belongs to the glycerate kinase type-1 family
Y11_35821	COG1929	Belongs to the glycerate kinase type-1 family
Y11_35831	COG4232	protein-disulfide reductase activity
Y11_35851	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Y11_35881	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Y11_35891	COG0459	protein refolding
Y11_35921	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Y11_35941	COG2076	Multidrug Resistance protein
Y11_35961	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Y11_35971	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Y11_35981	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Y11_35991	COG1053	succinate dehydrogenase
Y11_36001	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Y11_36011	COG3264	Mechanosensitive ion channel
Y11_36011	COG1511	domain protein
Y11_36021	COG0688	phosphatidylethanolamine metabolic process
Y11_36031	COG1162	GTPase activity
Y11_36041	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Y11_36051	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Y11_36061	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Y11_36061	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Y11_36071	COG0802	atpase or kinase
Y11_36081	COG0860	N-Acetylmuramoyl-L-alanine amidase
Y11_36091	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Y11_36101	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Y11_36111	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Y11_36121	COG1923	regulation of RNA biosynthetic process
Y11_36131	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Y11_36141	COG0330	HflC and HflK could
Y11_36151	COG0330	HflC and HflK could
Y11_36161	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Y11_36171	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Y11_36181	COG1959	2 iron, 2 sulfur cluster binding
Y11_36191	COG0557	exoribonuclease II activity
Y11_36201	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y11_36221	COG1960	acyl-CoA dehydrogenase activity
Y11_36231	COG1960	acyl-CoA dehydrogenase activity
Y11_36241	COG3650	response to hydrogen peroxide
Y11_36251	COG1073	alpha beta
Y11_36271	COG0360	Binds together with S18 to 16S ribosomal RNA
Y11_36281	COG2965	DNA replication, synthesis of RNA primer
Y11_36291	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Y11_36301	COG0359	binds to the 23S rRNA
Y11_36321	COG3061	Opacity-associated protein A
Y11_36331	COG0545	Peptidyl-prolyl cis-trans isomerase
Y11_36351	COG0737	Belongs to the 5'-nucleotidase family
Y11_36361	COG1218	3'(2'),5'-bisphosphate nucleotidase
Y11_36371	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Y11_36391	COG1253	flavin adenine dinucleotide binding
Y11_36401	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Y11_36431	COG2911	Protein conserved in bacteria
Y11_36441	COG2105	PFAM AIG2 family protein
Y11_36451	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Y11_36481	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Y11_36491	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Y11_36511	COG1438	arginine binding
Y11_36521	COG0039	L-malate dehydrogenase activity
Y11_36541	COG0142	geranyltranstransferase activity
Y11_36551	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Y11_36561	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Y11_36571	COG0697	spore germination
Y11_36581	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y11_36591	COG0642	Histidine kinase
Y11_36601	COG0745	RESPONSE REGULATOR receiver
Y11_36611	COG2027	D-alanyl-D-alanine carboxypeptidase
Y11_36621	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y11_36631	COG1534	Rna-binding protein
Y11_36641	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Y11_36651	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y11_36661	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Y11_36671	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y11_36681	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Y11_36691	COG0779	Required for maturation of 30S ribosomal subunits
Y11_36701	COG0195	Participates in both transcription termination and antitermination
Y11_36711	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Y11_36721	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Y11_36731	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Y11_36741	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Y11_36751	COG1185	polyribonucleotide nucleotidyltransferase activity
Y11_36771	COG0513	Belongs to the DEAD box helicase family
Y11_36791	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Y11_36811	COG0814	amino acid
Y11_36821	COG3681	Belongs to the UPF0597 family
Y11_36861	COG3153	acetyltransferase
Y11_36871	COG2827	Endonuclease containing a URI domain
Y11_36881	COG0531	amino acid
Y11_36891	COG1982	Orn Lys Arg decarboxylase major
Y11_36931	COG1653	transport
Y11_36951	COG0395	ABC-type sugar transport system, permease component
Y11_36961	COG3842	ATPase activity
Y11_36981	COG3787	Belongs to the UPF0306 family
Y11_37011	COG0702	epimerase
Y11_37021	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Y11_37031	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Y11_37041	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Y11_37051	COG3454	Phosphonate metabolism
Y11_37061	COG4778	phosphonate C-P lyase system protein PhnL
Y11_37071	COG4107	phosphonate C-P lyase system protein PhnK
Y11_37081	COG3627	carbon phosphorus lyase activity
Y11_37091	COG3626	phosphonate metabolism
Y11_37101	COG3626	phosphonate metabolism
Y11_37111	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Y11_37121	COG3624	Phosphonate C-P lyase system protein PhnG
Y11_37131	COG2188	Transcriptional regulator
Y11_37201	COG4608	Belongs to the ABC transporter superfamily
Y11_37211	COG0444	Belongs to the ABC transporter superfamily
Y11_37231	COG0601	transmembrane transport
Y11_37261	COG2731	YhcH YjgK YiaL family protein
Y11_37281	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
Y11_37331	COG2927	DNA polymerase III (CHI subunit)
Y11_37341	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Y11_37351	COG0795	lipopolysaccharide-transporting ATPase activity
Y11_37361	COG0795	lipopolysaccharide-transporting ATPase activity
Y11_37451	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Y11_37451	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Y11_37461	COG0454	-acetyltransferase
Y11_37571	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Y11_37581	COG1830	Aldolase
Y11_37591	COG1879	ABC-type sugar transport system periplasmic component
Y11_37601	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_37611	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y11_37621	COG1129	ABC transporter
Y11_37631	COG2390	Transcriptional regulator
Y11_37641	COG1070	Carbohydrate kinase
Y11_37651	COG0859	PFAM glycosyl transferase family 9
Y11_37681	COG2235	arginine
Y11_37691	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_37701	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_37721	COG2376	Dihydroxyacetone kinase
Y11_37731	COG1461	Dihydroxyacetone kinase
Y11_37741	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
Y11_37741	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_37741	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y11_37761	COG2192	nodulation
Y11_37821	COG3284	Transcriptional regulator
Y11_37891	COG4772	TonB-dependent receptor
Y11_37901	COG3706	GGDEF domain
Y11_37941	COG0583	DNA-binding transcription factor activity
Y11_37951	COG0667	Aldo Keto reductase
Y11_37961	COG2813	Specifically methylates the guanine in position
Y11_37971	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
Y11_37981	COG0456	acetyltransferase
Y11_37991	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Y11_38001	COG2823	Periplasmic or secreted lipoprotein
Y11_38021	COG4667	esterase of the alpha-beta hydrolase superfamily
Y11_38031	COG0084	hydrolase, TatD family'
Y11_38041	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Y11_38051	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Y11_38061	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Y11_38071	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Y11_38081	COG0813	purine-nucleoside phosphorylase activity
Y11_38091	COG3726	membrane protein affecting hemolysin expression
Y11_38101	COG0560	Phosphoserine phosphatase
Y11_38141	COG0604	alcohol dehydrogenase
Y11_38171	COG0488	(ABC) transporter
Y11_38181	COG2885	chlorophyll binding
Y11_38191	COG2199	diguanylate cyclase activity
Y11_38211	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Y11_38221	COG0741	lytic transglycosylase activity
Y11_38231	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Y11_38241	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Y11_38251	COG0406	alpha-ribazole phosphatase activity
Y11_38261	COG3708	Transcriptional regulator
Y11_38261	COG2207	Transcriptional regulator
Y11_38271	COG3045	CreA protein
Y11_38281	COG0745	RESPONSE REGULATOR receiver
Y11_38321	COG0083	homoserine kinase activity
Y11_38341	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_38351	COG3022	response to hydroperoxide
Y11_38361	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y11_38371	COG0521	Mo-molybdopterin cofactor biosynthetic process
Y11_38401	COG1584	GPR1 FUN34 yaaH family protein
Y11_38411	COG0443	Heat shock 70 kDa protein
Y11_38421	COG0484	heat shock protein binding
Y11_38431	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Y11_38441	COG0583	DNA-binding transcription factor activity
Y11_38451	COG0268	Binds directly to 16S ribosomal RNA
Y11_38461	COG0196	riboflavin kinase activity
Y11_38471	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Y11_38481	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Y11_38491	COG1047	Peptidyl-prolyl cis-trans
Y11_38501	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Y11_38511	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Y11_38521	COG0505	Belongs to the CarA family
Y11_38531	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Y11_38541	COG1280	lysine exporter protein (LysE YggA)
Y11_38551	COG2966	Psort location CytoplasmicMembrane, score
Y11_38561	COG3610	response to peptide
Y11_38571	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Y11_38581	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y11_38591	COG2967	ApaG domain
Y11_38601	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Y11_38621	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Y11_38631	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Y11_38641	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Y11_38651	COG0564	pseudouridine synthase activity
Y11_38661	COG1470	cell adhesion involved in biofilm formation
Y11_38661	COG1388	LysM domain
Y11_38671	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Y11_38681	COG0417	DNA replication proofreading
Y11_38691	COG0586	Pfam SNARE associated Golgi protein
Y11_38711	COG1178	ABC-type Fe3 transport system permease component
Y11_38721	COG4143	(ABC) transporter
Y11_38751	COG4533	DNA binding
Y11_38761	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Y11_38791	COG2814	Major facilitator Superfamily
Y11_38801	COG0814	amino acid
Y11_38811	COG3033	Beta-eliminating lyase
Y11_38821	COG3033	Beta-eliminating lyase
Y11_38841	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Y11_38851	COG0473	3-isopropylmalate dehydrogenase activity
Y11_38861	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Y11_38891	COG1022	Amp-dependent synthetase and ligase
Y11_38911	COG0028	Belongs to the TPP enzyme family
Y11_38931	COG1609	Transcriptional regulator
Y11_38961	COG2001	Belongs to the MraZ family
Y11_38971	COG0275	rRNA processing
Y11_38981	COG3116	cell division
Y11_38991	COG0768	penicillin binding
Y11_39001	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Y11_39011	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Y11_39021	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y11_39041	COG0772	Belongs to the SEDS family
Y11_39051	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Y11_39061	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Y11_39081	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Y11_39091	COG0849	cell division
Y11_39101	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Y11_39141	COG0653	protein targeting
Y11_39151	COG0494	nUDIX hydrolase
Y11_39161	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Y11_39181	COG0237	dephospho-CoA kinase activity
Y11_39191	COG0516	GMP reductase activity
Y11_39201	COG1459	type II secretion system
Y11_39211	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Y11_39221	COG4969	Belongs to the N-Me-Phe pilin family
Y11_39251	COG3725	Membrane protein required for beta-lactamase induction
Y11_39261	COG1113	amino acid transport
Y11_39271	COG1113	amino acid transport
Y11_39291	COG2186	Transcriptional regulator
Y11_39301	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Y11_39311	COG0508	dehydrogenase complex catalyzes the overall conversion of
Y11_39321	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y11_39341	COG4977	sequence-specific DNA binding
Y11_39371	COG3112	Uncharacterised protein family (UPF0231)
Y11_39381	COG0697	spore germination
Y11_39411	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Y11_39421	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Y11_39441	COG2132	Multicopper oxidase
Y11_39461	COG0288	reversible hydration of carbon dioxide
Y11_39471	COG1131	(ABC) transporter
Y11_39481	COG0842	Transport permease protein
Y11_39501	COG0726	polysaccharide deacetylase
Y11_39511	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Y11_39521	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Y11_39531	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Y11_39541	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Y11_39571	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Y11_39581	COG1489	DNA binding
Y11_39591	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Y11_39601	COG1643	Atp-dependent helicase
Y11_39611	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y11_39621	COG1120	ATPase activity
Y11_39631	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Y11_39641	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y11_39651	COG2223	nitrite transmembrane transporter activity
Y11_39661	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Y11_39691	COG0316	Belongs to the HesB IscA family
Y11_39711	COG2860	membrane
Y11_39731	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Y11_39741	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Y11_39751	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y11_39771	COG3850	Histidine kinase
Y11_39771	COG4999	Histidine kinase
Y11_39771	COG3437	response regulator, receiver
Y11_39771	COG2205	protein histidine kinase activity
Y11_39781	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y11_39791	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Y11_39801	COG3956	TIGRFAM MazG family protein
Y11_39811	COG0504	CTP synthase activity
Y11_39821	COG0148	phosphopyruvate hydratase activity
Y11_39831	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Y11_39841	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Y11_39851	COG3079	Belongs to the UPF0149 family
Y11_39861	COG0006	proline dipeptidase activity
Y11_39871	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y11_39881	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Y11_39901	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y11_39911	COG0509	glycine decarboxylation via glycine cleavage system
Y11_39921	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y11_39921	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y11_39941	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_39961	COG1272	protein, Hemolysin III
Y11_39991	COG0354	folic acid binding
Y11_40001	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Y11_40021	COG0745	RESPONSE REGULATOR receiver
Y11_40031	COG2205	protein histidine kinase activity
Y11_40041	COG2205	protein histidine kinase activity
Y11_40051	COG4452	Inner membrane protein CreD
Y11_40061	COG0716	FMN binding
Y11_40071	COG4974	Belongs to the 'phage' integrase family
Y11_40081	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Y11_40091	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Y11_40101	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Y11_40111	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Y11_40161	COG2944	sequence-specific DNA binding
Y11_40171	COG3328	transposase activity
Y11_40211	COG4319	ketosteroid isomerase
Y11_40221	COG3706	GGDEF domain
Y11_40251	COG0484	heat shock protein binding
Y11_40271	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_40281	COG1733	regulation of RNA biosynthetic process
Y11_40291	COG0288	reversible hydration of carbon dioxide
Y11_40361	COG1459	type II secretion system
Y11_40371	COG2165	general secretion pathway protein
Y11_40451	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Y11_40501	COG0840	transmembrane signaling receptor activity
Y11_40541	COG2814	Major facilitator Superfamily
Y11_40551	COG0583	DNA-binding transcription factor activity
Y11_40561	COG0019	diaminopimelate decarboxylase activity
Y11_40571	COG1609	Transcriptional regulator
Y11_40591	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_40601	COG0204	Acyl-transferase
Y11_40601	COG0318	PFAM AMP-dependent synthetase and ligase
Y11_40611	COG0477	Major facilitator Superfamily
Y11_40621	COG0667	Aldo Keto reductase
Y11_40631	COG0861	Integral membrane protein TerC family
Y11_40641	COG3066	DNA modification
Y11_40661	COG1051	belongs to the nudix hydrolase family
Y11_40681	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Y11_40691	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Y11_40731	COG4967	type IV pilus modification protein PilV
Y11_40741	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Y11_40751	COG1025	Belongs to the peptidase M16 family
Y11_40761	COG1074	ATP-dependent DNA helicase activity
Y11_40771	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y11_40781	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_40791	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Y11_40791	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Y11_40801	COG0860	N-Acetylmuramoyl-L-alanine amidase
Y11_40811	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Y11_40821	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Y11_40831	COG2166	iron-sulfur cluster assembly
Y11_40841	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Y11_40861	COG0583	DNA-binding transcription factor activity
Y11_40871	COG2363	Small membrane protein
Y11_40881	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Y11_40891	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_40901	COG3328	transposase activity
Y11_40911	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y11_40921	COG1611	Belongs to the LOG family
Y11_40931	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Y11_40931	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Y11_40951	COG3098	single-species biofilm formation
Y11_40961	COG0564	pseudouridine synthase activity
Y11_40991	COG2171	N-acyltransferase activity
Y11_41001	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Y11_41011	COG0024	Methionine aminopeptidase
Y11_41021	COG0052	Belongs to the universal ribosomal protein uS2 family
Y11_41031	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Y11_41041	COG0528	UMP kinase activity
Y11_41051	COG0233	cytoplasmic translational termination
Y11_41061	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Y11_41071	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Y11_41081	COG0575	Belongs to the CDS family
Y11_41091	COG0750	zinc metalloprotease
Y11_41111	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Y11_41121	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_41131	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y11_41141	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_41151	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Y11_41161	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Y11_41181	COG0825	malonyl-CoA metabolic process
Y11_41201	COG0346	lactoylglutathione lyase activity
Y11_41211	COG0037	tRNA processing
Y11_41231	COG4568	rho-dependent transcription termination
Y11_41251	COG4681	YaeQ
Y11_41271	COG3015	lipoprotein NlpE involved in copper resistance
Y11_41281	COG0442	prolyl-tRNA aminoacylation
Y11_41301	COG1720	tRNA m6t6A37 methyltransferase activity
Y11_41321	COG1464	Belongs to the NlpA lipoprotein family
Y11_41331	COG2011	ABC-type metal ion transport system permease component
Y11_41351	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Y11_41361	COG3328	transposase activity
Y11_41381	COG0656	L-ascorbic acid biosynthetic process
Y11_41391	COG0583	DNA-binding transcription factor activity
Y11_41411	COG2814	Major facilitator Superfamily
Y11_41431	COG3021	interspecies interaction between organisms
Y11_41461	COG1388	LysM domain
Y11_41461	COG0741	lytic transglycosylase activity
Y11_41471	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Y11_41481	COG2226	methyltransferase
Y11_41491	COG0328	RNA-DNA hybrid ribonuclease activity
Y11_41501	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Y11_41511	COG2113	Glycine betaine
Y11_41521	COG4176	ABC-type proline glycine betaine transport system permease component
Y11_41541	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Y11_41561	COG1780	Probably involved in ribonucleotide reductase function
Y11_41591	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Y11_41611	COG4575	ribosome binding
Y11_41641	COG2207	Transcriptional regulator
Y11_41651	COG0477	Major facilitator Superfamily
Y11_41691	COG1278	Cold shock
Y11_41771	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y11_41791	COG1124	(ABC) transporter
Y11_41831	COG0832	Belongs to the urease beta subunit family
Y11_41841	COG0804	urea catabolic process
Y11_41851	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Y11_41861	COG0830	nickel cation binding
Y11_41871	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Y11_41881	COG0829	nickel cation binding
Y11_41891	COG4413	Urea transporter
Y11_41901	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Y11_41941	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Y11_41951	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Y11_41971	COG0667	Aldo Keto reductase
Y11_42001	COG2133	pyrroloquinoline quinone binding
Y11_42011	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_42021	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Y11_42031	COG2723	6-phospho-beta-galactosidase activity
Y11_42041	COG1447	Phosphotransferase system cellobiose-specific component IIA
Y11_42051	COG2169	Transcriptional regulator
Y11_42051	COG1917	Cupin 2, conserved barrel domain protein
Y11_42061	COG3394	polysaccharide catabolic process
Y11_42071	COG0659	secondary active sulfate transmembrane transporter activity
Y11_42081	COG3328	transposase activity
Y11_42091	COG0582	viral genome integration into host DNA
Y11_42101	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Y11_42111	COG2867	negative regulation of translational initiation
Y11_42131	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y11_42141	COG0497	DNA recombination
Y11_42151	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Y11_42171	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Y11_42181	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Y11_42191	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Y11_42241	COG3547	Transposase (IS116 IS110 IS902 family)
Y11_42261	COG0513	Belongs to the DEAD box helicase family
Y11_42271	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Y11_42281	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Y11_42291	COG1595	DNA-templated transcription, initiation
Y11_42301	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
Y11_42341	COG0481	GTPase activity
Y11_42351	COG0681	Belongs to the peptidase S26 family
Y11_42361	COG0571	ribonuclease III activity
Y11_42371	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Y11_42381	COG1381	Involved in DNA repair and RecF pathway recombination
Y11_42391	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Y11_42401	COG0736	holo-[acyl-carrier-protein] synthase activity
Y11_42411	COG2610	gluconate transmembrane transporter activity
Y11_42421	COG1737	Transcriptional regulator
Y11_42441	COG0560	Phosphoserine phosphatase
Y11_42461	COG0590	tRNA wobble adenosine to inosine editing
Y11_42471	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Y11_42511	COG2205	protein histidine kinase activity
Y11_42521	COG3170	Tfp pilus assembly protein FimV
Y11_42531	COG2204	response regulator
Y11_42541	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y11_42541	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Y11_42551	COG0347	Belongs to the P(II) protein family
Y11_42581	COG1735	metal-dependent hydrolase with the TIM-barrel fold
Y11_42591	COG3457	Alanine racemase
Y11_42611	COG2188	Transcriptional regulator
Y11_42621	COG1017	nitric oxide dioxygenase activity
Y11_42621	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Y11_42631	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Y11_42641	COG2814	Major facilitator Superfamily
Y11_42651	COG3711	transcriptional antiterminator
Y11_42661	COG3683	transport system, periplasmic component
Y11_42671	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Y11_42681	COG0483	inositol monophosphate 1-phosphatase activity
Y11_42691	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Y11_42701	COG1959	2 iron, 2 sulfur cluster binding
Y11_42721	COG0822	iron-sulfur transferase activity
Y11_42731	COG0316	Belongs to the HesB IscA family
Y11_42741	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Y11_42751	COG0443	Heat shock 70 kDa protein
Y11_42761	COG0633	Ferredoxin
Y11_42771	COG2975	iron-sulfur cluster assembly
Y11_42801	COG3468	outer membrane autotransporter barrel domain protein
Y11_42841	COG2373	Large extracellular alpha-helical protein
Y11_42851	COG4953	penicillin-binding protein 1C
Y11_42881	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Y11_42901	COG1426	Protein conserved in bacteria
Y11_42911	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Y11_42931	COG0124	histidyl-tRNA synthetase
Y11_42941	COG2976	Protein conserved in bacteria
Y11_42951	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Y11_42971	COG1160	GTP binding
Y11_43001	COG1645	bacterial-type flagellum-dependent swarming motility
Y11_43011	COG1570	exodeoxyribonuclease VII activity
Y11_43021	COG0517	IMP dehydrogenase activity
Y11_43021	COG0516	GMP reductase activity
Y11_43041	COG0519	Catalyzes the synthesis of GMP from XMP
Y11_43041	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y11_43141	COG0351	phosphomethylpyrimidine kinase
Y11_43181	COG1349	DNA-binding transcription factor activity
Y11_43191	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
Y11_43201	COG1028	Short-chain dehydrogenase reductase Sdr
Y11_43231	COG3730	PTS system glucitol sorbitol-specific
Y11_43241	COG1597	lipid kinase activity
Y11_43261	COG3422	double-strand break repair
Y11_43271	COG0745	RESPONSE REGULATOR receiver
Y11_43281	COG2205	protein histidine kinase activity
Y11_43291	COG0477	Major facilitator Superfamily
Y11_43311	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Y11_43331	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Y11_43341	COG0443	Heat shock 70 kDa protein
Y11_43351	COG5002	protein histidine kinase activity
Y11_43351	COG3447	MASE1 domain protein
Y11_43351	COG5001	Diguanylate cyclase
Y11_43371	COG0581	inorganic phosphate transmembrane transporter activity
Y11_43381	COG0573	inorganic phosphate transmembrane transporter activity
Y11_43391	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Y11_43401	COG0248	Ppx GppA phosphatase
Y11_43421	COG2239	Acts as a magnesium transporter
Y11_43431	COG3447	MASE1 domain protein
Y11_43431	COG5002	protein histidine kinase activity
Y11_43431	COG5001	Diguanylate cyclase
Y11_43441	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y11_43451	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Y11_43461	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Y11_43471	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Y11_43481	COG2233	PERMEase
Y11_p0131	COG2963	transposase activity
Y11_p0141	COG2963	transposase activity
Y11_p0291	COG0640	Transcriptional regulator
Y11_p0301	COG0431	NADPH-dependent FMN reductase
Y11_p0351	COG2963	transposase activity
Y11_p0361	COG2963	transposase activity
Y11_p0411	COG1192	Involved in chromosome partitioning
Y11_p0421	COG1475	DNA binding
Y11_p0451	COG3609	addiction module antidote protein, CC2985 family
Y11_p0501	COG2801	Transposase and inactivated derivatives
Y11_p0711	COG4792	protein secretion
Y11_p0721	COG4791	protein targeting
Y11_p0731	COG4794	Type iii secretion
Y11_p0741	COG4790	Type iii secretion
Y11_p0751	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y11_p0911	COG3328	transposase activity
Y11_p0931	COG4886	Leucine-rich repeat (LRR) protein
Y11_p0931	COG4886	Leucine-rich repeat (LRR) protein
Y11_p1001	COG2963	transposase activity
Y11_p1011	COG2963	transposase activity
Y11_p1051	COG2801	Transposase and inactivated derivatives